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Epidermal second-hit mutation in MVK gene associated with linear porokeratosis Genes Dis. (IF 6.8) Pub Date : 2024-04-29 Anqi Zhao, Xinyi Wang, Chaolan Pan, Yumeng Wang, Qiaoyu Cao, Min Li, Ming Li
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Treating human cancer by targeting EZH2 Genes Dis. (IF 6.8) Pub Date : 2024-04-25 Mengfei Xu, Chunyan Xu, Rui Wang, Qing Tang, Qichun Zhou, Wanyin Wu, Xinliang Wan, Handan Mo, Jun Pan, Sumei Wang
Enhancer of zeste homolog 2 (EZH2), an epigenetic regulator that primarily inhibits downstream gene expression by tri-methylating histone H3, which is usually overexpressed in tumors and participates in many processes such as tumor occurrence and development, invasion, migration, drug resistance, and anti-tumor immunity as an oncogene, making it an important biomarker in cancer therapy. Collectively
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ZIP4 inhibits Ephrin-B1 ubiquitination, activating Wnt5A/JNK/ZEB1 to promote liver cancer metastasis Genes Dis. (IF 6.8) Pub Date : 2024-04-24 Haijun Guo, Renyi Su, Xinfeng Lu, Hui Zhang, Xuyong Wei, Xiao Xu
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BBOX1, LACC1, MMP7 and SSTR1 as common predictors in obesity and non-alcoholic fatty liver disease Genes Dis. (IF 6.8) Pub Date : 2024-04-24 Chaoyuan Huang, Guoming Chen, Dongqiang Luo, Jiyuan Zheng, Nan Zhong, Danyun Li, Yang Luo, Peizhen Huang, Ning Wang, Yibin Feng, Yiyuan Zheng
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Rare dentin defects: Understanding the pathophysiological mechanisms of COLXVA1 mutations Genes Dis. (IF 6.8) Pub Date : 2024-04-20 Isaac Maximiliano Bugueno, Tristan Rey, Alexandra Jimenez-Armijo, Marzena Kawczynski, Naji Kharouf, Marie-Cécile Manière, Yann Herault, Agnès Bloch-Zupan, Virginie Haushalter-Laugel
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Key roles of ubiquitination in regulating critical regulators of cancer stem cell functionality Genes Dis. (IF 6.8) Pub Date : 2024-04-17 Qianqian Guo, Hai Qin, Zelong Chen, Wenzhou Zhang, Lufeng Zheng, Tingting Qin
The ubiquitin (Ub) system, a ubiquitous presence across eukaryotes, plays a crucial role in the precise orchestration of diverse cellular protein processes. From steering cellular signaling pathways and orchestrating cell cycle progression to guiding receptor trafficking and modulating immune responses, this process plays a crucial role in regulating various biological functions. The dysregulation
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Vitamin D binding protein in psychiatric and neurological disorders: Implications for diagnosis and treatment Genes Dis. (IF 6.8) Pub Date : 2024-04-15 Ling Li, Bing Han, Yan Kong, Gaojia Zhang, Zhijun Zhang
Vitamin D binding protein (VDBP) serves as a key transporter protein responsible for binding and delivering vitamin D and its metabolites to target organs. VDBP plays a crucial part in the inflammatory reaction following tissue damage and is engaged in actin degradation. Recent research has shed light on its potential role in various diseases, leading to a growing interest in understanding the implications
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The multifaceted role of post-translational modifications of LSD1 in cellular processes and disease pathogenesis Genes Dis. (IF 6.8) Pub Date : 2024-04-15 Yinrui Li, Bo Wang, Yichao Zheng, Huiqin Kang, Ang He, Lijuan Zhao, Ningjie Guo, Hongmin Liu, Adil Mardinoglu, M.A.A. Mamun, Ya Gao, Xiaobing Chen
Post-translational modifications (PTMs) of proteins play a crucial role in living organisms, altering the properties and functions of proteins. There are over 450 known PTMs involved in various life activities. LSD1 (lysine-specific demethylase 1) is the first identified histone demethylase that can remove monomethylation or dimethylation modifications from histone H3 lysine K4 (H3K4) and histone H3
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Sonic Hedgehog potentiates BMP9-induced osteogenic differentiation of mesenchymal stem cells Genes Dis. (IF 6.8) Pub Date : 2024-04-14 Lulu Zhang, Caixia Ji, Ziyun Li, Habu Jiwa, Zhou Xie, Xiaoji Luo, Jinyong Luo
Bone morphogenetic protein 9 (BMP9) has remarkable potential to induce the differentiation of mesenchymal stem cells (MSCs) towards the osteoblastic lineage. Additionally, research suggests that certain growth factors have the ability to potentiate BMP9-induced osteogenic differentiation of MSCs. Sonic Hedgehog (Shh) plays an indispensable role in the regulation of skeletal development. The objective
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Profiling the cell diversity and tissue structure of aqueous humor circulatory system in human eyes using spatial single-cell RNA sequencing Genes Dis. (IF 6.8) Pub Date : 2024-04-12 Hao Yuan, Zhaona Song, Xiao Sun, Chunping Song, Lidong Guo, Qiang Zhang, Yonglun Luo, Chengfu Yuan, Jianlu Gao, Xiaodong Jia
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The crosstalk between non-coding RNAs and oxidative stress in cancer progression Genes Dis. (IF 6.8) Pub Date : 2024-04-10 Qiqi Sun, Xiaoyong Lei, Xiaoyan Yang
As living standards elevate, cancers are appearing in growing numbers among younger individuals globally and these risks escalate with advancing years. One of the reasons is that instability in the cancer genome reduces the effectiveness of conventional drug treatments and chemotherapy, compared with more targeted therapies. Previous research has discovered non-coding RNAs' crucial role in shaping
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Glucose metabolism perturbations influence tumor microenvironments via LINC01139 pathway and facilitate immunotherapy in hepatocellular carcinoma Genes Dis. (IF 6.8) Pub Date : 2024-04-08 Yueying Gao, Jinyang Yu, Zhi Li, Kefan Liu, Jiwei Pan, Ya Zhang, Yanlin Ma, Jiwei Zhang, Zhigang Liu, Yongsheng Li
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The 21-base pair deletion mutant Calpain3 does not inhibit wild-type Calpain3 activity Genes Dis. (IF 6.8) Pub Date : 2024-04-08 Swati Maitra, Seungjae Oh, Yun-Jeong Choe, JiHye Kim, Nam Chul Kim
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Novel oral compound Z526 mitigates cancer-associated cachexia via intervening NF-κB signaling and oxidative stress Genes Dis. (IF 6.8) Pub Date : 2024-04-08 Xiaofan Gu, Shanshan Lu, Shuang Xu, Yiwei Li, Meng Fan, Guangyu Lin, Yiyuan Liu, Yun Zhao, Weili Zhao, Xuan Liu, Xiaochun Dong, Xiongwen Zhang
Cancer-associated cachexia (CAC) is a severe metabolic disorder syndrome mainly characterized by muscle and fat loss, which accounts for one-third of cancer-related deaths. No effective therapeutic approach that could fully reverse CAC is available. NF-κB signaling and oxidative stress play vital roles in both muscle atrophy and fat loss in CAC. Here, we showed that our developed oral compound Z526
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Novel heterozygous missense variants in the TOE1 gene linked to pontocerebellar hypoplasia type 7 Genes Dis. (IF 6.8) Pub Date : 2024-04-08 Aijun Yang, Xiaoli Kong, Qin Wang, Runqing Miao, Haixiang Ma, Anzhuo Chu, Zhengtong Wang, Jiaqing Lu, Bo Liu, Bingcheng Mu, Runhan Guo, Jiayi Li, Xiaoxiao Gongye, Huabao Xiong, Tao Zhong
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TFR2 gene alterations in idiopathic erythrocytosis reinforce a possible relation between erythrocytosis and iron metabolism Genes Dis. (IF 6.8) Pub Date : 2024-04-05 Andrea Benetti, Irene Bertozzi, Maria Luigia Randi
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Aging-related inflammatory and metabolic disorder in the novel mutation of colony-stimulating factor-1 receptor (csf1r)P853T/+ in CSF1R-microglial encephalopathy Genes Dis. (IF 6.8) Pub Date : 2024-04-05 Xiaohong Wang, Yanli Wang, Tianlin Jiang, Jiwei Jiang, Linlin Wang, Shiyi Yang, Mengfan Sun, Yuan Zhang, Ziyan Jia, Wenyi Li, Qiwei Ren, Cuicui Zhang, Jianjian Liu, Yinwei Zhu, Jun Xu
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TULP4 degrades RYBP to enhance DNA damage repair and chemosensitivity of pancreatic ductal adenocarcinoma Genes Dis. (IF 6.8) Pub Date : 2024-04-05 Jingyao Dai, Su Liu, Yangyang Xie, Yixuan Wang, Xiyun Bian, Tian Yu, Tiantian Li, Linchuang Jia, Zhigang Zhao, Zhiqiang Liu, Xiaozhi Liu
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MicroRNAs in adipose tissue fibrosis: Mechanisms and therapeutic potential Genes Dis. (IF 6.8) Pub Date : 2024-04-05 Mei Tian, Yang Zhou, Yitong Guo, Qing Xia, Zehua Wang, Xinying Zheng, Jinze Shen, Junping Guo, Shiwei Duan, Lijun Wang
Adipose tissue fibrosis, characterized by abnormal extracellular matrix deposition within adipose tissue, signifies a crucial indicator of adipose tissue malfunction, potentially leading to organ tissue dysfunction. Various factors, including a high-fat diet, non-alcoholic fatty liver disease, and insulin resistance, coincide with adipose tissue fibrosis. MicroRNAs (miRNAs) represent a class of small
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Inhibiting HMGCR represses stemness and metastasis of hepatocellular carcinoma via Hedgehog signaling Genes Dis. (IF 6.8) Pub Date : 2024-04-03 Zhirong Zhang, Jiayao Yang, Rui Liu, Jing Ma, Kai Wang, Xiaojun Wang, Ni Tang
Cancer stem cells (CSCs) play a crucial role in tumor initiation, recurrence, metastasis, and drug resistance. However, the current understanding of CSCs in hepatocellular carcinoma (HCC) remains incomplete. Through a comprehensive analysis of the database, it has been observed that 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR), a critical enzyme involved in cholesterol metabolism, is up-regulated
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The effect of long-term administration of green tea catechins on aging-related cardiac diastolic dysfunction and decline of troponin I Genes Dis. (IF 6.8) Pub Date : 2024-04-03 Junjun Quan, Zhongli Jia, Lingjuan Liu, Jie Tian
Aging is an independent risk factor for cardiovascular diseases. Cardiac diastolic dysfunction (CDD), ultimately leading to heart failure with preserved ejection fraction, is prevalent among older individuals. Although therapeutics have made great progress, preventive strategies remain unmet medical needs. Green tea catechins have been shown to be effective in improving aging-related cardiovascular
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Expanding the spectrum of novel candidate genes using trio exome sequencing and identification of monogenic cause in 27.5% of 320 families with steroid-resistant nephrotic syndrome Genes Dis. (IF 6.8) Pub Date : 2024-03-28 Ronen Schneider, Shirlee Shril, Florian Buerger, Konstantin Deutsch, Kirollos Yousef, Camille N. Frank, Ana C. Onuchic-Whitford, Thomas M. Kitzler, Youying Mao, Verena Klämbt, Muhammad Y. Zahoor, Katharina Lemberg, Amar J. Majmundar, Bshara Mansour, Ken Saida, Steve Seltzsam, Caroline M. Kolvenbach, Lea Maria Merz, Nils D. Mertens, Tobias Hermle, Nina Mann, Dalia Pantel, Abdul A. Halawi, Aaron Bao
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Peritoneal adipose stem cell-derived extracellular vesicles mediate the regulation of ovarian cancer cell proliferation and migration through EGFR-NF-κB signaling Genes Dis. (IF 6.8) Pub Date : 2024-03-28 Lian Wang, Ning Luo, Jihui Zhu, Zubaidan Sulaiman, Wenhan Yang, Ke Hu, Guihai Ai, Weihong Yang, Xiaowen Shao, Shengkai Jin, Xue Zhang, Yantao Fan, Dan Deng, Zhongping Cheng, Zhengliang Gao
Peritoneal dissemination frequently develops in patients with ovarian cancer (OC) and is associated with recurrence and metastasis. However, the cellular components and mechanisms supporting OC peritoneal metastasis are poorly understood. To elucidate these, we utilized RNA sequencing to investigate the cellular composition and function. Insights from transcriptome analyses suggested that OC cells
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Disruption of mitochondrial DNA integrity in cardiomyocyte injury upon ischemia/reperfusion Genes Dis. (IF 6.8) Pub Date : 2024-03-28 Shengnan Hu, Xueying Tang, Fangrui Zhu, Chen Liang, Sa Wang, Hongjie Wang, Peifeng Li, Yuzhen Li
Mitochondria serve as the energy provider and enable life activities, and they are the only organelles containing extra-chromosomal DNA. Each mitochondrion contains multiple copies of its genome, which is usually referred to as mitochondrial DNA (mtDNA). mtDNA encodes necessary electron transport chain complex subunits, as well as the essential RNAs for their translation within the organelle. Therefore
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STIM1 promotes acquired resistance to sorafenib by attenuating ferroptosis in hepatocellular carcinoma Genes Dis. (IF 6.8) Pub Date : 2024-03-28 Ran Ren, Yu Chen, Yu Zhou, Luyao Shen, Yang Chen, Juan Lei, Jingchun Wang, Xudong Liu, Nan Zhang, Dongqin Zhou, Huakan Zhao, Yongsheng Li
Dysregulated calcium (Ca) signaling pathways are associated with tumor cell death and drug resistance. In non-excitable cells, such as hepatocellular carcinoma (HCC) cells, the primary pathway for Ca influx is through stromal interaction molecule 1 (STIM1)-mediated store-operated calcium entry (SOCE). Previous studies have demonstrated the involvement of STIM1-mediated SOCE in processes such as genesis
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MDM2 inhibitors in cancer immunotherapy: Current status and perspective Genes Dis. (IF 6.8) Pub Date : 2024-03-28 Qinru Zeng, Shaocheng Zeng, Xiaofeng Dai, Yun Ding, Chunye Huang, Ruiwen Ruan, Jianping Xiong, Xiaomei Tang, Jun Deng
Murine double minute 2 (MDM2) plays an essential role in the cell cycle, apoptosis, DNA repair, and oncogene activation through p53-dependent and p53-independent signaling pathways. Several preclinical studies have shown that MDM2 is involved in tumor immune evasion. Therefore, MDM2-based regulation of tumor cell-intrinsic immunoregulation and the immune microenvironment has attracted increasing research
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Transcriptional programs associated with luminal play a vital role in invasive mucinous lung adenocarcinoma Genes Dis. (IF 6.8) Pub Date : 2024-03-26 Shufan Zhang, Rong Jiang, Changguo Wang, Manqiu Yang, Tao Wang, Jianzhou Cui, Guangbin Li, Shaomu Chen, Moli Huang
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CD147 facilitates cisplatin resistance in ovarian cancer through FOXM1 degradation inhibition Genes Dis. (IF 6.8) Pub Date : 2024-03-24 Miao Wang, Lin Chen, Yu Wang, Tian Fan, Chunyu Zhu, Zhixian Li, Lei Mou, Hong Yang, Airong Qian, Yu Li
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Reduction of Atp5b protects mice from diet-induced obesity Genes Dis. (IF 6.8) Pub Date : 2024-03-22 Xiaohua Huang, Binting Qin, Zhengfeng Fang, Lianqiang Che, Yan Lin, Shengyu Xu, Yong Zhuo, Lun Hua, Xuemei Jiang, Mengmeng Sun, Hairui Wang, De Wu, Qingqiang Long, Bin Feng
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Predicting anti-cancer drug sensitivity through WRE-XGBoost algorithm with weighted feature selection Genes Dis. (IF 6.8) Pub Date : 2024-03-22 Yiyao Jiang, Ming Chen, Zhongmin Xiong, Yufang Qin
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The important role and core marker gene of tumor-infiltrating plasma cells in the microenvironment of lung adenocarcinoma Genes Dis. (IF 6.8) Pub Date : 2024-03-22 Jianhong Zhang, Chengyang Song, Xiuqin Feng, Qian Yu, Xueying Yang
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Corrigendum to “SEMA4D acts as a novel oligogenic pathogenic gene of idiopathic hypogonadotropic hypogonadism through the PlexinB1/MET/RND1/RHOA/RAF1/MAPK signaling axis” [Genes & Diseases 10 (2023) 65–68] Genes Dis. (IF 6.8) Pub Date : 2024-03-22 Daoqi Wang, Yonghua Niu, Jiahong Tan, Jiaxin Wang, Le Ling, Yinwei Chen, Jianan Gong, Hao Xu, Qing Ling, Jianhe Liu, Jihong Liu
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A novel metabolite-interacting protein (MIP)-based molecular subtyping construction and validation of IGFBP3 as a MIP-related oncogene in colorectal cancer Genes Dis. (IF 6.8) Pub Date : 2024-03-22 Simeng Bao, Yongmin Li, Yu Liang, Jianxun Dai, Huolin Huang, Bin Ma
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The link between ten-eleven translocation-2 (Tet2) related clonal hematopoiesis and sequential onset of two hematologic malignancies Genes Dis. (IF 6.8) Pub Date : 2024-03-22 Jin Huang, Haolong Lin, Xia Mao, Min Xiao, Xiaoxi Zhou, Qilin Ao, Liang Huang
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Integrating single-cell RNA sequencing and bulk RNA sequencing data to predict acute respiratory distress syndrome in sepsis patients Genes Dis. (IF 6.8) Pub Date : 2024-03-19 Miao Wang, Xiaoer Jin, Qingbo Liao, Yufan Pu, Xiaowen Xu, Xiaoqiang Ren, Gaoqing Liu, Zhiwei Zhuang, Qi Ding
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Identification of AAV serotypes for gene therapy in Krabbe iPSCs-derived brain organoids Genes Dis. (IF 6.8) Pub Date : 2024-03-19 Yafeng Lv, Zhi Cui, Hongbo Li, Jing Wang, Mulan Wei, Yuanlang Hu, Xun Li, Chunyu Cao, Ye Zhang, Wei Wang
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NUF2 overexpression predicts poor outcomes in multiple myeloma Genes Dis. (IF 6.8) Pub Date : 2024-03-19 Shanshan Zhang, Li Zhang, Linjing Cai, Huan Chen, Yuqi Wang, Youhai Yuan, Hanzhen Zhang, Xiaolei Wei
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VPS13D affects epileptic seizures by regulating mitochondrial fission and autophagy in epileptic rats Genes Dis. (IF 6.8) Pub Date : 2024-03-19 Jian Wang, Fan Zhang, Zhong Luo, Haiqing Zhang, Xin Tian, Changyin Yu, Zucai Xu
Abnormal mitochondrial dynamics can lead to seizures, and improved mitochondrial dynamics can alleviate seizures. Vacuolar protein sorting 13D (VPS13D) is closely associated with regulating mitochondrial homeostasis and autophagy. However, further investigation is required to determine whether VPS13D affects seizures by influencing mitochondrial dynamics and autophagy. We aimed to investigate the influence
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The combination of SLC7A11 inhibitor and oridonin synergistically inhibits cervical cancer cell growth by decreasing the NADPH/NADP+ ratio Genes Dis. (IF 6.8) Pub Date : 2024-03-19 Yajie Liu, Pengxing He, Xubin Ma, Yingqi Tian, Yu Zhang, Yang Wang, Yingjie Jia, Hongmin Liu, Ying Liu, Yichao Xu
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Mechanosensitive adhesion G protein-coupled receptors: Insights from health and disease Genes Dis. (IF 6.8) Pub Date : 2024-03-16 Shiying Sun, Wen Wang
Ontogeny cannot be separated from mechanical forces. Cells are continuously subjected to different types of mechanical stimuli that convert into intracellular signals through mechanotransduction. As a member of the G protein-coupled receptor superfamily, adhesion G protein-coupled receptors (aGPCRs) have attracted extensive attention due to their unique extracellular domain and adhesion properties
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Focus on cardiac troponin complex: From gene expression to cardiomyopathy Genes Dis. (IF 6.8) Pub Date : 2024-03-11 Rosetta Ragusa, Chiara Caselli
The cardiac troponin complex (cTn) is a regulatory component of sarcomere. cTn consists of three subunits: cardiac troponin C (cTnC), which confers Ca sensitivity to muscle; cTnI, which inhibits the interaction of cross-bridge of myosin with thin filament during diastole; and cTnT, which has multiple roles in sarcomere, such as promoting the link between the cTnI-cTnC complex and tropomyosin within
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Pdgfrα+ stromal cells, a key regulator for tissue homeostasis and dysfunction in distinct organs Genes Dis. (IF 6.8) Pub Date : 2024-03-09 Xia Kang, Kun Zhao, Zhu Huang, So-ichiro Fukada, Xiao-wei Qi, Hongming Miao
Pdgfrα stromal cells are a group of cells specifically expressing Pdgfrα, which may be mentioned with distinct names in different tissues. Importantly, the findings from numerous studies suggest that these cells share exactly similar biomarkers and properties, show complex functions in regulating the microenvironment, and are critical to tissue regeneration, repair, and degeneration. Comparing the
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Iron promotes both ferroptosis and necroptosis in the early stage of reperfusion in ischemic stroke Genes Dis. (IF 6.8) Pub Date : 2024-03-08 Bin Du, Zijie Deng, Kang Chen, Zhangzhong Yang, Junfen Wei, Liuyao Zhou, Jie Meng, Ying Cheng, Xin Tian, Qingzhang Tuo, Peng Lei
Programmed cell death contributes to neurological damage in ischemic stroke, especially during the reperfusion stage. Several cell death pathways have been tested preclinically and clinically, including ferroptosis, necroptosis, and apoptosis. However, the sequence and complex interplay between cell death pathways during ischemia/reperfusion remains under investigation. Here, we unbiasedly investigated
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mTOR pathway: A key player in diabetic nephropathy progression and therapeutic targets Genes Dis. (IF 6.8) Pub Date : 2024-03-08 Jingxuan Shi, Xinze Liu, Yuanyuan Jiao, Jingwei Tian, Jiaqi An, Guming Zou, Li Zhuo
Diabetic nephropathy is a prevalent complication of diabetes and stands as the primary contributor to end-stage renal disease. The global prevalence of diabetic nephropathy is on the rise, however, due to its intricate pathogenesis, there is currently an absence of efficacious treatments to enhance renal prognosis in affected patients. The mammalian target of rapamycin (mTOR), a serine/threonine protease
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Identification of ferroptosis/autophagy-related genes and potential underlying mechanisms involved in the effect of BMSC senescence on the osteogenic differentiation of aging BMSCs Genes Dis. (IF 6.8) Pub Date : 2024-03-08 Kai Chen, Huaqiang Tao, Haixiang Xiao, Miao Chu, Pengfei Zhu, Shujun Lv, Lixin Huang, Dechun Geng
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Time-series transcriptome analysis mapping pulmonary immune checkpoint atlas of experimental silicosis Genes Dis. (IF 6.8) Pub Date : 2024-03-08 Youliang Zhao, Yuanmeng Qi, Meixiu Duan, Changfu Hao, Wu Yao
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EBF1 expressed in the dermal papilla regulates hair type and length Genes Dis. (IF 6.8) Pub Date : 2024-03-07 Hongzhi Song, Lei Zhang, Wei-qi Zhong, Eve Qian Chen, Xi-Xi Qiu, Zi-Ling Tang, Xin-Hua Liao
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Disulfidptosis heterogeneity in breast cancer uncovers PTTG1IP as an actionable therapeutic target Genes Dis. (IF 6.8) Pub Date : 2024-03-05 Kun Fang, Suxiao Jiang, Zhengjie Xu, Meng Luo, Changsheng Yan
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Single-cell transcriptomics illustrates the immune inflammatory responses of septic mice spleen after capsaicin treatment Genes Dis. (IF 6.8) Pub Date : 2024-03-05 Weijin Qiu, Qian Zhang, Jing Liu, Xueling He, Guangqing Cheng, Jiayun Chen, Yunmeng Bai, Piao Luo, Ping Gong, Fei Shi, Jigang Wang
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Heterogeneity of anoikis in triple-negative breast cancer subtyping and therapeutic implications Genes Dis. (IF 6.8) Pub Date : 2024-03-04 Kun Fang, Suxiao Jiang, Zhengjie Xu, Meng Luo, Changsheng Yan
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CircAkap7: A novel circular RNA with a role in doxorubicin-induced cardiotoxicity Genes Dis. (IF 6.8) Pub Date : 2024-03-02 Jiaqin Liu, Sa Liu, Xiangyun Li, Shanshan Wei, Taoli Sun, Ning Xie, Bikui Zhang, Wenqun Li
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Coupled single-cell and bulk RNA-seq analysis reveals the engulfment role of endothelial cells in atherosclerosis Genes Dis. (IF 6.8) Pub Date : 2024-03-02 Jianxiong Xu, Jinxuan Wang, Hongping Zhang, Yidan Chen, Xiaojuan Zhang, Ying Zhang, Ming Xie, Jun Xiao, Juhui Qiu, Guixue Wang
The clearance of apoptotic cell debris, containing professional phagocytosis and non-professional phagocytosis, is essential for maintaining the homeostasis of healthy tissues. Here, we discovered that endothelial cells could engulf apoptotic cell debris in atherosclerotic plaque. Single-cell RNA sequencing (RNA-seq) has revealed a unique endothelial cell subpopulation in atherosclerosis, which was
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Regulation of SLC7A11 as an unconventional checkpoint in tumorigenesis through ferroptosis Genes Dis. (IF 6.8) Pub Date : 2024-03-02 Zhenyi Su, Yanqing Liu, Lin Wang, Wei Gu
Although cell-cycle arrest, senescence, and apoptosis are well accepted as the classic barriers in tumorigenesis, recent studies indicate that metabolic regulation is equally important as a major checkpoint in cancer development. It is well accepted that ferroptosis, an iron-dependent programmed cell death, acts as a new type of tumor suppression mechanism tightly linked with numerous metabolic pathways
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Single nucleotide polymorphisms: Implications in the early diagnosis and targeted intervention of coronary microvascular dysfunction Genes Dis. (IF 6.8) Pub Date : 2024-02-28 Dingyuan Tian, Jie Li, Xiaoyue Lai, Qingyuan Yang, Zhihui Zhang, Fang Deng
Coronary microvascular dysfunction (CMD) is a clinical syndrome of myocardial ischemia caused by structural and/or functional abnormalities of pre-coronary arterioles and arterioles. While genetics and other factors play a role in CMD etiology, the key pathogenic mechanism remains unclear. Currently, the diagnostic procedure for CMD is still cumbersome, and there is a lack of effective targeted interventions
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TNFα-reliant FSP1 up-regulation promotes intervertebral disc degeneration via caspase 3-dependent apoptosis Genes Dis. (IF 6.8) Pub Date : 2024-02-28 Cheng Qiu, Lin Cheng, Derun Di, Ziqian Xiang, Congyu Wang, Jinghang Li, Yinuo Xiong, Manyu Li, Jingwei Liu, Jian Zhou, Tianyi Liu, Xinyu Wang, Dan Luo, Xiaoxiong Wang, Shangye Li, Hui Wang, Xia Wang, Yunpeng Zhao, Xinyu Liu, Lianlei Wang
Intervertebral disc degeneration (IDD) is a common chronic inflammatory degenerative disease that causes lower back pain. However, the underlying mechanisms of IDD remain unclear. Ferroptosis suppressor protein 1 (FSP1) is a newly identified suppressor for ferroptosis. This study aims to investigate the role of FSP1 in IDD. Nucleus pulposus (NP) tissues in humans were collected and NP cells from rats
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Post-transcriptional regulation of DEAD-Box RNA helicases in hematopoietic malignancies Genes Dis. (IF 6.8) Pub Date : 2024-02-28 Jiankun Fan, Zhigang Li, Li Pei, Yu Hou
Hematopoiesis represents a meticulously regulated and dynamic biological process. Genetic aberrations affecting blood cells, induced by various factors, frequently give rise to hematological tumors. These instances are often accompanied by a multitude of abnormal post-transcriptional regulatory events, including RNA alternative splicing, RNA localization, RNA degradation, and storage. Notably, post-transcriptional
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Development of novel osteoarthritis therapy by targeting AMPK-β-catenin-Runx2 signaling Genes Dis. (IF 6.8) Pub Date : 2024-02-24 Daofu Zeng, Muhammad Umar, Zhenglin Zhu, Haobo Pan, William W. Lu, Guozhi Xiao, Yan Chen, Liping Tong, Di Chen
Osteoarthritis (OA) is a debilitating chronic joint disease affecting large populations of patients, especially the elderly. The pathological mechanisms of OA are currently unknown. Multiple risk factors are involved in OA development. Among these risk factors, alterations of mechanical loading in the joint leading to changes in biological signaling pathways have been known as a key event in OA development
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Inhibition of sphingosine 1-phosphate receptor 3 ameliorates bleomycin-induced pulmonary fibrosis by suppressing macrophage M2 polarization Genes Dis. (IF 6.8) Pub Date : 2024-02-15 Huijun Qiu, Jiang Liu, Jingyi You, Ou Zhou, Chang Hao, Yi Shu, Deyu Ma, Wenjing Zou, Linghuan Zhang, Enmei Liu, Zhengxiu Luo, Luo Ren, Gang Geng, Lin Zou, Danyi Peng, Zhou Fu
Pulmonary fibrosis is a devastating lung disease without effective treatment options. Sphingosine-1-phosphate receptor 3 (S1pr3), a receptor for the lipid signaling molecule sphingosine-1-phosphate, has been shown to mediate the development of pulmonary fibrosis, although the underlying mechanism is not fully understood. Here, we found increased expression of S1pr3 in the lung during the process of
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Establishment of a mouse model of respiratory mycoplasma challenged intranasally combined intraperitoneally eliciting chronic inflammation and lung consolidation Genes Dis. (IF 6.8) Pub Date : 2024-02-09 Xing Xie, Yuan Gan, Maoda Pang, Lei Zhang, Fei Hao, Yanna Wei, Yi Chen, Rong Chen, Zhenzhen Zhang, Qingyun Xie, Daesub Song, Guoqing Shao, Maojun Liu, Qiyan Xiong, Zhixin Feng
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Chimeric RNA landscape in the placenta: A transcriptomic analysis revealing novel diagnostic biomarkers for preeclampsia Genes Dis. (IF 6.8) Pub Date : 2024-02-09 Jingjing Xu, Xinrui Shi, Shitong Lin, Sandeep Singh, Samuel Haddox, Christopher Phung, Tommy Manley, Ningxi Huang, Peng Wu, Hui Li
Chimeric RNAs, hybrid transcripts containing exons from two originally separate genes, have been extensively studied in various cancer types and non-cancerous tissues. The hybrid transcripts can arise through different mechanisms, such as chromosomal rearrangements, trans-splicing events, or read-through transcription. The investigation into chimeric RNA landscape across various cancer types as well