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Evaluation of the first Candida auris isolates reported from Türkiye in terms of identification by various methods and susceptibility to antifungal drugs Indian J. Med. Microbiol. (IF 1.6) Pub Date : 2024-04-25 Gonca Erkose Genc, Ilvana Caklovica Kucukkaya, Selda Komec, Ilke Toker Onder, Oyku Toptas, Leyla Teke, Deniz Turan, Gokhan Aygun, Dolunay Gulmez, Sevtap Arikan Akdagli, Zayre Erturan
is increasingly being isolated from patients all over the world. It has five clades. In this study, it was aimed to compare the results of biochemical tests obtained using different methods and the antifungal susceptibility profiles of strains isolated from the first seven cases reported in Türkiye, and evaluate whether this information could be useful as preliminary data in determining the clade of
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Comparative performance of biofire pneumonia panel and standard culture-based methods for diagnosing pneumonia in critically ill patients: Impact on antibiotic stewardship Indian J. Med. Microbiol. (IF 1.6) Pub Date : 2024-04-22 Barnali Kakati, Rajender Singh, Garima Mittal, Nupur Koul
Lower respiratory tract infections (LRTIs) are a common cause of morbidity and mortality worldwide. Accurate identification of the pathogens causing LRTIs is crucial for ensuring of diagnostic and antibiotic stewardship. The Biofire Pneumonia Panel (BFPP) is a molecular diagnostic test that allows rapid detection of various bacterial and viral pathogens. In this study, we compared the performance of
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Paeniclostridium sordellii causing liver abscess: A rare case report in India Indian J. Med. Microbiol. (IF 1.6) Pub Date : 2024-04-19 Srestha Mitra, Jai Bhagwan, Ashish William, Oves Siddiqui, Sonal Saxena
, an anaerobic bacterium, causes hepatic infections in alcoholics and post-surgery (liver transplantation). While liver and brain abscesses are rare, drainage procedures and targeted antibiotic therapy assisted by early microbiological diagnosis have reduced mortality rates. We report a rare case of pyogenic liver abscess caused by in India, the early diagnosis of which has led to life saving outcome
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Low-cost conventional PCR techniques enable simultaneous detection of bacterial sexually transmitted infections with enhanced sensitivity and specificity Indian J. Med. Microbiol. (IF 1.6) Pub Date : 2024-04-18 Devyashree Medhi, Ridip Dutta, Anisha Sarma, Vaishali Sarma, Baharul Islam, Ribjul Islam, Lahari Saikia
(NG), (CT) and (MH), the three most common treatable bacterial sexually transmitted infections (STIs) worldwide can lead to many complications if remain untreated. Screening of high-risk population with highly sensitive methods will lead to significant improvement in patient outcomes and will prevent downward transmission. The advantages of Polymerase chain reaction (PCR) based assay are not only high
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Malaria in travelers: Childhood vaccination and focus on endemic regions Indian J. Med. Microbiol. (IF 1.6) Pub Date : 2024-04-16 Azhagu Madhavan Sivalingam, Arjun Pandian, Raju Ramasubbu
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Quality assurance of SARS-CoV-2 testing laboratories during the pandemic period in India – An experience from a designated provider laboratory Indian J. Med. Microbiol. (IF 1.6) Pub Date : 2024-04-13 Vikas Manchanda, Oves Siddiqui, Kavita Meena, Anju Sharma, Sonal Saxena
Indian Council of Medical Research (ICMR) initiated an Inter-Laboratory Quality Control testing (ILQC) program for Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) testing. Under this program, SARS-CoV-2 testing laboratories across the country submit specimens to the assigned State Quality Control (SQCs) laboratories for ILQC testing. This study aimed to investigate the performance of public
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Analysis of clinical characteristics of infections caused by shewanella species Indian J. Med. Microbiol. (IF 1.6) Pub Date : 2024-04-06 Yu Li, Rong Qi, Hui Yang, Xiao-lu Zhang, Yan Wu, Bao-hua Huang, Qi Zhao, Yu-feng Gu
The Shewanella genus is a rare pathogen of marine origin. In recent years, there has been a continuous increase in infection cases caused by this bacterium, and we have observed the uniqueness of infections caused by this microorganism. This study conducted a retrospective analysis of the medical history and laboratory examination data of patients infected with the Shewanella genus over the past decade
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Antimicrobial susceptibility of Viridians Group of Streptococci isolated from infective endocarditis patients from 2018 to 2023 Indian J. Med. Microbiol. (IF 1.6) Pub Date : 2024-04-04 Naveena Jagadeesan, Kavitha Karur, Nandini M.P., Manjunath C.N., Prapulla Kumari N., Praveen Kumar H.D.
Viridans Group of Streptococci (VGS) are heterogeneous alpha hemolytic Streptococci that form commensal flora in the oral cavity, upper respiratory tract, gastrointestinal tract and female genital tract and are potential pathogens that can cause serious infections like infective endocarditis and bacteremia. Penicillin or Ceftriaxone is the recommended first line agent for definitive therapy of VGS
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A rare case report of liver masses caused by Actinomyces species Indian J. Med. Microbiol. (IF 1.6) Pub Date : 2024-04-04 Deorina Roully Gratia Siregar, Arthur Pohan Kawilarang, Deby Kusumaningrum, Marijam Purwanta
Actinomycosis is a rare infection caused by spp. Of all actinomycosis infections, only 5% of Hepatic Actinomycosis (HA) infection has been reported. This disease is often misdiagnosed as a malignancy. This case report presents a 45-year-old woman with diabetes, initially suspected of intrahepatic cholangiocarcinoma, but after careful tissue staining, we found the results supported HA infection.
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Genetic characterization of Toxoplasma gondii strains isolated from humans living in İzmir, Türkiye Indian J. Med. Microbiol. (IF 1.6) Pub Date : 2024-04-04 Muhammet Karakavuk, Hüseyin Can, Aygül Çeltik, Tuğba Karakavuk, Ceren Gül, Hüseyin Aytaç Erdem, Hüsnü Pullukçu, Meltem Taşbakan, Mehmet Sezai Taşbakan, Adnan Yüksel Gürüz, Mert Döşkaya, Aysu Değirmenci Döşkaya
is an obligate intracellular zoonotic parasite that can infect all warm-blooded animals, including humans. Currently, clinical findings of toxoplasmosis are being related to strains such as Type I genotype may cause high pathogenicity and Type II genotype causes a milder clinical presentation. We have showed in our previous that Type II genotype is the most frequent strain detected in stray cats and
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Peritoneal dialysis-associated peritonitis caused by Neisseria.sicca: A case report and literature review Indian J. Med. Microbiol. (IF 1.6) Pub Date : 2024-04-04 Mengshuang Zhang, XuZhan Zhang, Xin Yin, GuiXia Li, Tian Yang, Di Xie, Chen Chen
, a Gram-negative diplococcus commonly found in the nasopharynx as part of normal bacterial flora, is typically non-pathogenic but has been associated with various diseases including endocarditis, conjunctivitis, pneumonia and meningitis (Jeurissen et al., 2006; Kozlova et al., 2020; Alcid, 1980; Carter et al., 2007). In this report, we present a case of peritonitis in a patient undergoing peritoneal
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A retrospective analysis on seroprevalence of acute viral hepatitis observed among dengue patients attending a tertiary care centre in central India Indian J. Med. Microbiol. (IF 1.6) Pub Date : 2024-03-29 Rajeev Kumar Jain, Anamika Jain, Deepti Chaurasia, Rakesh Shrivastava, Garima Kapoor, Nagaraj Perumal, Ankita Agarwal
The present study was conducted retrospectively to assess the frequency of acute viral hepatitis among the clinically suspected dengue cases presented at our tertiary care centre during 2021. To determine the presence of acute viral hepatitis; Hepatitis A virus (HAV) and Hepatitis E virus (HEV) infections, 104 specimens were selected from the dengue-suspected clinical specimens received during 2021
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Utility of quantitative loop mediated isothermal amplification (qLAMP) assay for the diagnosis of invasive pneumococcal disease (IPD) Indian J. Med. Microbiol. (IF 1.6) Pub Date : 2024-03-28 Sreeram Chandra Murthy Peela, Sujatha Sistla
Quantitative LAMP (qLAMP) assay is one of the recent and emerging diagnostic tests for infectious diseases. Only a few studies exist comparing this assay with quantitative real-time PCR (qPCR) for the diagnosis of invasive pneumococcal disease (IPD). To compare the diagnostic performance of qLAMP assay with qPCR targeting autolysin gene for the diagnosis of invasive pneumococcal disease. Ninety six
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Antimicrobial efficacy of eravacycline against emerging extensively drug-resistant (XDR) Acinetobacter baumannii isolates Indian J. Med. Microbiol. (IF 1.6) Pub Date : 2024-03-26 Hitender Gautam, Shahid Raza, Jaya Biswas, Sarita Mohapatra, Seema Sood, Benu Dhawan, Arti Kapil, Bimal K. Das
Drug-resistant is an emerging threat. This study has been conducted to observe the efficacy of eravacycline along with the RND-efflux pump system. A cross-sectional study was done collecting 48 clinical isolates of MICs of 15 antibiotics were detected along with BMD of tigecycline and eravacycline. PCR products of drug-resistant regulatory genes were sequenced and analyzed. Of the total 48 Isolates
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Concentration dependent exposure of vancomycin and teicoplanin induces vanG regulon in Staphylococcus aureus Indian J. Med. Microbiol. (IF 1.6) Pub Date : 2024-03-23 Monalisha Hazarika, Jayalaxmi Wangkheimayum, Kathakali Nath, K. Melson Singha, Debadatta Dhar Chanda, Amitabha Bhattacharjee
Therapeutic options for staphylococcus infections have been raised due to the emergence of VISA and VRSA. Six isolates of of clinical origin which were previously confirmed to carry were selected for this study. Antimicrobial susceptibility was performed by disc diffusion method. Transcriptional expression of and showed down regulation against vancomycin and teicoplanin but expression was increased
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Recurrent sternal wound infection caused by Gordonia bronchialis after open heart surgery Indian J. Med. Microbiol. (IF 1.6) Pub Date : 2024-03-23 Desdemona Rasitha, Sheela Devi, Nirmal Kumar, Sanjay R Nair
is an aerobic gram-positive bacilli and also weakly acid fast. It requires a long incubation time and extensive biochemical reactions for identification. Therefore, use of broad-range polymerase chain reaction (PCR) for amplification of genes such as 16S rRNA or followed by sequencing or advanced techniques like MALDI-TOF MS is needed for identification. Here, we present a case of persistent sternal
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Comparative evaluation of Vitek®2 and broth microdilution method for colistin susceptibility testing of Gram-negative isolates from intensive care unit in a tertiary care hospital Indian J. Med. Microbiol. (IF 1.6) Pub Date : 2024-03-23 Thripthi Ananda, Vandana K.E., Chiranjay Mukhopadhyay
Colistin is the last resort treatment against resistant Gram-negative bacteria, necessitating reliable and rapid means for sensitivity testing of colistin. Automated systems like VITEK®2 are adopted to determine the minimum inhibitory concentration (MIC) due to easy usage. Broth microdilution (BMD) for colistin MIC was suggested by EUCAST and CLSI. To compare and evaluate colistin MIC by BMD and VITEK®2
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Influence of Hepatitis C virus genotype and other factors on the viral load Indian J. Med. Microbiol. (IF 1.6) Pub Date : 2024-03-19 Kuhu Chatterjee, Deepjyoti Kalita, Sangeeta Deka, Mithilesh Kumar Jha, Rohit Gupta, Balram Ji Omar, Pratima Gupta
Anti-HCV reactive subjects were selected and relevant data was collected. Viral load and genotype were determined for all patients and were divided into low (<800,000 IU/mL) and high viral load (>800,000 IU/mL). Correlation of viral load with parameters like age, gender, risk factors and genotype etc. was determined by binomial regression. Higher viral load was noted with genotype 4, males and high
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Keratitis due to Lasiodiplodia theobromae successfully treated with voriconazole: A case series from Assam Indian J. Med. Microbiol. (IF 1.6) Pub Date : 2024-03-16 Chaitali Konwar, Tapan Gogoi, Abhishikta Chakraborty, Vivek Nimje, Navonil Gogoi, Reema Nath
is a dematiaceous fungus which rarely causes keratitis and is mostly resistant to the commonly used antifungal drugs.
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Chronic sexually acquired reactive arthritis secondary to Chlamydiatrachomatis Indian J. Med. Microbiol. (IF 1.6) Pub Date : 2024-03-12 Arkendu Basu, Jaya Biswas, Saurabh Singh, Vishal Gupta, Benu Dhawan
Reactive arthritis is included in the spectrum of seronegative spondyloarthritides, occurring secondary to triggers of genitourinary and gastrointestinal tract infections. We describe two cases of sexually acquired reactive arthritis secondary to genital infection by , diagnosed by in-house polymerase chain reaction performed on the first void urine. Both patients were managed with a combined approach
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In vitro activity of the newly approved antimicrobial agent Cefiderocol against Carbapenem resistant Gram negative clinical isolates Indian J. Med. Microbiol. (IF 1.6) Pub Date : 2024-03-10 Himanshi Khanchandani, Madhulika Chaudhury, M Srihari Rao, N. Ramakrishna, B. Venkataramana, Abhijit Chaudhury
Carbapenem resistant Gram negative bacteria have emerged as priority pathogens in recent years. Cefiderocol is a siderophore cephalosporin licensed in 2019 with claimed activity against ESBL producing and carbapenem resistant bacteria with much better safety margin compared to colistin. The present study was undertaken to assess the in vitro activity of cefiderocol against carbapenem resistant clinical
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Lessons learned from an external quality assurance program in applying CLSI interpretive criteria for reporting piperacillin/tazobactam susceptibility Indian J. Med. Microbiol. (IF 1.6) Pub Date : 2024-03-09 Balaji Veeraraghavan, Yamuna Devi Bakthavatchalam, Rani Diana Sahni
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Utility of galactomannan diagnostic assay in rhino-orbito-cerebral mycosis in COVID-19 patients Indian J. Med. Microbiol. (IF 1.6) Pub Date : 2024-03-08 Kuhu Chatterjee, Juhi Taneja, Charu Agarwal, Jaseetha Sasidharan, Asim Das, Aparna Pandey
An increasing number of fungal infections were reported post COVID-19 and many of them were caused by fungi of mixed aetiologies. This study was carried out to assess the utility of serum galactomannan (GM) assay in establishing the etiology of acute rhino-orbito-cerebral mycosis caused by spp. Two serum samples were obtained from 41 suspected post COVID-19 rhino-orbito-cerebral mycosis patients to
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Challenges in management of Candida auris meningitis secondary to infected ventriculoperitoneal shunt – A case report Indian J. Med. Microbiol. (IF 1.6) Pub Date : 2024-03-08 Sowmya Sridharan, Aishwarya Govindaswamy, Adithyan Rajendran, Roopesh Kumar V.R.
Meningitis in patients with ventriculo-peritoneal shunt (VP shunt) caused by various species of have been widely described in literature. However, reports describing as a cause of meningitis is limited. In this case report we describe a case of multidrug resistant meningitis secondary to VP shunt infection successfully treated with intrathecal amphotericin B deoxycholate and intravenous liposomal amphotericin
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Integron distribution and relationship to antimicrobial resistance in E. coli isolated from blood culture Indian J. Med. Microbiol. (IF 1.6) Pub Date : 2024-03-06 Sedef Zeliha Öner, Esra Karaday, Ahmet Çalışkan, Melek Demir, Hande Şenol, İlknur Kaleli
The aim of this study was to evaluate the distribution of integrons in strains of E. coli isolated from blood culture and the relationship between integrons and antimicrobial resistance. The study included 100 E. coli strains sent to the Medical Microbiology Laboratory from different clinics between September 2022 and June 2023. Antibiotic susceptibility was evaluated according to the European Committee
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An outbreak of acute hemorrhagic conjunctivitis due to Coxsackievirus A24 in a residential school, Naharlagun, Arunachal Pradesh: July 2023 Indian J. Med. Microbiol. (IF 1.6) Pub Date : 2024-03-05 Pallavi Boro, Tojum Gongo, Kimo Ori, Yompe Kamki, Nyai Ete, Moji Jini, Lobsang Jampa, Saurav Jyoti Patgiri, Neelanjana Sarmah, Aktarul Islam Siddique, Chandra Kanta Bhattacharjee, Nargis K. Bali, Biswajyoti Borkakoty
An acute conjunctivitis outbreak was investigated at a residential school in Naharlagun, Arunachal Pradesh, Northeast India, in July 2023. We aimed to identify the etiological agent and assess any complications in follow-up cases. We used a structured questionnaire to record clinical findings and followed up with cases one-month post-conjunctivitis. Sixty-one cases were examined and eight conjunctival
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Approach towards surveillance-based diagnosis of acute respiratory illness in India: Expert recommendations Indian J. Med. Microbiol. (IF 1.6) Pub Date : 2024-03-03 Vikas Manchanda, Jayshree Muralidharan, Neeraj Nischal, Kshitij Aggarwal, Swati Gupta, Nivedita Gupta, Anoop Velayudhan, Harmanmeet Kaur, Megha Brijwal, Mala Chhabra, Rajlakshmi Vishwanathan, Rahul Dhodapkar, Sanjay K. Mahajan, Saumya Deol, Jerin C. Sekhar, Srestha Mitra, Sonal Saxena, Jyoti Kumar, Anju Garg, Rakesh Lodha, V. Ravi, Manish Soneja, Valsan Philip Verghese, Camilla Rodrigues
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Crohn’s Disease and Herpes Zoster: Being Mindful of Vaccination Indian J. Med. Microbiol. (IF 1.6) Pub Date : 2024-02-27 Osman Cagin Buldukoglu, Ruhsen Ocal, Serkan Ocal
Crohn’s disease is a chronic inflammatory disease of the gastrointestinal tract. Immunosuppressive therapy is the main treatment modality in Crohn’s disease. Herpes zoster (HZ), caused by Varicella-zoster virus, is a relatively common albeit burdensome clinical picture mainly affecting adult population with immunosuppressive status. In this paper, we aimed to report a Crohn’s disease patient with HZ
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Epidemiology, clinical profile, and outcomes of CSF-diversion catheter-related infections – Prospective cohort study results from a single quaternary neurosurgery referral centre Indian J. Med. Microbiol. (IF 1.6) Pub Date : 2024-02-21 Dinoop Korol Ponnambath, Ganesh Divakar, Jincy Mamachan, Shiny Biju, Kavita Raja, Mathew Abraham
Device-associated CNS infections is a major subgroup of healthcare associated CNS infections. Healthcare-associated ventriculitis or meningitis differs considerably from community-acquired meningitis in its epidemiology, pathogenesis, clinical presentation and management. This study aimed to identify the infection rates, the associated risk factors, and outcomes of these life-threatening infections
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Epidemiology and outcomes of infections during extracorporeal membrane oxygenation in adult patients with COVID-19 ARDS- A single center study Indian J. Med. Microbiol. (IF 1.6) Pub Date : 2024-02-19 Divya Rakesh Joshi, Ram Gopalakrishnan, C. Selvi, Nandini Sethuraman, V.R. Yamunadevi, V. Ramasubramanian, P. Senthur Nambi, M. Yogesh, Thangaraj Paul Ramesh
There is a scarcity of data regarding nosocomial infections in patients with COVID-19 treated with ECMO. This observational study from India aims to describe the epidemiology and microbiology of infections in patients with COVID-19 associated ECMO. This is an ambi-directional observational study of COVID-19 ECMO patients admitted from April 2021 to June 2022 in a tertiary care hospital. The total number
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Molecular characterization of enteropathogenic Escherichia coli isolated from patients with gastroenteritis in a tertiary referral hospital of northeast India Indian J. Med. Microbiol. (IF 1.6) Pub Date : 2024-02-15 Sayani Roy, Barnamoy Bhattacharjee, Pranab Behari Mazumder, Mohana Bhattacharjee, Debadatta Dhar, Amitabha Bhattacharjee
Diarrhoeal illness accounts for a high morbidity and mortality both in paediatric as well as adult groups and diarrhoeagenic occupies a top position as a causative agent of infectious diarrhoeal illness worldwide. The aim of the current investigation was to determine the virulence and pattern of antibiotic resistance of enteropathogenic, enterotoxigenic, and shiga toxigenic that are linked to diarrhoea
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Gastrointestinal PCR panel results and antibiotic use in acute gastroenteritis cases: How appropriate are we in our usage? Indian J. Med. Microbiol. (IF 1.6) Pub Date : 2024-02-10 Sinan Çetin, Enes Telli, Ahmet Melih Şahin, Mediha Uğur, Emsal Aydın, İlknur Şenel, Meltem Arzu Yetkin
We aimed to determine the pathogens detected by the Gastrointestinal (GI) PCR panel in patients with acute gastroenteritis (AGE), the evaluation of antibiotic use in these patients, and the investigation of the role of laboratory parameters in differentiating viral and bacterial etiologies. The demographic characteristics, GI PCR panel results, laboratory investigations, antibiotic usage, and appropriateness
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Antimicrobial resistance in genital Mycoplasmas infections Indian J. Med. Microbiol. (IF 1.6) Pub Date : 2024-02-03 Giulia Ciccarese, Gaetano Serviddio, Astrid Herzum, Francesco Drago
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Serial active surveillance cultures of children admitted to a medical pediatric intensive care unit of a tertiary care teaching hospital: A prospective observational study Indian J. Med. Microbiol. (IF 1.6) Pub Date : 2024-01-29 Ashish Agarwal, Muralidharan Jayashree, Archana Angrup, Manisha Biswal, K.C. Sudeep, Shankar Prasad, Arun Bansal, Karthi Nallasamy, Suresh Kumar Angurana
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Rapid characterization of carbapenem-resistant Enterobacterales by multiplex lateral flow assay and detection of ceftazidime-avibactam-aztreonam synergy Indian J. Med. Microbiol. (IF 1.6) Pub Date : 2024-01-26 R. Kalaivani, Arunava Kali, R. Surendran, T. Sujaritha, C.P. Ganesh Babu
The choice of antibiotics for treatment of Carbapenem-Resistant Enterobacterales (CRE) is increasing becoming limited due to co-expression of Metallo-beta-lactamases (MBL) along with other carbapenemases in these isolates. The study aimed to investigate the occurrence of CRE and to determine the in-vitro synergy and clinical outcomes of Ceftazidime-Avibactam and Aztreonam combination in CRE infections
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Influence of COVID-19 over seasonal influenza activity in southern India Indian J. Med. Microbiol. (IF 1.6) Pub Date : 2024-01-26 Ferdinamarie Sharmila, S. Muthamizhkumaran, Vimal Raj Ratchagadasse, Narayan Ramamurthy, Sujatha Sistla, Rahul Dhodapkar
Basic epidemiological data is urgently needed in order to ascertain the changes brought about by COVID-19 pandemic, and help researchers, clinicians, and policy makers in addressing these issues. Data on influenza positivity from 2009 to 2019 was collected from Regional Influenza laboratory, JIPMER. Being COVID testing centre we tested samples (2020–2023) from Tamilnadu and Pondicherry. All SARI samples
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Treatment challenges in the management of difficult-to-treat gram-positive infections: A consensus view apropos therapeutic role of novel anti-MRSA antibiotics, levonadifloxacin (IV) and alalevonadifloxacin (oral) Indian J. Med. Microbiol. (IF 1.6) Pub Date : 2024-01-21 Sanjith Saseedharan, Dilip Dubey, Ratender Kumar Singh, Kapil Zirpe, Anirban Hom Choudhuri, Dip Narayan Mukherjee, Neha Gupta, Shrikant Sahasrabudhe, Sachin Soni, Sudhir Kulkarni, Prashant Walse, Agam Chandravadan Vora, Jessy Thomas, Ashwini Tayade, Girish Bhadarke, Kamal Kishore, Yashesh Paliwal, Pratik Patil, Pavan Kumar Reddy, Vasant Nagvekar, Balaji Veeraraghavan
Treatment of antibiotic-resistant Gram-positive infections (GPIs), including methicillin-resistant (MRSA) is becoming increasingly difficult, particularly in patients with multiple co-morbidities who require antibiotics with greater safety and a consistent pharmacokinetic/pharmacodynamic (PK/PD) profile. Such difficult-to-treat GPIs are often associated with poor outcomes, extended hospital stay and
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Minimum inhibitory concentration of doxycycline for Vibrio parahaemolyticus Indian J. Med. Microbiol. (IF 1.6) Pub Date : 2024-01-18 Deyan Stratev, Rumyana Fasulkova
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Strategically reducing carbapenem-resistant Acinetobacter baumannii through PDCA cycle-driven antibiotic management Indian J. Med. Microbiol. (IF 1.6) Pub Date : 2024-01-18 Xuekun Nie, Minhua Lin, Shuanglin Xu, Lingling Zhang, Xiaohui Lin, Weiying Huang
With the escalating global challenge of antibiotic resistance, particularly the resistance rate of Acinetobacter baumannii, the need to rationalize carbapenem antibiotic use in clinical settings has become paramount. Our study tapped into a fishbone diagram to uncover the irrationalities in applying these antibiotics and highlight potential influencing factors. Based on these analyses, we initiated
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Delayed identification of treatment failure causes high levels of acquired drug resistance and less future drug options among HIV-1-infected South Indians Indian J. Med. Microbiol. (IF 1.6) Pub Date : 2024-01-13 Sathasivam Sivamalar, Selvamurthi Gomathi, Jayaseelan Boobalan, Pachamuthu Balakrishnan, Amrose Pradeep, Chithra A. Devaraj, Sunil Suhas Solomonl, Duraisamy Nallusamy, Devarajan Nalini, Varalakshmi Sureka, Shanmugam Saravanan
HIV-1 Drug Resistance Mutations (DRMs) among Immunological failure (IF) on NRTI based first-line regimens, Thymidine analogue (TA) - AZT & D4T and Non-Thymidine Analogue (NTA) -TDF; and predict viral drug susceptibility to gain vision about optimal treatment strategies for second-line. Cross-sectionally, 300 HIV-1 infected patients, failing first-line HAART were included. HIV-1 gene spanning 20–240
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Evaluation of T and B cell immunophenotyping and antibody response to Covid-19 vaccine: Comment Indian J. Med. Microbiol. (IF 1.6) Pub Date : 2024-01-11 Amnuay Kleebayoon, Viroj Wiwanitkit
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Salmonella enterica serovar Give causing brain abscess and bacteremia: A case report Indian J. Med. Microbiol. (IF 1.6) Pub Date : 2024-01-09 Sana Afreen, Pallab Ray, R. Muthuvel, Ashish Agarwal, Archana Angrup
Non-typhoidal Salmonellosis are an important cause of gastroenteritis and invasive disease in developing countries, with increase resistance and mortality in paediatric age group. We report here, a rare case of bacteremia and brain abscess in a 3year old female child with serovar Give as a causative organism.
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Community Acquired Sphingomonas paucimobilis: Instigator or an Innocent Bystander Indian J. Med. Microbiol. (IF 1.6) Pub Date : 2024-01-03 Drishti Sagar
is a rare cause of bacteremia. It can affect both healthy and immunocompromised individuals. Community acquired infections of this organism are more common than nosocomial ones. We report two cases of community acquired bacteremia-one in a healthy patient and other in a diabetic patient. Both presented with multiple episodes of loose stools, pain abdomen, vomiting, decreased oral intake and myalgia
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Blood borne infections and Hepatitis B virus immunization levels among medical students in India Indian J. Med. Microbiol. (IF 1.6) Pub Date : 2024-01-03 Anju Sharma, Vikas Manchanda, Aman Agarwal, Advitiya Kapoor, Sunil Kumar, Sonal Saxena
Medical students are actively involved in direct patient care during their training and subsequent medical practice, making them susceptible to acquiring blood-borne pathogens, including HBV. This study aimed to assess the occurrence of blood-borne infections and the Hepatitis B immunization status among medical students. Furthermore, it sought to identify gaps in risk assessment for blood-borne pathogens
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Being positive may not be perfect Indian J. Med. Microbiol. (IF 1.6) Pub Date : 2024-01-03 Shaoli Basu, Asmita Salvi, Anjali Shetty, Camilla Rodrigues
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A Novel Report of mycetoma with Spinal Spread due to Madurella fahalli from India Indian J. Med. Microbiol. (IF 1.6) Pub Date : 2024-01-02 Vinaykumar Hallur, Chandra Sekar Sirka, Mukund Sable, Madhusmita Sethy, Nerbadyswari Bag, Supriya Sahu, Malaya Sahoo, M.R. Shivaprakash, Madhuchhanda Das
Eumycetoma caused by a drug-resistant fungus, has never been reported in India. Here, we describe a fatal case of eumycetoma with spinal involvement due to for the first time in India.
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Lung abscess by Streptococcus intermedius: An unusual first case report from India Indian J. Med. Microbiol. (IF 1.6) Pub Date : 2024-01-02 Alfa A. Siji, Keerthana Sajikumar, Kiran Chawla, Rahul Magazine, Rajagopal KV
A unique case report, probably first case from India, of lung abscess caused by in a previously untreated patient with Type 2 diabetes mellitus is reported here. The patient presented with non-productive cough and right-sided chest pain. Microbiological evaluation confirmed the presence of and the patient responded positively to antibiotic therapy. This case highlights the fact that may act as pathogen
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Early detection, reactivation of cytomegalovirus DNA & immediate early (IE)-mRNA expression in hematopoietic stem cell-transplant patients Indian J. Med. Microbiol. (IF 1.6) Pub Date : 2023-12-19 Sangeeta Thomas, Santhosh Kumar Duraisamy, Rayaz Ahmed, Aby Abraham, Auro Vishwabandhya, Vikram Mathews, Alok Srivastava, Prasanna Samuel, Rajesh Kannangai, O.C. Abraham, Biju George, Asha Mary Abraham
Human cytomegalovirus (HCMV) reactivation is a major cause of morbidity and mortality among stem cell transplant recipients post-transplantation. HCMV immediate-early messenger RNA (IE-mRNA) was evaluated as marker of post-transplant HCMV reactivation in bone marrow transplant recipients. ology: An in-house real-time reverse transcriptase PCR targeting IE-mRNA was developed to estimate HCMV mRNA levels
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Epidemiology and antifungal susceptibility of fungal infections from 2018 to 2021 in Shandong, eastern China: A report from the SPARSS program Indian J. Med. Microbiol. (IF 1.6) Pub Date : 2023-12-05 Mengyuan Wang, Chunyan Zhang, Zheng Li, Bing Ji, Sijin Man, Maoli Yi, Renzhe Li, Mingju Hao, Shifu Wang
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Evaluation of different linezolid susceptibility testing methods and detection of linezolid resistance gene (cfr) in staphylococcal isolates Indian J. Med. Microbiol. (IF 1.6) Pub Date : 2023-12-02 Sudarsan Bagavane Nandivarmane, Meerabai Manoharan, Madhan Sugumar, Sujatha Sistla
Linezolid is an effective oxazolidinone antibiotic against multi resistant Gram-positive organisms. Linezolid resistance is an emerging problem and some controversy exists about the reliability of different phenotypic methods of linezolid susceptibility testing. Fifty isolates each of methicillin resistant (MRSA) and were tested for linezolid susceptibility using Kirby-Bauer disc diffusion, E-test
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Neisseria mucosa: A not so Benign Culprit of urinary tract infection: A case report Indian J. Med. Microbiol. (IF 1.6) Pub Date : 2023-12-01 Sukriti Yadav, Sapna Pahil, Mani Bhushan Kumar, Ritin Mohindra, Balvinder Mohan, Neelam Taneja
is saprophytic human commensal but reported as a causative agent in a couple of urinary tract infections [UTI] in susceptible individuals. In the present case, a young girl with long standing neurological problems presented with bladder outlet obstruction and fever. Her urine culture yielded which was susceptible to broad spectrum penicillins, aminoglycosides, cephalosporins, ciprofloxacin, and azithromycin
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Effect of Klebsiella-specific phage on multidrug-resistant Klebsiella pneumoniae- an experimental study Indian J. Med. Microbiol. (IF 1.6) Pub Date : 2023-11-28 Somya Shree, Ethel Suman, Himani Kotian, S. Harsha Paul, Suchitra Shenoy M
The objective of this study was to study the effect of Klebsiella-specific phage isolated from sewage with and without the combination of antibiotics (imipenem) on the growth of clinical isolates of multidrug-resistant by time-kill assay and also to study the effect of bacteriophage and bacteriophage-antibiotic (imipenem) combination on biofilm production. A total of 40 MDR isolates were used. Klebsiella-specific
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Mycobacterium abscessus endocarditis post cardiac cathetrisation-a case report and review of 25 cases (2001–2023) Indian J. Med. Microbiol. (IF 1.6) Pub Date : 2023-11-26 Vithiya G, P. Shunmuga Sundaram
47 year male underwent percutaneous transluminal coronary angioplasty elsewhere, developed fever after two days, and treated empirically in various hospitals for the subsequent two months. Echocardiography showed vegetation in aortic valve and blood cultures were negative. He was then diagnosed as a case of endocarditis due to in our centre by repeated positive blood cultures. After treatment with
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Diptheroids can cause nosocomial UTI and be multidrug resistant: A case report of Corynebacterium striatum, first from India Indian J. Med. Microbiol. (IF 1.6) Pub Date : 2023-11-18 Mani Bhushan Kumar, Sapna Pahil, Sukriti Yadav, Karalanglin Tiewsoh, Thakurvir Singh, Balvinder Mohan, Neelam Taneja
Gram positive bacilli in the urine are usually dismissed as contaminants in urine specimens as these are commensal flora of skin and mucous membranes. species were misidentified in the past due to complex biochemicals but the advent of modern diagnostics has made their identification quicker and accurate. species have recently emerged as pathogens of nosocomial outbreak potential. has been identified
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Molecular detection of antimalarial resistance in Plasmodium vivax isolates from a tertiary care setting in Puducherry Indian J. Med. Microbiol. (IF 1.6) Pub Date : 2023-11-11 Pheba Stanley, Nonika Rajkumari, Monika Sivaradjy
The study was aimed at detecting the mutation patterns in the drug targets in that confer resistance to the common antimalarial agents used in India. A total of 27 isolates collected from whole blood samples over a three year period were subjected to PCR amplification followed by sequencing of the genes , , and which serve as the molecular targets to detect resistance to chloroquine, pyrimethamine
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Corrigendum to “Serological profile of patients suspected with non-scrub typhus rickettsioses” [Indian J Med Microbiol 46 November–December 2023 100471] Indian J. Med. Microbiol. (IF 1.6) Pub Date : 2023-11-10 Chandan Kumar Thakur, E.V. Vinayaraj, Tanu Sagar, Bimal Kumar Das, Sushil Kumar Kabra, Naveet Wig, Rama Chaudhry
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FIA (fluorescent immunoassay) test in Dengue Indian J. Med. Microbiol. (IF 1.6) Pub Date : 2023-11-10 Amnuay Kleebayoon, Viroj Wiwanitkit
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Comparison of B1 and RE 529 gene targets by real time PCR and LAMP assay for diagnosis of toxoplasmosis in pregnant females Indian J. Med. Microbiol. (IF 1.6) Pub Date : 2023-11-02 Priya Datta, Puja Garg, Divya Rattan, Rashmi Bagga, Minakshi Rohilla, Sumeeta Khurana, Rakesh Sehgal
The aim of this study is to accurately diagnose the presence of toxoplasmosis in pregnant women. In this study we evaluated two gene targets and using two different molecular methods i.e., real-time PCR and LAMP. A total of 150 blood samples were collected from pregnant women attending the PGIMER outpatient clinic. The serum and Buffy layer were extracted and various serological (ELISA) and molecular
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Bacillus licheniformis bloodstream infections associated with oral probiotic administration: Two case reports Indian J. Med. Microbiol. (IF 1.6) Pub Date : 2023-11-01 Qi Zou, Meng Cai, Yunjian Hu, Chunyue Ge, Xin Wang, Ran Duan
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Real-time loop-mediated isothermal amplification for the detection of Giardia duodenalis in fecal specimens Indian J. Med. Microbiol. (IF 1.6) Pub Date : 2023-11-01 Sumeeta Khurana, Chayan Sharma, Sucheta Guleria, Abhishek Mewara, Usha Dutta
Giardiasis is a leading cause of subacute or chronic diarrhoea and is frequently associated with impaired physical, cognitive and psychosocial development, especially in children. The diagnosis relies mainly on the microscopic evaluation of stool specimens that have a low sensitivity. In contrast, molecular advancements like the polymerase chain reaction and Real-time loop-mediated isothermal amplification