-
11C-CFT PET brain imaging in Parkinson’s disease using a total-body PET/CT scanner EJNMMI Phys. (IF 4.0) Pub Date : 2024-04-25 Xiaolin Sun, Xiaoyue Tan, Qing Zhang, Shanzhen He, Siyun Wang, Yongrong Zhou, Qi Huang, Lei Jiang
This study aimed to evaluate the feasibility of 11C-CFT PET brain imaging in Parkinson’s Disease using a total-body PET/CT scanner and explore the optimal scan duration to guide the clinical practice. Thirty-two patients with Parkinson’s disease (PD) performing 11C-CFT PET/CT brain imaging using a total-body PET/CT scanner were retrospectively enrolled. The PET data acquired over a period of 900 s
-
Quantification of biochemical PSA dynamics after radioligand therapy with [177Lu]Lu-PSMA-I&T using a population pharmacokinetic/pharmacodynamic model EJNMMI Phys. (IF 4.0) Pub Date : 2024-04-24 Hinke Siebinga, Berlinda J. de Wit-van der Veen, Daphne M. V. de Vries-Huizing, Wouter V. Vogel, Jeroen J. M. A. Hendrikx, Alwin D. R. Huitema
There is an unmet need for prediction of treatment outcome or patient selection for [177Lu]Lu-PSMA therapy in patients with metastatic castration-resistant prostate cancer (mCRPC). Quantification of the tumor exposure–response relationship is pivotal for further treatment optimization. Therefore, a population pharmacokinetic (PK) model was developed for [177Lu]Lu-PSMA-I&T using SPECT/CT data and, subsequently
-
Joint EURADOS-EANM initiative for an advanced computational framework for the assessment of external dose rates from nuclear medicine patients EJNMMI Phys. (IF 4.0) Pub Date : 2024-04-22 Lara Struelens, Christelle Huet, David Broggio, Jérémie Dabin, Laurent Desorgher, Augusto Giussani, Wei Bo Li, Dietmar Nosske, Yi-Kang Lee, Lidia Cunha, Maria J. R. Carapinha, Mario Medvedec, Peter Covens
In order to ensure adequate radiation protection of critical groups such as staff, caregivers and the general public coming into proximity of nuclear medicine (NM) patients, it is necessary to consider the impact of the radiation emitted by the patients during their stay at the hospital or after leaving the hospital. Current risk assessments are based on ambient dose rate measurements in a single position
-
Phantom and clinical evaluation of the Bayesian penalised likelihood reconstruction algorithm Q.Clear without PSF correction in amyloid PET images EJNMMI Phys. (IF 4.0) Pub Date : 2024-04-22 Kei Wagatsuma, Muneyuki Sakata, Kenta Miwa, Yumi Hamano, Hirofumi Kawakami, Yuto Kamitaka, Tensho Yamao, Noriaki Miyaji, Kenji Ishibashi, Tetsuro Tago, Jun Toyohara, Kenji Ishii
Bayesian penalised likelihood (BPL) reconstruction, which incorporates point-spread-function (PSF) correction, provides higher signal-to-noise ratios and more accurate quantitation than conventional ordered subset expectation maximization (OSEM) reconstruction. However, applying PSF correction to brain PET imaging is controversial due to Gibbs artefacts that manifest as unpredicted cortical uptake
-
Extended MRI-based PET motion correction for cardiac PET/MRI EJNMMI Phys. (IF 4.0) Pub Date : 2024-04-06 Mueez Aizaz, Jochem A. J. van der Pol, Alina Schneider, Camila Munoz, Robert J. Holtackers, Yvonne van Cauteren, Herman van Langen, Joan G. Meeder, Braim M. Rahel, Roel Wierts, René M. Botnar, Claudia Prieto, Rik P. M. Moonen, M. Eline Kooi
A 2D image navigator (iNAV) based 3D whole-heart sequence has been used to perform MRI and PET non-rigid respiratory motion correction for hybrid PET/MRI. However, only the PET data acquired during the acquisition of the 3D whole-heart MRI is corrected for respiratory motion. This study introduces and evaluates an MRI-based respiratory motion correction method of the complete PET data. Twelve oncology
-
Gamma camera imaging characteristics of 166Ho and 99mTc used in Selective Internal Radiation Therapy EJNMMI Phys. (IF 4.0) Pub Date : 2024-04-06 David Kästner, Anja Braune, Claudia Brogsitter, Robert Freudenberg, Jörg Kotzerke, Enrico Michler
The administration of a 166Ho scout dose is available as an alternative to 99mTc particles for pre-treatment imaging in Selective Internal Radiation Therapy (SIRT). It has been reported that the 166Ho scout dose may be more accurate for the prediction of microsphere distribution and the associated therapy planning. The aim of the current study is to compare the scintigraphic imaging characteristics
-
Bone marrow dosimetry in low volume mHSPC patients receiving Lu-177-PSMA therapy using SPECT/CT EJNMMI Phys. (IF 4.0) Pub Date : 2024-04-03 Dagmar Grob, Bastiaan M. Privé, Constantijn H. J. Muselaers, Niven Mehra, James Nagarajah, Mark W. Konijnenberg, Steffie M. B. Peters
Bone marrow toxicity in advanced prostate cancer patients who receive [177Lu]Lu-PSMA-617 is a well-known concern. In early stage patients; e.g. low volume metastatic hormone sensitive prostate cancer (mHSPC) patients, prevention of late bone marrow toxicity is even more crucial due to longer life expectancy. To date, bone marrow dosimetry is primarily performed using blood sampling. This method is
-
Impact of scatter correction on personalized dosimetry in selective internal radiotherapy using 166Ho-PLLA: a single-center study including Monte-Carlo simulation, phantom and patient imaging EJNMMI Phys. (IF 4.0) Pub Date : 2024-04-02 Benoît Collette, Marie Mannie-Corbisier, Ana-Maria Bucalau, Nicolas Pauly, Gontran Verset, Rodrigo Moreno-Reyes, Patrick Flamen, Nicola Trotta
Developments in transarterial radioembolization led to the conception of new microspheres loaded with holmium-166 (166Ho). However, due to the complexity of the scatter components in 166Ho single photon emission computed tomography (SPECT), questions about image quality and dosimetry are emerging. The aims of this work are to investigate the scatter components and correction methods to propose a suitable
-
Impact of different models based on blood samples and images for bone marrow dosimetry after 177Lu-labeled somatostatin-receptor therapy EJNMMI Phys. (IF 4.0) Pub Date : 2024-04-02 Delphine Vallot, Séverine Brillouet, Séléna Pondard, Lavinia Vija, Jean-Sébastien Texier, Lawrence Dierickx, Frédéric Courbon
Peptide receptor radionuclide therapy with 177Lu-DOTATATE is a recognized option for treating neuroendocrine tumors and has few toxicities, except for the kidneys and bone marrow. The bone marrow dose is generally derived from a SPECT/CT image-based method with four timepoints or from a blood-based method with up to 9 timepoints, but there is still no reference method. This retrospective single-center
-
Optimising total knee replacement imaging: a novel 3D printed PET/CT anthropomorphic phantom for metal artefact simulation EJNMMI Phys. (IF 4.0) Pub Date : 2024-03-28 Rajeh Assiri, Karen Knapp, Jon Fulford, Junning Chen
Arthroplasty phantoms, including total knee replacement (TKR) phantoms, have been frequently used to test metal artefact reduction methods applied to positron emission tomography/computed tomography (PET/CT) images. These phantoms generally simulate either simple anatomical features or simple activity distribution around the metal inserts in the PET/CT scans. 3D printing has been used recently to fabricate
-
Assessment of the axial resolution of a compact gamma camera with coded aperture collimator EJNMMI Phys. (IF 4.0) Pub Date : 2024-03-21 Tobias Meißner, Laura Antonia Cerbone, Paolo Russo, Werner Nahm, Jürgen Hesser
Handheld gamma cameras with coded aperture collimators are under investigation for intraoperative imaging in nuclear medicine. Coded apertures are a promising collimation technique for applications such as lymph node localization due to their high sensitivity and the possibility of 3D imaging. We evaluated the axial resolution and computational performance of two reconstruction methods. An experimental
-
Comparison of a 3D CZT and conventional SPECT/CT system for quantitative Lu-177 SPECT imaging EJNMMI Phys. (IF 4.0) Pub Date : 2024-03-19 Victor Nuttens, Georg Schramm, Yves D’Asseler, Michel Koole
Next-generation SPECT/CT systems with CdZnTe (CZT) digital detectors in a ring-like setup are emerging to perform quantitative Lu-177 SPECT imaging in clinical routine. It is essential to assess how the shorter acquisition time might affect the image quality and uncertainty on the mean absorbed dose of the tumors and organs at risk compared to a conventional system. A NEMA Image Quality phantom was
-
Sequential deep learning image enhancement models improve diagnostic confidence, lesion detectability, and image reconstruction time in PET EJNMMI Phys. (IF 4.0) Pub Date : 2024-03-15 Meghi Dedja, Abolfazl Mehranian, Kevin M. Bradley, Matthew D. Walker, Patrick A. Fielding, Scott D. Wollenweber, Robert Johnsen, Daniel R. McGowan
Investigate the potential benefits of sequential deployment of two deep learning (DL) algorithms namely DL-Enhancement (DLE) and DL-based time-of-flight (ToF) (DLT). DLE aims to enhance the rapidly reconstructed ordered-subset-expectation-maximisation algorithm (OSEM) images towards block-sequential-regularised-expectation-maximisation (BSREM) images, whereas DLT aims to improve the quality of BSREM
-
Reduction of [68Ga]Ga-DOTA-TATE injected activity for digital PET/MR in comparison with analogue PET/CT EJNMMI Phys. (IF 4.0) Pub Date : 2024-03-15 Christina P. W. Cox, Tessa Brabander, Erik Vegt, Quido G. de Lussanet de la Sablonière, Laura H. Graven, Frederik A. Verburg, Marcel Segbers
New digital detectors and block-sequential regularized expectation maximization (BSREM) reconstruction algorithm improve positron emission tomography (PET)/magnetic resonance (MR) image quality. The impact on image quality may differ from analogue PET/computed tomography (CT) protocol. The aim of this study is to determine the potential reduction of injected [68Ga]Ga-DOTA-TATE activity for digital
-
155Tb production by cyclotrons: what level of 155Gd enrichment allows clinical applications? EJNMMI Phys. (IF 4.0) Pub Date : 2024-03-15 Francesca Barbaro, Luciano Canton, Nikolay Uzunov, Laura De Nardo, Laura Melendez-Alafort
155Tb represents a potentially useful radionuclide for diagnostic medical applications, but its production remains a challenging problem, in spite of the fact that many production routes have been already investigated and tested. A recent experimental campaign, conducted with low-energy proton beams impinging on a 155Gd target with 91.9% enrichment, demonstrated a significant co-production of 156gTb
-
Validation of image-derived input function using a long axial field of view PET/CT scanner for two different tracers EJNMMI Phys. (IF 4.0) Pub Date : 2024-03-13 Xavier Palard-Novello, Denise Visser, Nelleke Tolboom, Charlotte L. C. Smith, Gerben Zwezerijnen, Elsmarieke van de Giessen, Marijke E. den Hollander, Frederik Barkhof, Albert D. Windhorst, Bart NM van Berckel, Ronald Boellaard, Maqsood Yaqub
Accurate image-derived input function (IDIF) from highly sensitive large axial field of view (LAFOV) PET/CT scanners could avoid the need of invasive blood sampling for kinetic modelling. The aim is to validate the use of IDIF for two kinds of tracers, 3 different IDIF locations and 9 different reconstruction settings. Eight [18F]FDG and 10 [18F]DPA-714 scans were acquired respectively during 70 and
-
Development and validation of a prognostic nomogram model in locally advanced NSCLC based on metabolic features of PET/CT and hematological inflammatory indicators EJNMMI Phys. (IF 4.0) Pub Date : 2024-03-05 Congjie Wang, Jian Fang, Tingshu Jiang, Shanliang Hu, Ping Wang, Xiuli Liu, Shenchun Zou, Jun Yang
We combined the metabolic features of 18F-FDG-PET/CT and hematological inflammatory indicators to establish a predictive model of the outcomes of patients with locally advanced non-small cell lung cancer (LA-NSCLC) receiving concurrent chemoradiotherapy. A predictive nomogram was developed based on sex, CEA, systemic immune-inflammation index (SII), mean SUV (SUVmean), and total lesion glycolysis (TLG)
-
Clinical feasibility study of early 30-minute dynamic FDG-PET scanning protocol for patients with lung lesions EJNMMI Phys. (IF 4.0) Pub Date : 2024-03-05 Fen Du, Xieraili Wumener, Yarong Zhang, Maoqun Zhang, Jiuhui Zhao, Jinpeng Zhou, Yiluo Li, Bin Huang, Rongliang Wu, Zeheng Xia, Zhiheng Yao, Tao Sun, Ying Liang
This study aimed to evaluate the clinical feasibility of early 30-minute dynamic 2-deoxy-2-[18F]fluoro-D-glucose (18F-FDG) positron emission tomography (PET) scanning protocol for patients with lung lesions in comparison to the standard 65-minute dynamic FDG-PET scanning as a reference. Dynamic 18F-FDG PET images of 146 patients with 181 lung lesions (including 146 lesions confirmed by histology) were
-
Correction: Feasibility study of a SiPM-fiber detector for non-invasive measurement of arterial input function for preclinical and clinical positron emission tomography EJNMMI Phys. (IF 4.0) Pub Date : 2024-03-04 Sara de Scals, Luis Mario Fraile, José Manuel Udías, Laura Martínez Cortés, Marta Oteo, Miguel Ángel Morcillo, José Luis Carreras-Delgado, María Nieves Cabrera-Martín, Samuel España
Correction: EJNMMI Phys11, 12 (2024). https://doi.org/10.1186/s40658-024-00618-2 Following publication of the original article [1], the authors requested to update the Funding section. The original Funding sections was: This work was funded by the Universidad Complutense de Madrid under Project PR27/21 − 009 and by the Ministerio de Ciencia e Innovación under Project TED2021-129933B-C21. S. España
-
Effect of kilovoltage and quality reference mAs on CT-based attenuation correction in 177Lu SPECT/CT imaging: a phantom study EJNMMI Phys. (IF 4.0) Pub Date : 2024-02-26 Maikol Salas-Ramirez, Julian Leube, Michael Lassmann, Johannes Tran-Gia
CT-based attenuation correction (CT-AC) plays a major role in accurate activity quantification by SPECT/CT imaging. However, the effect of kilovoltage peak (kVp) and quality-reference mAs (QRM) on the attenuation coefficient image (μ-map) and volume CT dose index (CTDIvol) have not yet been systematically evaluated. Therefore, the aim of this study was to fill this gap and investigate the influence
-
Kinetic 18F-FDG PET/CT imaging of hepatocellular carcinoma: a dual input four-compartment model EJNMMI Phys. (IF 4.0) Pub Date : 2024-02-22 Tao Wang, Yinglei Deng, Sidan Wang, Jianfeng He, Shaobo Wang
The endoplasmic reticulum plays an important role in glucose metabolism and has not been explored in the kinetic estimation of hepatocellular carcinoma (HCC) via 18F-fluoro-2-deoxy-d-glucose PET/CT. A dual-input four-compartment (4C) model, regarding endoplasmic reticulum was preliminarily used for kinetic estimation to differentiate 28 tumours from background liver tissue from 24 patients with HCC
-
Fit of biokinetic data in molecular radiotherapy: a machine learning approach EJNMMI Phys. (IF 4.0) Pub Date : 2024-02-22 Davide Ciucci, Bartolomeo Cassano, Salvatore Donatiello, Federica Martire, Antonio Napolitano, Claudia Polito, Elena Solfaroli Camillocci, Gianluca Cervino, Ludovica Pungitore, Claudio Altini, Maria Felicia Villani, Milena Pizzoferro, Maria Carmen Garganese, Vittorio Cannatà
In literature are reported different analytical methods (AM) to choose the proper fit model and to fit data of the time-activity curve (TAC). On the other hand, Machine Learning algorithms (ML) are increasingly used for both classification and regression tasks. The aim of this work was to investigate the possibility of employing ML both to classify the most appropriate fit model and to predict the
-
Quantitative calibration of Tb-161 SPECT/CT in view of personalised dosimetry assessment studies EJNMMI Phys. (IF 4.0) Pub Date : 2024-02-19 Lachlan McIntosh, Price Jackson, Brittany Emmerson, James P. Buteau, Ramin Alipour, Grace Kong, Michael S. Hofman
Terbium-161 (161Tb)-based radionuclide therapy poses an alternative to current Lutetium-177 (177Lu) approaches with the additional benefit of secondary Auger and conversion electron emissions capable of delivering high doses of localised damage to micro-metastases including single cells. Quantitative single-photon emission computed tomography, paired with computed tomography (SPECT/CT), enables quantitative
-
Phantom study and clinical application of total-body 18F-FDG PET/CT imaging: How to use small voxel imaging better? EJNMMI Phys. (IF 4.0) Pub Date : 2024-02-15 Chi Qi, Xiuli Sui, Haojun Yu, Siyang Wang, Yan Hu, Hongyan Sun, Xinlan Yang, Yihan Wang, Yun Zhou, Hongcheng Shi
Conventional PET/CT imaging reconstruction is typically performed using voxel size of 3.0–4.0 mm in three axes. It is hypothesized that a smaller voxel sizes could improve the accuracy of small lesion detection. This study aims to explore the advantages and conditions of small voxel imaging on clinical application. Both NEMA IQ phantom and 30 patients with an injected dose of 3.7 MBq/kg were scanned
-
How to obtain the image-derived blood concentration from 89Zr-immuno-PET scans EJNMMI Phys. (IF 4.0) Pub Date : 2024-02-07 Jessica E. Wijngaarden, Amina Ahbari, Johanna E. E. Pouw, Henri N. J. M. Greuter, Idris Bahce, Gerben J. C. Zwezerijnen, Daniëlle J. Vugts, Guus A. M. S. van Dongen, Ronald Boellaard, C. Willemien Menke-van der Houven van Oordt, Marc C. Huisman
PET scans using zirconium-89 labelled monoclonal antibodies (89Zr-mAbs), known as 89Zr-immuno-PET, are made to measure uptake in tumour and organ tissue. Uptake is related to the supply of 89Zr-mAbs in the blood. Measuring activity concentrations in blood, however, requires invasive blood sampling. This study aims to identify the best delineation strategy to obtain the image-derived blood concentration
-
Anatomy-based correction of kidney PVE on \(^{177}\text{Lu}\) SPECT images EJNMMI Phys. (IF 4.0) Pub Date : 2024-02-06 Julien Salvadori, Oreste Allegrini, Thomas Opsommer, Josefina Carullo, David Sarrut, Clemence Porot, Florian Ritzenthaler, Philippe Meyer, Izzie-Jacques Namer
In peptide receptor radionuclide therapy (PRRT), accurate quantification of kidney activity on post-treatment SPECT images paves the way for patient-specific treatment. Due to the limited spatial resolution of SPECT images, the partial volume effect (PVE) is a significant source of quantitative bias. In this study, we aimed to evaluate the performance and robustness of anatomy-based partial volume
-
Prediction of [177Lu]Lu-DOTA-TATE therapy response using the absorbed dose estimated from [177Lu]Lu-DOTA-TATE SPECT/CT in patients with metastatic neuroendocrine tumour EJNMMI Phys. (IF 4.0) Pub Date : 2024-02-05 Sejin Ha, Yong-il Kim, Jungsu S. Oh, Changhoon Yoo, Baek-Yeol Ryoo, Jin-Sook Ryu
Peptide receptor radionuclide therapy (PRRT) with [177Lu]Lu-DOTA-TATE has shown efficacy in patients with metastatic neuroendocrine tumours (NETs). Personalised dosimetry is crucial to optimise treatment outcomes and minimise adverse events. In this study, we investigated the correlation between the tumour-absorbed dose (TAD) estimated from [177Lu]Lu-DOTA-TATE SPECT/CT and the therapeutic response
-
Validation of a discovery MI 4-ring model according to the NEMA NU 2-2018 standards: from Monte Carlo simulations to clinical-like reconstructions EJNMMI Phys. (IF 4.0) Pub Date : 2024-01-31 Antoine Merlet, Benoît Presles, Kuan-Hao Su, Julien Salvadori, Farzam Sayah, Hanieh Jozi, Alexandre Cochet, Jean-Marc Vrigneaud
We propose a comprehensive evaluation of a Discovery MI 4-ring (DMI) model, using a Monte Carlo simulator (GATE) and a clinical reconstruction software package (PET toolbox). The following performance characteristics were compared with actual measurements according to NEMA NU 2-2018 guidelines: system sensitivity, count losses and scatter fraction (SF), coincidence time resolution (CTR), spatial resolution
-
Feasibility study of a SiPM-fiber detector for non-invasive measurement of arterial input function for preclinical and clinical positron emission tomography EJNMMI Phys. (IF 4.0) Pub Date : 2024-01-31 Sara de Scals, Luis Mario Fraile, José Manuel Udías, Laura Martínez Cortés, Marta Oteo, Miguel Ángel Morcillo, José Luis Carreras-Delgado, María Nieves Cabrera-Martín, Samuel España
Pharmacokinetic positron emission tomography (PET) studies rely on the measurement of the arterial input function (AIF), which represents the time-activity curve of the radiotracer concentration in the blood plasma. Traditionally, obtaining the AIF requires invasive procedures, such as arterial catheterization, which can be challenging, time-consuming, and associated with potential risks. Therefore
-
Simultaneous estimation of a model-derived input function for quantifying cerebral glucose metabolism with [18F]FDG PET EJNMMI Phys. (IF 4.0) Pub Date : 2024-01-29 Lucas Narciso, Graham Deller, Praveen Dassanayake, Linshan Liu, Samara Pinto, Udunna Anazodo, Andrea Soddu, Keith St Lawrence
Quantification of the cerebral metabolic rate of glucose (CMRGlu) by dynamic [18F]FDG PET requires invasive arterial sampling. Alternatives to using an arterial input function (AIF) include the simultaneous estimation (SIME) approach, which models the image-derived input function (IDIF) by a series of exponentials with coefficients obtained by fitting time activity curves (TACs) from multiple volumes-of-interest
-
Evaluating a radiotherapy deep learning synthetic CT algorithm for PET-MR attenuation correction in the pelvis EJNMMI Phys. (IF 4.0) Pub Date : 2024-01-29 Jonathan J. Wyatt, Sandeep Kaushik, Cristina Cozzini, Rachel A. Pearson, George Petrides, Florian Wiesinger, Hazel M. McCallum, Ross J. Maxwell
Positron emission tomography–magnetic resonance (PET-MR) attenuation correction is challenging because the MR signal does not represent tissue density and conventional MR sequences cannot image bone. A novel zero echo time (ZTE) MR sequence has been previously developed which generates signal from cortical bone with images acquired in 65 s. This has been combined with a deep learning model to generate
-
Insertion of synthetic lesions on patient data: a method for evaluating clinical performance differences between PET systems EJNMMI Phys. (IF 4.0) Pub Date : 2024-01-22 Quentin Maronnier, Nesrine Robaine, Léonor Chaltiel, Lawrence O. Dierickx, Thibaut Cassou-Mounat, Marie Terroir, Lavinia Vija, Delphine Vallot, Séverine Brillouet, Chloé Lamesa, Thomas Filleron, Olivier Caselles, Frédéric Courbon
Performance assessment of positron emission tomography (PET) scanners is crucial to guide clinical practice with efficiency. We have already introduced and experimentally evaluated a simulation method allowing the creation of a controlled ground truth for system performance assessment. In the current study, the goal was to validate the method using patient data and demonstrate its relevance to assess
-
3D printed non-uniform anthropomorphic phantoms for quantitative SPECT EJNMMI Phys. (IF 4.0) Pub Date : 2024-01-22 Lovisa Jessen, Johan Gustafsson, Michael Ljungberg, Selma Curkic-Kapidzic, Muris Imsirovic, Katarina Sjögreen-Gleisner
A 3D printing grid-based method was developed to construct anthropomorphic phantoms with non-uniform activity distributions, to be used for evaluation of quantitative SPECT images. The aims were to characterize the grid-based method and to evaluate its capability to provide realistically shaped phantoms with non-uniform activity distributions. Characterization of the grid structures was performed by
-
Investigation of PET image quality with acquisition time/bed and enhancement of lesion quantification accuracy through deep progressive learning EJNMMI Phys. (IF 4.0) Pub Date : 2024-01-10 Hongxing Yang, Shihao Chen, Ming Qi, Wen Chen, Qing Kong, Jianping Zhang, Shaoli Song
To improve the PET image quality by a deep progressive learning (DPL) reconstruction algorithm and evaluate the DPL performance in lesion quantification. We reconstructed PET images from 48 oncological patients using ordered subset expectation maximization (OSEM) and deep progressive learning (DPL) methods. The patients were enrolled into three overlapped studies: 11 patients for image quality assessment
-
Comparison of Otsu and an adapted Chan–Vese method to determine thyroid active volume using Monte Carlo generated SPECT images EJNMMI Phys. (IF 4.0) Pub Date : 2024-01-08 Jonas Högberg, Christoffer Andersén, Tobias Rydén, Jakob H. Lagerlöf
The Otsu method and the Chan–Vese model are two methods proven to perform well in determining volumes of different organs and specific tissue fractions. This study aimed to compare the performance of the two methods regarding segmentation of active thyroid gland volumes, reflecting different clinical settings by varying the parameters: gland size, gland activity concentration, background activity concentration
-
The D-SPECT SH reconstruction protocol: improved quantification of small left ventricle volumes EJNMMI Phys. (IF 4.0) Pub Date : 2024-01-08 Yan Huang, Han Zhang, Xueping Hu, Shanshan Qin, Fan Hu, Yuchen Li, Haidong Cai, Kuangyu Shi, Fei Yu
Due to spatial resolution limitations, conventional NaI-SPECT typically overestimates the left ventricular (LV) ejection fraction (EF) in patients with small LV volumes. The purpose of this study was to explore the clinical application value of the small heart (SH) reconstruction protocol embedded in the postprocessing procedure of D-SPECT. We retrospectively analyzed patients who undergo both D-SPECT
-
The determination of the optimal threshold on measurement of thyroid volume using quantitative SPECT/CT for Graves' hyperthyroidism EJNMMI Phys. (IF 4.0) Pub Date : 2024-01-05 Chengpeng Gong, Yajing Zhang, Fei Feng, Mengmeng Hu, Kun Li, Rundong Pi, Hua Shu, Rongmei Tang, Xiaoli Wang, Shilin Tan, Fan Hu, Jia Hu
To investigate the optimal threshold for measuring thyroid volume in patients with Grave's hyperthyroidism (GH) by SPECT/CT. A 53 mL butterfly-shaped hollow container made of two 45-degree transparent elbows was put into a NEMA IEC phantom tank. The butterfly-shaped container and the tank were then filled with Na99mTcO4 of different radioactive concentrations, respectively, which could simulate thyroid
-
Biodistribution and radiation dosimetry of 124I-mIBG in adult patients with neural crest tumours and extrapolation to paediatric models EJNMMI Phys. (IF 4.0) Pub Date : 2024-01-03 Alexandros Moraitis, Walter Jentzen, Gloria Reiter, Jochen Schmitz, Thorsten Dirk Pöppel, Manuel Weber, Ken Herrmann, Wolfgang Peter Fendler, Pedro Fragoso Costa, Andreas Bockisch, David Kersting
Positron emission tomography (PET) using 124I-mIBG has been established for imaging and pretherapeutic dosimetry. Here, we report the first systematic analysis of the biodistribution and radiation dosimetry of 124I-mIBG in patients with neural crest tumours and project the results to paediatric patient models. Adult patients with neural crest tumours who underwent sequential 124I-mIBG PET were included
-
Feasibility of 177Lu activity quantification using a small portable CZT-based gamma-camera EJNMMI Phys. (IF 4.0) Pub Date : 2024-01-03 Daniel Roth, Erik Larsson, Joanna Strand, Michael Ljungberg, Katarina Sjögreen Gleisner
In image processing for activity quantification, the end goal is to produce a metric that is independent of the measurement geometry. Photon attenuation needs to be accounted for and can be accomplished utilizing spectral information, avoiding the need of additional image acquisitions. The aim of this work is to investigate the feasibility of 177Lu activity quantification with a small CZT-based hand-held
-
Reducing pediatric total-body PET/CT imaging scan time with multimodal artificial intelligence technology EJNMMI Phys. (IF 4.0) Pub Date : 2024-01-02 Qiyang Zhang, Yingying Hu, Chao Zhou, Yumo Zhao, Na Zhang, Yun Zhou, Yongfeng Yang, Hairong Zheng, Wei Fan, Dong Liang, Zhanli Hu
This study aims to decrease the scan time and enhance image quality in pediatric total-body PET imaging by utilizing multimodal artificial intelligence techniques. A total of 270 pediatric patients who underwent total-body PET/CT scans with a uEXPLORER at the Sun Yat-sen University Cancer Center were retrospectively enrolled. 18F-fluorodeoxyglucose (18F-FDG) was administered at a dose of 3.7 MBq/kg
-
90Y SPECT scatter estimation and voxel dosimetry in radioembolization using a unified deep learning framework EJNMMI Phys. (IF 4.0) Pub Date : 2023-12-13 Yixuan Jia, Zongyu Li, Azadeh Akhavanallaf, Jeffrey A. Fessler, Yuni K. Dewaraja
90Y SPECT-based dosimetry following radioembolization (RE) in liver malignancies is challenging due to the inherent scatter and the poor spatial resolution of bremsstrahlung SPECT. This study explores a deep-learning-based absorbed dose-rate estimation method for 90Y that mitigates the impact of poor SPECT image quality on dosimetry and the accuracy–efficiency trade-off of Monte Carlo (MC)-based scatter
-
SAFIR-I: first NEMA NU 4-2008-based performance characterization EJNMMI Phys. (IF 4.0) Pub Date : 2023-12-12 Pascal Bebié, Werner Lustermann, Jan Debus, Christian Ritzer, Günther Dissertori, Bruno Weber
Small Animal Fast Insert for MRI detector I (SAFIR-I) is a novel Positron Emission Tomography insert for a $$7\,\hbox {T}$$ Bruker BioSpec 70/30 Ultra Shield Refrigerated Magnetic Resonance Imaging (MRI) system. It facilitates truly simultaneous quantitative imaging in mice and rats at injected activities as high as $$500\,\hbox {MBq}$$ . Exploitation of the resulting high count rates enables quick
-
SLIC-Occ: functional segmentation of occupancy images improves precision of EC50 images EJNMMI Phys. (IF 4.0) Pub Date : 2023-12-11 Alaaddin Ibrahimy, Jocelyn Hoye, Hao Wu, Bart de Laat, Su Jin Kim, David L. Wilson, Evan D. Morris
Drug occupancy studies with positron emission tomography imaging are used routinely in early phase drug development trials. Recently, our group introduced the Lassen Plot Filter, an extended version of the standard Lassen plot to estimate voxel-level occupancy images. Occupancy images can be used to create an EC50 image by applying an Emax model at each voxel. Our goal was to apply functional clustering
-
Clinical application of a population-based input function (PBIF) for a shortened dynamic whole-body FDG-PET/CT protocol in patients with metastatic melanoma treated by immunotherapy EJNMMI Phys. (IF 4.0) Pub Date : 2023-12-08 Mathieu Pavoine, Philippe Thuillier, Nicolas Karakatsanis, Delphine Legoupil, Karim Amrane, Romain Floch, Romain Le Pennec, Pierre-Yves Salaün, Ronan Abgral, David Bourhis
The aim was to investigate the feasibility of a shortened dynamic whole-body (dWB) FDG-PET/CT protocol and Patlak imaging using a population-based input function (PBIF), instead of an image-derived input function (IDIF) across the 60-min post-injection period, and study its effect on the FDG influx rate (Ki) quantification in patients with metastatic melanoma (MM) undergoing immunotherapy. Thirty-seven
-
Accurate image derived input function in [18F]SynVesT-1 mouse studies using isoflurane and ketamine/xylazine anesthesia EJNMMI Phys. (IF 4.0) Pub Date : 2023-12-06 Alan Miranda, Daniele Bertoglio, Steven Staelens, Jeroen Verhaeghe
Kinetic modeling in positron emission tomography (PET) requires measurement of the tracer plasma activity in the absence of a suitable reference region. To avoid invasive blood sampling, the use of an image derived input function has been proposed. However, an accurate delineation of the blood pool region in the PET image is necessary to obtain unbiased blood activity. Here, to perform brain kinetic
-
Optimisation of the air fraction correction for lung PET/CT: addressing resolution mismatch EJNMMI Phys. (IF 4.0) Pub Date : 2023-12-05 Francesca Leek, Cameron Anderson, Andrew P. Robinson, Robert M. Moss, Joanna C. Porter, Helen S. Garthwaite, Ashley M. Groves, Brian F. Hutton, Kris Thielemans
Increased pulmonary $$^{18}{}$$ F-FDG metabolism in patients with idiopathic pulmonary fibrosis, and other forms of diffuse parenchymal lung disease, can predict measurements of health and lung physiology. To improve PET quantification, voxel-wise air fractions (AF) determined from CT can be used to correct for variable air content in lung PET/CT. However, resolution mismatches between PET and CT can
-
16-channel SiPM high-frequency readout with time-over-threshold discrimination for ultrafast time-of-flight applications EJNMMI Phys. (IF 4.0) Pub Date : 2023-12-04 Vanessa Nadig, Matthias Hornisch, Jakob Oehm, Katrin Herweg, Volkmar Schulz, Stefan Gundacker
Over the past five years, ultrafast high-frequency (HF) readout concepts have advanced the timing performance of silicon photomultipliers (SiPMs). The shown impact in time-of-flight (TOF) techniques can further push the limits in light detection and ranging (LiDAR), time-of-flight positron-emission tomography (TOF-PET), time-of-flight computed tomography (TOF-CT) or high-energy physics (HEP). However
-
A simulation study of the system characteristics for a long axial FOV PET design based on monolithic BGO flat panels compared with a pixelated LSO cylindrical design EJNMMI Phys. (IF 4.0) Pub Date : 2023-12-01 Meysam Dadgar, Jens Maebe, Maya Abi Akl, Boris Vervenne, Stefaan Vandenberghe
Although a new generation of tomographs with a longer axial field-of-view called total-body PET have been developed, they are not widely utilized due to their high cost compared to conventional scanners. The newly designed walk-through total-body PET scanner is introduced as a high-throughput and cost-efficient alternative to total-body PET scanners, by making use of a flat panel geometry and lower
-
Correction: Precision dosimetry in yttrium-90 radioembolization through CT imaging of radiopaque microspheres in a rabbit liver model EJNMMI Phys. (IF 4.0) Pub Date : 2023-11-29 E. Courtney Henry, Matthew Strugari, George Mawko, Kimberly Brewer, David Liu, Andrew C. Gordon, Jeffrey N. Bryan, Charles Maitz, James J. Karnia, Robert Abraham, S. Cheenu Kappadath, Alasdair Syme
In this article [1], James J. Karnia at affiliation “Department of Veterinary Medicine and Surgery, University of Missouri, Columbia, MO, USA” was missing from and has been added to the author list. The Authors’ Contributions section has been revised to: ECH performed the data analysis and wrote the manuscript. MS and KB calculated and validated the dose-voxel kernels. DL provided editorial review
-
On the use of solid 133Ba sources as surrogate for liquid 131I in SPECT/CT calibration: a European multi-centre evaluation EJNMMI Phys. (IF 4.0) Pub Date : 2023-11-23 Johannes Tran-Gia, Ana M. Denis-Bacelar, Kelley M. Ferreira, Andrew P. Robinson, Christophe Bobin, Lara M. Bonney, Nicholas Calvert, Sean M. Collins, Andrew J. Fenwick, Domenico Finocchiaro, Federica Fioroni, Katerina Giannopoulou, Elisa Grassi, Warda Heetun, Stephanie J. Jewitt, Maria Kotzasarlidou, Michael Ljungberg, Valérie Lourenço, Daniel R. McGowan, Jamie Mewburn-Crook, Benoit Sabot, James Scuffham
Commissioning, calibration, and quality control procedures for nuclear medicine imaging systems are typically performed using hollow containers filled with radionuclide solutions. This leads to multiple sources of uncertainty, many of which can be overcome by using traceable, sealed, long-lived surrogate sources containing a radionuclide of comparable energies and emission probabilities. This study
-
Parametric and non-parametric Poisson regression for modelling of the arterial input function in positron emission tomography EJNMMI Phys. (IF 4.0) Pub Date : 2023-11-21 Granville J. Matheson, Liner Ge, Mengyu Zhang, Bingyu Sun, Yuqi Tu, Francesca Zanderigo, Anton Forsberg Morèn, R. Todd Ogden
Full quantification of Positron Emission Tomography (PET) requires an arterial input function (AIF) for measurement of certain targets, or using particular radiotracers, or for the quantification of specific outcome measures. The AIF represents the measurement of radiotracer concentrations in the arterial blood plasma over the course of the PET examination. Measurement of the AIF is prone to error
-
An automatic pipeline for PET/MRI attenuation correction validation in the brain EJNMMI Phys. (IF 4.0) Pub Date : 2023-11-14 Mahdjoub Hamdi, Chunwei Ying, Hongyu An, Richard Laforest
Challenges in PET/MRI quantitative accuracy for neurological uses arise from PET attenuation correction accuracy. We proposed and evaluated an automatic pipeline to assess the quantitative accuracy of four MRI-derived PET AC methods using analytically simulated PET brain lesions and ROIs as ground truth for PET activity. Our proposed pipeline, integrating a synthetic lesion insertion tool and the FreeSurfer
-
Radiation exposure assessment of nuclear medicine staff administering [177Lu]Lu-DOTA-TATE with active and passive dosimetry EJNMMI Phys. (IF 4.0) Pub Date : 2023-11-14 Mercedes Riveira-Martin, Lara Struelens, José Muñoz Iglesias, Werner Schoonjans, Olga Tabuenca, José Manuel Nogueiras, Francisco Javier Salvador Gómez, Antonio López Medina
The use of lutetium-177 (177Lu)-based radiopharmaceuticals in peptide receptor nuclear therapy is increasing, but so is the number of nuclear medicine workers exposed to higher levels of radiation. In recent years, [177Lu]Lu-DOTA-TATE has begun to be widely used for the treatment of neuroendocrine tumours. However, there are few studies evaluating the occupational radiation exposure during its administration
-
Replacing Lu-177 with Tb-161 in DOTA-TATE and PSMA-617 therapy: potential dosimetric implications for activity selection EJNMMI Phys. (IF 4.0) Pub Date : 2023-11-10 Frederik A. Verburg, Erik de Blois, Stijn Koolen, Mark W. Konijnenberg
To explore the dosimetric effect of substituting Lu-177 with Tb-161 in targeted radionuclide therapy (TRT) using the registered tracers DOTA-TATE and PSMA-617. Using established kinetic data for [177Lu]Lu-DOTA-TATE and [177Lu]Lu-PSMA-617, radiation absorbed doses to typical tumour lesion as well as non-target tissues ([177Lu]Lu-DOTA-TATE: kidneys, spleen and liver, [177Lu]Lu-PSMA-617: kidneys, liver
-
Harmonization of brain PET images in multi-center PET studies using Hoffman phantom scan EJNMMI Phys. (IF 4.0) Pub Date : 2023-10-31 Mahnaz Shekari, Eline E. Verwer, Maqsood Yaqub, Marcel Daamen, Christopher Buckley, Giovanni B. Frisoni, Pieter Jelle Visser, Gill Farrar, Frederik Barkhof, Juan Domingo Gispert, Ronald Boellaard
Image harmonization has been proposed to minimize heterogeneity in brain PET scans acquired in multi-center studies. However, standard validated methods and software tools are lacking. Here, we assessed the performance of a framework for the harmonization of brain PET scans in a multi-center European clinical trial. Hoffman 3D brain phantoms were acquired in 28 PET systems and reconstructed using site-specific
-
Combining deep learning with a kinetic model to predict dynamic PET images and generate parametric images EJNMMI Phys. (IF 4.0) Pub Date : 2023-10-24 Ganglin Liang, Jinpeng Zhou, Zixiang Chen, Liwen Wan, Xieraili Wumener, Yarong Zhang, Dong Liang, Ying Liang, Zhanli Hu
Dynamic positron emission tomography (PET) images are useful in clinical practice because they can be used to calculate the metabolic parameters (Ki) of tissues using graphical methods (such as Patlak plots). Ki is more stable than the standard uptake value and has a good reference value for clinical diagnosis. However, the long scanning time required for obtaining dynamic PET images, usually an hour
-
Ultra-low-dose CT for attenuation correction: dose savings and effect on PET quantification for protocols with and without tin filter EJNMMI Phys. (IF 4.0) Pub Date : 2023-10-20 Natalie Anne Bebbington, Kenneth Boye Christensen, Lone Lange Østergård, Paw Christian Holdgaard
Ultra-low-dose (ULD) computed tomography (CT) scans should be used when CT is performed only for attenuation correction (AC) of positron emission tomography (PET) data. A tin filter can be used in addition to the standard aluminium bowtie filter to reduce CT radiation dose to patients. The aim was to determine how low CT doses can be, when utilised for PET AC, with and without the tin filter, whilst
-
Optimization of Q.Clear reconstruction for dynamic 18F PET imaging EJNMMI Phys. (IF 4.0) Pub Date : 2023-10-20 Elisabeth Kirkeby Lysvik, Lars Tore Gyland Mikalsen, Mona-Elisabeth Rootwelt-Revheim, Kyrre Eeg Emblem, Trine Hjørnevik
Q.Clear, a Bayesian penalized likelihood reconstruction algorithm, has shown high potential in improving quantitation accuracy in PET systems. The Q.Clear algorithm controls noise during the iterative reconstruction through a β penalization factor. This study aimed to determine the optimal β-factor for accurate quantitation of dynamic PET scans. A Flangeless Esser PET Phantom with eight hollow spheres
-
Quantitative 177Lu SPECT/CT imaging for personalized dosimetry using a ring-shaped CZT-based camera EJNMMI Phys. (IF 4.0) Pub Date : 2023-10-18 Rachele Danieli, Martina Stella, Julian Leube, Johannes Tran-Gia, Clementine Marin, Carlos F. Uribe, Bruno Vanderlinden, Nick Reynaert, Patrick Flamen, Hugo Levillain
Dosimetry after radiopharmaceutical therapy with 177Lu (177Lu-RPT) relies on quantitative SPECT/CT imaging, for which suitable reconstruction protocols are required. In this study, we characterized for the first time the quantitative performance of a ring-shaped CZT-based camera using two different reconstruction algorithms: an ordered subset expectation maximization (OSEM) and a block sequential regularized
-
The effects of various penalty parameter values in Q.Clear algorithm for rectal cancer detection on 18F-FDG images using a BGO-based PET/CT scanner: a phantom and clinical study EJNMMI Phys. (IF 4.0) Pub Date : 2023-10-16 Fatemeh Sadeghi, Peyman Sheikhzadeh, Saeed Farzanehfar, Pardis Ghafarian, Yalda Moafpurian, Mohammadreza Ay
The Q.Clear algorithm is a fully convergent iterative image reconstruction technique. We hypothesize that different PET/CT scanners with distinct crystal properties will require different optimal settings for the Q.Clear algorithm. Many studies have investigated the improvement of the Q.Clear reconstruction algorithm on PET/CT scanner with LYSO crystals and SiPM detectors. We propose an optimum penalization