-
Correction to “Stimulation‐induced respiratory enhancement in corticothalamic regions” Epilepsia (IF 5.6) Pub Date : 2024-05-04
-
Health care disparities in morbidity and mortality in adults with acute and remote status epilepticus: A national study Epilepsia (IF 5.6) Pub Date : 2024-04-30 Gabriela B. Tantillo, Deepa Dongarwar, Chethan P. Venkatasubba Rao, Amari Johnson, Stephanie Camey, Oriana Reyes, Mariana Baroni, Jaideep Kapur, Hamisu M. Salihu, Nathalie Jetté
ObjectiveAlthough disparities have been described in epilepsy care, their contribution to status epilepticus (SE) and associated outcomes remains understudied.MethodsWe used the 2010–2019 National Inpatient Sample to identify SE hospitalizations using International Classification of Diseases, Ninth Revision, Clinical Modification (ICD‐9‐CM)/ICD‐10‐CM codes. SE prevalence was stratified by demographics
-
Neuronal synchrony and critical bistability: Mechanistic biomarkers for localizing the epileptogenic network Epilepsia (IF 5.6) Pub Date : 2024-04-30 Sheng H. Wang, Gabriele Arnulfo, Lino Nobili, Vladislav Myrov, Paul Ferrari, Philippe Ciuciu, Satu Palva, J. Matias Palva
ObjectivePostsurgical seizure freedom in drug‐resistant epilepsy (DRE) patients varies from 30% to 80%, implying that in many cases the current approaches fail to fully map the epileptogenic zone (EZ). We aimed to advance a novel approach to better characterize epileptogenicity and investigate whether the EZ encompasses a broader epileptogenic network (EpiNet) beyond the seizure zone (SZ) that exhibits
-
Clinical prediction models for treatment outcomes in newly diagnosed epilepsy: A systematic review Epilepsia (IF 5.6) Pub Date : 2024-04-30 Corey Ratcliffe, Vishnav Pradeep, Anthony Marson, Simon S. Keller, Laura J. Bonnett
Up to 35% of individuals diagnosed with epilepsy continue to have seizures despite treatment, commonly referred to as drug‐resistant epilepsy. Uncontrolled seizures can directly, or indirectly, negatively impact an individual's quality of life. To inform clinical management and life decisions, it is important to be able to predict the likelihood of seizure control. Those likely to achieve seizure control
-
Ictal fast activity chirps as markers of the epileptogenic zone Epilepsia (IF 5.6) Pub Date : 2024-04-30 Roberta Di Giacomo, Alessandra Burini, Daniela Chiarello, Veronica Pelliccia, Francesco Deleo, Rita Garbelli, Marco de Curtis, Laura Tassi, Vadym Gnatkovsky
The identification of the epileptogenic zone (EZ) boundaries is crucial for effective focal epilepsy surgery. We verify the value of a neurophysiological biomarker of focal ictogenesis, characterized by a low‐voltage fast‐activity ictal pattern (chirp) recorded with intracerebral electrodes during invasive presurgical monitoring (stereoelectroencephalography [SEEG]). The frequency content of SEEG signals
-
Emerging roles of long non‐coding RNAs in human epilepsy Epilepsia (IF 5.6) Pub Date : 2024-04-30 Fatemeh Yazarlou, Leonard Lipovich, Jeffrey A. Loeb
Genome‐scale biological studies conducted in the post‐genomic era have revealed that two‐thirds of human genes do not encode proteins. Most functional non‐coding RNA transcripts in humans are products of long non‐coding RNA (lncRNA) genes, an abundant but still poorly understood class of human genes. As a result of their fundamental and multitasking regulatory roles, lncRNAs are associated with a wide
-
Uncovering spatiotemporal dynamics of the corticothalamic network at ictal onset Epilepsia (IF 5.6) Pub Date : 2024-04-25 Saarang Panchavati, Atsuro Daida, Benjamin Edmonds, Makoto Miyakoshi, Shingo Oana, Samuel S. Ahn, Corey Arnold, Noriko Salamon, Raman Sankar, Aria Fallah, William Speier, Hiroki Nariai
ObjectiveAlthough the clinical efficacy of deep brain stimulation targeting the anterior nucleus (AN) and centromedian nucleus (CM) of the thalamus has been actively investigated for the treatment of medication‐resistant epilepsy, few studies have investigated dynamic ictal changes in corticothalamic connectivity in human electroencephalographic (EEG) recording. This study aims to establish the complex
-
The use of automated and AI‐driven algorithms for the detection of hippocampal sclerosis and focal cortical dysplasia Epilepsia (IF 5.6) Pub Date : 2024-04-20 Andrea Bernasconi, Ravnoor S. Gill, Neda Bernasconi
In drug‐resistant epilepsy, magnetic resonance imaging (MRI) plays a central role in detecting lesions as it offers unmatched spatial resolution and whole‐brain coverage. In addition, the last decade has witnessed continued developments in MRI‐based computer‐aided machine‐learning techniques for improved diagnosis and prognosis. In this review, we focus on automated algorithms for the detection of
-
Status epilepticus in Auckland, New Zealand: Treatment patterns and determinants of outcome in a prospective population‐based cohort Epilepsia (IF 5.6) Pub Date : 2024-04-18 Michael W. K. Fong, Eleanor Stephens, Alice Brockington, Jayaganth Jayabal, Shona Scott, Tony Zhang, Rhonda Litchfield, Erica Beilharz, Stuart R. Dalziel, Peter Jones, Kim Yates, Vanessa Thornton, Peter S. Bergin
ObjectiveDetermination of the real‐world performance of a health care system in the treatment of status epilepticus (SE).MethodsProspective, multicenter population‐based study of SE in Auckland, New Zealand (NZ) over 1 year, with data recorded in the EpiNet database. Focus on treatment patterns and determinants of SE duration and 30‐day mortality. The incidence, etiology, ethnic discrepancies, and
-
Stimulus‐induced arousal with transient electroencephalographic improvement distinguishes nonictal from ictal generalized periodic discharges Epilepsia (IF 5.6) Pub Date : 2024-04-16 Philippe Gélisse, William O. Tatum, Arielle Crespel, Peter W. Kaplan
In the case of suspicion of nonconvulsive status epilepticus (NCSE), reactivity on electroencephalograms (EEGs) can provide valuable diagnostic information. Reactivity refers to responses to auditory or somatosensory stimulation, with changes in amplitude and frequency of background activity. Because of self‐perpetuating processes and the failure of self‐terminating mechanisms, status epilepticus is
-
Thalamic stereoelectroencephalography for neuromodulation target selection: Proof of concept and review of literature of pulvinar direct electrical stimulation Epilepsia (IF 5.6) Pub Date : 2024-04-16 Naoki Ikegaya, Thandar Aung, Arka Mallela, Jasmine L. Hect, Arianna Damiani, Jorge A. Gonzalez‐Martinez
In patients with drug‐resistant epilepsy (DRE) who are not candidates for resective surgery, various thalamic nuclei, including the anterior, centromedian, and pulvinar nuclei, have been extensively investigated as targets for neuromodulation. However, the therapeutic effects of different targets for thalamic neuromodulation on various types of epilepsy are not well understood. Here, we present a 32‐year‐old
-
Comparative analysis of patients with new onset refractory status epilepticus preceded by fever (febrile infection‐related epilepsy syndrome) versus without prior fever: An interim analysis Epilepsia (IF 5.6) Pub Date : 2024-04-16 Anthony D. Jimenez, Margaret Gopaul, Hannah Asbell, Seyhmus Aydemir, Maysaa M. Basha, Ayush Batra, Charlotte Damien, Gregory S. Day, Onome Eka, Krista Eschbach, Safoora Fatima, Madeline C. Fields, Brandon Foreman, Elizabeth E. Gerard, Teneille E. Gofton, Hiba A. Haider, Stephen T. Hantus, Sara Hocker, Amy Jongeling, Mariel Kalkach Aparicio, Padmaja Kandula, Peter Kang, Karnig Kazazian, Marissa A. Kellogg
Febrile infection‐related epilepsy syndrome (FIRES) is a subset of new onset refractory status epilepticus (NORSE) that involves a febrile infection prior to the onset of the refractory status epilepticus. It is unclear whether FIRES and non‐FIRES NORSE are distinct conditions. Here, we compare 34 patients with FIRES to 30 patients with non‐FIRES NORSE for demographics, clinical features, neuroimaging
-
Rehabilitation in patients with newly diagnosed epilepsy: A controlled, 1‐year follow‐up study on a specialized inpatient rehabilitation program Epilepsia (IF 5.6) Pub Date : 2024-04-16 Ulrich Specht, Denise Lahr, Theodor W. May, Pascal Speicher, Heiko Hausfeld, Ingrid Coban, Birgitt Müffelmann, Christian G. Bien, Anne Hagemann
ObjectivesTo evaluate the efficacy of a specialized inpatient rehabilitation program in patients with newly diagnosed epilepsy (NDE), who had been referred within 1 year after diagnosis.MethodsWe performed an open, prospective, controlled study comparing a 1‐year follow‐up assessment of patients with NDE after completing a rehabilitation program at an epilepsy center (rehabilitation group) with a control
-
-
Epilepsia – April 2024 Announcements Epilepsia (IF 5.6) Pub Date : 2024-04-15
ILAE CONGRESSES ILAE School on Neuroimaging 2024 (AMIE & SuSIE 2024) 15 - 18 May 2024 Potsdam, Berlin & Online XIII Congreso Latinoamericano de Epilepsia 15 - 18 June 2024 Santo Domingo, República Dominicana 6th ILAE School on Advanced EEG and Epilepsy in Dianalund 20 - 27 July 2024 Dianalund, Denmark 15th European Epilepsy Congress 7 - 11 September 2024 Rome, Italy 14th International Summer School
-
Hippocampal sclerosis and temporal lobe epilepsy following febrile status epilepticus: The FEBSTAT study Epilepsia (IF 5.6) Pub Date : 2024-04-12 Darrell V. Lewis, James Voyvodic, Shlomo Shinnar, Stephen Chan, Jacqueline A. Bello, Solomon L. Moshé, Douglas R. Nordli, L. Matthew Frank, John M. Pellock, Dale C. Hesdorffer, Yuan Xu, Ruth C. Shinnar, Syndi Seinfeld, Leon G. Epstein, David Masur, William Gallentine, Erica Weiss, Xiaoyan Deng, Shumei Sun
This study was undertaken to determine whether hippocampal T2 hyperintensity predicts sequelae of febrile status epilepticus, including hippocampal atrophy, sclerosis, and mesial temporal lobe epilepsy.
-
Ethosuximide lowers lamotrigine serum concentrations: Evidence for a clinically relevant interaction Epilepsia (IF 5.6) Pub Date : 2024-04-12 Anne Hagemann, Arne Herting, Dennis Klimpel, Christian G. Bien, Tilman Polster
We investigated the effect of comedication with ethosuximide (ESM) on lamotrigine (LTG) blood levels. Based on observations from clinical practice, we hypothesized that ESM reduces the LTG serum concentration. We additionally evaluated this effect in the presence of concomitant valproic acid (VPA). We retrospectively analyzed samples of inpatients from our department who had been treated with a combination
-
Prospective validation of a seizure diary forecasting falls short Epilepsia (IF 5.6) Pub Date : 2024-04-12 Daniel M. Goldenholz, Celena Eccleston, Robert Moss, M. Brandon Westover
ObjectiveRecently, a deep learning artificial intelligence (AI) model forecasted seizure risk using retrospective seizure diaries with higher accuracy than random forecasts. The present study sought to prospectively evaluate the same algorithm.MethodsWe recruited a prospective cohort of 46 people with epilepsy; 25 completed sufficient data entry for analysis (median = 5 months). We used the same AI
-
Clinical practice guidelines on the management of status epilepticus in adults: A systematic review Epilepsia (IF 5.6) Pub Date : 2024-04-12 Luca Vignatelli, Valentina Tontini, Stefano Meletti, Maria Camerlingo, Stefania Mazzoni, Giada Giovannini, Elena Pasini, Roberto Michelucci, Francesca Bisulli, Paolo Tinuper, Lidia Di Vito
ObjectiveStatus epilepticus (SE) is the second most common neurological emergency in adults. Despite improvements in the management of acute neurological conditions over the last decade, mortality is still durably high. Because a gap has emerged between SE management based on clinical practice guidelines (CPGs) and actual clinical practice, we conducted a systematic review of CPGs, assessing their
-
Response: Do all individuals with Dravet syndrome have intellectual disability? Epilepsia (IF 5.6) Pub Date : 2024-04-10 Sameer M. Zuberi, Elaine Wirrell, Paolo Tinuper, Rima Nabbout
We are grateful for the opportunity to respond to the letter: Do all individuals with Dravet syndrome have intellectual disability? from Reilly and colleagues.1 The authors of the International League Against Epilepsy (ILAE) position paper on Epilepsy Syndromes in Neonates & Infants feel that intellectual disability (ID) is an important mandatory criterion differentiating Dravet syndrome from the many
-
Enhancing the action of serotonin by three different mechanisms prevents spontaneous seizure‐induced mortality in Dravet mice Epilepsia (IF 5.6) Pub Date : 2024-04-09 Jialing Guo, Daniel Min, Emory K. Farrell, Yupeng Zhou, Carl L. Faingold, Joseph F. Cotten, Hua‐Jun Feng
ObjectiveSudden unexpected death in epilepsy (SUDEP) is an underestimated complication of epilepsy. Previous studies have demonstrated that enhancement of serotonergic neurotransmission suppresses seizure‐induced sudden death in evoked seizure models. However, it is unclear whether elevated serotonin (5‐HT) function will prevent spontaneous seizure‐induced mortality (SSIM), which is characteristic
-
Identification of a mosaic MTOR variant in purified neuronal DNA in a patient with focal cortical dysplasia using a novel depth electrode harvesting technique Epilepsia (IF 5.6) Pub Date : 2024-04-08 Karl Martin Klein, Rumika Mascarenhas, Daria Merrikh, Maryam Khanbabaei, Tatiana Maroilley, Navprabhjot Kaur, Yiping Liu, Tyler Soule, Minette Manalo, Goichiro Tamura, Julia Jacobs, Walter Hader, Gerald Pfeffer, Maja Tarailo‐Graovac
ObjectiveRecent studies have identified brain somatic variants as a cause of focal epilepsy. These studies relied on resected tissue from epilepsy surgery, which is not available in most patients. The use of trace tissue adherent to depth electrodes used for stereo electroencephalography (EEG) has been proposed as an alternative but is hampered by the low cell quality and contamination by nonbrain
-
New stimulation procedures for language mapping in stereo‐EEG Epilepsia (IF 5.6) Pub Date : 2024-04-06 Belén Abarrategui, Veronica Pelliccia, Ginevra Giovannelli, Michele Nichelatti, Serena Valenzano, Ezequiel Mikulan, Andrea Pigorini, Martina Revay, Pina Scarpa, Laura Tassi
ObjectiveCortical intracerebral electrical stimulation is an important tool for language mapping in the presurgical work‐up of patients with drug‐resistant focal epilepsy. Language mapping with stereo–electroencephalography (EEG) is usually performed by high‐frequency stimulations (HFS: 50 Hz), whereas low‐frequency stimulations (LFS: 1 Hz) are usually considered useful for primary cortices mapping
-
Epilepsy surgery in adults older than 50 years: A systematic review and meta‐analysis Epilepsia (IF 5.6) Pub Date : 2024-04-06 Arielle Vary O’Neal, Ishak Tamani, Christian W. Mendo, Colin B. Josephson, Jorge G. Burneo, David A. Steven, Mark R. Keezer
ObjectiveDespite the general safety and efficacy of epilepsy surgery, there is evidence that epilepsy surgery remains underutilized. Although there are an increasing number of studies reporting epilepsy surgery in older adults, there is no consensus on whether epilepsy surgery is efficacious or safe for this population. Our objective was to systematically assess the efficacy as well as safety of resective
-
Electrographic screening for infantile epileptic spasms syndrome in a single sleep–wake cycle Epilepsia (IF 5.6) Pub Date : 2024-04-04 John A. Mason, Elizabeth Juarez‐Colunga, Kelly G. Knupp
ObjectiveInfantile epileptic spasms syndrome (IESS) is a common and urgent diagnosis with seizure and nonseizure mimics. Evaluation with prolonged video–electroencephalography (EEG) can be time‐consuming and costly. This study investigated the use of EEG review of a single sleep–wake cycle to exclude IESS.MethodsWe retrospectively reviewed video‐EEG studies to rule out IESS in children between the
-
Correction to “Efficacy of cannabidiol in convulsive and nonconvulsive seizure types associated with treatment‐resistant epilepsies in the Expanded Access Program” Epilepsia (IF 5.6) Pub Date : 2024-04-04
Flamini RJ, Comi AM, Bebin EM, Chez MG, Clark G, Devinsky O, et al. Efficacy of cannabidiol in convulsive and nonconvulsive seizure types associated with treatment-resistant epilepsies in the Expanded Access Program. Epilepsia. 2023;64:e156–e163. https://doi.org/10.1111/epi.17665. In the author affiliations under the article title and author list, author Dr. Laurie Seltzer's affiliation “University
-
Population pharmacokinetics and dosing optimization of perampanel in children with epilepsy: A real‐world study Epilepsia (IF 5.6) Pub Date : 2024-04-04 Sichan Li, Jiaqin Yi, YaLi Tuo, Gang Nie, Jun Wang, Yang Wang, Dan Sun, Zhisheng Liu
ObjectiveThe purposes of this study were to explore the pharmacokinetics of perampanel (PER) in children with epilepsy, identify factors that contribute to pharmacokinetic variations among subjects, evaluate the connection between PER exposure and clinical outcome, and establish an evidence‐based approach for tailoring individualized antiepileptic treatment in this specific population.MethodsIn this
-
Health care utilization of Hispanic/Latino veterans with epilepsy: A national population‐based study Epilepsia (IF 5.6) Pub Date : 2024-04-01 Gabriela B. Tantillo, Erin Sullivan‐Baca, Rizwana Rehman, María Raquel López, Zulfi Haneef
ObjectiveHispanic/Latino people with epilepsy are a growing population that has been understudied in clinical epilepsy research. U.S. veterans are at a higher risk of epilepsy due to greater exposures including traumatic brain injury. Hispanic/Latino Veterans with Epilepsy (HL‐VWEs) represent a growing population; however the treatment utilization patterns of this population have been vastly understudied
-
Prescribing patterns for higher dose folic acid in pregnant women with epilepsy treated with antiseizure medication Epilepsia (IF 5.6) Pub Date : 2024-03-30 Håkon Magne Vegrim, Julie Werenberg Dreier, Jannicke Igland, Nils Erik Gilhus, Silje Alvestad, Mika Gissler, Maarit K. Leinonen, Yuelian Sun, Helga Zoega, Jakob Christensen, Marte‐Helene Bjørk, Torbjörn Tomson
ObjectiveThis study was undertaken to characterize the use of higher doses of folic acid (≥1 mg daily) in relation to pregnancy in Denmark, Norway, and Sweden in women with epilepsy treated with antiseizure medication (ASM).MethodsIn this observational study, we used data from national medical birth, patient, and prescription registers in Denmark, Norway, and Sweden to retrospectively identify pregnancies
-
Amygdala enlargement in temporal lobe epilepsy: Histopathology and surgical outcomes Epilepsia (IF 5.6) Pub Date : 2024-03-28 Lubna Shakhatreh, Ben Sinclair, Catriona McLean, Elaine Lui, Andrew P. Morokoff, James A. King, Zhibin Chen, Piero Perucca, Terence J. O'Brien, Patrick Kwan
ObjectivesAmygdala enlargement is detected on magnetic resonance imaging (MRI) in some patients with drug‐resistant temporal lobe epilepsy (TLE), but its clinical significance remains uncertain We aimed to assess if the presence of amygdala enlargement (1) predicted seizure outcome following anterior temporal lobectomy with amygdalohippocampectomy (ATL‐AH) and (2) was associated with specific histopathological
-
Acetazolamide as an effective treatment for pilomotor seizures in autoimmune encephalitis Epilepsia (IF 5.6) Pub Date : 2024-03-27 Kia Gilani, Apameh Tarazi, Richard Wennberg
Pilomotor seizures are strongly associated with autoimmune encephalitis (AE), particularly anti‐LGI1 encephalitis. The carbonic anhydrase inhibitor acetazolamide may have special efficacy for treating AE‐associated pilomotor seizures. Six patients with AE (five anti‐LGI1, one seronegative) and temporal lobe pilomotor seizures (five with seizures inducible by hyperventilation) were treated with acetazolamide
-
Frailty as a comprehensive health measure beyond seizure control in patients with epilepsy: A cross‐sectional study Epilepsia (IF 5.6) Pub Date : 2024-03-27 Emanuele Cerulli Irelli, Maria S. Borioni, Alessandra Morano, Adolfo Mazzeo, Pierludovico Moro, Biagio Orlando, Enrico M. Salamone, Luca Giordano, Alessio Petrungaro, Marco Toccaceli Blasi, Anna T. Giallonardo, Marco Canevelli, Carlo Di Bonaventura
ObjectiveDue to the high clinical heterogeneity of epilepsy, there is a critical need for novel metrics aimed at capturing its biological and phenotypic complexity. Frailty is increasingly recognized in various medical disciplines as a useful construct to understand differences in susceptibility to adverse outcomes. Here, we develop a frailty index (FI) for patients with epilepsy (PwE) and explore
-
Correction to “Home recording of 3‐Hz spike–wave discharges in adults with absence epilepsy using the wearable Sensor Dot” Epilepsia (IF 5.6) Pub Date : 2024-03-23
Swinnen L, Chatzichristos C, Bhagubai M, Broux V, Zabler N, Dümpelmann M, et al. Home recording of 3-Hz spike–wave discharges in adults with absence epilepsy using the wearable Sensor Dot. Epilepsia. 2024; 65: 378–388. https://doi.org/10.1111/epi.17839 This erratum corrects six erroneous references in the above article by Swinnen et al. In paragraph 3 of the Introduction, in the text ‘Regarding detection
-
Circadian changes in aperiodic activity are correlated with seizure reduction in patients with mesial temporal lobe epilepsy treated with responsive neurostimulation Epilepsia (IF 5.6) Pub Date : 2024-03-22 Chantel M. Charlebois, Daria Nesterovich Anderson, Elliot H. Smith, Tyler S. Davis, Blake J. Newman, Angela Y. Peters, Amir M. Arain, Alan D. Dorval, John D. Rolston, Christopher R. Butson
ObjectivesResponsive neurostimulation (RNS) is an established therapy for drug‐resistant epilepsy that delivers direct electrical brain stimulation in response to detected epileptiform activity. However, despite an overall reduction in seizure frequency, clinical outcomes are variable, and few patients become seizure‐free. The aim of this retrospective study was to evaluate aperiodic electrophysiological
-
Edge‐wise analysis reveals white matter connectivity associated with focal to bilateral tonic–clonic seizures Epilepsia (IF 5.6) Pub Date : 2024-03-22 Sam S. Javidi, Xiaosong He, Ankeeta Ankeeta, Qirui Zhang, Salvatore Citro, Michael R. Sperling, Joseph I. Tracy
ObjectiveFocal to bilateral tonic–clonic seizures (FBTCS) represent a challenging subtype of focal temporal lobe epilepsy (TLE) in terms of both severity and treatment response. Most studies have focused on regional brain analysis that is agnostic to the distribution of white matter (WM) pathways associated with a node. We implemented a more selective, edge‐wise approach that allowed for identification
-
Racial disparities in the utilization of invasive neuromodulation devices for the treatment of drug-resistant focal epilepsy Epilepsia (IF 5.6) Pub Date : 2024-03-20 Juan Luis Alcala-Zermeno, Brandy Fureman, Caitlin L. Grzeskowiak, Ojas Potnis, Maria Taveras, Margaret W. Logan, Delanie Rybacki, Daniel Friedman, Daniel Lowenstein, Ruben Kuzniecky, Jacqueline French
Racial disparities affect multiple dimensions of epilepsy care including epilepsy surgery. This study aims to further explore these disparities by determining the utilization of invasive neuromodulation devices according to race and ethnicity in a multicenter study of patients living with focal drug-resistant epilepsy (DRE). We performed a post hoc analysis of the Human Epilepsy Project 2 (HEP2) data
-
Combining magnetic resonance fingerprinting with voxel‐based morphometric analysis to reduce false positives for focal cortical dysplasia detection Epilepsia (IF 5.6) Pub Date : 2024-03-21 Zheng Ding, Siyuan Hu, Ting‐Yu Su, Joon Yul Choi, Spencer Morris, Xiaofeng Wang, Ken Sakaie, Hiroatsu Murakami, Hans‐Jürgen Huppertz, Ingmar Blümcke, Stephen Jones, Imad Najm, Dan Ma, Zhong Irene Wang
ObjectiveWe aim to improve focal cortical dysplasia (FCD) detection by combining high‐resolution, three‐dimensional (3D) magnetic resonance fingerprinting (MRF) with voxel‐based morphometric magnetic resonance imaging (MRI) analysis.MethodsWe included 37 patients with pharmacoresistant focal epilepsy and FCD (10 IIa, 15 IIb, 10 mild Malformation of Cortical Development [mMCD], and 2 mMCD with oligodendroglial
-
Magnetic resonance imaging fingerprints of status epilepticus: A case–control study Epilepsia (IF 5.6) Pub Date : 2024-03-20 Pilar Bosque Varela, Payam Tabaee Damavandi, Lukas Machegger, Tanja Prüwasser, Georg Zimmermann, Andreas Oellerer, Jürgen Steinbacher, Mark McCoy, Johannes Pfaff, Eugen Trinka, Giorgi Kuchukhidze
ObjectiveStatus epilepticus (SE) is frequently associated with peri‐ictal magnetic resonance imaging (MRI) abnormalities (PMA). However, the anatomical distribution of these alterations has not been systematically studied. The aim of this study was to assess the localization patterns of PMA in patients with SE.MethodsIn this prospective case–control study, we compared the distribution and combinations
-
Motor seizures confer overall survival benefit in who grade 2 glioma Epilepsia (IF 5.6) Pub Date : 2024-03-20 Sam Fairclough, Paul Chumas, John Goodden, Melissa Maguire, Ryan K. Mathew
ObjectiveThe prevalence of epilepsy in World Health Organization (WHO) grade 2 glioma is high, with seizures being the presenting symptom in 60%–90%. We explore the epidemiology of seizures in this patient population in a regional neurosurgical center.MethodsElectronic health records of patients with histologically‐proven WHO grade 2 glioma (n = 228) were reviewed between 1997 and 2021, with data collected
-
Assessing short‐term and long‐term security and efficacy of anterior nucleus of the thalamus deep brain stimulation for treating drug‐resistant epilepsy: A systematic review and single‐arm meta‐analysis Epilepsia (IF 5.6) Pub Date : 2024-03-20 Gabriel Verly, Leonardo de Barros Oliveira, Thiffany Delfino, Sávio Batista, Thiago Lopes, Vitória Carvalho, Billy McBenedict, Matheus Oliveira, Raphael Bertani, Pedro Henrique Martins da Cunha, Wellingson Paiva, Bruno Lima Pessoa
Deep brain stimulation (DBS) of the anterior nucleus of the thalamus (ANT) is a widespread invasive procedure for treating drug‐resistant epilepsy. Nonetheless, there is a persistent debate regarding the short‐term and long‐term efficacy and safety of ANT‐DBS. Thus we conducted a systematic review and meta‐analysis. Following Preferred Reporting Items for Systematic Reviews and Meta‐Analyses (PRISMA)
-
Status epilepticus: Is there a Stage 1 plus? Epilepsia (IF 5.6) Pub Date : 2024-03-20 Giuseppe Magro, Vincenzo Laterza
In status epilepticus (SE), “time is brain.” Currently, first‐line therapy consists of benzodiazepines (BDZs) and SE is classified by the response to treatment; stage 2 or established SE is defined as “BDZ‐resistant SE.” Nonetheless, this classification does not always work, especially in the case of prolonged convulsive SE, where many molecular changes occur and γ‐aminobutyric acid signaling becomes
-
Over‐ and underreporting of seizures: How big is the problem? Epilepsia (IF 5.6) Pub Date : 2024-03-19 Timothy Hannon, Kiran M. Fernandes, Victoria Wong, Ewan S. Nurse, Mark J. Cook
ObjectiveClinical decisions on managing epilepsy patients rely on patient accuracy regarding seizure reporting. Studies have noted disparities between patient‐reported seizures and electroencephalographic (EEG) findings during video‐EEG monitoring periods, chiefly highlighting underreporting of seizures, a well‐recognized phenomenon. However, seizure overreporting is a significant problem discussed
-
Correction to “Long‐term efficacy and safety of cannabidiol in patients with treatment‐resistant epilepsies: Four‐year results from the expanded access program” Epilepsia (IF 5.6) Pub Date : 2024-03-19
Szaflarski JP, Devinsky O, Lopez M, Park YD, Zentil PP, Patel AD, et al. Long-term efficacy and safety of cannabidiol in patients with treatment-resistant epilepsies: Four-year results from the expanded access program. Epilepsia. 2023;64:619–629. https://doi.org/10.1111/epi.17496 In the Results section, 3.1 Patients, it reads “The median age of patients was 13.5 years (range = 0–74.5) in the safety
-
-
Clinical outcomes among initial survivors of cryptogenic new‐onset refractory status epilepsy (NORSE) Epilepsia (IF 5.6) Pub Date : 2024-03-18 Daniel J. Costello, Elizabeth Matthews, Sidra Aurangzeb, Elisabeth Doran, Jessica Stack, Robb Wesselingh, Patricia Dugan, Hyunmi Choi, Chantal Depondt, Orrin Devinsky, Colin Doherty, Patrick Kwan, Mastura Monif, Terence J. O'Brien, Arjune Sen, Nicolas Gaspard
ObjectiveNew‐onset refractory status epilepticus (NORSE) is a rare but severe clinical syndrome. Despite rigorous evaluation, the underlying cause is unknown in 30%–50% of patients and treatment strategies are largely empirical. The aim of this study was to describe clinical outcomes in a cohort of well‐phenotyped, thoroughly investigated patients who survived the initial phase of cryptogenic NORSE
-
Epilepsia – March 2024 Announcements Epilepsia (IF 5.6) Pub Date : 2024-03-18
ILAE CONGRESSES 4th ILAE School on Neuropsychology in Epilepsy 3–8 March 2024 Lyon, France 6th ILAE School on EEG in the First Year of Life: From newborn to toddler 25–28 March 2024 Cambridge, UK & Online ILAE School on Neuroimaging 2024 (AMIE & SuSIE 2024) 15–18 May 2024 Potsdam, Berlin & Online XIII Congreso Latinoamericano de Epilepsia 15–18 June 2024 Santo Domingo, República Dominicana 6th ILAE
-
Clinical and molecular characterization of patients with YWHAG-related epilepsy Epilepsia (IF 5.6) Pub Date : 2024-03-16 Valentina Cetica, Tiziana Pisano, Gaetan Lesca, Dana Marafi, Laura Licchetta, Florence Riccardi, Davide Mei, Hon-yin B. Chung, Allan Bayat, Meena Balasubramanian, Daniel H. Lowenstein, Milda Endzinienė, Maha Alotaibi, Nathalie Villeneuve, Julia Jacobs, Bertrand Isidor, Roberta Solazzi, Nicolette S. den Hollander, Dragan Marjanovic, Christelle Rougeot-Jung, Julien Jung, Marion Lesieur-Sebellin, Andrea
YWHAG variant alleles have been associated with a rare disease trait whose clinical synopsis includes an early onset epileptic encephalopathy with predominantly myoclonic seizures, developmental delay/intellectual disability, and facial dysmorphisms. Through description of a large cohort, which doubles the number of reported patients, we further delineate the spectrum of YWHAG-related epilepsy.
-
Modification of brain conductivity in human focal epilepsy: A model‐based estimation from stereoelectroencephalography Epilepsia (IF 5.6) Pub Date : 2024-03-16 Stanislas Lagarde, Julien Modolo, Maxime Yochum, Andres Carvallo, Alice Ballabeni, Didier Scavarda, Romain Carron, Nathalie Villeneuve, Fabrice Bartolomei, Fabrice Wendling
ObjectiveWe have developed a novel method for estimating brain tissue electrical conductivity using low‐intensity pulse stereoelectroencephalography (SEEG) stimulation coupled with biophysical modeling. We evaluated the hypothesis that brain conductivity is correlated with the degree of epileptogenicity in patients with drug‐resistant focal epilepsy.MethodsWe used bipolar low‐intensity biphasic pulse
-
Somatic variants as a cause of drug‐resistant epilepsy including mesial temporal lobe epilepsy with hippocampal sclerosis Epilepsia (IF 5.6) Pub Date : 2024-03-16 Robert J. Carton, Michael G. Doyle, Hugh Kearney, Charles A. Steward, Nicholas J. Lench, Anthony Rogers, Erin L. Heinzen, Seamus McDonald, Joanna Fay, Austin Lacey, Alan Beausang, Jane Cryan, Francesca Brett, Hany El‐Naggar, Peter Widdess‐Walsh, Daniel Costello, Ronan Kilbride, Colin P. Doherty, Kieron J. Sweeney, Donncha F. O'Brien, David C. Henshall, Norman Delanty, Gianpiero L. Cavalleri, Katherine
ObjectiveThe contribution of somatic variants to epilepsy has recently been demonstrated, particularly in the etiology of malformations of cortical development. The aim of this study was to determine the diagnostic yield of somatic variants in genes that have been previously associated with a somatic or germline epilepsy model, ascertained from resected brain tissue from patients with multidrug‐resistant
-
Diet composition and sterilization modifies intestinal microbiome diversity and burden of Theiler's virus infection–induced acute seizures Epilepsia (IF 5.6) Pub Date : 2024-03-16 Dannielle K. Zierath, Stephanie Davidson, Jonathan Manoukian, Kevin M. Knox, H. Steve White, Stacey Meeker, Aaron Ericsson, Melissa Barker‐Haliski
ObjectiveBrain infection with Theiler's murine encephalomyelitis virus (TMEV) in C57BL/6J mice can induce acquired epileptogenesis. Diet alters acute seizure incidence in TMEV‐infected mice; yet it is unclear whether intestinal dysbiosis may also impact acute or chronic behavioral comorbidities. This study thus assessed the impact of diet formulation and sterilization on acute seizure presentation
-
Why did my seizures start now? Influences of lesion connectivity and genetic etiology on age at seizure onset in focal epilepsy Epilepsia (IF 5.6) Pub Date : 2024-03-16 Emma Macdonald‐Laurs, Aaron E. L. Warren, Richard J. Leventer, A. Simon Harvey
ObjectivePatients with focal, lesional epilepsy present with seizures at variable ages. Larger lesion size and overlap with sensorimotor or default mode network (DMN) have been associated with younger age at seizure onset in cohorts with mixed types of focal cortical dysplasia (FCD). Here, we studied determinants of age at seizure onset in patients with bottom‐of‐sulcus dysplasia (BOSD), a discrete
-
MyD88‐mediated signaling is critical for the generation of seizure responses and cognitive impairment in a model of anti‐N‐methyl‐D‐aspartate receptor encephalitis Epilepsia (IF 5.6) Pub Date : 2024-03-12 Olga Taraschenko, Howard S. Fox, Ember Eldridge, Priscilla Heliso, Fetweh Al‐Saleem, Scott Dessain, George Casale, Gregory Willcockson, Kayley Anderson, Wenyi Wang, Raymond Dingledine
ObjectiveWe previously demonstrated that interleukin‐1 receptor‐mediated immune activation contributes to seizure severity and memory loss in anti‐N‐methyl‐D‐aspartate receptor (NMDAR) encephalitis. In the present study, we assessed the role of the myeloid differentiation primary response gene 88 (MyD88), an adaptor protein in Toll‐like receptor signaling, in the key phenotypic characteristics of anti‐NMDAR
-
Association of midazolam route of administration and need for recurrent dosing among children with seizures cared for by emergency medical services Epilepsia (IF 5.6) Pub Date : 2024-03-12 Sriram Ramgopal, Sylvia Owusu‐Ansah, Remle P. Crowe, Masashi Okubo, Christian Martin‐Gill
ObjectiveNational guidelines in the United States recommend the intramuscular and intranasal routes for midazolam for the management of seizures in the prehospital setting. We evaluated the association of route of midazolam administration with the use of additional benzodiazepine doses for children with seizures cared for by emergency medical services (EMS).MethodsWe conducted a retrospective cohort
-
Specific consistency score for rational selection of epilepsy resection surgery candidates Epilepsia (IF 5.6) Pub Date : 2024-03-12 Maya Tojima, Akihiro Shimotake, Shuichiro Neshige, Tadashi Okada, Katsuya Kobayashi, Kiyohide Usami, Masao Matsuhashi, Masayuki Honda, Hirofumi Takeyama, Takefumi Hitomi, Takeshi Yoshida, Atsushi Yokoyama, Yasutaka Fushimi, Tsukasa Ueno, Yukihiro Yamao, Takayuki Kikuchi, Takao Namiki, Yoshiki Arakawa, Ryosuke Takahashi, Akio Ikeda
ObjectiveDegree of indication for epilepsy surgery is determined by taking multiple factors into account. This study aimed to investigate the usefulness of the Specific Consistency Score (SCS), a proposed score for focal epilepsy to rate the indication for epilepsy focal resection.MethodsThis retrospective cohort study included patients considered for resective epilepsy surgery in Kyoto University
-
Comprehensive phenotypes of patients with SYNGAP1‐related disorder reveals high rates of epilepsy and autism Epilepsia (IF 5.6) Pub Date : 2024-03-12 Kimberly Wiltrout, Elise Brimble, Annapurna Poduri
ObjectiveTo delineate the comprehensive phenotypic spectrum of SYNGAP1‐related disorder in a large patient cohort aggregated through a digital registry.MethodsWe obtained de‐identified patient data from an online registry. Data were extracted from uploaded medical records. We reclassified all SYNGAP1 variants using American College of Medical Genetics criteria and included patients with pathogenic/likely
-
Effect of levodopa on pathological gait in Dravet syndrome: A randomized crossover trial using three‐dimensional gait analysis Epilepsia (IF 5.6) Pub Date : 2024-03-12 Takeshi Suzuki, Jun Natsume, Yuji Ito, Tadashi Ito, Koji Noritake, Fumie Kinoshita, Tatsuya Fukasawa, Takeshi Tsuji, Kazuya Itomi, Hirokazu Kurahashi, Kazuo Kubota, Tohru Okanishi, Shinji Saitoh, Hideshi Sugiura, Hirohisa Watanabe, Yoshiyuki Takahashi, Hiroyuki Kidokoro
ObjectiveIndividuals with Dravet syndrome (DS) exhibit progressive gait disturbance. No quantitative studies have been conducted to evaluate the effectiveness of medication for gait disturbance. Therefore, the aim of this study was to evaluate the effectiveness of levodopa for pathological gait in people with DS using three‐dimensional gait analysis (3DGA).MethodsNine individuals with DS, ages 6–20
-
A comprehensive systematic literature review of the burden of illness of Lennox–Gastaut syndrome on patients, caregivers, and society Epilepsia (IF 5.6) Pub Date : 2024-03-08 J. Helen Cross, Arturo Benítez, Jeannine Roth, J. Scott Andrews, Drishti Shah, Emma Butcher, Aimee Jones, Joseph Sullivan
Fully elucidating the burden that Lennox–Gastaut syndrome (LGS) places on individuals with the disease and their caregivers is critical to improving outcomes and quality of life (QoL). This systematic literature review evaluated the global burden of illness of LGS, including clinical symptom burden, care requirements, QoL, comorbidities, caregiver burden, economic burden, and treatment burden (PROSPERO
-
Delays in the diagnosis and surgical treatment of drug‐resistant epilepsy: A cohort study Epilepsia (IF 5.6) Pub Date : 2024-03-08 Justin M. Campbell, Samantha Yost, Diwas Gautam, Alysha Herich, David Botros, Mason Slaughter, Michael Chodakiewitz, Amir Arain, Angela Peters, Sindhu Richards, Blake Newman, Brian Johnson, Shervin Rahimpour, Ben Shofty
ObjectiveDelay in referral for epilepsy surgery of patients with drug‐resistant epilepsy (DRE) is associated with decreased quality of life, worse surgical outcomes, and increased risk of sudden unexplained death in epilepsy (SUDEP). Understanding the potential causes of delays in referral and treatment is crucial for optimizing the referral and treatment process. We evaluated the treatment intervals
-
Transient postictal dysphagia in older adults with focal structural epilepsy Epilepsia (IF 5.6) Pub Date : 2024-03-08 Sriramya Lapa, Anna Schwingshackl, Ulrike Frank, Felix Rosenow, Catrin Mann, Adam Strzelczyk
ObjectiveSeizures can cause transient neurological symptoms, such as hemiparesis and aphasia. However, temporary swallowing changes leading to postictal dysphagia have not been previously described. Therefore, this study evaluated the presence of swallowing disorders following seizure. In addition, dysphagia severity and duration of any recovery from dysphagic symptoms were investigated.MethodsThe
-
A global update on cenobamate based on real-world experience in over 100 000 patients Epilepsia (IF 5.6) Pub Date : 2024-03-06 Louis Ferrari, William E. Rosenfeld, Marc Kamin
Since cenobamate's launch in 2020, more than 100 000 patients have been treated with the medication worldwide. Here, we provide an important update to the epilepsy community on real-world experience with cenobamate almost 4 years post-launch. When a new anti-seizure medication (ASM) is approved, postmarketing data provide health care professionals with a valuable source of information for large numbers