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SNHG1 knockdown promotes osteogenic differentiation of hDFSCs through anti‐oxidative stress mediated by autophagy J. Cell. Physiol. (IF 5.6) Pub Date : 2024-04-23 Lidi Deng, Liping Wu, Dongru Chen, Yang Cao
The long noncoding RNA (lncRNA) small nucleolar RNA host gene 1 (SNHG1) plays a crucial role in tumorigenesis and is frequently employed as a prognostic biomarker. However, its involvement in the osteogenic differentiation of oral stem cells, particularly human dental follicle stem cells (hDFSCs), remains unclear. Our investigation revealed that the absence of SNHG1 enhances the osteogenic differentiation
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B cells and atherosclerosis: A HIV perspective J. Cell. Physiol. (IF 5.6) Pub Date : 2024-04-23 Laventa M. Obare, Rachel H. Bonami, Amanda C. Doran, Celestine N. Wanjalla
Atherosclerosis remains a leading cause of cardiovascular disease (CVD) globally, with the complex interplay of inflammation and lipid metabolism at its core. Recent evidence suggests a role of B cells in the pathogenesis of atherosclerosis; however, this relationship remains poorly understood, particularly in the context of HIV. We review the multifaceted functions of B cells in atherosclerosis, with
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Carboxymethylated Desmodium styracifolium polysaccharide reduces the risk of calcium oxalate kidney stone formation by inhibiting crystal adhesion and promoting crystal endocytosis J. Cell. Physiol. (IF 5.6) Pub Date : 2024-04-22 Zhi Wang, Li Liu, Yao‐Wang Zhao, Xin‐Yi Tong, Gu‐Hua Tang, Jian‐Ming Ouyang
The inhibition of cell surface crystal adhesion and an appropriate increase in crystal endocytosis contribute to the inhibition of kidney stone formation. In this study, we investigated the effects of different degrees of carboxymethylation on these processes. An injury model was established by treating human renal proximal tubular epithelial (HK‐2) cells with 98.3 ± 8.1 nm calcium oxalate dihydrate
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KLF13 promotes VSMCs phenotypic dedifferentiation by directly binding to the SM22α promoter J. Cell. Physiol. (IF 5.6) Pub Date : 2024-04-18 Xiaofan Yuan, Chuan Jiang, Yuzhou Xue, Fuqiang Guo, Minghao Luo, Lei Guo, Yang Gao, Tongling Yuan, Hui Xu, Hong Chen
Krüppel‐like factor 13 (KLF13), a zinc finger transcription factor, is considered as a potential regulator of cardiomyocyte differentiation and proliferation during heart morphogenesis. However, its precise role in the dedifferentiation of vascular smooth muscle cells (VSMCs) during atherosclerosis and neointimal formation after injury remains poorly understood. In this study, we investigated the relationship
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Leukotriene B4 signaling in diabetic ventricular arrhythmias J. Cell. Physiol. (IF 5.6) Pub Date : 2024-04-12 Ademuyiwa S. Aromolaran
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New paradigms in the study of the cholinergic system and metabolic diseases: Acetyl‐and‐butyrylcholinesterase J. Cell. Physiol. (IF 5.6) Pub Date : 2024-04-12 Juan David Villeda‐González, José Luis Gómez‐Olivares, Luis Arturo Baiza‐Gutman
Acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) are enzymes that belong to the neuromuscular cholinergic system, their main function is to hydrolyze the neurotransmitter acetylcholine (ACh), through their hydrolysis these enzymes regulate the neuronal and neuromuscular cholinergic system. They have recently attracted considerable attention due to the discovery of new enzymatic and nonenzymatic
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How to design a broad mindfulness program: One approach to introducing mindfulness to a STEM commumity within a university setting J. Cell. Physiol. (IF 5.6) Pub Date : 2024-04-12 Stefanie Alexander, Zer Vue, Landrew Sevel, Chia Vang, Kit Neikirk, Antentor Hinton, Kendra H. Oliver
Mindfulness has become popular in recent decades as a tool for psychological well‐being. However, mindfulness has yet to find a solid footing as a routine practice within the Science, Technology, Engineering, and Mathematics (STEM) field. Here, we discuss the design of an introductory mindfulness program that provides the STEM community with a broad overview of various mindfulness methods. We also
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Cover Image, Volume 239, Number 4, April 2024 J. Cell. Physiol. (IF 5.6) Pub Date : 2024-04-11 Antentor Hinton, Prasanna Katti, Margaret Mungai, Duane D. Hall, Olha Koval, Jianqiang Shao, Zer Vue, Edgar Garza Lopez, Rahmati Rostami, Kit Neikirk, Jessica Ponce, Jennifer Streeter, Brandon Schickling, Serif Bacevac, Chad Grueter, Andrea Marshall, Heather K. Beasley, Young Do Koo, Sue C. Bodine, Nayeli G. Reyes Nava, Anita M. Quintana, Long‐Sheng Song, Isabella M. Grumbach, Renata O. Pereira, Brian
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Cover Image, Volume 239, Number 4, April 2024 J. Cell. Physiol. (IF 5.6) Pub Date : 2024-04-11 Antentor Hinton, Prasanna Katti, Margaret Mungai, Duane D. Hall, Olha Koval, Jianqiang Shao, Zer Vue, Edgar Garza Lopez, Rahmati Rostami, Kit Neikirk, Jessica Ponce, Jennifer Streeter, Brandon Schickling, Serif Bacevac, Chad Grueter, Andrea Marshall, Heather K. Beasley, Young Do Koo, Sue C. Bodine, Nayeli G. Reyes Nava, Anita M. Quintana, Long‐Sheng Song, Isabella M. Grumbach, Renata O. Pereira, Brian
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Elevated glucose promotes MMP13 and ADAMTS5 production by osteoarthritic chondrocytes under oxygenated but not hypoxic conditions J. Cell. Physiol. (IF 5.6) Pub Date : 2024-04-10 Lekha Jain, Scott M. Bolam, Paul Monk, Jacob T. Munro, Jade Tamatea, Nicola Dalbeth, Raewyn C. Poulsen
Type 2 diabetes is linked with increased incidence and severity of osteoarthritis. The purpose of this study was to determine the effect of extracellular glucose within the normal blood glucose and hyperglycemic range on catabolic enzyme production by chondrocytes isolated from osteoarthritic (OA) and macroscopically normal (MN) human cartilage under oxygenated (18.9% oxygen) and hypoxic (1% oxygen)
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The graduate school guide: How to prepare for the qualifying exam and assemble a thesis/graduate committee J. Cell. Physiol. (IF 5.6) Pub Date : 2024-04-10 Crystal D. Rogers, Annet Kirabo, Melanie McReynolds, Mariya T. Sweetwyne, Celestine Wanjalla, Jazmine Benjamin, Edith M. Williams, Jennifer A. Gaddy, Clintoria R. Williams, Steven M. Damo, Sandra A. Murray, Antentor Hinton
Qualifying exams and thesis committees are crucial components of a PhD candidate's journey. However, many candidates have trouble navigating these milestones and knowing what to expect. This article provides advice on meeting the requirements of the qualifying exam, understanding its format and components, choosing effective preparation strategies, retaking the qualifying exam, if necessary, and selecting
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Osteosarcoma cell death induced by innovative scaffolds doped with chemotherapeutics J. Cell. Physiol. (IF 5.6) Pub Date : 2024-04-09 Carmen Lanzillotti, Maria Rosa Iaquinta, Raffaella De Pace, Maria Mosaico, Simone Patergnani, Carlotta Giorgi, Marta Tavoni, Massimiliano Dapporto, Simone Sprio, Anna Tampieri, Monica Montesi, Fernanda Martini, Elisa Mazzoni
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circUSP13 facilitates the fast‐to‐slow myofiber shift via the MAPK/ERK signaling pathway in goat skeletal muscles J. Cell. Physiol. (IF 5.6) Pub Date : 2024-04-09 Zhen Zhang, Ziqi Kang, Kaiping Deng, Juan Li, Zhipeng Liu, Xinai Huang, Feng Wang, Yixuan Fan
Understanding how skeletal muscle fiber proportions are regulated is essential for understanding muscle function and improving the quality of mutton. While circular RNA (circRNA) has a critical function in myofiber type transformation, the specific mechanisms are not yet fully understood. Prior evidence indicates that circular ubiquitin‐specific peptidase 13 (circUSP13) can promote myoblast differentiation
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Retraction: “Downregulation of microRNA‐205 inhibits cell invasion and angiogenesis of cervical cancer through TSLC1‐mediated Akt signaling pathway” J. Cell. Physiol. (IF 5.6) Pub Date : 2024-04-09
Retraction: “Downregulation of microRNA‐205 inhibits cell invasion and angiogenesis of cervical cancer through TSLC1‐mediated Akt signaling pathway” by Fang Zhang, Jian Liu, Bei‐Bei Xie, J Cell Physiol 2019, 234: 18626–18638. The above article, published online on 2 May 2019 in Wiley Online Library (https://onlinelibrary.wiley.com/doi/10.1002/jcp.28501) has been retracted by agreement between the authors
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Retraction: “Evaluation of the neuroprotective effects of electromagnetic fields and coenzyme Q10 on hippocampal injury in mouse” J. Cell. Physiol. (IF 5.6) Pub Date : 2024-04-09
Retraction: “Evaluation of the neuroprotective effects of electromagnetic fields and coenzyme Q10 on hippocampal injury in mouse” by Mansoureh Soleimani, Fereshteh Golab, Akram Alizadeh, Sara Rigi, Zeinab Nazarian Samani, Gelareh Vahabzadeh, Tahmineh Peirovi, Maryam Sarbishegi, Majid Katebi, Fereshteh Azedi, J Cell Physiol 2019, 234: 18720–18730. The above article, published online on 1 April 2019
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Retraction: “Silencing lncRNA PVT1 inhibits activation of astrocytes and increases BDNF expression in hippocampus tissues of rats with epilepsy by downregulating the Wnt signaling pathway” J. Cell. Physiol. (IF 5.6) Pub Date : 2024-04-09
Retraction: “Silencing lncRNA PVT1 inhibits activation of astrocytes and increases BDNF expression in hippocampus tissues of rats with epilepsy by downregulating the Wnt signaling pathway”, by Teng Zhao, Ying Ding, Min Li, Chunkui Zhou, and Weihong Lin, J Cell Physiol. 2019; 234: 16054‐16067: The above article, published online on 25 February 2019 in Wiley Online Library (https://onlinelibrary.wiley
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Nodal negatively regulates osteoclast differentiation by inducing STAT1 phosphorylation J. Cell. Physiol. (IF 5.6) Pub Date : 2024-04-05 Jung Ha Kim, Kabsun Kim, Inyoung Kim, Semun Seong, Jeong‐Tae Koh, Nacksung Kim
Several members of the transforming growth factor beta (TGF‐β) superfamily regulate the proliferation, differentiation, and function of bone‐forming osteoblasts and bone‐resorbing osteoclasts. However, it is still unknown whether Nodal, a member of the TGF‐β superfamily, serves a function in bone cells. In this study, we found that Nodal did not have any function in osteoblasts but instead negatively
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Adipose tissue plasticity mediated by the counterregulatory axis of the renin‐angiotensin system: Role of Mas and MrgD receptors J. Cell. Physiol. (IF 5.6) Pub Date : 2024-04-05 Ana Beatriz Proença, Gabriela Rodrigues Medeiros, Guilherme dos Santos Reis, Luiza da França Losito, Luiza Mazzali Ferraz, Thereza Cristina Lonzetti Bargut, Nícia Pedreira Soares, Beatriz Alexandre‐Santos, Maria Jose Campagnole‐Santos, D'Angelo Carlo Magliano, Antonio Claudio Lucas da Nobrega, Robson Augusto Souza Santos, Eliete Dalla Corte Frantz
The renin‐angiotensin system (RAS) is an endocrine system composed of two main axes: the classical and the counterregulatory, very often displaying opposing effects. The classical axis, primarily mediated by angiotensin receptors type 1 (AT1R), is linked to obesity‐associated metabolic effects. On the other hand, the counterregulatory axis appears to exert antiobesity effects through the activation
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The immunological understanding on germinal center B cells in psoriasis J. Cell. Physiol. (IF 5.6) Pub Date : 2024-04-05 Aina Akmal Mohd Noor, Abdah Karimah Che Md Nor, Norhanani Mohd Redzwan
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Escargot a Snail superfamily member and its multiple roles in Drosophila melanogaster development J. Cell. Physiol. (IF 5.6) Pub Date : 2024-04-04 Diego Zambrano‐Tipan, Verónica Narváez‐Padilla, Enrique Reynaud
The Snail superfamily of transcription factors plays a crucial role in metazoan development; one of the most important vertebrate members of this family is Snai1 which is orthologous to the Drosophila melanogaster esg gene. This review offers a comprehensive examination of the roles of the esg gene in Drosophila development, covering its expression pattern and downstream targets, and draws parallels
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Retraction: “Long noncoding RNA ITGB2‐AS1 promotes growth and metastasis through miR‐4319/RAF1 axis in pancreatic ductal adenocarcinoma” J. Cell. Physiol. (IF 5.6) Pub Date : 2024-04-03
Retraction: “Long noncoding RNA ITGB2‐AS1 promotes growth and metastasis through miR‐4319/RAF1 axis in pancreatic ductal adenocarcinoma” by Ming Yang, Qi Qin, Junling Zhu, Yao Guo, Tao Yin, Heshui Wu, Chunyou Wang, J Cell Physiol 2020; 10.1002/jcp.29471. The above article, published online on 20 January 2020 in Wiley Online Library (https://onlinelibrary.wiley.com/doi/10.1002/jcp.29471) has been retracted
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Integrated analysis of transcriptome data revealed MMP3 and MMP13 as critical genes in anaplastic thyroid cancer progression J. Cell. Physiol. (IF 5.6) Pub Date : 2024-04-03
Yuehua Ma, Shundong Cang, Guoqing Li, Yong Su, Huifeng Zhang, Limin Wang, Junpeng Yang, Xiaoyang Shi, Guijun Qin, Huijuan Yuan In the original version of this article, the authors mistakenly used two panels from Figure 5b when assembling Figure 5c, leading to unintentional duplication. The correct Figure 5c is shown below. Figure 5C Open in figure viewerPowerPoint This correction doesn't change the
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Retraction: “Silencing of tumor‐suppressive NR_023387 in renal cell carcinoma via promoter hypermethylation and HNF4A deficiency” J. Cell. Physiol. (IF 5.6) Pub Date : 2024-04-03
Retraction: “Silencing of tumor‐suppressive NR_023387 in renal cell carcinoma via promoter hypermethylation and HNF4A deficiency” by Hui Zhou, Liang Guo, Weimin Yao, Runlin Shi, Gan Yu, Hua Xu, Zhangqun Ye, J Cell Physiol 2019, 235: 2113‐2128. The above article, published online on 20 August 2019 in Wiley Online Library (https://onlinelibrary.wiley.com/doi/full/10.1002/jcp.29115) has been retracted
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Metformin protects against vascular calcification through the selective degradation of Runx2 by the p62 autophagy receptor J. Cell. Physiol. (IF 5.6) Pub Date : 2024-04-03
Kanchan Phadwal, Eve Koo, Ross A. Jones, Rachael O. Forsythe, Keyi Tang, Qiyu Tang, Brendan M. Corcoran, Andrea Caporali, Vicky E. MacRae In the original version of this article, the authors mistakenly selected the wrong image for the LC3-I/LC3-II blot in Figure 4b, resulting in panel duplication. The correct Figure 4b is shown below. Figure 4 Open in figure viewerPowerPoint B. This correction doesn't
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FNDC5 inhibits malignant growth of human cervical cancer cells via restraining PI3K/AKT pathway J. Cell. Physiol. (IF 5.6) Pub Date : 2024-04-01 Na Li, Xiao‐Li Wang, Rui Ge, Yu Wang, Xiao‐Lei Tian, Guo‐Qing Zhu, Bing Zhou
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Retraction: “Reversible permeabilization of the mitochondrial membrane promotes human cardiomyocyte differentiation from embryonic stem cells” J. Cell. Physiol. (IF 5.6) Pub Date : 2024-03-27
Retraction: “Reversible permeabilization of the mitochondrial membrane promotes human cardiomyocyte differentiation from embryonic stem cells,” by Ghiasi P, Hosseinkhani S, Ansari H, Aghdami N, Balalaei S, Pahlavan S, Baharvand H. J Cell Physiol. 2019; 234: 521–536. https://doi.org/10.1002/jcp.26758The above article, published online on 2 August 2018, in Wiley Online Library (wileyonlinelibrary.com)
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Maternal Ezh1/2 deficiency impairs the function of mitochondria in mouse oocytes and early embryos J. Cell. Physiol. (IF 5.6) Pub Date : 2024-03-26 Dan Zhang, Wenbo Deng, Ting Jiang, Yinan Zhao, Dandan Bai, Yingpu Tian, Shuangbo Kong, Leilei Zhang, Haibin Wang, Shaorong Gao, Zhongxian Lu
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ZIP transporters‐regulated Zn2+ homeostasis: A novel determinant of human diseases J. Cell. Physiol. (IF 5.6) Pub Date : 2024-03-26 Huimei Liu, Lanfang Li, Ruirui Lu
As an essential trace element for organisms, zinc participates in various physiological processes, such as RNA transcription, DNA replication, cell proliferation, and cell differentiation. The destruction of zinc homeostasis is associated with various diseases. Zinc homeostasis is controlled by the cooperative action of zinc transporter proteins that are responsible for the influx and efflux of zinc
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ZNF263 cooperates with ZNF31 to promote the drug resistance and EMT of pancreatic cancer through transactivating RNF126 J. Cell. Physiol. (IF 5.6) Pub Date : 2024-03-22 Jiawei Zhang, Chuanping Chen, Qilong Geng, Haoyu Li, Mengcheng Wu, Boyuan Chan, Shiyang Wang, Weiwei Sheng
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Vasorin as an actor of bone turnover? J. Cell. Physiol. (IF 5.6) Pub Date : 2024-03-20 Caroline Andrique, Anne Laure Bonnet, Julien Dang, Julie Lesieur, A. Michaela Krautzberger, Brigitte Baroukh, Coralie Torrens, Jeremy Sadoine, Alain Schmitt, Gael Y. Rochefort, Claire Bardet, Isabelle Six, Pascal Houillier, Pierre Louis Tharaux, Heinrich Schrewe, Celine Gaucher, Catherine Chaussain
Bone diseases are increasing with aging populations and it is important to identify clues to develop innovative treatments. Vasn, which encodes vasorin (Vasn), a transmembrane protein involved in the pathophysiology of several organs, is expressed during the development in intramembranous and endochondral ossification zones. Here, we studied the impact of Vasn deletion on the osteoblast and osteoclast
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Restraining the power of Proteolysis Targeting Chimeras in the cage: A necessary and important refinement for therapeutic safety J. Cell. Physiol. (IF 5.6) Pub Date : 2024-03-19 Renshuai Zhang, Songbo Xie, Jie Ran, Te Li
Proteolysis Targeting Chimeras (PROTACs) represent a significant advancement in therapeutic drug development by leveraging the ubiquitin‐proteasome system to enable targeted protein degradation, particularly impacting oncology. This review delves into the various types of PROTACs, such as peptide‐based, nucleic acid‐based, and small molecule PROTACs, each addressing distinct challenges in protein degradation
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Hippocampal neurodegeneration induces transient endogenous regeneration and long‐term exhaustion of the neurogenic niche J. Cell. Physiol. (IF 5.6) Pub Date : 2024-03-19 Jhilik Dey, Sreyashi Chandra, Jalaj Gupta, Prem Prakash Tripathi
The hippocampal dentate gyrus, responds to diverse pathological stimuli through neurogenesis. This phenomenon, observed following brain injury or neurodegeneration, is postulated to contribute to neuronal repair and functional recovery, thereby presenting an avenue for endogenous neuronal restoration. This study investigated the extent of regenerative response in hippocampal neurogenesis by leveraging
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Naringin activates semaphorin 3A to ameliorate TGF‐β‐induced endothelial‐to‐mesenchymal transition related to atrial fibrillation J. Cell. Physiol. (IF 5.6) Pub Date : 2024-03-19 Ying‐Ju Lai, Shang‐Hung Chang, Ying‐Chang Tung, Gwo‐Jyh Chang, Celina De Almeida, Wei‐Jan Chen, Yung‐Hsin Yeh, Feng‐Chun Tsai
The loss of semaphorin 3A (Sema3A), which is related to endothelial‐to‐mesenchymal transition (EndMT) in atrial fibrosis, is implicated in the pathogenesis of atrial fibrillation (AF). To explore the mechanisms by which EndMT affects atrial fibrosis and assess the potential of a Sema3A activator (naringin) to prevent atrial fibrosis by targeting transforming growth factor‐beta (TGF‐β)‐induced EndMT
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Pathophysiological mechanisms of cardiomyopathies induced by desmin gene variants located in the C‐Terminus of segment 2B J. Cell. Physiol. (IF 5.6) Pub Date : 2024-03-19 Michelle Geryk, Flavien Charpentier
Desmin, the most abundant intermediate filament in cardiomyocytes, plays a key role in maintaining cardiomyocyte structure by interconnecting intracellular organelles, and facilitating cardiomyocyte interactions with the extracellular matrix and neighboring cardiomyocytes. As a consequence, mutations in the desmin gene (DES) can lead to desminopathies, a group of diseases characterized by variable
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Interaction between p21‐activated kinase 4 and β‐catenin as a novel pathway for PTH‐dependent osteoblast activation J. Cell. Physiol. (IF 5.6) Pub Date : 2024-03-18 Chen Shen, Ha Ram Oh, Young Ran Park, Jin Hong Chen, Byung‐Hyun Park, Ji Hyun Park
Parathyroid hormone (PTH) serves dual roles in bone metabolism, exhibiting both anabolic and catabolic effects. The anabolic properties of PTH have been utilized in the treatment of osteoporosis with proven efficacy in preventing fractures. Despite these benefits, PTH can be administered therapeutically for up to 2 years, and its use in patients with underlying malignancies remains a subject of ongoing
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HIF‐1α in cartilage homeostasis, apoptosis, and glycolysis in mice with steroid‐induced osteonecrosis of the femoral head J. Cell. Physiol. (IF 5.6) Pub Date : 2024-03-14 Yaling Yu, Yixin Jiang, Hongfan Ge, Xiaoli Fan, Hang Gao, Zhenlei Zhou
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LRRK2 regulates ferroptosis through the system Xc‐GSH–GPX4 pathway in the neuroinflammatory mechanism of Parkinson's disease J. Cell. Physiol. (IF 5.6) Pub Date : 2024-03-13 Zijian Zheng, Shushan Zhang, Xinjie Liu, Xiangrong Wang, Cheng Xue, Xiao Wu, Xinran Zhang, Xinping Xu, Zheng Liu, Longping Yao, Guohui Lu
Parkinson's disease (PD) is the most prevalent neurodegenerative disorder. Neuroinflammation mediated by activated microglia and apoptosis of dopaminergic (DA) neurons in the midbrain are its primary pathological manifestations. Leucine‐rich repeat protein kinase 2 (LRRK2) kinase has been observed to increase expression during neuroinflammation, however, the effect of LRRK2 on microglia activation
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GINS1 promotes ZEB1‐mediated epithelial‐mesenchymal transition and tumor metastasis via β‐catenin signaling in hepatocellular carcinoma J. Cell. Physiol. (IF 5.6) Pub Date : 2024-03-12 Junjie Liang, Nan Yao, Bo Deng, Jinying Li, Yuchuan Jiang, Tongzheng Liu, Youzhu Hu, Mingrong Cao, Jian Hong
GINS1 regulates DNA replication in the initiation and elongation phases and plays an important role in the progression of various malignant tumors. However, the role of GINS1 in hepatocellular carcinoma (HCC) remains largely unclear. In this study, we investigated the role and underlying mechanisms of GINS1 in contributing to HCC metastasis. We found that GINS1 was significantly upregulated in HCC
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Nrf2 pre‐recruitment at Enhancer 2 is a hallmark of H2O2‐induced epigenetic transcriptional memory in the HMOX1 gene in human umbilical artery endothelial cells J. Cell. Physiol. (IF 5.6) Pub Date : 2024-03-11 Ivo Carrasco‐Wong, Gernot Längst, Luis Sobrevia, Paola Casanello
Maternal obesity (MO) is a significant cause of increased cardiometabolic risk in offspring, who present endothelial dysfunction at birth. Alterations in physiologic and cellular redox status are strongly associated with altered gene regulation in arterial endothelium. However, specific mechanisms by which the pro‐oxidant fetal environment in MO could modulate the vascular gene expression and function
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Running a successful STEMM summer program: A week‐by‐week guide J. Cell. Physiol. (IF 5.6) Pub Date : 2024-03-11 Heather K. Beasley, Zer Vue, Melanie R. McReynolds, Edgar Garza‐Lopez, Kit Neikirk, Margaret Mungai, Andrea G. Marshall, Bryanna Shao, Jazmine I. Benjamin, Celestine N. Wanjalla, Clintoria R. Williams, Sandra A. Murray, Valerie K. Jordan, Haysetta D. Shuler, Annet Kirabo, Antentor Hinton
While some established undergraduate summer programs are effective across many institutions, these programs may only be available to some principal investigators or may not fully address the diverse needs of incoming undergraduates. This article outlines a 10‐week science, technology, engineering, mathematics, and medicine (STEMM) education program designed to prepare undergraduate students for graduate
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Recent advances in carbon quantum dots for gene delivery: A comprehensive review J. Cell. Physiol. (IF 5.6) Pub Date : 2024-03-08 Hazha Omar Othman, Esra Tariq Anwer, Diyar Salahuddin Ali, Rebwar Omar Hassan, Elnaz Ehsan Mahmood, Rayan Abubakir Ahmed, Rozhan Fathulla Muhammad, Slim Smaoui
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Reimagining bioRxiv and preprint servers as platforms for academic learning J. Cell. Physiol. (IF 5.6) Pub Date : 2024-03-08 Jazmine Benjamin, Celestine N. Wanjalla, Jennifer A. Gaddy, Annet Kirabo, Edith M. Williams, Antentor Hinton
A popular preprint server, bioRxiv, is important as a tool for increased visibility for life science research. If used properly, however, bioRxiv can also be an important tool for training, as it may expose trainees (degree‐seeking students undertaking research or internships directly related to their field of study) to the peer review process. Here, we offer a comprehensive guide to using bioRxiv
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Role of calcium integrin‐binding protein 1 in the mechanobiology of the liver endothelium J. Cell. Physiol. (IF 5.6) Pub Date : 2024-03-07 Cong Wang, Eric Felli, Sonia Selicean, Yeliduosi Nulan, Juan José Lozano, Sergi Guixé‐Muntet, Jaume Bosch, Annalisa Berzigotti, Jordi Gracia‐Sancho
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Interleukin‐35 protein inhibits osteoclastogenesis and attenuates collagen‐induced arthritis in mice J. Cell. Physiol. (IF 5.6) Pub Date : 2024-03-07 Lin Yuan, Yuxuan Li, Dan Liu, Hui Zhang, Jie Yang, Hui Shen, Liping Xia, Lutian Yao, Jing Lu
Rheumatoid arthritis (RA) is a chronic autoimmune disease. Its pathological features include synovial inflammation, bone erosion, and joint structural damage. Our previous studies have shown that interleukin (IL)‐35 is involved in the pathogenesis of bone loss in RA patients. In this study, we are further evaluating the efficacy of IL‐35 on collagen‐induced arthritis (CIA) in the mouse model. Male
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Multifaceted roles of PDCD6 both within and outside the cell J. Cell. Physiol. (IF 5.6) Pub Date : 2024-03-04 Yigao Zhu, Qingchao Li
Programmed cell death protein 6 (PDCD6) is an evolutionarily conserved Ca2+‐binding protein. PDCD6 is involved in regulating multifaceted and pleiotropic cellular processes in different cellular compartments. For instance, nuclear PDCD6 regulates apoptosis and alternative splicing. PDCD6 is required for coat protein complex II‐dependent endoplasmic reticulum‐to‐Golgi apparatus vesicular transport in
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Retraction: “Mesoglycan exerts its fibrinolytic effect through the activation of annexin A2” J. Cell. Physiol. (IF 5.6) Pub Date : 2024-03-01
Retraction: “Mesoglycan exerts its fibrinolytic effect through the activation of annexin A2” by Raffaella Belvedere, Elva Morretta, Emanuela Pessolano, Nunzia Novizio, Alessandra Tosco, Amalia Porta, James Whiteford, Mauro Perretti, Amelia Filippelli, Maria Chiara Monti, Antonello Petrella, J Cell Physiol. 2020, 236: 4926–4943. The above article, published online on 7 December 2020 in Wiley Online
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Human antigen R: Exploring its inflammatory response impact and significance in cardiometabolic disorders J. Cell. Physiol. (IF 5.6) Pub Date : 2024-03-01 Shahenda Salah Abdelsam, Sarah Khalaf Ghanem, Muhammad Ammar Zahid, Hanan H. Abunada, Loulia Bader, Hicham Raïq, Abbas Khan, Aijaz Parray, Laiche Djouhri, Abdelali Agouni
RNA‐binding proteins (RBPs) play a crucial role in the regulation of posttranscriptional RNA networks, which can undergo dysregulation in many pathological conditions. Human antigen R (HuR) is a highly researched RBP that plays a crucial role as a posttranscriptional regulator. HuR plays a crucial role in the amplification of inflammatory signals by stabilizing the messenger RNA of diverse inflammatory
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ATF4-dependent increase in mitochondrial-endoplasmic reticulum tethering following OPA1 deletion in skeletal muscle J. Cell. Physiol. (IF 5.6) Pub Date : 2024-02-28 Antentor Hinton, Prasanna Katti, Margaret Mungai, Duane D. Hall, Olha Koval, Jianqiang Shao, Zer Vue, Edgar Garza Lopez, Rahmati Rostami, Kit Neikirk, Jessica Ponce, Jennifer Streeter, Brandon Schickling, Serif Bacevac, Chad Grueter, Andrea Marshall, Heather K. Beasley, Young Do Koo, Sue C. Bodine, Nayeli G. Reyes Nava, Anita M. Quintana, Long-Sheng Song, Isabella M. Grumbach, Renata O. Pereira, Brian
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AMP‐activated protein kinase as a mediator of mitochondrial dysfunction of multiple sclerosis in animal models: A systematic review J. Cell. Physiol. (IF 5.6) Pub Date : 2024-02-26 Hamid Askari, Fatemeh Rabiei, Fatemeh Lohrasbi, Sara Ghadir, Ahmad Mehdipour Arbastan, Maryam Ghasemi‐Kasman
Multiple sclerosis (MS) is a chronic central nervous system (CNS) disorder characterized by demyelination, neuronal damage, and oligodendrocyte depletion. Reliable biomarkers are essential for early diagnosis and disease management. Emerging research highlights the role of mitochondrial dysfunction and oxidative stress in CNS disorders, including MS, in which mitochondria are central to the degenerative
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Non‐coding RNA LINC01010 regulates macrophage polarization and innate immune functions by modulating NFκB signaling pathway J. Cell. Physiol. (IF 5.6) Pub Date : 2024-02-26 Araceli Valverde, Raza Ali Naqvi, Afsar R. Naqvi
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Epigenetic reprogramming in the transition from pluripotency to totipotency J. Cell. Physiol. (IF 5.6) Pub Date : 2024-02-20 Qingsheng Han, Ru Ma, Na Liu
Mammalian development commences with the zygote, which can differentiate into both embryonic and extraembryonic tissues, a capability known as totipotency. Only the zygote and embryos around zygotic genome activation (ZGA) (two‐cell embryo stage in mice and eight‐cell embryo in humans) are totipotent cells. Epigenetic modifications undergo extremely extensive changes during the acquisition of totipotency
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m6A‐induced TRIB3 regulates Hippo pathway through interacting with LATS1 to promote the progression of lung adenocarcinoma J. Cell. Physiol. (IF 5.6) Pub Date : 2024-02-19 Jiamei Wu, Tingzhuang Yi, Chenyi Zhuo, Duanduan Wang, Ming Zhang, Rui Hu, Dan Wu, Guoxin Hou, Yutong Xing
Recent studies have indicated that dysregulation of the Hippo/Yes‐associated protein (YAP) axis is associated with tumor progression and therapy resistance in various cancer types, including lung adenocarcinoma (LUAD). Understanding the regulation of Hippo signaling in LUAD is of great significance. Elevated levels of TRIB3, a pseudo kinase, have been observed in certain lung malignancies and are associated
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MAGP2 promotes osteogenic differentiation during fracture healing through its crosstalk with the β-catenin pathway J. Cell. Physiol. (IF 5.6) Pub Date : 2024-02-13 Zhiguang Chen, Qi Zhao, Lianghong Chen, Songlan Gao, Lingshuai Meng, Yingjie Liu, Yu Wang, Tiegang Li, Jinqi Xue
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Identification of binding partners that facilitate membrane-type 5 matrix metalloproteinase (MT5-MMP) processing of amyloid precursor protein J. Cell. Physiol. (IF 5.6) Pub Date : 2024-02-12 Hongjie Wang, Madepalli K. Lakshmana, Gregg B. Fields
One of the pathological hallmarks of Alzheimer's disease (AD) is the presence of extracellular deposits of amyloid beta (Aβ) peptide. In addition to Aβ as the core component of the amyloid plaque, the amyloid precursor protein (APP) processing fragment Aβ was also found accumulated around the plaque. The APPη pathway, mainly mediated by membrane-type 5 matrix metalloproteinase (MT5-MMP), represents
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Abnormal stress promotes intervertebral disc degeneration through WTAP/YTHDF2-dependent TIMP3 m6A modification J. Cell. Physiol. (IF 5.6) Pub Date : 2024-02-12 Daokuan Gao, Quanlai Zhao, Chen Liu, Yu Zhang, Liang Xiao
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RING finger E3 ligase, RNF138 inhibits osteoblast differentiation by negatively regulating Runx2 protein turnover J. Cell. Physiol. (IF 5.6) Pub Date : 2024-02-07 Vishal Upadhyay, Anil Kumar Singh, Shivani Sharma, Arppita Sethi, Swati Srivastava, Sangita Chowdhury, Shumaila Siddiqui, Naibedya Chattopadhyay, Arun Kumar Trivedi
A few ubiquitin ligases have been shown to target Runx2, the key osteogenic transcription factor and thereby regulate bone formation. The regulation of Runx2 expression and function are controlled both at the transcriptional and posttranslational levels. Really interesting new gene (RING) finger ubiquitin ligases of which RNF138 is a member are important players in the ubiquitin-proteasome system,
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Role of c-Fos in DNA damage repair J. Cell. Physiol. (IF 5.6) Pub Date : 2024-02-07 Haiyang Yao, Yilun Wu, Yiming Zhong, Chenxuan Huang, Zimo Guo, Yinpeng Jin, Xianli Wang
c-Fos, a member of the immediate early gene, serves as a widely used marker of neuronal activation induced by various types of brain damage. In addition, c-Fos is believed to play a regulatory role in DNA damage repair. This paper reviews the literature on c-Fos' involvement in the regulation of DNA damage repair and indicates that genes of the Fos family can be induced by various forms of DNA damage