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A novel approach to pH-Responsive targeted cancer Therapy: Inhibition of FaDu cancer cell proliferation with a pH low insertion Peptide-Conjugated DGAT1 inhibitor Int. J. Pharm. (IF 5.8) Pub Date : 2024-04-17 Marine Deskeuvre, Junjie Lan, Joris Messens, Olivier Riant, Olivier Feron, Raphaël Frédérick
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Novel drug-drug salt crystals of metformin with ibuprofen or naproxen: Improved solubility, dissolution rate, and synergistic antinociceptive effects Int. J. Pharm. (IF 5.8) Pub Date : 2024-04-16 Hui-Min Qin, Zheng-Kang Luo, Hui-Ling Zhou, Jin Zhu, Xin-Yi Xiao, Yang Xiao, Tao Zhuang, Gui-Sen Zhang
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Insights of biopolymeric blended formulations for diabetic wound healing Int. J. Pharm. (IF 5.8) Pub Date : 2024-04-16 Ameya Sharma, Divya Dheer, Vivek Puri, Abdulrhman Alsayari, Shadma Wahab, Prashant Kesharwani
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Plasmonic laser-responsive BioDissolve 3D-printed graphene@cisplatin-implant for prevention of post-surgical relapse of oral cancer Int. J. Pharm. (IF 5.8) Pub Date : 2024-04-15 Neelima Anup, Anuradha Gadeval, Shubham Ramdas Mule, Tanisha Gupta, Rakesh Kumar Tekade
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In-situ forming PLGA implants: Towards less toxic solvents Int. J. Pharm. (IF 5.8) Pub Date : 2024-04-15 F. Ramos, J-F. Willart, C. Neut, K. Agossa, J. Siepmann, F. Siepmann
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The drug loading capacity prediction and cytotoxicity analysis of metal–organic frameworks using stacking algorithms of machine learning Int. J. Pharm. (IF 5.8) Pub Date : 2024-04-15 Yang Wang, Liqiang He, Meijing Wang, Jiongpeng Yuan, Siwei Wu, Xiaojing Li, Tong Lin, Zihui Huang, Andi Li, Yuhang Yang, Xujie Liu, Yan He
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Digestion of surfactants does not affect their ability to inhibit P-gp-mediated transport in vitro Int. J. Pharm. (IF 5.8) Pub Date : 2024-04-15 Asbjørn Jaensch Rasmussen, Maria Pedersen, Brendan T. Griffin, René Holm, Carsten Uhd Nielsen
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Porous Functionally Graded Scaffold prepared by a single-step freeze-drying process. A bioinspired approach for wound care Int. J. Pharm. (IF 5.8) Pub Date : 2024-04-15 Barbara Vigani, Daiana Ianev, Marco Adami, Caterina Valentino, Marco Ruggeri, Cinzia Boselli, Antonia Icaro Cornaglia, Giuseppina Sandri, Silvia Rossi
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Ruxolitinib-loaded cytokine nanosponge alleviated the cytokine storm and dampened macrophage overactivation for the treatment of hemophagocytic lymphohistiocytosis Int. J. Pharm. (IF 5.8) Pub Date : 2024-04-14 Honglan Wang, Yiwei Wang, Huiwen Liu, Xuejing Li, Chunyan Sun, Zhiqing Pang, Bo Zhang, Yu Hu
Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening clinical syndrome characterized by a positive feedback loop between cytokine storm and macrophages and lymphocytes overactivation, which could serve as a valid therapeutic target for HLH treatment. In this study, the clinically extensively used JAK1/2 inhibitor ruxolitinib was encapsulated into macrophage membrane-coated nanoparticles (M@NP-R)
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Nanomicelles empower natamycin in treating fungal keratitis: An in vitro, ex vivo and in vivo study Int. J. Pharm. (IF 5.8) Pub Date : 2024-04-12 Priyadarshini Sathe, Velmurugan Kailasam, Vasagiri Nagarjuna, Hanuman Sharma, Thirumurthy Velpandian, Prashant Garg, Jayabalan Nirmal
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Nanoscale colocalized thermal and chemical mapping of pharmaceutical powder aerosols Int. J. Pharm. (IF 5.8) Pub Date : 2024-04-12 Jing Zhang, Dipesh Khanal, Hak-Kim Chan, Mark M. Banaszak Holl
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A strategy for oral delivery of FGF21 for mitigating inflammation and multi-organ damage in sepsis Int. J. Pharm. (IF 5.8) Pub Date : 2024-04-12 Xinze Li, Dedong Yu, Xuanhe Chen, Zhiwei Huang, Yingzheng Zhao
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AI-driven design of customized 3D-printed multi-layer capsules with controlled drug release profiles for personalized medicine Int. J. Pharm. (IF 5.8) Pub Date : 2024-04-12 Jingzhi Hu, Jiale Wan, Junting Xi, Wei Shi, Hai Qian
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Formulation and In Vitro-Ex vivo Evaluation of Cannabidiol and Cannabidiol-Valine-Hemisuccinate Loaded Lipid-Based Nanoformulations for Ocular Applications Int. J. Pharm. (IF 5.8) Pub Date : 2024-04-10 Ahmed Adel Ali Youssef, Muna Hayder Abdelrahman, Mona M. Geweda, Corinne Varner, Poorva H Joshi, Mihir Ghonge, Narendar Dudhipala, Suresh P Sulochana, Rama S Gadepalli, Soumyajit Majumdar
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Manufacturing process transfer to a 30 kg/h continuous direct compression line with real-time composition monitoring Int. J. Pharm. (IF 5.8) Pub Date : 2024-04-10 Adam Waněk, Lorenzo Menarini, Federica Giatti, Tomáš Kubelka, Fabrizio Consoli, Caterina Funaro, Pawel Stasiak, František Štěpánek
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Combinational strategy using albumin-based nanoparticles to enable synergetic anti-rheumatic efficacy and reduced hepatotoxicity Int. J. Pharm. (IF 5.8) Pub Date : 2024-04-10 Jiao Li, Xiqian Zhang, Lihua Pan, Xin Lin, Bin Zhang, Jianheng Ren, Qin Wang
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Critical parameters to standardize the size and concentration determination of nanomaterials by nanoparticle tracking analysis Int. J. Pharm. (IF 5.8) Pub Date : 2024-04-10 Youxi Tian, Dong Tian, Xinsheng Peng, Hong Qiu
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Enabling superior drug loading in lipid-based formulations with lipophilic salts for a brick dust molecule: Exploration of lipophilic counterions and in vitro-in vivo evaluation Int. J. Pharm. (IF 5.8) Pub Date : 2024-04-09 Arvind Sirvi, Karan Jadhav, Abhay T. Sangamwar
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Mucoadhesive polymers: Design of S-protected thiolated cyclodextrin-based hydrogels Int. J. Pharm. (IF 5.8) Pub Date : 2024-04-09 Andrea Fürst, Gergely Kali, Aida Dizdarević, Daniel Stengel, Andreas Bernkop-Schnürch
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Validation of a Caco-2 microfluidic Chip model for predicting intestinal absorption of BCS Class I-IV drugs Int. J. Pharm. (IF 5.8) Pub Date : 2024-04-08 Stephanie Y. Zhang, Whitney S.Y. Ong, Natalia Subelzu, John P. Gleeson
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Inhalable FN-binding liposomes or liposome-exosome hybrid bionic vesicles encapsulated microparticles for enhanced pulmonary fibrosis therapy Int. J. Pharm. (IF 5.8) Pub Date : 2024-04-06 Xiuhua Wang, Wei Wan, Jing Lu, Peiqing Liu
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Epigallocatechin-3-gallate derived polymer coated Prussian blue for synergistic ROS elimination and antibacterial therapy Int. J. Pharm. (IF 5.8) Pub Date : 2024-04-06 Qinqin Zhang, Yipin Zhang, Chenyang Qi, Jie Chen, Haonan Hu, Guitao Tan, Jing Tu
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Cisplatin-loaded mesoporous polydopamine nanoparticles capped with MnO2 and coated with platelet membrane provide synergistic anti-tumor therapy Int. J. Pharm. (IF 5.8) Pub Date : 2024-04-06 Yanyan Zhang, Gareth R. Williams, Tong Wang, Yilu Zheng, Jianxiang Xu, Van Cuong Nguyen, Lili Yao, Haijun Wang, Li-Min Zhu
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Pegylated liposome encapsulating docetaxel using microfluidic mixing technique: Process optimization and results in breast cancer models Int. J. Pharm. (IF 5.8) Pub Date : 2024-04-06 Mathilde Dacos, Benoît Immordino, Erwan Diroff, Guillaume Sicard, Artemis Kosta, Anne Rodallec, Sarah Giacometti, Joseph Ciccolini, Raphaëlle Fanciullino
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Corrigendum to “The effect of esomeprazole on the upper GI tract release and systemic absorption of mesalazine from colon targeted formulations” [Int. J. Pharm. 619 (2022) 121701] Int. J. Pharm. (IF 5.8) Pub Date : 2024-04-06 Arno Van Camp, Tim Vanuytsel, Joachim Brouwers, Patrick Augustijns
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RiTe conjugate mediated corneal collagen crosslinking, a novel therapeutic intervention for keratoconus – in vitro and in vivo study Int. J. Pharm. (IF 5.8) Pub Date : 2024-04-05 Harsha Rohira, Sujithra Shankar, Shikha Yadav, Priyanka P. Srivastava, Shilpi Minocha, Pravin K. Vaddavalli, Sushmita G. Shah, Archana Chugh
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Codelivery of ivermectin and methyl dihydrojasmonate in nanostructured lipid carrier for synergistic antileukemia therapy Int. J. Pharm. (IF 5.8) Pub Date : 2024-04-04 Fatma S. Abou-Elnour, Salma E. El-Habashy, Marwa M. Essawy, Ossama Y. Abdallah
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Flexible modelling of the dissolution performance of directly compressed tablets Int. J. Pharm. (IF 5.8) Pub Date : 2024-04-04 Natalie Maclean, John A. Armstrong, Mark A. Carroll, Mohammad Salehian, James Mann, Gavin Reynolds, Blair Johnston, Daniel Markl
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Analytical comparison between batch and continuous direct compression processes for pharmaceutical manufacturing using an innovative UV–Vis reflectance method and chemometrics Int. J. Pharm. (IF 5.8) Pub Date : 2024-04-04 Laura Macchietti, Dora Melucci, Lorenzo Menarini, Fabrizio Consoli, Alessandro Zappi
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A Low Transition Temperature Mixture-based viscosupplementation complemented with celecoxib for osteoarthritis treatment Int. J. Pharm. (IF 5.8) Pub Date : 2024-04-04 Ana Roda, Alexandre Paiva, Ana Rita C. Duarte
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Tannic acid coated nanosuspension for oral delivery of chrysin intended for anti-schizophrenic effect in mice Int. J. Pharm. (IF 5.8) Pub Date : 2024-04-03 Abeer Salama, Alaa Hamed Salama, Marwa Hasanein Asfour
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Polymeric nanofiber leveraged co-delivery of anti-stromal PAK1 inhibitor and paclitaxel enhances therapeutic effects in stroma-rich 3D spheroid models Int. J. Pharm. (IF 5.8) Pub Date : 2024-04-02 Ahmed M.R.H. Mostafa, Ornela Petrai, André A. Poot, Jai Prakash
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Nanodiamond-based berberine aquasomes for enhancing penetration across epidermis to treat psoriasis Int. J. Pharm. (IF 5.8) Pub Date : 2024-04-02 Samruddhi Kulkarni, Bala Prabhakar, Pravin Shende
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Conventional vs PEGylated loaded liposomal formulations by microfluidics for delivering hydrophilic chemotherapy Int. J. Pharm. (IF 5.8) Pub Date : 2024-04-02 Eman Jaradat, Adam Meziane, Dimitrios A. Lamprou
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Enhancement of subunit vaccine delivery with zinc-carnosine coordination polymer through the addition of mannan Int. J. Pharm. (IF 5.8) Pub Date : 2024-04-01 John A. Roque III, Nicole Rose Lukesh, Dylan A. Hendy, Timothy A. Dixon, Md Jahirul Islam, Luis Ontiveros-Padilla, Erik S. Pena, Liubov M. Lifshits, Sean R. Simpson, Cole J. Batty, Eric M. Bachelder, Kristy M. Ainslie
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A self-healing crosslinked-xanthan gum/soy protein based film containing halloysite nanotube and propolis with antibacterial and antioxidant activity for wound healing Int. J. Pharm. (IF 5.8) Pub Date : 2024-04-01 Farnaz Jaberifard, Yasir Q. Almajidi, Nasser Arsalani, Marjan Ghorbani
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A novel FK506-loading mesoporous silica nanoparticle homing to lymph nodes for transplant rejection treatment Int. J. Pharm. (IF 5.8) Pub Date : 2024-03-31 Yishu Song, Qiaofeng Jin, Binqian Zhou, Cheng Deng, Wuqi Zhou, Wenqu Li, Luyang Yi, Mengdan Ding, Yihan Chen, Tang Gao, Li Zhang, Mingxing Xie
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Nanoparticle-mediated immunogenic cell death for cancer immunotherapy Int. J. Pharm. (IF 5.8) Pub Date : 2024-03-30 Haolong Qi, Yuan Li, Yingjie Geng, Xinhuan Wan, Xiaoqing Cai
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Integration of caveolin-mediated cytosolic delivery and enzyme-responsive releasing of squalenoyl nanoparticles enhance the anti-cancer efficacy of chidamide in pancreatic cancer Int. J. Pharm. (IF 5.8) Pub Date : 2024-03-30 Junyan Chen, Kaidi Chen, Shuai Xue, Xiao Cheng, Yuwei Qi, Hangjie Wang, Wei Li, Guilin Cheng, Yang Xiong, Chaofeng Mu, Mancang Gu
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Parafilm® M and Strat-M® as skin simulants in in vitro permeation of dissolving microarray patches loaded with proteins Int. J. Pharm. (IF 5.8) Pub Date : 2024-03-29 Qonita Kurnia Anjani, Avelia Devina Calista Nainggolan, Huanhuan Li, Andang Miatmoko, Eneko Larrañeta, Ryan F. Donnelly
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Liposomal drug delivery strategies to eradicate bacterial biofilms: Challenges, recent advances, and future perspectives Int. J. Pharm. (IF 5.8) Pub Date : 2024-03-29 Vijay Kumar Panthi, Kathryn E. Fairfull-Smith, Nazrul Islam
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Tableting behavior of freeze and spray-dried excipients in pharmaceutical formulations Int. J. Pharm. (IF 5.8) Pub Date : 2024-03-28 Charbel Madi, Hassana Hsein, Virginie Busignies, Pierre Tchoreloff, Vincent Mazel
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Rheological insights into 3D printing of drug products: Drug nanocrystal-poloxamer gels for semisolid extrusion Int. J. Pharm. (IF 5.8) Pub Date : 2024-03-28 Atte Junnila, Laurence Mortier, Alba Arbiol, Elina Harju, Teemu Tomberg, Jouni Hirvonen, Tapani Viitala, Anssi-Pekka Karttunen, Leena Peltonen
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A floating 3D printed polypill formulation for the coadministration and sustained release of antihypertensive drugs Int. J. Pharm. (IF 5.8) Pub Date : 2024-03-28 Paola Zgouro, Orestis L. Katsamenis, Thomas Moschakis, Georgios K. Eleftheriadis, Athanasios S. Kyriakidis, Konstantina Chachlioutaki, Paraskevi Kyriaki Monou, Marianna Ntorkou, Constantinos K. Zacharis, Nikolaos Bouropoulos, Dimitrios G. Fatouros, Christina Karavasili, Christos I. Gioumouxouzis
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The search for novel proline analogs for viscosity reduction and stabilization of highly concentrated monoclonal antibody solutions Int. J. Pharm. (IF 5.8) Pub Date : 2024-03-28 Monika Prašnikar, Matic Proj, Maja Bjelošević Žiberna, Blaž Lebar, Benjamin Knez, Nika Kržišnik, Robert Roškar, Stanislav Gobec, Iztok Grabnar, Aleš Žula, Pegi Ahlin Grabnar
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Synthesis of biocomposites from microalgal peptide incorporated polycaprolactone/ κ- carrageenan nanofibers and their antibacterial and wound healing property Int. J. Pharm. (IF 5.8) Pub Date : 2024-03-28 Sathya Raghunathan, Sangeetha Kandasamy, Agieshkumar Balakrishna Pillai, Daisy Precilla Senthilathiban, Nooruddin Thajuddin, Majid Rasool Kamli, Jamal S.M. Sabir, Sang-Yul Lee, Jung-Wan Kim, MubarakAli Davoodbasha
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Unlocking the power of immunotherapy: Combinatorial delivery of plasmid IL-15 and gemcitabine to synergistically remodeling the tumor microenvironment Int. J. Pharm. (IF 5.8) Pub Date : 2024-03-28 Jingwen Liu, Yanyan Han, Ming Zhao, Leyuan Wang, Haiyang Hu, Dawei Chen
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Gold nanoparticles-mediated photothermal and photodynamic therapies for cancer Int. J. Pharm. (IF 5.8) Pub Date : 2024-03-27 Seyma Nur Turkmen Koc, Sanam Rezaei Benam, Ipek Pınar Aral, Reza Shahbazi, Kezban Ulubayram
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Design and development of dual drug-loaded nanofibrous inserts for ophthalmic sustained delivery of AMK and VAN: Pharmacokinetic study in rabbit’s eye Int. J. Pharm. (IF 5.8) Pub Date : 2024-03-26 Shiva Taghe, Shahla Mirzaeei, Tanin Hosseinkhani
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Development of a hydrogel containing bisabolol-loaded nanocapsules for the treatment of atopic dermatitis in a Balb/c mice model Int. J. Pharm. (IF 5.8) Pub Date : 2024-03-26 Homa Karami, Mohammad Reza Niavand, Rasool Haddadi, Alireza Noriyan, Seyed Yaser Vafaei
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PEGylated mesoporous silica core–shell redox-responsive nanoparticles for delivering paclitaxel to breast cancer cells Int. J. Pharm. (IF 5.8) Pub Date : 2024-03-26 Saeed Shahbaz, Mahta Esmaeili, Mohammad Hosein Fathian Nasab, Zhila Imani, Reza Bafkary, Mohsen Amini, Fatemeh Atyabi, Rassoul Dinarvand
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Phase transforming in situ gels for sustained and controlled transmucosal drug delivery via the intravaginal route Int. J. Pharm. (IF 5.8) Pub Date : 2024-03-26 Ritu Thapa, Preeti Pandey, Marie-Odile Parat, Shila Gurung, Harendra S. Parekh
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Bioavailability enhancement of sildenafil citrate via hydrogel-forming microneedle strategy in combination with cyclodextrin complexation Int. J. Pharm. (IF 5.8) Pub Date : 2024-03-26 Sulistiawati Sulistiawati, Cindy Kristina Enggi, Israini Wiyulanda Iskandar, Rizki Rachmad Saputra, Sartini Sartini, Yusnita Rifai, Latifah Rahman, Muhammad Aswad, Andi Dian Permana
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Liposome-siderophore conjugates loaded with moxifloxacin serve as a model for drug delivery against Mycobacterium tuberculosis Int. J. Pharm. (IF 5.8) Pub Date : 2024-03-26 Camila Maringolo Ribeiro, Cesar Augusto Roque-Borda, Maria Carolina Franzini, Karyn Fernanda Manieri, Fernanda Manaia Demarqui, Débora Leite Campos, Rachel Temperani Amaral Machado, Isabel Cristiane da Silva, Marcela Tavares Luiz, Leonardo Delello Di Filippo, Patrícia Bento da Silva, Márcia Cristina Oliveira da Rocha, Sônia Nair Báo, Domiziana Masci, Guilherme F.S. Fernandes, Daniele Castagnolo, Marlus
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Fabrication, optimization, and evaluation of lyophilized lacidipine-loaded fatty-based nanovesicles as orally fast disintegrating sponge delivery system Int. J. Pharm. (IF 5.8) Pub Date : 2024-03-26 Rania Moataz El-Dahmy, Ahmed Hassen Elshafeey, Yasmin Ahmed El-Feky
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Ultrasound imaging guided targeted sonodynamic therapy enhanced by magnetophoretically controlled magnetic microbubbles Int. J. Pharm. (IF 5.8) Pub Date : 2024-03-26 Yao Zhu, Gulzira Arkin, Tianzhen He, Fengjuan Guo, Ling Zhang, Yu Wu, Paras N. Prasad, Zhongjian Xie
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Design of smart chemotherapy of doxorubicin hydrochloride using nanostructured lipid carriers and solid lipid nanoparticles for improved anticancer efficacy Int. J. Pharm. (IF 5.8) Pub Date : 2024-03-25 Sooho Yeo, Huiqiang Wu, Il Yoon, Woo Kyoung Lee, Sung-Joo Hwang
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In vitro studies into establishing therapeutic bioequivalence of complex topical products: Weight of evidence Int. J. Pharm. (IF 5.8) Pub Date : 2024-03-25 Margarida Miranda, Zoe Volmer, Alicia Cornick, Aidan Goody, Catarina Cardoso, Alberto A.C.C. Pais, Marc Brown, Carla Vitorino
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Corrigendum to “IFN-γ gene loaded human umbilical mesenchymal stromal cells targeting therapy for Graft-versus-host disease” [Int. J. Pharm. 592 (2021) 120058] Int. J. Pharm. (IF 5.8) Pub Date : 2024-03-25 Hui Li, Qi Liu, Xiaofeng Gao, Di zhang, Shengjun Mao, Yongqian Jia
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Machine learning modeling for ultrasonic quality attribute assessment of pharmaceutical tablets for continuous manufacturing and real-time release testing Int. J. Pharm. (IF 5.8) Pub Date : 2024-03-25 Tipu Sultan, Enamul Hasan Rozin, Shubhajit Paul, Yin-Chao Tseng, Vivek S. Dave, Cetin Cetinkaya