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Structural basis for the minimal bifunctional alginate epimerase AlgE3 from Azotobacter chroococcum FEBS Lett. (IF 3.5) Pub Date : 2024-04-23 Takaaki Fujiwara, Eriko Mano, Eriko Nango
Among the epimerases specific to alginate, some of them in Azotobacter genera convert β‐d‐mannuronic acid to α‐l‐guluronic acid but also have lyase activity to degrade alginate. The remarkable characteristics of these epimerases make it a promising enzyme for tailoring alginates to meet specific demands. Here, we determined the structure of the bifunctional mannuronan C‐5 epimerase AlgE3 from Azotobacter
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Selection of bifunctional RNAs with specificity for arginine and lipid membranes FEBS Lett. (IF 3.5) Pub Date : 2024-04-23 Teresa Janas, Karolina Sapoń, Tadeusz Janas
The molecular mechanisms of selective RNA loading into exosomes and other extracellular vesicles are not yet completely understood. In order to show that a pool of RNA sequences binds both the amino acid arginine and lipid membranes, we constructed a bifunctional RNA 10Arg aptamer specific for arginine and lipid vesicles. The preference of RNA 10Arg for lipid rafts was visualized and confirmed using
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Deacylases—structure, function, and relationship to diseases FEBS Lett. (IF 3.5) Pub Date : 2024-04-22 Shuxian Wang, Xiaoke Xing, Jialin Ma, Sihao Zheng, Qibin Song, Pingfeng Zhang
Reversible S‐acylation plays a pivotal role in various biological processes, modulating protein functions such as subcellular localization, protein stability/activity, and protein–protein interactions. These modifications are mediated by acyltransferases and deacylases, among which the most abundant modification is S‐palmitoylation. Growing evidence has shown that this rivalrous pair of modifications
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Transcriptional activation of the Mycobacterium tuberculosis virulence‐associated small RNA MTS1338 by the response regulators DosR and PhoP FEBS Lett. (IF 3.5) Pub Date : 2024-04-19 Krishan Kumar, Tanmay Dutta
MTS1338, a distinctive small RNA in pathogenic mycobacteria, plays a crucial role in host–pathogen interactions during infection. Mycobacterial cells encounter heterogeneous stresses in macrophages, which highly upregulate MTS1338. A dormancy regulatory factor DosR regulates the intracellular abundance of MTS1338. Herein, we investigated the interplay of DosR and a low pH‐inducible gene regulator PhoP
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Increased ROS levels in mitochondrial outer membrane protein Mul1‐deficient oocytes result in abnormal preimplantation embryogenesis FEBS Lett. (IF 3.5) Pub Date : 2024-04-19 Ann Nakai, Yuki Fukushima, Ayaka Yamamoto, Yuki Amatsu, Xiaoyan Chen, Mitsuhiro Nishigori, Yukino Yoshioka, Mari Kaneko, Takumi Koshiba, Toshio Watanabe
Reactive oxygen species (ROS) are associated with oocyte maturation inhibition, and N‐acetyl‐l‐cysteine (NAC) partially reduces their harmful effects. Mitochondrial E3 ubiquitin ligase 1 (Mul1) localizes to the mitochondrial outer membrane. We found that female Mul1‐deficient mice are infertile, and their oocytes contain high ROS concentrations. After fertilization, Mul1‐deficient embryos showed a
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Endogenous IFN‐γ facilitates Pneumocystis infection and downregulates carbohydrate receptors in CD4+ T cell‐depleted mice FEBS Lett. (IF 3.5) Pub Date : 2024-04-18 Yi Wang, Hisashi Nagase, Yoh‐ichi Tagawa, Shinsuke Taki, Masaya Takamoto
IFN‐γ plays a critical role in host defense against intracellular pathogens. IFN‐γ is produced in the bronchoalveolar lavage fluid of mice infected with Pneumocystis, but the role of IFN‐γ in host defense against Pneumocystis remains controversial. It has been previously reported that although exogenous IFN‐γ has beneficial effects on eradication of Pneumocystis, endogenous IFN‐γ has a negative impact
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Molecular dynamics simulations of intracellular lipid droplets: a new tool in the toolbox FEBS Lett. (IF 3.5) Pub Date : 2024-04-17 Jennifer Sapia, Stefano Vanni
Lipid droplets (LDs) are ubiquitous intracellular organelles with a central role in multiple lipid metabolic pathways. However, identifying correlations between their structural properties and their biological activity has proved challenging, owing to their unique physicochemical properties as compared with other cellular membranes. In recent years, molecular dynamics (MD) simulations, a computational
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Why an integrated view of gene expression studies on hematopoiesis in mouse aging is better than the sum of their parts FEBS Lett. (IF 3.5) Pub Date : 2024-04-17 Leonid V. Bystrykh
Globally, the human population is aging, with an increased proportion of people in “old age” (over 60 years). This trend leads to a growing demand in aging research, stimulating studies in animal models such as mice, fish, and invertebrates. Recently, we published a research summary on the aging of hematopoietic stem cells (HSCs) in C57BL/6 mice based on 12 gene expression datasets. Here, I discuss
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iChIP‐SILAC analysis identifies epigenetic regulators of CpG methylation of the p16INK4A gene FEBS Lett. (IF 3.5) Pub Date : 2024-04-17 Toshitsugu Fujita, Hodaka Fujii
Allele‐specific epigenetic events regulate the expression of specific genes such as tumor suppressor genes. Methods to biochemically identify epigenetic regulators remain limited. Here, we used insertional chromatin immunoprecipitation (iChIP) to address this issue. iChIP combined with quantitative mass spectrometry identified DNA methyltransferase 1 (DNMT1) and epigenetic regulators as proteins that
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Ngk1 kinase‐mediated N‐acetylglucosamine metabolism promotes UDP‐GlcNAc biosynthesis in Saccharomyces cerevisiae FEBS Lett. (IF 3.5) Pub Date : 2024-04-16 Ayano Nishikawa, Shuichi Karita, Midori Umekawa
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κB‐Ras proteins are fast‐exchanging GTPases and function via nucleotide‐independent binding of Ral GTPase‐activating protein complexes FEBS Lett. (IF 3.5) Pub Date : 2024-04-12 René Rasche, Lisa Helene Apken, Esther Michalke, Daniel Kümmel, Andrea Oeckinghaus
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Rejuvenating aged stem cells: therapeutic strategies to extend health and lifespan FEBS Lett. (IF 3.5) Pub Date : 2024-04-12 Francesca Matteini, Sara Montserrat‐Vazquez, M. Carolina Florian
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PAT mRNA decapping factors are required for proper development in Arabidopsis FEBS Lett. (IF 3.5) Pub Date : 2024-04-12 Zhangli Zuo, Milena Edna Roux, Yasin F. Dagdas, Eleazar Rodriguez, Morten Petersen
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Characterization of the endogenous retrovirus‐derived placenta‐specific soluble protein EnvV‐Fca from domestic cats FEBS Lett. (IF 3.5) Pub Date : 2024-04-12 Didik Pramono, Kenji Sugimoto, Tohru Kimura, Ariko Miyake, Kazuo Nishigaki
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The components of the AhR‐molecular chaperone complex differ depending on whether the ligands are toxic or non‐toxic FEBS Lett. (IF 3.5) Pub Date : 2024-04-12 Yukihiko Narita, Arisa Tamura, Shiori Hatakeyama, Seiya Uemura, Atsuko Miura, Asami Haga, Noriko Tsuji, Nozomi Fujie, Yukina Izumi, Taku Sugawara, Michiro Otaka, Ken Okamoto, Peng Lu, Suguru Okuda, Michio Suzuki, Koji Nagata, Hiroaki Shimizu, Hideaki Itoh
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OTUD6A orchestrates complex modulation of TEAD4‐mediated transcriptional programs FEBS Lett. (IF 3.5) Pub Date : 2024-04-10 Hyo Jin Kim, Yunsik Choi, Yuri Lee, Mi Hwangbo, Jongchan Kim
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Hepatitis B virus‐specific human stem cell memory T cells differentiate into cytotoxic T cells and eradicate HBV‐infected hepatocytes in mice FEBS Lett. (IF 3.5) Pub Date : 2024-04-10 Hiromi Abe‐Chayama, Takakazu Kawase, Tatsuo Ichinohe, Yuji Ishida, Chise Tateno, Makoto Hijikata, Kazuaki Chayama
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The DMT1 isoform lacking the iron‐response element regulates normal and malignant hematopoiesis viaNOTCH pathway activation FEBS Lett. (IF 3.5) Pub Date : 2024-04-10 Judith Hounjet, Linde Van Aerschot, Kim De Keersmaecker, Marc Vooijs, Kim R. Kampen
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Structural determinants for membrane binding of the EGFR juxtamembrane domain FEBS Lett. (IF 3.5) Pub Date : 2024-04-08 Ziwei Wu, Ling Li, Lina Zhu, Runhan Wang, Yingkui Dong, Yaoyao Zhang, Yujuan Wang, Junfeng Wang, Lei Zhu
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Structural and functional insights of itaconyl‐CoA hydratase from Pseudomonas aeruginosa highlight a novel N‐terminal hotdog fold FEBS Lett. (IF 3.5) Pub Date : 2024-04-05 Atanu Pramanik, Saumen Datta
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Skraban‐Deardorff intellectual disability syndrome‐associated mutations in WDR26 impair CTLH E3 complex assembly FEBS Lett. (IF 3.5) Pub Date : 2024-04-05 Annette Gross, Judith Müller, Jakub Chrustowicz, Alexander Strasser, Karthik V. Gottemukkala, Dawafuti Sherpa, Brenda A. Schulman, Peter J. Murray, Arno F. Alpi
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Gulp1 regulates chondrocyte growth arrest and differentiation via the TGF-β/SMAD2/3 pathway FEBS Lett. (IF 3.5) Pub Date : 2024-03-29 Dough Kim, Jung-Eun Kim, Seon Bhin Lee, Na Yeon Lee, Seung-Yoon Park
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The scorpion toxin BeKm‐1 blocks hERG cardiac potassium channels using an indispensable arginine residue FEBS Lett. (IF 3.5) Pub Date : 2024-04-02 Iana I. Zavarzina, Alexey I. Kuzmenkov, Nikita A. Dobrokhotov, Ekaterina E. Maleeva, Yuliya V. Korolkova, Steve Peigneur, Jan Tytgat, Nikolay A. Krylov, Alexander A. Vassilevski, Anton O. Chugunov
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Cryo‐EM structure of the Slo1 potassium channel with the auxiliary γ1 subunit suggests a mechanism for depolarization‐independent activation FEBS Lett. (IF 3.5) Pub Date : 2024-03-30 Milena Redhardt, Stefan Raunser, Tobias Raisch
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Caspase‐3 targets pro‐interleukin‐1β (IL‐1β) to restrict inflammation FEBS Lett. (IF 3.5) Pub Date : 2024-03-30 Seon Sook Kim, Su Ryeon Seo
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Generation of novel anti‐apoE monoclonal antibodies that selectively recognize apoE isoforms FEBS Lett. (IF 3.5) Pub Date : 2024-03-26 Takashi Ohgita, Koto Sakai, Nodoka Fukui, Norihiro Namba, Miyu Nakano, Yuki Kiguchi, Izumi Morita, Hiroyuki Oyama, Kouya Yamaki, Kohjiro Nagao, Norihiro Kobayashi, Hiroyuki Saito
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Comparative structural and functional analysis of the glycine‐rich regions of Class A and B J‐domain protein cochaperones of Hsp70 FEBS Lett. (IF 3.5) Pub Date : 2024-03-26 Szymon J. Ciesielski, Brenda A. Schilke, Milena Stolarska, Marco Tonelli, Bartlomiej Tomiczek, Elizabeth A. Craig
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ICLAMP: a novel technique to explore adenosine deamination via inosine chemical labeling and affinity molecular purification FEBS Lett. (IF 3.5) Pub Date : 2024-03-25 Yuxi Yang, Koki Nakayama, Shunpei Okada, Kazuki Sato, Takeshi Wada, Yuriko Sakaguchi, Ayaka Murayama, Tsutomu Suzuki, Masayuki Sakurai
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Do oral and gut microbiota communicate through redox pathways? A novel asset of the nitrate‐nitrite‐NO pathway FEBS Lett. (IF 3.5) Pub Date : 2024-03-25 Beatriz Paiva, João Laranjinha, Bárbara S. Rocha
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Molecular handcraft of a well-folded protein chimera FEBS Lett. (IF 3.5) Pub Date : 2024-03-20 Saacnicteh Toledo-Patiño, Sara Kathrin Goetz, Sooruban Shanmugaratnam, Birte Höcker, José Arcadio Farías-Rico
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EU-LIFE charter of independent life science research institutes FEBS Lett. (IF 3.5) Pub Date : 2024-03-21 Giulio Superti-Furga, Marta Agostinho, Jo Bury, Simon Cook, Christine Durinx, Anita Ender, Henri van Luenen, Anders H. Lund, René H. Medema, Marta Miączyńska, Dorthe Nickel, Pier Giuseppe Pelicci, Alain Puisieux, Samuli Ripatti, Maike Sander, Dirk Schubeler, Luis Serrano, Thomas Sommer, Katrine Sonne-Hansen, Pavel Tomančák, Joan Vives, John Vontas, Mónica Bettencourt-Dias
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Molecular analysis of the extracellular microenvironment: from form to function FEBS Lett. (IF 3.5) Pub Date : 2024-03-21 Jade K. Macdonald, Anand S. Mehta, Richard R. Drake, Peggi M. Angel
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Global transcriptome analysis reveals Salmonella Typhimurium employs nitrate metabolism to combat bile stress FEBS Lett. (IF 3.5) Pub Date : 2024-03-20 Madhulika Singh, Deepti Chandra, Sirisha Jagdish, Dipankar Nandi
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Drosophila germ granules are assembled from protein components through different modes of competing interactions with the multi-domain Tudor protein FEBS Lett. (IF 3.5) Pub Date : 2024-03-18 Wahiduzzaman, Samuel J. Tindell, Emma Alexander, Ethan Hackney, Kabita Kharel, Ryan Schmidtke, Alexey L. Arkov
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Macromolecular crowding has opposite effects on two critical sub‐steps of transcription initiation FEBS Lett. (IF 3.5) Pub Date : 2024-03-14 Pratip Mukherjee, Abhishek Mazumder
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Redox imbalance and metabolic defects in the context of Alzheimer disease FEBS Lett. (IF 3.5) Pub Date : 2024-03-13 Fabio Di Domenico, Chiara Lanzillotta, Marzia Perluigi
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Phosphorylation of TG‐interacting factor 1 at carboxyl‐terminal sites in response to insulin regulates adipocyte differentiation FEBS Lett. (IF 3.5) Pub Date : 2024-03-13 Yu‐Hao Chang, Yu‐Hua Tseng, Ju‐Ming Wang, Yau‐Sheng Tsai, Xin‐Lei Liu, Huei‐Sheng Huang
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Cdc73 is a major regulator of apoptosis-inducing factor 1 expression in Saccharomyces cerevisiae via H3K36 methylation FEBS Lett. (IF 3.5) Pub Date : 2024-03-11 Nitu Saha, Santoshi Acharjee, Raghuvir Singh Tomar
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How enzyme‐centered approaches are advancing research on cyclic oligo‐nucleotides FEBS Lett. (IF 3.5) Pub Date : 2024-03-08 Simon J. Wenzl, Carina C. de Oliveira Mann
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TERRA and the alternative lengthening of telomeres: a dangerous affair FEBS Lett. (IF 3.5) Pub Date : 2024-03-06 Claus M. Azzalin
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Uncovering domain motif interactions using high-throughput protein–protein interaction detection methods FEBS Lett. (IF 3.5) Pub Date : 2024-03-05 Sobia Idrees, Keshav Raj Paudel, Tayyaba Sadaf, Philip M. Hansbro
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Recruitment of ubiquitin E2 enzymes is determined jointly by the U-box domains and substrates of E3 ligases FEBS Lett. (IF 3.5) Pub Date : 2024-03-05 Bo Jin, Bei Li, Junyao Qu, Yiheng Sun, Mengran Wang, Changjiang Yang, Yuchen Fan, Yanan Wang, Peng Xu, Haiying Sun, Bo Jiang, Bo Zhao
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A life‐time of hematopoietic cell function: ascent, stability, and decline FEBS Lett. (IF 3.5) Pub Date : 2024-03-05 Anna Popravko, Lorna Mackintosh, Elaine Dzierzak
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Assessment of machine-learning predictions for the Mediator complex subunit MED25 ACID domain interactions with transactivation domains FEBS Lett. (IF 3.5) Pub Date : 2024-03-04 Didier Monté, Zoé Lens, Frédérique Dewitte, Vincent Villeret, Alexis Verger
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The extremophilic Andean isolate Acinetobacter sp. Ver3 expresses two ferredoxin-NADP+ reductase isoforms with different catalytic properties FEBS Lett. (IF 3.5) Pub Date : 2024-03-04 Alejandro Palavecino, Mariana Gabriela Sartorio, Néstor Carrillo, Néstor Cortez, Ana Bortolotti
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Crystal structure and solution scattering of Geobacillus stearothermophilus S9 peptidase reveal structural adaptations for carboxypeptidase activity FEBS Lett. (IF 3.5) Pub Date : 2024-03-01 Khileshwari Chandravanshi, Rahul Singh, Gauri N. Bhange, Ashwani Kumar, Pooja Yadav, Amit Kumar, Ravindra D. Makde
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How CBX proteins regulate normal and leukemic blood cells FEBS Lett. (IF 3.5) Pub Date : 2024-03-01 Anne P. de Groot, Gerald de Haan
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Plasmodium falciparum J-dot localized J domain protein A8iJp modulates the chaperone activity of human HSPA8 FEBS Lett. (IF 3.5) Pub Date : 2024-02-28 Welka Sahu, Tapaswini Bai, Aleena Das, Subhadip Mukherjee, Aradhana Prusty, Nipa Rani Mallick, Selvakumar Elangovan, K. Sony Reddy
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Resveratrol and its metabolites elicit neuroprotection via high‐affinity binding to the laminin receptor at low nanomolar concentrations FEBS Lett. (IF 3.5) Pub Date : 2024-02-28 Rayudu Gopalakrishna, Jennifer Aguilar, Andrew Oh, Emily Lee, Lucas Hou, Tammy Lee, Eric Xu, James Nguyen, William J. Mack
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Interlinked bi‐stable switches govern the cell fate commitment of embryonic stem cells FEBS Lett. (IF 3.5) Pub Date : 2024-02-27 Amitava Giri, Sandip Kar
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Probing the legitimate initiation of RNA synthesis by Qβ replicase with oligonucleotide primers FEBS Lett. (IF 3.5) Pub Date : 2024-02-26 Kirill V. Lobodin, Helena V. Chetverina, Alexander B. Chetverin
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Cryo-EM structure of the inactive ribosome complex accumulated in chick embryo cells in cold-stress conditions FEBS Lett. (IF 3.5) Pub Date : 2024-02-23 Liliia Nurullina, Salvatore Terrosu, Alexander G. Myasnikov, Lasse Bohl Jenner, Marat Yusupov
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Protein sorting upon exit from the endoplasmic reticulum dominates Golgi biogenesis in budding yeast FEBS Lett. (IF 3.5) Pub Date : 2024-02-23 Saku Sasaki, Philipp Schlarmann, Kazuki Hanaoka, Hinako Nishii, Hisao Moriya, Manuel Muñiz, Kouichi Funato
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Strigolactone biosynthesis in rice can occur via a 9-cis-3-OH-10′-apo-β-carotenal intermediate FEBS Lett. (IF 3.5) Pub Date : 2024-02-19 Jian You Wang, Guan-Ting Erica Chen, Aparna Balakrishna, Muhammad Jamil, Lamis Berqdar, Salim Al-Babili