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Inhibitory effects of medium‐chain fatty acids on the proliferation of human breast cancer cells via suppression of Akt/mTOR pathway and modulating the Bcl‐2 family protein J. Cell. Biochem. (IF 4.0) Pub Date : 2024-04-26 P. G. Roopashree, Shilpa S. Shetty, Vijith Vittal Shetty, P. C. Suhasini, Kumari N. Suchetha
Medium‐chain fatty acids (MCFAs) have 6–12 carbon atoms and are instantly absorbed into the bloodstream before traveling to the portal vein and the liver, where they are immediately used for energy and may have antitumor effects. Its role in breast cancer is poorly understood. To investigate the apoptosis‐inducing effect of MCFAs in breast cancer cells, cell viability assay, colony formation assay
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HN1 is a novel dedifferentiation factor involved in regulating the cell cycle and microtubules in SH‐SY5Y neuroblastoma cells J. Cell. Biochem. (IF 4.0) Pub Date : 2024-04-17 Tilbe Özar, Aadil Javed, Gülseren Özduman, Kemal S. Korkmaz
Hematological and neurological expressed 1 (HN1), encoding a small protein, has been recently explored in different cancers owing to its higher expression in tumor samples as compared to adjacent normal. It was discovered and subsequently named because of its higher expression in hematological and neurological tissues in developing mice. Following discovery, it was considered a neuronal regeneration
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RUNX1 regulates promoter activity in the absence of cognate DNA binding motifs J. Cell. Biochem. (IF 4.0) Pub Date : 2024-04-15 Alex M. Woodworth, Kristine Hardy, Phillippa C. Taberlay, Joanne L. Dickinson, Adele F. Holloway
Runt‐related transcription factor 1 (RUNX1) plays an important role in normal haematopoietic cell development and function, and its function is frequently disrupted in leukaemia. RUNX1 is widely recognised as a sequence‐specific DNA binding factor that recognises the motif 5′‐TG(T/C)GGT‐3′ in promoter and enhancer regions of its target genes. Moreover, RUNX1 fusion proteins, such as RUNX1‐ETO formed
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PPARγ inhibition promotes osteogenic differentiation of bone marrow mesenchymal stem cells and fracture healing J. Cell. Biochem. (IF 4.0) Pub Date : 2024-04-15 Guohui Yang, Kexi Liu, Shengli Ma, Peiyi Qi
This study aimed to explore the effects of peroxisome proliferator‐activated receptor γ (PPARγ) inhibition on fracture healing of nonunion and the underlying mechanisms. Bone marrow mesenchymal stem cells (BMSCs) were treated with PPARγ antagonist GW9662 (5 μM, 10 μM). Alkaline phosphatase (ALP) staining and Alizarin Red S was used to assess early stage of osteogenesis and osteogenic differentiation
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Obesity‐dependent molecular alterations in fatal COVID‐19: A retrospective postmortem study of metabolomic profile of adipose tissue J. Cell. Biochem. (IF 4.0) Pub Date : 2024-04-09 Bruna I. Pilger, Alex Castro, Franciane F. Vasconcellos, Karen F. Moura, Étore De Favari Signini, Luis Felipe B. Marqueze, Edson A. Fiorenza‐Neto, Mateus T. Rocha, Giulia S. Pedroso, Claudia R. Cavaglieri, Antonio G. Ferreira, Caique Figueiredo, Luciele G. Minuzzi, Guilherme H. Gatti da Silva, Gabriela S. Castro, Fábio S. Lira, Marilia Seelaender, Ricardo A. Pinho
We investigated the effects of obesity on metabolic, inflammatory, and oxidative stress parameters in the adipose tissue of patients with fatal COVID‐19. Postmortem biopsies of subcutaneous adipose tissue were obtained from 25 unvaccinated inpatients who passed from COVID‐19, stratified as nonobese (N‐OB; body mass index [BMI], 26.5 ± 2.3 kg m−2) or obese (OB BMI 34.2 ± 5.1 kg m−2). Univariate and
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Retraction: “H19 suppresses the growth of hepatoblastoma cells by promoting their apoptosis via the signaling pathways of miR‐675/FADD and miR‐138/PTK2” J. Cell. Biochem. (IF 4.0) Pub Date : 2024-04-09
Retraction: “H19 suppresses the growth of hepatoblastoma cells by promoting their apoptosis via the signaling pathways of miR‐675/FADD and miR‐138/PTK2” by Lili Ge, Xianwei Zhang, Shengnan Hu, Yinsen Song, Jinghui Kong, Bo Zhang, Xiaoang Yang, J Cell Biochem 2019, 120: 5218‐5231. The above article, published online on 26 October 2018 in Wiley Online Library (https://doi.org/10.1002/jcb.27797) has been
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Retraction: “Downregulation of long noncoding RNA SNHG1 inhibits cell proliferation, metastasis, and invasion by suppressing the Notch‐1 signaling pathway in pancreatic cancer” J. Cell. Biochem. (IF 4.0) Pub Date : 2024-04-09
Retraction: “Downregulation of long noncoding RNA SNHG1 inhibits cell proliferation, metastasis, and invasion by suppressing the Notch‐1 signaling pathway in pancreatic cancer” by Long Cui, Yadong Dong, Xiaochuan Wang, Xin Zhao, Chenchen Kong, Yangsui Liu, Xinchun Jiang, Xinhui Zhang, J Cell Biochem 2019, 120: 6106‐6112. The above article, published online on 5 December 2018 in Wiley Online Library
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Activation of heme oxygenase‐1 by laminar shear stress ameliorates high glucose‐induced endothelial cell and smooth muscle cell dysfunction J. Cell. Biochem. (IF 4.0) Pub Date : 2024-04-09 Hung‐Che Chien, Yu‐Lin Wang, Yun‐Chin Tu, Pi‐Fen Tsui, Min‐Chien Tsai
High glucose (HG)‐induced endothelial cell (EC) and smooth muscle cell (SMC) dysfunction is critical in diabetes‐associated atherosclerosis. However, the roles of heme oxygenase‐1 (HO‐1), a stress‐response protein, in hemodynamic force‐generated shear stress and HG‐induced metabolic stress remain unclear. This investigation examined the cellular effects and mechanisms of HO‐1 under physiologically
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Retraction: ‘MicroRNA‐198 Inhibits Proliferation and Induces Apoptosis of Lung Cancer Cells Via Targeting FGFR1’ J. Cell. Biochem. (IF 4.0) Pub Date : 2024-04-09
(https://onlinelibrary.wiley.com/doi/10.1002/jcb.24742) has been retracted by agreement between the journal's Editor in Chief, Christian Behl, and Wiley Periodicals LLC.The retraction has been agreed following an investigation based on allegations raised by a third party. Several flaws and inconsistencies between results presented and experimental methods described were found. Thus, the editors consider
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Irisin influences the in vitro differentiation of human mesenchymal stromal cells, promoting a tendency toward beiging adipogenesis J. Cell. Biochem. (IF 4.0) Pub Date : 2024-04-09 Girolamo Di Maio, Nicola Alessio, Alessia Ambrosino, Sura H. A. Al Sammarraie, Marcellino Monda, Giovanni Di Bernardo
Mammals exhibit two distinct types of adipose depots: white adipose tissue (WAT) and brown adipose tissue (BAT). While WAT primarily functions as a site for energy storage, BAT serves as a thermogenic tissue that utilizes energy and glucose consumption to regulate core body temperature. Under specific stimuli such as exercise, cold exposure, and drug treatment, white adipocytes possess a remarkable
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J. Cell. Biochem. (IF 4.0) Pub Date : 2024-04-08
This article corrects the following: The new role of riluzole in the treatment of pancreatic cancer through the apoptosis and autophagy pathways Rulin Sun, Xujun He, Xiaoting Jiang, Houquan Tao J Cell Biochem 2021; 122: 934–944. doi:10.1002/jcb.29533 First Published online: November 11, 2019 In the original version of this article, the authors selected the wrong image to depict migration inhibition
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Withdrawn: LncRNA LUADT1 regulates miR-34a/SIRT1 to participate in chondrocyte apoptosis J. Cell. Biochem. (IF 4.0) Pub Date : 2024-04-03
Withdrawn: ‘LncRNA LUADT1 regulates miR-34a/SIRT1 to participate in chondrocyte apoptosis’ by Su Ni, Chao Xu, Chao Zhuang, Gongyin Zhao, Chenkai Li, Yuji Wang, Xihu Qin, J Cell Biochem (https://doi.org/10.1002/jcb.29637). The above article, published online on 7 February 2020 in Wiley Online Library (https://onlinelibrary.wiley.com/doi/10.1002/jcb.29637) has been withdrawn by agreement between the
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Retraction: ‘miRNA‐200b improves hepatic fibrosis induced by CCL4 by regulating toll‐like receptor 4 in mice’ J. Cell. Biochem. (IF 4.0) Pub Date : 2024-04-08
The above article, published online on 28 March 2019 in Wiley Online Library (https://onlinelibrary.wiley.com/doi/full/10.1002/jcb.28599) has been retracted by agreement between the journal's Editor in Chief, Christian Behl, and Wiley Periodicals LLC.The retraction has been agreed following an investigation based on allegations raised by a third party. Several flaws and inconsistencies between results
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Exploring neuroadaptive cellular pathways in chronic morphine exposure: An in‐vitro analysis of cabergoline and Mdivi‐1 co‐treatment effects on the autophagy–apoptosis axis J. Cell. Biochem. (IF 4.0) Pub Date : 2024-04-05 Mina Makvand, Seyed Davood Mirtorabi, Arezoo Campbell, Alireza Zali, Ghasem Ahangari
The complex impacts of prolonged morphine exposure continue to be a significant focus in the expanding area of addiction studies. This research investigates the effectiveness of a combined treatment using Cabergoline and Mdivi‐1 to counteract the neuroadaptive changes caused by in vitro morphine treatment. The impact of Methadone, Cabergoline, and a combination of Cabergoline and Mdivi‐1 on the cellular
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Retraction: ‘Downregulation of miR‐218 by nicotine promotes cell proliferation through targeting CDK6 in non–small cell lung cancer’ J. Cell. Biochem. (IF 4.0) Pub Date : 2024-04-05
Downregulation of miR‐218 by nicotine promotes cell proliferation through targeting CDK6 in non–small cell lung cancer, by Zhen Liu, Cuiling Lu, Guanren Zhao, Xue Han, Kaisheng Dong, Chuanhai Wang, Jing‐Zhi Guan, Zhongyuan Wang, J Cell Biochem. 2019; 120: 18370‐18377: The above article, published online on 12 June 2019 in Wiley Online Library (https://onlinelibrary.wiley.com/doi/full/10.1002/jcb.29148)
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Retraction: “MicroRNA‐205 affects mouse granulosa cell apoptosis and estradiol synthesis by targeting CREB1” J. Cell. Biochem. (IF 4.0) Pub Date : 2024-04-03
Retraction: “MicroRNA‐205 affects mouse granulosa cell apoptosis and estradiol synthesis by targeting CREB1,” by Pengju Zhang, Jun Wang, Hongyan Lang, Weixia Wang, Xiaohui Liu, Haiyan Liu, Chengcheng Tan, Xintao Li, Yumin Zhao, Xinghong Wu, J Cell Biochem. 2018; 120: 8466‐8474: The above article, published online on 16 December 2018 in Wiley Online Library (https://onlinelibrary.wiley.com/doi/full/10
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Retraction: “Quercetin improve ischemia/reperfusion‐induced cardiomyocyte apoptosis in vitro and in vivo study via SIRT1/PGC‐1α signaling” J. Cell. Biochem. (IF 4.0) Pub Date : 2024-04-03
Retraction: “Quercetin improve ischemia/reperfusion‐induced cardiomyocyte apoptosis in vitro and in vivo study via SIRT1/PGC‐1α signaling”, by Jiayou Tang, Linhe Lu, Yang Liu, Jipeng Ma, Lifang Yang, Lanlan Li, Hong Guo, Shiqiang Yu, Jun Ren, Heping Bai, Jian Yang, J Cell Biochem. 2019; 120: 9747‐9757: The above article, published online on 17 January 2019 in Wiley Online Library (https://onlinelibrary
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Retraction: “MiR‐137 functions as a tumor suppressor in pancreatic cancer by targeting MRGBP” J. Cell. Biochem. (IF 4.0) Pub Date : 2024-04-01
Retraction: “MiR‐137 functions as a tumor suppressor in pancreatic cancer by targeting MRGBP” by Feng Ding, Shuang Zhang, Shaoyang Gao, Jian Shang, Yanxia Li, Ning Cui, and Qiu Zhao, J Cell Biochem. 2018; 4799‐4807: The above article, published online on 13 January 2018 in Wiley Online Library (https://doi.org/10.1002/jcb.26676) has been retracted by agreement between the journal's Editor in Chief
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The long noncoding RNA TPTE2P1 promotes the viability of colorectal cancer cells J. Cell. Biochem. (IF 4.0) Pub Date : 2024-04-01
In the original version of this article, the authors wrongly assembled panels for the Western Blots presented in Figure 5. The loading controls chosen do not originate from the same blots depicting the expression levels of the proteins of interest. The correct Figure 5 is shown below. Figure 5 Open in figure viewerPowerPoint This correction doesn't change the results and conclusions. The authors
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Expression of exosomal microRNAs during chondrogenic differentiation of human bone mesenchymal stem cells J. Cell. Biochem. (IF 4.0) Pub Date : 2024-04-01
Hao Sun, Shu Hu, Ziji Zhang, Jiayong Lun, Weiming Liao, Zhiqi Zhang In the original version of this article, the authors wrongly assembled Figure 5A resulting in the IHC staining of SOX9 for the hBMSC-320c-Exos group to be mistakenly used in both Figures 5A and 5B. The correct Figure 5A is shown below. Figure 5A Open in figure viewerPowerPoint This correction doesn't change the results and conclusions
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State‐of‐the‐art in transposable element modulation affected by drugs in malignant prostatic cancer cells J. Cell. Biochem. (IF 4.0) Pub Date : 2024-03-19 Anna Terrazzan, Riccardo Vanini, Pietro Ancona, Nicoletta Bianchi, Cristian Taccioli, Gianluca Aguiari
Over recent years, the investigation of transposable elements (TEs) has granted researchers a deeper comprehension of their characteristics and functions, particularly regarding their significance in the mechanisms contributing to cancer development. This manuscript focuses on prostate carcinoma cell lines and offers a comprehensive review intended to scrutinize the associations and interactions between
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Neuregulin 4 (Nrg4) cooperates with melatonin to regulate the PRL expression via ErbB4/Erk signaling pathway as a potential prolactin (PRL) regulator J. Cell. Biochem. (IF 4.0) Pub Date : 2024-03-11 Wen‐wen Lin, Guan‐yong Ou, Hui‐fang Dai, Wei‐jiang Zhao
Neuregulin‐4 (Nrg4) and melatonin play vital roles in endocrine diseases. However, there is little discussion about the function and potential mechanism of Nrg4 and melatonin in prolactin (PRL) regulation. The human normal pituitary data from Gene Expression Profiling Interactive Analysis (GEPIA) database was used to explore the correlation between NRG4 and PRL. The expression and correlation of NRG4
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Roles of PD-L1 in human adipose-derived mesenchymal stem cells under inflammatory microenvironment J. Cell. Biochem. (IF 4.0) Pub Date : 2024-03-07 Jinqiu Sun, Hannah Zhong, Bo Kang, Trenton Lum, Dongxue Liu, Shengxian Liang, Jijun Hao, Rui Guo
Mesenchymal stem cells (MSCs) display unique homing and immunosuppression features which make them promising candidates for cell therapy in inflammatory disorders. It is known that C-X-C chemokine receptor type 4 (CXCR4, also known as CD184) is a critical receptor implicated in MSCs migration, and the protein programmed death ligand-1 (PD-L1) is involved in MSC's immunosuppression. However, it remains
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AP‐1/C‐FOS and AP‐1/FRA2 differentially regulate early and late adipogenic differentiation of mesenchymal stem cells J. Cell. Biochem. (IF 4.0) Pub Date : 2024-03-05 Ganesh Suraj Bose, Garima Kalakoti, Abhijeet P. Kulkarni, Smriti Mittal
Obesity is defined as an abnormal accumulation of adipose tissue in the body and is a major global health problem due to increased morbidity and mortality. Adipose tissue is made up of adipocytes, which are fat‐storing cells, and the differentiation of these fat cells is known as adipogenesis. Several transcription factors (TFs) such as CEBPβ, CEBPα, PPARγ, GATA, and KLF have been reported to play
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InR and Pi3K maintain intestinal homeostasis through STAT/EGFR and Notch signaling in enteroblasts J. Cell. Biochem. (IF 4.0) Pub Date : 2024-03-04 Jiewei Wang, Hongmei Xue, Xinyu Yi, Hyonil Kim, Yangguang Hao, Li Hua Jin
To maintain the integrity of the adult gut, the proliferation and differentiation of stem cells must be strictly controlled. Several signaling pathways control the proliferation and differentiation of Drosophila intestinal epithelial cells. Although the modulatory effects of insulin pathway components on cell proliferation have been characterized, their specific role in which cell type and how these
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The molecular circadian rhythms regulating the cell cycle J. Cell. Biochem. (IF 4.0) Pub Date : 2024-02-19 Qin Zhou, Ruohan Wang, Yunxia Su, Bowen Wang, Yunfei Zhang, Ximing Qin
The circadian clock controls the expression of a large proportion of protein-coding genes in mammals and can modulate a wide range of physiological processes. Recent studies have demonstrated that disruption or dysregulation of the circadian clock is involved in the development and progression of several diseases, including cancer. The cell cycle is considered to be the fundamental process related
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Continuous genetic monitoring of transient mesenchymal gene activities in distal tubule and collecting duct epithelial cells during renal fibrosis J. Cell. Biochem. (IF 4.0) Pub Date : 2024-02-19 Zihang Xu, Shaotong Zhang, Tingting Han, Letong Cai, Simin Zhong, Xiaojie Yang, Shaohua Zhang, Yan Li, Kuo Liu, Bin Zhou, Xueying Tian
Epithelial cells (ECs) have been proposed to contribute to myofibroblasts or fibroblasts through epithelial-mesenchymal transition (EMT) during renal fibrosis. However, since EMT may occur dynamically, transiently, and reversibly during kidney fibrosis, conventional lineage tracing based on Cre-loxP recombination in renal ECs could hardly capture the transient EMT activity, yielding inconsistent results
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Selection of internalizing RNA aptamers into human breast cancer cells derived from primary sites J. Cell. Biochem. (IF 4.0) Pub Date : 2024-02-19 Pricila da Silva Cunha, Marcelo Coutinho de Miranda, Mariane Izabella Abreu de Melo, Andrea da Fonseca Ferreira, Joana Lobato Barbosa, Junnia Alvarenga de Carvalho Oliveira, Tércio de Souza Goes, Dawidson Assis Gomes, Alfredo Miranda de Goes
Breast cancer is the most common cancer in women. Although chemotherapy is still broadly used in its treatment, adverse effects remain a challenge. In this scenario, aptamers emerge as a promising alternative for theranostic applications. Studies using breast cancer cell lines provide useful information in laboratory and preclinical investigations, most of which use cell lines established from metastatic
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Identification of putative antiviral bioactive compounds derived from family Asteraceae: An in silico approach J. Cell. Biochem. (IF 4.0) Pub Date : 2024-02-18 Swati Srivastava, Mohd Shahnawaz Khan, Saheem Ahmad, Amit Dubey, Vijay Laxmi Saxena, Mohammad Haneef
This computational study investigates 21 bioactive compounds from the Asteraceae family as potential inhibitors targeting the Spike protein (S protein) of SARS-CoV-2. Employing in silico methods and simulations, particularly CDOCKER and MM-GBSA, the study identifies two standout compounds, pterodontic acid and cichoric acid, demonstrating robust binding affinities (−46.1973 and −39.4265 kcal/mol) against
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Induction of stearoyl-CoA desaturase confers cell density-dependent ferroptosis resistance in melanoma J. Cell. Biochem. (IF 4.0) Pub Date : 2024-02-16 Hitomi Shirahama, Yuri Tani, Satomi Tsukahara, Yuka Okamoto, Akiko Hasebe, Tomomiki Noda, Shuji Ando, Masaru Ushijima, Masaaki Matsuura, Akihiro Tomida
Ferroptosis is a form of regulated cell death that is induced by inhibiting glutathione peroxidase 4 (GPX4), which eliminates lipid peroxidation. Ferroptosis induction is influenced by the cell environment. However, the cellular states altering ferroptosis susceptibility remain largely unknown. We found that melanoma cell lines became resistant to ferroptosis as cell density increased. Comparative
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Novel oncogenic transcriptional targets of mutant p53 in esophageal squamous cell carcinoma J. Cell. Biochem. (IF 4.0) Pub Date : 2024-02-15 Sara A. George, Viswakalyan Kotapalli, Pandilla Ramaswamy, Raju Kumar, Swarnalata Gowrishankar, Shantveer G. Uppin, Murali D. Bashyam
Missense mutations in the DNA binding domain of p53 are observed frequently in esophageal squamous cell carcinoma (ESCC). Recent studies have revealed the potentially oncogenic transcriptional networks regulated by mutant p53 proteins. However, majority of these studies have focused on common “hotspot” p53 mutations while rarer mutations are poorly characterized. In this study, we report the characterization
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Cannabidiol activates MAPK pathway to induce apoptosis, paraptosis, and autophagy in colorectal cancer cells J. Cell. Biochem. (IF 4.0) Pub Date : 2024-02-15 Na Young Kim, Chakrabhavi Dhananjaya Mohan, Gautam Sethi, Kwang Seok Ahn
Mitogen-activated protein kinase (MAPK) activation by natural compounds is known to be involved in the induction of apoptosis, paraptosis, and autophagy. Cannabidiol (CBD), a bioactive compound found in Cannabis sativa, is endowed with many pharmacological activities. We investigated the cytotoxic effect of CBD in a panel of colorectal cancer (CRC) cells (HT-29, SW480, HCT-116, and HCT-15). CBD induced
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Intrinsic factors behind long COVID: IV. Hypothetical roles of the SARS-CoV-2 nucleocapsid protein and its liquid–liquid phase separation J. Cell. Biochem. (IF 4.0) Pub Date : 2024-02-13 Ahmed Eltayeb, Faisal Al-Sarraj, Mona Alharbi, Raed Albiheyri, Ehab H. Mattar, Isam M. Abu Zeid, Thamer A. Bouback, Atif Bamagoos, Vladimir N. Uversky, Alberto Rubio-Casillas, Elrashdy M. Redwan
When the SARS-CoV-2 virus infects humans, it leads to a condition called COVID-19 that has a wide spectrum of clinical manifestations, from no symptoms to acute respiratory distress syndrome. The virus initiates damage by attaching to the ACE-2 protein on the surface of endothelial cells that line the blood vessels and using these cells as hosts for replication. Reactive oxygen species levels are increased
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BRG1 mediates epigenetic regulation of TNFα-induced CCL2 expression in oral tongue squamous cell carcinoma cells J. Cell. Biochem. (IF 4.0) Pub Date : 2024-02-13 Mingyan Xu, Xuemei Lu, Feixiang Zhu, Xue Sun, Hongfa Yao, Junling Zhang, Weishi Chen, Haohao Zhu, Fan Liu, Song Lin Shi, Xiaoling Deng
Strong evidence has indicated that upregulation of chemokine (CC motif) ligand-2 (CCL2) expression and the presence of an inflammatory tumor microenvironment significantly contribute to the migratory and invasive properties of oral squamous cell carcinoma, specifically oral tongue squamous cell carcinoma (OTSCC). However, the precise epigenetic mechanism responsible for enhanced CCL2 expression in
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Repurposing FDA-approved drugs to target malaria through inhibition of dihydrofolate reductase in the folate biosynthesis pathway: A prospective approach J. Cell. Biochem. (IF 4.0) Pub Date : 2024-02-12 Kanika Verma, Rini Chaturvedi, Ayush K. Lahariya, Anil K. Verma, Kristan A. Schneider, Anup R. Anvikar, Praveen K. Bharti
Dihydrofolate reductase (DHFR) is a ubiquitous enzyme that regulates the biosynthesis of tetrahydrofolate among various species of Plasmodium parasite. It is a validated target of the antifolate drug pyrimethamine (Pyr) in Plasmodium falciparum (Pf), but its clinical efficacy has been hampered due to the emergence of drug resistance. This has made the attempt to screen Food & Drug Administration-approved
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Mechanotransduction and epigenetic modulations of chromatin: Role of mechanical signals in gene regulation J. Cell. Biochem. (IF 4.0) Pub Date : 2024-02-12 Jagdish Mishra, Subhajit Chakraborty, Niharika, Ankan Roy, Soumen Manna, Tirthankar Baral, Piyasa Nandi, Samir K. Patra
Mechanical forces may be generated within a cell due to tissue stiffness, cytoskeletal reorganization, and the changes (even subtle) in the cell's physical surroundings. These changes of forces impose a mechanical tension within the intracellular protein network (both cytosolic and nuclear). Mechanical tension could be released by a series of protein–protein interactions often facilitated by membrane
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Helicobacter pylori CagA protein induces gastric cancer stem cell-like properties through the Akt/FOXO3a axis J. Cell. Biochem. (IF 4.0) Pub Date : 2024-02-08 Zheng-wei Chen, Zhe-bin Dong, Han-ting Xiang, Sang-sang Chen, Wei-ming Yu, Chao Liang
The presence of Helicobacter pylori (H. pylori) infection poses a substantial risk for the development of gastric adenocarcinoma. The primary mechanism through which H. pylori exerts its bacterial virulence is the cytotoxin CagA. This cytotoxin has the potential to induce inter-epithelial mesenchymal transition, proliferation, metastasis, and the acquisition of stem cell-like properties in gastric
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Identification of potent BRD4-BD1 inhibitors using classical and steered molecular dynamics based free energy analysis J. Cell. Biochem. (IF 4.0) Pub Date : 2024-02-05 Ashish Gupta, Rituraj Purohit
In the present work a combination of traditional and steered molecular dynamics based techniques were employed to identify potential inhibitors against the human BRD4 protein (BRD4- BD1); an established drug target for multiple illnesses including various malignancies. Quinoline derivatives that were synthesized in-house were tested for their potential as new BRD4-BD1 inhibitors. Initially molecular
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Palmitoylation is required for Sept8-204 and Sept5 to form vesicle-like structure and colocalize with synaptophysin J. Cell. Biochem. (IF 4.0) Pub Date : 2024-02-03 Huicong Liu, Rong Tan, Jia Tong, Shuo Wen, Can Wu, Muding Rao, Jiangli Zhu, Shiqian Qi, Eryan Kong
Sept8 is a vesicle associated protein and there are two typical transcriptional variants (Sept8-204 and Sept8-201) expressed in mice brain. Interestingly, the coexpression of Sept8-204/Sept5 induces the formation of small sized vesicle-like structure, while that of the Sept8-201/Sept5 produces large puncta. Sept8 is previously shown to be palmitoylated. Here it was further revealed that protein palmitoylation
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DON/DRP-104 as potent serine protease inhibitors implicated in SARS-CoV-2 infection: Comparative binding modes with human TMPRSS2 and novel therapeutic approach J. Cell. Biochem. (IF 4.0) Pub Date : 2024-01-29 Ernest Oduro-Kwateng, Mahmoud E. Soliman
Human transmembrane serine protease 2 (TMPRSS2) is an important member of the type 2 transmembrane serine protease (TTSP) family with significant therapeutic markings. The search for potent TMPRSS2 inhibitors against severe acute respiratory syndrome coronavirus 2 infection with favorable tissue specificity and off-site toxicity profiles remains limited. Therefore, probing the anti-TMPRSS2 potential
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In silico analysis of alpha-synuclein protein variants and posttranslational modifications related to Parkinson's disease J. Cell. Biochem. (IF 4.0) Pub Date : 2024-01-18 Aloma N. R. da Silva, Gabriel R. C. Pereira, Luiz Felippe Sarmento Bonet, Tiago Fleming Outeiro, Joelma F. De Mesquita
Parkinson's disease (PD) is among the most prevalent neurodegenerative disorders, affecting over 10 million people worldwide. The protein encoded by the SNCA gene, alpha-synuclein (ASYN), is the major component of Lewy body (LB) aggregates, a histopathological hallmark of PD. Mutations and posttranslational modifications (PTMs) in ASYN are known to influence protein aggregation and LB formation, possibly
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Metformin ameliorates mitochondrial damage induced by C9orf72 poly(GR) via upregulating AKT phosphorylation J. Cell. Biochem. (IF 4.0) Pub Date : 2024-01-17 Yiyuan Feng, Zhongyun Xu, Hongfu Jin, Yuanyuan Chen, Chenglai Fu, Yu Zhang, Yafu Yin, Hui Wang, Weiwei Cheng
Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are devastating neurodegenerative diseases with no effective cure. GGGGCC repeat expansion in C9orf72 is the most common genetic cause of both ALS and FTD. A key pathological feature of C9orf72 related ALS/FTD is the presence of abnormal dipeptide repeat proteins translated from GGGGCC repeat expansion, including poly Glycine-Arginine
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TBC1D2B undergoes phase separation and mediates autophagy initiation J. Cell. Biochem. (IF 4.0) Pub Date : 2024-01-16 Marina E. Hoffmann, Anne-Claire Jacomin, Doris Popovic, Daniel Kalina, Adriana Covarrubias-Pinto, Ivan Dikic
Small ubiquitin-like modifiers from the ATG8 family regulate autophagy initiation and progression in mammalian cells. Their interaction with LC3-interacting region (LIR) containing proteins promotes cargo sequestration, phagophore assembly, or even fusion between autophagosomes and lysosomes. Previously, we have shown that RabGAP proteins from the TBC family directly bind to LC3/GABARAP proteins. In
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Clock gene Per2 modulates epidermal tissue repair in vivo J. Cell. Biochem. (IF 4.0) Pub Date : 2024-01-16 Veronica Quispe Yujra, Ericka Janine Dantas da Silveira, Daniel Araki Ribeiro, Rogerio Moraes Castilho, Cristiane Helena Squarize
Wound healing can be influenced by genes that control the circadian cycle, including Per2 and BMAL1, which coordinate the functions of several organs, including the skin. The aim of the study was to evaluate the role of PER2 during experimental skin wound healing. Two groups (control and Per2-KO), consisting of 14 male mice each, were anesthetized by inhalation, and two 6 mm wounds were created on
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Pyruvate maintains and enhances the pro-inflammatory response of microglia caused by glucose deficiency in early stroke J. Cell. Biochem. (IF 4.0) Pub Date : 2024-01-16 Peng Zhou, Zhe-Cheng Yu, Cong Cao, Huai-Rui Cui, Mao-Chao Ding, Chao-Xian Yang, Min Liao
Pro-inflammatory microglia mainly rely on glycolysis to maintain cytokine production during ischemia, accompanied by an increase in inducible nitric oxide synthase (iNOS) and monocarboxylate transporter 1 (MCT1). The role of energy metabolism in the pro-inflammatory response of microglia is currently unclear. In this study, we tested the response of microglia in mice after cerebral ischemia and simulated
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Gastric cancer mesenchymal stem cells promote tumor glycolysis and chemoresistance by regulating B7H3 in gastric cancer cells J. Cell. Biochem. (IF 4.0) Pub Date : 2024-01-16 Qiuzhi Gao, Chao Huang, Ting Liu, Fumeng Yang, Zhihong Chen, Li Sun, Yuanyuan Zhao, Mei Wang, Liqi Luo, Chenglin Zhou, Wei Zhu
Despite surgical treatment combined with multidrug therapy having made some progress, chemotherapy resistance is the main cause of recurrence and death of gastric cancer (GC). Gastric cancer mesenchymal stem cells (GCMSCs) have been reported to be correlated with the limited efficacy of chemotherapy in GC, but the mechanism of GCMSCs regulating GC resistance needs to be further studied. The gene set
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The BCKDH kinase inhibitor BT2 promotes BCAA disposal and mitochondrial proton leak in both insulin-sensitive and insulin-resistant C2C12 myotubes J. Cell. Biochem. (IF 4.0) Pub Date : 2024-01-16 Caroline N. Rivera, Carly E. Smith, Lillian V. Draper, Madison E. Kee, Norah E. Cook, Macey R. McGovern, Rachel M. Watne, Andrew J. Wommack, Roger A. Vaughan
Elevated circulating branched-chain amino acids (BCAAs) have been correlated with the severity of insulin resistance, leading to recent investigations that stimulate BCAA metabolism for the potential benefit of metabolic diseases. BT2 (3,6-dichlorobenzo[b]thiophene-2-carboxylic acid), an inhibitor of branched-chain ketoacid dehydrogenase kinase, promotes BCAA metabolism by enhancing BCKDH complex activity
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Umbilical cord MSC-derived exosomes improve alveolar macrophage function and reduce LPS-induced acute lung injury J. Cell. Biochem. (IF 4.0) Pub Date : 2024-01-15 Enhai Cui, Lu Lv, Bin Wang, Liqin Li, Huadong Lu, Feng Hua, Wenyan Chen, Na Chen, Liwei Yang, Ruolang Pan
Acute lung injury (ALI) is a severe condition that can progress to acute respiratory distress syndrome (ARDS), with a high mortality rate. Currently, no specific and compelling drug treatment plan exists. Mesenchymal stem cells (MSCs) have shown promising results in preclinical and clinical studies as a potential treatment for ALI and other lung-related conditions due to their immunomodulatory properties
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Inhibition of receptor activator of nuclear factor kappa-B ligand-mediated osteoclast differentiation and bone resorption by Gryllus bimaculatus extract: An in vitro study J. Cell. Biochem. (IF 4.0) Pub Date : 2024-01-15 So Young Eun, Gyeong Do Park, Yoon-Hee Cheon, Myeung Su Lee, Hae Joong Cho, Ju-Young Kim
Excessive bone-resorbing osteoclast activity during bone remodeling is a major feature of bone diseases, such as osteoporosis. Therefore, the inhibition of osteoclast formation and bone resorption can be an effective therapeutic target for various bone diseases. Gryllus biomaculatus (GB) has recently been approved as an alternative food source because of its high nutritional value and environmental
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NAD+ supplementation prevents STING-induced senescence in CD8+ T cells by improving mitochondrial homeostasis J. Cell. Biochem. (IF 4.0) Pub Date : 2024-01-15 Bin Ye, Yingting Pei, Lujing Wang, Dehao Meng, Yu Zhang, Shuang Zou, Henian Li, Jinying Liu, Ziying Xie, Changhong Tian, Yuqi Jiang, Yu Qiao, Xu Gao, Yanfen Zhang, Ning Ma
Understanding the connection between senescence phenotypes and mitochondrial dysfunction is crucial in aging and premature aging diseases. Loss of mitochondrial function leads to a decline in T cell function, which plays a significant role in this process. However, more research is required to determine if improving mitochondrial homeostasis alleviates senescence phenotypes. Our research has shown
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The rational modulation of autophagy sensitizes colorectal cancer cells to 5-fluouracil and oxaliplatin J. Cell. Biochem. (IF 4.0) Pub Date : 2024-01-15 Andréa Baldasso-Zanon, Andrew Oliveira Silva, Nayara Franco, Rafael V. Picon, Guido Lenz, Patrícia Luciana da Costa Lopez, Eduardo C. Filippi-Chiela
Colorectal cancer (CRC) is the third most common and deadliest cancer globally. Regimens using 5-fluorouracil (5FU) and Oxaliplatin (OXA) are the first-line treatment for CRC, but tumor recurrence is frequent. It is plausible to hypothesize that differential cellular responses are triggered after treatments depending on the genetic background of CRC cells and that the rational modulation of cell tolerance
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Nonsynonymous mutations in VEGF receptor binding domain alter the efficacy of bevacizumab treatment J. Cell. Biochem. (IF 4.0) Pub Date : 2024-01-11 Ashif Ahamed, Arijit Samanta, Syed Sahajada Mahafujul Alam, Showkat Ahmad Mir, Zarnain Jamil, Safdar Ali, Mehboob Hoque
Vascular endothelial growth factor (VEGF) mediated angiogenesis is crucial for tumor progression. Isoforms of VEGF bind to different VEGF receptors (VEGFRs) to initiate angiogenesis specific cellular signaling. Inhibitors that target both the receptors and ligands are in clinical use to impede angiogenesis. Bevacizumab, a monoclonal antibody (mAb) approved by the Food and Drug Administration (FDA)
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Linc-ROR inhibits NK cell-killing activity by promoting RXRA ubiquitination and reducing MICB expression in gastric cancer patients J. Cell. Biochem. (IF 4.0) Pub Date : 2024-01-11 Qingbin Niu, Zongrui Li, He Jiang, Baoguang Hu
Linc-ROR plays an important role in gastric cancer (GC) development and progression. This study sought to determine how the aberrant expression of Linc-ROR impacts GC progression and immune evasion, and to identify new targets for GC therapy. GC cells overexpressing Linc-ROR and GSAGS cells were cocultured with NK-92 cells, respectively, and Linc-ROR expression was determined using reverse transcription
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Validating Fractalkine receptor as a target and identifying candidates for drug discovery against type 2 diabetes J. Cell. Biochem. (IF 4.0) Pub Date : 2023-12-19 Madhu Yadav, Yusuf Akhter
Type 2 diabetes mellitus (T2DM) is one of the most common chronic diseases employing abnormal levels of insulin. Enhancing the insulin production is greatly aided by the regulatory mechanisms of the Fractalkine receptor (CX3CR1) system in islet β-cell function. However, elements including a high-fat diet, obesity, and ageing negatively impact the expression of CX3CR1 in islets. CX3CL1/CX3CR1 receptor−ligand
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Circular RNA: A new expectation for cardiovascular diseases J. Cell. Biochem. (IF 4.0) Pub Date : 2023-12-14 Qiao Xie, Yun Ma, Zhong Ren, Tianhe Gu, Zhisheng Jiang
Circular RNA (circRNA) is a class of RNA with the 5' and 3' ends connected covalently to form a closed loop structure and characterized by high stability, conserved sequences and tissue specificity, which is caused by special reverse splicing methods. Currently, it has become a hot spot for research. With the discovery of its powerful regulatory functions and roles, the molecular mechanisms and future
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Intrinsic factors behind long COVID: III. Persistence of SARS-CoV-2 and its components J. Cell. Biochem. (IF 4.0) Pub Date : 2023-12-14 Nawal Abd El-Baky, Amro A. Amara, Vladimir N. Uversky, Elrashdy M. Redwan
Considerable research has been done in investigating SARS-CoV-2 infection, its characteristics, and host immune response. However, debate is still ongoing over the emergence of post-acute sequelae of SARS-CoV-2 infection (PASC). A multitude of long-lasting symptoms have been reported several weeks after the primary acute SARS-CoV-2 infection that resemble several other viral infections. Thousands of
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Asperosaponin VI facilitates the regeneration of skeletal muscle injury by suppressing GSK-3β-mediated cell apoptosis J. Cell. Biochem. (IF 4.0) Pub Date : 2023-12-11 Xinru Yang, Jian Liang, Yue Shu, Linlin Wei, Cailing Wen, Hui Luo, Liqing Ma, Tian Qin, Bin Wang, Siyu Zeng, Ying Liu, Chun Zhou
Asperosaponin VI (ASA VI) is a bioactive triterpenoid saponin extracted from Diptychus roots, of Diptyl, and has previously shown protective functions in rheumatoid arthritis and sepsis. This study investigates the effects and molecular mechanisms of ASA VI on skeletal muscle regeneration in a cardiotoxin (CTX)-induced skeletal muscle injury mouse model. Mice were subjected to CTX-induced injury in
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Novel mutation in EFEMP1 identified from two Chinese POAG families differentially activated endoplasmic reticulum stress markers and induced glaucoma in mouse J. Cell. Biochem. (IF 4.0) Pub Date : 2023-12-11 Xiaoqiang Xiao, Chong-Bo Chen, Zhenggen Wu, Yuhang Ye, Fang Deng, Yingjie Cao, Pingting Liu, Mingzhi Zhang
Primary open-angle glaucoma (POAG) is the most common type of glaucoma. Using whole-exome sequencing, we identified two independent families diagnosed as POAG from the China with a novel EFEMP1 variant (Exon3, c.175A>C p.Met59Leu); Three previously reported variants c.1160G>A p.R387Q, c.1189T>C p.Y397H, and c.1429C>T p.R477C in EFEPM1 from 55 sporadic POAG individuals were also identified. The variant