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Assessment of cardiovascular functioning following sport-related concussion: A physiological perspective Auton. Neurosci. (IF 2.7) Pub Date : 2024-02-24 Chase J. Ellingson, M. Abdullah Shafiq, Cody A. Ellingson, J. Patrick Neary, Payam Dehghani, Jyotpal Singh
There is still much uncertainty surrounding the approach to diagnosing and managing a sport-related concussion (SRC). Neurobiological recovery may extend beyond clinical recovery following SRC, highlighting the need for objective physiological parameters to guide diagnosis and management. With an increased understanding of the connection between the heart and the brain, the utility of assessing cardiovascular
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Immunohistochemical localization of P2Y12 purinoceptors in the rat carotid body Auton. Neurosci. (IF 2.7) Pub Date : 2024-02-24 Takuya Yokoyama, Tomoyuki Saino, Nobuaki Nakamuta, Yoshio Yamamoto
The present study investigated the localization of the adenosine 5′-diphosphate (ADP)-selective P2Y12 purinoceptors in the rat carotid body using multilabeling immunofluorescence. Punctate immunoreactive products for P2Y12 were distributed in chemoreceptive type I cells immunoreactive to vesicular nucleotide transporter (VNUT) or dopamine beta-hydroxylase, but not in S100B-immunoreactive glial-like
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Innate and adaptive immune system consequences of post-traumatic stress disorder Auton. Neurosci. (IF 2.7) Pub Date : 2024-02-23 Tatlock H. Lauten, Tamara Natour, Adam J. Case
In the field of psychiatry, biological markers are rarely, if ever, used in the diagnosis of mental health disorders. Clinicians rely primarily on patient histories and behavioral symptoms to identify specific psychopathologies, which makes diagnosis highly subjective. Moreover, therapies for mental health disorders are aimed specifically at attenuating behavioral manifestations, which overlooks the
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The use and effectiveness of exercise for managing postural orthostatic tachycardia syndrome in young adults with joint hypermobility and related conditions: A scoping review Auton. Neurosci. (IF 2.7) Pub Date : 2024-02-13 Karen C. Peebles, Charl Jacobs, Logan Makaroff, Verity Pacey
Postural Orthostatic Tachycardia Syndrome (POTS) is a form of dysautonomia. It may occur in isolation, but frequently co-exists in individuals with hypermobile variants of Ehlers-Danlos Syndrome (EDS) and related conditions (chronic fatigue syndrome [CFS] and fibromyalgia). Exercise is recommended for non-pharmacological POTS management but needs to be individualised. This scoping review explores the
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Exploring quality of life in postural orthostatic tachycardia syndrome: A conceptual analysis Auton. Neurosci. (IF 2.7) Pub Date : 2024-02-12 William S. Frye, Brooke Greenberg
Postural Orthostatic Tachycardia Syndrome (POTS) is a complex autonomic disorder characterized by an abnormal increase in heart rate upon orthostatic change. While primarily described in its effect on the autonomic and cardiovascular system, it can cause significant functional impairment, leading to a diminished quality of life (QoL). This review paper aims to delve into the multifaceted dimensions
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Functional and 123I-MIBG scintigraphy assessment of cardiac adrenergic dysfunction in diabetes Auton. Neurosci. (IF 2.7) Pub Date : 2024-02-07 Thorsten K. Rasmussen, Per Borghammer, Nanna B. Finnerup, Troels S. Jensen, John Hansen, Karoline Knudsen, Wolfgang Singer, Guillaume Lamotte, Astrid J. Terkelsen
To assess the agreement between clinical cardiovascular adrenergic function and cardiac adrenergic innervation in type 2 diabetes patients (T2D). Thirty-three patients with T2D were investigated bimodally through (1) a standardized clinical cardiovascular adrenergic assessment, evaluating adequacy of blood pressure responses to the Valsalva maneuver and (2) I-meta-iodobenzylguanidine (MIBG) scintigraphy
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Mechanistic involvement of noradrenergic neuronal neurotransmitter release in cutaneous vasoconstriction during autonomic dysreflexia in persons with spinal cord injury Auton. Neurosci. (IF 2.7) Pub Date : 2024-01-27 Michelle Trbovich, Yubo Wu, Terry Romo, Wouker Koek, Dean Kellogg
Introduction Autonomic dysreflexia (AD) is a potentially life-threatening consequence in high (above T6) spinal cord injury that involves multiple incompletely understood mechanisms. While peripheral arteriolar vasoconstriction, which controls systemic vascular resistance, is documented to be pronounced during AD, the pathophysiological neurovascular junction mechanisms of this vasoconstriction are
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Limb-specific muscle sympathetic nerve activity responses to the cold pressor test Auton. Neurosci. (IF 2.7) Pub Date : 2023-12-29 Yasmine Coovadia, Brittany K. Schwende, Chloe E. Taylor, Charlotte W. Usselman
Recent studies have demonstrated that muscle sympathetic nerve activity (MSNA) responses to isometric exercise differs between active and inactive limbs. Whether limb-dependent responses are characteristic of responses to the cold pressor test (CPT) remains to be established. Therefore, we tested the hypothesis that CPT-induced MSNA responses differ between affected and unaffected limbs such that MSNA
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Maladaptive cardiac and behavioral reactivity to repeated vicarious stress exposure in socially bonded male prairie vole siblings Auton. Neurosci. (IF 2.7) Pub Date : 2023-12-27 Angela J. Grippo, Oreoluwa I. Akinbo, Alex Amidei, Joshua Wardwell, Marigny C. Normann, Sarah Ciosek, Dmitry Kovalev
Behaviors, emotions, and cardiovascular functions are influenced by stress. But these detrimental effects are not exclusive to an individual that directly experiences stress. Stress is also experienced vicariously through observation of another individual undergoing stress. The current study used the strong social bonds in socially monogamous prairie voles to determine effects of repeated vicarious
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The efficacy of non-pharmacological and non-pacing therapies in preventing vasovagal syncope: Tilt training, physical counter pressure maneuvers, and yoga - A systematic review and meta-analysis Auton. Neurosci. (IF 2.7) Pub Date : 2023-12-26 Abdulmajeed Alharbi, Momin Shah, Monik Gupta, Kassidy Rejent, Mona Mahmoud, Anas Alsughayer, Ahmad Alryheal, Wasef Sayeh, Rabbia Siddiqi, Abed Jabr, Eun Seo Kwak, Sadik Khuder, Ragheb Assaly, Blair Grubb
Background Vasovagal syncope (VVS) is a prevalent condition characterized by a sudden drop in blood pressure and heart rate, leading to a brief loss of consciousness and postural control. Recurrent episodes of VVS significantly impact the quality of life and are a common reason for emergency department visits. Non-pharmacological interventions, such as tilt training, physical counter pressure maneuvers
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Unraveling the lost balance: Adrenergic dysfunction in cancer cachexia Auton. Neurosci. (IF 2.7) Pub Date : 2023-12-06 Parham Diba, Ariana L. Sattler, Tetiana Korzun, Beth A. Habecker, Daniel L. Marks
Cancer cachexia, characterized by muscle wasting and widespread inflammation, poses a significant challenge for patients with cancer, profoundly impacting both their quality of life and treatment management. However, existing treatment modalities remain very limited, accentuating the necessity for innovative therapeutic interventions. Many recent studies demonstrated that changes in autonomic balance
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A retrospective analysis of neurogenic orthostatic hypotension in long-term care facility residents with recurrent falls Auton. Neurosci. (IF 2.7) Pub Date : 2023-12-05 Mehdi Shadmand, Brian Elliott, Jacob Lautze, Ali Mehdirad
Introduction Approximately 50 % of residents in long-term care facilities fall yearly and orthostatic hypotension accounts for a significant portion of them. Neurogenic orthostatic hypotension - a subtype of orthostatic hypotension – is important to be recognized as its management is far more complex; undertreatment of these older adults can lead to recurrent falls, high healthcare cost burden, and
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Inflammation of some visceral sensory systems and autonomic dysfunction in cardiovascular disease Auton. Neurosci. (IF 2.7) Pub Date : 2023-12-07 R.M. Lataro, F. Brognara, R. Iturriaga, J.F.R. Paton
The sensitization and hypertonicity of visceral afferents are highly relevant to the development and progression of cardiovascular and respiratory disease states. In this review, we described the evidence that the inflammatory process regulates visceral afferent sensitivity and tonicity, affecting the control of the cardiovascular and respiratory system. Some inflammatory mediators like nitric oxide
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Sympathetic remodeling and altered angiotensin-converting enzyme 2 localization occur in patients with cardiac disease but are not exacerbated by severe COVID-19 Auton. Neurosci. (IF 2.7) Pub Date : 2023-12-01 Creighton L. Kellum, Logan G. Kirkland, Tasha K. Nelson, Seth M. Jewett, Eric Rytkin, Igor R. Efimov, Donald B. Hoover, Paul V. Benson, Brant M. Wagener
Purpose Remodeling of sympathetic nerves and ACE2 has been implicated in cardiac pathology, and ACE2 also serves as a receptor for SARS-CoV-2. However, there is limited histological knowledge about the transmural distribution of sympathetic nerves and the cellular localization and distribution of ACE2 in human left ventricles from normal or diseased hearts. Goals of this study were to establish the
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Neuroimmune interplay in kidney health and disease: Role of renal nerves Auton. Neurosci. (IF 2.7) Pub Date : 2023-11-30 Madeline M. Gauthier, Sebastien Hayoz, Christopher T. Banek
Renal nerves and their role in physiology and disease have been a topic of increasing interest in the past few decades. Renal inflammation contributes to many cardiorenal disease conditions, including hypertension, chronic kidney disease, and polycystic kidney disease. Much is known about the role of renal sympathetic nerves in physiology – they contribute to the regulation of sodium reabsorption,
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Pooled rates and demographics of POTS following SARS-CoV-2 infection versus COVID-19 vaccination: Systematic review and meta-analysis Auton. Neurosci. (IF 2.7) Pub Date : 2023-11-23 Shin Jie Yong, Alice Halim, Shiliang Liu, Michael Halim, Ahmad A. Alshehri, Mohammed A. Alshahrani, Mohammed M. Alshahrani, Amal H. Alfaraj, Lamees M. Alburaiky, Faryal Khamis, , Bashayer M. AlShehail, Mubarak Alfaresi, Reyouf Al Azmi, Hawra Albayat, Nawal A. Al Kaabi, Mashael Alhajri, Kawthar Amur Salim Al Amri, Jameela Alsalman, Sarah A. Algosaibi, Ali A. Rabaan
Purpose To address recent concerns of postural orthostatic tachycardia syndrome (POTS) occurring after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and coronavirus disease 2019 (COVID-19) vaccination. Methods We searched PubMed, Web of Science, and Scopus as of 1st June 2023. We performed a systematic review and meta-analysis of pooled POTS rate in SARS-CoV-2-infected and
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Dynamic changes in renal sodium handling during sympathetic stimulation in healthy human males Auton. Neurosci. (IF 2.7) Pub Date : 2023-11-16 J.C.G. Petersen, T.E.N. Jonassen, N.-H. Holstein-Rathlou, L.G. Petersen, C.M. Sorensen
The temporal response of changes in renal sodium reabsorption during increased renal sympathetic nerve activity has not been investigated. Central hypovolemia by application of lower-body negative-pressure (LBNP) elicits baroreceptor mediated sympathetic reflexes to maintain arterial blood pressure. We hypothesized, that during 90 min LBNP, the renal sodium retention would increase rapidly, remain
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Validation of symptom measures in patients under investigation for postural orthostatic tachycardia syndrome (POTS): The Orthostatic Grading Scale (OGS) and the Symptom Screen for Small-fiber Polyneuropathy (SSS) Auton. Neurosci. (IF 2.7) Pub Date : 2023-11-11 Iris Knoop, Annie S.K. Jones, Nicholas Gall, Joseph Chilcot, William Pascoe, Rona Moss-Morris
Objectives Postural Orthostatic Tachycardia Syndrome (POTS) presents with a range of poorly delineated symptoms across several domains. There is an urgent need for standardized symptom reporting in POTS, but a lack of validated symptom burden instruments. Our aim was to evaluate the psychometric properties of two symptom burden measures: the Orthostatic Grading Scale (OGS) and the Symptom Screen for
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Mechanosensitive channels in the mechanical component of the exercise pressor reflex Auton. Neurosci. (IF 2.7) Pub Date : 2023-10-29 Amane Hori, Ayumi Fukazawa, Kimiaki Katanosaka, Masaki Mizuno, Norio Hotta
The cardiovascular response is appropriately regulated during exercise to meet the metabolic demands of the active muscles. The exercise pressor reflex is a neural feedback mechanism through thin-fiber muscle afferents activated by mechanical and metabolic stimuli in the active skeletal muscles. The mechanical component of this reflex is referred to as skeletal muscle mechanoreflex. Its initial step
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Targeted stimulation of the vagus nerve reduces renal injury in female mice with systemic lupus erythematosus Auton. Neurosci. (IF 2.7) Pub Date : 2023-11-01 Caroline Gusson Shimoura, Cassandra Y. Stubbs, Sarika Chaudhari, Viet Q. Dinh, Keisa W. Mathis
Pharmacological stimulation of the vagus nerve has been shown to suppress inflammation and reduce blood pressure in a murine model of systemic lupus erythematosus (SLE) that is characterized by hypertension, inflammation, renal injury and dysautonomia. The present study aims to directly stimulate vagal nerves at the level of the dorsal motor nucleus of the vagus (DMV) using designer receptors exclusively
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Distribution and morphology of calcitonin gene-related peptide (CGRP) innervation in flat mounts of whole rat atria and ventricles Auton. Neurosci. (IF 2.7) Pub Date : 2023-10-21 Jin Chen, Kohlton T. Bendowski, Ariege Bizanti, Yuanyuan Zhang, Jichao Ma, Donald B. Hoover, David Gozal, Kalyanam Shivkumar, Zixi Jack Cheng
Calcitonin gene-related peptide (CGRP) is widely used as a marker for nociceptive afferent axons. However, the distribution of CGRP-IR axons has not been fully determined in the whole rat heart. Immunohistochemically labeled flat-mounts of the right and left atria and ventricles, and the interventricular septum (IVS) in rats for CGRP were assessed with a Zeiss imager to generate complete montages of
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Heart rate variability and cardiovascular risk factors in patients with rheumatoid arthritis: A longitudinal study Auton. Neurosci. (IF 2.7) Pub Date : 2023-09-09 Sofia Erelund, Anna Södergren, Urban Wiklund, Nina Sundström
Background It is established that the risk of cardiovascular disease (CVD) is increased in patients with Rheumatoid Arthritis (RA). Heart rate variability (HRV) is a method for evaluating the activity in the cardiac autonomic nervous system. Our aim was to assess the longitudinal development of HRV in patients with RA and compare with healthy controls. Furthermore, we wanted to investigate associations
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Spontaneous baroreflex sensitivity is attenuated in male UCD-type 2 diabetes mellitus rats: A link between metabolic and autonomic dysfunction Auton. Neurosci. (IF 2.7) Pub Date : 2023-08-23 Milena Samora, Yu Huo, Richard K. McCuller, Suchit Chidurala, Kimber L. Stanhope, Peter J. Havel, Audrey J. Stone, Michelle L. Harrison
Patients with type 2 diabetes mellitus (T2DM) have impaired arterial baroreflex function, which may be linked to the co-existence of obesity. However, the role of obesity and its related metabolic impairments on baroreflex dysfunction in T2DM is unknown. This study aimed to investigate the role of visceral fat and adiponectin, the most abundant cytokine produced by adipocytes, on baroreflex dysfunction
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Impacts of covid-19 on sleep quality and autonomic function in elderly diabetic women Auton. Neurosci. (IF 2.7) Pub Date : 2023-08-22 Leonardo Hesley Ferraz Durans, Ellian Robert Vale Santos, Thamyres da Cruz Miranda, Helen Nara da Silva e Silva, Nivaldo de Jesus Silva Soares Júnior, Sarah Raquel Dutra Macedo, Cristiano Teixeira Mostarda
Aim to analyze the quality of sleep and cardiac autonomic modulation of elderly diabetic women in the post-covid-19 syndrome. Methodology 41 elderly women, aged 60–75 years, with a diagnosis of Type 2 Diabetes Mellitus and who had covid-19 were included, divided into three groups: 14 in the Diabetes without covid-19 group (DG), 15 in the Diabetes with covid-19 group (CG), 12 in the Diabetes with covid-19
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Heart rate variability as a marker and predictor of inflammation, nosocomial infection, and sepsis – A systematic review Auton. Neurosci. (IF 2.7) Pub Date : 2023-08-12 Josephine Adam, Sven Rupprecht, Erika C.S. Künstler, Dirk Hoyer
Purpose The autonomic nervous system interacts with the immune system via the inflammatory response. Heart rate variability (HRV), a marker of autonomic activity, is associated with inflammation, and nosocomial infections/sepsis, and has clinical implications for the monitoring of at-risk patients. Due to the vagal tone's influence on anti-inflammatory immune response, this association may predominately
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Sympathetic and angiotensinergic activity in spontaneously hypertensive rats treated with 3-amino-1,2,4-triazole Auton. Neurosci. (IF 2.7) Pub Date : 2023-07-09 Roberto Braz Pontes, Débora S.A. Colombari, Patrícia M. De Paula, Eduardo Colombari, Carina A.F. Andrade, Laurival A. De Luca, José V. Menani
Previous studies from our laboratory have shown that the pressor response to intracerebroventricular (icv) administered ANG II in normotensive rats or spontaneously hypertensive rats (SHRs) is attenuated by increased central H2O2 concentration, produced either by direct H2O2 icv injection or by increased endogenous H2O2 centrally in response to local catalase inhibition with 3-amino-1,2,4-triazole
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Enhancement of muscarinic receptor–mediated excitation in spontaneously hypertensive rat adrenal medullary chromaffin cells Auton. Neurosci. (IF 2.7) Pub Date : 2023-07-10 Masumi Inoue, Keita Harada
One of the mechanisms for hypertension is an increase in blood catecholamines due to increased secretion from sympathetic nerve terminals and adrenal medullary chromaffin (AMC) cells. Spontaneously hypertensive rats (SHRs) are used as an animal model of hypertension. Catecholamine secretion in AMC cells occurs in response to humoral factors and neuronal inputs from the sympathetic nerve fibres. Acetylcholine
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Aortic stiffness contributes to greater pressor responses during static hand grip exercise in healthy young and middle-aged normotensive men Auton. Neurosci. (IF 2.7) Pub Date : 2023-07-05 Denis J. Wakeham, Rachel N. Lord, Jack S. Talbot, Freya M. Lodge, Bryony A. Curry, Tony G. Dawkins, Lydia L. Simpson, Christopher J.A. Pugh, Rob E. Shave, Jonathan P. Moore
Central arterial stiffness can influence exercise blood pressure (BP) by increasing the rise in arterial pressure per unit increase in aortic inflow. Whether central arterial stiffness influences the pressor response to isometric handgrip exercise (HG) and post-exercise muscle ischemia (PEMI), two common laboratory tests to study sympathetic control of BP, is unknown. We studied 46 healthy non-hypertensive
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Adrenal gland response to adrenocorticotropic hormone is intact in patients with postural orthostatic tachycardia syndrome Auton. Neurosci. (IF 2.7) Pub Date : 2023-06-24 Jill K.H. Laurin, Oyebimbola A. Oyewunmi, Emily M. Garland, Alfredo Gamboa, Victor C. Nwazue, Sachin Y. Paranjape, Bonnie K. Black, Luis E. Okamoto, Cyndya A. Shibao, Italo Biaggioni, David Robertson, André Diedrich, William D. Dupont, Robert S. Sheldon, Satish R. Raj
Background Many patients with postural orthostatic tachycardia syndrome (POTS) are hypovolemic with plasma volume deficits of 10–30 %. Some also have low levels of aldosterone and diminished aldosterone-renin ratios despite elevations in angiotensin II, pointing to potential adrenal dysfunction. To assess adrenal gland responsiveness in POTS, we measured circulating levels of aldosterone and cortisol
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The clinical utility of the Breathing Pattern Assessment Tool (BPAT) to identify dysfunctional breathing (DB) in individuals living with postural orthostatic tachycardia syndrome (POTS) Auton. Neurosci. (IF 2.7) Pub Date : 2023-06-17 Charles C. Reilly, Sarah V. Floyd, Shehnaz Raniwalla, Nicholas Gall, Gerrard F. Rafferty
Background Dysfunctional breathing (DB) resulting in inappropriate breathlessness is common in individuals living with postural orthostatic tachycardia syndrome (POTS). DB in POTS is complex, multifactorial, and not routinely assessed clinically outside of specialist centres. To date DB in POTS has been identified and diagnosed predominately via cardiopulmonary exercise testing (CPEX), hyperventilation
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Stress and the autonomic nervous system Auton. Neurosci. (IF 2.7) Pub Date : 2023-05-10 David S. Goldstein
Abstract not available
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Hypoxia augments TRPM3-mediated calcium influx in vagal sensory neurons Auton. Neurosci. (IF 2.7) Pub Date : 2023-04-29 Katherine R. Langen, Heather A. Dantzler, Procopio Gama de Barcellos-Filho, David D. Kline
Transient receptor potential melastatin 3 (TRPM3) channels contribute to nodose afferent and brainstem nucleus tractus solitarii (nTS) activity. Exposure to short, sustained hypoxia (SH) and chronic intermittent hypoxia (CIH) enhances nTS activity, although the mechanisms are unknown. We hypothesized TRPM3 may contribute to increased neuronal activity in nTS-projecting nodose ganglia viscerosensory
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The effects of sex and menstrual cycle phase on sympathetic action potential recruitment patterns during hypercapnic-hypoxic apnea Auton. Neurosci. (IF 2.7) Pub Date : 2023-04-24 Yasmine Coovadia, J. Kevin Shoemaker, Charlotte W. Usselman
Previously, we demonstrated that integrated muscle sympathetic nerve activity (MSNA) responses to acute chemoreflex stress were augmented during the early follicular (EF) phase of the menstrual cycle relative to both the midluteal (ML) phase and males. These differences were most pronounced in the amplitude component of MSNA, suggesting EF-driven increases in action potential (AP) recruitment in females
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Exaggerated blood pressure elevation in response to orthostatic challenge, a post-acute sequelae of SARS-CoV-2 infection (PASC) after hospitalization Auton. Neurosci. (IF 2.7) Pub Date : 2023-04-21 J. Antonio González-Hermosillo G, Esteban Jorge Galarza, Onasis Vicente Fermín, José Manuel Núñez González, Lucia Mariel Félix Álvarez Tostado, Marco Antonio Estrada Lozano, Claudia Ruíz Rabasa, María del Rocio Martínez Alvarado
Objective Post-acute sequelae of SARS-COV-2 (PASC) are emerging as a major health challenge. Orthostatic intolerance secondary to autonomic failure has been found in PASC patients. This study investigated the effect of COVID-19 after recovery on blood pressure (BP) during the orthostatic challenge. Research design and methods Thirty-one out of 45 patients hospitalized due to COVID-19-related pneumonia
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Editorial of the special issue on autonomic nervous system and cerebral blood flow autoregulation Auton. Neurosci. (IF 2.7) Pub Date : 2023-04-10 Alberto Porta, Ronney B. Panerai
Abstract not available
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Gamma secretase activity modulates BMP-7-induced dendritic growth in primary rat sympathetic neurons Auton. Neurosci. (IF 2.7) Pub Date : 2023-04-06 Krystal Karunungan, Rachel H. Garza, Ana Cristina Grodzki, Megan Holt, Pamela J. Lein, Vidya Chandrasekaran
Autonomic dysfunction has been observed in Alzheimer's disease (AD); however, the effects of genes involved in AD on the peripheral nervous system are not well understood. Previous studies have shown that presenilin-1 (PSEN1), the catalytic subunit of the gamma secretase (γ-secretase) complex, mutations in which are associated with familial AD function, regulates dendritic growth in hippocampal neurons
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The sensory and affective components of pain differentially shape pupillary dilatation during cold pressor tests Auton. Neurosci. (IF 2.7) Pub Date : 2023-03-15 Peter D. Drummond, Katie J.R. Clark
Nociceptive and affective stimuli increase reflex sympathetic outflow to the pupils. To investigate effects of stimulus intensity, unpleasantness and distress on these pupillary reflexes, and to assess their stability, healthy participants immersed their hand in ice-water three times (for 20, 40 and 60 s; or 60, 40 and 20 s; or three times for 60 s) (N = 21 in each condition). Each ice-water immersion
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Role of circadian rhythms and melatonin in bladder function in heath and diseases Auton. Neurosci. (IF 2.7) Pub Date : 2023-03-02 Stewart Ramsay, Vladimir Zagorodnyuk
The circadian system modulates all visceral organ physiological processes including urine storage and voiding. The “master clock” of the circadian system lies within suprachiasmatic nucleus of the hypothalamus while “peripheral clocks” are found in most peripheral tissue and organs, including the urinary bladder. Disruptions of circadian rhythms can cause organ malfunction and disorder or exacerbate
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The role of the autonomic nervous system in cerebral blood flow regulation in stroke: A review Auton. Neurosci. (IF 2.7) Pub Date : 2023-02-27 Alex Mankoo, Sankanika Roy, Aaron Davies, Ronney B. Panerai, Thompson G. Robinson, Patrice Brassard, Lucy C. Beishon, Jatinder S. Minhas
Stroke is a pathophysiological condition which results in alterations in cerebral blood flow (CBF). The mechanism by which the brain maintains adequate CBF in presence of fluctuating cerebral perfusion pressure (CPP) is known as cerebral autoregulation (CA). Disturbances in CA may be influenced by a number of physiological pathways including the autonomic nervous system (ANS). The cerebrovascular system
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Topographical distribution and morphology of SP-IR axons in the antrum, pylorus, and duodenum of mice Auton. Neurosci. (IF 2.7) Pub Date : 2023-01-27 Anas Mistareehi, Kohlton T. Bendowski, Ariege Bizanti, Jazune Madas, Yuanyuan Zhang, Andrew M. Kwiat, Duyen Nguyen, Nicole Kogut, Jichao Ma, Jin Chen, Zixi (Jack) Cheng
Substance-P (SP) is a commonly used marker of nociceptive afferent axons, and it plays an important role in a variety of physiological functions including the regulation of motility, gut secretion, and vascular flow. Previously, we found that SP-immunoreactive (SP-IR) axons densely innervated the pyloric antrum of the flat-mount of the mouse whole stomach muscular layer. However, the regional distribution
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Abdominal TRPV1 channel desensitization enhances stress-induced hyperthermia during social stress in rats Auton. Neurosci. (IF 2.7) Pub Date : 2023-01-27 T.O. Reis, S.I.S.R. Noronha, P.M.A. Lima, A.R.R. De Abreu, L.B.T. Mesquita, F.I. Ferreira, F.C. Silva, D.A. Chianca-Jr, R.C. De Menezes
Aims In rats, stress-induced hyperthermia caused by social interaction depends on brown adipose tissue (BAT) thermogenesis and peripheral vasoconstriction. However, the peripheral mechanisms responsible for regulating the level of hyperthermia during social stress are still unknown. The transient receptor potential vanilloid 1 (TRPV1) subfamily, expressed in sensory and visceral neurons, can serve
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Cardiac interoception in patients accessing secondary mental health services: A transdiagnostic study Auton. Neurosci. (IF 2.7) Pub Date : 2023-01-13 Hugo D. Critchley, Samantha P. Sherrill, Donna L. Ewing, Cassandra Gould van Praag, Haniah Habash-Bailey, Lisa Quadt, Jessica A. Eccles, Fran Meeten, Anna-Marie Jones, Sarah N. Garfinkel
Background Abnormalities in the regulation of physiological arousal and interoceptive processing are implicated in the expression and maintenance of specific psychiatric conditions and symptoms. We undertook a cross-sectional characterisation of patients accessing secondary mental health services, recording measures relating to cardiac physiology and interoception, to understand how physiological state
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Investigating the possible mechanisms of autonomic dysfunction post-COVID-19 Auton. Neurosci. (IF 2.7) Pub Date : 2022-12-24 Maya Jammoul, Judith Naddour, Amir Madi, Mohammad Amine Reslan, Firas Hatoum, Jana Zeineddine, Wassim Abou-Kheir, Nada Lawand
Patients with long COVID suffer from many neurological manifestations that persist for 3 months following infection by SARS-CoV-2. Autonomic dysfunction (AD) or dysautonomia is one complication of long COVID that causes patients to experience fatigue, dizziness, syncope, dyspnea, orthostatic intolerance, nausea, vomiting, and heart palpitations. The pathophysiology behind AD onset post-COVID is largely
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Cerebral blood flow response to cardiorespiratory oscillations in healthy humans Auton. Neurosci. (IF 2.7) Pub Date : 2022-12-23 Nathalie Linn Anikken Holme, Ilias Zilakos, Maja Elstad, Maria Skytioti
Dynamic cerebral autoregulation (CA) characterizes the cerebral blood flow (CBF) response to abrupt changes in arterial blood pressure (ABP). CA operates at frequencies below 0.15 Hz. ABP regulation and probably CA are modified by autonomic nervous activity. We investigated the CBF response and CA dynamics to mild increase in sympathetic activity. Twelve healthy volunteers underwent oscillatory lower
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Dysautonomia and related outcomes in Guillain-Barre syndrome Auton. Neurosci. (IF 2.7) Pub Date : 2022-12-21 Lisette Bazán-Rodríguez, Jesus Alberto Ruiz-Avalos, Adib Jorge de Saráchaga, Eunice Martinez-Jimenez, Juan Carlos López-Hernández, Steven Vargas-Cañas
Background Guillain–Barre syndrome (GBS) presents an annual incidence of 1.2–2.3 per 100,000. Sympathetic and parasympathetic nervous systems' peripheral control of visceral organs is affected by GBS aberrant immune response. Associated cardiovascular, gastrointestinal, sudomotor, pupillary, and other systems disturbances cause significant morbidity and mortality. This study aims to evaluate the dysautonomia
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Prognosis value of pupillometry in COVID-19 patients admitted in intensive care unit Auton. Neurosci. (IF 2.7) Pub Date : 2022-12-17 Matthieu Daniel, David Charier, Bruno Pereira, Mathilde Pachcinski, Tarek Sharshar, Serge Molliex
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Neural networks involved in nausea in adult humans: A systematic review Auton. Neurosci. (IF 2.7) Pub Date : 2022-12-20 C. Varangot-Reille, G.J. Sanger, P.L.R. Andrews, A. Herranz-Gomez, L. Suso-Martí, J. de la Nava, F. Cuenca-Martínez
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GABAergic leptin receptor-expressing neurons in the dorsomedial hypothalamus project to brown adipose tissue-related neurons in the paraventricular nucleus of mice Auton. Neurosci. (IF 2.7) Pub Date : 2022-12-14 Yanyan Jiang, Kavon Rezai-Zadeh, Lucie D. Desmoulins, Heike Muenzberg, Andrei V. Derbenev, Andrea Zsombok
Brown adipose tissue (BAT) contributes to energy homeostasis via nonshivering thermogenesis. The BAT is densely innervated by the sympathetic nervous system (SNS) and activity of pre-autonomic neurons modulates the sympathetic outflow. Leptin, an adipocyte hormone, alters energy homeostasis and thermogenesis of BAT via several neuronal circuits; however, the cellular effects of leptin on interscapular
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Phenotyping autonomic neuropathy using principal component analysis Auton. Neurosci. (IF 2.7) Pub Date : 2022-12-10 Steven Lawrence, Bridget R. Mueller, Patrick Kwon, Jessica Robinson-Papp
To identify autonomic neuropathy (AN) phenotypes, we used principal component analysis on data from participants (N = 209) who underwent standardized autonomic testing including quantitative sudomotor axon reflex testing, and heart rate and blood pressure at rest and during tilt, Valsalva, and standardized deep breathing. The analysis identified seven clusters: 1) normal, 2) hyperadrenergic features
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Oral contraceptive use and menstrual cycle influence acute cerebrovascular response to standing Auton. Neurosci. (IF 2.7) Pub Date : 2022-12-08 C. Barranca, T.J. Pereira, H. Edgell
Purpose To determine if the menstrual cycle and oral contraceptives (OC) influence responses to acute orthostatic stress and if these factors are clinically relevant to the diagnosis of initial orthostatic hypotension (iOH). Methods Young, healthy women were recruited, including OC users (n = 12) and non-users (NOC; n = 9). Women were tested during the low hormone (LH; placebo pills; days 2–5 natural
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How to approach baseline imbalance in cross-randomised studies? Auton. Neurosci. (IF 2.7) Pub Date : 2022-12-06 Ali Gholamrezaei, Hassan Jafari
Abstract not available
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By trying different approaches (and transparent reporting)! Response to: How to approach baseline imbalance in cross-randomised studies? Auton. Neurosci. (IF 2.7) Pub Date : 2022-12-06 Julian Koenig, Michael Kaess
Abstract not available
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Expression of group II metabotropic glutamate receptors in rat superior cervical ganglion Auton. Neurosci. (IF 2.7) Pub Date : 2022-11-22 Xixi Wei, Chenlu Zhao, Xinyun Jia, Baosheng Zhao, Yuzhen Liu
Background The superior cervical ganglion (SCG) plays critical roles in the regulation of blood pressure and cardiac output. Metabotropic glutamate receptors (mGluRs) in the SCG are not clearly elucidated yet. Most studies on the expression and functions of mGluRs in the SCG focused on the cultured SCG neurons, and yet little information has been reported in the SCG tissue. Chronic intermittent hypoxia
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Self-reported symptom burden in postural orthostatic tachycardia syndrome (POTS): A narrative review of observational and interventional studies Auton. Neurosci. (IF 2.7) Pub Date : 2022-11-18 Iris Knoop, Federica Picariello, Emma Jenkinson, Nicholas Gall, Claudia Chisari, Rona Moss-Morris
Background and objective Postural Orthostatic Tachycardia Syndrome (POTS) is a chronic health condition affecting mostly women of childbearing age, and significantly impacting their health and quality of life. It is currently poorly understood with no approved licensed treatments. The aim of this systematic review was to contextualize the symptom burden of POTS, and review factors associated with this
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Exploring mechanisms of blood pressure regulation in response to device-guided and non-device-guided slow breathing: A mini review Auton. Neurosci. (IF 2.7) Pub Date : 2022-11-14 Harika Pingali, Stacy D. Hunter
Background Hypertension is a widespread disease that, if persistent, increases the risks of coronary heart disease mortality and morbidity. Slow breathing is a recommended blood pressure-lowering strategy though the mechanisms mediating its effects are unknown. Objective This review aims to evaluate autonomic and vascular function as potential mediators driving BP adaptive responses with slow breathing
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Correlation between heart rate variability and cerebral autoregulation in septic patients Auton. Neurosci. (IF 2.7) Pub Date : 2022-11-18 Armin Alvaro Quispe-Cornejo, Ilaria Alice Crippa, Péter Bakos, Andrea Dominguez-Faure, Jacques Creteur, Fabio Silvio Taccone
Background Heart rate variability (HRV) may provide an estimation of the autonomous nervous system (ANS) integrity in critically ill patients. Disturbances of cerebral autoregulation (CAR) may share common pathways of ANS dysfunction. Aim To explore whether changes in HRV and CAR index correlate in critically ill septic patients. Methods Prospectively collected data on septic adult (> 18 years) patients