Beta vulgaris var. crassa is undoubtedly a very important plant that is not used enough in the world. In this study, it was aimed to determine the cytotoxic activities of the components (essential oils, fatty acids, total phenol and flavonoid) found in the leaf parts of Beta vulgaris var. crassa against PC-3, MCF-7 and HeLa cancer cell lines. In addition, the effectiveness of these ingredients against bacteria and fungi that can cause serious health problems in humans was tested. In experiments, three tumor cell lines were exposed to various plant extract concentrations (31.25, 62.5, 125, 250, 500 and 1000 µg/mL) for 72 h. It was found that plant extracts showed high (SI: 2.14 > 2) cytotoxicity to PC-3 cells, moderate (SI: 1.62 < 2) to HeLa cells, and low (SI: 0.93 < 2) cytotoxicity to MCF-7 cells. Also, different plant extract concentrations were found to cause an inhibition rate of 16.3–22.3% in Staphylococcus aureus, 16.8–23.5% in Streptococcus pyogenes and 12–16.2% in Cutibacterium acnes. Similarly, inhibition rates were determined between 9.5–20.7% for Candida albicans, 3.5–7.7% for Candida auris, and 5.5–15.1% for Candida glabrata. The results showed that the plant extract exhibited a concentration-dependent cytotoxic and antimicrobial effect against both cancer cell lines and microbial pathogens.

Graphical Abstract

中文翻译：

---

甜菜精油、脂肪酸和生物活性化合物的抗菌、抗氧化和细胞毒性作用。 crassa（饲料甜菜）

甜菜变种crassa无疑是一种非常重要的植物，但在世界上的利用还不够。在本研究中，目的是确定甜菜叶部分中发现的成分（精油、脂肪酸、总酚和类黄酮）的细胞毒活性。crassa针对 PC-3、MCF-7 和 HeLa 癌细胞系。此外，还测试了这些成分对抗可能导致人类严重健康问题的细菌和真菌的有效性。在实验中，将三种肿瘤细胞系暴露于不同植物提取物浓度（31.25、62.5、125、250、500 和 1000 µg/mL）中 72 小时。结果发现，植物提取物对 PC-3 细胞表现出高（SI：2.14 > 2）细胞毒性，对 HeLa 细胞表现出中度（SI：1.62 < 2）细胞毒性，对 MCF-7 细胞表现出低（SI：0.93 < 2）细胞毒性。此外，不同浓度的植物提取物对金黄色葡萄球菌、化脓性链球菌和痤疮皮肤杆菌的抑制率为 16.3-22.3% 、16.8-23.5%和 12-16.2% 。同样，白色念珠菌的抑制率为 9.5-20.7% ，耳念珠菌为 3.5-7.7% ，光滑念珠菌为 5.5-15.1% 。结果表明，植物提取物对癌细胞系和微生物病原体表现出浓度依赖性细胞毒性和抗菌作用。

图形概要