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UPLC-Q-TOF-MS Analysis of Chemical Constituents of the Kadsura coccinea Extract with Effect of Attenuating Lipid Accumulation in Vitro Nat. Prod. Commun. (IF 1.8) Pub Date : 2024-04-24 Tiancheng Gu, Wei Liu, Laiyou Wang, Jisheng Cheng
Objective/Background: This study aims to explore the Kadsura coccinea extract (KCE)'s effect on lipid accumulation in vitro and its chemical components characterizations, aiming at developing a new alternative plant medicinal resource to fight against non-alcoholic fatty liver disease (NAFLD). Methods: After toxicological evaluation of KCE on HepG2 cells, Oil red O staining model and intracellular
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Maqin Xiaoke Granule Alleviates Acute Bronchitis Induced by Smoking Combined With Streptococcus pneumoniae by Regulating NLRP3/p38 MAPK/Glycerophospholipid Pathway Nat. Prod. Commun. (IF 1.8) Pub Date : 2024-04-24 Wanxia Men, Ruipeng Liu, Min Yang, Yang Xu, Yanli Lei, Tao Liu
Objective: To explore the efficacy and mechanism of action of Maqin Xiaoke Granules (MQs) in the treatment of acute bronchitis (AB). Methods: The rat model of AB was established by mixed smoke and Streptococcus pneumoniae nasal infection. The pathological changes of lung tissue and bronchus were observed by hematoxylin-eosin (HE) staining and scored. The mRNA expression levels of NOD-like receptor
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Phytochemical and Pharmacological Review of the Genus Antidesma Nat. Prod. Commun. (IF 1.8) Pub Date : 2024-04-24 Hieu Nguyen-Ngoc, Thao Le-Thi-Phuong, Tuan Vu-Van, Tung Pham-Ha-Thanh, Tung Nguyen-Huu
BackgroundAntidesma is a large genus consisting of around 100 species, which are widely distributed in the tropics and subtropics of Asia, some species can be found in Africa, the Pacific islands, and Australia. The uses of Antidesma plants range from food (for juice, jam, and red wine production) to medicinal purposes (for treatment of indigestion, pneumonia, menstrual regulation, and osteoarthritis)
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Ocimum basilicum and Ocimum americanum: A Systematic Literature Review on Chemical Compositions and Antimicrobial Properties Nat. Prod. Commun. (IF 1.8) Pub Date : 2024-04-23 Shuma Fayera Wirtu, Ashutosh Kumar Mishra, Leta Tesfaye Jule, Krishnaraj Ramaswamy
ObjectivesThis systematic review aimed to evaluate the chemical compositions and Pharmacological applications of Ocimum basilicum, known as sweet basil, and Ocimum americanum, known as hoary basil, to assess their antimicrobial properties. Both plants are renowned for their culinary uses and medicinal properties, with studies suggesting potential therapeutic benefits due to their rich essential oil
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The Essential Oils of Wyethia Species: Wyethia Amplexicaulis (Nutt.) Nutt. and Wyethia Helianthoides Nutt. Nat. Prod. Commun. (IF 1.8) Pub Date : 2024-04-22 Kathy Swor, Prabodh Satyal, Ambika Poudel, William N. Setzer
Background/Objective: Wyethia amplexicaulis (shiny mule's ears) and Wyethia helianthoides (white-head mule's ears) are conspicuous forbs growing in open hillsides and prairies at mid to upper elevations in the Intermountain West region of the United States. There have been no previous reports on the essential oil compositions of any Wyethia species, so the objective of this study is to examine the
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Anthocyanins from Lycium ruthenicum Murray Prevent High-Fat Diet-Induced Obesity in Female Mice via Gut Microbiota-Related Bile Acids Metabolism Nat. Prod. Commun. (IF 1.8) Pub Date : 2024-04-22 Hui Li, Meng Zhang, Tingting Tan, Shiying Li, Jia Mi, Lu Lu, Yamei Yan, Linwu Ran
ObjectivesFemale obesity may be improved by the consumption of a high-polyphenolic-rich diet. Lycium ruthenicum Murray is a renowned edible plant, the fruit of which is abundant in anthocyanins and exhibits many biological activities. This study aimed to investigate the potential impact of anthocyanins derived from Lycium ruthenicum Murray (ACN) intervention on improving obesity by regulating the gut
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Modified Haoqin Qingdan Decoction Exerts Antioxidant Effect via Activating PI3K/Akt/Nrf2 Pathway on Allergic Asthma Mice Nat. Prod. Commun. (IF 1.8) Pub Date : 2024-04-17 Xiaojun Dong, Qi Zhang, Juan Gu, Mingxing Cai, Yuan Gan, Yanni Ye, Xun Yang, Dou Ding, Xiuwen Xia
ObjectiveThe aim of this study was to investigate the antioxidant effect and potential mechanism of Modified Haoqin Qingdan Decoction on ovalbumin (OVA)-induced allergic asthma (AA) mice.MethodsThe AA model of mice was induced by OVA combined with aluminum hydroxide. Resistance Index (RI) in airway was analyzed by AniRes2005 animal pulmonary function analyzer. H&E staining was used to evaluate the
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Mechanism and Experimental Verification of Rhodiola rosea L. for the Treatment of Acute Lung Injury Through Network Pharmacology and Molecular Docking Nat. Prod. Commun. (IF 1.8) Pub Date : 2024-04-17 Min Zhao, Guanping Lv, Xi Huang, Yong Niu, Qunhui Zhang, Wenhua Li
Objective: This article endeavors to dissect the bioactive elements, pharmacological effects, and potential mechanisms of Rhodiola rosea L. (RL) concerning acute lung injury (ALI) using a combined approach of network pharmacology and subsequent in vivo experimental validation. Methods: RL constituents and associated targets were retrieved from the Organchem database and pertinent articles. ALI-related
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Bioinformatic Analysis and in Vitro Experimental Verification of the Intervention Effect of Shipi-Xiaoji Recipe on the Progression of non-Alcoholic Fatty Liver Disease to Liver Cancer Nat. Prod. Commun. (IF 1.8) Pub Date : 2024-04-17 Jingting Zhang, Hongyao Chen, Kexiong Li, Wei Peng, Renyi Yang, Puhua Zeng
ObjectiveThis study aimed to screen and identify central genes associated with the progression of non-alcoholic fatty liver disease (NAFLD) to hepatocellular carcinoma (HCC), to establish prognostic and clinical prediction models based on the expression of these genes, and to evaluate the intervention of a traditional Chinese medicine (TCM) formula—SPXJF—on the development of NAFLD into HCC through
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Study on the Protective Effect of Flavonoids in Vernonia anthelmintica (L.) Willd on Oxidative Stress Damage of HaCaT Cells Nat. Prod. Commun. (IF 1.8) Pub Date : 2024-04-16 Guliqiehere Eibulayin, Nurgul Rahman, Jian H Fu, Adila Turxuntayi
Background: Vitiligo, a prevalent hypopigmented skin disorder, profoundly impacts patients’ psychological well-being and quality of life. Therefore, the development of more efficacious antivitiligo drugs is imperative. Objectives: The aim of this study was to investigate the protective effects of four flavonoids found in Vernonia anthelmintica (L.) Willd such as Butin, Butein, Eriodictyol, and Liquiritigenin—against
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Phytochemical Composition and Cytotoxic Activity of Senecio asirensis Hexane Fraction Using In Vitro and In Silico Approaches Nat. Prod. Commun. (IF 1.8) Pub Date : 2024-04-13 Omkulthom Al kamaly, Hamada Imtara, Ashwag S. Alanazi, Omar Noman
ObjectiveSenecio asirensis, an endemic species of Saudi Arabia, has been traditionally used to treat various ailments. The present study aimed to investigate the phytochemical composition, antimicrobial activity, and cytotoxic potential of Senecio asirensis fractions, and to identify the main compounds in the extract that are the most active.MethodsThe antimicrobial activity was evaluated using disc
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Biofilm Disruption and Virulence Attenuation Effects of Essential Oil From Endemic Algerian Cistus munbyi (Cistaceae) Against Clinical Strains of Pseudomonas aeruginosa Nat. Prod. Commun. (IF 1.8) Pub Date : 2024-04-13 Asma Benaissa, Abdelmounaim Khadir, Alfred Ngenge Tamfu, Selcuk Kucukaydin, Nawel Latti, Fethi Benbelaïd, Sameh Boudiba, Busra Eroglu, Mourad Bendahou, Ozgur Ceylan
Background: Pseudomonas aeruginosa is an opportunistic, resistant and highly pathogenic bacteria, responsible for severe nosocomial infections in humans. There is need to search new antimicrobials to target P. aeruginosa strains. Cistus munbyi is used in traditional medicine to manage infections. Objectives: This work aims to investigate the antimicrobial, antibiofilm and other antivirulence effects
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Network Pharmacology and In Vivo Validation to Explore the Potential Active Ingredients and Mechanisms of Ziyin Buyang Formula in Diminished Ovarian Reserve Nat. Prod. Commun. (IF 1.8) Pub Date : 2024-04-04 Ruxin Wang, Haixia Huang, Wenchen Du, Guicheng Xia, Yong Tan
The incidence rate of diminished ovarian reserve (DOR) is increasing, which is a difficult problem in the field of reproductive biology. The Ziyin Buyang Formula (ZYBYF), an empirical prescription for traditional Chinese medicine, is often used to improve the ovarian function of women with DOR. However, the underlying mechanism of this phenomenon remains unclear. This study was designed to identify
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Quantum Tunneling in Natural Product Biosynthesis Nat. Prod. Commun. (IF 1.8) Pub Date : 2024-04-04 Crist N. Filer
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Multitarget Mechanism of Artemisia Plants to Fight Respiratory Tract Infections Based on Network Pharmacology and Molecular Docking Nat. Prod. Commun. (IF 1.8) Pub Date : 2024-04-04 Zhao-zhen Xu, Zhi-xin Sun, Farukh-S Sharopov, William-N Setzer, Yan-fang Sun
Objective: To study the mechanism of Artemisia in the treatment of respiratory tract infection (RTI) by network pharmacology and molecular docking. Methods: The active constituents and targets of Artemisia were screened by the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform (TCMSP). Gene Cards database to obtain disease targets associated with RTI. The key targets of
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Macleaya cordata Extract Inhibits LPS-Induced IPEC-J2 Inflammation Through TLR4-Mediated NF-κB and MAPK Signaling Pathways Nat. Prod. Commun. (IF 1.8) Pub Date : 2024-04-04 Diangang Han, Hongqing Yang, Litao Che, Chong Zhang, Jing Li, Lingling Ye, Chunyong Zhang, Rongfu Guo, Jige Xin
Objectives: The Macleaya cordata has long been utilized as a traditional medicinal remedy for treating inflammation in certain countries, and it is also being considered as a potential alternative to antibiotic growth promoters in livestock breeding. However, the molecular mechanisms underlying its anti-inflammatory characteristics have not been thoroughly investigated. In this study, we assessed the
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Valorization of the Sabinas Forest Waste (Juniperus phoenicea and Juniperus thurifera) as Source of Biopesticides Nat. Prod. Commun. (IF 1.8) Pub Date : 2024-04-03 Alberto Galisteo, Houda Zaher, Jorge R. Lopez-Menchero, Azucena Gonzalez-Coloma, Maria Fe de Andres, José F. Quílez del Moral, Alejandro F. Barrero
Objectives: The potential forestry use of Juniperus phoenicea and Juniperus thurifera pruning woods is studied by analyzing the composition of the woods and testing the biological activities of the corresponding components with the ultimate target of finding new biopesticides. Methods: The air-dried wood from each plant was crushed and subjected to hydrodistillation, and the residue was extracted with
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Andrographis paniculata Leaves Extract Alleviates UVB-Induced HaCaT Cells Through Suppressing Mitogen-Activated Protein Kinases Activation Nat. Prod. Commun. (IF 1.8) Pub Date : 2024-04-03 Al Borhan Bayazid, Ue Kyoung Hwang, Young Ah Jang, Yeong Hwan Jeong, Yu Chang Jo, Beong Ou Lim
ObjectivesAndrographis paniculata leaves have been widely used in traditional medicine due to their rich content of phenolic compounds. We sought to figure out the skin beneficial effects of Andrographis paniculata leaves extract.MethodsIn this study, we evaluated the total phenolic and flavonoid content of Andrographis paniculata leaf extracts (ALE), as well as its antioxidant activities against
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A Comprehensive Metabolite Profile of Green and White Asparagus (Asparagus officinalis L.) and Their Antioxidant Properties in Differing Cultivation Conditions Nat. Prod. Commun. (IF 1.8) Pub Date : 2024-04-03 Tae Jin Kim, Young Jin Park, Tae Gyu Yi, Woo Duck Seo, Nam Il Park, Jae Kwang Kim
Asparagus ( Asparagus officinalis L.) is a food crop with a variety of pharmacological effects that can be classified as green or white, depending on cultivation methods. However, no research has been conducted on the profiles of primary and secondary metabolites in green and white asparagus. Hence, the aim of this study was to comprehensively analyze and understand the metabolic variations associated
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In Vitro Analysis of Antimalarial Activity of Achillea fragrantissima (Forssk.) Sch.Bip Extracts Based on Beta-Hematin Formation Nat. Prod. Commun. (IF 1.8) Pub Date : 2024-04-02 Fuad Al-Rimawi, Mutaz Akkawi, Hadba Tarayrah, Osama Abu-Yabes, Qasem Abu-Remeleh, Hadiah Almutairi, Abdulrahman Almutairi, Bushra Riaz, Sulaiman Mohammed Alnasser, Mazahir Sanosi, Nimer Fehaid Alsabeelah, Fadel Wedian, Mohammed Ail Assiri, Haya Ayyal Salman, Ghassab M. Al-Mazaideh
Introduction: The use of medicinal plants from traditional knowledge systems has increased in recent years. Achillea fragrantissima-infused water has a historical use in relieving gastrointestinal complaints and treating skin inflammations. With the rising resistance to antimalarial drugs, finding safe and affordable new drugs is crucial. Exploring medicinal plants shows promise for drug development
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16S rRNA Gene-Based Microbiome Taxonomic Profiling for Evaluating the Effect of Mumefural on Fecal Microbiota in C57BL/6 Mice Nat. Prod. Commun. (IF 1.8) Pub Date : 2024-03-29 Jungim Kim, Min-Soo Kim, Won Kyung Jeon
ObjectivesBased on a report that Prunus mume fruits affect gut function and microflora, we hypothesized that mumefural (MF), one of the active compounds of processed Prunus mume fruits, could affect intestinal function or gut microbiome.Methodswe investigated the effects of orally administered MF on intestinal function and the intestinal environment by analyzing the changes in the fecal, intestinal
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Chemical Profile and Assessment of Antioxidant, Anti-Inflammatory, and Antiproliferative Effects of Ammodaucus leucotrichus Coss. & Dur. Fruit Extracts on Human Breast Cancer Nat. Prod. Commun. (IF 1.8) Pub Date : 2024-03-29 Fatima Zohra Belbachir, Lamia Hamdan Ramdani, Caroline Decombat, Mael Gainche, Pierre Chalard, Nassim Djabbou, Nadia Taibi, Khaldoun Bachari, Kamel Dali Yahia, Laetitia Delort, Florence Caldefie-Chezet
ObjectiveIn this study, we analyzed and investigated the antioxidant, anti-inflammatory, and antitumoral properties of methanolic (Met), dichloromethane (Dic), ethyl acetate (Ac), and diethyl ether (Et) fruit extracts of Ammodaucus leucotrichus on the MCF-7 breast cancer cell line.MethodsThe extracts of Ammodaucus leucotrichus fruits, explored in this study, were obtained by cold maceration and analyzed
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Investigation of the Mechanism of Action of Qingzaojiufei Decoction on Idiopathic Pulmonary Fibrosis Based on Network Pharmacology and Experimental Validation Nat. Prod. Commun. (IF 1.8) Pub Date : 2024-03-29 Chunyang Mao, Yan Du, Kun Niu, Fan Yang, Changcai Bai, Bo Zhou, Yang Niu
Objective: The Traditional Chinese Medicine Qingzao Jiufei Tang decoction (QZJFD) is effective for the treatment of idiopathic pulmonary fibrosis (IPF). In this study, we explored the anti-pulmonary fibrosis effect of QZJFD and the underlying mechanism. Methods: The effects of QZJFD at low, medium, and high doses were investigated in a rat model of lung fibrosis induced by tracheal injection of bleomycin;
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Expression Analysis of Phenylpropanoid Pathway Genes and Phenylpropanoid Accumulation in Different Organs of Chelidonium majus L. Nat. Prod. Commun. (IF 1.8) Pub Date : 2024-03-27 Haejin Kwon, Ramaraj Sathasivam, Jiwon Yoon, Chanung Park, Nam Il Park, Yong Suk Chung, Sang Un Park
ObjectiveThis study set out to examine the phenylpropanoid pathway gene expression and phenolic compound accumulation in different organs of Chelidonium majus (C. majus).MethodsTotal RNA was extracted and expression of phenylpropanoid biosynthesis genes was assessed using quantitative real-time polymerase chain reaction in different organs of C. majus. In addition, the phenylpropanoid compounds were
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Marine-Derived Bioactive Proteins and Peptides: A Review of Current Knowledge on Anticancer Potentials, Clinical Trials, and Future Prospects Nat. Prod. Commun. (IF 1.8) Pub Date : 2024-03-27 Emmanuel Sunday Okeke, Innocent Uzochukwu Okagu, Kingsley Chukwudozie, Tobechukwu Christian Ezike, Timothy Prince Chidike Ezeorba
The rise in cancer cases has prompted searching for novel and alternative sources of natural bioactive compounds with antitumor potential. Nearly three-quarters of our planet is covered by the ocean, the habitat of numerous prokaryotic and eukaryotic organisms and sustainable alternative nutrient sources. The marine ecosystem is a rich reservoir of proteins and novel bioactive peptides with diverse
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Chemical Composition, Antimicrobial and Antioxidant Properties of Essential Oil From the Leaves of Vernonia volkameriifolia DC. Nat. Prod. Commun. (IF 1.8) Pub Date : 2024-03-27 Bui B. Thinh, Dau B. Thin, Isiaka A. Ogunwande
ObjectivesThe objective of this study was to investigate the essential oil (EO) extracted from the leaves of Vernonia volkameriifolia DC., a Vietnamese plant belonging to the Asteraceae family. The focus was on determining the chemical composition of the EO and assessing its antimicrobial and antioxidant activities.MethodsThe EO obtained from V. volkameriifolia underwent comprehensive analysis using
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Establishment of CME Mouse Model Based on Autologous Thrombotic Particles and the Effect of Shexiang Tongxin Dropping Pill on the Coronary Microvascular Blood Flow in This Model Nat. Prod. Commun. (IF 1.8) Pub Date : 2024-03-25 Xiaojun Li, Dong Deng, Yiming Yang, Yan Li, Lan Chen, Wei Wang, Yijun Chen
Coronary microvascular disease poses significant clinical harm and is closely associated with major cardiovascular adverse events. Existing research has highlighted coronary microvascular embolism (CME) as an important factor. Previous studies have utilized microspheres to construct a mouse model of CME, which can partially simulate coronary microvascular disease. However, there are notable discrepancies
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Exploring the Mechanisms of the Huangqin Qingfei Decoction in Pneumonia Treatment for Lipopolysaccharide-Induced Mouse Model: A Network Pharmacology Analysis and Experimental Validation Nat. Prod. Commun. (IF 1.8) Pub Date : 2024-03-22 Zengle Zheng, Jingyun Lei, Jia Chang, Xiuxiu Yi, Guoying Zhou, Jing Chen
Objective: In this study, a network pharmacological approach, and in vivo validation experiments were used to screen the active components of the Huangqin Qingfei decoction (HQFD) for their therapeutic efficacy in pneumonia. Methods: The active ingredients and targets of the HQFD were retrieved from the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform, while pneumonia-related
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Ab Initio Conformational Analysis of 3,7-Diacetyl-3,7-Diazabicyclo[3.3.1]Nonanes Nat. Prod. Commun. (IF 1.8) Pub Date : 2024-03-22 Sergey A. Pisarev, Elena A. Golubeva, Vladimir A. Palyulin
Introduction: The importance of the conformational behavior comprehension for proper prediction of properties for a certain compound or for a class of compounds is indisputable. For 3,7-diacylbispidines (3,7-diacyl-3,7-diazabicyclo[3.3.1]nonanes), only “double chair” (CC) conformers were prior found experimentally in the condensed phase, which differ only in the acyl groups relative orientation, “parallel
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Network Pharmacology Approach and Partial Experimental Validation of Aidi Injection Solution for the Treatment of Colorectal Cancer Nat. Prod. Commun. (IF 1.8) Pub Date : 2024-03-22 Wentao Yu, Yinhua Weng, Jiawei Wang, Yifei Gao, Yaqi Li, Chichu Xie, Zhiyuan Jian
PurposeThe objective of this research was to employ network pharmacology to analyze and identify the key active components and target points of action of Aidi injection in relation to colorectal cancer. Additionally, this study aimed to experimentally validate the mechanism of action of hinokinin in treating colorectal cancer.MethodsThis study employed a network pharmacology methodology to identify
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Jingfang Granules May Improve Early Pancreatic Cancer by Modulating Immune Response Through RUNX3 Nat. Prod. Commun. (IF 1.8) Pub Date : 2024-03-22 Weiping Ge, Yuting Li, Sina Pan, Fenghui Ma, Min Li, Lei Yan, Xue Meng, Huiying Ma, Guangyan Li, Jingchun Yao, Tao Li
Objective: Jingfang granule (JFG) is a modified formulation of Jingfang Baidu Power for the treatment of influenza and infectious diseases. Recent studies show that JFG may inhibit the development of cancer but the effect of JFG on methylation in early pancreatic cancer has remained unclear. In this study, we aim to investigate the potential effect of JFG on gene methylation of early pancreatic cancer
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Studies on Differentially Expressed Genes of Tetrastigma hemsleyanum and Its Antitumor Activity Nat. Prod. Commun. (IF 1.8) Pub Date : 2024-03-22 Guanping Chen, Jing Li, Yingyan Lu, Jili Cao, Liqin Lai
Objective: To analyze highly expressed genes in Tetrastigma hemsleyanum roots and the in vitro antitumor effects of extracts from different parts of this plant. Methods: The expression profiles of the roots, stems, and leaves of T hemsleyanum were analyzed via high-throughput sequencing technology with the Illumina Genome Analyzer platform. Then, gene ontology (GO) functional and pathway enrichment
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Redefining the Therapeutic Landscape: A Critical Analysis of Triterpenoids as Neutrophil Elastase Inhibitors Nat. Prod. Commun. (IF 1.8) Pub Date : 2024-03-22 George Oche Ambrose
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Pharmacological Mechanisms of Periplocae Cortex Against Congestive Heart Failure Based on Network Pharmacology and Experimental Evaluation Nat. Prod. Commun. (IF 1.8) Pub Date : 2024-03-20 Xiaojing Zhang, Zhijie Liu, Baojian Guo, Qingbin Cui, Jun Gao, Zhanfang Kang, Guanghui Xiao
BackgroundPeriplocae cortex is a well-known Traditional Chinese Medicine with abundant effects, including the treatment of chronic congestive heart failure (CHF). However, the principal components and mechanisms have not been fully elucidated. This study aims to analyze the active ingredients and potential mechanisms of the periplocae cortex in CHF treatment.MethodsTCMSP, GeneCards, and Comparative
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Trillin Protects Against Bleomycin-Induced Pulmonary Fibrosis via Suppressing Oxidative Stress and IL-1β/NLRP3 Inflammasome Positive Cycle Nat. Prod. Commun. (IF 1.8) Pub Date : 2024-03-15 Xiangyun Li, Shanshan Wei, Sa Liu, Suifen Xie, Jiaqin Liu, Yuanying Yang, Ye Chen, BiKui Zhang, Wenqun Li, Fen Luo
BackgroundIdiopathic pulmonary fibrosis (IPF) is a chronic, progressive, and fibrotic interstitial lung disease. Trillin, an active saponin component isolated from Trillium tschonoskii Maxim, exhibits various pharmacological properties. This study aimed to investigate the preventive effects of Trillin on bleomycin (BLM)-induced IPF and elucidate its underlying mechanisms.MethodsBLM was administered
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Morphology and Cyto-Architecture of the Testis and Assessment of Selected Biochemical Parameters Associated with Male Fertility Following the Consumption of Tom Brown Weaning Diet in Albino Wistar Rats Nat. Prod. Commun. (IF 1.8) Pub Date : 2024-03-15 Victor Kanu Uno, Justina Nwandimma Nwangwa, Ekementeabasi Aniebo Umoh, Atim-Ebim Michael Raymond, Joseph Okon Asuquo, Effiom-ekaha Otu Otu, Maxwell Inawerebua Beniangba
Objectives/BackgroundNatural products are preferred over synthetic drug as fertility enhancers as they are cost effective. Infertility among men of reproductive age keeps rising. Synthetic drugs ameliorate the problem but leave adverse side effects as men advance in age, hence the need for alternative medicine. Tom brown weaning diet is a processed cereal-based powdery blend which is cooked into a
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Tripterygium Glycosides in the Treatment of Asthma: Integrating Network Pharmacology, Molecular Docking and In Vitro Preliminary Pharmacological Evaluation Nat. Prod. Commun. (IF 1.8) Pub Date : 2024-03-15 Shuhui Gao, Min Yan, Tianci Jiang, Jingyao Lian, Zhe Cheng, Huahui Zeng, Junwei Zhao
ObjectivesThe mechanism of tripterygium glycosides (TG) in the treatment of asthma was explored by utilizing network pharmacology, molecular docking, and in vitro preliminary pharmacological tests.MethodsAn analysis of the bioactive ingredients of TG was conducted using the Traditional Chinese Medicine Systems Pharmacology Database database or predicted by FAFdrugs4, with relevant targets gathered
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Uncovering the Nephroprotective Mechanism of Caffeic Acid in Renal Tubulointerstitial Fibrosis through Network Pharmacology Analysis Nat. Prod. Commun. (IF 1.8) Pub Date : 2024-03-13 Wenbo Sun, Haojie Liu, Baoqiao Wu, Limiao Dai, Yan Ren, Danna Zheng
Background: Renal tubulointerstitial fibrosis (RTF) is a progressive kidney condition characterized by the formation of fibrotic tissue. Caffeic acid (CA), a key component of the medicinal plant Antirhea borbonica, shows promise as a potential treatment for renal fibrosis. Here, we investigated the nephroprotective effect of CA in RTF and its underlying mechanisms. Methods: RTF was induced in rats
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Integrated UHPLC-Q-Orbitrap-MS/MS Method and Network Pharmacology for Exploring the Active Components and Potential Mechanisms of Neuroprotective Effect of the n-Butanol Part of Mume Flos Nat. Prod. Commun. (IF 1.8) Pub Date : 2024-03-10 Xue Wang, Hongsu Zhao, Mengying Wu, Yijie Gan, Shurong Zhang, Deling Wu, Jinmei Ou, Chuanshan Jin, Wei Zhang
Background: Mume Flos is a common Qi-regulating medication used in traditional Chinese medicine, modern study has discovered that Mume Flos and its components have neuroprotective properties. However, the effective components and molecular mechanisms of Mume Flos are still unclear. Methods: In this study, the current study chose Caenorhabditis elegans as a model to evaluate the anti-Alzheimer disease
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Mechanism for Huanglian Jiedu Decoction-Based Therapy for MAFLD Analyzed Through Network Pharmacology and Experimental Verification Nat. Prod. Commun. (IF 1.8) Pub Date : 2024-03-08 Jixian Zheng, Anni Zheng, Sufei Song, Mengyu Lin, Tao Liu, Qiuling Xu
Objective: To analyze the mechanism of Huanglian Jiedu Decoction (HLJDD) in the treatment of metabolism-associated fatty liver disease (MAFLD). Methods: The main components, targets, and pathways for treating MAFLD of HLJDD were screened through network pharmacology and molecular docking validation was done; HLJDD was used to intervene MAFLD model of rat, the levels of ALT, AST, TC, TG, GLU, HDL, and
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Mechanism of Action of Yikun Yitong Ping-Containing Serum on Mast Cells and its Possible Involvement in Endometriosis-Related Dysmenorrhea Nat. Prod. Commun. (IF 1.8) Pub Date : 2024-02-28 Fang Yang, Yonghui Yu, Hong Liu
BackgroundPreviously, we showed that Yikun Yitong Ping (YKYTP) can effectively and safely relieve endometriosis-related dysmenorrhea; however, the underlying mechanism remained unclear. This study aimed to assess the effects of YKYTP-containing serum on rat basophilic leukemia cell line, as mast cells (MCs) analog, and investigate the mechanisms by which YKYTP alleviates endometriosis-related dysmenorrhea
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Multifunctional Analysis of Banana Leaves Extracts for Dyeing Properties of Pima Cotton Fabric Using Different Mordants Nat. Prod. Commun. (IF 1.8) Pub Date : 2024-02-26 Qurat ul Ain, Zill-i-Huma Nazli, Maryam Aslam, Imran Zafar, Hassan Imran Afridi, Ahsanullah Unar, Muhammad Jamshaid, Rizwan- ur-Rehman, Waseem Shoukat, Hanane Mouada, Fakhreldeen Dabiellil, Mohammed Bourhia, Abdulaziz Abdullah Alsahli
IntroductionNatural dyes have become very important for decades based on their extensive properties compared to synthetic dyes. Pima cotton was dyed with natural dyes derived from plants using mordants, a crucial step in modern industry.ObjectiveThis study explores the efficacy of banana leaf-extracted natural dyes with mordants in dyeing Pima cotton, examining color properties, chemical attributes
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Ethnomedicinal, Phytochemical, and Pharmacological Properties of Diospyros mollis Griff.: A Review Nat. Prod. Commun. (IF 1.8) Pub Date : 2024-02-26 Tran Van Chen, Nguyen Trong Nghia, Le Van Nhat Truong, Nguyen Hoang Khanh Linh
Objective/BackgroundThe genus Diospyros L. (Ebenaceae) includes about 778 species worldwide, with over 500 of them known for their significant health benefits. Among them, Diospyros mollis Griff. has been used as a tonic and treatment for many diseases related to digestive disorders and intestinal parasites. Furthermore, the fruit has also been used for dyeing silk fabrics. The purpose of this comprehensive
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Isolation and Identification of Anti-Inflammatory Active Components from Asparagi Radix cochinchinensis Based on HPLC-CAD and UPLC-Q/TOF-MS Techniques Nat. Prod. Commun. (IF 1.8) Pub Date : 2024-02-26 Yan Lei, Bing Wang, Guanglin Zhu, Guo Feng, Wei Li, Caiyao Han, Qian Qin, Xie-an Yu, Xueli Song, Zhengyan He, Ju Zhang, Hongmei Su, Wenjing Wang
Background: In the research of the pharmacological activity of modern Chinese medicine, a large number of traditional Chinese medicines show anti-inflammatory activity. Asparagi radix is one of the anti-inflammatory drugs. With the deepening of people's research on Asparagi radix, its anti-inflammatory pharmacological effects have been gradually explored, but its specific anti-inflammatory active ingredients
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Evaluation of Saudi Juniperus procera Extracts Cytotoxicity and Regulatory Mechanisms of Tumorigenesis Against Two Breast Cancer Cell Lines Nat. Prod. Commun. (IF 1.8) Pub Date : 2024-02-23 Ateeq A. Al-Zahrani, Farag Ibraheem, Mohamed El-Hefny, Fardous El-Senduny
BackgroundBreast cancer poses a major threat to female health worldwide. One of the medicinal plants used in traditional Saudi medicine is the Juniperus procera (Arar) plant, which is used to cure various illnesses, including cancer.ObjectivesThe cytotoxic properties of Saudi J. procera extracts and their regulatory mechanisms against tumorigenesis in breast cancer were investigated.MethodsThe antioxidant
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Seasonal Variations in the Essential Oil Composition and Biological Activities of Wild Lavandula dentata L. Nat. Prod. Commun. (IF 1.8) Pub Date : 2024-02-21 Amina Labhar, Yahya El-Mernissi, Naoufal Ahidar, Aziz Zouhri, Omar Benamari, Farhan Siddique, Maryam Bashir, Amin Salhi, Mhamed Ahari, Samir Ibenmoussa, Mohammed Bourhia, Ahmad Mohammad Salamatullah, Abdellah ELyoussfi, Hassan Amhamdi
Introduction: Lavandula dentata L. (LD) is a well-known aromatic and medicinal plant celebrated for its abundant essential oil (EO) with applications in aromatherapy, perfumery, and traditional medicine. The chemical composition and biological properties of LD EO can vary based on factors like harvesting period, and cultivation location. Methods: Gas chromatography–mass spectrometry was employed to
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Effects of Inhaled Linalool on the Autonomic Nervous System in Awake Mice Nat. Prod. Commun. (IF 1.8) Pub Date : 2024-02-19 Tadaaki Satou, Momono Kamagata, Shinjiro Nakashima, Koushi Mori, Moeka Yoshinari
Objective/backgroundA previous study showed that geranium essential oil predominantly affects the parasympathetic nervous system. This article examined the effects on the autonomic nervous system of linalool, one of the main components of geranium essential oil.MethodsMice were placed on a narrow elevated open platform and pulse wave measurements were taken while they were awake, with behaviors restricted
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Study on the Chemical Composition and Blood-Entry Components of Nourishing Blood Diuretic Formula Based on Liquid Chromatography-Mass Spectrometry and Network Pharmacology Techniques Nat. Prod. Commun. (IF 1.8) Pub Date : 2024-02-15 Si-Cheng Yang, Xia Lei, Si-Fang Xie, Ju Huang, Feng-Qin Yue, Si-Di Chen, Wei Peng, Heng Fan, Sen Li, Xue-Yun Duan, Wan-Jin Sun
Objective: Analyzing the chemical composition and blood-entry components of Nourishing Blood Diuretic Formula (NBDF) by Liquid Chromatography-Mass Spectrometry (LC-MS), and analyzing the mechanism of NBDF in the treatment of chronic renal failure by combining network pharmacology and molecular docking technology. Methods: The prototype components were obtained by LC-MS, and the targets of the prototype
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Essential Oils of Two Species of Zingiberaceae Family from Vietnam: Chemical Compositions and α-Glucosidase, α-Amylase Inhibitory Effects Nat. Prod. Commun. (IF 1.8) Pub Date : 2024-02-14 Hieu Tran-Trung, Duc Giang Le, Van Trung Hoang, Danh C. Vu, Tran Dinh Thang, Hieu Nguyen-Ngoc, Chen Tran Van, Thanh Triet Nguyen, Nguyen Hoang Tuan, Trang H.D. Nguyen
The ginger family (Zingiberaceae) is one of the most diverse and abundant families in the plant kingdom in terms of number of species. In terms of chemistry, this is a family of plants containing much essential oil with mainly monoterpene and sesquiterpene derivatives, which has been widely used in medicine, food, and flavor industries. In our series of studies on ginger family plants, the two new
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The Dynamics of Bioactive Ingredients With Anti-Inflammatory and Anti-Breast Cancer Activity During Prunellae Spica Development Nat. Prod. Commun. (IF 1.8) Pub Date : 2024-02-13 Zhimin Zhang, Qian Su, Yan Lin, Bohou Xia, Yamei Li, Jingchen Xie, Ping Wu, Duanfang Liao, Limei Lin
To investigate the scientific connotation of harvest period for Prunella vulgaris L. ( P vulgaris, known as Prunellae Spica), the triterpenoids and phenols of Prunellae Spica in developmental stages were quantified by high performance liquid chromatography, and the anti-inflammatory and anti-breast cancer properties of which were investigated. Furthermore, Grey correlation and Pearson correlation analysis
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Antibacterial Activity and Possibly Made of Action of Isoquinoline-3-Carboxylic Acid Nat. Prod. Commun. (IF 1.8) Pub Date : 2024-02-09 Xu Zhiyuan, Ding Haixin, Fu Xin, Xu Yan, Zhu Fadi, Ye Huochun, Zhang Yuan Yuan, Guo Yongxia, Zhang Jing, Feng Gang
ObjectivesDue to the urgent need to develop innovative, environmentally sustainable bactericides, we use the natural product isoquinoline as a lead compound to discover highly active bactericides from isoquinoline derivatives.MethodsIn this paper, the antibacterial activity of 49 isoquinoline derivatives was evaluated against three plant bacteria in vitro.ResultsAmong all the derivatives, isoquinoline-3-carboxylic
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Curcumin Delivery Systems: How Far from Clinical Application in Tumor Therapy? Nat. Prod. Commun. (IF 1.8) Pub Date : 2024-02-07 Yuanru Wang, Lubiao Liang, Yajin Zhao
Curcumin, a natural polyphenol compound found in turmeric, exhibits significant anti-cancer activity in preclinical studies. However, its clinical application is limited by poor bioavailability and low solubility in aqueous media. To overcome these challenges, various curcumin delivery systems (CDSs) have been developed to enhance the pharmacokinetics and pharmacodynamics of curcumin, aiming to improve
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Preparation, Characterization, and Sub-Chronic Toxicity of Carvacrol-Self-Nano-Emulsifying Drug Delivery System Towards Healthy Sprague Dawley Rats Nat. Prod. Commun. (IF 1.8) Pub Date : 2024-02-07 Fenk Bakir Maarouf, Heshu Sulaiman Rahman
Background: Carvacrol (CAR) is the active component in essential oils (EOs) of many fragrant plants, including oregano and thyme; however, its high toxicity restricts its usage in biomedical fields, and the self-nano-emulsifying drug delivery system (SNEDDS) was suggested to overcome this issue. Objective: To prepare and characterize the CAR-loaded SNEDDS and to assess its toxicity profile towards
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Momordin Ic Inhibits the Partially Malignant Phenotype of Osteosarcoma Cells by Inducing Apoptosis and Autophagy Nat. Prod. Commun. (IF 1.8) Pub Date : 2024-02-07 Ruiqing Xu, Rui Huang, Jiandang Shi, Dawei Chu, Pengyu Yang
ObjectivesStudies have shown that Momordin Ic (MI) has an antitumor effect on liver cancer, gastric cancer, and colorectal cancer. However, its effect on osteosarcoma has not yet been reported. The purpose of this study was to explore the effect of MI on several malignant phenotypes of osteosarcoma cells.MethodsCCK-8 and EdU were used to evaluate the effect of MI on the proliferation of osteosarcoma
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Pachymic Acid Alleviates Oxidative Damage of Retinal Cells Induced by Sodium Iodate or Hydrogen Peroxide by Activating the Nrf2/HO-1 Signaling Pathway Nat. Prod. Commun. (IF 1.8) Pub Date : 2024-01-31 Chengyao Qin, Xi Chen, Tianming Hu, Wenxiu Sun, Zehao Liu, Min Li, Yan Shao, Wei Wei
Background: Pachymic acid (PA), extracted from the traditional Chinese medicinal herb Poria cocos ( P cocos) is reported to protect organs such as the liver and lungs from damage. This study investigated the effect of PA on oxidative stress in the retina in vivo and in vitro. Methods: In vitro, retinal pigment epithelial (RPE) cells were treated with hydrogen peroxide to establish a cell model of oxidative
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Stability of Piceatannol in Dulbecco's Modified Eagle's Medium by In Situ UPLC-MS/MS Analysis Nat. Prod. Commun. (IF 1.8) Pub Date : 2024-01-24 Meng S. Cheong, Lutfun Nahar, Satyajit D. Sarker, Hui Cao, Wai S. Cheang, Jianbo Xiao
Piceatannol is a stilbenoid, which has shown bioactivities in various cell culture models. However, its stability in cell culture medium is not clear. Here, UPLC-MS/MS was applied in situ to analyze the degradation products of piceatannol in Dulbecco's Modified Eagle's Medium (DMEM) and cell culture to investigate the compound's stability in DMEM. During the incubation with cell culture medium (at
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Potential of 2-Hydroxyacetophenone Derivatives and Simple Phenol's for the control of Meloidogyne javanica Nat. Prod. Commun. (IF 1.8) Pub Date : 2024-01-24 Luis Alberto González López, Maria Fe Andres, Wiston Quiñones, Fernando Echeverri, Azucena Gonzalez-Coloma
Objective: In this study, a series of synthetic hydroxylated (5-10) and prenylated (10-17) acetophenones, chalcones (18-20) and a flavone (21) have been synthesized and evaluated on the nematode Meloidogyne javanica. Additional phenolic compounds, including salicylic acid, isopropyl salicylate, thymol, carvacrol, cumic acid, eugenol, vanillin, and vanillic acid (22-29), were also tested. Methods: Compounds
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Adenophorae Radix Reduces Fibrosis in a Bleomycin-Induced Pulmonary Fibrosis Mouse Model Nat. Prod. Commun. (IF 1.8) Pub Date : 2024-01-24 Eui-Joong Kim, Jiwon Park, Chang-Hwan Yu, Jae-Woo Park, Kwan-Il Kim, Hee-Jae Jung, Jang-Hoon Kim, Youngmin Bu, Beom-Joon Lee
Background: A screening study investigated the effects of lung-moistening herbal medicines on a bleomycin-induced pulmonary fibrosis mouse model and reported that the efficacy of Adenophorae Radix (ADR) was higher than that of other remedies. Objectives: This study aimed to investigate the antifibrotic efficacy and mechanism of action of ADR in a mouse model of bleomycin-induced pulmonary fibrosis
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Study on the Active Components and Inhibiting Effect of Melastoma dodecandrum Lour. on Human Cervical Cancer Cells Based on Spectrum–Effect Relationship Analysis Nat. Prod. Commun. (IF 1.8) Pub Date : 2024-01-24 Song Qian, Zuhua Wang, Xiuping Ma, Huiyi Ming, Jing Liu, Jing Yang, Teng Chen, Linli Liu, Jibian Ban, Jiangtao Guo
BackgroundThe ethnic drug Melastoma dodecandrum Lour. (MDL) is an important medicinal plant with potential antitumor properties, which have been proposed as promising anticancer agents, but the material basis for its therapeutic effect is still unclear and lacks in-depth research.MethodsIn this study, the in vitro antitumor effects of different MDL extracts in different gynecological tumor cells were
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Exploring the Biomedical Potential of Endophytic Fungi Isolated from Panamanian Mangroves Nat. Prod. Commun. (IF 1.8) Pub Date : 2024-01-24 Lilia Cherigo, Dioxelis López, Carmenza Spadafora, Luis C. Mejia, Sergio Martínez-Luis
Objective: The objective of this study was to assess the biomedical potential of endophytic fungi isolated from Panamanian mangrove plants. This was achieved through the biological evaluation of organic extracts to determine their antiparasitic, anticancer, toxicity activity, and inhibition of the enzyme α-glucosidase. Methods: Leaves from various mangrove plant species in five different zones along