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Effects of nucleoside analogues, lipophilic prodrugs and elaidic acids on core signaling pathways in cancer cells Nucleosides Nucleotides Nucleic Acids (IF 1.3) Pub Date : 2024-04-15 Marika A. Frańczak, Claudine van der Sande, Elisa Giovannetti, Godefridus J. Peters
Nucleoside analogs such as gemcitabine (GEM; dFdC) and cytarabine (Ara-C) require nucleoside transporters to enter cells, and deficiency in equilibrative nucleoside transporter 1 (ENT1) can lead to...
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Correlation of BARD1 gene polymorphisms with risk of neuroblastoma: a meta-analysis Nucleosides Nucleotides Nucleic Acids (IF 1.3) Pub Date : 2024-04-15 Shan Chen, Di Xu, Rongdong Huang, Yang Lin, Lizhi Li
BRCA1-associated RING domain protein 1 (BARD1) gene polymorphisms may be associated with neuroblastoma (NB) susceptibility. However, the results remain controversial. Relevant studies were identifi...
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Promoter of lncRNA MORT is aberrantly methylated in colorectal cancer Nucleosides Nucleotides Nucleic Acids (IF 1.3) Pub Date : 2024-04-15 Aylar Nazari, Tayyebeh Ghasemi, Mohammad Khalaj-Kondori, Ramin Fathi
Aberrant DNA methylation plays essential roles in the colorectal cancer (CRC) carcinogenesis and has been demonstrated as a promising marker for cancer early detection. In this project, methylation...
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Association of rs11081062 polymorphism of DLGAP1 gene and levels of SLC1A1 protein with obsessive-compulsive disorder Nucleosides Nucleotides Nucleic Acids (IF 1.3) Pub Date : 2024-04-09 Efruz İrem Akkuş, Burcu Bayoğlu, Neşe Kocabaşoğlu, Jansed Berfin Yıldız, Müjgan Cengiz
Glutamate is an important neurotransmitter known to be effective in obsessive-compulsive disorder (OCD). The aim of this study is to investigate the relationship between the DLGAP1 gene encoding th...
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Evaluation of miR-130b-3p and miR-375 levels and telomere length with telomerase activity in prostate cancer Nucleosides Nucleotides Nucleic Acids (IF 1.3) Pub Date : 2024-04-09 Abdullah Karadağ, Ebubekir Dirican, Çağdaş Gökhun Özmerdiven, Ata Özen, Semih Ayan, Selda Kabadere
Prostate cancer (PC) is the most frequent cancer in males, as well as the second highest cause of cancer-related deaths in men. Differences in expression levels of miRNAs were linked with prostat c...
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Construction of a novel mRNA–miRNA–lncRNA/circRNA triple subnetwork associated with immunity and aging in intervertebral disc degeneration Nucleosides Nucleotides Nucleic Acids (IF 1.3) Pub Date : 2024-03-31 Wei Liu, Hui-Min Li, Guangchao Bai
Intervertebral disk degeneration (IVDD) is one of the most common causes of low back pain. However, in the etiology of IVDD, the specific method by which nucleus pulposus (NP) cell senescence and t...
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Bioinformatics and meta-analysis of the clinical significance of RECK expression and its genetic polymorphisms in cancer Nucleosides Nucleotides Nucleic Acids (IF 1.3) Pub Date : 2024-04-01 Weichao Zhang, Xueren Gao
RECK plays an important role in the development of cancer. The current study focuses on exploring the clinical significance of RECK expression in cancer by mining public data and also evaluating th...
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The relationship between polymorphism of IGF2BP2 gene rs4402960 and risk of pan-cancer: a meta-analysis and a bioinformatics analysis Nucleosides Nucleotides Nucleic Acids (IF 1.3) Pub Date : 2024-03-31 Fengke Lu, Gan Gao, Hongyu Zhang, Wei Zhang
To conduct a meta-analysis and a bioinformatics analysis to assess the relationship between IGF2BP2 gene polymorphism and pan-cancer risk.PubMed, EMBASE, and Web of Science were conducted to litera...
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Anticancer sensitivity and biological aspect of 5-fluorouracil-resistant human colorectal cancer HCT116 cells in three-dimensional culture under high- and low-glucose conditions Nucleosides Nucleotides Nucleic Acids (IF 1.3) Pub Date : 2024-03-31 Chinatsu Kurasaka, Nana Nishizawa, Yoko Ogino, Akira Sato
5-Fluorouracil (5-FU) is a commonly used anticancer drug for colorectal cancer (CRC). Therefore, it is crucial to elucidate the mechanisms that contribute to 5-FU resistance. We established an acqu...
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Synthesis, antimicrobial, and in silico studies of c5′-O-substituted cytidine derivatives: cinnamoylation leads to improvement of antimicrobial activity Nucleosides Nucleotides Nucleic Acids (IF 1.3) Pub Date : 2024-03-28 Tahmida Sultana Bhuiyan, Mohamed A. Said, Md Z. H. Bulbul, Sumeer Ahmed, Ajmal R. Bhat, Mohammed Chalkha, Sarkar M. A. Kawsar
Nucleoside derivatives are important therapeutic drugs that have drawn significant attention recently. In this study, cytidine (1) was first exposed to react with cinnamoyl chloride in N,N-dimethyl...
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Integrated bioinformatics analysis of ferroptosis-related gene signature in inflammation and immunity in intervertebral disc degeneration Nucleosides Nucleotides Nucleic Acids (IF 1.3) Pub Date : 2024-03-26 Wei Liu, Hui-Min Li, Guangchao Bai
Ferroptosis has recently been shown to play a significant role in the progression of intervertebral disk degeneration (IDD), although the underlying mechanism is still unknown. The objective of thi...
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The role of miRNA134 in pathogenesis and treatment of intractable epilepsy: a review article Nucleosides Nucleotides Nucleic Acids (IF 1.3) Pub Date : 2024-03-26 Maniya Kasaiyan, Mohsen Basiri, Sara Pajouhanfar
MicroRNA-134 (miRNA134) has emerged as a critical regulator in the pathogenesis of epilepsy, particularly in intractable cases resistant to conventional therapies. This review explores the multifac...
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The critical role and functional mechanism of microRNA-146a in doxorubicin-induced apoptosis in breast cancer cells Nucleosides Nucleotides Nucleic Acids (IF 1.3) Pub Date : 2024-03-26 Sara Tutunchi, Parisa Nourmohammadi, Roghayeh Tofigh, Saeedeh Akhavan, Mina Zare, Sadra Samavarchi Tehrani, Ghodratollah Panahi
Breast cancer among women is the most frequently diagnosed cancer and the leading cause of death worldwide. There many advances in diagnosing and treating this disease, early diagnosis and treatmen...
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Molecular characterization of Drosophila melanogaster thymidylate kinase Nucleosides Nucleotides Nucleic Acids (IF 1.3) Pub Date : 2024-03-22 Junmei Hu Frisk, Liya Wang
Drosophila has been used as an animal model to study pathogenic mechanism of neurological disorders. Thymidylate kinase (TMPK) is an essential enzyme in dTTP synthesis catalyzing the phosphorylatio...
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Association of the polymorphisms rs179008 (TLR7), rs2004640 (IRF5), rs1800795 (IL-6) and rs2280788 (CCL5) with systemic lupus erythematosus in women of Mayan ethnicity from Yucatan Nucleosides Nucleotides Nucleic Acids (IF 1.3) Pub Date : 2024-03-08 Yumi Elena Nakazawa-Ueji, Guillermo Valencia-Pacheco, Lizbeth Josefina González-Herrera, Laureano Chan-Chalé, Rubí Misol-Ha Velasco-Cárdenas, Martha Julia Carreño-Gonzalez, Gerardo Pérez-Mendoza, Guadalupe Isabel Amaro-Adrián, Edwin Arturo Rodríguez-Dzul, Irma Guadalupe Quintal-Ortiz, Angélica Vanesa Angulo-Ramírez, Ricardo Francisco López-Villanueva
Introduction: IFN-α is the main cytokine in SLE, and single nucleotide polymorphisms (SNP) in different genes could induce it. Aim: To determine the association of rs2004640 (IRF5), rs179008 (TLR7)...
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DNA three-way junction structures with amino acid side chains prepared via post-synthetic amide condensation Nucleosides Nucleotides Nucleic Acids (IF 1.3) Pub Date : 2024-02-15 Yusuke Takezawa, Naofumi Kudo, Nobuyuki Fuse, Mitsuhiko Shionoya
DNA three-way junction (3WJ) structures with three amino acid side chains in the core have been synthesized via post-synthetic DNA modification. Amide condensation reactions of oligonucleotides con...
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Evaluation and normalization of a set of reliable reference genes for quantitative sgk-1 gene expression analysis in Caenorhabditis elegans-focused cancer research Nucleosides Nucleotides Nucleic Acids (IF 1.3) Pub Date : 2024-02-15 Özgür Ülkü Özdemir, Kübra Yurt, Ayşe Nur Pektaş, Şeyda Berk
Multiple signaling pathways have been discovered to play a role in aging and longevity, including the insulin/IGF-1 signaling system, AMPK pathway, TOR signaling, JNK pathway, and germline signalin...
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Investigation of the relationship between ACAN gene VNTR polymorphism and Alzheimer’s disease in Turkish population Nucleosides Nucleotides Nucleic Acids (IF 1.3) Pub Date : 2024-02-10 Tugba Keskin, Orcun Avsar, Sinan Eliacik, Funda Uysal Tan
Alzheimer’s disease is one of the most common causes of dementia and is a neurodegenerative disease that occurs with memory loss, loss of language, thinking and problem-solving skills. In this stud...
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Cancer stem cells: Recent trends in cancer therapy Nucleosides Nucleotides Nucleic Acids (IF 1.3) Pub Date : 2024-02-06 Maryam Amiri-Farsani, Zahra Taheri, Somayeh Tirbakhsh Gouran, Omid Chabok, Maryam Safarpour-Dehkordi, Mahsa Kazemi Roudsari
Cancer stem cells (CSCs) are a subset of tumor cells that were first identified in blood cancers (leukemia) and are considered promising therapeutic targets in cancer treatment. These cells are the...
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Tuberculosis and lung cancer: metabolic pathways play a key role Nucleosides Nucleotides Nucleic Acids (IF 1.3) Pub Date : 2024-02-02 Kianoosh Ferdosnejad, Mohammad Saber Zamani, Erfan Soroush, Abolfazl Fateh, Seyed Davar Siadat, Samira Tarashi
Despite the fact that some cases of tuberculosis (TB) are undiagnosed and untreated, it remains a serious global public health issue. In the diagnosis, treatment, and control of latent and active T...
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Naphthyl cyanoketene N,S-acetals in glycoside synthesis: a new preparative route to a new class of N-naphthylcyanoacrylamide thioglycosides and their conversions to naphthyl–pyrazole hybrids Nucleosides Nucleotides Nucleic Acids (IF 1.3) Pub Date : 2024-01-24 Galal H. Elgemeie, Nahed M. Fathy, Sayed I. Shaarawi
The novel N-naphthylcyanoacrylamide thioglycosides 4 were readily prepared by the reaction of N-napthylcyanoacetamide 1 with aryl isothiocyanates in the presence of potassium hydroxide, followed by...
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Comparison of interaction between antimiR and microRNA versus HDO-antimiR and microRNA by molecular dynamics simulation Nucleosides Nucleotides Nucleic Acids (IF 1.3) Pub Date : 2024-01-11 Kazutaka Nishina, Kotaro Yoshioka, Takanori Yokota, Rintaro Iwata Hara
Recently, we found DNA/RNA heteroduplex oligonucleotide-based antimiR (HDO-antimiR) can more efficiently inhibit the target miRNA than conventional antimiR after its cellular uptake. But the mechan...
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Integrative bioinformatics analysis reveals ECM and nicotine-related genes in both LUAD and LUSC, but different lung fibrosis-related genes are involved in LUAD and LUSC Nucleosides Nucleotides Nucleic Acids (IF 1.3) Pub Date : 2024-01-10 Marzyeh Alipour, Mehdi Moghanibashi, Sirous Naeimi, Parisa Mohamadynejad
There are several bioinformatics studies related to lung cancer, but most of them have mainly focused on either microarray data or RNA-Seq data alone. In this study, we have combined both types of ...
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Clinical significance of BTLA gene expression and rs1982809 polymorphism in pan-cancer Nucleosides Nucleotides Nucleic Acids (IF 1.3) Pub Date : 2023-12-20 Xueren Gao, Yichang Gao, Shiyu Pan, Lin Yang
The association between the B and T lymphocyte attenuator (BTLA) gene rs1982809 polymorphism and cancer susceptibility has been reported, but these findings are inconsistent. In addition to clarify...
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Identification of common genes and pathways underlying imatinib and nilotinib treatment in CML: a Bioinformatics Study Nucleosides Nucleotides Nucleic Acids (IF 1.3) Pub Date : 2023-12-20 Yalda Hekmatshoar, Yalda Rahbar Saadat, Tulin Ozkan, Sureyya Bozkurt, Aynur Karadag Gurel
Imatinib (IMA) and nilotinib are the first and second generations of BCR-ABL tyrosine kinase inhibitors, which widely applied in chronic myeloid leukemia (CML) treatment. Here we aimed to provide n...
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“Difficult” deoxyribonucleotide sequences in the solid-phase synthesis by the phosphoramidite chemistry Nucleosides Nucleotides Nucleic Acids (IF 1.3) Pub Date : 2023-12-20 Quanjian Li, Hongbin Yan
This work catalogued oligonucleotide sequences and sequence compositions based on the overall yield of full-length product obtained by the phosphoramidite chemistry-based solid phase synthesis. In ...
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Synthesis of novel 5-[3-(4-chlorophenyl)-substituted-1,3-dimethylpyrimidine-2,4,6(1H,3H,5H)-trione derivatives as potential anti-diabetic and anticancer agents Nucleosides Nucleotides Nucleic Acids (IF 1.3) Pub Date : 2023-12-06 S. H. Sukanya, Talavara Venkatesh, H. Shanavaz
In this work, we developed a series of novel 5-[3-(4-chlorophenyl)-substituted-1,3-dimethylpyrimidine-2,4,6(1H,3H,5H)-trione derivatives 4(a-e) via a one-pot multicomponent reaction. The structures...
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Characterization of serum extracellular vesicles and their differential level of miR-197-3p in familial Mediterranean fever patients Nucleosides Nucleotides Nucleic Acids (IF 1.3) Pub Date : 2023-12-02 Zeynep Tavukcuoglu, Yeliz Z. Akkaya-Ulum, Nilgun Yersal, Utku Horzum, Tayfun Hilmi Akbaba, Omer Karadag, Gunes Esendagli, Petek Korkusuz, Seza Ozen, Banu Balci-Peynircioglu
The aim of this study was to analyze the existence of miRNAs derived from serum extracellular vesicles (EVs) in familial Mediterranean fever (FMF) patients. Our group has previously shown the assoc...
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Algal organic matter induced photodegradation of tinidazole Nucleosides Nucleotides Nucleic Acids (IF 1.3) Pub Date : 2023-12-01 Waseem Ahmad, Nikky Kaur, Amit Parashar
Antibiotic pollution has become one of the most emerging problems of the modern era. Tinidazole (TDZ) is one the most important nitroimidazole derivative drugs whose use has tremendously increased ...
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Investigation of circadian rhythm gene Per3 in diabetic neuropathy Nucleosides Nucleotides Nucleic Acids (IF 1.3) Pub Date : 2023-12-01 Hüsniye Rüstemoğlu, Recai Aci, Süheyla Uzun, Serbülent Yiğit, Aydın Rüstemoğlu
Diabetic neuropathy (DN) is a serious complication of diabetes that affects peripheral and autonomic nerves, and it has been linked to irregularities in circadian rhythm. Several studies have demon...
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Lack of association between VNTR variant of the circadian gene (PER3) and major depressive disorder in a sample of a Turkish population Nucleosides Nucleotides Nucleic Acids (IF 1.3) Pub Date : 2023-11-24 Serbulent Yigit, Ayse Feyda Nursal, Filiz Ozsoy, Esra Duman, Melih Sercan Ustaoglu
Major depressive disorder (MDD), which is a prevalent psychiatric disorder, is characterized by sleep-wake disturbances. An underlying circadian rhythm disorder mainly may cause these disturbances....
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Association between genetic variants of GRM7 (rs1396409 and rs9883258) and treatment outcomes in Schizophrenic Egyptian patients Nucleosides Nucleotides Nucleic Acids (IF 1.3) Pub Date : 2023-11-24 Abeer A. Alrefai, Ahmed N. Ramadan, Marwa M. Omar, Yasser Abdelsattar Elghobashy, Shimaa E. Soliman
This study evaluated the association between rs1396409 and rs9883258 and the risk of schizophrenia (SCZ) and treatment outcomes in Egyptian patients.This study included 88 patients with SCZ and 88 ...
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VEGF I/D variant and preeclampsia risk in Turkish women: a case-control study Nucleosides Nucleotides Nucleic Acids (IF 1.3) Pub Date : 2023-11-22 Mehmet Can Nacar, Serbulent Yigit, Adem Keskin, Pinar Kirici, Talip Karacor
Preeclampsia (PE) is a systemic vascular disorder, is caused by an imbalance of pro- and anti-angiogenic factors that directly affect endothelial function. Vascular endothelial growth factor A (cal...
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The effect of HLA-DP gene polymorphisms in Plasmodium Vivax-induced malaria susceptibility Nucleosides Nucleotides Nucleic Acids (IF 1.3) Pub Date : 2023-11-19 Ersin Akgöllü, Mehtap Demirkazık, Ramazan Bilgin
Plasmodium vivax is the second most common Plasmodium parasite causing clinically serious symptoms and death from malaria. It is an important cause of morbidity and mortality, especially in Asia, t...
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Development of low-cost in-house tetra-ARMS-PCR assay for the screening of five CBS mutations found in Pakistani homocystinuria patients Nucleosides Nucleotides Nucleic Acids (IF 1.3) Pub Date : 2023-11-16 Adila Khalil, Haq Nawaz Khan, Muhammad Wasim, Hina Ayesha, Fazli Rabbi Awan
Classical homocystinuria is an inborn amino acid metabolism disorder resulting from mutations in the Cystathionine-β-Synthase (CBS) gene. These mutations lead to elevated homocysteine and methionin...
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Interaction studies of water-soluble Zn(II) complex with calf thymus DNA using biophysical and molecular docking methods Nucleosides Nucleotides Nucleic Acids (IF 1.3) Pub Date : 2023-11-14 Nahid Shahabadi, Lida Ghaffari, Zahra Mardani, Farshad Shiri
The binding between a fluorescent water-soluble Zn(II) complex of {2-[N-(2-hydroxyethylammonioethyl) imino methyl] phenol} and calf thymus DNA (ct-DNA) was investigated using spectroscopic techniqu...
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Types of DNA damage and research progress Nucleosides Nucleotides Nucleic Acids (IF 1.3) Pub Date : 2023-11-10 Liu Nian, Li Xiaohua, Li Rongcheng, Liu Song-Bai
DNA damage is a modification in the structure of DNA under the influence of endogenous or exogenous factors. DNA damage can cause different types of diseases and is closely related to genetic mutat...
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Association between interferon-gamma (IFN-γ) gene polymorphisms and tuberculosis susceptibility: a systematic review and meta-analysis Nucleosides Nucleotides Nucleic Acids (IF 1.3) Pub Date : 2023-10-24 Xu Hu, Xiaoying Lu
Interferon-gamma (IFN-γ) has been established to play a pivotal role in the pathogenesis of tuberculosis (TB). Existing evidence suggests a potential association between the genetic polymorphisms ...
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Looking for the unexpected in purine and pyrimidine metabolism Nucleosides Nucleotides Nucleic Acids (IF 1.3) Pub Date : 2023-10-24 Lars Petter Jordheim, Caius G. Radu, Godefridus J. Peters
In June 2023, the Purine and Pyrimidine Society (PPS) organized the 20th biennial symposium on Purine and Pyrimidine metabolism (PP23). The symposium was organized in Los Angeles, California, USA, ...
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Clinical use of biomarkers in the field of cytotoxic nucleoside analogues Nucleosides Nucleotides Nucleic Acids (IF 1.3) Pub Date : 2023-10-24 Lars Petter Jordheim
Cytotoxic nucleosides (gemcitabine, cytarabine…) are used for the treatment of various malignancies. Their activity is dependent on the interaction with several proteins and enzymes of nucleotide m...
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6-azido and 6-azidomethyl uracil nucleosides Nucleosides Nucleotides Nucleic Acids (IF 1.3) Pub Date : 2023-10-19 Yahaira Reyes, Alexander Mebel, Stanislaw F. Wnuk
Azido nucleosides have been utilized for click reactions, metabolic incorporation into cellular DNA, and fluorescent imaging of live cells. Two classes of 6-azido modified uracil nucleosides; one w...
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IL2RA rs2104286 and IL2 rs2069762 polymorphisms may be associated with bipolar disorder and its clinical findings Nucleosides Nucleotides Nucleic Acids (IF 1.3) Pub Date : 2023-10-16 Sacide Pehlivan, Hasan Mervan Aytac, Ayse Feyda Nursal, Fatima Ceren Tuncel, Mustafa Pehlivan
Study results supported that immuno-inflammatory pathways in the brain and environment contribute to the etiopathogenesis of bipolar disorder (BD), a chronic affective disease. Our study aimed to a...
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IL2RA rs2104286 and IL2 rs2069762 polymorphisms may be associated with bipolar disorder and its clinical findings Nucleosides Nucleotides Nucleic Acids (IF 1.3) Pub Date : 2023-10-16 Sacide Pehlivan, Hasan Mervan Aytac, Ayse Feyda Nursal, Fatima Ceren Tuncel, Mustafa Pehlivan
Study results supported that immuno-inflammatory pathways in the brain and environment contribute to the etiopathogenesis of bipolar disorder (BD), a chronic affective disease. Our study aimed to a...
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Association of fatty acid binding protein-4 (FABP-4) T87C and rs8192688 gene polymorphisms and FABP-4 level with cardiovascular disease susceptibility in type 2 diabetic patients Nucleosides Nucleotides Nucleic Acids (IF 1.3) Pub Date : 2023-10-09 Amin Bakhtiyari, Salar Bakhtiyari, Maryam Peymani, Karimeh Haghani, Siros Norozi
Type 2 Diabetes Mellitus (T2DM) is known to cause dyslipidemia and increase the risk of cardiovascular disease (CVD). Fatty acid binding protein (FABP)-4 plays a significant role in various stages ...
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Association of fatty acid binding protein-4 (FABP-4) T87C and rs8192688 gene polymorphisms and FABP-4 level with cardiovascular disease susceptibility in type 2 diabetic patients Nucleosides Nucleotides Nucleic Acids (IF 1.3) Pub Date : 2023-10-09 Amin Bakhtiyari, Salar Bakhtiyari, Maryam Peymani, Karimeh Haghani, Siros Norozi
Type 2 Diabetes Mellitus (T2DM) is known to cause dyslipidemia and increase the risk of cardiovascular disease (CVD). Fatty acid binding protein (FABP)-4 plays a significant role in various stages ...
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Identification of autophagy and angiogenesis modulators in colorectal cancer based on bioinformatics analysis Nucleosides Nucleotides Nucleic Acids (IF 1.3) Pub Date : 2023-10-04 Fariba Shakeri, Parisa Mohamadynejad, Mehdi Moghanibashi
Colorectal cancer (CRC) is the third most common cancer and the fourth leading cause of cancer-related death worldwide. The purpose of this study was to discover novel molecular pathways and potent...
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The evaluation of the possibility of Li-Fraumeni syndrome in cancer patients in East Azarbaijan Province of Iran Nucleosides Nucleotides Nucleic Acids (IF 1.3) Pub Date : 2023-10-06 Maryam Esmaeilzadeh Aghjeh, Mohammad Ali Hosseinpour Feizi, Reza Safaralizadeh, Abbas Ali Hosseinpour Feizi, Nasser Pouladi
Introduction: In 1969, Li-Fraumeni syndrome (LFS), which is a rare cancer predisposition syndrome, was reported for the first time. The main problem in LFS is the mutation in the TP53 gene, which i...
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The evaluation of the possibility of Li-Fraumeni syndrome in cancer patients in East Azarbaijan Province of Iran Nucleosides Nucleotides Nucleic Acids (IF 1.3) Pub Date : 2023-10-06 Maryam Esmaeilzadeh Aghjeh, Mohammad Ali Hosseinpour Feizi, Reza Safaralizadeh, Abbas Ali Hosseinpour Feizi, Nasser Pouladi
Introduction: In 1969, Li-Fraumeni syndrome (LFS), which is a rare cancer predisposition syndrome, was reported for the first time. The main problem in LFS is the mutation in the TP53 gene, which i...
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Expression of GRP78 and its copartners in HEK293 and pancreatic cancer cell lines (BxPC-3/PANC-1) exposed to MRI and CT contrast agents Nucleosides Nucleotides Nucleic Acids (IF 1.3) Pub Date : 2023-10-03 Ali Ahmed Azzawri, Ibrahim Halil Yildirim, Zeynep Yegin, Abdurrahim Dusak
Endoplasmic reticulum (ER) stress-associated chaperones trigger a defense mechanism called as unfolded protein response (UPR) which can manage apoptosis and be determinative in cell fate. Both anti...
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Identification of the effects of pathogenic genetic variations of human CYP2C9 and CYP2D6: an in silico approach Nucleosides Nucleotides Nucleic Acids (IF 1.3) Pub Date : 2023-09-25 Orcun Avsar
Genetic variations in the human cytochrome P450 family 2 subfamily C member 9 (CYP2C9) and cytochrome P450 family 2 subfamily D member 6 (CYP2D6) genes may affect drug metabolism and lead to altera...
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Light-regulated RNA interference induced by p-hydroxyphenacyl-modified siRNA in mammalian cells Nucleosides Nucleotides Nucleic Acids (IF 1.3) Pub Date : 2023-09-13 Swati Arora, Chengde Mao
Abstract siRNA is an important tool for modulating gene expression in current biomedical research. It would be highly desirable for siRNA to respond to an external stimulus. In this paper, we report a convenient, photolabile caging agent to regulate siRNA functions. 2-bromo-4’-hydroxyacetophenone (BHAP) can readily modify phosphorothioate backbones and inhibit siRNAs. Mild UV irradiation will cleave
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Elevated programmed cell death-1 protein/ligand (PD-1/PD-L1) and variants are associated with susceptibility to multiple myeloma: a case-control study in the Chinese cohort Nucleosides Nucleotides Nucleic Acids (IF 1.3) Pub Date : 2023-09-09 Jing Yang, Ling Meng, Yongxin Yang, Hongwei Gao, Honggang Jiang
Multiple myeloma (MM) is a malignant disorder characterised by progressive immune dysregulation. The importance of programmed cell death protein 1 (PD-1)/programmed cell death ligand 1 (PD-L1) in M...
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Investigation of MIF gene promoter variations and their haplotypes in the Alzheimer disease in Turkish population Nucleosides Nucleotides Nucleic Acids (IF 1.3) Pub Date : 2023-09-04 Kubra Sahin, Aydın Rustemoglu
Abstract In Alzheimer’s disease, which is characterized by amyloid plaques and neurofibrillary tangles in the brain tissue, many components such as acute phase proteins, cytokines, and proteases contribute to the progression of the disease or are part of the pathological process. The macrophage migration inhibitory factor (MIF) gene encodes a cytokine, which is secreted by lymphocytes, and has a role
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Investigation of virulence factors in Pseudomonas aeruginosa isolates by phenotypic and genotypic methods Nucleosides Nucleotides Nucleic Acids (IF 1.3) Pub Date : 2023-09-04 Erhan Özsoy, Umut Safiye Şay Coşkun, Yelda Dagcıoğlu, Osman Demir
Abstract Introduction Pseudomonas aeruginosa possesses a variety of virulence factors that may contribute to its pathogenicity, and relationship has been determined between antibiotic resistance and biofilm. The aim of this study was to investigate the virulence factors of Pseudomonas aeruginosa isolates by genotypic and phenotypic methods, as well as whether there is a relationship between other virulence
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SALL4 advances the proliferation and tumor cell stemness of colon cancer cells through the transcription and regulation of ROBO2 Nucleosides Nucleotides Nucleic Acids (IF 1.3) Pub Date : 2023-09-03 Yahui Jiang, Yunhao Tang
Abstract SALL4 is a transcription factor highly expressed in diverse cancers and is implicated in the development of cancer. SALL4 has been implied to play a cancer-promoting role in colon cancer (CC), but the molecular mechanism remains unclear. Chromatin immunoprecipitation assay and dual-luciferase assay were conducted to verify the binding relationship of SALL4 and ROBO2. qRT-PCR detected the mRNA
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SALL4 advances the proliferation and tumor cell stemness of colon cancer cells through the transcription and regulation of ROBO2 Nucleosides Nucleotides Nucleic Acids (IF 1.3) Pub Date : 2023-09-03 Yahui Jiang, Yunhao Tang
SALL4 is a transcription factor highly expressed in diverse cancers and is implicated in the development of cancer. SALL4 has been implied to play a cancer-promoting role in colon cancer (CC), but ...
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Effect of vitamin D receptor gene BsmI polymorphism on hospitalization of SARS-CoV-2 positive patients Nucleosides Nucleotides Nucleic Acids (IF 1.3) Pub Date : 2023-08-30 Recai Aci, Adem Keskin, Serbulent Yigit, Ozlem Sezer, Muhammet Taha Kaya
Abstract Low vitamin D levels and adverse effects have been reported in SARS-COV-2 positive patients. This study examined the effect of the vitamin D receptor gene BsmI polymorphism on SARS-COV-2 positive patients. A total of 80 SARS-COV-2 positive inpatients were included in the study, and 110 healthy individuals were included as a control group. The 25-(OH) vitamin D3, lymphocyte, and activated partial
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Effect of vitamin D receptor gene BsmI polymorphism on hospitalization of SARS-CoV-2 positive patients Nucleosides Nucleotides Nucleic Acids (IF 1.3) Pub Date : 2023-08-30 Recai Aci, Adem Keskin, Serbulent Yigit, Ozlem Sezer, Muhammet Taha Kaya
Low vitamin D levels and adverse effects have been reported in SARS-COV-2 positive patients. This study examined the effect of the vitamin D receptor gene BsmI polymorphism on SARS-COV-2 positive p...
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Different expression of DACT1, DACT2, and CYCLIN D1 genes in human colorectal cancer tissues and its association with clinicopathological characteristics Nucleosides Nucleotides Nucleic Acids (IF 1.3) Pub Date : 2023-08-23 Majid Ghasemian, Masoumeh Rajabibazl, Jafar Poodineh, Hossein Sadeghi, Amirnader Emami Razavi, Reza Mirfakhraie
Abstract Aberrant activation of Wnt pathway is linked to dysregulation of several genes. DACT1 and DACT2 are members of the DACT family that participate in antagonizing of the Wnt signaling cascade. Thus in this study, we assessed the mRNA levels of DACT1, DACT2, and CYCLIN D1 in 70 pairs of CRC tissues compared to the adjacent tissues. Determination of the mRNA levels of DACT1, DACT2, and CYCLIN D1
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Association of common variants of TCF7L2 and PCSK2 with gestational diabetes mellitus in West Bengal, India Nucleosides Nucleotides Nucleic Acids (IF 1.3) Pub Date : 2023-08-23 Jayita Basu, Ruchira Mukherjee, Pooja Sahu, Chhanda Datta, Subhankar Chowdhury, Debasmita Mandal, Amlan Ghosh
Abstract The genetic etiology of gestational diabetes mellitus (GDM) was suggested to overlap with type-2 diabetes(T2D). Transcription factor 7-like 2 (TCF7L2) and Proprotein Convertase Subtilisin/Kexin type 2 (PCSK2) are T2D susceptibility genes of the insulin synthesis/processing pathway. We analyzed associations of TCF7L2 and PCSK2 variants with GDM risk and evaluated their potential impact on impaired