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SuperAgers and centenarians, dynamics of healthy ageing with cognitive resilience Mech. Ageing Dev. (IF 5.3) Pub Date : 2024-04-22 Md Ariful Islam, Ujala Sehar, Omme Fatema Sultana, Upasana Mukherjee, Malcolm Brownell, Sudhir Kshirsagar, P. Hemachandra Reddy
Graceful healthy ageing and extended longevity is the most desired goal for human race. The process of ageing is inevitable and has a profound impact on the gradual deterioration of our physiology and health since it triggers the onset of many chronic conditions like dementia, osteoporosis, diabetes, arthritis, cancer, and cardiovascular disease. However, some people who lived/live more than 100 years
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Plasma cfDNA abundance as a prognostic biomarker for higher risk of death in geriatric cardiovascular patients Mech. Ageing Dev. (IF 5.3) Pub Date : 2024-04-09 Maurizio Cardelli, Francesca Marchegiani, Pierpaolo Stripoli, Francesco Piacenza, Rina Recchioni, Mirko Di Rosa, Robertina Giacconi, Marco Malavolta, Roberta Galeazzi, Beatrice Arosio, Fiammetta Cafarelli, Francesco Spannella, Antonio Cherubini, Fabrizia Lattanzio, Fabiola Olivieri
The management of geriatric cardiovascular disease (CVD) patients with multimorbidity remains challenging and could potentially be improved by integrating clinical data with innovative prognostic biomarkers. In this context, the analysis of circulating analytes, including cell-free DNA (cfDNA), appears particularly promising. Here, we investigated circulating cfDNA (measured through the quantification
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Impact of Seipin in cholesterol mediated lipid droplet maturation; status of endoplasmic reticulum stress and lipophagy Mech. Ageing Dev. (IF 5.3) Pub Date : 2024-04-07 Tugce Demirel-Yalciner, Bengu Cetinkaya, Erdi Sozen, Nesrin Kartal Ozer
The global prevalence of nonalcoholic fatty liver disease (NAFLD) defined by the increased number of lipid droplets (LDs) in hepatocytes, have risen continuously in parallel with the obesity. LDs and related proteins are known to affect cellular metabolism and signaling. Seipin, one of the most important LD-related proteins, plays a critical role in LD biogenesis. Although the role of adipose tissue-specific
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Renal lipid accumulation and aging linked to tubular cells injury via ANGPTL4 Mech. Ageing Dev. (IF 5.3) Pub Date : 2024-04-03 Xiaojun Wang, Hung-chen Chang, Xuchao Gu, Wanlin Han, Shihang Mao, Lili Lu, Shuai Jiang, Haiyong Ding, Shisheng Han, Xinkai Qu, Zhijun Bao
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In the land of not-unhappiness: On the state-of-the-art of targeting aging and age-related diseases by biomedical research Mech. Ageing Dev. (IF 5.3) Pub Date : 2024-03-30 Eirini Klinaki, Mikolaj Ogrodnik
The concept of the Land of Not-Unhappiness refers to the potential achievement of eliminating the pathologies of the aging process. To inform of how close we are to settling in the land, we summarize and review the achievements of research on anti-aging interventions over the last hundred years with a specific focus on strategies that slow down metabolism, compensate for aging-related losses, and target
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Molecular mechanisms implicated in protein changes in the Alzheimer’s disease human hippocampus Mech. Ageing Dev. (IF 5.3) Pub Date : 2024-03-28 Hai Duc Nguyen, Woong-Ki Kim, Giang Huong Vu
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Mitochondria-targeted esculetin and metformin delay endothelial senescence by promoting fatty acid β-oxidation: Relevance in age-associated atherosclerosis Mech. Ageing Dev. (IF 5.3) Pub Date : 2024-03-28 Sriravali Pulipaka, Hridya Chempon, Gajalakshmi Singuru, Shashikanta Sahoo, Altab Shaikh, Sunita Kumari, Rajamannar Thennati, Srigiridhar Kotamraju
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Unraveling the dual role of ADAM10: Bridging the gap between cancer and Alzheimer’s disease Mech. Ageing Dev. (IF 5.3) Pub Date : 2024-03-19 Vanessa Alexandre-Silva, Marcia Regina Cominetti
An inverse association between Alzheimer’s disease (AD) and cancer has been proposed. Patients with a cancer history have a decreased risk of developing AD, and AD patients have a reduced cancer incidence, which is not seen in vascular dementia patients. Given this association, common molecular and biological mechanisms that could explain this inverse relationship have been proposed before, such as
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The effect of the demographic history on the evolution of senescence: A potential new test of the mutation accumulation theory Mech. Ageing Dev. (IF 5.3) Pub Date : 2024-03-16 Guillaume Péron
The different evolutionary theories of senescence predict different directions for the correlation between the population size and the intensity of senescence. Using simulations, I highlighted how the effect of the population size on the intensity of senescence could be reinforced by the time since populations have been large or small. I devised a mutation-selection model in which the effect of the
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The role of longevity-related genetic variant interactions as predictors of survival after 85 years of age Mech. Ageing Dev. (IF 5.3) Pub Date : 2024-03-13 Maja Šetinc, Željka Celinšćak, Luka Bočkor, Matea Zajc Petranović, Anita Stojanović Marković, Marijana Peričić Salihović, Joris Deelen, Tatjana Škarić-Jurić
Genome-wide association studies and candidate gene studies have identified several genetic variants that might play a role in achieving longevity. This study investigates interactions between pairs of those single nucleotide polymorphisms (SNPs) and their effect on survival above the age of 85 in a sample of 327 Croatian individuals. Although none of the SNPs individually showed a significant effect
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Towards personalized nicotinamide mononucleotide (NMN) supplementation: Nicotinamide adenine dinucleotide (NAD) concentration Mech. Ageing Dev. (IF 5.3) Pub Date : 2024-02-29 Ajla Hodzic Kuerec, Weilan Wang, Lin Yi, Rongsheng Tao, Zhigang Lin, Aditi Vaidya, Sohal Pendse, Sornaraja Thasma, Niranjan Andhalkar, Ganesh Avhad, Vidyadhar Kumbhar, Andrea B. Maier
Nicotinamide mononucleotide (NMN) is a precursor of nicotinamide adenine dinucleotide (NAD), which declines with age. Supplementation of NMN has been shown to improve blood NAD concentration. However, the optimal NMN dose remains unclear. This is a post-hoc analysis of a double-blinded clinical trial involving 80 generally healthy adults aged 40–65 years. The participants received a placebo or daily
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Insights into targeting cellular senescence with senolytic therapy: The journey from preclinical trials to clinical practice Mech. Ageing Dev. (IF 5.3) Pub Date : 2024-02-23 Peng Chen, Yulai Wang, Benhong Zhou
Interconnected, fundamental aging processes are central to many illnesses and diseases. Cellular senescence is a mechanism that halts the cell cycle in response to harmful stimuli. Senescent cells (SnCs) can emerge at any point in life, and their persistence, along with the numerous proteins they secrete, can negatively affect tissue function. Interventions aimed at combating persistent SnCs, which
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Common and distinct metabolomic markers related to immune aging in Western European and East African populations Mech. Ageing Dev. (IF 5.3) Pub Date : 2024-02-14 Ozlem Bulut, Godfrey S. Temba, Valerie A.C.M. Koeken, Simone J.C.F.M. Moorlag, L. Charlotte J. de Bree, Vera P. Mourits, Vesla I. Kullaya, Martin Jaeger, Cancan Qi, Niels P. Riksen, Jorge Domínguez-Andrés, Cheng-Jian Xu, Leo A.B. Joosten, Yang Li, Quirijn de Mast, Mihai G. Netea
In old age, impaired immunity causes high susceptibility to infections and cancer, higher morbidity and mortality, and poorer vaccination efficiency. Many factors, such as genetics, diet, and lifestyle, impact aging. This study aimed to investigate how immune responses change with age in healthy Dutch and Tanzanian individuals and identify common metabolites associated with an aged immune profile.
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Long-COVID-19 autonomic dysfunction: An integrated view in the framework of inflammaging Mech. Ageing Dev. (IF 5.3) Pub Date : 2024-02-13 Sergio Giunta, Chiara Giordani, Maria De Luca, Fabiola Olivieri
The recently identified syndrome known as Long COVID (LC) is characterized by a constellation of debilitating conditions that impair both physical and cognitive functions, thus reducing the quality of life and increasing the risk of developing the most common age-related diseases. These conditions are linked to the presence of symptoms of autonomic dysfunction, in association with low cortisol levels
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WDR23 mediates NRF2 proteostasis and cytoprotective capacity in the hippocampus Mech. Ageing Dev. (IF 5.3) Pub Date : 2024-02-01 Jiahui Liu, Chatrawee Duangjan, Ronald W. Irwin, Sean P. Curran
Pathogenic brain aging and neurodegenerative diseases such as Alzheimer's disease and Parkinson’s disease are characterized by chronic neuroinflammation and the accumulation of dysfunctional or misfolded proteins that lead to progressive neuronal cell death. Here we demonstrate that a murine model with global loss of the CUL4-DDB1 substrate receptor WDR23 () results in changes in multiple age-related
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The close relationship between oocyte aging and telomere shortening, and possible interventions for telomere protection Mech. Ageing Dev. (IF 5.3) Pub Date : 2024-02-01 Saffet Ozturk
As women delay childbearing due to socioeconomic reasons, understanding molecular mechanisms decreasing oocyte quantity and quality during ovarian aging becomes increasingly important. The ovary undergoes biological aging at a higher pace when compared to other organs. As is known, telomeres play crucial roles in maintaining genomic integrity, and their shortening owing to increased reactive oxygen
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Age-dependent energy metabolism and transcriptome changes in urine-derived stem cells Mech. Ageing Dev. (IF 5.3) Pub Date : 2024-01-22 Elisabete Ferreiro, Mariana Monteiro, Francisco Pereira, Cristina Barroso, Conceição Egas, Paula Macedo, Jorge Valero, Vilma A. Sardão, Paulo J. Oliveira
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Calcium transferring from ER to mitochondria via miR-129/ITPR2 axis controls cellular senescence in vitro and in vivo Mech. Ageing Dev. (IF 5.3) Pub Date : 2024-01-11 Yue Gao, Lei Xu, Yaru Li, Dandan Qi, Chaofan Wang, Changjiao Luan, Shihui Zheng, Qiu Du, Weili Liu, Guotao Lu, Weijuan Gong, Xingjie Ma
Senescent cells are known to be accumulated in aged organisms. Although the two main characteristics, cell cycle arrest (for dividing cells) and secretion of senescence-associated secretory phenotype (SASP) factors, have been well described, the lack of sufficient senescent markers and incomplete understanding of mechanisms have limited the progress of the anti-senescence field. Calcium transferred
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Novel 18-norspirostane steroidal saponins: Extending lifespan and mitigating neurodegeneration through promotion of mitophagy and mitochondrial biogenesis in Caenorhabditis elegans Mech. Ageing Dev. (IF 5.3) Pub Date : 2024-01-10 An-Guo Wu, Yuan-Yuan Yong, Chang-Long He, Ya-Ping Li, Xing-Yue Zhou, Lu Yu, Qi Chen, Cai Lan, Jian Liu, Chong-Lin Yu, Da-Lian Qin, Jian-Ming Wu, Xiao-Gang Zhou
Pharmacological strategies to delay aging and combat age-related diseases are increasingly promising. This study explores the anti-aging and therapeutic effects of two novel 18-norspirostane steroidal saponins from Maxim, namely deoxytrillenoside CA (DTCA) and epitrillenoside CA (ETCA), using (). Both DTCA and ETCA significantly extended the lifespan of wild-type N2 worms and improved various age-related
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Sleep disorders and Alzheimer’s disease pathophysiology: The role of the Glymphatic System. A scoping review Mech. Ageing Dev. (IF 5.3) Pub Date : 2023-12-30 Kyriaki Astara, Alexandros Tsimpolis, Konstantinos Kalafatakis, George D. Vavougios, Georgia Xiromerisiou, Efthimios Dardiotis, Nikos G. Christodoulou, Myrto T. Samara, Andreas S. Lappas
Background Alzheimer’s disease (AD) is highly intertwined with sleep disturbances throughout its whole natural history. Sleep consists of a major compound of the functionality of the glymphatic system, as the synchronized slow-wave activity during NREM facilitates cerebrospinal and interstitial long-distance mixing. Objective: The present study undertakes a scoping review of research on the involvement
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Moderate dietary restriction delays the onset of age-associated sarcopenia in Caenorhabditis elegans due to reduced myosin UNC-54 degradation Mech. Ageing Dev. (IF 5.3) Pub Date : 2023-12-30 Sobha Tumbapo, Adam Strudwick, Jana J. Stastna, Simon C. Harvey, Marieke J. Bloemink
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A feasibility study of the combination of intranasal insulin with oral semaglutide for cognition in older adults with metabolic syndrome at high dementia risk- Study rationale and design Mech. Ageing Dev. (IF 5.3) Pub Date : 2023-12-29 Tal Davidy, Iscka Yore, Tali Cukierman-Yaffe, Ramit Ravona-Springer, Abigail Livny, Orit H. Lesman-Segev, Yossi Azuri, Owen Carmichael, Dimitrios Kapogiannis, Henrik Zetterberg, HungMo Lin, Mary Sano, Michal Schnaider Beeri
We present the rationale and design of a double-blind placebo-controlled feasibility trial combining intranasal insulin (INI) with semaglutide, a GLP-1 receptor agonist, to improve cognition in older adults with metabolic syndrome (MetS) and mild cognitive impairment (MCI). Since both INI and dulaglutide have beneficial effects on the cerebrovascular disease (CVD), we anticipate that improved CVD will
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The cGAS-STING signaling pathway is modulated by urolithin A Mech. Ageing Dev. (IF 5.3) Pub Date : 2023-12-16 H.B. Madsen, J-H. Park, X. Chu, Y. Hou, Z. Li, L.J. Rasmussen, D.L. Croteau, V.A. Bohr, M. Akbari
During aging, general cellular processes, including autophagic clearance and immunological responses become compromised; therefore, identifying compounds that target these cellular processes is an important approach to improve our health span. The innate immune cGAS-STING pathway has emerged as an important signaling system in the organismal defense against viral and bacterial infections, inflammatory
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Relation of the Kynurenine Pathway With Normal Age: A Systematic Review Mech. Ageing Dev. (IF 5.3) Pub Date : 2023-12-05 Lieke Bakker, Kyonghwan Choe, J.P.M. Eussen Simone, Inez H.G.B. Ramakers, Daniel L.A. van den Hove, Gunter Kenis, Bart P.F. Rutten, Frans R.J. Verhey, Sebastian Köhler
Background The kynurenine pathway (KP) is gaining more attention as a common pathway involved in age-related conditions. However, which changes in the KP occur due to normal ageing is still largely unclear. The aim of this systematic review was to summarize the available evidence for associations of KP metabolites with age. Methods We used an broad search strategy and included studies up to October
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Current senolytics: Mode of action, efficacy and limitations, and their future Mech. Ageing Dev. (IF 5.3) Pub Date : 2023-11-29 Amirhossein Nayeri Rad, Johannes Grillari
Senescence is a cellular state characterized by its near-permanent halted cell cycle and distinct secretory phenotype. Although senescent cells have a variety of beneficial physiological functions, progressive accumulation of these cells due to aging or other conditions has been widely shown to provoke deleterious effects on the normal functioning of the same or higher-level biological organizations
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The skin of the naked mole-rat and its resilience against aging and cancer Mech. Ageing Dev. (IF 5.3) Pub Date : 2023-11-21 Meinhard Wlaschek, Karmveer Singh, Pallab Maity, Karin Scharffetter-Kochanek
The naked mole-rat (NMR) Heterocephalus glaber (from the Greek/latin words ἕτερος, heteros = divergent, κεφαλή, kephalē = head and glabra = hairless) was first described by Rüppell (Fig. 1) and belongs to the Hystricognath (from the Greek words ὕστριξ, hystrix = porcupine and γνάθος, gnathos = jaw) as a suborder of rodents. NMR are characterized by the highest longevity among rodents and reveal a profound
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Protective effects of apigenin on the brain transcriptome with aging Mech. Ageing Dev. (IF 5.3) Pub Date : 2023-11-24 Alyssa N. Cavalier, Zachary S. Clayton, Devin Wahl, David A. Hutton, Cali M. McEntee, Douglas R. Seals, Thomas J. LaRocca
Brain aging is associated with reduced cognitive function that increases the risk for dementia. Apigenin is a bioactive plant compound that inhibits cellular aging processes and could protect against age-related cognitive dysfunction, but its mechanisms of action in the brain have not been comprehensively studied. We characterized brain transcriptome changes in young and old mice treated with apigenin
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Piezo1 transforms mechanical stress into pro senescence signals and promotes osteoarthritis severity Mech. Ageing Dev. (IF 5.3) Pub Date : 2023-10-13 Yikai Liu, Zian Zhang, Jun Li, Bingying Chang, Qingbo Lin, Fengyu Wang, Wenzhe Wang, Haining Zhang
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Hutchinson-Gilford progeria syndrome: Cardiovascular manifestations and treatment Mech. Ageing Dev. (IF 5.3) Pub Date : 2023-10-11 Jing Lian, Linfang Du, Yang Li, Yue Yin, Lu Yu, Shengwei Wang, Heng Ma
Hutchinson-Gilford progeria syndrome (HGPS), also known as hereditary progeria syndrome, is caused by mutations in the LMNA gene and the expression of progerin, which causes accelerated aging and premature death, with most patients dying of heart failure or other cardiovascular complications in their teens. HGPS patients are able to exhibit cardiovascular phenotypes similar to physiological aging,
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The age-related characteristics in bone microarchitecture, osteoclast distribution pattern, functional and transcriptomic alterations of BMSCs in mice Mech. Ageing Dev. (IF 5.3) Pub Date : 2023-10-12 QianKun Yang, ZhiYuan Wei, XiaoYu Wei, Jie Zhang, Yong Tang, Xiang Zhou, Pan Liu, Ce Dou, Fei Luo
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Decreased oxidative stress response and oxidant detoxification of skin during aging Mech. Ageing Dev. (IF 5.3) Pub Date : 2023-10-11 Xixia Dai, Yibo Hu, Ling Jiang, Li Lei, Chuhan Fu, Songjiang Wu, Xiaolin Zhang, Lu Zhu, Fan Zhang, Jing Chen, Qinghai Zeng
Oxidative stress plays an important role in the skin aging process; however, the mechanisms are not fully elucidated. Especially the changes in various types of skin cells with aging and the key oxidative stress-related genes that play a regulatory role are not clear. In this study, single-cell RNA sequencing data and microarray transcriptome data were used to explore the changes in oxidative stress
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Serum levels of soluble suppression of tumorigenicity 2 (sST2) and heart-type fatty acid binding protein (H-FABP) independently predict in-hospital mortality in geriatric patients with COVID-19 Mech. Ageing Dev. (IF 5.3) Pub Date : 2023-10-04 Jacopo Sabbatinelli, Mirko Di Rosa, Angelica Giuliani, Marco Domenichelli, Anna Rita Bonfigli, Riccardo Sarzani, Antonio Cherubini, Roberto Antonicelli, Maurizio Burattini, Andrea Corsonello, Roberta Galeazzi, Lucia Babini, Marco Moretti, Antonio Domenico Procopio, Fabrizia Lattanzio, Fabiola Olivieri
Elevation of cardiac damage biomarkers is associated with adverse clinical outcomes and increased mortality in COVID-19 patients. This study assessed the association of admission serum levels of sST2 and H-FABP with in-hospital mortality in 191 geriatric patients (median age 86 yrs., IQR 82–91 yrs.) with COVID-19 and available measures of hs-cTnT and NT-proBNP at admission. Cox proportional hazards
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Exploring the interplay between metabolomics and genetics in Parkinson's disease: Insights from ongoing research and future avenues Mech. Ageing Dev. (IF 5.3) Pub Date : 2023-09-23 Cíntia Barros Santos-Rebouças, Juliana Cordovil Cotrin, Gilson Costa dos Santos Junior
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Mitochondrial microRNAs (mitomiRs) in human ageing and diseases Mech. Ageing Dev. (IF 5.3) Pub Date : 2023-09-12 Maria Gaitanou
Abstract not available
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The influence of inflammation and frailty in the aging continuum Mech. Ageing Dev. (IF 5.3) Pub Date : 2023-09-08 Beatrice Arosio, Evelyn Ferri, Daniela Mari, Eleonora Tobaldini, Giovanni Vitale, Nicola Montano
Inflammaging is a low-grade inflammatory state that can be considered an adaptive process aimed at stimulating appropriate anti-inflammatory response. Frailty is determined by the accumulation of molecular and cellular defects accumulated throughout life; therefore, an appropriate frailty computation could be a valuable tool for measuring biological age. This study aims to analyse the association between
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Cardiac iron metabolism during aging – Role of inflammation and proteolysis Mech. Ageing Dev. (IF 5.3) Pub Date : 2023-09-09 Sophia Walter, Christina Mertens, Martina U. Muckenthaler, Christiane Ott
Iron is the most abundant trace element in the human body. Since iron can switch between its 2-valent and 3-valent form it is essential in various physiological processes such as energy production, proliferation or DNA synthesis. Especially high metabolic organs such as the heart rely on iron-associated iron-sulfur and heme proteins. However, due to switches in iron oxidation state, iron overload exhibits
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Lack of activity of the mitochondrial large-conductance calcium-regulated potassium channels in senescent vascular smooth muscle cells. Mech. Ageing Dev. (IF 5.3) Pub Date : 2023-09-07 Agata Głuchowska, Barbara Kalenik, Bogusz Kulawiak, Antoni Wrzosek, Adam Szewczyk, Piotr Bednarczyk, Grażyna Mosieniak
A limited number of studies have shown functional changes in mitochondrial ion channels in aging and senescent cells. We have identified, for the first time, mitochondrial large-conductance calcium-activated regulated potassium channels in human smooth muscle mitochondria. This channel, with a conductance of 273 pS, was regulated by calcium ions and membrane potential. Additionally, it was activated
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The link between obesity and aging - insights into cardiac energy metabolism Mech. Ageing Dev. (IF 5.3) Pub Date : 2023-09-07 Patricia Owesny, Tilman Grune
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Assessment and risk prediction of frailty using texture-based muscle ultrasound image analysis and machine learning techniques Mech. Ageing Dev. (IF 5.3) Pub Date : 2023-09-04 Rebeca Mirón-Mombiela, Silvia Ruiz-España, David Moratal, Consuelo Borrás
The purpose of this study was to evaluate texture-based muscle ultrasound image analysis for the assessment and risk prediction of frailty phenotype. This retrospective study of prospectively acquired data included 101 participants who underwent ultrasound scanning of the anterior thigh. Participants were subdivided according to frailty phenotype and were followed up for two years. Primary and secondary
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Aging-related decrease of histone methyltransferase SUV39H1 in adipose-derived stem cells enhanced SASP Mech. Ageing Dev. (IF 5.3) Pub Date : 2023-09-02 Ruoyu Li, Yungshan Teng, Yuqing Guo, Jianhan Ren, Runze Li, Haotian Luo, Danying Chen, Zhicai Feng, Zheng Fu, Xuenong Zou, Weicai Wang, Chen Zhou
Aging-related diseases are closely associated with the state of inflammation, which is known as “inflammaging.” Senescent cells are metabolically active, as exemplified by the secretion of inflammatory cytokines, chemokines, and growth factors, which is termed the senescence-associated secretory phenotype (SASP). Epigenetic regulation, especially the structural regulation of chromatin, is closely linked
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Endoplasmic reticulum stress and alterations of peroxiredoxins in aged hearts Mech. Ageing Dev. (IF 5.3) Pub Date : 2023-09-01 Qun Chen, Jeremy Thompson, Ying Hu, Edward J. Lesnefsky
Aging-related cardiovascular disease is influenced by multiple factors, with oxidative stress being a key contributor. Aging-induced endoplasmic reticulum (ER) stress exacerbates oxidative stress by impairing mitochondrial function. Furthermore, a decline in antioxidants, including peroxiredoxins (PRDXs), augments the oxidative stress during aging. To explore if ER stress leads to PRDX degradation
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Lipids and the hallmarks of ageing: From pathology to interventions Mech. Ageing Dev. (IF 5.3) Pub Date : 2023-08-29 Rohit Sharma, Bhawna Diwan
Lipids are critical structural and functional architects of cellular homeostasis. Change in systemic lipid profile is a clinical indicator of underlying metabolic pathologies, and emerging evidence is now defining novel roles of lipids in modulating organismal ageing. Characteristic alterations in lipid metabolism correlate with age, and impaired systemic lipid profile can also accelerate the development
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Impact of air pollution on cardiovascular aging Mech. Ageing Dev. (IF 5.3) Pub Date : 2023-08-21 Marin Kuntic, Ivana Kuntic, Omar Hahad, Jos Lelieveld, Thomas Münzel, Andreas Daiber
The world population is aging rapidly, and by some estimates, the number of people older than 60 will double in the next 30 years. With the increase in life expectancy, adverse effects of environmental exposures start playing a more prominent role in human health. Air pollution is now widely considered the most detrimental of all environmental risk factors, with some studies estimating that almost
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Reprogramming iPSCs to study age-related diseases: Models, therapeutics, and clinical trials Mech. Ageing Dev. (IF 5.3) Pub Date : 2023-08-12 Filipa Esteves, David Brito, Ana Teresa Rajado, Nádia Silva, Joana Apolónio, Vânia Palma Roberto, Inês Araújo, Clévio Nóbrega, Pedro Castelo-Branco, José Bragança
The unprecedented rise in life expectancy observed in the last decades is leading to a global increase in the ageing population, and age-associated diseases became an increasing societal, economic, and medical burden. This has boosted major efforts in the scientific and medical research communities to develop and improve therapies to delay ageing and age-associated functional decline and diseases,
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Targeting senescence and inflammation in chronic destructive TNF-driven joint pathology Mech. Ageing Dev. (IF 5.3) Pub Date : 2023-08-07 Nikolaos I. Vlachogiannis, Konstantinos Evangelou, Lydia Ntari, Christoforos Nikolaou, Maria C. Denis, Niki Karagianni, Dimitris Veroutis, Vassilis Gorgoulis, George Kollias, Petros P. Sfikakis
We had shown that administration of the senolytic Dasatinib abolishes arthritis in the human TNF transgenic mouse model of chronic destructive arthritis when given in combination with a sub-therapeutic dose of the anti-TNF mAb Infliximab (1 mg/kg). Herein, we found that while the number of senescent chondrocytes (GL13+/Ki67-), assessed according to guideline algorithmic approaches, was not affected
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Role of cytokines and reactive oxygen species in brain aging Mech. Ageing Dev. (IF 5.3) Pub Date : 2023-08-03 Sheba M.J. MohanKumar, Abarna Murugan, Arunkumar Palaniyappan, Puliyur S. MohanKumar
Aging is a complex process that produces profound effects on the brain. Although a number of external factors can promote the initiation and progression of brain aging, peripheral and central changes in the immune cells with time, also play an important role. Immunosenescence, which is an age-associated decline in immune function and Inflammaging, a low-grade inflammatory state in the aging brain contribute
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RNA-binding proteins in cellular senescence Mech. Ageing Dev. (IF 5.3) Pub Date : 2023-07-13
Cellular senescence is a state of irreversible cell cycle arrest that is triggered and controlled by various external and/or internal factors. Among them, the regulation of senescence-associated genes is an important molecular event that plays a role in senescence. The regulation of gene expression can be achieved by various types of modulating mechanisms, and RNA-binding proteins (RBPs) are commonly
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Ageing-associated phenotypes in mice Mech. Ageing Dev. (IF 5.3) Pub Date : 2023-07-14 Kan Xie, Dan Ehninger
Ageing is a continuous process in life featuring progressive damage accumulation that leads to physiological decline, functional deterioration and ultimately death of an organism. Based on the relatively close anatomical and physiological similarity to humans, the mouse has been proven as a valuable model organism in ageing research over the last decades. In this review, we survey methods and tools
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Preserving the discreteness of deficits during coding leads to a lower frailty index in individuals living in long-term care Mech. Ageing Dev. (IF 5.3) Pub Date : 2023-07-13 Brian Greeley, Hilary Low, Ronald Kelly, Robert McDermid, Xiaowei Song
This study assesses two coding approaches on the frailty index (FI). Two FI were calculated using 43 variables from 29,758 older adults (84.6 ± 8 years old; 64 % female) in long-term care. Scores were coded as 0, 0.5, or 1 regardless of the number of levels (grouped), or preserved (e.g., a 4 level variable was coded as 0, 0.33, 0.67, or 1; discrete). Grouped and discrete FI were compared with each
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New frontiers in ageing and longevity: Sex and gender medicine Mech. Ageing Dev. (IF 5.3) Pub Date : 2023-07-05 Carmela Rita Balistreri
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PRENATAL EXPOSURE TO CB2 RECEPTORS AGONIST DIFFERENTIALLY IMPACTS MALE AND FEMALE GERM CELLS VIA HISTONE MODIFICATION Mech. Ageing Dev. (IF 5.3) Pub Date : 2023-06-28 Alice Zucchi, Elisa Innocenzi, Angelo Onorato, Susanna Dolci, Ambra Colopi, Carmela Rita Balistreri, Paola Grimaldi
Cannabis use during pregnancy is increasing in the last few years potentially because of decreased perception of the risk of harm. Regardless, recent evidence demonstrated that prenatal cannabis exposure is associated with adverse outcomes. To date there is limited evidence of the impact of cannabis exposure during pregnancy on the reproductive health of the offspring. The biological effects of cannabis
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Improving intestinal inflammaging to delay aging? A new perspective Mech. Ageing Dev. (IF 5.3) Pub Date : 2023-06-30 Lan Zhang, Junbin Yan, Chi Zhang, Shuyan Feng, Zheli Zhan, Yang Bao, Shuo Zhang, Guanqun Chao
Greying population is becoming an increasingly critical issue for social development. In advanced aging context, organismal multiple tissues and organs experience a progressive deterioration, initially presenting with functional decline, followed by structural disruption and eventually organ failure. The aging of the gut is one of the key links. Decreased gut function leads to reduced nutrient absorption
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What do we mean by “aging”? Questions and perspectives revealed by studies in Drosophila Mech. Ageing Dev. (IF 5.3) Pub Date : 2023-06-23 Andrew P.K. Wodrich, Andrew W. Scott, Edward Giniger
What is the nature of aging, and how best can we study it? Here, using a series of questions that highlight differing perspectives about the nature of aging, we ask how data from Drosophila melanogaster at the organismal, tissue, cellular, and molecular levels shed light on the complex interactions among the phenotypes associated with aging. Should aging be viewed as an individual’s increasing probability
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Understanding the roles and regulation of mitochondrial microRNAs (MitomiRs) in neurodegenerative diseases: Current status and advances Mech. Ageing Dev. (IF 5.3) Pub Date : 2023-06-15 Bhaskar Jyoti Saikia, Juhi Bhardwaj, Sangita Paul, Srishti Sharma, Anindita Neog, Swaraj Ranjan Paul, Binukumar BK
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DYRK1B inhibition exerts senolytic effects on endothelial cells and rescues endothelial dysfunctions Mech. Ageing Dev. (IF 5.3) Pub Date : 2023-06-08 Francesca M. Pramotton, Asra Abukar, Chantelle Hudson, James Dunbar, Andrew Potterton, Simone Tonnicchia, Andrea Taddei, Edoardo Mazza, Costanza Giampietro
Aging is the major risk factor for chronic disease development. Cellular senescence is a key mechanism that triggers or contributes to age-related phenotypes and pathologies. The endothelium, a single layer of cells lining the inner surface of a blood vessel, is a critical interface between blood and all tissues. Many studies report a link between endothelial cell senescence, inflammation, and diabetic
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Aging – What it is and how to measure it Mech. Ageing Dev. (IF 5.3) Pub Date : 2023-06-09 Maryam Keshavarz, Kan Xie, Daniele Bano, Dan Ehninger
The current understanding of the biology of aging is largely based on research aimed at identifying factors that influence lifespan. However, lifespan as a sole proxy measure of aging has limitations because it can be influenced by specific pathologies (not generalized physiological deterioration in old age). Hence, there is a great need to discuss and design experimental approaches that are well-suited
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Age-associated anatomical and physiological alterations in Caenorhabditis elegans Mech. Ageing Dev. (IF 5.3) Pub Date : 2023-06-01 Emmanuel Spanoudakis, Nektarios Tavernarakis
Since its introduction by Sydney Brenner, Caenorhabditis elegans has become a widely studied organism. Given its highly significant properties, including transparency, short lifespan, self-fertilization, high reproductive yield and ease in manipulation and genetic modifications, the nematode has contributed to the elucidation of several fundamental aspects of biology, such as development and ageing
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Involvement of miRNA on epigenetics landscape of Parkinson's disease: From pathogenesis to therapeutics Mech. Ageing Dev. (IF 5.3) Pub Date : 2023-05-31 Sai Nikhil Uppala, Kamatham Pushpa Tryphena, Padmashri Naren, Saurabh Srivastava, Shashi Bala Singh, Dharmendra Kumar Khatri