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Factors influencing spontaneous hypothermia after emergency trauma and the construction of a predictive model Open Life Sci. (IF 2.2) Pub Date : 2024-04-20 Xia Feng, Fangxiang Zhu, Anhua Qiao, Wenfang Li, Ying Jiang, Zengtao Han, Lan Dong
This study aimed to investigate spontaneous hypothermia among emergency trauma patients and develop a predictive model. A cohort of 162 emergency trauma patients was categorized into hypothermic (n = 61) and control (n = 101) groups, with trauma severity assessed using the modified Glasgow Coma Scale (GCS). Univariate analysis revealed significant differences between the groups in trauma severity,
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Long-term administration of morphine specifically alters the level of protein expression in different brain regions and affects the redox state Open Life Sci. (IF 2.2) Pub Date : 2024-04-20 Lucie Hejnova, Anna Hronova, Zdenka Drastichova, Jiri Novotny
We investigated the changes in redox state and protein expression in selected parts of the rat brain induced by a 4 week administration of morphine (10 mg/kg/day). We found a significant reduction in lipid peroxidation that mostly persisted for 1 week after morphine withdrawal. Morphine treatment led to a significant increase in complex II in the cerebral cortex (Crt), which was accompanied by increased
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VSP-2 attenuates secretion of inflammatory cytokines induced by LPS in BV2 cells by mediating the PPARγ/NF-κB signaling pathway Open Life Sci. (IF 2.2) Pub Date : 2024-04-20 Jingxin Cui, Liwei Xu, Yimeng Sun, Lingfei Dai, Yuxiu Mo, Keli Yun, Yifei Chen, Linglin Chen
Neuroinflammation, characterized by microglial activation and the subsequent secretion of inflammatory cytokines, plays a pivotal role in neurodegenerative diseases and brain injuries, often leading to neuronal damage and death. Alleviating neuroinflammation has thus emerged as a promising strategy to protect neurons and ameliorate neurodegenerative disorders. While peroxisome proliferator-activated
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Distribution of CYP2D6 and CYP2C19 gene polymorphisms in Han and Uygur populations with breast cancer in Xinjiang, China Open Life Sci. (IF 2.2) Pub Date : 2024-04-20 Muzhapaer Abudukeremu, Aisikaer Ayoufu, Adila Tuerhong, Xuelaiti Paizula, Jiang-Hua Ou
The aim of this study was to investigate the frequency distribution of the cytochrome P450 (CYP450) enzymes, CYP2D6 and CYP2C19, and the form of tamoxifen metabolisation in premenopausal patients with breast cancer in the Han and Uygur ethnic groups of Xinjiang to guide rational clinical drug use. A total of 125 Han patients and 121 Uygur patients with premenopausal hormone-receptor-positive breast
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Mitigating digestive disorders: Action mechanisms of Mediterranean herbal active compounds Open Life Sci. (IF 2.2) Pub Date : 2024-04-18 Abdalsalam Kmail
This study explores the effects of the Mediterranean diet, herbal remedies, and their phytochemicals on various gastrointestinal conditions and reviews the global use of medicinal plants for common digestive problems. The review highlights key plants and their mechanisms of action and summarizes the latest findings on how plant-based products influence the digestive system and how they work. We searched
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The effects of SDF-1 combined application with VEGF on femoral distraction osteogenesis in rats Open Life Sci. (IF 2.2) Pub Date : 2024-04-17 Fangang Fu, Mengqi Li, Shuye Yang, Gangqiang Du, Yingjiang Xu, Jianhao Jiang, Long Jia, Kai Zhang, Peng Li
Bone regeneration and mineralization can be achieved by means of distraction osteogenesis (DO). In the present study, we investigated the effect of stromal cell-derived factor 1 (SDF-1) and vascular endothelial growth factor (VEGF) on the new bone formation during DO in rats. Forty-eight Sprague–Dawley rats were randomized into four groups of 12 rats each. We established the left femoral DO model in
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Absorbable calcium and phosphorus bioactive membranes promote bone marrow mesenchymal stem cells osteogenic differentiation for bone regeneration Open Life Sci. (IF 2.2) Pub Date : 2024-04-17 Lei Huang, Zhuorun Song, Jiayi Wang, Mengxuan Bian, Jiapeng Zou, Yanpei Zou, Jun Ge, Shunyi Lu
Large segmental bone defects are commonly operated with autologous bone grafting, which has limited bone sources and poses additional surgical risks. In this study, we fabricated poly(lactide-co-glycolic acid) (PLGA)/β-tricalcium phosphate (β-TCP) composite membranes by electrostatic spinning and further promoted osteogenesis by regulating the release of β-TCP in the hope of replacing autologous bone
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Fabrication and characterization of gold nanoparticles using alginate: In vitro and in vivo assessment of its administration effects with swimming exercise on diabetic rats Open Life Sci. (IF 2.2) Pub Date : 2024-04-17 Vahideh Hashemzadeh, Alireza Hashemzadeh, Reza Mohebbati, Reza Gharari Arefi, Mohammad Ehsan Taghavizadeh Yazdi
Gold nanoparticles (AuNPs) have unique features that might lead to the development of a new class of diabetic medicines. AuNPs were biosynthesized utilizing sodium-alginate. UV-Vis-spectroscopy, Fourier transforms infrared, field emission scanning electron microscopy (FESEM), and energy dispersive X-ray were used to examine the particles. The potential of AuNPs for improving the diabetes condition
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Sample size estimation for AQP4-IgG seropositive optic neuritis: Retinal damage detection by optical coherence tomography Open Life Sci. (IF 2.2) Pub Date : 2024-04-16 Shuwen Lu, Chao Ma, Yi Du
We recruited four aquaporin-4 seropositive optic neuritis patients (five eyes) who received glucocorticoid treatment and underwent optical coherence tomography examination. Baseline medians of the macular ganglion cell layer plus inner plexiform layer (mGCIPL) thickness and volume for the eye of interest were 79.67 µm (73.664 ± 18.497 µm) and 0.58 mm3 (0.534 ± 0.134 mm3), respectively. At 2 months
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Highly specific vaginal microbiome signature for gynecological cancers Open Life Sci. (IF 2.2) Pub Date : 2024-04-16 Mengzhen Han, Na Wang, Wenjie Han, Xiaolin Liu, Tao Sun, Junnan Xu
To investigate the vaginal microbiota signature of patients with gynecologic cancer and evaluate its diagnostic biomarker potential. We incorporated vaginal 16S rRNA-seq data from 529 women and utilized VSEARCH to analyze the raw data. α-Diversity was evaluated utilizing the Chao1, Shannon, and Simpson indices, and β-diversity was evaluated through principal component analysis using Bray-Curtis distances
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Transcriptome analysis reveals the mechanism of NaHCO3 promoting tobacco leaf maturation Open Life Sci. (IF 2.2) Pub Date : 2024-04-15 Tingting Wang, Yuanyuan Zhao, Dexun Wang, Hongzhi Shi
NaHCO3 accelerates the aging of tobacco leaves; however, the underlying molecular mechanisms have not been elucidated. This study aimed to explore the mechanism of NaHCO3 in the promotion of tobacco leaf maturation using transcriptome analysis. Leaves on plants or detached leaves of the tobacco variety, Honghua Dajinyuan, were sprayed with or without 1% NaHCO3. The leaf yellowing was observed, the
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Microbial perspective on the skin–gut axis and atopic dermatitis Open Life Sci. (IF 2.2) Pub Date : 2024-04-13 Bo Qu, Xue-er Zhang, Haoyue Feng, Bonan Yan, Yingchun Bai, Shanlin Liu, Yuhua He
Atopic dermatitis (AD) is a relapsing inflammatory skin condition that has become a global health issue with complex etiology and mounting prevalence. The association of AD with skin and gut microbiota has been revealed by virtue of the continuous development of sequencing technology and genomics analysis. Also, the gut–brain–skin axis and its mutual crosstalk mechanisms have been gradually verified
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Thymosin α1 combined with XELOX improves immune function and reduces serum tumor markers in colorectal cancer patients after radical surgery Open Life Sci. (IF 2.2) Pub Date : 2024-04-13 Li Sha, Hao Zhang, Xiwei Zhang
This study aimed to investigate the efficacy of thymosin α1 combined with XELOX in improving immune function and reducing serum tumor markers in patients with colorectal cancer (CRC) after radical surgery. A total of 180 patients who underwent radical surgery for CRC were divided into two groups: an observation group (n = 94) receiving thymosin α1 in combination with XELOX and a control group (n =
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Identification of KDM4C as a gene conferring drug resistance in multiple myeloma Open Life Sci. (IF 2.2) Pub Date : 2024-04-12 Na Zhang, Ruilong Lan, Yingyu Chen, Jianda Hu
Bortezomib (BTZ), a proteasome inhibitor, is a promising therapeutic option for multiple myeloma (MM) patients. However, drug resistance often occurs, leading to disease relapse and poor prognosis. In this study, we aimed to identify novel genes associated with drug resistance and investigate their roles in BTZ resistance. Through the screening of 26 genes frequently associated with chemosensitivity
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P2X7 receptor: A receptor closely linked with sepsis-associated encephalopathy Open Life Sci. (IF 2.2) Pub Date : 2024-04-05 Zhao Fan, Kaifang Wang, Xiaoyong Zhao, Xude Sun
Sepsis is defined as a dysregulated host response to infection resulting in life-threatening organ dysfunction. Sepsis-associated encephalopathy (SAE) is the main manifestation of sepsis. Inflammation, peroxidation stress injury, and apoptosis are the main factors involved in the pathogenesis of SAE. A growing body of evidence has proved that P2X7 receptor (P2X7R), a cationic channel receptor that
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Probiotics for inflammatory bowel disease: Is there sufficient evidence? Open Life Sci. (IF 2.2) Pub Date : 2024-04-05 Yueying Ma, Dandan Yang, Jin Huang, Kunli Liu, Huirong Liu, Huangan Wu, Chunhui Bao
Inflammatory bowel disease (IBD) refers to chronic inflammatory disorders of the gut. Ulcerative colitis (UC) and Crohn’s disease (CD) are two subtypes of IBD. Evidence suggests that the intestinal microbiota plays a role in the pathogenesis of IBD, so probiotics have garnered a lot of interest as a potential treatment or prevention for IBD. However, clinical evidence of the efficacy of probiotics
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Carrying SNP rs17506395 (T > G) in TP63 gene and CCR5Δ32 mutation associated with the occurrence of breast cancer in Burkina Faso Open Life Sci. (IF 2.2) Pub Date : 2024-04-03 Lassina Traoré, Mousso Savadogo, Abdou Azaque Zouré, Touwendpoulimdé Isabelle Kiendrebeogo, Fabienne Marie B. T. B. Soudre, Soayebo Dabre, Aida Djé Djénéba Traore, Marc Donald Wilfried Adico, Tilate Lare, Teega-Wendé Clarisse Ouedraogo, Rogomenoma Alice Ouedraogo, Abdoul Karim Ouattara, Edwige T. Yelemkoure, Alexis Yobi Sawadogo, Nayi Zongo, Hierrhum Aboubacar Bambara, Christelle W. Nadembega, Florencia
Genetic alterations in the TP63 (GenBank: NC_000003.12, ID: 8626) and CCR5 (receptor 5 chemokine co-receptor) (GenBank: NC_000003.12, ID: 1234) genes may increase the risk of developing breast cancer. The aim of this study was to investigate the probable involvement of polymorphisms rs17506395 in the TP63 (tumour protein 63) gene and the CCR5Δ32 mutation in the occurrence of breast cancer in Burkina
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Enhancing faba bean (Vicia faba L.) productivity through establishing the area-specific fertilizer rate recommendation in southwest Ethiopia Open Life Sci. (IF 2.2) Pub Date : 2024-04-02 Berhanu Bilate Daemo
The aim of this study is to establish area-specific NPSB (18.9% N, 37.7% P2O5, 6.95% S, and 0.1% B) fertilizer rate recommendations for the optimal grain yield of faba bean. The field experiment was conducted in two locations in the 2021 and 2022 cropping seasons using a randomized complete block design with three replications. The nine treatments included 0, 25, 50, 75, 100, 125, 150, 175, and 200
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The predictive value of serum NLR, SII, and OPNI for lymph node metastasis in breast cancer patients with internal mammary lymph nodes after thoracoscopic surgery Open Life Sci. (IF 2.2) Pub Date : 2024-04-01 Yang Li, Yang Fei
In this research, we delved into the predictive potential of three key markers – the neutrophil-to-lymphocyte ratio (NLR), systemic immune inflammation index (SII), and Onodera’s prognostic nutritional index (OPNI), in assessing lymph node metastases in breast cancer patients who had internal mammary lymph node involvement following thoracoscopic surgery. Our study revealed notable pathological distinctions
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Exploration of the genetic influence of MYOT and MB genes on the plumage coloration of Muscovy ducks Open Life Sci. (IF 2.2) Pub Date : 2024-04-01 Guo-Bo Sun, Yan-Feng Lu, Xiu-Jun Duan
Plumage color, a pivotal attribute delineating diverse Muscovy duck strains, assumes considerable significance within the field of Muscovy duck breeding research. This study extends the existing research by delving into the hereditary aspects of genes associated with plumage coloration in Muscovy ducks. The principal objective is to discern marker genes conducive to targeted breeding strategies based
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IL-33/soluble ST2 axis is associated with radiation-induced cardiac injury Open Life Sci. (IF 2.2) Pub Date : 2024-03-30 Xiaokeya Yasen, Renaguli Aikebaier, Atiguli Maimaiti, Munire Mushajiang
Radiotherapy for treating breast cancer is associated with cardiac damage. This study aimed to investigate the role of the interleukin (IL)-33/soluble receptor ST2 (sST2) axis in radiation-induced cardiac injury. Expressions of IL-33 and sST2 were detected in breast cancer patients following radiotherapy, radiation-induced cardiac damaged mice model, and cardiomyocytes using quantitative real-time
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Helicobacter pylori causes gastric dysbacteriosis in chronic gastritis patients Open Life Sci. (IF 2.2) Pub Date : 2024-03-28 Chao Cen, Qiuying Du, Bin Luo, Tonghua Wang, Jianwei Su, Xiaoshan Qin, Wenyan Zhang, Lijing Lu, Yang Liao, Yanqiang Huang, Yumei Liang
Gastric mucosal samples were procured and underwent the sequencing of 16S ribosomal RNA (16S rRNA) via Illumina high-throughput sequencing technology to explore the impact of Helicobacter pylori (H. pylori) infection on the composition of gastric flora in chronic gastritis (CG) patients. In the results, the operational taxonomic unit (OTU) analysis revealed an overlap of 5706 OTUs shared between the
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Exploring antioxidant strategies in the pathogenesis of ALS Open Life Sci. (IF 2.2) Pub Date : 2024-03-28 Víctor Pinilla-González, Benjamin Montecinos-Barrientos, Clemente Martin-Kommer, Silvia Chichiarelli, Luciano Saso, Ramón Rodrigo
The central nervous system is essential for maintaining homeostasis and controlling the body’s physiological functions. However, its biochemical characteristics make it highly vulnerable to oxidative damage, which is a common factor in neurodegenerative diseases like amyotrophic lateral sclerosis (ALS). ALS is a leading cause of motor neuron disease, characterized by a rapidly progressing and incurable
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KAT2A changes the function of endometrial stromal cells via regulating the succinylation of ENO1 Open Life Sci. (IF 2.2) Pub Date : 2024-03-28 Kangkang Zeng, Hao Yin
Endometriosis is increasingly affecting women worldwide and research is focusing on identifying key targets in its pathogenesis. Changes in succinylation genes regulate the function of this protein and further influence the development of the disease. However, the role of succinylation genes in endometriosis is not clear from current studies. The expression of succinylation genes was determined in
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Current state of research on copper complexes in the treatment of breast cancer Open Life Sci. (IF 2.2) Pub Date : 2024-03-28 Kui Hu, Jingna Guo, Jiemin Zeng, Yunhao Shao, Binhua Wu, Jian Mo, Guixi Mo
Breast cancer, a malignancy originating from the epithelium or ductal epithelium of the breast, is not only highly prevalent in women but is also the leading cause of cancer-related deaths in women worldwide. Research has indicated that breast cancer incidence is increasing in younger women, prompting significant interest from scientists actively researching breast cancer treatment. Copper is highly
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Development of a detection chip for major pathogenic drug-resistant genes and drug targets in bovine respiratory system diseases Open Life Sci. (IF 2.2) Pub Date : 2024-03-26 Jie Qi, Penghui Li, Yasong Yan, Gongmei Li, Lingcong Kong
Bovine respiratory disease (BRD) is a significant veterinary challenge, often exacerbated by pathogen resistance, hindering effective treatment. Traditional testing methods for primary pathogens – Mycoplasma bovis, Pasteurella multocida, and Mannheimia haemolytica – are notably time-consuming and lack the rapidity required for effective clinical decision-making. This study introduces a TaqMan MGB probe
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Reexamination of Aspergillus cristatus phylogeny in dark tea: Characteristics of the mitochondrial genome Open Life Sci. (IF 2.2) Pub Date : 2024-03-26 Hu Zhiyuan, Chen Lin, Wang Yihan, Dong Meng, Li Yanzi, Xu Zhenggang
To enhance our understanding of Aspergillus cristatus, an important functional microorganism, the characteristics of its mitochondrial genome were analyzed and compared with related species. The mitochondrial genome of A. cristatus was determined to be 77,649 bp in length, with 15 protein-coding regions. Notably, its length surpassed that of the other species, primarily attributable to the intron length
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Apigenin 7-glucoside impedes hypoxia-induced malignant phenotypes of cervical cancer cells in a p16-dependent manner Open Life Sci. (IF 2.2) Pub Date : 2024-03-21 Yan Li, Xiaoli Man, Qing Zhang, Xiaowu Wang, Yongli Yang
Apigenin 7-glucoside (A7G) can suppress cell proliferation and trigger apoptosis in cervical cancer cells. Considering that hypoxia is associated with the malignant phenotypes in cervical cancer, this study aimed to uncover whether A7G exhibits suppressive effects on the hypoxia-induced malignant phenotype of cervical cancer cells (HeLa cells). Compared to normoxia, hypoxia can enhance the malignant
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Sirtuin 5 regulates acute myeloid leukemia cell viability and apoptosis by succinylation modification of glycine decarboxylase Open Life Sci. (IF 2.2) Pub Date : 2024-03-16 Jun Zhang, Cheng Luo, Haiying Long
Acute myeloid leukemia (AML) is a blood system malignancy where sirtuin 5 (SIRT5) is abnormally expressed in AML cell lines. This study aimed to investigate the SIRT5 effects on the viability and apoptosis of AML cell lines. The mRNA and protein expression levels of succinylation regulatory enzyme in clinical samples and AML cell lines were detected by real-time quantitative polymerase chain reaction
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Evaluation of the impact of two citrus plants on the variation of Panonychus citri (Acari: Tetranychidae) and beneficial phytoseiid mites Open Life Sci. (IF 2.2) Pub Date : 2024-03-16 Amine Assouguem, Abdelmalek Boutaleb Joutei, Rachid Lahlali, Mohammed Kara, Ahmed Bari, Essam A. Ali, Hafize Fidan, Hajar Zine Laabidine, Younouss El Ouati, Abdellah Farah, Abderrahim Lazraq
The abundance of Panonychus citri McGregor 1916 (Acari: Tetranychidae) and its associated enemies (Euseius stipulatus Athias-Henriot, 1960; Typhlodromus sp.; Phytoseiulus persimilis Athias-Henriot, 1957) was studied on two 12-year-old citrus cultivars, specifically Clementine “Nules” (Citrus Clementina) and Valencia (Citrus sinensis), in the Gharb region of Morocco. Throughout the entire monitoring
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Knockdown of ANP32E inhibits colorectal cancer cell growth and glycolysis by regulating the AKT/mTOR pathway Open Life Sci. (IF 2.2) Pub Date : 2024-03-10 Jiaojiao Liu, Yanchao Liu, Qi Zhao
Colorectal cancer (CRC) is the third most common tumor, with an increasing number of deaths worldwide each year. Tremendous advances in the diagnosis and treatment of CRC have significantly improved the outcomes for CRC patients. Additionally, accumulating evidence has hinted the relationship between acidic nuclear phosphoprotein 32 family member E (ANP32E) and cancer progression. But the role of ANP32E
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Kaempferol regulates apoptosis and migration of neural stem cells to attenuate cerebral infarction by O‐GlcNAcylation of β-catenin Open Life Sci. (IF 2.2) Pub Date : 2024-03-10 Song Zhang, Honglei Jiao
Ischemic stroke remains a major cause of disability and death. Kaempferol (Kae) is a neuroprotective flavonoid compound. Thus, this study aimed to explore the impact of Kae on cerebral infarction. We generated the middle cerebral artery occlusion (MCAO) mouse model to study the effects of Kae on infarction volume and neurological function. The oxygen and glucose deprivation (OGD)/reoxygenation (R)
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Photosynthetic physiological characteristics, growth performance, and element concentrations reveal the calcicole–calcifuge behaviors of three Camellia species Open Life Sci. (IF 2.2) Pub Date : 2024-03-10 Shengfeng Chai, Haidu Jiang, Yishan Yang, Xinfeng Pan, Rong Zou, Jianmin Tang, Zongyou Chen, Danjuan Zeng, Xiao Wei
We grew three yellow Camellia species (the calcifuge C. nitidissima and C. tunghinensis, and the calcicole C. pubipetala) in acidic and calcareous soils for 7 months and assessed their photosynthetic physiological characteristics, growth performance, and element concentrations in this developmental context. The calcifuge C. nitidissima and C. tunghinensis species exhibited poor growth with leaf chlorosis
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Detection of serum interleukin-18 level and neutrophil/lymphocyte ratio in patients with antineutrophil cytoplasmic antibody-associated vasculitis and its clinical significance Open Life Sci. (IF 2.2) Pub Date : 2024-03-06 Changning Liu
Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a group of autoimmune diseases. This study aimed to investigate the clinical significance of changes in interleukin-18 (IL-18) and neutrophil/lymphocyte ratio (NLR) in the pathogenesis of AAV and the impact of NLR on the prognosis of patients. The clinical data of 52 AAV patients (AAV group) who met the conditions of hospitalization
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Application of the integrated airway humidification device enhances the humidification effect of the rabbit tracheotomy model Open Life Sci. (IF 2.2) Pub Date : 2024-03-06 Honglan Sheng, Jie Ni, Feng Zhao, Mi Tian, Yuhang Zhao, Longmei Dai, Ting Li, Yun Xue, Zongze Song, Qiong Yu
Long-term mechanical ventilation after tracheotomy is a common treatment in intensive care unit patients. This study investigated the differences among the effects of different wetting states on the airway, lung, and serum inflammatory factors. New Zealand rabbits (n = 36) were selected to construct tracheotomy models and then divided into four groups: Model, Mask, YTH, and Sham groups. Lung tissue
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Degradation of a mixture of 13 polycyclic aromatic hydrocarbons by commercial effective microorganisms Open Life Sci. (IF 2.2) Pub Date : 2024-03-06 Paulina Książek-Trela, Damian Figura, Dominika Węzka, Ewa Szpyrka
The study focused on the contribution of effective microorganisms (EM) and their consortia, used in commercial biological preparations and formulations for soil revitalization, to the degradation of a mixture of 13 polycyclic aromatic hydrocarbons (PAHs) commonly found in the soil environment. PAHs, diverse forms of which are present in the environment, never occur individually but always as a part
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Gut microbiota changes associated with low-carbohydrate diet intervention for obesity Open Life Sci. (IF 2.2) Pub Date : 2024-03-06 Li Li, Xiaoguo Zhao, Rashidin Abdugheni, Feng Yu, Yunyun Zhao, Ba-Fang Ma, Zhifang Yang, Rongrong Li, Yue Li, Yasen Maimaitiyiming, Mayila Maimaiti
Low-carbohydrate diets (LCDs) are frequently recommended for alleviating obesity, and the gut microbiota plays key roles in energy metabolism and weight loss. However, there is limited in-human research on how LCD changes gut microbiota. In this before–after study, 43 participants were assigned to the LCD intervention for 4 weeks. The main objective was to investigate the specific changes that occur
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Pheochromocytoma-induced myocardial infarction: A case report Open Life Sci. (IF 2.2) Pub Date : 2024-02-24 Haixia Tang, Jichun Liu, Bangsheng Hu, Yuwen Yang, Xiangrong Xie, Youquan Wei
The pheochromocytoma is an uncommon endocrine neoplasm that originates from chromaffin cells and causes significant cardiovascular effects through the intermittent or sustained release of catecholamines. In this report, we present a rare case of myocardial infarction (MI) induced by pheochromocytoma. A 53-year-old female presented to the emergency department with a history of intermittent palpitations
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Transplantation of human neural stem cell prevents symptomatic motor behavior disability in a rat model of Parkinson’s disease Open Life Sci. (IF 2.2) Pub Date : 2024-02-24 Fen Wang, Xiao-Yu Cheng, Yu-Ting Zhang, Qing-Ran Bai, Xiao-Qi Zhang, Xi-Cai Sun, Quan-Hong Ma, Xiong-Fei Zhao, Chun-Feng Liu
Parkinson’s disease (PD) is a ubiquitous brain cell degeneration disease and presents a significant therapeutic challenge. By injecting 6-hydroxydopamine (6-OHDA) into the left medial forebrain bundle, rats were made to exhibit PD-like symptoms and treated by intranasal administration of a low-dose (2 × 105) or high-dose (1 × 106) human neural stem cells (hNSCs). Apomorphine-induced rotation test,
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Single-nucleotide polymorphism rs2910829 in PDE4D is related to stroke susceptibility in Chinese populations: The results of a meta-analysis Open Life Sci. (IF 2.2) Pub Date : 2024-02-23 Guiying Zhang, Xuelei Tang, Qifu Li, Rong Lin
Stroke is a debilitating condition that often leads to disability and death. The increasing prevalence of stroke has drawn worldwide attention. Extensive evidence indicates a crucial role of genetic determinants in the occurrence and perpetuation of stroke. An Icelandic study identified a significant correlation of the phosphodiesterase 4D (PDE4D) single-nucleotide polymorphism (SNP) rs2910829 with
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Current research and evidence gaps on placental development in iron deficiency anemia Open Life Sci. (IF 2.2) Pub Date : 2024-02-21 Shaoyang Lai, Weiwei Yu, Ying Liu, Yuxin Yang, Xueqin Zhang
Studying the effects of maternal iron deficiency anemia (IDA) is complex owing to its diverse causes, each independently impacting the placenta and fetus. Simple treatment with iron supplements does not always resolve the anemia. Therefore, delving into how IDA alters placental development at a molecular level is crucial to further optimize treatment. This review addresses the effects of IDA on placental
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Aquaporin-8 promotes human dermal fibroblasts to counteract hydrogen peroxide-induced oxidative damage: A novel target for management of skin aging Open Life Sci. (IF 2.2) Pub Date : 2024-02-16 Shu-Hsiang Liu, Wei-Chun Lin, En-Chih Liao, Yung-Feng Lin, Ching-Shuen Wang, Sheng-Yang Lee, Dee Pei, Chun-Hsien Hsu
The skin is subjected to various external factors that contribute to aging including oxidative stress from hydrogen peroxide (H2O2). This study investigated the distribution of aquaporin-8 (AQP8), a protein that transports H2O2 across biological membranes, in skin cells, and its effects in mitigating H2O2-induced oxidative damage. Human dermal fibroblasts were treated with increasing concentrations
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Ang-1, Ang-2, and Tie2 are diagnostic biomarkers for Henoch-Schönlein purpura and pediatric-onset systemic lupus erythematous Open Life Sci. (IF 2.2) Pub Date : 2024-02-08 Lishan Jia, Xiaozhong Li, Jiayun Shen, Yan Teng, Baoqin Zhang, Min Zhang, Yueqin Gu, Hong Xu
Henoch-Schönlein purpura (HSP) and pediatric-onset systemic lupus erythematosus (pSLE) are closely associated with vasculitis and vascular diseases. This study aimed to investigate the clinical diagnostic values of Ang-1, Ang-2, and Tie2 for HSP and pSLE. We surveyed 82 HSP patients, 34 pSLE patients, and 10 healthy children. The expression levels of Ang-1, Ang-2, and Tie2 in the serum and urine were
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Preparation of Cu2+/TA/HAP composite coating with anti-bacterial and osteogenic potential on 3D-printed porous Ti alloy scaffolds for orthopedic applications Open Life Sci. (IF 2.2) Pub Date : 2024-02-08 Xu Haitao, Li Siyuan, Guo Sutong, Guo Yu, Xu Peirong, Wang Ling, Ding Yujian, Feng Dehong
Because of stress shielding effects, traditional titanium (Ti) alloy scaffolds have a high elastic modulus, which might promote looseness and bone disintegration surrounding the implant, increasing the likelihood of a second surgery. In contrast, 3D-printed porous Ti alloy scaffolds can reduce the scaffold weight while enhancing biocompatibility. Further, these scaffolds’ porous nature allows bone
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Effectiveness and safety of a mumps containing vaccine in preventing laboratory-confirmed mumps cases from 2002 to 2017: A meta-analysis Open Life Sci. (IF 2.2) Pub Date : 2024-02-08 Bu-Gang Gao, Ling-feng Huang, Ping Xie
Emerging evidence has figured that serum conversion rate of mumps is a crucial link of mumps disease. Nevertheless, a rising number of mumps outbreaks caused our attention and studies examining the serum conversion cases were conducted in small samples previously; this meta-analysis was conducted to assess the immunogenicity and safety of a mumps containing vaccine (MuCV) before 2019. We identified
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Role of serum B-cell-activating factor and interleukin-17 as biomarkers in the classification of interstitial pneumonia with autoimmune features Open Life Sci. (IF 2.2) Pub Date : 2024-02-08 Lihong Zhao, Li Liu, Yehua Liu, Hong Zheng, Ping Jiang
Interstitial pneumonia with autoimmune features (IPAF) is a type of interstitial lung disease (ILD) with immune features that do not meet the diagnostic criteria for specific connective tissue diseases (CTDs). This retrospective case–control study investigated the role of serum B-cell-activating factor of the tumor necrosis factor family (BAFF) and interleukin (IL)-17 as biomarkers for IPAF. The differences
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A case of Trousseau syndrome: Screening, detection and complication Open Life Sci. (IF 2.2) Pub Date : 2024-02-08 Hui Liu, Meng Jiang, Nan Wu, Qingxin Liu, Xueli Fan
Trousseau syndrome (TS) is a malignant tumor-mediated complication of the hypercoagulable state with an unknown etiology. Laboratory testing results in patients with TS have indicated elevated D-dimer levels. The imaging analysis in patients who had undergone stroke has shown the presence of several cerebral infarction lesions in multiple regions. Since patients have had malignant tumors for a long
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PTTG1 induces pancreatic cancer cell proliferation and promotes aerobic glycolysis by regulating c-myc Open Life Sci. (IF 2.2) Pub Date : 2024-02-08 Yong Wang, Jianping Hu, Chen Chen, Yongbo Li
This study aimed to clarify the role of pituitary tumor-transforming gene 1 (PTTG1) in proliferation, migration, invasion, and aerobic glycolysis of pancreatic cancer cells, and evaluate the potential of PTTG1 as a therapeutic target. PTTG1 expression in pancreatic cancers was analyzed using the GEPIA databank. In the Panc1 cell with the PTTG1 knockdown or Mia-PaCa2 cells with PTTG1 overexpression
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Low levels of sex hormone-binding globulin predict an increased breast cancer risk and its underlying molecular mechanisms Open Life Sci. (IF 2.2) Pub Date : 2024-02-08 Shuhang Zhao, Jiaojiao Gu, Yu Tian, Ruoyan Wang, Wentao Li
Sex hormone-binding globulin (SHBG) is a serum glycoprotein exhibiting the unique feature of binding sex steroids with high affinity and specificity. Over the past few decades, there have been significant breakthroughs in our understanding of the function and regulation of SHBG. The biological role of SHBG has expanded from being considered a simple sex hormone transporter to being associated with
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Brucella infection combined with Nocardia infection: A case report and literature review Open Life Sci. (IF 2.2) Pub Date : 2024-02-03 Yan Feng, Chun-Lei Zuo, Jia-Xin Shi
Human brucellosis is an infectious disease caused by Brucella and is often misdiagnosed for atypical manifestations including fever of unknown origin, headache, weakness, among else. Nocardiosis is a zoonotic disease caused by the genus Nocardia, which usually spreads through the respiratory tract, skin, and digestive tract. Limited research has documented cases of co-infection involving both Brucella
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The role and mechanism of esketamine in preventing and treating remifentanil-induced hyperalgesia based on the NMDA receptor–CaMKII pathway Open Life Sci. (IF 2.2) Pub Date : 2024-01-31 Jiafang Wang, Yankun Feng, Zhong Qi, Jin Li, Zhijun Chen, Jinming Zhang, Degang Zhu
Remifentanil-induced hyperalgesia (RIH) is a common clinical phenomenon that limits the use of opioids in pain management. Esketamine, a non-competitive N-methyl-d-aspartate (NMDA) receptor antagonist, has been shown to prevent and treat RIH. However, the underlying effect mechanism of esketamine on RIH remains unclear. This study aimed to investigate the role and mechanism of esketamine in preventing
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Effect of long-term in-row branch covering on soil microorganisms in pear orchards Open Life Sci. (IF 2.2) Pub Date : 2024-01-29 Minghui Ji, Jintao Xu, Lijuan Gao, Longfei Li, Huan Liu, Baofeng Hao
Branches covering (BC) is a way to reuse the pruned branches and save the cost of ground cloth. This study investigated the effects of BC and ground-cloth covering on the soil microcosm environment by measuring the chemical properties and microbial communities at different soil depths for 6 years. The results revealed that BC significantly improved soil chemical properties, increased the abundance
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Research progress on ocular complications caused by type 2 diabetes mellitus and the function of tears and blepharons Open Life Sci. (IF 2.2) Pub Date : 2024-01-27 Xiaohong Wang, Jian Fang, Lina Yang
The purpose of this study was to explore the related research progress of ocular complications (OCs) caused by type 2 diabetes mellitus (T2DM), tear and tarsal function, and the application of deep learning (DL) in the diagnosis of diabetes and OCs caused by it, to provide reference for the prevention and control of OCs in T2DM patients. This study reviewed the pathogenesis and treatment of diabetes
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Screening of different growth conditions of Bacillus subtilis isolated from membrane-less microbial fuel cell toward antimicrobial activity profiling Open Life Sci. (IF 2.2) Pub Date : 2024-01-24 Dharni Kuhan Sreedharan, Hartini Alias, Muaz Mohd Zaini Makhtar, Tan Joo Shun, Ana Masara Ahmad Mokhtar, Hafiza Shukor, Masoom Raza Siddiqui, Mahboob Alam, Riti Thapar Kapoor, Mohd Rafatullah
Bacteriocins produced by Bacillus subtilis have gained recognition for their safe use in humans. In this study, we aimed to assess the inhibitory activity of an antimicrobial peptide synthesized by the wild-type strain of B. subtilis against the notorious pathogen Pseudomonas aeruginosa. Our investigation employed the broth microdilution method to evaluate the inhibitory potential of this peptide.
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PEGylated porcine–human recombinant uricase: A novel fusion protein with improved efficacy and safety for the treatment of hyperuricemia and renal complications Open Life Sci. (IF 2.2) Pub Date : 2024-01-24 Xiangyan Wang, Hao Lu, Jun Rong, Zhongjie Sun, Yanhua Zheng, Bolin Fan, Ziming Jia
The growing prevalence of hyperuricemia necessitates the urgent development of more potent treatments. This study aimed to develop, optimize, and evaluate the safety and efficacy of porcine–human recombinant uricase (PHRU) both in vitro and in vivo. The study employed gene editing of PHRU through site-directed mutagenesis, with recombinant proteins expressed in vitro utilizing Escherichia coli. The
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LARP1 knockdown inhibits cultured gastric carcinoma cell cycle progression and metastatic behavior Open Life Sci. (IF 2.2) Pub Date : 2024-01-22 Xin Liu, Wei-Ming Zhang, Nuo Meng, Lian-Jie Lin, Guo-Du Tang
This study aimed to clarify the role of la-related protein 1 (LARP1) in cell cycle progression and metastatic behavior of cultured gastric carcinoma (GC) cells. To do that, LARP1 expression was detected in clinical GC tissues and cell lines using quantitative real-time polymerase chain reaction (qRT-PCR) and western blotting. The cell viability, apoptosis, cell cycle, migration, invasion, and cell
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Fractalkine modulates pulmonary angiogenesis and tube formation by modulating CX3CR1 and growth factors in PVECs Open Life Sci. (IF 2.2) Pub Date : 2024-01-16 Jun Liao, Xianwu Yang, Jiejie Yang, Jingjing Xiao, Xuyang Liu, Yingquan Zhuo, Jiafei Yang, Huajian Gu
This study aimed to investigate effects of pulmonary fractalkine (FKN/CX3CL1) on angiogenesis and tube formation. Tube forming capability of pulmonary vascular endothelial cells (PVECs) was evaluated. CCK-8 assay was used to evaluate proliferation of PVECs. RT-PCR assay was used to determine angiogenesis specific biomarkers. Western blot was applied to identify CX3CR1, Akt, phosphorylated Akt (p-Akt)
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Constitutive and evoked release of ATP in adult mouse olfactory epithelium Open Life Sci. (IF 2.2) Pub Date : 2024-01-16 Sébastien Hayoz, Cuihong Jia, Colleen Cosgrove Hegg
In adult olfactory epithelium (OE), ATP plays a role in constant cell turnover and post-injury neuroregeneration. We previously demonstrated that constitutive and ATP-evoked ATP release are present in neonatal mouse OE and underlie continuous cell turn-over and post-injury neuroregeneration, and that activation of purinergic P2X7 receptors is involved in the evoked release. We hypothesized that both
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Investigating the association between dietary patterns and glycemic control among children and adolescents with T1DM Open Life Sci. (IF 2.2) Pub Date : 2024-01-05 Reema Tayyem, Sara Zakarneh, Ghadir Fakhri Al-Jayyousi
Nutrition plays a critical role in managing diabetes, particularly in children with type 1 diabetes mellitus (T1DM). This study aimed to investigate the dietary patterns associated with glycemic control among Jordanian children and adolescents with T1DM. A total of 107 Jordanian children and adolescents with T1DM were enrolled (53 males and 54 females) in this cross-sectional study. Data were collected
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Plasma levels of CD36 and glutathione as biomarkers for ruptured intracranial aneurysm Open Life Sci. (IF 2.2) Pub Date : 2024-01-05 Hanbin Wang, Luxuan Wang, Yunmei Liu, Weidong Men, Wanjiao Hao, Chuan Fang, Chunhui Li, Lijian Zhang
Evidence has proved that intracranial aneurysm (IA) formation and rupture might be closely related to inflammatory response and oxidative stress. Our objective was to evaluate the potential of CD36 and glutathione (GSH) as biomarkers for IA. In this study, the enzyme-linked immunosorbent assay was used to measure the plasma levels of CD36 and GSH in 30 IA patients and 30 healthy controls. Then, correlation