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Effects and mechanisms of N6-methyladenosine RNA methylation in environmental pollutant-induced carcinogenesis Ecotox. Environ. Saf. (IF 6.8) Pub Date : 2024-04-25 Tong-fei Li, Zhijie Xu, Kui Zhang, Xiaoxin Yang, Abhimanyu Thakur, Shuangshuang Zeng, Yuanliang Yan, Wangrui Liu, Ming Gao
Environmental pollution, including air pollution, plastic contamination, and heavy metal exposure, is a pressing global issue. This crisis contributes significantly to pollution-related diseases and is a critical risk factor for chronic health conditions, including cancer. Mounting evidence underscores the pivotal role of N6-methyladenosine (mA) as a crucial regulatory mechanism in pathological processes
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Lipid responses to perfluorooctane sulfonate exposure for multiple rat organs Ecotox. Environ. Saf. (IF 6.8) Pub Date : 2024-04-25 Tzu-Hsin Yen, Sheng-Han Lee, Chuan-Ho Tang, Hao-Jan Liang, Ching-Yu Lin
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Aflatoxin B1-exposed hepatocyte-derived extracellular vesicles: Initiating hepatic stellate cell-mediated liver fibrosis through a p53-Parkin-dependent mitophagy pathway Ecotox. Environ. Saf. (IF 6.8) Pub Date : 2024-04-25 Lei Yang, Yun-Lu Gao, Shan Jiang, Bo Qian, Lin Che, Jia-Shen Wu, Ze-Bang Du, Ming-Zhu Wang, Yun Yang, Yu-Chun Lin, Gang Liu, Zhong-Ning Lin
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Transcriptomic and physiological analyses of Symphytum officinale L. in response to multiple heavy metal stress Ecotox. Environ. Saf. (IF 6.8) Pub Date : 2024-04-25 Yi-fan Xu, Da-wei Chen, Jing Ma, Ruo-chun Gao, Jie Bai, Qin-zheng Hou
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Modeling temperature-dependent life-cycle toxicity of thiamethoxam in Chironomus riparius using a DEB-TKTD model Ecotox. Environ. Saf. (IF 6.8) Pub Date : 2024-04-25 Josef Koch, Silke Classen, Daniel Gerth, Natalie Dallmann, Tido Strauss, Maxime Vaugeois, Nika Galic
The neonicotinoid insecticide thiamethoxam (TMX) is widely used to protect crops against insect pests. Despite some desirable properties such as its low toxicity to birds and mammals, concerns have been raised about its toxicity to non-target arthropods, including freshwater insects like chironomids. Whereas multiple studies have investigated chronic effects of neonicotinoids in chironomid larvae at
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Effects of crosstalk between steroid hormones mediated thyroid hormone in zebrafish exposed to 4-tert-octylphenol: Estrogenic and anti-androgenic effects Ecotox. Environ. Saf. (IF 6.8) Pub Date : 2024-04-25 Jangjae Lee, Seonggeun Zee, Hugh I. Kim, Sung-Hee Cho, Chang-Beom Park
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Polyethylene, whose surface has been modified by UV irradiation, induces cytotoxicity: A comparison with microplastics found in beaches Ecotox. Environ. Saf. (IF 6.8) Pub Date : 2024-04-25 Yudai Ikuno, Hirofumi Tsujino, Yuya Haga, Sota Manabe, Wakaba Idehara, Mii Hokaku, Haruyasu Asahara, Kazuma Higashisaka, Yasuo Tsutsumi
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Environmental antibiotics exposure and childhood obesity: A cross-sectional case-control study Ecotox. Environ. Saf. (IF 6.8) Pub Date : 2024-04-25 Yu-Qing Wang, Yu Zhang, Wei-Feng Tang, Zhong-Cheng Luo, Yun-Ting Zhang, Chong-huai Yan, Jun Zhang, Qian Chen
Children’s exposures to environmental antibiotics are a major public health concern. However, limited data are available on the effects of environmental antibiotic exposures on childhood obesity. Our study aimed to explore this relationship. We conducted a cross-sectional case-control study nested in a population-based survey of primary school students, including 1855 obese and 1875 random selected
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Effect of MEHP on testosterone synthesis via Sirt1/Foxo1/Rab7 signaling pathway inhibition of lipophagy in TM3 cells Ecotox. Environ. Saf. (IF 6.8) Pub Date : 2024-04-24 Yu Hao, Xuan'en Tian, Fengmei Yan, Xiuqin Wang, Jing Huang, Ling Li
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Chlorpyrifos degradation and its impacts on phosphorus bioavailability in microplastic-contaminated soil Ecotox. Environ. Saf. (IF 6.8) Pub Date : 2024-04-24 Lingling Ding, Yan Wang, Hui Ju, Darrell W.S. Tang, Sha Xue, Violette Geissen, Xiaomei Yang
Pesticide residues and microplastics (MPs) in agricultural soils are two major concerns for soil health and food safety. The degradation of chlorpyrifos (CPF), an organophosphorus pesticide, releases phosphates. This process may be affected by the presence of MPs in the soil. The combination of CPF and MPs presence in the soil may thus produce interaction effects that alter the soil phosphorus (P)
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Gut bacterium Burkholderia cepacia (BsNLG8) and immune gene Defensin A contribute to the resistance against Nicotine-induced stress in Nilaparvata lugens (Stål) Ecotox. Environ. Saf. (IF 6.8) Pub Date : 2024-04-24 Xuemei Wang, Junaid Zafar, Xiaotong Yang, Surajit De Mandal, Yingying Hong, Fengliang Jin, Xiaoxia Xu
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Effect of total dissolved gas supersaturation on the passage behavior of silver carp (Hypophthalmichthys molitrix) and ya-fish (Schizothorax prenanti) through an experimental vertical slot fishway Ecotox. Environ. Saf. (IF 6.8) Pub Date : 2024-04-24 Xin Yang, Haoran Shi, Xiaoqing Liu, Yadong Ou, Xincong Liu, Minne Li, Quan Yuan
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Dihalogenated nitrophenols exposure induces developmental neurotoxicity in zebrafish embryo Ecotox. Environ. Saf. (IF 6.8) Pub Date : 2024-04-24 Wenting Zhu, Yingying Liu, Xiongzhi Xuan, Zeqiong Xu, Peng Gao, Zhigang Jin, Huachang Hong, Hongjie Sun
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Dynamic transcriptome profiling revealed a key gene ZmJMJ20 and pathways associated with cadmium stress in maize Ecotox. Environ. Saf. (IF 6.8) Pub Date : 2024-04-24 Shuai Yu, Jialun Zhu, Yanzhe Yin, Xiaoyu Zhang, Yuxin Dai, Yupeng Xing, Xipeng Cheng, Ao Zhang, Cong Li, Yanshu Zhu, Yanye Ruan, Xiaomei Dong, Jinjuan Fan
Cadmium (Cd) pollution in soil poses a global concern due to its serious impacts on human health and ecological security. In plants, tremendous efforts have been made to identify some key genes and pathways in Cd stress responses. However, studies on the roles of epigenetic factors in response to Cd stress were still limited. In the study, we first gain insight into the gene expression dynamics for
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The potential mechanism of iron overload-induced colonic inflammation Ecotox. Environ. Saf. (IF 6.8) Pub Date : 2024-04-24 Shaopeng Sun, Bin Lv
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Biological effects of vanillic acid, iso-vanillic acid, and orto-vanillic acid as environmental pollutants Ecotox. Environ. Saf. (IF 6.8) Pub Date : 2024-04-24 Marzena Matejczyk, Piotr Ofman, Edyta Juszczuk-Kubiak, Renata Świsłocka, Wong Ling Shing, Kavindra Kumar Kesari, Balu Prakash, Włodzimierz Lewandowski
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Synergistic suppression of BDNF via epigenetic mechanism deteriorating learning and memory impairment caused by Mn and Pb co-exposure Ecotox. Environ. Saf. (IF 6.8) Pub Date : 2024-04-24 Lancheng Wei, Hongjian He, Shuting Yang, Qianqian Shi, Xinhang Wang, Liyuan Huang, Jianyong Lu, Yinghui Shen, Kaikai Zhi, Junni Xiang, Chengying Chen, Jiao Mo, Zhijian Zheng, Yunfeng Zou, Xiaobo Yang, Shen Tang, Xiyi Li, Cailing Lu
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Polystyrene exposure induces lamb gastrointestinal injury, digestive disorders and inflammation, decreasing daily gain, and meat quality Ecotox. Environ. Saf. (IF 6.8) Pub Date : 2024-04-23 Xiao Chang, Yan Li, Yujie Han, Yi Fang, Hai Xiang, Zijiao Zhao, Bao Zhao, Rongzhen Zhong
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PM2.5 exposure upregulates pro-inflammatory protein expression in human microglial cells via oxidant stress and TLR4/NF-κB pathway Ecotox. Environ. Saf. (IF 6.8) Pub Date : 2024-04-23 Ling Zhang, Fei Xu, Yishu Yang, Lin Yang, Qiong Wu, Han Sun, Zhen An, Juan Li, Hui Wu, Jie Song, Weidong Wu
Exposure to ambient PM is associated with neurodegenerative disorders, in which microglia activation plays a critical role. Thus far, the underlying mechanisms for PM-induced microglia activation have not been well elucidated. In this study, a human microglial cell line (HMC3) was used as the model to examine the inflammatory effect (hall marker of microglia activation) of PM and regulatory pathways
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Cadmium/zinc stresses and plant cultivation influenced soil microflora: a pot experiment conducted in field Ecotox. Environ. Saf. (IF 6.8) Pub Date : 2024-04-23 Di Guo, Kunkun Tian, Xinyue Peng, Shihao Liu, Xixia Xu, Wenwen Tian
It’s of great challenge to address for heavy metal-contaminated soil. Once the farmland is contaminated with heavy metals, the microbial ecology of the plant rhizosphere will change, which in turn impacts crop productivity and quality. However, few studies have explored the effects of heavy metals on plant rhizosphere microbes in farmland and the role that plant cultivation plays in such a phytoremediation
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Novel insights into antimony mobilization in different high- antimony aquifers from the molecular signatures of dissolved organic matter Ecotox. Environ. Saf. (IF 6.8) Pub Date : 2024-04-23 Chunming Hao, Qianqian Sun, Ximeng Sun, Qiong Li
The crucial role of the fluorescent components of dissolved organic matter (DOM) in controlling antimony (Sb) mobilization in groundwater has been confirmed. However, the molecular signatures contributing to Sb enrichment in DOM remain unknown. This study aims to investigate the origins and molecular compositions of DOM in different high-Sb aquifers (Sb-mining and no-Sb-mining aquifer), as well as
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Effect of magnetized water irrigation on Cd subcellular allocation and chemical forms in leaves of Festuca arundinacea during phytoremediation Ecotox. Environ. Saf. (IF 6.8) Pub Date : 2024-04-23 Jie Luo, Siyao Feng, Mingpo Li, Yue He, Yuping Deng, Min Cao
The application of an external magnetic field has been shown to improve the Cd phytoremediation efficiency of by leaf harvesting. However, the influencing mechanisms of the promoting effect have not yet been revealed. This study evaluated variations in the Cd subcellular allocation and fractions in various leaves, with or without magnetized water irrigation. Over 50 % of the metal were sequestered
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The antagonism mechanism of astilbin against cadmium-induced injury in chicken lungs via Treg/Th1 balance signaling pathway Ecotox. Environ. Saf. (IF 6.8) Pub Date : 2024-04-23 Guangliang Shi, Tiange Tai, Yusong Miao, Liangchun Yan, Tianyu Han, Han Dong, Zhaoyang Liu, Tingting Cheng, Yiding Liu, Yu Yang, Shanshan Fei, Bo Pang, Tiezhu Chen
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Curcumin alleviates zearalenone-induced liver injury in mice by scavenging reactive oxygen species and inhibiting mitochondrial apoptosis pathway Ecotox. Environ. Saf. (IF 6.8) Pub Date : 2024-04-23 Xiaopeng Yang, Hao Zheng, Junlong Niu, Xiaoshuang Chen, Hongfei Li, Zhiyong Rao, Yongpeng Guo, Wei Zhang, Zhixiang Wang
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Fates and models for exposure pathways of pyrethroid pesticide residues: A review Ecotox. Environ. Saf. (IF 6.8) Pub Date : 2024-04-23 Shan Liu, Jisha Yan, Bowen Xu, Xinyi Huang, Haixiong Qin, Jiayuan Zhao, Chen Xia, Shen Yan, Gang Liu
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The characteristics of fungal responses to uranium mining activities and analysis of their tolerance to uranium Ecotox. Environ. Saf. (IF 6.8) Pub Date : 2024-04-23 Lu Qiu, Ajia Sha, Na Li, Yanqiong Ran, Peng Xiang, Lin Zhou, Ting Zhang, Qian Wu, Liang Zou, Zhaoqiong Chen, Qiang Li, Changsong Zhao
The influence of uranium (U) mining on the fungal diversity (FD) and communities (FC) structure was investigated in this work. Our results revealed that soil FC richness and FD indicators obviously decreased due to U, such as Chao1, observed OTUs and Shannon index (<0.05). Moreover, the abundances of , , and were notably reduced in soil samples owing to U mining activities (<0.05). In contrast, the
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Study on the role of CCM3 gene and lead exposure induced neurotoxicity through neurovascular units Ecotox. Environ. Saf. (IF 6.8) Pub Date : 2024-04-23 Yumeng Li, Yun Liu, Kangkang Liu, Tao Tao, Liuxue Yang, Ruxi Liu, Hang Zhou, Dan Liang, Ying Zhang, Danni Huang, Yi Sun
This study aimed to determine the toxic effects of vascular gene deficiency and lead (Pb) exposure on the nervous system. Lentiviral transfection was performed to generate a stable strain of brain microvascular endothelial cells with low expression. MTT assay assessed the survival rate of cells exposed to Pb, determining the dose and duration of Pb exposure . Proteomic analysis was performed on the
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Removal and reduction mechanism of Cr (VI) in Leersia hexandra Swartz constructed wetland-microbial fuel cell coupling system Ecotox. Environ. Saf. (IF 6.8) Pub Date : 2024-04-22 Yucui Shi, Qing Liu, Guowei Wu, Shasha Zhao, Yongwei Li, Shaohong You, Guofu Huang
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The mitochondria-targeted antioxidant MitoQ ameliorates inorganic arsenic-induced DCs/Th1/Th2/Th17/Treg differentiation partially by activating PINK1-mediated mitophagy in murine liver Ecotox. Environ. Saf. (IF 6.8) Pub Date : 2024-04-22 Hui Li, Yaning Guo, Wei Su, Huan Zhang, Xiaoxi Wei, Xinyu Ma, Shuwen Gong, Gaoyang Qu, Lin Zhang, Hong Xu, Fuhai Shen, Shoufang Jiang, Dingjie Xu, Jinlong Li
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Associations of dichlorophenols, trichlorophenols, and ortho-phenylphenol with the risk and prognosis of diabetes and prediabetes: A population-based study Ecotox. Environ. Saf. (IF 6.8) Pub Date : 2024-04-22 Jiayin Ou, Ronghui Xian, Jiayu Li, Jianhe Zhao, Kaiyao Zhang, Peishan Mo, Jiansong Fang, Yue Shen, Xiaoling Hu, Shuhuan Fang, Wei Liu, Huafeng Pan
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Genome-wide DNA methylation changes in Oryzias melastigma embryos exposed to the water accommodated fraction of crude oil Ecotox. Environ. Saf. (IF 6.8) Pub Date : 2024-04-22 Chenshi Wang, Wei Lei, Lichao Du, Yiran Xu, Yingbin Lou, Mo Peng, Dongxu Gao
The water accommodated fraction (WAF) of crude oil exerts considerable impacts on marine fish during embryonic stage. Clarifying changes in epigenetic modifications is helpful for understanding the molecular mechanism underlying the toxicity of embryonic WAF exposure. The aim of this study was to explore genome-wide DNA methylation changes in embryos after exposure to the nominal total petroleum hydrocarbon
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Effect of zeolites on the reduction of the ecotoxicity of carbamazepine in the environment Ecotox. Environ. Saf. (IF 6.8) Pub Date : 2024-04-22 Aleksandra Bogusz, Beata Tomczyk, Magdalena Trzcińska, Barbara Mirosław, Barbara Gworek
In this study, the impact of calcination of zeolites on the ecotoxicity of carbamazepine solutions in two matrices, water and synthetic sewage, was assessed. Two types of zeolites were tested: natural zeolite, in the form of a zeolite rock consisting mainly of clinoptilolite, and a synthetic zeolite type 5 A. Additionally, zeolites were calcined at a temperature of 200 °C. The kinetics of carbamazepine
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Exposure to nicotine regulates prostaglandin E2 secretion and autophagy of granulosa cells to retard follicular maturation in mammals Ecotox. Environ. Saf. (IF 6.8) Pub Date : 2024-04-22 Xiaofeng Zhou, Yingting He, Hongyan Quan, Jinghao Yang, Shuo Li, Yao Jiang, Jiaqi Li, Xiaolong Yuan
Exposure to nicotine by cigarette smoking have shown strongly defectives on the physiological function of ovaries, which in turn leads to disorders of fertility in women. However, the potential molecular mechanisms remain to be elucidated. In this study, we notably found that nicotine was likely to specifically raise the expression of histone deacetylase 3 () to promote the apoptosis and autophagy
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Tracing toxic path of antimony: From bioaccumulation to DNA hypomethylation in zebrafish (Danio rerio) Ecotox. Environ. Saf. (IF 6.8) Pub Date : 2024-04-22 Jingyun Zhang, Aijiang Yang, Wen Cui, Jian Zhang, Apin Niu, Xia Hu, Qing Li
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Environmental pollutants and male infertility: Effects on CatSper Ecotox. Environ. Saf. (IF 6.8) Pub Date : 2024-04-22 Yuxin He, Binhui Wang, Jian Huang, Dalei Zhang, Yangyang Yuan
Infertility is a growing health concern among many couples worldwide. Men account for half of infertility cases. CatSper, a sperm-specific Ca channel, is expressed on the cell membrane of mammalian sperm. CatSper plays an important role in male fertility because it facilitates the entry of Ca necessary for the rapid change in sperm motility, thereby allowing it to navigate the hurdles of the female
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Public health assessment of Kenyan ASGM communities using multi-element biomonitoring, dietary and environmental evaluation Ecotox. Environ. Saf. (IF 6.8) Pub Date : 2024-04-22 Maureene Auma Ondayo, Michael J. Watts, Olivier S. Humphrey, Odipo Osano
The Kakamega gold belt's natural geological enrichment and artisanal and small-scale gold mining (ASGM) have resulted in food and environmental pollution, human exposure, and subsequent risks to health. This study aimed to characterise exposure pathways and risks among ASGM communities. Human hair, nails, urine, water, and staple food crops were collected and analysed from 144 ASGM miners and 25 people
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Vital role of oxidative stress in tadpole liver damage caused by polystyrene nanoparticles Ecotox. Environ. Saf. (IF 6.8) Pub Date : 2024-04-19 Hao Zang, Cenxi Zhao, Runqiu Cai, Haiyan Wu, Liutao Wei, Chaoyu Zhou, Jie Chai, Xuepeng Teng, Tianlong Liu
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HO-1 upregulation promotes mitophagy-dependent ferroptosis in PM2.5-exposed hippocampal neurons Ecotox. Environ. Saf. (IF 6.8) Pub Date : 2024-04-19 Xiaolan Li, Qin Ran, Xiang He, Dan Peng, Anying Xiong, Manling Jiang, Lei Zhang, Junyi Wang, Lingling Bai, Shengbin Liu, Shiyue Li, Baoqing Sun, Guoping Li
Fine particulate matter (PM2.5) has been extensively implicated in the pathogenesis of neurodevelopmental disorders, but the underlying mechanism remains unclear. Recent studies have revealed that PM2.5 plays a role in regulating iron metabolism and redox homeostasis in the brain, which is closely associated with ferroptosis. In this study, the role and underlying mechanism of ferroptosis in PM2.5-induced
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Toxic mechanism in Daphnia magna due to phthalic acid esters and CuO nanoparticles co-exposure: The insight of physiological, microbiomic and metabolomic profiles Ecotox. Environ. Saf. (IF 6.8) Pub Date : 2024-04-18 Xu Jin, Junlan Pan, Cheng Zhang, Xuesong Cao, Chuanxi Wang, Le Yue, Xiaona Li, Yinglin Liu, Zhenyu Wang
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Cadmium modulates intestinal Wnt/β-catenin signaling ensuing intestinal barrier disruption and systemic inflammation Ecotox. Environ. Saf. (IF 6.8) Pub Date : 2024-04-18 Muskan Verma, Manika Garg, Aiysha Siddiq Khan, Pawan Yadav, Saman Saim Rahman, Asghar Ali, Mohan Kamthan
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Integrated physiological, intestinal microbiota, and metabolomic responses of adult zebrafish (Danio rerio) to subacute exposure to antimony at environmentally relevant concentrations Ecotox. Environ. Saf. (IF 6.8) Pub Date : 2024-04-18 Can Liu, Dongmei Huang, Xiangquan Sheng, Jianzhong Zhu, Si Dong, Song Chen, Yaying Wang, Ao Tang, Renyan Duan, Zeliang Yang, Jing Bai, Yu Zheng
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Identifying piRNAs that regulate BaP-induced lung injuries: A bottom-up approach from toxicity pathway investigation to animal validation Ecotox. Environ. Saf. (IF 6.8) Pub Date : 2024-04-18 Qinkai Lei, Chenlong Du, Yumei Ma, Yingqing Shou, Li Chen, Chiyuan Feng, Yuxin Zheng, Dianke Yu, Yuan Jin
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Salvia miltiorrhiza polysaccharide mitigates AFB1-induced liver injury in rabbits Ecotox. Environ. Saf. (IF 6.8) Pub Date : 2024-04-17 Lu Zhang, Ying Liu, Qiongyi Zhang, Weiyu Yao, Zenghui Zhao, Xiao Wang, Yongzhan Bao, Wanyu Shi
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The use of amino acids and their derivates to mitigate against pesticide-induced toxicity Ecotox. Environ. Saf. (IF 6.8) Pub Date : 2024-04-17 Guo-ping Zhao, Wei-long Cheng, Zhi-hui Zhang, Yi-xuan Li, Ying-qiu Li, Fang-wei Yang, Yan-bo Wang
Exposure to pesticides induces oxidative stress and deleterious effects on various tissues in non-target organisms. Numerous models investigating pesticide exposure have demonstrated metabolic disturbances such as imbalances in amino acid levels within the organism. One potentially effective strategy to mitigate pesticide toxicity involves dietary intervention by supplementing exogenous amino acids
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Maternal exposure to ambient ozone and fetal conotruncal heart defects in China: A multicenter cohort study Ecotox. Environ. Saf. (IF 6.8) Pub Date : 2024-04-17 Yanping Ruan, Yaqi Wang, Jianhui Guo, Tingting Man, Xiaoyan Hao, Xiaoxue Zhou, Chenyu Wang, Hanyu Deng, Jing Li, Zhiyong Zou, Yihua He
The relationships between maternal genetic and environmental exposure and conotruncal heart defects (CTDs) have been extensively investigated. Nevertheless, there is limited knowledge regarding the impact of ozone (O) on the risk of CTDs. To explore the correlation between maternal exposure to O and CTDs in China. Pregnant women who underwent fetal echocardiography at Beijing Anzhen Hospital between
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Detoxification of tetracycline and synthetic dyes by a newly characterized Lentinula edodes laccase, and safety assessment using proteomic analysis Ecotox. Environ. Saf. (IF 6.8) Pub Date : 2024-04-17 Shuxue Zhao, Xiaohang Li, Xingdong Yao, Xuyang Liu, Chao Pan, Lizhong Guo, Jie Bai, Tiantian Chen, Hao Yu, Chunhui Hu
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miR-584–5p / Ykt6 - mediated autophagy - lysosome - exosome pathway as a critical route affecting the toxic effects of lead on HK-2 cells Ecotox. Environ. Saf. (IF 6.8) Pub Date : 2024-04-17 Yiren Xiong, Zuqing Hu, Di Ouyang, Meilin Tang, Jiayi He, Shanshan He, Renyi Liu, Zhenjie Gao, Ying Chen, Dalin Hu
Lead is a widespread environmental pollutant with serious adverse effects on human health, but the mechanism underlying its toxicity remains elusive. This study aimed to investigate the role of miR-584–5p / Ykt6 axis in the toxic effect of lead on HK-2 cells and the related mechanism. Our data suggested that lead exposure caused significant cytotoxicity, DNA and chromosome damage to HK-2 cells. Mechanistically
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MSC-derived exosomes mitigate cadmium-induced male reproductive injury by ameliorating DNA damage and autophagic flux Ecotox. Environ. Saf. (IF 6.8) Pub Date : 2024-04-16 Zhihong Chen, Jiahui Mo, Qiyun Yang, Zexin Guo, Xinyu Li, Dongmei Xie, Chunhua Deng
Cadmium, an environmental toxicant, severely impairs male reproductive functions and currently lacks effective clinical treatments. Mesenchymal stem cell-derived exosomes (MSC-Exos) are increasingly recognized as a potential alternative to whole-cell therapy for tissue injury and regeneration. This study aims to investigate the protective effects of MSC-Exos against cadmium toxicity on male reproduction
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Structure-guided engineered urethanase from Candida parapsilosis with pH and ethanol tolerance to efficiently degrade ethyl carbamate in Chinese rice wine Ecotox. Environ. Saf. (IF 6.8) Pub Date : 2024-04-15 Xian Zhang, Yao Zhang, Tingting Fan, Zhiping Feng, Lijuan Yang
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Albiflorin ameliorates thioacetamide-induced hepatic fibrosis: The involvement of NURR1-mediated inflammatory signaling cascades in hepatic stellate cells activation Ecotox. Environ. Saf. (IF 6.8) Pub Date : 2024-04-15 Jian Song, Bo-Feng Qin, Qi-Yuan Feng, Jin-Jin Zhang, Gui-Yun Zhao, Zheng Luo, Hai-Ming Sun
Thioacetamide (TAA) within the liver generates hepatotoxic metabolites that can be induce hepatic fibrosis, similar to the clinical pathological features of chronic human liver disease. The potential protective effect of Albiflorin (ALB), a monoterpenoid glycoside found in , against hepatic fibrosis was investigated. The mouse hepatic fibrosis model was induced with an intraperitoneal injection of
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Aflatoxin B1 inhibited the development of primary myoblasts of grass carp (Ctenopharyngodon idella) by degrading extracellular matrix Ecotox. Environ. Saf. (IF 6.8) Pub Date : 2024-04-15 Xiang-Ning He, Wei-Dan Jiang, Pei Wu, Yang Liu, Hong-Mei Ren, Xiao-Wan Jin, Sheng-Yao Kuang, Ling Tang, Shu-Wei Li, Lin Feng, Xiao-Qiu Zhou
According to the International Agency for Research on Cancer (IARC), aflatoxin B1 (AFB1) has been recognized as a major contaminant in food and animal feed and which is a common mycotoxin with high toxicity. Previous research has found that AFB1 inhibited zebrafish muscle development. However, the potential mechanism of AFB1 on fish muscle development is unknown, so it is necessary to conduct further
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Potential molecular mechanism of photosynthesis regulation by PeMPK7 in poplar under para-hydroxybenzoic acid stress Ecotox. Environ. Saf. (IF 6.8) Pub Date : 2024-04-15 Xue Gao, Di Xin, Ye Zhao, Junru Li, Yangfan Cao, Shuyong Zhang, Jing Guo
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Roxithromycin exposure induces motoneuron malformation and behavioral deficits of zebrafish by interfering with the differentiation of motor neuron progenitor cells Ecotox. Environ. Saf. (IF 6.8) Pub Date : 2024-04-15 Wenjie Xie, Juntao Chen, Xiaoqian Cao, Jiannan Zhang, Juanjuan Luo, Yajun Wang
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Autophagy-dependent lysosomal calcium overload and the ATP5B-regulated lysosomes-mitochondria calcium transmission induce liver insulin resistance under perfluorooctane sulfonate exposure Ecotox. Environ. Saf. (IF 6.8) Pub Date : 2024-04-15 Jixun Li, Yu Ma, Tianming Qiu, Jianyu Wang, Jingyuan Zhang, Xiance Sun, Liping Jiang, Qiujuan Li, Xiaofeng Yao
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Effects of Streptomyces sp. HU2014 inoculation on wheat growth and rhizosphere microbial diversity under hexavalent chromium stress Ecotox. Environ. Saf. (IF 6.8) Pub Date : 2024-04-15 Hongxia Zhu, Linfeng Hu, Yunlong Wang, Peipei Mei, Feng Zhou, Tetiana Rozhkova, Chengwei Li
Wheat ( L.) is a major foodstuff for over 40% of the world’s population. However, hexavalent chromium [Cr(VI)] in contaminated soil significantly affects wheat production and its ecological environment. sp. HU2014 was first used to investigate the effects of Cr (VI) stress on wheat growth. We analyzed the Cr(VI) concentration, physicochemical properties of wheat and soil, total Cr content, and microbial
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Developmental toxicity of short-chain chlorinated paraffins on early-stage chicken embryos in a shell-less (ex-ovo) incubation system Ecotox. Environ. Saf. (IF 6.8) Pub Date : 2024-04-15 Hao Chen, Kaori Chigusa, Kazuki Kanda, Rumi Tanoue, Mari Ochiai, Hisato Iwata
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A novel perspective on di-hexyl phthalate (2-ethylhexyl)-induced reproductive toxicity in females: Lipopolysaccharide synergizes with mono-2-ethylhexyl ester to cause inflammatory apoptosis rather than autophagy in ovarian granulosa cells Ecotox. Environ. Saf. (IF 6.8) Pub Date : 2024-04-13 Bo Xu, Zhen Zhang, Hong Yang, Liyang Ding, Wenjie Dai, Ling Liu, Xing Du, Xufeng Fu, Xiuying Pei
Di-hexyl phthalate (2-ethylhexyl) (DEHP) has been confirmed to cause female reproductive toxicity in humans and model animals by affecting the survival of ovarian granulosa cells (GCs), but the interrelationships between DEHP's on autophagy, apoptosis, and inflammation in GCs are not clear. Our previous study demonstrated that DEHP exposure resulted in the disturbance of intestinal flora associated
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Hepatocyte mitochondrial DNA mediates macrophage immune response in liver injury induced by trichloroethylene Ecotox. Environ. Saf. (IF 6.8) Pub Date : 2024-04-13 Lei Gao, Xu-Lei Zuo, Luo-Lun Dong, Si-Fan Zhou, Zhou-Jian Wang, Yuan-Sheng Duan, Mu-Yue Chen, Qi-Xing Zhu, Jia-Xiang Zhang
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The relationship between aflatoxin B1 with the induction of extrinsic/intrinsic pathways of apoptosis and the protective role of taraxasterol in TM3 leydig cell line Ecotox. Environ. Saf. (IF 6.8) Pub Date : 2024-04-13 Cyrus Jalili, Ardeshir Abbasi, Nasim Rahmani-Kukia, Salar Andarzi, Seyran Kakebaraie, Touraj Zamir Nasta
Aflatoxins B1 (AFB1) a dangerous type of aflatoxin, poses a serious threat to human health. Meanwhile, Taraxasterol, a bioactive compound in dandelion, exhibits strong anti-inflammatory and antioxidant activity. Therefore, the aim of this study was to investigate the impact of AFB1 on the intrinsic and extrinsic pathways of apoptosis, as well as evaluate the protective role of taraxasterol in the TM3
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Epigenetic regulation by KDM5A mediates the effects of prenatal PM2.5 exposure on hippocampal development and synaptic integrity through the Shh signaling pathway Ecotox. Environ. Saf. (IF 6.8) Pub Date : 2024-04-13 Jia Huang, Chao Song, Yongping Liu, Tianliang Zhang, Tingting Wang, Xinqi Liu, Li Yu