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Association between epigenetic age and type 2 diabetes mellitus or glycemic traits: A longitudinal twin study Aging Cell (IF 7.8) Pub Date : 2024-04-25 Ke Miao, Xuanming Hong, Weihua Cao, Jun Lv, Canqing Yu, Tao Huang, Dianjianyi Sun, Chunxiao Liao, Yuanjie Pang, Runhua Hu, Zengchang Pang, Min Yu, Hua Wang, Xianping Wu, Yu Liu, Wenjing Gao, Liming Li
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Neuronal microstructural changes in the human brain are associated with neurocognitive aging Aging Cell (IF 7.8) Pub Date : 2024-04-24 Kavita Singh, Stephanie Barsoum, Kurt G. Schilling, Yang An, Luigi Ferrucci, Dan Benjamini
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The impact of the senescent microenvironment on tumorigenesis: Insights for cancer therapy Aging Cell (IF 7.8) Pub Date : 2024-04-22 Wenqiang Zhang, Kexin Zhang, Junfeng Shi, Hongyan Qiu, Chengxia Kan, Yujie Ma, Ningning Hou, Fang Han, Xiaodong Sun
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Downregulation of PLIN2 in human dermal fibroblasts impairs mitochondrial function in an age-dependent fashion and induces cell senescence via GDF15 Aging Cell (IF 7.8) Pub Date : 2024-04-22 Antonio Chiariello, Luca Rossetti, Sabrina Valente, Gianandrea Pasquinelli, Manuela Sollazzo, Luisa Iommarini, Anna Maria Porcelli, Monica Tognocchi, Giuseppe Conte, Aurelia Santoro, Katarzyna M. Kwiatkowska, Paolo Garagnani, Stefano Salvioli, Maria Conte
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Epigenetic age oscillates during the day Aging Cell (IF 7.8) Pub Date : 2024-04-19 Karolis Koncevičius, Akhil Nair, Aušrinė Šveikauskaitė, Agnė Šeštokaitė, Auksė Kazlauskaitė, Audrius Dulskas, Artūras Petronis
Since their introduction, epigenetic clocks have been extensively used in aging, human disease, and rejuvenation studies. In this article, we report an intriguing pattern: epigenetic age predictions display a 24‐h periodicity. We tested a circadian blood sample collection using 17 epigenetic clocks addressing different aspects of aging. Thirteen clocks exhibited significant oscillations with the youngest
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NMR metabolomic modeling of age and lifespan: A multicohort analysis Aging Cell (IF 7.8) Pub Date : 2024-04-18 Chung-Ho E. Lau, Maria Manou, Georgios Markozannes, Mika Ala-Korpela, Yoav Ben-Shlomo, Nish Chaturvedi, Jorgen Engmann, Aleksandra Gentry-Maharaj, Karl-Heinz Herzig, Aroon Hingorani, Marjo-Riitta Järvelin, Mika Kähönen, Mika Kivimäki, Terho Lehtimäki, Saara Marttila, Usha Menon, Patricia B. Munroe, Saranya Palaniswamy, Rui Providencia, Olli Raitakari, Amand Floriaan Schmidt, Sylvain Sebert, Andrew
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DNA methylation-based telomere length is associated with HIV infection, physical frailty, cancer, and all-cause mortality Aging Cell (IF 7.8) Pub Date : 2024-04-17 Xiaoyu Liang, Bradley E. Aouizerat, Kaku So-Armah, Mardge H. Cohen, Vincent C. Marconi, Ke Xu, Amy C. Justice
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IgG1 glycosylation highlights premature aging in Down syndrome Aging Cell (IF 7.8) Pub Date : 2024-04-15 Bianca M. M. Streng, Julie Van Coillie, Joanne G. Wildenbeest, Rob S. Binnendijk, Gaby Smits, Gerco den Hartog, Wenjun Wang, Jan Nouta, Federica Linty, Remco Visser, Manfred Wuhrer, Gestur Vidarsson, Louis J. Bont
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Autophagy gene expression in skeletal muscle of older individuals is associated with physical performance, muscle volume and mitochondrial function in the study of muscle, mobility and aging (SOMMA) Aging Cell (IF 7.8) Pub Date : 2024-04-16 Paul M. Coen, Zhiguang Huo, Gregory J. Tranah, Haley N. Barnes, Xiping Zhang, Christopher A. Wolff, Kevin Wu, Peggy M. Cawthon, Russell T. Hepple, Frederico G. S. Toledo, Daniel S. Evans, Olaya Santiago-Fernández, Ana Maria Cuervo, Stephen B. Kritchevsky, Anne B. Newman, Steven R. Cummings, Karyn A. Esser
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Featured Cover Aging Cell (IF 7.8) Pub Date : 2024-04-16 Mariann M. Gabrawy, Reyhan Westbrook, Austin King, Nick Khosravian, Neeraj Ochaney, Tagide DeCarvalho, Qinchuan Wang, Yuqiong Yu, Qiao Huang, Adam Said, Michael Abadir, Cissy Zhang, Pratik Khare, Jennifer E. Fairman, Anne Le, Ginger L. Milne, Fernando J. Vonhoff, Jeremy D. Walston, Peter M. Abadir
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Additional Cover Aging Cell (IF 7.8) Pub Date : 2024-04-16 Eva Roig‐Rosello, Guila Dayan, Simone Bovio, Patricia Manissier, Elisabeth Errazuriz, Patricia Rousselle
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Diurnal expression of Dgat2 induced by time‐restricted feeding maintains cardiac health in the Drosophila model of circadian disruption Aging Cell (IF 7.8) Pub Date : 2024-04-15 Yiming Guo, Farah Abou Daya, Hiep Dinh Le, Satchidananda Panda, Girish C. Melkani
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Aged‐vascular niche hinders osteogenesis of mesenchymal stem cells through paracrine repression of Wnt‐axis Aging Cell (IF 7.8) Pub Date : 2024-04-05 Viviane Fleischhacker, Filip Milosic, Marko Bricelj, Kristina Kührer, Katharina Wahl‐Figlash, Patrick Heimel, Andreas Diendorfer, Eleonora Nardini, Irmgard Fischer, Herbert Stangl, Peter Pietschmann, Matthias Hackl, Roland Foisner, Johannes Grillari, Markus Hengstschläger, Selma Osmanagic‐Myers
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Progeria‐based vascular model identifies networks associated with cardiovascular aging and disease Aging Cell (IF 7.8) Pub Date : 2024-04-05 Mzwanele Ngubo, Zhaoyi Chen, Darin McDonald, Rana Karimpour, Amit Shrestha, Julien Yockell‐Lelièvre, Aurélie Laurent, Ojong Tabi Ojong Besong, Eve C. Tsai, F. Jeffrey Dilworth, Michael J. Hendzel, William L. Stanford
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Identification of prospective aging drug targets via Mendelian randomization analysis Aging Cell (IF 7.8) Pub Date : 2024-04-04 Rui Mao, Ji Li, Wenqin Xiao
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Aging and intraocular pressure homeostasis in mice Aging Cell (IF 7.8) Pub Date : 2024-04-03 Guorong Li, Joseph van Batenburg‐Sherwood, Babak N. Safa, Nina Sara Fraticelli Guzmán, Andrea Wilson, Mohammad Reza Bahrani Fard, Kevin Choy, Michael L. de Ieso, J. Serena Cui, Andrew J. Feola, Tara Weisz, Megan Kuhn, Catherine Bowes Rickman, Sina Farsiu, C. Ross Ethier, W. Daniel Stamer
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Methylation entropy landscape of Chinese long‐lived individuals reveals lower epigenetic noise related to human healthy aging Aging Cell (IF 7.8) Pub Date : 2024-04-03 Hao‐Tian Wang, Fu‐Hui Xiao, Zong‐Liang Gao, Li‐Yun Guo, Li‐Qin Yang, Gong‐Hua Li, Qing‐Peng Kong
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It is time to explore the impact of length of gestation and fetal health on the human lifespan Aging Cell (IF 7.8) Pub Date : 2024-04-01 Zhuo Yu, Yushan Dong, Yuhan Chen, Lotfi Aleya, Yinhuan Zhao, Lan Yao, Weikuan Gu
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Selective targeting of dipeptidyl‐peptidase 4 (DPP‐4) positive senescent chondrocyte ameliorates osteoarthritis progression Aging Cell (IF 7.8) Pub Date : 2024-04-01 Du Hyun Ro, Gun Hee Cho, Ji Yoon Kim, Seong Ki Min, Ha Ru Yang, Hee Jung Park, Sun Young Wang, You Jung Kim, Myung Chul Lee, Hyun Cheol Bae, Hyuk‐Soo Han
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U‐shaped association between sleep duration and biological aging: Evidence from the UK Biobank study Aging Cell (IF 7.8) Pub Date : 2024-04-01 Xuanyang Wang, Xuemin Yan, Mengdi Li, Licheng Cheng, Xiang Qi, Jia Zhang, Sijia Pan, Xiaoqing Xu, Wei Wei, Ying Li
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Subcellular structure, heterogeneity, and plasticity of senescent cells Aging Cell (IF 7.8) Pub Date : 2024-03-30 Thais Cardoso Bitencourt, Jose Eduardo Vargas, Andrew Oliveira Silva, Lucas Rosa Fraga, Eduardo Filippi-Chiela
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Prevention of age‐related neuromuscular junction degeneration in sarcopenia by low‐magnitude high‐frequency vibration Aging Cell (IF 7.8) Pub Date : 2024-03-27 Zhengyuan Bao, Can Cui, Chaoran Liu, Yufeng Long, Ronald Man Yeung Wong, Senlin Chai, Ling Qin, Clinton Rubin, Benjamin Hon Kei Yip, Zhihong Xu, Qing Jiang, Simon Kwoon‐Ho Chow, Wing‐Hoi Cheung
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Hungry for biomarkers of aging Aging Cell (IF 7.8) Pub Date : 2024-03-27 Nathan K. LeBrasseur
Greater insights into biological mechanisms (hallmarks) of aging, their associations with aging-related diseases and disabilities, and early evidence that they can be modified by intervention have generated intense interest in testing the geroscience hypothesis; that is, interventions targeting hallmarks of aging will delay or even prevent age-related diseases and disabilities. This innovative and
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Human α‐synuclein overexpression upregulates SKOR1 in a rat model of simulated nigrostriatal ageing Aging Cell (IF 7.8) Pub Date : 2024-03-26 Noelia Morales‐Prieto, Rebekah Bevans, Adam O'Mahony, Aaron Barron, Conor Giles Doran, Erin McCarthy, Ruth M. Concannon, Susan R. Goulding, Cathal M. McCarthy, Louise M. Collins, Aideen M. Sullivan, Gerard W. O'Keeffe
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Combinatorial transcriptomic and genetic dissection of insulin/IGF‐1 signaling‐regulated longevity in Caenorhabditis elegans Aging Cell (IF 7.8) Pub Date : 2024-03-26 Seokjin Ham, Sieun S. Kim, Sangsoon Park, Hyunwoo C. Kwon, Seokjun G. Ha, Yunkyu Bae, Gee‐Yoon Lee, Seung‐Jae V. Lee
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Humanin variant P3S is associated with longevity in APOE4 carriers and resists APOE4‐induced brain pathology Aging Cell (IF 7.8) Pub Date : 2024-03-23 Brendan Miller, Su‐Jeong Kim, Kevin Cao, Hemal H. Mehta, Neehar Thumaty, Hiroshi Kumagai, Tomomitsu Iida, Cassandra McGill, Christian J. Pike, Kamila Nurmakova, Zachary A. Levine, Patrick M. Sullivan, Kelvin Yen, Nilüfer Ertekin‐Taner, Gil Atzmon, Nir Barzilai, Pinchas Cohen
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Age‐related cholesterol and colorectal cancer progression: Validating squalene epoxidase for high‐risk cases Aging Cell (IF 7.8) Pub Date : 2024-03-22 Soo Young Jun, Hyang Ran Yoon, Ji‐Yong Yoon, Jeong‐Ju Lee, Ji Yeon Kim, Jin‐Man Kim, Nam‐Soon Kim
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Effect of long‐term caloric restriction on telomere length in healthy adults: CALERIE™ 2 trial analysis Aging Cell (IF 7.8) Pub Date : 2024-03-20 Waylon J. Hastings, Qiaofeng Ye, Sarah E. Wolf, Calen P. Ryan, Sai Krupa Das, Kim M. Huffman, Michael S. Kobor, William E. Kraus, Julia L. MacIsaac, Corby K. Martin, Susan B. Racette, Leanne M. Redman, Daniel W. Belsky, Idan Shalev
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Aging‐affiliated post‐translational modifications of skeletal muscle myosin affect biochemical properties, myofibril structure, muscle function, and proteostasis Aging Cell (IF 7.8) Pub Date : 2024-03-20 Clara L. Neal, William A. Kronert, Jared Rafael T. Camillo, Jennifer A. Suggs, Tom Huxford, Sanford I. Bernstein
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Genetic and pharmacological modulation of lamin A farnesylation determines its function and turnover Aging Cell (IF 7.8) Pub Date : 2024-03-20 Mattheus Xing Rong Foo, Peh Fern Ong, Zi Xuan Yap, Martina Maric, Christopher Jue Shi Bong, Peter Dröge, Brian Burke, Oliver Dreesen
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Stem cell secretome treatment improves whole‐body metabolism, reduces adiposity, and promotes skeletal muscle function in aged mice Aging Cell (IF 7.8) Pub Date : 2024-03-19 Zachary J. Fennel, Paul‐Emile Bourrant, Anu Susan Kurian, Jonathan J. Petrocelli, Naomi M. M. P. de Hart, Elena M. Yee, Sihem Boudina, Hans S. Keirstead, Gabrielle Nistor, Scott A. Greilach, Nicole C. Berchtold, Thomas E. Lane, Micah J. Drummond
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MicroRNA‐7 deficiency ameliorates d‐galactose‐induced aging in mice by regulating senescence of Kupffer cells Aging Cell (IF 7.8) Pub Date : 2024-03-18 Ya Wang, Hui Qiu, Shipeng Chen, Dongmei Li, Xu Zhao, Mengmeng Guo, Nana Li, Chao Chen, Ming Qin, Ya Zhou, Daimin Xiao, Juanjuan Zhao, Lin Xu
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Mitophagy defect mediates the aging‐associated hallmarks in Hutchinson–Gilford progeria syndrome Aging Cell (IF 7.8) Pub Date : 2024-03-14 Yingying Sun, Le Xu, Yi Li, Shunze Jia, Gang Wang, Xufeng Cen, Yuyan Xu, Zhongkai Cao, Jingjing Wang, Ning Shen, Lidan Hu, Jin Zhang, Jianhua Mao, Hongguang Xia, Zhihong Liu, Xudong Fu
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The aged microenvironment impairs BCL6 and CD40L induction in CD4+ T follicular helper cell differentiation Aging Cell (IF 7.8) Pub Date : 2024-03-14 Jacob S. Fisher, Irene Adán‐Barrientos, Naveen R. Kumar, Jessica N. Lancaster
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Dual treatment with kynurenine pathway inhibitors and NAD+ precursors synergistically extends life span in Drosophila Aging Cell (IF 7.8) Pub Date : 2024-03-13 Mariann M. Gabrawy, Reyhan Westbrook, Austin King, Nick Khosravian, Neeraj Ochaney, Tagide DeCarvalho, Qinchuan Wang, Yuqiong Yu, Qiao Huang, Adam Said, Michael Abadir, Cissy Zhang, Pratik Khare, Jennifer E. Fairman, Anne Le, Ginger L. Milne, Fernando J. Vonhoff, Jeremy D. Walston, Peter M. Abadir
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Endothelial‐specific telomerase inactivation causes telomere‐independent cell senescence and multi‐organ dysfunction characteristic of aging Aging Cell (IF 7.8) Pub Date : 2024-03-13 Zhanguo Gao, Rafael Bravo Santos, Joseph Rupert, Rachel Van Drunen, Yongmei Yu, Kristin Eckel‐Mahan, Mikhail G. Kolonin
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Dermal stiffness governs the topography of the epidermis and the underlying basement membrane in young and old human skin Aging Cell (IF 7.8) Pub Date : 2024-03-12 Eva Roig-Rosello, Guila Dayan, Simone Bovio, Patricia Manissier, Elisabeth Errazuriz, Patricia Rousselle
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Featured Cover Aging Cell (IF 7.8) Pub Date : 2024-03-12 Yoon Seon Lee, Yeoung‐Hyun Park, Geumbit Hwang, Hyejin Seo, Si Hyoung Ki, Shengfeng Bai, Chul Son, Seong Min Roh, Su‐Jin Park, Dong‐Seol Lee, Ji‐Hyun Lee, You‐Mi Seo, Won Jun Shon, Daehyun Jeon, Mi Jang, Sahng G. Kim, Byoung‐Moo Seo, Gene Lee, Joo‐Cheol Park
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Additional Cover Aging Cell (IF 7.8) Pub Date : 2024-03-12 Chaweewan Sirakawin, Dongfa Lin, Ziyue Zhou, Xiaoxin Wang, Rhianne Kelleher, Shangyuan Huang, Weimiao Long, Andre Pires‐daSilva, Yu Liu, Jingjing Wang, Ilya A. Vinnikov
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Additional Cover Aging Cell (IF 7.8) Pub Date : 2024-03-12 Seungman Park, Thomas C. Laskow, Jingchun Chen, Prasun Guha, Buddhadeb Dawn, Deok‐Ho Kim
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Correction to: Akt2 ablation prolongs life span and improves myocardial contractile function with adaptive cardiac remodeling: role of Sirt1‐mediated autophagy regulation Aging Cell (IF 7.8) Pub Date : 2024-03-12
Ren J, Yang L, Zhu L, Xu X, Ceylan AF, Guo W, Yang J, Zhang Y. Aging Cell. 2017;16(5):976-987. doi: https://doi.org/10.1111/acel.12616. Epub 2017 Jul 5. The authors of the abovementioned paper noticed an error in Figure 1 as reported. During data analysis of lectin staining, several data points were mistakenly entered twice causing erroneously reported sample size, mean, and SEM. We have corrected
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Polr3b heterozygosity in mice induces both beneficial and deleterious effects on health during ageing with no effect on lifespan Aging Cell (IF 7.8) Pub Date : 2024-03-11 Gillian Borland, Stephen E. Wilkie, Jackie Thomson, Zhe Wang, Jennifer M. A. Tullet, Nazif Alic, Colin Selman
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Chronic TNF exposure induces glucocorticoid‐like immunosuppression in the alveolar macrophages of aged mice that enhances their susceptibility to pneumonia Aging Cell (IF 7.8) Pub Date : 2024-03-09 Katherine L. Kruckow, Elizabeth Murray, Elnur Shayhidin, Alexander F. Rosenberg, Dawn M. E. Bowdish, Carlos J. Orihuela
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A molecular index for biological age identified from the metabolome and senescence-associated secretome in humans Aging Cell (IF 7.8) Pub Date : 2024-03-07 Shruthi Hamsanathan, Tamil Anthonymuthu, Denise Prosser, Anna Lokshin, Susan L. Greenspan, Neil M. Resnick, Subashan Perera, Satoshi Okawa, Giri Narasimhan, Aditi U. Gurkar
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Integrin restriction by miR‐34 protects germline progenitors from cell death during aging Aging Cell (IF 7.8) Pub Date : 2024-03-07 Noam Perry, Racheli Braun, Aya Ben‐Hamo‐Arad, Diana Kanaan, Tal Arad, Lilach Porat‐Kuperstein, Toledano Hila
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Ercc1 DNA repair deficiency results in vascular aging characterized by VSMC phenotype switching, ECM remodeling, and an increased stress response Aging Cell (IF 7.8) Pub Date : 2024-03-07 Janette van der Linden, Sanne J. M. Stefens, José María Heredia‐Genestar, Yanto Ridwan, Renata M. C. Brandt, Nicole van Vliet, Isa de Beer, Bibi S. van Thiel, Herman Steen, Caroline Cheng, Anton J. M. Roks, A. H. Jan Danser, Jeroen Essers, Ingrid van der Pluijm
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Telomere length and micronuclei trajectories in APP/PS1 mouse model of Alzheimer's disease: Correlating with cognitive impairment and brain amyloidosis in a sexually dimorphic manner Aging Cell (IF 7.8) Pub Date : 2024-03-07 Xihan Guo, Jianfei Li, Yanmei Qi, Juanlin Chen, Minyan Jiang, Lina Zhu, Zetong Liu, Han Wang, Gongwu Wang, Xu Wang
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Plasma proteomic signature of human longevity Aging Cell (IF 7.8) Pub Date : 2024-03-05 Xiaojuan Liu, Gisli Thor Axelsson, Anne B. Newman, Bruce M. Psaty, Robert M. Boudreau, Chenkai Wu, Alice M. Arnold, Thor Aspelund, Thomas R. Austin, Julius M. Gardin, Kristin Siggeirsdottir, Russell P. Tracy, Robert E. Gerszten, Lenore J. Launer, Lori L. Jennings, Vilmundur Gudnason, Jason L. Sanders, Michelle C. Odden
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Epigenetic aging of human blood cells is influenced by the age of the host body Aging Cell (IF 7.8) Pub Date : 2024-03-05 Petter Holland, Mette Istre, Maryan M. Ali, Tobias Gedde‐Dahl, Jochen Buechner, Mari Wildhagen, Sonja H. Brunvoll, Steve Horvath, Shigemi Matsuyama, John Arne Dahl, Friedrich Stölzel, Arne Søraas
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Multi‐proteomic analyses of 5xFAD mice reveal new molecular signatures of early‐stage Alzheimer's disease Aging Cell (IF 7.8) Pub Date : 2024-03-04 Seulah Lee, Kuk‐In Jang, Hagyeong Lee, Yeon Suk Jo, Dayoung Kwon, Geuna Park, Sungwon Bae, Yang Woo Kwon, Jin‐Hyeok Jang, Yong‐Seok Oh, Chany Lee, Jong Hyuk Yoon
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The cellular bases of mobility from the Study of Muscle, Mobility and Aging (SOMMA) Aging Cell (IF 7.8) Pub Date : 2024-03-02 Steven R. Cummings, Paul M. Coen, Luigi Ferrucci
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Effects from medications on functional biomarkers of aging in three longitudinal studies of aging in Sweden Aging Cell (IF 7.8) Pub Date : 2024-03-01 Thaís Lopes De Oliveira, Bowen Tang, Ge Bai, Arvid Sjölander, Juulia Jylhävä, Deborah Finkel, Nancy L. Pedersen, Linda B. Hassing, Chandra A. Reynolds, Ida K. Karlsson, Sara Hägg
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Transcriptomic and intervention evidence reveals domestic dogs as a promising model for anti‐inflammatory investigation Aging Cell (IF 7.8) Pub Date : 2024-03-01 Min Zeng, Tong Zhou, Zhiyu Li, Guimei Li, Shurun Zhang, Lu Wang, Qing‐Guo Huang, Ju‐Dong Li, P. Nadeeshika Samarawickrama, Yonghan He, Guo‐Dong Wang
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Inhibition of 26S proteasome activity by α‐synuclein is mediated by the proteasomal chaperone Rpn14/PAAF1 Aging Cell (IF 7.8) Pub Date : 2024-02-28 Dajana Galka, Tariq T. Ali, Alexander Bast, Marie Niederleithinger, Ellen Gerhardt, Ryo Motosugi, Eri Sakata, Michael Knop, Tiago F. Outeiro, Blagovesta Popova, Gerhard H. Braus
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Enhanced TRPC3 transcription through AT1R/PKA/CREB signaling contributes to mitochondrial dysfunction in renal tubular epithelial cells in D‐galactose‐induced accelerated aging mice Aging Cell (IF 7.8) Pub Date : 2024-02-28 Bin Wang, Wenpei Yu, Weiguang Zhang, Min Zhang, Yue Niu, Xinye Jin, Jie Zhang, Ding Sun, Hao Li, Zehao Zhang, Qing Luo, Xiaowei Cheng, Jingxue Niu, Guangyan Cai, Xiangmei Chen, Yizhi Chen
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Epigenome‐wide analysis of frailty: Results from two European twin cohorts Aging Cell (IF 7.8) Pub Date : 2024-02-28 Jonathan K. L. Mak, Asmus Cosmos Skovgaard, Marianne Nygaard, Laura Kananen, Chandra A. Reynolds, Yunzhang Wang, Ralf Kuja‐Halkola, Ida K. Karlsson, Nancy L. Pedersen, Sara Hägg, Mette Soerensen, Juulia Jylhävä