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Interactions of phenylalanine derivatives with human tyrosinase: lessons from experimental and theoretical studies ChemBioChem (IF 3.2) Pub Date : 2024-04-20 Clarisse Faure, Yi Ming Ng, Catherine Belle, Montserrat Soler-Lopez, Lyna Khettabi, Melissa Saidi, Nathalie Berthet, Marc Maresca, Christian Philouze, Walid Rachidi, Marius Reglier, Amaury du Moullinet d'Hardemare, Hélène Jamet
The pigmentation of the skin, modulated by different actors in melanogenesis, is mainly due to the melanins (protective pigments). In humans, these pigments’ precursors are synthetized by an enzyme known as tyrosinase (TyH). The regulation of the enzyme activity by specific modulators (inhibitors or activators) can offer a means to fight hypo- and hyper-pigmentations responsible for medical, psychological
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Lysosomal Peptide Self‐Assembly To Control Cell Behavior ChemBioChem (IF 3.2) Pub Date : 2024-04-25 Sangshuang Li, Huaimin Wang
Lysosomes are membrane‐enclosed organelles that play key roles in degrading and recycling cellular debris, cellular signaling, and energy metabolism processes. Confinement of amphiphilic peptides in the lysosome to construct functional nanostructures through noncovalent interactions is an emerging approach to tune the homeostasis of lysosome. After briefly introducing the importance of lysosome and
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Endogenous Antimicrobial‐Immunomodulatory Molecules: Networking Biomolecules of Innate Immunity ChemBioChem (IF 3.2) Pub Date : 2024-04-25 Donald F Weaver
Endogenous antimicrobial‐immunomodulatory molecules (EAIMs) are essential to immune‐mediated human health and evolution. Conventionally, antimicrobial peptides (AMPs) have been regarded as the dominant endogenous antimicrobial molecule; however, AMPs are not sufficient to account for the full spectrum of antimicrobial‐immunomodulatory duality occurring within the human body. The threat posed by pathogenic
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Enterolyin S, a Polythiazole‐containing Hemolytic Peptide from Enterococcus caccae ChemBioChem (IF 3.2) Pub Date : 2024-04-22 Chengyou Shi, Varshal A. Patel, Douglas A. Mitchell, Huimin Zhao
The β‐hemolytic factor streptolysin S (SLS) is an important linear azol(in)e‐containing peptide (LAP) that contributes significantly to the virulence of Streptococcus pyogenes. Despite its discovery 85 years ago, SLS has evaded structural characterizing owing to its notoriously problematic physicochemical properties. Here, we report the discovery and characterization of a structurally analogous hemolytic
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A Platinum-Aluminum Bimetallic Salen Complex for Pro-senescence Cancer Therapy ChemBioChem (IF 3.2) Pub Date : 2024-04-19 Juan Tang, Yahui Yang, Hao-Yan Yin, Bin Ma, Mengliang Zhu, Zi-Shu Yang, Xin-Xin Peng, Feifei Jia, Yao Zhao, Fuyi Wang, Tianfeng Chen, Jun-Long Zhang
Cell senescence is defined as irreversible cell cycle arrest, which can be triggered by telomere shortening or by various types of genotoxic stress. Induction of senescence is emerging as a new strategy for the treatment of cancer, especially when sequentially combined with a second senolytic drug capable of killing the resulting senescent cells, however severely suffering from the undesired off-target
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Proteomic Profiling of Antimalarial Plasmodione Using 3-Benz(o)ylmenadione Affinity-Based Probes ChemBioChem (IF 3.2) Pub Date : 2024-04-19 Ilaria Iacobucci, Vittoria Monaco, Agnès Hovasse, Baptiste Dupouy, Rodrigue Keumoe, Bogdan Cichocki, Mourad Elhabiri, Brigitte Meunier, Jean-Marc Strub, Maria Monti, Sarah Cianférani, Stéphanie A. Blandin, Christine Schaeffer-Reiss, Elisabeth Davioud-Charvet
Understanding the mechanisms of drug action in malarial parasites is crucial for the development of new drugs to combat infection and to counteract drug resistance. Proteomics is a widely used approach to study host-pathogen systems and to identify drug protein targets. Plasmodione is an antiplasmodial early-lead drug exerting potent activities against young asexual and sexual blood stages in vitro
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Click, Compute, Create: A Review of Web-based Tools for Enzyme Engineering ChemBioChem (IF 3.2) Pub Date : 2024-04-18 Adrian Tripp, Markus Braun, Florian Wieser, Gustav Oberdorfer, Horst Lechner
Enzyme engineering, though pivotal across various biotechnological domains, is often plagued by its time-consuming and labor-intensive nature. This review aims to offer an overview of supportive in silico methodologies for this demanding endeavor. Starting from methods to predict protein structures, to classification of their activity and even the discovery of new enzymes we continue with describing
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USING FÖRSTER RESONANCE ENERGY TRANSFER (FRET) TO UNDERSTAND THE UBIQUITINATION LANDSCAPE ChemBioChem (IF 3.2) Pub Date : 2024-04-17 Jashanjot Kaur Gill, Gary Shaw
Förster resonance energy transfer (FRET) is a fluorescence technique that allows quantitative measurement of protein interactions, kinetics and dynamics. This review covers the use of FRET to study the structures and mechanisms of ubiquitination and related proteins. We survey FRET assays that have been developed where donor and acceptor fluorophores are placed on E1, E2 or E3 enzymes and ubiquitin
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Co-Immobilization of ADH and GDH on Metal-organic-framework: An Effective Biocatalyst for Asymmetric Reduction of Ketones ChemBioChem (IF 3.2) Pub Date : 2024-04-17 Lu Ran, Guorong Su, Zhenyan Yang, Shuke Wu, Huailong Teng
Chiral alcohols are not only important building blocks of various bioactive natural compounds and pharmaceuticals, but can serve as synthetic precursors for other valuable organic chemicals, thus the synthesis of these products is of great importance. Bio-catalysis represents one effective way to obtain these molecules, however, the weak stability and high cost of enzymes often hinder its broad application
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Design, Synthesis and Catalytic Activity of Protein Containing Thiotyrosine as an Active Site Residue ChemBioChem (IF 3.2) Pub Date : 2024-04-17 Thomas Bachelart, Shailesh Kumar, Alexis Jouin, Mo'ath Yousef, Bruno Kieffer, Vladimir Torbeev
Native chemical ligation is a key reaction in the toolbox of chemical methods for the synthesis of native and modified proteins. The catalysis of ligation is commonly performed by using small aryl-thiol molecules added at high concentrations. In this work, we incorporated thiotyrosine, a non-canonical amino acid containing an aryl-thiol moiety, into a designed cyclic protein « sans queue ni tête »
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Monomeric far-red and near-infrared fluorescent biliproteins of ultrahigh brightness ChemBioChem (IF 3.2) Pub Date : 2024-04-16 Xiang-Xiang Jiang, Ya-Nan Hou, Li-Wen Lu, Kai-Hong Zhao
Far-red and near-infrared fluorescent proteins have regions of maximum transmission in most tissues and can be widely used as fluorescent biomarkers. We report that fluorescent phycobiliproteins originating from the phycobilisome core subunit ApcF2 can covalently bind biliverdin, named BDFPs. To further improve BDFPs, we conducted a series of studies. Firstly, we mutated K53Q and T144A of BDFPs to
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Gold Nanoparticle Delivery of Glut1 siRNA Facilitates Glucose Starvation Therapy in Lung Cancer ChemBioChem (IF 3.2) Pub Date : 2024-04-16 Jiaqi Li, Jingyuan Yu, Qi Fang, Yan Du, Xiaojun Zhang
Glucose transporter protein‐1 (Glut1), is highly expressed in many cancer types and plays a crucial role in cancer progression through enhanced glucose transport. Its overexpression is associated with aggressive tumor behavior and poor prognosis. Herein, the nucleic acids modified gold nanoparticles (AuNPs) was synthesized to deliver small interfering RNA (siRNA) against Glut1 by microRNA 21 (miR‐21)
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Identifying Potential SOS1 Inhibitors via Virtual Screening of Multiple Small Molecule Libraries against KRAS‐SOS1 Interface ChemBioChem (IF 3.2) Pub Date : 2024-04-16 Saima Ikram, Ehsan Sayyah, Serdar Durdagi
The RAS‐MAPK signaling pathway, crucial for cell proliferation and differentiation, involves key proteins KRAS and SOS1. Mutations in the KRAS and SOS1 genes are implicated in various cancer types, including pancreatic, lung, and juvenile myelomonocytic leukemia. There is considerable interest in identifying inhibitors targeting KRAS and SOS1 to explore potential therapeutic strategies for cancer treatment
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Systematic evaluation of benchmark G4 probes and G4 clinical drugs using three biophysical methods: A guideline to evaluate rapidly G4‐binding affinity. ChemBioChem (IF 3.2) Pub Date : 2024-04-15 Eugenie Laigre, Hugues Bonnet, Claire Beauvineau, Thomas Lavergne, Daniela Verga, Eric Defrancq, Jerome Dejeu, Marie-Paule Teulade-Fichou
G‐quadruplex DNA structures (G4) are proven to interfere with most genetic and epigenetic processes. Small molecules binding these structures (G4 ligands) are invaluable tools to probe G4‐biology and address G4‐druggability in various diseases (cancer, viral infections). However, the large number of reported G4 ligands (> 1000) could lead to confusion while selecting one for a given application. Herein
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WALL‐IMMOBILIZED BIOCATALYST VS. PACKED BED IN MINIATURIZED CONTINUOUS REACTORS: PERFORMANCES AND SCALE‐UP ChemBioChem (IF 3.2) Pub Date : 2024-04-15 Maite Michaud, Guillaume Nonglaton, Zoé Anxionnaz-Minvielle
Sustainable biocatalysis syntheses have gained considerable popularity over the years. However, further optimizations – notably to reduce costs – are required if the methods are to be successfully deployed in a range of areas. As part of this drive, various enzyme immobilization strategies have been studied, alongside process intensification from batch to continuous production. The flow bioreactor
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Systematic analysis of the effect of genomic knock‐out of non‐essential promiscuous HAD‐like phosphatases YcsE, YitU and YwtE on flavin and adenylate content in Bacillus subtilis ChemBioChem (IF 3.2) Pub Date : 2024-04-15 Alexandra Scharf, Farshad La-Rostami, Boris A. Illarionov, Vivien Nemes, Anna M. Feldmann, Lars S. Höft, Henri Lösel, Adelbert Bacher, Markus Fischer
Studying the metabolic role of non‐essential promiscuous enzymes is a challenging task, as genetic manipulations usually do not reveal at which point(s) of the metabolic network the enzymatic activity of such protein is beneficial for the organism. Each of the HAD‐like phosphatases YcsE, YitU and YwtE of Bacillus subtilis catalyzes the dephosphorylation of 5‐amino‐6‐ribitylamino‐uracil 5’‐phosphate
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Peptide‐Based Recognition Agents of Histamine: A Biopanning Approach with Enhanced Specificity ChemBioChem (IF 3.2) Pub Date : 2024-04-15 Hafize Öz, Fahriye Ceyda Dudak
Histamine is a biogenic amine that poses a potential threat to public health due to its toxicological effects. In this study, we identified histamine‐binding peptides by screening a random 12‐mer peptide library, employing a novel biopanning approach that excluded histidine‐binding sequences in the final round. This additional step enhanced the selectivity of the peptides and prevented interference
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Utilization of Free and Dipeptide‐Bound Formyline and Pyrraline by Saccharomyces Yeasts ChemBioChem (IF 3.2) Pub Date : 2024-04-13 Anna-Lena Kertsch, Jana Einicke, Julia Miedl, Michael Hellwig, Thomas Henle
The utilization of the glycated amino acids formyline and pyrraline and their peptide‐bound derivatives by 14 Saccharomyces yeasts, including 6 beer yeasts (bottom and top fermenting), one wine yeast, 6 strains isolated from natural habitats and one laboratory reference yeast strain (wild type) was investigated. All yeasts were able to metabolize glycated amino acids via the Ehrlich pathway to the
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SARS‐CoV‐2 Spike Protein‐Derived Cyclic Peptides as Modulators of Spike Interaction with GRP78 ChemBioChem (IF 3.2) Pub Date : 2024-04-13 Nicholas Johnson, Craig Pattinson, Kate Burgoyne, Karolin Hijazi, Wael E Houssen, Bruce Forbes Milne
The human glucose‐regulated protein GRP78 is a human chaperone that translocactes to the cell surface when cells are under stress. Theoretical studies suggested it could be involved in SARS‐CoV‐2 virus entry to cells. In this work, we used in vitro surface plasmon resonance‐based assays to show that human GRP78 indeed binds to SARS‐CoV‐2 spike protein. We have designed and synthesised cyclic peptides
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AM404 Analogs as Activators of the 20S Isoform of the Human Proteasome ChemBioChem (IF 3.2) Pub Date : 2024-04-13 Andres Salazar, Kate Kragness, Diogo Feleciano, Darci Jones Trader
The proteasome is a multisubunit protease system responsible for the majority of the protein turnover in eukaryotic organisms. Dysregulation of this enzymatic complex leads to protein accumulation, subsequent aggregation, and ultimately diseased states; for that reason, positive modulation of its activity has been recently investigated as a therapeutic strategy for neurodegenerative and age‐related
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Chemistry of Strigolactones, Key Players in Plant Communication ChemBioChem (IF 3.2) Pub Date : 2024-04-12 Suzanne Daignan-Fornier, Antoinette Keita, Francois-Didier Boyer
Today, the use of artificial pesticides is questionable and the adaptation to global warming is a necessity. The promotion of favorable natural interactions in the rhizosphere offers interesting perspectives for changing the type of agriculture. Strigolactones (SLs), the latest class of phytohormones to be discovered, are also chemical mediators in the rhizosphere. We present in this review the diversity
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The PR‐10 protein Pru p 1 is an endonuclease that preferentially cleaves single‐stranded RNA ChemBioChem (IF 3.2) Pub Date : 2024-04-11 Manuel Röck, Sarah Viola Heel, Fabian Sebastian Juen, Reiner Eidelpes, Christoph Kreutz, Kathrin Breuker, Martin Tollinger
Pathogenesis‐related class 10 (PR‐10) proteins play a crucial role in plant defense by acting as ribonucleases. The specific mechanism of action and substrate specificity of these proteins have remained largely unexplored so far. In this study, we elucidate the enzymatic activity of Pru p 1, a PR‐10 protein from peach. We demonstrate that this protein catalyzes the endonucleolytic backbone cleavage
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Crystallization assisted dynamic kinetic resolution for the synthesis of (R)‐β‐methylphenethylamine ChemBioChem (IF 3.2) Pub Date : 2024-04-11 Feodor Belov, Alina Gazizova, Hannah Bork, Harald Gröger, Jan von Langermann
This study explores a combination of the concept of enantioselective enzymatic synthesis of β‐chiral amines through transamination with in situ product crystallization (ISPC) to overcome product inhibition. Using 2‐phenylpropanal as a readily available and easily racemizing substrate of choice, (R)‐β‐methylphenethylamine ((R)‐2‐phenylpropan‐1‐amine) concentrations of up to 250 mM and enantiomeric excesses
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Why Does Monoamine Oxidase (MAO) Catalyze the Oxidation of Some Tetrahydropyridines? ChemBioChem (IF 3.2) Pub Date : 2024-04-11 Nathan J. Price, Akiko Nakamura, Neal Castagnoli, James M. Tanko
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Effects of PNA Sequence and Target Site Selection on Function of a 4.5S Non‐coding RNA ChemBioChem (IF 3.2) Pub Date : 2024-04-10 Snehlata Saini, Khushboo Goel, Sudipta Ghosh, Anirban Das, Ishu Saraogi
Peptide nucleic acid (PNA) based antisense strategy is a promising therapeutic approach to specifically inhibit target gene expression. However, unlike protein coding genes, identification of an ideal PNA binding site for non‐coding RNA is not straightforward. Here, we compare the inhibitory activities of PNA molecules that bind a non‐coding 4.5S RNA called SRP RNA, a key component of the bacterial
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A Rhodanese‐Like Enzyme that Catalyzes Desulfination of Ergothioneine Sulfinic Acid ChemBioChem (IF 3.2) Pub Date : 2024-04-10 Egor Y. Nalivaiko, Florian P. Seebeck
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Detoxification of V‐nerve agents assisted by a microperoxidase: new pathway revealed by the use of a relevant VX simulant ChemBioChem (IF 3.2) Pub Date : 2024-04-09 Valmir Baptista da Silva, Jean-Pierre Mahy, Xavier Brazzolotto, Pierre-Yves Renard, Rémy Ricoux, Julien Legros
The biocatalyzed oxidative detoxification of the V‐series simulant PhX, by mean of the microperoxidase AcMP11, affords the corresponding phosphonothioate as the prominent product instead of the classical P‐S and P‐O bond cleavage. While PhX is structurally very close to the live agent VX (the methyl group is replaced by a phenyl), assessment with other surrogates missing the nucleophilic amino function
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Characterizing the Conformational Dynamics of Human SUMO2: Insights into its Interaction with Metal Ions and SIMs ChemBioChem (IF 3.2) Pub Date : 2024-04-09 Anupreet Kaur, Harpreet Singh, Dinesh Kumar, Venus Singh Mithu, Gagandeep Kaur Gahlay
SUMO (Small Ubiquitin‐like Modifiers) proteins are involved in a crucial post‐translational modification commonly termed as SUMOylation. In this work, we have investigated the native‐state conformational flexibility of human SUMO2 and its interaction with Cu2+ and Zn2+ ions using 15N/1H based 2D NMR spectroscopy. After SUMO1, SUMO2 is the most studied SUMO isoform in humans which shares 45% and ~80%
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A QUANTITATIVE METHOD TO DISTINGUISH CYTOSOLIC FROM ENDOSOME‐TRAPPED CELL‐PENETRATING PEPTIDES ChemBioChem (IF 3.2) Pub Date : 2024-04-09 Françoise Illien, Zoltán Bánóczi, Sandrine Sagan
Cell‐penetrating peptides are known to penetrate cells through endocytosis and translocation. The two pathways are hardly distinguished in current cell assays. We developed a reliable, simple and robust method to distinguish and quantify independently the two routes. The assay requires (DABCYL) 4‐(dimethylaminoazo)benzene‐4‐carboxylic acid‐ and (CF) carboxyfluorescein‐labeled peptides. When the labeled
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Reading and Writing the Ubiquitin Code Using Genetic Code Expansion ChemBioChem (IF 3.2) Pub Date : 2024-04-08 Rishi S. Patel, Nipuni M. Pannala, Chittaranjan Das
Deciphering ubiquitin proteoform signaling and its role in disease has been a long‐standing challenge in the field. The effects of ubiquitin modifications, its relation to ubiquitin‐related machineries, and its signaling output has been particularly limited by its reconstitution and means of characterization. Advances in genetic code expansion have contributed towards addressing these challenges by
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Enhancing PET Degrading Enzymes: A Combinatory Approach ChemBioChem (IF 3.2) Pub Date : 2024-04-08 Yvonne Joho, Santana Royan, Alessandro Caputo, Sophia Newton, Thomas Peat, Janet Newman, Colin Jackson, Albert Ardevol
Plastic waste has become a substantial environmental issue. A potential strategy to mitigate this problem is to use enzymatic hydrolysis of plastics to depolymerize post‐consumer waste and allow it to be reused. Over the last few decades, the use of enzymatic PET‐degrading enzymes has shown promise as a great solution for creating a circular plastic waste economy. PsPETase from Piscinibacter sakaiensis
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In‐vitro Clinical Diagnostics using RNA‐Cleaving DNAzymes ChemBioChem (IF 3.2) Pub Date : 2024-04-04 Monsur Ali, Parameswaran Nair, Alfredo Capretta, John David Brennan
Over the last three decades, significant advancements have been made in the development of biosensors and bioassays that use RNA‐cleaving DNAzymes (RCDs) as molecular recognition elements. While early examples of RCDs were primarily responsive to metal ions, the past decade has seen numerous RCDs reported for more clinically relevant targets such as bacteria, cancer cells, small metabolites, and protein
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In Silico Study of the Early Stages of Aggregation of β Sheet‐forming Antimicrobial Peptide GL13K ChemBioChem (IF 3.2) Pub Date : 2024-04-04 Mohammadreza Niknam Hamidabad, Natalya A. Watson, Lindsay N. Wright, Rachael Alexandra Mansbach
Antimicrobial peptides (AMPs) are of growing interest as potential candidates that may offer more resilience against antimicrobial resistance than traditional antibiotic agents. In this article, we perform the first in silico study of the synthetic ß sheet‐forming AMP GL13K. Through atomistic simulations of single and multi‐peptide systems under different conditions, we are able to shine a light on
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Cobalamins function as allosteric activators of an Angelman syndrome‐associated UBE3A/E6AP variant ChemBioChem (IF 3.2) Pub Date : 2024-04-04 Franziska Müller, Jasmin Jansen, Fabian Offensperger, Daniela Eichbichler, Florian Stengel, Martin Scheffner
Genetic aberrations of the maternal UBE3A allele, which encodes the E3 ubiquitin ligase E6AP, are the cause of Angelman syndrome (AS), an imprinting disorder. In most cases, the maternal UBE3A allele is not expressed. Yet, approximately 10 percent of AS individuals harbor distinct point mutations in the maternal allele resulting in the expression of full‐length E6AP variants that frequently display
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Front Cover: Ether Bond Cleavage of a Phenylcoumaran β-5 Lignin Model Compound and Polymeric Lignin Catalysed by a LigE-type Etherase from Agrobacterium sp. (ChemBioChem 8/2024) ChemBioChem (IF 3.2) Pub Date : 2024-04-03 Goran M. M. Rashid, Guillaume N. Rivière, Betty Cottyn-Boitte, Amel Majira, Laurent Cézard, Victoria Sodré, Richard Lam, Julia A. Fairbairn, Stéphanie Baumberger, Timothy D. H. Bugg
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Molecular Basis for Chemoselectivity Control in Oxidations of Internal Aryl‐Alkenes Catalyzed by Laboratory Evolved P450s ChemBioChem (IF 3.2) Pub Date : 2024-04-03 Jordi Soler, Sebastian Gergel, Stephan C Hammer, Marc Garcia-Borràs
P450 enzymes naturally perform selective oxidations of unfunctionalized hydrocarbon substrates, among other reactions. The adaptation of P450 enzymes to particular oxidative reactions involving alkenes is of great interest for the design of new biocatalysts. However, the mechanism that these enzymes utilize to precisely modulate the chemoselectivity and distinguishing between competing alkene double
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Biological Demands and Toxicity of Isoprenoid Precursors in Bacillus Subtilis Through Cell-Permeant Analogs of Isopentenyl Pyrophosphate and Dimethylallyl Pyrophosphate ChemBioChem (IF 3.2) Pub Date : 2024-04-03 Dillon P. McBee, Zackary N. Hulsey, Makayla R. Hedges, Joshua A. Baccile
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Using Capillary Electrophoresis to Investigate Protein Conformational and Compositional Heterogeneity ChemBioChem (IF 3.2) Pub Date : 2024-04-03 Aidan B. Grosas, Mar-dean Du Plessis, Joel J. Thevarajah, Marianne Gaborieau, John Carver, Patrice Castignolles
Detailed insights into protein structure/function relationships require robust characterization methodologies. Free‐solution capillary electrophoresis (CE) is a unique separation technique which is sensitive to the conformation and/or composition of proteins, and therefore provides information on the heterogeneity of these properties. Three unrelated, conformationally/compositionally‐altered proteins
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Bile Salt Hydrolase Activity-Based Probes for Monitoring Gut Microbial Bile Acid Metabolism ChemBioChem (IF 3.2) Pub Date : 2024-04-02 Lin Han, Raymond Xu, Amanda N. Conwell, Sola Takahashi, Bibudha Parasar, Pamela V. Chang
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Halo-1,2,3-triazoles: Valuable Compounds to Access Biologically Relevant Molecules ChemBioChem (IF 3.2) Pub Date : 2024-03-30 Dylan Coelho, Yoann Colas, Mélanie Ethève-Quelquejeu, Emmanuelle Braud, Laura Iannazzo
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Peptide-conjugated Nanoparticle Platforms for Targeted Delivery, Imaging, and Biosensing Applications ChemBioChem (IF 3.2) Pub Date : 2024-03-29 Bogdan Dragoş Ilieş, Ibrahim Yildiz, Manzar Abbas
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Glutamic Acid Modified Gold Nanorod Sensor for the Detection of Calcium ions in Neuronal Cells ChemBioChem (IF 3.2) Pub Date : 2024-03-28 Muhammed Shafeeque Rahman Pathiriparambath, Merin Joseph, Mithun Manog, Vinoy Thomas, Hanas Tharayil, Lakshmi V. Nair
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Overcoming Solubility Challenges: Liposomal isoCoQ-Carbazole as a Promising Anti-Tumor Agent for Inoperable and Radiation-Insensitive cancers ChemBioChem (IF 3.2) Pub Date : 2024-03-27 Diana Lamaa, Catherine Cailleau, Juliette Vergnaud, Julie Mougin, Jérôme Bignon, Mouad Alami, Elias Fattal, Abdallah Hamze, Nicolas Tsapis
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Investigating the Potential of Phenolic Compounds and Carbohydrates as Acceptor Substrates for Levansucrasse‐Catalyzed Transfructosylation Reaction ChemBioChem (IF 3.2) Pub Date : 2024-03-27 Muriel Wong Min, Lan Liu, Salwa Karboune
This study characterizes the acceptor specificity of levansucrases (LSs) from Gluconobacter oxydans (LS1), Vibrio natriegens (LS2), Novosphingobium aromaticivorans (LS3), and Paraburkholderia graminis (LS4) using sucrose as fructosyl donor and selected phenolic compounds and carbohydrates as acceptors. Overall, V. natriegens LS2 proved to be the best biocatalyst for the transfructosylation of phenolic
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PSL Chemical Biology Symposia: Recent Progress in Ferroptosis ChemBioChem (IF 3.2) Pub Date : 2024-03-26 Arthur Pereira, Leeroy Baron, Romain Bucci, Marina Plays, Giulia Bonasegale, Armel Picard–Bernes, Manuel Bibrowski, Nolwenn Morris, Sacha Marynberg, Fabien Sindikubwabo, Tatiana Cañeque, Sebastian Müller, Ludovic Colombeau, Stéphanie Solier, Yannick Bono, Christine Gaillet, Ludger Johannes, Alain Puisieux, Raphaël Rodriguez
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Cysteine-independent CRISPR-Associated Protein Labeling for Presentation and Co-delivery of Molecules Toward Genetic and Epigenetic Regulations ChemBioChem (IF 3.2) Pub Date : 2024-03-26 Sadiya Tanga, Arpita Hota, Arkadeep Karmakar, Paramita Banerjee, Basudeb Maji
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Split Proteins and Reassembly Modules for Biological Applications ChemBioChem (IF 3.2) Pub Date : 2024-03-26 Jieun Bae, Jonghoon Kim, Jongdoo Choi, Hwiyeong Lee, Minseob Koh
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Structure–Based Site–Directed Mutagenesis of Hydroxynitrile Lyase from Cyanogenic Millipede, Oxidus gracilis for Hydrocyanation and Henry Reactions ChemBioChem (IF 3.2) Pub Date : 2024-03-25 Siriporn Chaikaew, Yukio Watanabe, Daijun Zheng, Fumihiro Motojima, Takuya Yamaguchi, Yasuhisa Asano
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Climbing into their Skin to Understand Contextual Protein–Protein Associations and Localizations: Functional Investigations in Transgenic Live Model Organisms ChemBioChem (IF 3.2) Pub Date : 2024-03-21 Marcus J. C. Long, Yimon Aye
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Stereoselective Synthesis of the Gal-α-(1→3)-Gal-β-(1→3)-GlcNAc Trisaccharide: a new Ligand for DCAR and Mincle C-Type Lectin Receptors ChemBioChem (IF 3.2) Pub Date : 2024-03-20 Jacopo Tricomi, Mike Aoun, Bingze Xu, Rikard Holmdahl, Barbara Richichi
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Engineering the Activity of a Newly Identified Arylalkylamine N-Acetyltransferase in the Acetylation of 5-Hydroxytryptamine ChemBioChem (IF 3.2) Pub Date : 2024-03-19 Qing Wang, Congcong Li, Bo Yuan, Aiqun Yu, Ge Qu, Zhoutong Sun
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Synthesis of Pharmaceutically Relevant Arylamines Enabled by a Nitroreductase from Bacillus tequilensis ChemBioChem (IF 3.2) Pub Date : 2024-03-19 Sara Russo, Alejandro Prats Luján, Marco W. Fraaije, Gerrit J. Poelarends
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Dual-Emissive Iridium(III) Complexes and Their Applications in Biological Sensing and Imaging ChemBioChem (IF 3.2) Pub Date : 2024-03-15 Zhipeng Ruan, Jun Yang, Yonghua Li, Kenneth Yin Zhang
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Natural Products That Contain Higher Homologated Amino Acids ChemBioChem (IF 3.2) Pub Date : 2024-03-15 Skyler L. Owens, Shopno R. Ahmed, Rebecca M. Lang Harman, Laura E. Stewart, Shogo Mori
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Molecular Driving Forces in the Self‐Association of Silaffin Peptide R5 from MD Simulations ChemBioChem (IF 3.2) Pub Date : 2024-03-15 Coco Moke Mao, Janani Sampath, Jim Pfaendtner
The 19‐residue silaffin‐R5 peptide has been widely studied for its ability to precipitate uniform SiO2 particles through mild temperature and pH pathways, in the absence of any organic solvents. There is consensus that post‐translational modification (PTM) of side chains has a large impact on the biomineralization process. Thus, it is imperative to understand the precise mechanisms that dictate the
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Research Progress on the Assembly of Large DNA Fragments ChemBioChem (IF 3.2) Pub Date : 2024-03-13 Wei Tan, Qing Miao, Xuemei Jia, Ying Liu, Shuai Li, Dayong Yang
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Efficient Transferase Engineering for SAM Analog Synthesis from Iodoalkanes ChemBioChem (IF 3.2) Pub Date : 2024-03-13 Kai H. Schülke, Jana S. Fröse, Alina Klein, Marc Garcia-Borràs, Stephan C. Hammer
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Porphyrin−BODIPY Dyad: Enhancing Photodynamic Inactivation via Antenna Effect ChemBioChem (IF 3.2) Pub Date : 2024-03-13 María E. Pérez, Javier E. Durantini, Sol R. Martínez, Andrés M. Durantini, María E. Milanesio, Edgardo N. Durantini
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Novel Triazole-Containing “Dipeptides”: Synthesis, Molecular Docking and Analgesic Activity Studies ChemBioChem (IF 3.2) Pub Date : 2024-03-13 Tariel V. Ghochikyan, Arusyak G. Zhamharyan, Shushanik G. Afrikyan, Vardges R. Frangyan, Armen S. Galstyan
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Monitoring Anthracycline Cancer Drug-Nucleosome Interaction by NMR Using a Specific Isotope Labeling Approach for Nucleosomal DNA ChemBioChem (IF 3.2) Pub Date : 2024-03-12 Clara L. van Emmerik, Vincenzo Lobbia, Jacques Neefjes, Frank H. T. Nelissen, Hugo van Ingen