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Cefepime distribution by microdialysis in peritoneal fluid of rats with or without experimental peritonitis APMIS (IF 2.8) Pub Date : 2024-04-25 Michele Vaz dos Anjos, Eduarda Possa, Gisele da Silva Fonseca, Larissa Bergoza, Leandro Tasso
The aim of this study was to investigate the penetration of cefepime into rat peritoneal fluid by microdialysis and to determine the relationship between unbound drug plasma and tissue concentration in healthy animals and in a sepsis model established through cecal ligation and puncture‐induced peritonitis. Probe recovery was performed by dialysis and retrodialysis. Cefepime was administered at a dose
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LncRNA SNHG1 serves as a biomarker for systemic lupus erythematosus and participates in the disease progression APMIS (IF 2.8) Pub Date : 2024-04-21 Linsen Jiang, Anning Qi, Hongyu Yang, Shuping Wang, Fei Wang, Xuemei Bai, Juan Ren
LncRNAs play an important role in autoimmune diseases. The purpose of this study was to explore the role of lncRNA SNHG1 in systemic lupus erythematosus (SLE), and laid a theoretical foundation for the study of SLE. The basic clinical information of all subjects was first collected for statistical analysis, and SNHG1 expression in the serum of all subjects was detected by RT-qPCR. The value of SNHG1
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Short communication: abdominal infective native aortic aneurysm due to an unusual gram‐negative rod: beware of the dog! APMIS (IF 2.8) Pub Date : 2024-04-16 Claire Duployez, Louise Bronner, Emilie Dubois, Joanna Haustrate, Sarah Stabler, Caroline Loïez, Frédéric Wallet
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IGSF3 tissue expression in squamous cell carcinoma of the oropharynx: a novel tool for prognosis assessment in HPV‐related and HPV‐unrelated disease APMIS (IF 2.8) Pub Date : 2024-04-16 Anni Sjöblom, Lauri Jouhi, Pirjo Laakkonen, Reija Randén‐Brady, Jussi Tarkkanen, Caj Haglund, Petri Mattila, Timo Carpén, Jaana Hagström, Antti Mäkitie
Biomarkers are not broadly used in the management of head and neck cancers (HNCs). Biomarkers have been beneficial in the management of other cancers, however, not in HNCs. Therefore, we observed the immunopositivity of a novel biomarker called immunoglobulin superfamily member 3 (IGSF3) in tumor tissues in HPV‐related and HPV‐unrelated OPSCC. Two patient cohorts (C1 and C2) from separate time periods
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Increased susceptibility to azithromycin of Pseudomonas aeruginosa biofilms using RPMI 1640 testing media APMIS (IF 2.8) Pub Date : 2024-04-16 Adrian Jimenez San San Mauro, Niels Høiby, Oana Ciofu
Azithromycin (AZM) is efficient for treatment of chronic Pseudomonas aeruginosa biofilm lung infections, despite of resistance in conventional susceptibility testing. It has been shown that planktonic P. aeruginosa are more susceptible to AZM when tested in RPMI 1640 medium. The aim of the study was to test the susceptibility to AZM of P. aeruginosa biofilms in LB vs RPMI 1640 media. We investigated
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The role of hsa_circ_0042260/miR‐4782‐3p/LAPTM4A axis in gestational diabetes mellitus APMIS (IF 2.8) Pub Date : 2024-04-08 Rui Ji, Hong Yang, Jiamei Chen, Anna Zhao, Xia Chen, Yanli Niu
Gestational diabetes mellitus (GDM) is a common metabolic condition during pregnancy, posing risks to both mother and fetus. CircRNAs have emerged as important players in various diseases, including GDM. We aimed to investigate the role of newly discovered circRNA, hsa_circ_0042260, in GDM pathogenesis. Using GSE194119 dataset, hsa_circ_0042260 was identified and its expression in plasma, placenta
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Pathophysiological microenvironments in oral candidiasis APMIS (IF 2.8) Pub Date : 2024-04-04 Mette Rose Jørgensen
Oral candidiasis (OC), a prevalent opportunistic infection of the oral mucosa, presents a considerable health challenge, particularly in individuals with compromised immune responses, advanced age, and local predisposing conditions. A considerable part of the population carries Candida in the oral cavity, but only few develop OC. Therefore, the pathogenesis of OC may depend on factors other than the
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ST2 and IL‐33 polymorphisms and the development of childhood asthma: a prospective birth cohort study in Finnish children APMIS (IF 2.8) Pub Date : 2024-04-03 Johanna T. Teräsjärvi, Laura Toivonen, Jussi Mertsola, Ville Peltola, Qiushui He
The ST2/IL‐33 signaling pathway has an important role in the host inflammatory response. Here we aimed to study the association of ST2 and IL‐33 polymorphisms with serum soluble (s) ST2 and IL‐33 concentrations in healthy Finnish children and, in addition, their association with childhood asthma. In total, 146 children were followed from birth to the age 7 years for the development of asthma. Single‐nucleotide
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The microenvironment in antibiotic susceptibility testing APMIS (IF 2.8) Pub Date : 2024-04-03 Niels Høiby, Claus Moser, Oana Ciofu
Antibiotic susceptibility testing (AST) by agar diffusion has been repeatedly standardized and, in most cases, gives results which predict clinical success when antibiotic treatment is based on such results. The formation of the inhibition zone is due to a transition from planktonic to biofilm mode of growth. The kinetics of the interaction of antibiotics with bacteria is similar during AST by agar
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Exploring the immune‐modulating properties of boswellic acid in experimental autoimmune encephalomyelitis APMIS (IF 2.8) Pub Date : 2024-04-02 Alireza Shadab, Mohammad Abbasi‐Kolli, Esmaeil Yazdanpanah, Seyed‐Alireza Esmaeili, Rasoul Baharlou, Bahman Yousefi, Dariush Haghmorad
Multiple sclerosis (MS) is a condition where the central nervous system loses its myelin coating due to autoimmune inflammation. The experimental autoimmune encephalomyelitis (EAE) simulates some aspects of human MS. Boswellic acids are natural compounds derived from frankincense extract, known for their anti‐inflammatory properties. The purpose of this research was to investigate therapeutic potential
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Pharmacokinetic and pharmacodynamic evaluation of nitrofurantoin against Escherichia coli in a murine urinary tract infection model APMIS (IF 2.8) Pub Date : 2024-04-01 Marit Gaastra Maaland, Lotte Jakobsen, Luca Guardabassi, Niels Frimodt‐Møller
The antimicrobial agent nitrofurantoin is becoming increasingly important for treatment of urinary tract infections (UTIs) due to widespread occurrence of multidrug‐resistant Escherichia coli. Despite many years of use, little data on nitrofurantoin pharmacokinetics (PK) or ‐dynamics (PD) exist. The objective of this study was to (i) evaluate the pharmacokinetics of nitrofurantoin in a mouse model
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Rapid identification of SARS-CoV-2 variants using stable high-frequency mutation sites APMIS (IF 2.8) Pub Date : 2024-03-15 Yu Fu, Xiaobai He, Quan Fang, Fei Kong, Yan Zhang, Ting Fu, Liang Chen, YanXin Liu, Zhen Wang, Jianxin Lyu, Linjie Chen
Respiratory infectious viruses, including SARS-CoV-2, undergo rapid genetic evolution, resulting in diverse subtypes with complex mutations. Detecting and differentiating these subtypes pose significant challenges in respiratory virus surveillance. To address these challenges, we integrated ARMS-PCR with molecular beacon probes, allowing selective amplification and discrimination of subtypes based
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Multiplex PCR for respiratory bacteria in acute care APMIS (IF 2.8) Pub Date : 2024-03-14 Elina Saarela, Marjo Renko, Matti Uhari, Tytti Pokka, Heikki Kauma, Terhi S. Ruuska
The purpose of the study was to evaluate the clinical utility of multiplex PCR for detecting bacterial respiratory pathogens in nasopharyngeal samples. Acutely ill adults in the emergency department with respiratory infection symptoms, fever, chest pain or poor general condition were enrolled for this cohort study. Samples were stored at –70 °C until being analysed with multiplex PCR for seven respiratory
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Exploring the significance of microbiota metabolites in rheumatoid arthritis: uncovering their contribution from disease development to biomarker potential APMIS (IF 2.8) Pub Date : 2024-03-12 Zi‐feng Lu, Chou‐Yi Hsu, Nada Khairi Younis, Mohammed Ahmed Mustafa, Elena A. Matveeva, Yassien Hussain Owaied Al‐Juboory, Mohaned Adil, Zainab H. Athab, Mustafa Nasrat Abdulraheem
Rheumatoid arthritis (RA) is a multifaceted autoimmune disorder characterized by chronic inflammation and joint destruction. Recent research has elucidated the intricate interplay between gut microbiota and RA pathogenesis, underscoring the role of microbiota‐derived metabolites as pivotal contributors to disease development and progression. The human gut microbiota, comprising a vast array of microorganisms
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The autonomic nerves around the vein of Marshall: a postmortem study with clinical implications APMIS (IF 2.8) Pub Date : 2024-03-12 Denis Depes, Ari Mennander, Paavo Immonen, Artturi Mäkinen, Heini Huhtala, Timo Paavonen, Ivana Kholová
This study aims to analyze the vein of Marshall (VOM) in human autopsy hearts and its correlation with clinical data to elucidate the morphological substrates of atrial fibrillation (AF) and other cardiac diseases. Twenty‐three adult autopsy hearts were studied, assessing autonomic nerves by immunohistochemistry with tyrosine hydroxylase (sympathetic nerves), choline acetyltransferase (parasympathetic
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Antifungal drug resistance in Candida: a special emphasis on amphotericin B APMIS (IF 2.8) Pub Date : 2024-03-11 Lailema Ahmady, Manisha Gothwal, Muhammed Mushthaque Mukkoli, Vinay Kumar Bari
Invasive fungal infections in humans caused by several Candida species, increased considerably in immunocompromised or critically ill patients, resulting in substantial morbidity and mortality. Candida albicans is the most prevalent species, although the frequency of these organisms varies greatly according to geographic region. Infections with C. albicans and non-albicans Candida species have become
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Surgery of enlarging lesions after stereotactic radiosurgery for brain metastases in patients with non‐small cell lung cancer with oncogenic driver mutations frequently reveals radiation necrosis: case series and review APMIS (IF 2.8) Pub Date : 2024-03-11 Fang Zhou, Leilei Jiang, Xuankai Sun, Zhen Wang, Jialin Feng, Ming Liu, Zhao Ma
In brain metastases, radiation necrosis (RN) is a complication that arises after single or multiple fractionated stereotactic radiosurgery (SRS/FSRS), which is challenging to distinguish from local recurrence (LR). Studies have shown increased RN incidence rates in non‐small cell lung cancer (NSCLC) patients with oncogenic driver mutations (ODMs) or receiving tyrosine kinase inhibitors (TKIs). This
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Understanding the biofilm development of Acinetobacter baumannii and novel strategies to combat infection APMIS (IF 2.8) Pub Date : 2024-03-05 Naji Naseef Pathoor, Akshaya Viswanathan, Gulshan Wadhwa, Pitchaipillai Sankar Ganesh
Acinetobacter baumannii (A. baumannii) is a Gram-negative, nonmotile, and aerobic bacillus emerged as a superbug, due to increasing the possibility of infection and accelerating rates of antimicrobial agents. It is recognized as a nosocomial pathogen due to its ability to form biofilms. These biofilms serve as a defensive barrier, increase antibiotic resistance, and make treatment more difficult. As
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Pathological image profiling identifies onco‐microbial, tumor immune microenvironment, and prognostic subtypes of colorectal cancer APMIS (IF 2.8) Pub Date : 2024-02-26 Yuwen Chu, Shuo Zhang, Wei Wan, Jialiang Yang, Yumeng Zhang, Chuanqi Nie, Weipeng Xing, Shanhe Tong, Jinyang Liu, Geng Tian, Bing Wang, Lei Ji
Histology slide, tissue microbes, and the host gene expression can be independent prognostic factors of colorectal cancer (CRC), but the underlying associations and biological significance of these multimodal omics remain unknown. Here, we comprehensively profiled the matched pathological images, intratumoral microbes, and host gene expression characteristics in 527 patients with CRC. By clustering
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Informed development of a multi-species biofilm in chronic obstructive pulmonary disease APMIS (IF 2.8) Pub Date : 2024-02-21 Bryn Short, Christopher Delaney, William Johnston, Gary J. Litherland, John C. Lockhart, Craig Williams, William G. Mackay, Gordon Ramage
Recent evidence indicates that microbial biofilm aggregates inhabit the lungs of COPD patients and actively contribute towards chronic colonization and repeat infections. However, there are no contextually relevant complex biofilm models for COPD research. In this study, a meta-analysis of the lung microbiome in COPD was used to inform development of an optimized biofilm model composed of genera highly
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Humoral immune response of Galleria mellonella after mono- and co-injection with Hypericum perforatum extract and Candida albicans APMIS (IF 2.8) Pub Date : 2024-02-12 Tülay Turgut Genç, Serhat Kaya, Melih Günay, Çağla Çakaloğlu
Galleria mellonella is used as a model organism to study the innate immune response of insects. In this study, the humoral immune response was assessed by examining phenoloxidase activity, fungal burden, and the expression of phenoloxidase and antimicrobial peptide genes at different time point following separate and combined injections of Hypericum perforatum extract and a nonlethal dose of Candida
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Inflammatory mediators in bacterial vaginosis: The role of cytokines APMIS (IF 2.8) Pub Date : 2024-02-12 Yuexin Zhang, Zhi He
BV is a significant concern in women's health with a varying prevalence rate in different cities of China. The condition has been linked to the acquisition of STIs, including HIV and HPV, and can lead to infertility, adverse obstetric outcomes. We conducted a comprehensive literature search in the PubMed. The search was performed from 01/01/2018 to 01/09/2023. The following search terms were used:
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Bacterial aerobic respiration is a major consumer of oxygen in sputum from patients with acute lower respiratory tract infection APMIS (IF 2.8) Pub Date : 2024-01-29 Peter Østrup Jensen, Pernille Olsen, Arnold Matovu Dungu, Gertrud Baunbæk Egelund, Andreas Vestergaard Jensen, Pernille Ravn, Birgitte Lindegaard, Frederik Boëtius Hertz, Thomas Bjarnsholt, Daniel Faurholt-Jepsen, Mette Kolpen
Bacterial aerobic respiration may determine the outcome of antibiotic treatment in experimental settings, but the clinical relevance of bacterial aerobic respiration for the outcome of antibiotic treatment has not been tested. Therefore, we hypothesized that bacterial aerobic respiration is higher in sputum from patients with acute lower respiratory tract infections (aLRTI), than in sputum from patients
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Virology and safety profile of Molnupiravir at three different doses for treatment of SARS-CoV-2: a systematic review and meta-analysis APMIS (IF 2.8) Pub Date : 2024-01-30 Mahnoor Sukaina, Syed Hasan Shuja, Syeda Tayyaba Rehan, Sidhant Ochani, Muhammad Sheryar
Molnupiravir is incorporated into the viral genome, thereby increasing errors, mismatching, and misdirecting the viral polymerase thereby, halting viral RNA replication of SARS-CoV-2. Following PRISMA guidelines, a thorough literature search was performed on electronic and medical databases from December 2022 till January 2023. Molnupiravir 800 mg showed significance in creating viral RNA error rate
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Clinical implications of AGR2 in primary prostate cancer: Results from a large-scale study APMIS (IF 2.8) Pub Date : 2024-01-30 Moritz Wambach, Matteo Montani, Josefine Runz, Carsten Stephan, Klaus Jung, Holger Moch, Daniel Eberli, Marit Bernhardt, Oliver Hommerding, Tobias Kreft, Marcus V. Cronauer, Anika Kremer, Thomas Mayr, Stefan Hauser, Glen Kristiansen
Human anterior gradient-2 (AGR2) has been implicated in carcinogenesis of various solid tumours, but the expression data in prostate cancer are contradictory regarding its prognostic value. The objective of this study is to evaluate the expression of AGR2 in a large prostate cancer cohort and to correlate it with clinicopathological data. AGR2 protein expression was analysed immunohistochemically in
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Immune responses to mRNA-based vaccines given as a third COVID-19 vaccine dose in people living with HIV—a literature review APMIS (IF 2.8) Pub Date : 2024-01-26 Maria Lodberg Knudsen, Susanne Dam Nielsen, Line Dam Heftdal
People living with HIV (PLWH) were not included in the first efficacy studies of mRNA vaccines against SARS-CoV-2. In this literature review, we investigate evidence of humoral and cellular immunity after a third dose of an mRNA vaccine in PLWH. We performed a literature search in PubMed, Embase, Web of Science and SCOPUS published between 1 January 2020 and 31 December 2022. Selection criteria were
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Novel sampling technique maintaining the two-dimensional organization of microbes during cultivation from chronic wounds: The Imprint method APMIS (IF 2.8) Pub Date : 2024-01-25 Anne Kristine Servais Iversen, Blaine Gabriel Fritz, Mads Joachim Hansen, Klaus Kirketerp-Møller, Tim Holm Jakobsen, Thomas Bjarnsholt, Mads Lichtenberg
This study aimed to develop and validate “the Imprint method,”, a technique for sampling microbes from chronic wounds while preserving their two-dimensional spatial organization. We used nylon filters to sample bacteria and compared with sampling using Eswabs in 12 patients. The Imprint method identified a mean of 0.93 unique species more than Eswab (4.3 ± 2.2 and 3.4 ± 1.4 unique species, respectively;
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Close monitoring and early intervention: management principles for cystic fibrosis in Denmark APMIS (IF 2.8) Pub Date : 2024-01-24 Tavs Qvist, Bibi Uhre Nielsen, Hanne Vebert Olesen, Inger Hee Mabuza Mathiesen, Daniel Faurholt-Jepsen, Terese L. Katzenstein, Jannik Helweg-Larsen, Frederikke Rönsholt, Majbritt Jeppesen, Mette Frahm Olsen, Frederik Fouirnaies Buchvald, Kim Gjerum Nielsen, Søren Jensen-Fangel, Tania Pressler, Marianne Skov
Cystic fibrosis (CF) care in Denmark has been characterized by close monitoring and pre-emptive treatment of lung disease and other CF-related complications. Continuous evaluation through data collection and commitment to clinical research has incrementally improved outcomes. This approach has been in line with best practices set forth by European Standards of Care but has also gone beyond Society
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Metabolic drives affecting Th17/Treg gene expression changes and differentiation: impact on immune-microenvironment regulation APMIS (IF 2.8) Pub Date : 2024-01-18 Carolina Brescia, Salvatore Audia, Alessia Pugliano, Federica Scaglione, Rodolfo Iuliano, Francesco Trapasso, Nicola Perrotti, Emanuela Chiarella, Rosario Amato
The CD4+ T-cell population plays a vital role in the adaptive immune system by coordinating the immune response against different pathogens. A significant transformation occurs in CD4+ cells during an immune response, as they shift from a dormant state to an active state. This transformation leads to extensive proliferation, differentiation, and cytokine production, which contribute to regulating and
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Functional studies with IgM and IgA immunoglobulins: binding to pIgR, FcαμR, FcμR, and CDC activities APMIS (IF 2.8) Pub Date : 2024-01-17 Hanna Beyer, Mark Sommerfeld, Kaj Grandien, Christine Faust, Bodo Tillmann, Wulf Dirk Leuschner, Anne Régnier-Vigouroux, Sandra Weil, Ercole Rao, Thomas Langer
IgMs are the first antibodies produced by the immune system upon encounter of a possible pathogen and are one of five antibody subclasses in humans. For IgG, the most intensively studied antibody class, the N-linked glycosylation site located in the Fc-domain is directly involved in high affinity binding to the respective receptors and initiation of corresponding immune response. IgM molecules have
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FilmArray (BCID2) provides essential and timely results in bloodstream infections in small acute care hospitals without conventional microbiology services APMIS (IF 2.8) Pub Date : 2024-01-12 Hege Harboe-Sjåvik, Kristoffer Hammer Endresen, Sandra Åsheim, Arnfinn Sundsfjord
We have evaluated the performance of FilmArray BCID2 in reactive blood cultures in a small acute care hospital compared to conventional diagnostics at a regional microbiological laboratory. This is a retrospective observational study of BactAlert reactive blood cultures (n = 160) from Helgeland Hospital, July–December 2021, analysed by BCID2 locally and conventional culture at a regional laboratory
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Inhibiting pathogenicity of vaginal Candida albicans by lactic acid bacteria and MS analysis of their extracellular compounds APMIS (IF 2.8) Pub Date : 2024-01-02 Shreaya Das, Bolin Kumar Konwar
Maintaining healthy vaginal microflora post-puberty is critical. In this study we explore the potential of vaginal lactic acid bacteria (LAB) and their extracellular metabolites against the pathogenicity of Candida albicans. The probiotic culture free supernatant (PCFS) from Lactobacillus crispatus, L. gasseri, and L. vaginalis exhibit an inhibitory effect on budding, hyphae, and biofilm formation
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Rifampicin does not reduce moxifloxacin concentrations at the site of infection and may not improve treatment outcome of a one-stage exchange surgery protocol of implant-associated osteomyelitis lesions in a porcine model APMIS (IF 2.8) Pub Date : 2023-12-28 Sofus Vittrup, Louise Kruse Jensen, Katrine Top Hartmann, Bent Aalbæk, Pelle Hanberg, Josefine Slater, Magnus Andreas Hvistendahl, Maiken Stilling, Nis Pedersen Jørgensen, Mats Bue
We aimed to evaluate moxifloxacin steady-state concentrations in infected bone and soft tissue and to explore the additive microbiological and pathological treatment effect of rifampicin to standard moxifloxacin treatment of implant-associated osteomyelitis (IAO). 16 pigs were included. On Day 0, IAO was induced in the proximal tibia using a susceptible Staphylococcus aureus strain. On Day 7, the pigs
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Impact of RYGB surgery on plasma immunoglobulins: association between blood pressure and glucose levels six months after surgery APMIS (IF 2.8) Pub Date : 2023-12-27 Natalie Happonen, Mari-Anne Härma, Ramin Akhi, Antti E. Nissinen, Markku J. Savolainen, Maija Ruuth, Katariina Öörni, Krishna Adeshara, Markku Lehto, Per-Henrik Groop, Vesa Koivukangas, Janne Hukkanen, Sohvi Hörkkö
We aimed to study levels of natural antibodies in plasma, and their associations to clinical and fecal biomarkers, before and 6 months after Roux-en-Y gastric bypass (RYGB) surgery. Thirty individuals with obesity [16 type 2 diabetic, 14 non-diabetic (ND)] had RYGB surgery. Total plasma IgA, IgG and IgM antibody levels and specific antibodies to oxidized low-density lipoprotein (oxLDL), malondialdehyde-acetaldehyde
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Retraction: ‘Curcumin inhibits the survival and metastasis of prostate cancer cells via the Notch-1 signaling pathway’, by Jingzhe Yang, Chengli Wang, Zhijie Zhang, Xiaojun Chen, Yusen Jia, Bin Wang, Tao Kong, APMIS. 2017; 125: 134–140: The above article, published online on 24 January 2017 in Wiley Online Library (https://onlinelibrary.wiley.com/doi/10.1111/apm.12650) has been retracted by agreement APMIS (IF 2.8) Pub Date : 2023-12-26
The retraction has been agreed due to unattributed overlap between this article and the following article: ‘Curcumin inhibits cell survival and migration by suppression of Notch-1 activity in prostate cancer cells’ by Tao Kong, Yongxing Wang, Li Xiao and Limin Liao; African Journal of Pharmacy and Pharmacology, Vol.7(27), pp. 1911-1916, 2013, https://doi.org/10.5897/AJPP2012.1526. The authors were
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Evaluation of transcription factors and cytokine expressions of T-cell subsets in CD19 deficiency and their possible relationship with autoimmune disease APMIS (IF 2.8) Pub Date : 2023-12-14 Serkan Küççüktürk, Mehmet Ali Karaselek, Tuğçe Duran, İsmail Reisli
CD19 deficiency is a rare, predominantly antibody deficiency, and there are few studies showing that it can be seen in autoimmune diseases. The aim of study was evaluated to transcription factor and cytokine expressions of helper T (Th)-cell subsets in CD19 deficiency and the possible mechanism role of this factor expression in autoimmune disease. Transcription factor and cytokine expressions of Th1
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Short communication: first case of bacteraemia caused by Dielma fastidiosa in a patient hospitalized with diverticulitis APMIS (IF 2.8) Pub Date : 2023-12-14 Barbara Forman-Ankjær, Frederik Hvid-Jensen, Carl Mathias Kobel, Thomas Greve
Dielma fastidiosa is a gram-negative, anaerobic rod belonging to the family Erysipelotrichaceae. D. fastidiosa has previously been isolated in human stool samples as part of the commensal flora; however, prior to this case, it has never been identified as a human pathogen. We present the first case of bacteraemia with D. fastidiosa. Bacterial growth in the blood culture bottle was detected by the automated
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Anemia in liver transplant recipients: prevalence, severity, risk factors, and survival APMIS (IF 2.8) Pub Date : 2023-12-11 Nina Øksnes Hegland, Omid Rezahosseini, Christian Ross Pedersen, Dina Leth Møller, Terese Brun Bugge, Neval Ete Wareham, Nicoline Stender Arentoft, Jens Hillingsø, Thomas Kromann Lund, Allan Rasmussen, Susanne Dam Nielsen
Information about anemia in liver transplant (LTx) recipients is scarce. We investigated the prevalence and severity of anemia before and within the first-year post-LTx, risk factors for having anemia before LTx, and 1-year survival according to anemia status before LTx. This retrospective cohort study received data from The Knowledge Center for Transplantation database at Rigshospitalet, Copenhagen
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Bacteriophage-based approach for treatment of urinary tract infections: a quick outlook APMIS (IF 2.8) Pub Date : 2023-11-29 Bartłomiej Grygorcewicz, Marta Gliźniewicz, Joanna Jabłońska, Adrian Augustyniak, Patrycja Olszewska, Bartosz Wojciuk, Dominika Miłek, Natalia Serwin, Artur Czajkowski, Elżbieta Cecerska-Heryć, Rafał Rakoczy, Aneta Cymbaluk-Płoska
Urinary tract infections (UTIs) are among the most common bacterial infections affecting millions worldwide. The increasing emergence of antibiotic-resistant bacteria has become a serious concern in managing UTIs. Therefore, there is a growing interest in using bacteriophages as an alternative or adjunct therapy for UTIs. Bacteriophages are viruses that infect and kill bacteria, making them a promising
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The microbiome in the pathogenesis of lung cancer APMIS (IF 2.8) Pub Date : 2023-11-16 Sainan Miao, Huan Qiu
As one of the malignant tumors with high incidence rate and high mortality, lung cancer seriously threatens the life safety of patients. Research shows that microorganisms are closely related to lung cancer. The microbiome is symbiotic with the host and plays a vital role in the functions of the human body. Microbiota dysbiosis is correlated with development of lung cancer. However, the underlying
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Correction to “The relevance of ERG immunoexpression intensity for prostatic adenocarcinoma in radical prostatectomy of 635 samples” APMIS (IF 2.8) Pub Date : 2023-11-16
Feitosa, P.M.F.A, Hirth, C.G., Silva-Fernandes, I.J.D.L. and Dornelas, C.A. (2023). The relevance of ERG immunoexpression intensity for prostatic adenocarcinoma in radical prostatectomy of 635 samples. APMIS, 131: 465–471. https://doi.org/10.1111/apm.13330 The 4th author affiliation were incomplete and have been added. The updated author byline and affiliations are listed below. PRISCILLA MARIANA FREITAS
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Antibiotic resistances of Pseudomonas aeruginosa and Acinetobacter baumannii in urine cultures: experience in a hospital of Southeast Spain APMIS (IF 2.8) Pub Date : 2023-11-16 Horacio Requena-Cabello, Enrique Rodríguez-Guerrero, Manuela Expósito-Ruiz, José María Navarro-Marí, Jose Gutierrez-Fernandez
The objectives of this study were to perform a systematic review of publications between 2010 and 2021 on the antibiotic resistance of Pseudomonas aeruginosa and Acinetobacter baumannii from urinary tract infections and to analyze changes over time in hospital urine cultures from 2016 through 2021. The literature was searched, and a retrospective cross-sectional descriptive study was performed in the
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Human lung vascular endothelium may limit infection with HRV16 via IFN-β-dependent mechanisms APMIS (IF 2.8) Pub Date : 2023-11-16 Mateusz Gawrysiak, Robert Szewczyk, Mateusz Kobierecki, Michał Szymański, Adrian Gajewski, Izabela Gulbas, Sylwia Michlewska, Maciej Chałubiński
Human rhinovirus 16 (HRV16) may induce inflammatory and antiviral responses in the human lung vascular endothelium (ECs) and impair its barrier functions after infection. However, ECs may regain barrier and metabolic functions. Mechanisms of limitation of HRV16 infection in the lung vascular endothelium are unknown. Human lung vascular endothelium (HMVEC-L) was infected with HRV16. IFN-β, OAS-1, and
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Antimicrobial susceptibilities and genomic characteristics of methicillin-resistant Staphylococcus aureus resistant to mupirocin in Stockholm, Sweden APMIS (IF 2.8) Pub Date : 2023-11-15 Nora Vestberg, Mohammad Razavi, Christian G. Giske, Hong Fang
The aim of this study was to investigate antimicrobial susceptibilities and genomic characteristics of mupirocin-resistant MRSA isolates in Stockholm, Sweden. In total, 44 non-duplicate mupirocin-resistant MRSA isolates detected in Stockholm during 2010–2022 were investigated. Antimicrobial susceptibility testing was performed using broth microdilution method and further tested for high-level mupirocin-resistance
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Role and new insights of microfibrillar-associated protein 4 in fibrotic diseases APMIS (IF 2.8) Pub Date : 2023-11-13 Long Zhu, Wenqun Gou, Lijia Ou, Binjie Liu, Manyi Liu, Hui Feng
Fibrosis is one of the most worrisome complications of chronic inflammatory diseases, leading to tissue damage, organ failure, and ultimately, death. The most notable pathological characteristic of fibrosis is the excessive accumulation of extracellular matrix (ECM) components such as collagen and fibronectin adjacent to foci of inflammation or damage. The human microfibrillar-associated protein 4
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Vaginal microecology and its role in human papillomavirus infection and human papillomavirus associated cervical lesions APMIS (IF 2.8) Pub Date : 2023-11-08 Jiatian Ye, Xiaorong Qi
The vaginal microecology comprises the vaginal microbiome, immune microenvironment, vaginal anatomy, and the cervicovaginal fluid, which is rich in metabolites, enzymes, and cytokines. Investigating its role in the female reproductive system holds paramount significance. The advent of next-generation sequencing enabled a more profound investigation into the structure of the vaginal microbial community
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Metabolic syndrome, soluble CD40L, and biomarkers of endothelial dysfunction in people living with HIV APMIS (IF 2.8) Pub Date : 2023-10-17 Mads-Holger B. Jacobsen, Andreas D. Knudsen, Thomas Benfield, Sisse R. Ostrowski, Shoaib Afzal, Edith W. Sørensen, Susanne D. Nielsen, Marco Gelpi
In the present study, we aimed to investigate the association between soluble CD40 ligand (sCD40L, a marker of platelet activation), soluble thrombomodulin, and syndecan-1 (both well-described markers of endothelial dysfunction) and metabolic syndrome in a large cohort of well-treated people with HIV (PWH) and to elucidate their association with HIV-specific variables. We included 862 PWH with undetectable
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Polyphyllin I, a strong antifungal compound against Candida albicans APMIS (IF 2.8) Pub Date : 2023-09-27 Yu Zhang, Jingxiao Zhang, Jian Sun, Min Zhang, Xin Liu, Longfei Yang, Yongjie Yin
This study was performed to explore the antifungal and antibiofilm effects of polyphyllin I (PPI) on Candida albicans. Microdilution assay was performed to determine the minimal inhibitory concentrations (MIC) of PPI against Candida species. Adhesion assay, hyphal growth assay, biofilm formation, and development were used to test the impacts of PPI on C. albicans virulence factors. Propidium iodide
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Does the route matter? A preclinical review of mesenchymal stromal cell delivery to the kidney APMIS (IF 2.8) Pub Date : 2023-09-25 Jean-Claude Kresse, Emil Gregersen, Jasmine Cicek Leifing Atay, Marco Eijken, Rikke Nørregaard
Mesenchymal stromal/stem cell (MSC) therapy has been thoroughly tested in preclinical animal models and holds great promise for the treatment of kidney diseases. It is becoming increasingly evident that the efficacy of MSC therapy is dependent on several factors including dosage, the tissue source of MSCs, the route of delivery and timing of administration. In a time where MSC therapy is moving from
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Single cells and bacterial biofilm populations in chronic wound infections APMIS (IF 2.8) Pub Date : 2023-09-17 Mads Lichtenberg, Klaus Kirketerp-Møller, Lasse A. Kvich, Mads Holm Christensen, Blaine Fritz, Tim Holm Jakobsen, Thomas Bjarnsholt
Chronic wounds and chronic ulcers are an increasing problem associated with high health care burden and patient burden. The arrested healing of chronic wounds has, in part, been attributed to the presence of biofilms. Substantial research has documented the presence of biofilms in chronic wounds, and many mechanisms of host–pathogen interactions have been uncovered to explain the arrested healing.
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Good's syndrome: brief overview of an enigmatic immune deficiency APMIS (IF 2.8) Pub Date : 2023-09-20 Ferenc Sipos, Györgyi Műzes
Good's syndrome, an infrequent adult-onset immunodeficiency is characterized by the triad of thymoma, hypogammaglobulinemia, and increased susceptibility to recurrent infections. The clinical presentation is highly variable, with a spectrum ranging from recurrent bacterial and opportunistic infections to concomitant autoimmune diseases and, sometimes malignant pathologies. Due to heterogeneous clinical
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APMIS focus issue 2023-fungal infections: diagnostics and therapeutics. APMIS (IF 2.8) Pub Date : 2023-09-15 Gordon Ramage,Åse Bengård Andersen
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Are we ready for translational research based on material and data from the Danish CancerBiobank and can we gain new knowledge from biobank registration? APMIS (IF 2.8) Pub Date : 2023-08-31 Estrid V.S. Høgdall, Ib Jarle Christensen, Claus Høgdall
Bio-and GenomeBank, Denmark (RBGB) is a nationwide infra-structure. Danish CancerBiobank (DCB) is a biobank in RBGB. The aim is to describe the degree of biological material collected and stored in DCB for patients diagnosed with primary ovarian cancer registered in The Danish Gynecologic Cancer Database (DGCD). Furthermore, to investigate the concordance between predicted organ of disease registered
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No evidence of increased anti-M3 muscarinic acetylcholine receptor autoantibodies in SSA-positive connective tissue disease patients APMIS (IF 2.8) Pub Date : 2023-08-24 Elif Hatipoğlu, Jakob Hauge Mikkelsen, Trine-Line Korsholm, Malene Hvid, Bent Deleuran, Marie Louise Næstholt Dahl
Anti-muscarinic type 3 receptor autoantibodies (M3R) and anti-SSA antibodies are both related to salivary secretion. The presence of M3R antibodies in Sjögren's syndrome is previously demonstrated; nevertheless, the relationship between the anti-SSA antibodies and M3R fragment antibodies, namely the N terminal, first, second, and third extracellular loops, remains to be elucidated. In this study, we
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Web-grading—a tool to test personal grading of renal and prostate cancer APMIS (IF 2.8) Pub Date : 2023-08-24 Glen Kristiansen, Matthias Schmid, Lars Egevad, Hemamali Samaratunga, Murali Varma, Kaan Inam, Hans-Jürgen Thiesen, Brett Delahunt, Yulin Dai
Only a few pathologists have the opportunity to verify their personal grading through objective assessment. This study introduces a web-based grading platform to facilitate and validate the grading of renal cell carcinoma and prostate cancer. Two representative images of two clinically annotated cohorts of 100 cases each of prostate and renal cell carcinoma were used. Each participant was asked to
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Prevalence, molecular markers, and outcome of bronchial squamous carcinoma in situ in high-risk subjects APMIS (IF 2.8) Pub Date : 2023-08-23 Steinn Jonsson, Wilbur A. Franklin, Marileila Varella-Garcia, Timothy C. Kennedy, Daniel Merrick, Kathryn D. Matney, Gudrun N. Oskarsdottir, Arni Saemundsson, Robert L. Keith, Paul A. Bunn, York E. Miller
Bronchial squamous carcinoma in situ (CIS) is a preinvasive lesion that is thought to precede invasive carcinoma. We conducted prospective autofluorescence and white light bronchoscopy trials between 1992 and 2016 to assess the prevalence, molecular markers, and outcome of individuals with CIS and other preneoplastic bronchial lesions. Biopsies were evaluated at multiple levels and selected biopsies
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Performance of automated antimicrobial susceptibility testing for the detection of antimicrobial resistance in gram-negative bacteria: a NordicAST study APMIS (IF 2.8) Pub Date : 2023-08-17 Truls M. Leegaard, Ulrik S. Justesen, Erika Matuschek, Christian G. Giske
Automated testing of antimicrobial susceptibility is common in clinical microbiology laboratories but their ability to detect low-level resistance has been questioned. This Nordic multicentre study aimed to evaluate the performance of commercially available automated AST systems. A phenotypically well-characterised collection of gram-negative bacilli (Escherichia coli (n = 7), Klebsiella pneumoniae