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Response to Hoffman M et al., Risk Factors for Surgical Site Complications After Outpatient Lumbar Spine Surgery (doi: 10.1089/2023.040). Surg. Infect. (IF 2.0) Pub Date : 2023-11-29 Caining Wen,Yuanmin Zhang,Yuge Zhang
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Late and Persistent Symptoms Suggestive of Surgical Site Infections After Cesarean Section: Results from a Prospective Cohort Study in Rural Rwanda. Surg. Infect. (IF 2.0) Pub Date : 2023-11-29 Joselyne Mukantwari,Jean de Dieu Gatete,Anne Niyigena,Barnabas Tobi Alayande,Theoneste Nkurunziza,Christian Mazimpaka,Adeline A Boatin,Fredrick Kateera,Bethany Hedt-Gauthier,Robert Riviello
Background: Women in low-resource settings will likely develop late surgical site infections (SSIs), diagnosed after post-operative day (POD) 10. We measured SSI prevalence and predictors of late and persistent SSIs-suggestive symptoms among women who delivered via cesarean section (c-section). Patients and Methods: Women who underwent c-sections at Kirehe District Hospital (KDH) between September
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A Pathway for Increased Diversity, Equity, and Inclusion in the Surgical Infection Society. Surg. Infect. (IF 2.0) Pub Date : 2023-11-29 Vanita Ahuja,Mayur Narayan,Sabrina E Sanchez,Elinore Kaufman,Vanessa Ho
Background: With the rise of diversity, equity, and inclusion (DEI) efforts across medicine, the Surgical Infection Society (SIS) leadership undertook a several-year mission to evaluate DEI issues within the SIS, through the formation of a DEI Ad Hoc Committee to guide the application of best practices. The purpose of this article is to describe the work of the DEI committee since its inception, as
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Quality of Life After Intensive Care Unit Admittance for Necrotizing Soft Tissue Infections Is Deemed Acceptable for Patients. Surg. Infect. (IF 2.0) Pub Date : 2023-11-29 Femke Nawijn,Monika C Kerckhoffs,Falco Hietbrink
Background: Because mortality and amputation rates are declining for necrotizing soft tissue infections (NSTIs), this study aimed to assesses the self-reported one-year quality of life (QoL) of severely ill patients with NSTI who survived beyond the intensive care unit (ICU). Patients and Methods: A retrospective cohort study of patients with NSTI admitted to the ICU between 2010 and 2019 was conducted
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Role of Pre-Operative Nutrition Status on Surgical Site Infection After Posterior Lumbar Interbody Fusion: A Retrospective Study. Surg. Infect. (IF 2.0) Pub Date : 2023-11-28 Yi-Fan Yang,Jun-Cheng Yu,Zhen Xiao,Yi-Jun Kang,Bin Zhou
Background: A retrospective case-control study to determine the role of pre-operative systemic and local nutritional factors on patients developing a surgical site infection (SSI) after posterior lumbar interbody fusion (PLIF). Surgical site infection after PLIF remains a substantial cause of morbidity. The literature demonstrates the prognosis of surgical patients is associated with pre-operative
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Letter to the Editor: Submandibular Gland Tuberculosis Is Mimicking Submandibular Gland Tumor. Surg. Infect. (IF 2.0) Pub Date : 2023-11-28 Jiaxin Liu Yongmao Huang,Ying Si
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Predicting Acute Appendicitis in Pregnant Patients Using the Neutrophil-to-Lymphocyte Ratio: A Meta-Analysis. Surg. Infect. (IF 2.0) Pub Date : 2023-11-27 Yangchong Feng,Chongxiu Miao,Yahui Zhao
Background: To determine whether the neutrophil-to-lymphocyte ratio (NLR) can serve as a predictive indicator for acute appendicitis among pregnant females. Patients and Methods: A comprehensive search was conducted across multiple databases including PubMed, Embase, and Web of Science seeking to gather pertinent research on the NLR concerning pregnant individuals either suspected of or diagnosed with
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Burden of Social and Behavioral Determinants of Health on Infectious Complications in Emergency General Surgery. Surg. Infect. (IF 2.0) Pub Date : 2023-11-27 Emanuele Lagazzi,Jefferson A Proaño-Zamudio,Dias Argandykov,Wardah Rafaqat,May Abiad,Anne-Sophie Romijn,Elaine P X van Ee,George C Velmahos,Haytham M A Kaafarani,John O Hwabejire
Background: Infectious complications lead to worse post-operative outcomes and are used to compare hospital performance in pay-for-performance programs. However, the impact of social and behavioral determinants of health on infectious complication rates after emergency general surgery (EGS) remains unclear. Patients and Methods: All patients undergoing EGS in the 2019 Nationwide Readmissions Database
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Is There a Community Microbial Community? A Comparison of Pathogens Between Two Hospital Surgical Intensive Care Units in a Single City. Surg. Infect. (IF 2.0) Pub Date : 2023-11-27 Mikayla Moody,Robert Sawyer
Background: Nosocomial and health-care-associated infections drive increased healthcare costs and negatively affect patient outcomes. The human microbiome has been heavily explored in recent years with incomplete data regarding hospital-specific and community-specific microbial communities. Although bacterial species differ between intensive care units in the same hospital, it is unclear if they differ
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Identification of Risk Factors for Intra-Abdominal Candidiasis. Surg. Infect. (IF 2.0) Pub Date : 2023-11-23 Kelsey Habighorst,James M Sanders,Sara A Hennessy,Kristina Goff,Bingchun Wan,Meagan Johns
Background: Intra-abdominal candidiasis (IAC) is associated with substantial morbidity and mortality in hospitalized patients. Identifying high-risk populations may facilitate early and selective directed therapy in appropriate patients and avoid unwarranted treatment and any associated adverse effects in those who are low risk. Patients and Methods: This retrospective, case-control study included
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Are There Racial Differences in the Rate of Surgical Site Infection Based on Surgical Subspecialty? Surg. Infect. (IF 2.0) Pub Date : 2023-11-21 Matthew Welter,Kent Grosh,Joslyn Jose,Sarah Khalil,Afnan Muharraq,Alain Elian,Gitonga Munene,Robert Sawyer,Saad Shebrain
Background: Surgical site infection (SSI) is a common, morbid post-operative complication. We hypothesized the presence of racial differences in SSI rates, comparing black/African American (BAA) to white non-Hispanic (WNH) patients. Patients and Methods: Using the American College of Surgeons National Surgical Quality Improvement Program (ACS-NSQIP) database (2017), BAA and WNH surgery patients across
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Neutrophil Extracellular Traps Are Induced by Coronavirus 2019 Disease-Positive Patient Plasma and Persist Longitudinally: A Possible Link to Endothelial Dysfunction as Measured By Syndecan-1. Surg. Infect. (IF 2.0) Pub Date : 2023-11-21 Edward J Kelly,Mary A Oliver,Bonnie C Carney,Sindhura Kolachana,Lauren T Moffatt,Jeffrey W Shupp
Background: Neutrophil extracellular trap (NET) formation is a mechanism that neutrophils possess to respond to host infection or inflammation. However, dysregulation of NETosis has been implicated in many disease processes. Although the exact mechanisms of their involvement remain largely unknown, this study aimed to elucidate NET formation over the time course of coronavirus disease 2019 (COVID-19)
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Letter to the Editor: Fulminant Necrotizing Enterocolitis: Beware of Clostridia. Surg. Infect. (IF 2.0) Pub Date : 2023-11-10 Mohamed Zouari,Manar Hbaieb,Manel Belhajmansour,Emna Krichen,Amel Ben Hamad,Mahdi Ben Dhaou,Riadh Mhiri
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Antiseptic Skin Agents to Prevent Surgical Site Infection After Clean Implant Surgery: Subgroup Analysis of the NEWSkin Prep Trial. Surg. Infect. (IF 2.0) Pub Date : 2023-11-10 Stephen Smith,Ibrahim Abuhassanian,John Attia,Rosemary Carroll,Natalie Lott,Jacob Hampton,Jon Gani
Background: There remains debate as to the ideal skin preparation agent to prevent surgical site infection (SSI) after clean implant surgery. This study is a subgroup analysis of all patients undergoing implant surgery in the NEWSkin prep trial. Patients and Methods: The NEWSkin prep trial is a randomized clinical trial (RCT; n = 3300) comparing the three antiseptic skin preparation agents commonly
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Ludwig's Angina: Higher Incidence and Worse Outcomes Associated With the Onset of the Coronavirus Disease 2019 Pandemic. Surg. Infect. (IF 2.0) Pub Date : 2023-11-10 Melissa Canas,Ricardo Fonseca,Alejandro De Filippis,Leonardo Diaz,Hussain Afzal,Aaron Day,Jennifer Leonard,Kelly Bochicchio,Grant V Bochicchio,Mark Hoofnagle
Background: Ludwig's angina (LA) is a diffuse cellulitis of the submandibular space and adjacent tissues. During the coronavirus disease 2019 (COVID-19) pandemic, odontogenic treatments were often delayed because of the implementation of safety measures to avoid the spread of the virus. We hypothesized that delayed odontogenic treatments associated with the onset of the COVID-19 pandemic would be associated
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Diagnostic Accuracy of Procalcitonin for Infection After Adult Liver Transplantation: A Meta-Analysis and Systematic Review. Surg. Infect. (IF 2.0) Pub Date : 2023-11-10 Pan You,Rong-Yue Gao,Yu-Zhen Han,Xiao-Ke Zhang,Wen-Xiong Li,Li-Feng Huang
Background: Post-operative infection remains a major cause of morbidity and mortality in adults early after liver transplantation (LT). Procalcitonin (PCT) may be a good test method for early diagnosis of post-operative infection and determining its severity. This study was performed to assess the diagnostic accuracy of PCT as a biomarker for infection after LT. Patients and Methods: A meta-analysis
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Efficacy of Body Wash and Povidone-Iodine in Skin Preparation in Reducing Surgical Site Infections After Hypospadias Repair Among Adolescents: A Prospective Cohort Study With Retrospective Controls. Surg. Infect. (IF 2.0) Pub Date : 2023-11-10 Zi-Han Ye,Chong Wang,Zhi-Cheng Zhang,Hong-Song Chen,Xiao Wang,Yan-Xi Wang,Xing Liu,Guang-Hui Wei
Background: Surgical site infections (SSIs) that occur after hypospadias repair frequently result in incision healing complications, especially during puberty. This study aimed to evaluate the efficacy of twice-daily pre-operative skin preparation using body wash and povidone-iodine within 48 hours before hypospadias repair with regard to infection rates in adolescents. Patients and Methods: Prospective
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Response to Zhu K et al., Efficacy of Antibiotic Cement in Preserving Endoplants After Infection With Plate Exposure (DOI: 10.1089/sur.2022.382). Surg. Infect. (IF 2.0) Pub Date : 2023-11-10 Jingzhi Wang,Caining Wen,Yuanmin Zhang
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Letter to the Editor: Necrotizing Enterocolitis: An Uncommon Cause of Neonatal Gastric Perforation. Surg. Infect. (IF 2.0) Pub Date : 2023-11-10 Mohamed Zouari,Emna Krichen,Manel Belhajmansour,Amel Ben Hamad,Souad Meddeb,Mahdi Ben Dhaou,Riadh Mhiri
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Letter to the Editor: Laparoscopic Pediatric Inguinal Hernia Repair Does Not Necessarily Require Prophylactic Antibiotic Agents. Surg. Infect. (IF 2.0) Pub Date : 2023-11-01 Yuki Muta,Akio Odaka,Seiichiro Inoue,Yuta Takeuchi,Yoshifumi Beck
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Sirt3 Deletion Increases Inflammation and Mortality in Polymicrobial Sepsis. Surg. Infect. (IF 2.0) Pub Date : 2023-11-01 Hanna E Labiner,Kelli M Sas,Joseph A Baur,Carrie A Sims
Background: Sirtuin 3 (SIRT3) is a nicotinamide adenine dinucleotide (NAD)-dependent deacetylase that confers resilience to cellular stress by promoting mitochondrial activity. Mitochondrial dysfunction is a major driver of inflammation during sepsis. We hypothesize that Sirt3 expression improves survival in polymicrobial sepsis by mitigating the inflammatory response. Materials and Methods: Sirt3
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Missing Narrative: Examining the Impact of Disability on Post-Operative Infectious Complications. Surg. Infect. (IF 2.0) Pub Date : 2023-11-01 Wardah Rafaqat,Emanuele Lagazzi,Jefferson A Proaño-Zamudio,Dias Argandykov,May Abiad,Angela Renne,Anne-Sophie C Romijn,Elaine P X Van Ee,John O Hwabejire,George C Velmahos,Jonathan J Parks,Haytham M A Kaafarani,Casey M Luckhurst,Michael P DeWane
Background: More than 20% of the population in the United States suffers from a disability, yet the impact of disability on post-operative outcomes remains understudied. This analysis aims to characterize post-operative infectious complications in patients with disability. Patients and Methods: This was a retrospective review of the National Readmission Database (2019) among patients undergoing common
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Impact of Prophylactic Antibiotic Selection on the Prevention and Bacterial Flora of Surgical Site Infections After Colorectal Surgery. Surg. Infect. (IF 2.0) Pub Date : 2023-11-01 Marie Abdallah,Subin Sunny,Edwin Jimenez,Subhan Ata,Jennifer Lee,Briana Episcopia,Mary Fornek,Valery Roudnitsky,John Quale
Background: Deep incisional and organ/space surgical site infections (SSIs) after colorectal surgery are associated with adverse outcomes. Multiple antibiotic regimens are recommended for peri-operative prophylaxis, with no particular regimen preferred over another. We compared the prophylaxis regimens used in patients with and without SSIs, and the impact of regimens on the flora involved in SSIs
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Analysis of Vacuum-Assisted Closure-Assisted Antibiotic Irrigation in Treatment of Severe Neurosurgical Central Nervous System Infections. Surg. Infect. (IF 2.0) Pub Date : 2023-11-01 Huaqing Wang,Shengnan Sun,Guanghui Wang,Qibing Huang,Zeli Zhang
Objective: Severe neurosurgical central nervous system infections (sNCNSIs) are among the most serious complications of neurosurgical disease. Conventional methods have shown a poor prognosis. This study aims to analyze the clinical characteristics of vacuum-assisted closure (VAC) in sNCNSIs with the help of antibiotic irrigation treatment. Patients and Methods: A retrospective study was performed
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Serum Interleukin-6 as a Biomarker for Early Prediction of Post-Operative Infectious Complications After Elective Pancreatectomy. Surg. Infect. (IF 2.0) Pub Date : 2023-10-31 Guochao Zhao,Jing Zhu,Chenye Shi,Dansong Wang,Wenchuan Wu,Tiantao Kuang,Wei Guo,Wenhui Lou
Background: To investigate whether interleukin (IL)-6 could predict the post-operative complications of elective pancreatectomy early. Patients and Methods: Overall, 122 patients who underwent elective pancreatectomy from June 2020 to May 2021 in our hospital were enrolled. Interleukin-6 was measured on the day before and at six hours after surgery, and on post-operative day one, three, and five. The
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Surgical Interventions in Coronavirus Disease 2019 Pleural and Pulmonary Complications: A Case Series of the Tertiary Thoracic Surgery Center Experience. Surg. Infect. (IF 2.0) Pub Date : 2023-10-31 Mojtaba Mokhber Dezfuli,Azizollah Abbasi Dezfuli,Fariba Ghorbani,Mahshad Razaghi,Salman Soleimani,Moein Daneshmand,Ali Sheikhy,Kambiz Sheikhy
Background: In most cases of pulmonary or pleural post-coronavirus disease 2019 (COVID-19) complications, surgical interventions are performed to treat these complications, but the method of the surgery and its outcome in these patients is not clearly defined. We present 40 patients with pulmonary and pleural complications after COVID-19 who required surgical intervention. Patients and Methods: In
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Anemia Recovery After Lung Contusion, Hemorrhagic Shock, and Chronic Stress Is Gender-Specific in a Rat Model. Surg. Infect. (IF 2.0) Pub Date : 2023-10-30 Gwendolyn S Gillies,Jennifer A Munley,Lauren S Kelly,Erick E Pons,Kolenkode B Kannan,Letitia E Bible,Philip A Efron,Alicia M Mohr
Background: Severe trauma and hemorrhagic shock lead to persistent anemia. Although biologic gender is known to modulate inflammatory responses after critical illness, the impact of gender on anemia recovery after injury remains unknown. The aim of this study was to identify gender-specific differences in anemia recovery after critical illness. Materials and Methods: Male and proestrus female Sprague-Dawley
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Risk Factors for Post-Operative Multi-Drug-Resistant Organism Bacterial Infection in Patients With Stanford Acute Type A Aortic Dissection. Surg. Infect. (IF 2.0) Pub Date : 2023-10-27 Jing Liang,Xianzhi Cheng,Jingyu Shao,Siqing Wang,Chao Yang
Background: To explore the risk factors for multi-drug-resistant organism (MDRO) infection in patients with Stanford acute type A aortic dissection (ATAAD). We conducted a retrospective cohort study using the data of post-operative patients with ATAAD in our hospital. Patients and Methods: This study included 82 post-operative patients with ATAAD in the past decade. They were divided into a MDRO group
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Wound Infection After Ileostomy Closure: An Interim Analysis of a Prospective Randomized Study Comparing Primary Versus Circumferential Subcuticular Closure Techniques. Surg. Infect. (IF 2.0) Pub Date : 2023-10-19 Sumesh Kaistha,Rajesh Panwar,Sujoy Pal,Nihar Ranjan Dash,Peush Sahni,Tushar Kanti Chattopadhyay
Background: Circumferential subcuticular wound approximation (CSWA) of round shaped skin wounds after ileostomy take down is believed to lower the rates of surgical site infection (SSI). We performed this randomized trial to compare the rates of SSI and other short-term outcomes among primary linear skin closure (PC) and CSWA groups of patients. Patients and Methods: All patients undergoing ileostomy
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A Self-Sustaining Antibiotic Prophylaxis Program to Reduce Surgical Site Infections. Surg. Infect. (IF 2.0) Pub Date : 2023-10-13 Jesse A Codner,Elissa A Falconer,Eli Mlaver,Ronnie H Zeidan,Jyotirmay Sharma,Grant C Lynde
Background: Our multi-institutional healthcare system had a higher-than-expected surgical site infection (SSI) rate. We aimed to improve our peri-operative antibiotic administration process. Gap analysis identified three opportunities for process improvement: standardized antibiotic selection, standardized second-line antibiotic agents for patients with allergies, and feedback regarding antibiotic
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Pharmacokinetic and Pharmacodynamic Considerations of Novel Antibiotic Agents for Pediatric Infections: A Narrative Review. Surg. Infect. (IF 2.0) Pub Date : 2023-10-13 Mojtaba Shafiekhani,Seyed Amirreza Fatemi,Pouria Hosseini,Fatemeh Marhemati,Soniya Mohammadi,Fatemeh Sharifi,Ali Moorkani Kurde Esfahani Pour,Fatemeh Sadeghi Habibabad,Negin Saad Abadi,Eslam Shorafa,Soha Azadi
Background: Currently, the escalation of microbial resistance poses a significant global challenge. Children are more susceptible to develop infections and therefore are prescribed antibiotics more frequently. The overuse and misuse of antibiotics in pediatric patients can play a considerable role in developing microbial resistance. Accordingly, many policies, including research into new antibiotic
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Effect of Pre-Operative Low Serum Pre-Albumin on Surgical Site Infection in Post-Surgery Subjects: A Systematic Review and Meta-Analysis. Surg. Infect. (IF 2.0) Pub Date : 2023-10-13 Fei Zhang,Letian Huang,MingLin Li,Ziwei Quan,Yifei Wang,Hanyong Luo,Jiye Liu,Jiahe Wang
Background: The correlation between pre-operative serum pre-albumin and surgical site infection (SSI) has been the focus of many studies. However, existing literature presents conflicting evidence on this association. Therefore, this meta-analysis was conducted to determine the significance of low serum pre-albumin as a prognostic factor SSI, and to assess the potential utility of pre-albumin in predicting
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Characterizing the Crosstalk Between Programmed Cell Death Pathways in Cytokine Storm With an Agent-Based Model. Surg. Infect. (IF 2.0) Pub Date : 2023-10-12 Solomon Feuerwerker,R Chase Cockrell,Gary An
Background: There is increasing recognition of extensive crosstalk between programmed cell death pathways (PCDPs), such as apoptosis, pyroptosis, and necroptosis, resulting in a highly redundant system responsive to a breadth of potential pathogens. However, because pyroptosis and necroptosis propagate inflammation, these redundancies also present challenges for therapeutic control of dysregulated
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Efficacy of Polyhexamethylene Biguanide in Reducing Post-Operative Infections: A Systematic Review and Meta-Analysis. Surg. Infect. (IF 2.0) Pub Date : 2023-10-01 Gianluca Castiello,Giuseppe Caravella,Greta Ghizzardi,Gianluca Conte,Arianna Magon,Tiziana Fiorini,Laurenzia Ferraris,Simona Devecchi,Veronica Calorenne,Andreea Alina Andronache,Antonio Saracino,Rosario Caruso
Background: Post-operative infections are a substantial cause of morbidity and mortality worldwide. Polyhexamethylene biguanide (PHMB) is an antimicrobial agent that has been used in various surgical settings to prevent infections. However, the literature on its efficacy in reducing post-operative infections remains unclear. Materials and Methods: We conducted a systematic review and meta-analysis
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Temperature-Neutrophils-Multiple Organ Failure Grading as a Prognostic Indicator in Fournier Gangrene. Surg. Infect. (IF 2.0) Pub Date : 2023-09-28 Deniz Tazeoglu,Sami Benli,Tahsin Colak
Background: Severity scoring systems are used widely to predict prognosis in managing various diseases and to tailor the treatment of patients in a personalized way, not in a general concept, by making a risk assessment. This study examines the importance of the Temperature-Neutrophils-Multiple Organ Failure (TNM) scoring system, a new scoring system, in evaluating the prognosis in patients with Fournier
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Defining the Optimal Antibiotic Duration in Necrotizing Skin and Soft Tissue Infections: Clinical Experience from a Quaternary Referral Center. Surg. Infect. (IF 2.0) Pub Date : 2023-09-26 Dara L Horn,Jeannie D Chan,Kevin Li,Eileen M Bulger,John B Lynch,Bryce R H Robinson,Chloe Bryson-Cahn
Background: Early initiation of broad-spectrum antibiotic agents is a cornerstone of the care of necrotizing skin and soft tissue infections (NSTI). However, the optimal duration of antibiotic agents is unclear. We sought to characterize antibiotic prescribing patterns for patients with NSTI, as well as associated complications. Patients and Methods: Using an NSTI registry, we characterized antibiotic
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Differences Between Patients With Diabetes Mellitus and Obese Patients in Occurrence of Peri-Prosthetic Joint Infection: A Systemic Review and Meta-Analysis. Surg. Infect. (IF 2.0) Pub Date : 2023-09-19 Wen-Pei Chang,Yu-Xuan Peng
Background: To understand the differences between patients with diabetes mellitus and obese patients with respect to the occurrence of peri-prosthetic joint infection (PJI) after lower-extremity joint arthroplasty as well as to identify differences in PJI occurrence at different time periods. Patients and Methods: The Cochrane Library, CINAHL, MEDLINE, and PubMed were searched for literature published
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Mortality and Case Fatality Rates Associated With Surgical Site Infections: A Retrospective Surveillance Study. Surg. Infect. (IF 2.0) Pub Date : 2023-09-05 Costanza Vicentini,Heba Safwat Mhmoued Abdo Elhadidy,Noemi Marengo,Giovanni Paladini,Alessandro Roberto Cornio,Carla Maria Zotti
Background: Surgical site infections (SSIs) have been associated with increases in terms of costs, hospital stay, morbidity, and mortality. We aimed to assess trends in SSIs monitored through 10 years of surveillance activities in our region, and to describe mortality attributable to SSIs in the two most frequently monitored surgical procedures: colorectal surgery and hip arthroplasty. Methods: A retrospective
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Poor Oral Health in Trauma Intensive Care Unit Patients: Application of a Novel Oral Health Score. Surg. Infect. (IF 2.0) Pub Date : 2023-09-01 Kayli Quinton,Chelsea J Guy-Frank,Sophia Syed,James M Klugh,Naila H Dhanani,Shawn S Adibi,Lillian S Kao
Background: Although oral hygiene in patients in the intensive care unit (ICU) has been shown to reduce hospital-associated infections, baseline and progressive oral health are often not reported because of lack of a standardized tool. The Oral Health Risk Assessment Value Index (OHRAVI) is a comprehensive oral assessment validated by dental providers. This study hypothesizes that non-dental providers
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Post-Operative Increase in Serum Interleukin-6 Is Associated With Longer Hospital Stay in Children Operated on for Acute Appendicitis: A Pilot Study. Surg. Infect. (IF 2.0) Pub Date : 2023-09-01 Javier Arredondo Montero,Adriana Rivero Marcotegui,Carlos Bardají Pascual,Giuseppa Antona,Amaya Fernández-Celis,Natalia López-Andrés,Nerea Martín-Calvo
Background: Pediatric acute appendicitis (PAA) involves a substantial consumption of health and economic resources. The identification of serum biomarkers that may help predict the post-surgical evolution of these patients is a field of great interest. Patients and Methods: This was a prospective, observational substudy within the Biomarkers for the Diagnosis of Appendicitis in Pediatrics (BIDIAP)
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Microbiologic Analysis of Hand Infections: A Prospective Study. Surg. Infect. (IF 2.0) Pub Date : 2023-08-30 Susanne Rein,Anne Sorowka,Thomas Grünewald,Thomas Kremer
Background: Hand infections are a common problem in emergency departments. Staphylococcus aureus is the main pathogen of both hand and blood stream infections. Therefore, the aim of the present study was to evaluate the frequency and impact of bacteremia in patients with hand infections to improve the microbiologic diagnostics. Patients and Methods: A prospective study of 90 patients with acute hand
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Self-Reported Diagnosis and Management of Surgical Site Infection Highlights Lack of Objective Measures and Treatment Guidance. Surg. Infect. (IF 2.0) Pub Date : 2023-08-30 Patrick T Delaplain,Jeffrey Santos,Philip S Barie,Justin Dvorak,Tina S Mele,Rondi Gelbard,Christopher A Guidry,Sebastian D Schubl
Background: There is little guidance regarding empiric therapy for superficial surgical site infections (SSIs). Management of incisions with signs of SSI lacks consensus and management is variable among individual surgeons. Methods: The Surgical Infection Society was surveyed regarding management of SSIs. Cases were provided with varying wound descriptions, initial wound class (WC), post-operative
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Open Versus Laparoscopic Appendectomy: A Post Hoc Analysis of the EAST Appendicitis MUSTANG Study. Surg. Infect. (IF 2.0) Pub Date : 2023-08-30 Lauren Thompson,Brianna L Cohen,Tizeta Wolde,D Dante Yeh,Walter A Ramsey,Patricia M Byers,Nicholas Namias,Jonathan P Meizoso
Background: We sought to understand which factors are associated with open appendectomy as final operative approach. We hypothesize that higher American Association for the Surgery of Trauma (AAST) Emergency General Surgery (EGS) grade is associated with open appendectomy. Patients and Methods: Post hoc analysis of the Eastern Association for the Surgery of Trauma (EAST) Multicenter Study of the Treatment
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Nutritional and Inflammatory Indices and the Risk of Surgical Site Infection After Fragility Hip Fractures: Can Routine Blood Test Point to Patients at Risk? Surg. Infect. (IF 2.0) Pub Date : 2023-08-29 Tal Frenkel Rutenberg,Rana Gabarin,Vitali Kilimnik,Efrat Daglan,Moti Iflah,Shani Zach,Shai Shemesh
Background: Surgical site infection (SSI) after fragility hip fracture (FHF) surgery is associated with increased morbidity and mortality. We aim to utilize several established nutritional and inflammatory indices to characterize patients at risk. Patients and Methods: A retrospective cohort study of patients 65 years and older, who underwent surgery following FHFs between January 2012 and June 2020
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A Novel Protocol for Nasal Decolonization Using Prolonged Application of an Alcohol-Based Nasal Antiseptic Reduces Surgical Site Infections in Total Joint Arthroplasty Patients: A Retrospective Cohort Study. Surg. Infect. (IF 2.0) Pub Date : 2023-08-28 Phillip A Bostian,Justin Vaida,William C Brooks,Edwin Chaharbakhshi,Matthew J Dietz,Adam E Klein,T Ryan Murphy,Benjamin M Frye,Brock A Lindsey
Background: Current nasal decolonization strategies utilize pre-operative agents without consideration for short-term re-colonization or de novo colonization. Many strategies utilize an antibiotic-based agent, raising concerns of limited gram-negative antimicrobial coverage and the emergence of resistant bacterial strains. This study evaluated the clinical utility of a non-antibiotic, alcohol-based
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Use of Venovenous Extracorporeal Membrane Oxygenation in Patients With Acute Respiratory Distress Syndrome Caused by Fungal Pneumonia. Surg. Infect. (IF 2.0) Pub Date : 2023-08-18 Bridget Dillon,Jillian Wothe,Danika Evans,Karl Damroth,John Bohman,Ramiro Saavedra-Romero,Matthew Prekker,Melissa Brunsvold
Background: Patients with fungal pneumonias sometimes progress to acute respiratory distress syndrome (ARDS). Mortality has been reported as high as 60% to 90% in this group. Venovenous extracorporeal membrane oxygenation (VV-ECMO) can be used to support such patients, however, outcomes are not well understood. Patients and Methods: This was a retrospective study across the four adult ECMO centers
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Antimicrobial Activity of Silver-Containing Surgical Dressings in an In vitro Direct Inoculation Simulated Wound Fluid Model Against a Range of Gram-Positive and Gram-Negative Bacteria. Surg. Infect. (IF 2.0) Pub Date : 2023-08-16 Kate Meredith,Lucy Emma Forbes
Background: Surgical site infections can lead to serious complications and present a huge economic burden. Established wound infections can be difficult to eradicate so preventative measures, including antimicrobial dressings, are advantageous. Materials and Methods: The antimicrobial activity of an ionic silver, ethylenediaminetetraacetic acid (EDTA) and benzethonium chloride-containing (ISEB) surgical
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Risk Factors for Post-Operative Pulmonary Infection in Patients With Brain Tumors: A Systematic Review and Meta-Analysis. Surg. Infect. (IF 2.0) Pub Date : 2023-08-10 Jiangling Lan,Yan Wei,Yin Zhu,YuJiao Zhang,ShiZhen Zhang,LiGen Mo,DanDan Wei,Yi Lei
Background: This study aims to analyze the risk factors for post-operative pulmonary infection in patients with brain tumors by meta-analysis to provide a reference for its prevention. Methods: PubMed, Embase, Web of Science, Cochrane Library, Ovid, and four Chinese databases (CNKI, SinoMed, VIP, and Wanfang databases) were searched for studies covering risk factors of pulmonary infection in patients
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Understanding Herpes Simplex Virus Type 1 Versus Herpes Simplex Virus Type 2 Encephalitis After Neurosurgery: A Case Series and Literature Review. Surg. Infect. (IF 2.0) Pub Date : 2023-08-02 Noora Kazanji,Andrew Benvenuto,Daniel Rizk
Abstract Background: Herpes simplex virus encephalitis (HSVE) is a rare post-operative infection that can be fatal if treatment is delayed. Herpes simplex virus type 1 (HSV-1) is a more common cause of encephalitis than herpes simplex virus type 2 (HSV-2), however, a significant overlap exists. The goal of this project was to understand the frequency and trend of HSVE after neurosurgery through a case
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Impact of Bundled Intervention on Outcomes of Patients Undergoing Clean Orthopedic Surgeries With Hardware Implants: Small Prospective Randomized Controlled Trial. Surg. Infect. (IF 2.0) Pub Date : 2023-08-01 Benu Dhawan,Deepak Juyal,Jyoti Rawre,Maitrayee Narayan,Thirumurthy Velpandian,Vishnubhatla Sreenivas,Bhavuk Garg,Rajesh Malhotra
Background: Prosthesis-related infections (PRIs) and surgical site infections (SSIs) remain one of the most devastating complications among patients undergoing clean orthopedic surgeries. Prevention strategies are critical to reduce infection rates in orthopedic surgeries. The current study aimed to determine the effectiveness of a set of evidence-based practices (bundled intervention) in reducing
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Association Between Fecal Contamination and Outcomes After Emergent General Surgery Colorectal Resection: A Post Hoc Analysis of an Eastern Association for the Surgery of Trauma (EAST) Multicenter Study. Surg. Infect. (IF 2.0) Pub Date : 2023-07-25 Majid Chammas,Khaled Abdul Jawad,Gerd Daniel Pust,Rishi Rattan,Nicholas Namias,Brittany O Aicher,Brandon R Bruns,D Dante Yeh
Background: The impact of fecal contamination on clinical outcomes in patients undergoing emergent colorectal resection is unclear. We hypothesized that fecal contamination is associated with worse clinical outcomes regardless of operative technique. Patients and Methods: This is a post hoc analysis for an Eastern Association for the Surgery of Trauma-sponsored multicenter study that prospectively
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Biologic Versus Synthetic Mesh in Ventral Hernia Repair: Participant-Level Analysis of Two Randomized Controlled Trials at Twenty-Four to Thirty-Six Months. Surg. Infect. (IF 2.0) Pub Date : 2023-07-20 Naila H Dhanani,Kyung Hyun Lee,Oscar A Olavarria,Charlotte Young,Frank Primus,Julie L Holihan,Mike K Liang,Hobart W Harris
Background: Biologic mesh has been used increasingly in complex ventral hernia repair despite limited evidence at low risk of bias supporting its use. Patients and Methods: We performed a participant-level analysis of published randomized controlled trials (RCTs) comparing biologic to synthetic mesh with complex ventral hernia repair at 24 to 36 months. Primary outcome was major complication (composite
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Persistent Proclivity to a Proinflammatory State in a Human Enteroid Model of Necrotizing Enterocolitis. Surg. Infect. (IF 2.0) Pub Date : 2023-07-18 K Brooke Snyder,Alena Golubkova,Tyler Leiva,Chase Calkins,Heather Liebe,Camille Schlegel,Catherine J Hunter
Background: Necrotizing enterocolitis (NEC) is a devastating disease of premature neonates with substantial morbidity and mortality. Necrotizing enterocolitis is associated with prematurity, a hyperinflammatory response, and dysregulation of intestinal barrier function. We hypothesize that patients with NEC will have an increased hyperinflammatory intestinal response compared with those without NEC
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Different Surgeon, Different Closure: Lack of Consensus on Appropriate Closure Technique for Various Case Scenarios. Surg. Infect. (IF 2.0) Pub Date : 2023-07-18 Jeffrey Santos,Patrick T Delaplain,Philip S Barie,Justin Dvorak,Tina S Mele,Rondi Gelbard,Christopher A Guidry,Sebastian D Schubl
Background: Many techniques for closure of surgical incisions are available to the surgeon, but there is minimal guidance regarding which technique(s) should be utilized at the conclusion of surgery and under what circumstances. Hypothesis: Management of incisions at the conclusion of surgery lacks consensus and varies among individual surgeons. Methods: The Surgical Infection Society membership was
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Risk Factors for Surgical Site Complications After Outpatient Lumbar Spine Surgery. Surg. Infect. (IF 2.0) Pub Date : 2023-07-12 Megan Hoffman,Jennifer Lanza,Samantha J Simon,Lauren Schoeller,Christopher Fang,Gloria Coden,Brian Hollenbeck
Background: With the recent increase of minor lumbar spine surgeries being performed in the outpatient setting, there is a need for information on factors that contribute to post-operative complications for these surgeries. Patients and Methods: This was a prospective observational study examining risk factors for self-reported post-operative drainage in patients who underwent lumbar spine surgery
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Diagnostic Values of Peripheral Blood T-Cell Spot Test for Tuberculosis (T-SPOT.TB) for Spinal Tuberculosis. Surg. Infect. (IF 2.0) Pub Date : 2023-07-12 Tiantian Xu,Qi Lai,Ning Qu,Bin Zhang,Qihua Qi
Background: The T-cell spot test for tuberculosis (T-SPOT.TB) with false positives and false negatives exists in the diagnosis of spinal infection. The objective of this study was to increase the diagnostic value precision and specificity of T-SPOT.TB in the identification of spinal tuberculosis (TB). Patients and Methods: Fifty-two patients suspected of having spinal TB from April 2020 to December
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Letter to the Editor: Factors Impacting Coronavirus Disease 2019 Vaccine Hesitancy: Comment. Surg. Infect. (IF 2.0) Pub Date : 2023-06-20 Amnuay Kleebayoon,Viroj Wiwanitkit
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Letter to the Editor: Primary Parotid Tuberculosis Masquerading as a Benign Neoplasm. Surg. Infect. (IF 2.0) Pub Date : 2023-06-20 Ying Si,Bo Sun,Ke Xiao,Yongmao Huang
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Risk Factors for Surgical Site Infections After Single-Level Anterior Lumbar Interbody Fusion. Surg. Infect. (IF 2.0) Pub Date : 2023-06-15 Danny Lee,Ryan Lee,Jeffrey Weinreb,Eric Chalif,Neil Mohile,Jessica H Heyer,Joseph O'Brien
Abstract Background: Anterior lumbar interbody fusion (ALIF) has become an increasingly popular and effective treatment modality for various conditions of the lumbar spine. However, complications after this procedure can be costly. Surgical site infections (SSIs) are one of these types of complications. The present study identifies independent risk factors for SSI after single-level ALIF to identify
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Trends and Prediction of Surgical Site Infection After Elective Spine Surgery: An Analysis of the American College of Surgeons National Surgical Quality Improvement Project Database. Surg. Infect. (IF 2.0) Pub Date : 2023-06-13 Kenneth E Stewart,Rui Terada,Casey Windrix,Louis Ma,Marcos Gomes,Amir Butt,Kenichi A Tanaka
Background: Surgical site infection (SSI) is an infrequent but costly complication after elective spine surgery. Identification of important temporal changes and predictive factors may inform targeted prevention efforts. Patients and Methods: A retrospective study of elective spine surgery patients was performed using the National Surgical Quality Improvement Programs (NSQIP) database from 2011 and