Folic acid (FA) is a water-soluble vitamin found in diverse natural sources and is crucial for preserving human health. The risk of health issues due to FA deficiency underscores the need for a straightforward and sensitive FA detection methodology. Carbon dots (CDs) have gained significant attention owing to their exceptional fluorescence performance, biocompatibility, and easy accessibility. Consequently, numerous research studies have concentrated on developing advanced CD fluorescent probes to enable swift and precise FA detection. Despite these efforts, there is still a requirement for a thorough overview of the efficient synthesis of CDs and their practical applications in FA detection to further promote the widespread use of CDs. This review paper focuses on the practical applications of CD sensors for FA detection. It begins with an in-depth introduction to FA and CDs. Following that, based on various synthetic approaches, the prepared CDs are classified into diverse detection methods, such as single sensing, visual detection, and electrochemical methods. Furthermore, persistent challenges and potential avenues are highlighted for future research to provide valuable insights into crafting effective CDs and detecting FA.

Graphical Abstract

中文翻译：

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基于荧光碳点传感器的叶酸检测最新进展：综述

叶酸 (FA) 是一种水溶性维生素，存在于多种天然来源中，对于维护人类健康至关重要。 FA 缺乏导致健康问题的风险凸显了对简单且灵敏的 FA 检测方法的需求。碳点（CD）因其卓越的荧光性能、生物相容性和易于获取而受到广泛关注。因此，大量研究集中在开发先进的 CD 荧光探针，以实现快速、精确的 FA 检测。尽管做出了这些努力，仍然需要对 CD 的有效合成及其在 FA 检测中的实际应用进行全面的概述，以进一步促进 CD 的广泛使用。本文重点介绍 CD 传感器在 FA 检测中的实际应用。首先深入介绍 FA 和 CD。随后，根据不同的合成方法，所制备的CD被分为不同的检测方法，例如单一传感、视觉检测和电化学方法。此外，还强调了未来研究中持续存在的挑战和潜在途径，为制作有效的 CD 和检测 FA 提供有价值的见解。

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