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Identification of hCA I, hCA II, AChE and BChE Inhibitory Properties of Some Norcantharimide Derivatives; Molecular Docking, SAR and in silico ADME Studies ChemistrySelect (IF 2.1) Pub Date : 2024-04-23 Leyla Polat Köse, Aytekin Köse
(3aR,4S,7R,7aS)‐2‐Alkyl/aryl‐3a,4,7,7a‐tetrahydro‐1H‐4,7‐epoxyisoindole‐1,3(2H)‐diones, which are norcantharimide derivatives, were synthesized and their effects on carbonic anhydrase I (hCA I) and II (hCA II), acetylcholinesterase (AChE), and butyrylcholinesterase (BChE) inhibitory activity were investigated. For enzyme activity studies, hCA I and II isoenzymes purified from human erythrocytes and
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Targeted Development of Pyrazoline Derivatives for Neurological Disorders: A Review ChemistrySelect (IF 2.1) Pub Date : 2024-04-23 Anurag Chauhan, Salahuddin Salahuddin, Avijit Mazumder, Rajnish Kumar, Mohamed Jawed Ahsan, Mohammad Shahar Yar, Ramish Maqsood, Kumar Singh
Pyrazolines are preferred to be stable heterocycles in medication development. It has been established from previous research that the 2‐pyrazolone scaffold is a common pattern that can be found in many pharmacologically significant therapeutic compounds. They are said to have a wide range of biological actions and have been thoroughly investigated by the scientific community. 2‐pyrazoline has been
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Oxidative and Colloidal Kinetics of Size‐Controlled Copper Structures through Surface Plasmon‐Regulated Examinations for Broadband Absorbance ChemistrySelect (IF 2.1) Pub Date : 2024-04-23 A. R. Indhu, Gnanaprakash Dharmalingam
Out of all the candidate plasmonic metals, copper has noteworthy optical characteristics and is also economically favourable for use. However, the stability of plasmonic copper nanomaterials against the loss of the plasmonic property is a setback. The present work is on the synthesis of oxidation‐stable copper micro/nanoparticles (CuMps/NPs) at ambient conditions with chosen precursors, antioxidizing
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Superior Catalytic Performance and Methanol Tolerance of Co@Mesoporous Graphene Nanocomposites toward Oxygen Reduction Reaction ChemistrySelect (IF 2.1) Pub Date : 2024-04-23 Fangying Yuan, Wei Chen, Lining Fan, Xiaoxiao Guo, Hui Zheng, Peng Zheng, Liang Zheng, Yang Zhang
The global energy crisis and growing concerns about environmental pollution have spurred researchers to explore eco‐friendly methods of generating clean energy. Previous studies have often relied on noble metal catalysts to facilitate oxygen reduction reactions (ORR) in energy production reactions. However, their high cost has limited their widespread adoption, making the development of highly active
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Unravelling the Design and Mechanism: Potential of Substituted Quinolines as PASTA subunit 4 Inhibitors for Antimicrobial Activity ChemistrySelect (IF 2.1) Pub Date : 2024-04-23 Kirti Sharma, Atul Sharma, Mohit Sanduja, Asim Kumar
The increasing incidences of antibiotic‐resistance in Microorganisms have become a critical global health challenge. Traditional treatments, often relying on multiple antibiotics, are plagued by issues like drug resistance, reduced effectiveness, and heightened toxicity. In response, there is a compelling demand for innovative anti‐microbial agents that offer novel mechanisms of action. The family
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2‐(1‐Methyl‐1H‐indazol‐5‐yl)‐N‐arylisonicotinamide Analogs: Synthesis, Anticancer Screening, SAR and ADMET Studies ChemistrySelect (IF 2.1) Pub Date : 2024-04-23 Umang P. Patel, Parth S. Unjiya, Ranjitsinh C. Dabhi, Hemal M. Parmar, Manish K. Shah
In this current research framework, we detailed the synthesis of ten novel 2‐(1‐methyl‐1H‐indazol‐5‐yl)‐N‐arylisonicotinamide analogs (3a–j). The synthesis of these compounds (3a–j) involved a three‐step process, employing the Suzuki‐Miyaura coupling reaction, which successfully linked 1‐methyl‐1H‐indazole with isonicotinamide to satisfactory yields. The synthesized compounds were characterized using
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VT‐NMR Analysis of Rotation‐Inversion of N‐(4‐hydroxybutyl)‐N‐(2,2,2‐trifluoroethyl) tert‐butyl Carbamate: Utilizing the −CH2CF3 Appendage as a Reporter on E/Z‐Isomerization ChemistrySelect (IF 2.1) Pub Date : 2024-04-23 Brian Jameson, Rainer Glaser
The rotational barrier about the CN carbamate bond of N‐(4‐hydroxybutyl)‐N‐(2,2,2‐trifluoroethyl) tert‐butyl carbamate 1 was determined by variable temperature (VT) 13C and 19F NMR spectroscopy. The −CH2CF3 appendage reports on rotational isomerism and allows for the observation of separate signals for the E‐ and Z‐ensembles at low temperature. The activation barrier for E/Z‐isomerization was quantified
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Synthesis of Benzimidazole Based 1,2,4‐Triazole Derivatives as Potential Anticancer Agents: In Silico Techniques ChemistrySelect (IF 2.1) Pub Date : 2024-04-23 Komal Chandrakar, Naveen Kumar Sureddy, Raju Chedupaka, Venkatesham Papisetti, S. P. Mahapatra, Santhosh Penta
Compounds with a 1,2,4–triazole scaffold serve an essential role in organic synthesis, particularly in the synthesis of bioactive organic compounds; thus, the development of new approaches for modifying this scaffold is a very interesting framework of this study. To contribute to the development of an efficient method for the conversion of anticancer triazoles, a novel series of benzimidazole based
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Novel CQDs/BiOI Microspheres with Gradient Oxygen Vacancies for Efficient Photocatalytic Performance Boosting by the Synergism of Reactive Oxygen and Iodine Species ChemistrySelect (IF 2.1) Pub Date : 2024-04-23 Jiangtao Niu, Yi Zhou, Jin Zhang, Wanhong He, Yinghong Zhou, Guihua Huang, Dujie Feng
The synergy of reactive oxidative species (ROSs: ⋅OH, ⋅O2− and 1O2) and reactive iodine species (RISs: ⋅I and ⋅I2−) is conclusive to driving organic pollutant degradation in various aquatic environments. Over the past years, rational design of Vis‐NIR responsive photocatalyst with enhanced photocatalytic performance has attracted drawing attention. Herein, CQDs/BiOI composites with up‐conversion photoluminescence
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Alkali Metal–Substitution–Induced Confinement Effect for Designing High Phase–Transition–Temperature Molecular–Based Compounds Exhibiting Strong Photoluminescence ChemistrySelect (IF 2.1) Pub Date : 2024-04-23 Zimu Li, Haoran Chen, Qingling Cao, Caihong Shi, Jieyu Zhu, Wenhe Zhong, Liang Tong, Qiangqiang Jia, Jiajia Zhao, Lizhuang Chen
Organic–inorganic hybrid phase–transition molecular materials have attracted increasing attention due to their excellent properties of combining inorganic and organic components. However, few research has been conducted on rare‐earth–based bimetallic organic–inorganic hybrids. Here, we successfully constructed a series of rare–earth–based organic–inorganic hybrid multifunctional materials, (C6H14N2)2EuX(NO3)6O2
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Sealing of Zeolite L Channels with Ethoxysilanes: Influence of Molecular Structure and Thermal Treatment ChemistrySelect (IF 2.1) Pub Date : 2024-04-23 Simon Lustenberger, Dominik Brühwiler
The suitability of silanes H2N(C3H6)Si(OC2H5)3‐x(CH3)x (x=0, 1, 2) for the sealing of zeolite pores has been investigated. The sealing efficiency was evaluated by observing the exit kinetics of the fluorescent dye resorufin from the one‐dimensional main channels of zeolite L (ZL). The best results in terms of sealing quality were obtained with x=0, indicating the importance of ensuring maximum probability
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Structural Optimization, Anti‐TNBC Activities Evaluation, and Molecular Docking of an Indolone Derivative from Periplaneta americana ChemistrySelect (IF 2.1) Pub Date : 2024-04-23 Qin‐Bin Jiang, Xu Li, Maierhaba Maimaitituerhong, Li‐Zhi Cheng, Yong‐Xian Cheng, Danling Huang
In our previous work, an indolone derivative ZL170 was isolated and identified from Periplaneta americana (P. americana). Based on its characteristic structure, we used it as a lead compound to carry out structural optimization and subsequent antitumor activity evaluation. In the present study, a series of novel indolone derivatives bearing thiazole scaffold were designed and synthesized, and their
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Synthesis and Characterization of Oxime Derivatives and their Some Transition Metal Complexes with Thiadiazole Groups: Biological Activities, and Molecular Docking Studies of the Ligands ChemistrySelect (IF 2.1) Pub Date : 2024-04-23 Ahmed Saleem Otaiwi, Ahmed Hamdi Mirghani, Hayrani Eren Bostancı, Ahmet Coskun, Hakan Tahtaci, Saban Uysal
This study involved the synthesis and investigation of the anticancer and antioxidant capabilities of six newly developed ligands generated from 1,3,4‐thiadiazole and diphenyl ether keto oxime which has never been synthesized before, together with their transition metal complexes. The obtained ligands were characterized using elemental analysis, FTIR, 1H NMR, 13C NMR, and mass spectroscopy. Polymeric
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A Chemometric–Assisted Voltammetric Method for Simultaneous Determination of Acetaminophen and Diclofenac ChemistrySelect (IF 2.1) Pub Date : 2024-04-23 Neda Azish, Eslam Pourbasheer, Hamideh Imanzadeh, Mandana Amiri
Diclofenac (DCF) and Acetaminophen (ACT) are among the most important nonsteroidal anti–inflammatory drugs (NSAIDs) that sought after for their antipyretic, analgesic, and anti‐inflammatory properties. In addition, ACT and DCF show synergistic activity toward pain relief. Therefore, appropriate analytical strategies are required for the simultaneous quantification of these NSAIDs in prescription drugs
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A Promising Therapeutic Scaffold Fusing Chalcone/Coumarin Targeting Colorectal Cancer: Design, Synthesis, Biological and ADME‐tox Modelling ChemistrySelect (IF 2.1) Pub Date : 2024-04-23 Camilo Ramírez‐Bedoya, Wilson Cardona‐Galeano, Angie Herrera‐Ramírez, Andrés F. Yepes
Eight novel compounds incorporating chalcone and coumarin features, namely chalcone‐coumarin‐ hybrid molecules, were designed, synthetized, and evaluated for their activity against human colorectal carcinoma SW480 cell line. According to the results observed, the hybrid with a 2,3‐dimetoxysubstitution pattern displayed the highest activity at the conditions evaluated, with an IC50 value of 25.18±1
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A Mild and Metal Free Effective Route for the Synthesis of the Benzofuro[3,2‐c]quinoline Frame Work via Pictet‐Spengler Reaction ChemistrySelect (IF 2.1) Pub Date : 2024-04-23 Anusha Vanga, Muppidi Subbarao, Chumui Debbarma, Mrutunjay Nayak, Kamalakar Reddy Kamireddy, K. Shiva Kumar
We have reported an effective, metal free, one‐pot methodology for synthesising benzofuro[3,2‐c]quinolines via a Pictet‐Spengler reaction under mild conditions in open air. Our approach has a few advantages over the traditional two‐component synthesis as it is step and atom economic, environmentally benign and a convergent synthetic method. We have discussed here the good substrate scope of this novel
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Optimized Method for High‐Quality RNA Extraction from Formalin‐Fixed Paraffin‐Embedded Tissues ChemistrySelect (IF 2.1) Pub Date : 2024-04-23 Mahintaj Dara, Mehdi Dianatpour, Navid Omidifar, Negar Azarpira, Amir Nili‐Ahmadabadi
RNA extraction from formalin‐fixed paraffin‐embedded tissues (FFPE) presents a notable challenge. Extracting RNA from FFPE tissues has been challenging due to RNA degradation and chemical bonding between RNA and proteins during the fixation process. This results in reduced concentration and quality of the extracted RNA from FFPE tissues, impacting subsequent downstream analyses. In this study, we present
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Synthesis and Reactions of 3‐Amino‐5,6‐Dimethyl‐l,2,4‐Triazine: DFT Studies, ADME Assay, and Molecular Docking on the new l,2,4‐Triazine Derivatives as Anticancer Agents. ChemistrySelect (IF 2.1) Pub Date : 2024-04-22 Aisha O. Hussain, Aisha Y. Hassan, Anhar Abdel‐Aziem, Eman S. Abou‐Amra
Two effective one‐pot synthesis procedures were proposed for the synthesis of 3‐amino‐5,6‐dimethyl‐l,2,4‐triazine under free solvent conditions; these methods included fusing the monohydrazide of biacetyl with either methyl carbamimidothioate (Method B) or cyanamide (Method C). Simple reaction conditions, an easy work‐up process, and facile separation characterize the ecologically friendly fusion process
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Direct Amide Formation via Carbamoylation of Aromatic Bromides using Heteropoly Acid and UV‐Light ChemistrySelect (IF 2.1) Pub Date : 2024-04-19 Myeonggeuk Kim, Liu‐lan Shen, Jin Hyun Jeong
We performed direct carbamoylation using heteropoly acid (HPA) photocatalysts with a Keggin structure under UV‐light. Carbamoyl radicals were generated via the decarboxylation of N,N‐disubstituted dimethyloxamic acid under these conditions. The HPA catalyst functioned as a photocatalyst when the dicarbonyl bond was broken, generating carbon dioxide. We found that disubstituted carbamoyl radicals readily
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New Ciprofloxacin–Pyrazolopyrimidine Hybrids as Topoisomerase IV and Gyrase Inhibitors against MRSA AUMC 261 ChemistrySelect (IF 2.1) Pub Date : 2024-04-19 Mohamed Samir, Mohamed Ramadan, Mostafa H. Abdelrahman, Mahmoud S. Abdelbaset, Mohamed Abdel‐Aziz, Hamada Mohamed Halby, Gamal El‐Din A. Abuo‐Rahma
Eleven novel ciprofloxacin–pyrazolopyrimidine hybrids 4 a–k were synthesized and structurally elucidated using NMR, elemental analysis, and mass spectrometry. The antibacterial screening showed that the newly synthesized compounds revealed a remarkable shifting of antibacterial activity from Gram–negative toward Gram–positive bacteria. Most of the synthesized hybrids displayed good to excellent activity
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Synthesis of cNDI‐Peptide‐Dimer as a G4 Cluster‐Selective Binder and its Interaction with G4 Dimer ChemistrySelect (IF 2.1) Pub Date : 2024-04-19 Kentaro Ono, Shinobu Sato, Shigeori Takenaka
The amino acid unit carrying cyclic naphthalene diimide (cNDI) was synthesized by linking the amino moiety of cNDI as a G4‐specific ligand with the γ‐carboxylic acid moiety of Fmoc‐Glu. cNDI‐peptide‐dimer, 1 was synthesized by peptide synthesizer using this unit. 1 exhibited an extremely strong binding constant of the order of 108 M−1 with telomeric G4 dimer, probably due to cooperative stacking of
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Colorimetric Silver Ion Detection Based on Silver Metallization of Gold Nanorods ChemistrySelect (IF 2.1) Pub Date : 2024-04-19 Marzieh Sepahvand, Forough Ghasemi
Despite the use of silver in various industries, this heavy metal can pose serious risks to living organisms and the environment. Therefore, the development of simple measurement strategies for detection of silver ions (Ag+) with high sensitivity is of great importance. In this research, gold nanorods (AuNRs) have been used as indicator element in colorimetric sensor, which provides the possibility
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Easily Prepared Wood–Derived Hierarchically Porous Carbon for High–Performance Supercapacitors ChemistrySelect (IF 2.1) Pub Date : 2024-04-19 Yali Zhang, Yifeng Liu, Xiaoliang Wu
Hierarchical porous carbon exhibits enormous application potential in the field of energy storage. In this paper, we develop a facile method to prepare hierarchical porous carbon (HPC) derived from wood powder and using KMnO4 as the activator. The optimized HPC‐600 samples possess the large specific surface area with hierarchical porous structure and massive oxygen–containing functional groups. The
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Silver Sulfide Anchored Anatase TiO2 Nanoparticles for Ultrafast Degradation of Selective Textile Dyes ChemistrySelect (IF 2.1) Pub Date : 2024-04-19 Govindhasamy Murugadoss, Nachimuthu Venkatesh, Jothiramalingam Rajabathar, Narthana Kandhasamy, Rajesh Kumar Manavalan
The surface modification of the TiO2 with selective narrow band gap of metal or metal sulfide is an attractive attention in recent years. Herein, tiny Ag2S nanoparticles are well anchored on the TiO2 surface by a cost‐effective chemical precipitation method for efficient photocatalytic activity. The decoration of Ag2S nanoparticles is clearly identified through electron microscopy studies. The UV‐Vis
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Nanostructures Originated from Grafting Amino Group Containing Biomolecules on Graphene Oxide ChemistrySelect (IF 2.1) Pub Date : 2024-04-19 Mojtaba Ghorbani, Aliakbar Tarlani, Saeed Taghvaei‐Ganjali, Mercede Malekzade
With the aim of obtaining new composites from graphene oxide for a new biological application, it urged us to select some amine containing molecules namely purpald, mafenide acetate and fluvoxamine for grafting that was resulted to the formation of purpald‐grafted graphene oxide, mafenide‐grafted graphene oxide and fluvoxamine‐grafted graphene oxide, respectively. These novel nanocomposites were evaluated
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A Novel Approach for Synthesizing Ultra–Small Silver Nanoparticles Using Covalent Organic Frameworks as Template, Stabilizer and Reductant at Room Temperature ChemistrySelect (IF 2.1) Pub Date : 2024-04-19 Ningning Yuan, Tong Su, Le Zhang, Dong Li, Jianye Li, Tingchun Zhu, Junping Hu, Haobo Guo, Yirui Liu, Nana Liu, Wenpeng Han, Decui Yao
The preparation of ultra–small silver nanoparticles (average diameter ≤10 nm) is a technical problem because of their aggregation tendency. Therefore, the preparation conditions are usually harsh and complex. It is widely recognized that covalent organic frameworks (COFs) represent a novel class of porous crystalline compounds with broad applications in various fields. In this work, an environmentally
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Functional Polyorganosilsesquioxane Nanocomposite Hydrogels With Encapsulated Silver Nanoparticles – Promising Compounds Against Gastrointestinal Pathogen Bacteria ChemistrySelect (IF 2.1) Pub Date : 2024-04-19 D. A. Migulin, J. V. Rozanova, I. B. Meshkov, S. A. Milenin, E. A. Shitikov, A. M. Muzafarov
Nowadays the most common gastrointestinal related gram‐negative H. pylori and E. coli pathogen bacteria that are considered to be the main causes for the development of various gastric diseases and bloodstream infections are rapidly developing resistance against the standard antibiotics, commonly used in the clinical practices. One of the alternative high potential approaches for solving problems of
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One‐Pot Synthesis of Functionalized Carbazoles and β‐Carbolines via Diethyl Azodicarboxylate Mediated Dehydrogenative Aromatization in Deep Eutectic Solvent ChemistrySelect (IF 2.1) Pub Date : 2024-04-19 Thangellapally Shirisha, Subir Majhi, Dhurke Kashinath
Herein we report a one‐pot approach for the functionalized carbazoles and β‐carbolines via Fischer indole/Pictet‐Spengler type reactions followed by diethyl azodicarboxylate (DEAD) mediated dehydrogenative aromatization using Deep Eutectic Solvent (N,N’‐Dimethyl urea and L‐tartaric acid combination) as reaction medium. This one‐pot method enables the synthesis of library of compounds of carbazoles
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One‐Pot Triple and Mixed Double Michael Addition of Activated Alkenes to 2‐Oxindole and 7‐Aza‐2‐Oxindole: Synthesis of C‐3/N‐Functionalized Carbon Rich 2‐Oxindole and 7‐Aza‐2‐Oxindole Derivatives ChemistrySelect (IF 2.1) Pub Date : 2024-04-19 Raman Kavitha Preethi, Sathananthan Kannadasan, Ponnusamy Shanmugam
A simple, efficient, and atom‐economical, one‐pot triple Michael Addition of activated alkenes to 2‐oxindole, 7‐aza‐2‐ indolone, and N‐methyl‐5‐bromo‐7‐aza‐2‐indolone has been developed. Significantly, multifunctionalities have also been achieved via one‐pot mixed Michael addition using the equimolar amount of two different activated alkenes. The reaction provided C‐3 and N‐functionalized carbon‐rich
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Assessing the Impact of π‐Conjugation Length on Aggregation Induced Emission and Self‐Assembly Formation of α‐Cyanostilbene and Bis‐Cyanostilbene ChemistrySelect (IF 2.1) Pub Date : 2024-04-17 Aishwarya P. Waghchoure, Hanuman Narode, Vijay B. Sangale, Zahir Ali Siddiqui, Sanchita Sarkhel, Satish K. Pardeshi, Amit Jaiswal, Nagaiyan Sekar, Sandeep More, Rajesh S. Bhosale
In this work, short π‐conjugated (Z)‐2‐(4‐(2‐cyano‐2‐phenylvinyl)phenoxy)‐N‐(1‐(3‐ethoxy‐4‐methoxyphenyl)‐2‐(methyl sulfonyl)ethyl)acetamide (CYS) and large π‐conjugated 2,2′‐(((1Z,1′Z)‐1,4‐phenylenebis(2‐cyanoethene‐2,1‐diyl))bis(4,1‐phenyl ene))bis(oxy))bis(N‐(1‐(3‐ethoxy‐4‐methoxyphenyl)‐2‐(methyl sulfonyl)ethyl)acetamide (BCYS) compounds were synthesized. Furthermore, the influence of π‐conjugation
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Green Synthesis of Baby Pumpkin Derived Fluorescent Carbon Dots – A Potent Label‐Free Probe for Cd2+ Determination ChemistrySelect (IF 2.1) Pub Date : 2024-04-17 Shihua Liao, Jing Hu, Xiang Long, Shaogui Wu
This study demonstrates a facile solvothermal approach to synthesizing green fluorescent carbon dots (G‐CDs) using baby pumpkin as a natural precursor. The G‐CDs exhibit strong fluorescence emission at 547 nm under excitation at 467 nm, and the highest quantum yield reaching 17.5 % in acetone, making them suitable for a range of applications including sensing, bioimaging, catalysis, and drug delivery
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Green Fluorescent Diamino‐Terephthalonitriles with Reactive Terminal Groups Towards Synthesis of Value‐Added Fluorophores ChemistrySelect (IF 2.1) Pub Date : 2024-04-17 Tanya Raghava, Subhadeep Banerjee
We report synthesis of a library of diamino‐terephthalonitrile based single‐benzene fluorophores (SBFs). These SBFs contain a reactive terminal linker group. They open up the possibility of marrying their excellent fluorescent property with various biogenic units, leading to value‐added SBFs. The solvatofluorochromism behavior of these newly synthesized SBFs was also studied. The emission enhances
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Fabrication of Highly Porous and Sheet Like Fe3O4‐Carbon Nanocomposites: A Versatile Catalyst for Electrocatalytic Oxygen Evolution Reactions ChemistrySelect (IF 2.1) Pub Date : 2024-04-17 S. A. T. Shanmugapriya, Anand Kumar, Mohd Afzal, Ratiram Gomaji Chaudhary, Kotesh Kumar Mandari, Aniruddha Mondal, Sudip Mondal
Fuel cells and metal‐air batteries are examples of renewable energy technologies that depend on having highly effective electrocatalysts for the oxygen evolution reaction (OER). In this study, a mesoporous nanostructure composed of Fe3O4‐Carbon nanocomposites was synthesised using a simple and economically viable approach at a relatively low temperature. The observed catalytic activity of the prepared
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Asymmetric Allylation of Aldoxime Derivatives with β‐Amidoallylboronate in Water and Its Application to Divergent Synthesis of N‐Hydroxy‐γ‐Lactam and 1,2‐Oxazinan‐6‐one ChemistrySelect (IF 2.1) Pub Date : 2024-04-17 Tetsuya Sengoku, Wataru Anze, Naoya Hasegawa, Yuta Mizutani, Asahi Kubota, Toshiyasu Inuzuka, Hidemi Yoda
A new application involving a water–stable amido–functionalized allylboronate has been developed for 1,2‐addition to carbon–nitrogen double bonds. The process achieves highly enantioselective allylation of aldoxime derivatives in water, by employing O‐Boc oximes as substrates under Zn(OH)2–chiral aminophenol catalysis. This process affords the corresponding homoallylic amines with 91–96 % ee. The products
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Preparation and Study of Ti3C2Tx MXene–Deficient In Situ Anchored Fe−Co Alloy Nanoparticle Electrocatalyst for Hydrolysis and Hydrogenolysis ChemistrySelect (IF 2.1) Pub Date : 2024-04-17 Xiancai Zeng, Li Liu, Xianghua Sun, Yue Ma, Wenhao Li, Yan Ma, Keliang Wu, Xiaofei Wang
The novel two–dimensional MXene material Ti3C2Tx has the advantages of a large specific surface area, adjustable band gap, good electrical conductivity, and high stability. However, the precipitation of hydrogen via electrolytic water splitting over Ti3C2Tx has unacceptably slow kinetics. In this paper, Co nanoparticles were incorporated on the Ti3C2TxMXene surface via electrostatic adsorption by utilizing
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Design, Synthesis and In Silico Molecular Docking Evaluation of New Series of 1,2,3‐Triazole Derivatives as Potent Antimicrobial Agents ChemistrySelect (IF 2.1) Pub Date : 2024-04-17 Venkatesan Vellaiyan, Honnappa Nagarajaiah, Adamshafi Shaik, Pilli V. V. N Kishore, Shravan Kumar Gunda
Chalcone and triazole scaffolds have demonstrated a crucial role in the advancement of science and technology. Due to their significance, research has proceeded on the design and development of novel benzooxepine connected to 1,2,3‐triazolyl chalcone structures. The new chalcone derivatives produced by benzooxepine triazole methyl ketone and different aromatic carbonyl compounds. Product structures
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Chitosan‐nTiO2 Nanocomposite Synthesis and its Adsorptive Removal Capacity for Methylene Blue from its Aqueous Solution: Batch Adsorption Study and Modeling ChemistrySelect (IF 2.1) Pub Date : 2024-04-17 Samanwita Bhattacharya, Nirjhar Bar, Baisali Rajbansi, Sudip Kumar Das
The current work used chitosan (CS)‐nTiO2 nanocomposites (CTNCs) prepared with different CS:nTiO2 mass ratios toward the MB dye removal from an aqueous medium in batch method at variable experimental conditions. The stability and competence of the nanocomposites were checked through characterization by SEM, FTIR, XRD, TGA, and BET. The highest removal of MB was 78 % with the adsorbent CS without nTiO2
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Environment Benign Bismuth Based Catalysts for the Expedite Regioselective Ring Opening of Epoxides Under Solvent Free Microwave Condition ChemistrySelect (IF 2.1) Pub Date : 2024-04-17 Deeksha Gupta, Prabal P. Singh
Bismuth‐based catalysts, namely Bi(PO4), (BiO)2CO3, BiF3, and Bi2(C2O4)3, are used as mild and efficient tools for the aminolysis of epoxides under solvent‐free conditions with microwave irradiation, which significantly reduced the reaction time. The catalysts employed are environment friendly, cost‐effective, and demonstrated high efficiency in terms of both high yields and regioselectivity.
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Rapid Synthesis of Phthalonitrile based Push‐Pull Bent Dibenzodioxin and its Utility in Selective Sensing of Ferric Ions ChemistrySelect (IF 2.1) Pub Date : 2024-04-17 Tanya Raghava, Subhadeep Banerjee, Purushothaman Bhavana
A phthalonitrile‐based bent shaped push‐pull dibenzodioxin was synthesized using an efficient and rapid monowave reactor‐assisted protocol in acceptable yields. When aqueous Fe3+ ion solution was added to the bent dibenzodioxin in dimethyl sulfoxide (DMSO), the fluorescence intensity of bent dibenzodioxin at 450 nm was quenched significantly. UV‐visible and fluorimetric measurements displayed high
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Magnetic, Biocompatible and Biodegradable Carboxymethyl Cellulose‐Based Hydrogel for Cationic Dye Adsorption ChemistrySelect (IF 2.1) Pub Date : 2024-04-17 Mehran Kurdtabar, Fatemeh Akhlaghi, Gholam Bagheri Marandi, Mahdi Taghvay Nakhjiri, Mohammad Hasan Zargazi
Ensuring the availability of water resources that are both clean and safe is crucial for the preservation of environmental health and the well‐being of humans. Here, we fabricated carboxymethyl cellulose‐based hydrogel nanocomposite using acrylic acid (AA) and 2‐acrylamido‐2‐methylpropane sulfuric acid (AMPS) monomers and Fe3O4 nanoparticles through a free radical crosslinking process for adsorption
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Biological Activities, DFT and Molecular Docking Studies of Novel Schiff Bases Derived from Sulfamethoxypyridazine ChemistrySelect (IF 2.1) Pub Date : 2024-04-17 Muhammad Wajid, Muhammad Uzair, Gulzar Muhammad, Farhan Siddique, Adnan Ashraf, Sajjad Ahmad, Abdullah F. Alasmari
The present study reported the synthesis and biological activities of sulfamethoxypyridazine (SMPR) Schiff bases (SBs) with different aromatic aldehydes. The antimicrobial potential of SBs against various pathogenic strains (S. epidermidis, E. coli, S. agalactiae, S. aureus, S. typhi, K. pneumoniae, C. albicans, and C. tropicalis) was explored by disc diffusion method. The antidiabetic potential was
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New 2H‐Chromene‐Based Hydrazone Derivatives as Promising Anti‐Breast Cancer Agents: Efficient Synthesis, Spectral Characterization, Molecular Docking, and ADMET Studies ChemistrySelect (IF 2.1) Pub Date : 2024-04-17 Bhabani Shankar Panda, Barsha Samanta, S. S. S. S. Sudha Ambadipudi, Sabita Nayak, V. Lakshma Nayak, Sistla Ramakrishna, Seetaram Mohapatra, Pabitra Mohan Behera, Luna Samanta
A new series of 2H‐chromene‐based hydrazones (10 a–w, 12 a–d, and 14 a–d) were efficiently synthesized by the reaction of substituted 2H‐chromene aldehydes (8 a–w) with various hydrazines (9, 11, and 13) in absolute ethanol under microwave irradiation as well as by lemon juice mediated conventional heating. The structures of synthesized target molecules were identified by spectroscopic analysis methods
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One–Pot Three–Component Synthesis of 2,4,5–Triaryl Imidazoles using Fe3O4@BisImid−CuBr Nanocomposite as an Ecofriendly and Efficient Magnetically Reusable Catalyst ChemistrySelect (IF 2.1) Pub Date : 2024-04-17 F. Al‐Dolaimy, Ali H. Alsalamy, Hussein Abdullah Abbas, Fadhil A. Rasen, Zaid Abdulhussein, Montather F. Ramadan, Ahmed Hussien R. Abbas, Hesham S. Mustafa
Imidazoles are one of the keys of N‐heterocycle molecules that exist in the structure of many biomolecules. In this research project, we reported that Fe3O4@BisImid−CuBr nanocomposite is an attractive and efficient nanomagnetic catalyst to afford 2,4,5–triaryl imidazoles through reactions of 1,2–diketones and aldehydes in the presence of NH4OAc under ecofriendly conditions. The Fe3O4@BisImid−CuBr nanocomposite
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Discovery of Small‐Molecules as Potential GSK‐3β Inhibitors for the Treatment of Alzheimer's Disease Using Pharmacophore‐Based Virtual Screening ChemistrySelect (IF 2.1) Pub Date : 2024-04-17 Kailash Jangid, Bharti Devi, Pooja Rani, Naveen Kumar, Vinay Kumar, Vinod Kumar
Glycogen synthase kinase‐3β (GSK‐3β) plays pivotal role in regulating diverse range of cellular functions. It plays negative role in cellular signaling pathways and believed to involved in the pathologies of various diseases like neurological disorders, type II diabetes, inflammation, cardiac hypertrophy, cancer and bipolar disorders. GSK‐3β is proposed as a promising target for drug discovery in treating
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Unraveling the Impact of Pesticide Exposure on Apis Honey Bees: An Investigation on Succinate Dehydrogenase Subunit A (SDHA) Inhibition Mechanisms ChemistrySelect (IF 2.1) Pub Date : 2024-04-17 Ramkumar Haran, Chakkarai Sathyaseelan, Ettiappan Sumathi, Mannu Jayakanthan, Settu Vijay, Ganeshan Shandeep, Vangili Ramasami Saminathan, Madapuji Rajagopalan Srinivasan, Eswaran Kokiladevi
Concerns about pollinator health and the influence on agricultural ecosystems have developed as a result of pesticide‐caused population declines in honey bees. The research looked at the properties of the SDHA subunit of the enzyme Succinate dehydrogenase, which is important for energy production and mitochondrial function. The goal was to investigate the structural and functional characteristics of
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Effects of the Solvent and the Nucleophile on the Photochemical Synthesis of Azepines ChemistrySelect (IF 2.1) Pub Date : 2024-04-17 Marina A. Giricheva, Andrei V. Budruev
The research focused on the photolysis of ortho‐ and para‐substituted aryl azides and the preparation of 2‐arylamino‐substituted azepines. The best results were achieved in 1,4‐dioxane for ortho‐substituted azides and in ethanol for para‐substituted azides, respectively. It was found that reactions with arylamines, which have electron‐donating groups, typically produce higher yields of heterocycles
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[CMMIM][BF4] as a Sustainable Catalyst for Spirooxindoles Synthesis via One‐Pot Multicomponent Reaction: Insights into their Photophysical Properties and Theoretical Calculations ChemistrySelect (IF 2.1) Pub Date : 2024-04-17 Venkatesan Kali, Barnali Maiti
This study shows an effective approach for the synthesis of spirooxindole‐pyrans and bis‐spirooxindole‐pyrans derivatives using 5 mol % of [CMMIM][BF4] ionic liquid. The synthesis of a library of 28 derivatives was accomplished with impressive yields, ranging from 81 % to 97 %. The derivatives were successfully characterized by 1H‐NMR, 13C‐NMR, FT‐IR, and high‐resolution mass spectral techniques. In
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Universal Dielectric Response in Electronically Correlated Functional Oxides CaCu3Ti4O12, LaFeO3, YFe0.5Cr0.5O3 and their Nanocomposites: A Comparative Study ChemistrySelect (IF 2.1) Pub Date : 2024-04-17 Sudipa Bhattacharya, Preeti Yadav, Manoj K. Singh, M. Vasundhara, Arup Gayen, Asish K. Kundu, Md. Motin Seikh
CaCu3Ti4O12 (CCTO), LaFeO3 (LFO) and YFe0.5Cr0.5O3 (YFCO) were synthesized via conventional sol–gel auto–combustion method using citric acid as gelling agent. The X‐ray diffraction analysis revealed the phase purity of the samples. The energy dispersive X‐ray (EDX) analysis confirms the stoichiometry of the pristine phases. The average particle size obtained from the field emission Scanning electron
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Synthesis and Anticancer Evaluation of Benzylated Indole Based Alkyl‐Substituted Pyrido[2,3‐d]Pyrimidines Targeting Thymidylate Synthase ChemistrySelect (IF 2.1) Pub Date : 2024-04-17 Adarsh Kumar, Ankit Kumar Singh, Harshwardhan Singh, Balasubramanian Narasimhan, Pradeep Kumar
Colorectal cancer (CRC) is the second most common cause of cancer‐related deaths and the third most common cancer worldwide. Because of its importance in DNA biosynthesis, thymidylate synthase (TS) has gathered attention as a promising target for cancer therapy. Herein, we have designed and synthesized 12 novel 5‐(N‐Benzyl indol‐3‐yl) pyrido[2, 3‐d] pyrimidine based derivatives and assessed their anticancer
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The Co‐UMO‐1 Metal Organic Framework: Solvothermal Synthesis of [Co3{μ3‐O}2(C14H8O6S)2(H2O)3(C2H5OH)] ⋅ 2H2O, Characterizations, and Application in Methylene Blue Removal ChemistrySelect (IF 2.1) Pub Date : 2024-04-17 Manel Mansour, Mouhieddinne Guergueb, Nadhem Missaoui, Celia Castillo, Enrique Guitierrez Puebla, Brahim Ayed, Houcine Barhoumi, Umit B. Demirci, Hamza Kahri
The new Co‐based MOF (also called Co‐UMO‐1 MOF with structure of [Co3{μ3‐O}2(C14H8O6S)2(H2O)3(C2H5OH)] ⋅ 2H2O) is solvothermally synthesized in a mixture of water and ethanol at 170 °C for 3 days. The as‐recovered pink‐colored stick‐like crystals crystallizes in the monoclinic crystal system P21/c (n° 13), which consists of three crystallographically independent Co(II) elements that adopt the octahedral
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Reduction of Methylene Blue Using Silica Nanoparticles Obtained from Waste ZrC ChemistrySelect (IF 2.1) Pub Date : 2024-04-17 Fatemeh Abadian‐Naeini, Mohsen Mohsennia, Mojtaba Bagherzadeh
The study conducted an extraction of pure amorphous nano‐silica (SiO2 NP) from waste product at the ZrC factory. Various techniques such as TEM, SEM‐EDX, ICP, XRD, FTIR, BET, and DLS were utilized to synthesize and characterize the silica nanoparticle. The results showed successful production of pure amorphous silica, with no discernible difference in purity percentage between samples prepared with
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Fabrication of Catechol Sensitized Hollow Microspheres ZnTiO3/TiO2/ZnO for the Photodegradation of Methylene Blue ChemistrySelect (IF 2.1) Pub Date : 2024-04-17 Yan Yu, Wei Ma, Chun Li, Liangliang Chang, Shan Xu, Binghua Yao, Baoyue Cao, Pei Zhao, Fangyuan Tian
Designing new materials that can be used to treat environmental pollutants is one of the prime focuses of chemical science. Here, an unprecedented photocatalytic material with high activity of catechol sensitized ZnTiO3/TiO2/ZnO hollow microspheres was synthesized by hydrothermal method. The structure and properties of the composite photocatalyst were analyzed by various testing methods. The photocatalytic
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Photocatalytic Degradation of Maxilon Dye Pollutants using Nano‐Architecture Functional Materials: A Review ChemistrySelect (IF 2.1) Pub Date : 2024-04-17 Stephen Sunday Emmanuel, Ademidun Adeola Adesibikan, Christopher Olusola Olawoyin, Mustapha Omenesa Idris
The most essential task in the twenty‐first century is to fight the alarming growing pollution in the aquatic body in which effluent of one of the most colouring dye categories called maxilon dye is a major contributor. This review thus specifically focuses on the use of nanoparticles (NPs) for photocatalytic degradation of maxilon dye contaminants in water bodies. The work empirically presented the
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Anti‐Coronavirus Activity of Certain Herbacetin Derivatives, A Theoretical Study ChemistrySelect (IF 2.1) Pub Date : 2024-04-17 Marjan A. Rafiee
Flavonoids are natural products commonly found in the human diet with anti‐viral activity. The electrochemical activity of flavonoids is effective in their inhibitory properties. Herbacetin is an anti‐coronavirus drug from the flavonoid family. To understand structure‐electrochemical activity relations, ab initio calculations on some selected herbacetin derivatives were carried out using Gaussian 09
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Temperature/GSH Dual Responsive Fluorinated Mesoporous Silica‐Coated Au NRs for Serum‐Resistant Gene Delivery** ChemistrySelect (IF 2.1) Pub Date : 2024-04-17 Weitao Sun, Chunhua Fu, Zhongyu Zhang, Wan Sun
Mesoporous silica nanoparticles (MSN) are emerging as one of the most appealing candidates for gene carriers. Nevertheless, one major obstacle for their clinical application is the lack of efficient controlled release and gene delivery. In this study, a mesoporous silica‐modified gold nanorods (Au NRs) controlled release platform was synthesized. Then a thermosensitive copolymer was grafted to the
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Adsorption of Coomassie Brilliant Blue on a Novel Eco‐Friendly Nanogel from Simulated Water: Equilibrium, Kinetic, and Thermodynamic Studies ChemistrySelect (IF 2.1) Pub Date : 2024-04-17 Suhail Ayoub Khan, Ankita Manchanda, Tabrez Alam Khan
Herein a novel gum acacia‐alginate nanogel (GAA) was synthesized via ultrasound‐assisted crosslinking by DPPH and applied for the removal of coomassie brilliant blue (CBB) dye. The fabrication of GAA and its interaction with CBB was specified via FTIR, XRD, SEM, and TEM techniques. The process parameters at which maximum adsorption efficiency, qe (80.12 mg/g), and % efficiency >94 % were achieved include
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Visible‐Light Photochromism of Polyoxometallate H4PMo11VO40 Composite Film Based on Polyvinylpyrrolidone with a Fast Response ChemistrySelect (IF 2.1) Pub Date : 2024-04-17 Zijing Wang, Limei Ai, Minghui Liu, Zeqing Wang
The visible‐light photochromic composite films with a fast response were prepared by entrapping H4PMo11VO40 into polyvinylpyrrolidone (PVP) networks. PMo11V/PVP composite films’ structure and morphology were characterized by IR spectroscopy, XRD and TEM. The skeleton structure of PMo11V and PVP were still remained through IR spectroscopy analysis. The photochromism performance of PMo11V/PVP composite
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Reusable Underwater Superoleophobic Polyacrylamide Membranes for Effective Oil‐Water Separation and Dye Removal ChemistrySelect (IF 2.1) Pub Date : 2024-04-17 Arpita Padhan, Vickramjeet Singh
Water contamination by oily wastes continues to rise with industrialization and pose a threat to marine ecosystem and public health. Water repellent special wettability membranes have been fabricated for oil removal. These superhydrophobic membranes have been fabricated utilizing hazardous chemicals such as fluorinated compounds, which again have shown toxicity. In contrast, environmentally friendly