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Retraction: miR‐655 suppresses epithelial‐to‐mesenchymal transition by targeting Prrx1 in triple‐negative breast cancer J. Cell. Mol. Med. (IF 5.3) Pub Date : 2024-04-24
Zhi‐Dong Lv, Bin Kong, Xiang‐Ping Liu, Li‐Ying Jin, Qian Dong, Fu‐Nian Li, Hai‐Bo Wang, miR‐655 suppresses epithelial‐to‐mesenchymal transition by targeting Prrx1 in triple‐negative breast cancer. Journal of Cellular and Molecular Medicine, 20: 864–873. https://doi.org/10.1111/jcmm.12770The above article, published online on 28 January 2016 in Wiley Online Library (wileyonlinelibrary.com), has been
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Rapid discrimination of four Salmonella enterica serovars: A performance comparison between benchtop and handheld Raman spectrometers J. Cell. Mol. Med. (IF 5.3) Pub Date : 2024-04-23 Quan Yuan, Bin Gu, Wei Liu, Xin‐Ru Wen, Ji‐Liang Wang, Jia‐Wei Tang, Muhammad Usman, Su‐Ling Liu, Yu‐Rong Tang, Liang Wang
Foodborne illnesses, particularly those caused by Salmonella enterica with its extensive array of over 2600 serovars, present a significant public health challenge. Therefore, prompt and precise identification of S. enterica serovars is essential for clinical relevance, which facilitates the understanding of S. enterica transmission routes and the determination of outbreak sources. Classical serotyping
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Interplay of precision therapeutics and MD study: Calocybe indica's potentials against cervical cancer and its interaction with VEGF via octadecanoic acid J. Cell. Mol. Med. (IF 5.3) Pub Date : 2024-04-23 Suhana Datta, Preeti Verma, Bikram Dhara, Rita Kundu, Swastika Maitra, Arup Kumar Mitra, Mohd Shahnawaz Khan, Torki A. Zughaibi, Shams Tabrez, Ajoy Kumer
The evolving landscape of personalized medicine necessitates a shift from traditional therapeutic interventions towards precision‐driven approaches. Embracing this paradigm, our research probes the therapeutic efficacy of the aqueous crude extract (ACE) of Calocybe indica in cervical cancer treatment, merging botanical insights with advanced molecular research. We observed that ACE exerts significant
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The β3‐AR agonist BRL37344 ameliorates the main symptoms of X‐linked nephrogenic diabetes insipidus in the mouse model of the disease J. Cell. Mol. Med. (IF 5.3) Pub Date : 2024-04-23 Serena Milano, Ilenia Saponara, Andrea Gerbino, Monica Carmosino, Maria Svelto, Giuseppe Procino
X‐linked nephrogenic diabetes insipidus (X‐NDI) is a rare congenital disease caused by inactivating mutations of the vasopressin type‐2 receptor (AVPR2), characterized by impaired renal concentrating ability, dramatic polyuria, polydipsia and risk of dehydration. The disease, which still lacks a cure, could benefit from the pharmacologic stimulation of other GPCRs, activating the cAMP‐intracellular
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Retraction: Tanshinone IIA alleviates lipopolysaccharide‐induced acute lung injury by downregulating TRPM7 and pro‐inflammatory factors J. Cell. Mol. Med. (IF 5.3) Pub Date : 2024-04-23
Jie Li, Yan Zheng, Ming‐Xian Li, Chu‐Wei Yang, Yu‐Fei Liu, Tanshinone IIA alleviates lipopolysaccharide‐induced acute lung injury by downregulating TRPM7 and pro‐inflammatory factors. Journal of Cellular and Molecular Medicine, 22: 646–654. https://doi.org/10.1111/jcmm.13350The above article, published online on 18 October 2017 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by
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Bortezomib suppresses acute myelogenous leukaemia stem‐like KG‐1a cells via NF‐κB inhibition and the induction of oxidative stress J. Cell. Mol. Med. (IF 5.3) Pub Date : 2024-04-23 Rafaela G. A. Costa, Maiara de S. Oliveira, Ana Carolina B. da C. Rodrigues, Suellen L. R. Silva, Ingrid R. S. B. Dias, Milena B. P. Soares, Ludmila de Faro Valverde, Clarissa Araujo Gurgel Rocha, Rosane Borges Dias, Daniel P. Bezerra
Acute myelogenous leukaemia (AML) originates and is maintained by leukaemic stem cells (LSCs) that are inherently resistant to antiproliferative therapies, indicating that a critical strategy for overcoming chemoresistance in AML therapy is to eradicate LSCs. In this work, we investigated the anti‐AML activity of bortezomib (BTZ), emphasizing its anti‐LSC potential, using KG‐1a cells, an AML cell line
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Non‐apoptotic regulated cell death mediates reprogramming of the tumour immune microenvironment by macrophages J. Cell. Mol. Med. (IF 5.3) Pub Date : 2024-04-23 Chengpeng Sun, Jianhao Zhan, Yao Li, Chulin Zhou, Shuo Huang, Xingen Zhu, Kai Huang
Tumour immune microenvironment (TIME) plays an indispensable role in tumour progression, and tumour‐associated macrophages (TAMs) are the most abundant immune cells in TIME. Non‐apoptotic regulated cell death (RCD) can avoid the influence of tumour apoptosis resistance on anti‐tumour immune response. Specifically, autophagy, ferroptosis, pyroptosis and necroptosis mediate the crosstalk between TAMs
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Dihydroartemisinin induces ferroptosis of hepatocellular carcinoma via inhibiting ATF4‐xCT pathway J. Cell. Mol. Med. (IF 5.3) Pub Date : 2024-04-23 Jie Ji, Ziqi Cheng, Jie Zhang, Jianye Wu, Xuanfu Xu, Chuanyong Guo, Jiao Feng
Management of hepatocellular carcinoma (HCC) remains challenging due to population growth, frequent recurrence and drug resistance. Targeting of genes involved with the ferroptosis is a promising alternative treatment strategy for HCC. The present study aimed to investigate the effect of dihydroartemisinin (DHA) against HCC and explore the underlying mechanisms. The effects of DHA on induction of ferroptosis
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An integrated analysis of the anticarcinogenic role of forkhead box protein 1 in oesophageal squamous cell carcinoma J. Cell. Mol. Med. (IF 5.3) Pub Date : 2024-04-23 Guanzhi Ye, Gaojian Pan, Xiaolei Zhu, Ning Li, Hongming Liu, Guojun Geng, Jie Jiang
Forkhead box protein 1 (FOXP1) serves as a tumour promoter or suppressor depending on different cancers, but its effect in oesophageal squamous cell carcinoma has not been fully elucidated. This study investigated the role of FOXP1 in oesophageal squamous cell carcinoma through bioinformatics analysis and experimental verification. We determined through public databases that FOXP1 expresses low in
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Proteomic studies in VWA1‐related neuromyopathy allowed new pathophysiological insights and the definition of blood biomarkers J. Cell. Mol. Med. (IF 5.3) Pub Date : 2024-04-23 Mohammed Athamneh, Nassam Daya, Andreas Hentschel, Andrea Gangfuss, Tobias Ruck, Adela Della Marina, Ulrike Schara‐Schmidt, Albert Sickmann, Anne‐Katrin Güttsches, Marcus Deschauer, Corinna Preusse, Matthias Vorgerd, Andreas Roos
Bi‐allelic variants in VWA1, encoding Von Willebrand Factor A domain containing 1 protein localized to the extracellular matrix (ECM), were linked to a neuromuscular disorder with manifestation in child‐ or adulthood. Clinical findings indicate a neuromyopathy presenting with muscle weakness. Given that pathophysiological processes are still incompletely understood, and biomarkers are still missing
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Identification of PPAR‐related differentially expressed genes liver hepatocellular carcinoma and construction of a prognostic model based on data analysis and molecular docking J. Cell. Mol. Med. (IF 5.3) Pub Date : 2024-04-23 Yumeng Wang, Shuqiang Li, Zihang Liu, Xuanzheng Li, Yifan Yu, Hao Liu
Liver hepatocellular carcinoma (LIHC) is a significant global health issue with limited treatment options. In this study, single‐cell RNA sequencing (scRNA‐seq) data were used to explore the molecular mechanisms of LIHC development and identify potential targets for therapy. The expression of peroxisome proliferator‐activated receptors (PPAR)‐related genes was analysed in LIHC samples, and primary
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MELK aggravates lung adenocarcinoma by regulating EZH2 ubiquitination and H3K27me3 histone methylation of LATS2 J. Cell. Mol. Med. (IF 5.3) Pub Date : 2024-04-23 Hui Yu, Xianrong Xu, Lirong Zhu, Shengjie Chen, Jincheng He
We tried to elucidate the possible roles of maternal embryonic leucine pull chain kinase (MELK) in lung adenocarcinoma (LUAD) growth and metastasis. Differentially expressed genes in LUAD samples were analysed by the GEPIA database. Clinical tissue samples and cells were collected for MELK, EZH2 and LATS2 expression determination. Co‐IP assay was used to verify the interaction between EZH2 and MELK;
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Macrophage‐derived extracellular vesicles alter cardiac recovery and metabolism in a rat heart model of donation after circulatory death J. Cell. Mol. Med. (IF 5.3) Pub Date : 2024-04-23 Selianne Graf, Vanessa Biemmi, Maria Arnold, Adrian Segiser, Anja Müller, Natalia Méndez‐Carmona, Manuel Egle, Matthias Siepe, Lucio Barile, Sarah Longnus
Conditions to which the cardiac graft is exposed during transplantation with donation after circulatory death (DCD) can trigger the recruitment of macrophages that are either unpolarized (M0) or pro‐inflammatory (M1) as well as the release of extracellular vesicles (EV). We aimed to characterize the effects of M0 and M1 macrophage‐derived EV administration on post‐ischaemic functional recovery and
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Development of m6A/m5C/m1A regulated lncRNA signature for prognostic prediction, personalized immune intervention and drug selection in LUAD J. Cell. Mol. Med. (IF 5.3) Pub Date : 2024-04-22 Chao Ma, Zhuoyu Gu, Yang Yang
Research indicates that there are links between m6A, m5C and m1A modifications and the development of different types of tumours. However, it is not yet clear if these modifications are involved in the prognosis of LUAD. The TCGA‐LUAD dataset was used as for signature training, while the validation cohort was created by amalgamating publicly accessible GEO datasets including GSE29013, GSE30219, GSE31210
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From phenotype to mechanism: Prenatal spectrum of NKAP mutation‐related disorder and its pathogenesis inducing congenital heart disease J. Cell. Mol. Med. (IF 5.3) Pub Date : 2024-04-22 Xiayuan Xu, Chengcheng Gao, Fenglei Ye, Aohui Peng, Jianbo Xu, Keqin Jin, Jun Zhang, Yun Ye, Yanfen Yang, Xuan Zhang, Shuangshuang Shen, Fan Jin
NKAP mutations are associated with Hackmann‐Di Donato‐type X‐linked syndromic intellectual developmental disorder (MRXSHD, MIM: #301039). Here, we elucidate the potential prenatal manifestation of NKAP mutation‐associated disorder for the first time, alongside revealing the relationship between NKAP mutations and congenital heart defect (CHD) in the Chinese population. An NKAP mutation (NM_024528.4:
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Single‐cell analysis revealed a potential role of T‐cell exhaustion in colorectal cancer with liver metastasis J. Cell. Mol. Med. (IF 5.3) Pub Date : 2024-04-22 Tianlong Ling, Cheng Zhang, Ye Liu, Chunhui Jiang, Lei Gu
Liver metastasis (LM) is an important factor leading to colorectal cancer (CRC) mortality. However, the effect of T‐cell exhaustion on LM in CRC is unclear. Single‐cell sequencing data derived from the Gene Expression Omnibus database. Data were normalized using the Seurat package and subsequently clustered and annotated into different cell clusters. The differentiation trajectories of epithelial cells
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A robust computational quest: Discovering potential hits to improve the treatment of pyrazinamide‐resistant Mycobacterium tuberculosis J. Cell. Mol. Med. (IF 5.3) Pub Date : 2024-04-18 Muhammad Shahab, Gabriel Christian de Farias Morais, Shopnil Akash, Umberto Laino Fulco, Jonas Ivan Nobre Oliveira, Guojun Zheng, Shahina Akter
The rise of pyrazinamide (PZA)‐resistant strains of Mycobacterium tuberculosis (MTB) poses a major challenge to conventional tuberculosis (TB) treatments. PZA, a cornerstone of TB therapy, must be activated by the mycobacterial enzyme pyrazinamidase (PZase) to convert its active form, pyrazinoic acid, which targets the ribosomal protein S1. Resistance, often associated with mutations in the RpsA protein
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Impacts of pro‐inflammatory cytokines variant on cardiometabolic profile and premature coronary artery disease: A systematic review and meta‐analysis J. Cell. Mol. Med. (IF 5.3) Pub Date : 2024-04-18 Yang Liu, Yuan Chen, Yi Lin, Baozhu Wei, Zhi Luo
Interleukin‐6 (IL‐6), a pivotal pro‐inflammatory cytokine, is closely linked to vascular wall thickening and atherosclerotic lesion. Since serum IL‐6 levels are largely determined by the genetic variant in IL‐6, this study was conducted to investigate whether the IL‐6 variant impacts cardiometabolic profile and the risk of premature coronary artery disease (PCAD). PubMed, Cochrane Library, Central
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Integrated analyses for identification of a three‐gene signature associated with Chaihu Shugan San formula for hepatocellular carcinoma treatment J. Cell. Mol. Med. (IF 5.3) Pub Date : 2024-04-13 Jia‐heng Xing, Ru‐xue Tan, Fei‐er Huang, Nan Tian
Chaihu Shugan San (CSS) is a well‐known traditional herbal formula that has the potential to ameliorate hepatocellular carcinoma (HCC); however, its mechanism of action remains unknown. Here, we identified the key targets of CSS against HCC and developed a prognostic model to predict the survival of patients with HCC. The effect of CSS plus sorafenib on HCC cell proliferation was evaluated using the
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The role of autophagy in odontogenesis, dental implant surgery, periapical and periodontal diseases J. Cell. Mol. Med. (IF 5.3) Pub Date : 2024-04-13 Sevinç İnan, Emre Barış
Autophagy is a cellular process that is evolutionarily conserved, involving the sequestration of damaged organelles and proteins into autophagic vesicles, which subsequently fuse with lysosomes for degradation. Autophagy controls the development of many diseases by influencing apoptosis, inflammation, the immune response and different cellular processes. Autophagy plays a significant role in the aetiology
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The Hippo signalling pathway and its impact on eye diseases J. Cell. Mol. Med. (IF 5.3) Pub Date : 2024-04-13 Yuxiang Du
The Hippo signalling pathway, an evolutionarily conserved kinase cascade, has been shown to be crucial for cell fate determination, homeostasis and tissue regeneration. Recent experimental and clinical studies have demonstrated that the Hippo signalling pathway is involved in the pathophysiology of ocular diseases. This article provides the first systematic review of studies on the regulatory and functional
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Deferoxamine topical cream superior to patch in rescuing radiation‐induced fibrosis of unwounded and wounded skin J. Cell. Mol. Med. (IF 5.3) Pub Date : 2024-04-13 Charlotte E. Berry, Darren B. Abbas, Michelle Griffin, Hendrik Lintel, Jason Guo, Lionel Kameni, Andrew A. Churukian, Alexander Z. Fazilat, Kellen Chen, Geoffrey C. Gurtner, Michael T. Longaker, Arash Momeni, Derrick C. Wan
Topical patch delivery of deferoxamine (DFO) has been studied as a treatment for this fibrotic transformation in irradiated tissue. Efficacy of a novel cream formulation of DFO was studied as a RIF therapeutic in unwounded and excisionally wounded irradiated skin. C57BL/6J mice underwent 30 Gy of radiation to the dorsum followed by 4 weeks of recovery. In a first experiment, mice were separated into
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The plasma miRNome and venous thromboembolism in high‐grade glioma: miRNA Sequencing of a nested case–control cohort J. Cell. Mol. Med. (IF 5.3) Pub Date : 2024-04-13 Friedrich Erhart, Georg Widhalm, Barbara Kiesel, Matthias Hackl, Andreas Diendorfer, Matthias Preusser, Karl Rössler, Johannes Thaler, Ingrid Pabinger, Cihan Ay, Julia Riedl
Patients with high‐grade gliomas are at high risk of venous thromboembolism (VTE). MicroRNAs (miRNAs) are small non‐coding RNAs with multiple roles in tumour biology, haemostasis and platelet function. Their association with VTE risk in high‐grade glioma has not been comprehensively mapped so far. We thus conducted a nested case–control study within 152 patients with WHO grade IV glioma that had been
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A 78‐year‐old woman with diffuse white matter infiltration and predominant involvement of bilateral temporo‐parieto‐occipital regions J. Cell. Mol. Med. (IF 5.3) Pub Date : 2024-04-13 Charlotte Paoli, Anne Mc Leer, Julien Boyer, Lydiane Mondot, Bérengère Dadone‐Montaudié, Catherine Godfraind, Fanny Burel‐Vandenbos
Diffuse paediatric‐type high‐grade glioma, H3‐wildtype and IDH‐wildtype (H3/IDH‐wt‐pHGG) is a newly defined entity amongst brain tumours, primarily reported in children. It is a rare, ill‐defined type of tumour and the only method to diagnose it is DNA methylation profiling. The case we report here carries new knowledge about this tumour which may, in fact, occur in elderly patients, be devoid of evocative
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Pathway‐based stratification of gliomas uncovers four subtypes with different TME characteristics and prognosis J. Cell. Mol. Med. (IF 5.3) Pub Date : 2024-04-13 Ruoyu Huang, Bo Han, Ying Zhang, Jingchen Yang, Kuanyu Wang, Xing Liu, Zhiliang Wang
Increasing evidences have found that the interactions between hypoxia, immune response and metabolism status in tumour microenvironment (TME) have clinical importance of predicting clinical outcomes and therapeutic efficacy. This study aimed to develop a reliable molecular stratification based on these key components of TME. The TCGA data set (training cohort) and two independent cohorts from CGGA
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Integrated analysis highlights the significance role of ITGAL in lung adenocarcinoma J. Cell. Mol. Med. (IF 5.3) Pub Date : 2024-04-13 Zengtuan Xiao, Zhe Nian, Mengzhe Zhang, Zuo Liu, Zhe Liu, Zhenfa Zhang
Integrin alpha L (ITGAL), a member of the integrin family, is associated with carcinogenesis and immune regulation. However, the biological functions of ITGAL in lung adenocarcinoma (LUAD) remain poorly understood. In this study, we utilized the TCGA dataset to analyse ITGAL mRNA expression in LUAD and examined its correlation with clinical prognosis. Three‐dimensional (3D) Matrigel culture, 5‐bromodeoxyuridine
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Pyrroloquinoline quinone ameliorates PM2.5‐induced pulmonary fibrosis through targeting epithelial–mesenchymal transition J. Cell. Mol. Med. (IF 5.3) Pub Date : 2024-04-13 Chia‐Chia Chao, Sheng‐Yen Hsiao, Wan‐Chen Kao, Pei‐Chen Chiou, Chieh‐Chen Huang, Mei‐Ting Wang, Po‐Chun Chen
Pulmonary fibrosis is a lung disorder affecting the lungs that involves the overexpressed extracellular matrix, scarring and stiffening of tissue. The repair of lung tissue after injury relies heavily on Type II alveolar epithelial cells (AEII), and repeated damage to these cells is a crucial factor in the development of pulmonary fibrosis. Studies have demonstrated that chronic exposure to PM2.5,
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Effect of Curcuma longa extract on reproduction function in mice and testosterone production in Leydig cells J. Cell. Mol. Med. (IF 5.3) Pub Date : 2024-04-13 Yisheng Zhang, Liu Yang, Shan Xue, Yichang Zhang, Zihan Li, Min Zhang, Guoyin Kai, Juan Li
Curcuma longa, best known for its culinary application as the main constituent of curry powder, has shown potential impact on the reproductive system. This study aimed to investigate the efficacy of Curcuma longa extract (CLE) on Kidney‐Yang deficiency mice induced by hydrocortisone and the possible roles in testosterone secretion in Leydig cells. We evaluated male sexual behaviour, reproductive organ
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Identification and characterization of novel genetic variants in the first Chinese family of mucopolysaccharidosis IIIC (Sanfilippo C syndrome) J. Cell. Mol. Med. (IF 5.3) Pub Date : 2024-04-13 Hongjun Zhao, Lijing Wang, Mengfei Zhang, Huakun Wang, Sizhe Zhang, Junjiao Wu, Yu Tang
Mucopolysaccharidosis type IIIC (MPS IIIC) is one of inherited lysosomal storage disorders, caused by deficiencies in lysosomal hydrolases degrading acidic mucopolysaccharides. The gene responsible for MPS IIIC is HGSNAT, which encodes an enzyme that catalyses the acetylation of the terminal glucosamine residues of heparan sulfate. So far, few studies have focused on the genetic landscape of MPS IIIC
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Comprehensive analysis of the interaction of antigen presentation during anti‐tumour immunity and establishment of AIDPS systems in ovarian cancer J. Cell. Mol. Med. (IF 5.3) Pub Date : 2024-04-13 Wenhuizi Sun, Ping Xu, Kefei Gao, Wenqin Lian, Xiang Sun
There are hundreds of prognostic models for ovarian cancer. These genes are based on different gene classes, and there are many ways to construct the models. Therefore, this paper aims to build the most stable prognostic evaluation system known to date through 101 machine learning strategies. We combined 101 algorithm combinations with 10 machine learning algorithms to create antigen presentation‐associated
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YAP/TAZ‐TEAD signalling axis: A new therapeutic target in malignant pleural mesothelioma J. Cell. Mol. Med. (IF 5.3) Pub Date : 2024-04-12 Kostas A. Papavassiliou, Amalia A. Sofianidi, Athanasios G. Papavassiliou
The Hippo signalling pathway, a highly conserved signalling cassette, regulates organ size by controlling cell growth, apoptosis and stem cell self‐renewal. The tumourigenic potential of this pathway is largely attributed to the activity of YAP/TAZ, which activate the TEAD1‐4 transcription factors, leading to the expression of genes involved in cell proliferation and suppression of cell death. Aberrant
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Engeletin alleviates depressive‐like behaviours by modulating microglial polarization via the LCN2/CXCL10 signalling pathway J. Cell. Mol. Med. (IF 5.3) Pub Date : 2024-04-10 Jie Zhang, Zheng Song, Yanchao Huo, Guangqiang Li, Liming Lu, Chuanmei Wei, Shuping Zhang, Xinfu Gao, Xingyue Jiang, Yangyang Xu
Microglial polarization and associated inflammatory activity are the key mediators of depression pathogenesis. The natural Smilax glabra rhizomilax derivative engeletin has been reported to exhibit robust anti‐inflammatory activity, but no studies to date have examined the mechanisms through which it can treat depressive symptoms. We showed that treatment for 21 days with engeletin significantly alleviated
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Purine metabolism in lung adenocarcinoma: A single‐cell analysis revealing prognostic and immunotherapeutic insights J. Cell. Mol. Med. (IF 5.3) Pub Date : 2024-04-10 Pengpeng Zhang, Shengbin Pei, Guangyao Zhou, Mengzhe Zhang, Lianmin Zhang, Zhenfa Zhang
Lung adenocarcinoma (LUAD) is a prevalent subtype of lung cancer, yet the contribution of purine metabolism (PM) to its pathogenesis remains poorly elucidated. PM, a critical component of intracellular nucleotide synthesis and energy metabolism, is hypothesized to exert a significant influence on LUAD development. Herein, we employed single‐cell analysis to investigate the role of PM within the tumour
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Irradiated riboflavin over nonradiated one: Potent antimigratory, antiproliferative and cytotoxic effects on glioblastoma cells J. Cell. Mol. Med. (IF 5.3) Pub Date : 2024-04-10 Sedat Kacar, Ceyhan Hacioglu, Fatih Kar
Riboflavin is a water‐soluble yellowish vitamin and is controversial regarding its effect on tumour cells. Riboflavin is a powerful photosensitizer that upon exposure to radiation, undergoes an intersystem conversion with molecular oxygen, leading to the production of ROS. In the current study, we sought to ascertain the impact of irradiated riboflavin on C6 glioblastoma cells regarding proliferation
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A single‐chain antibody construct with specificity of a natural IgM antibody reduces hepatic ischemia reperfusion injury in mice J. Cell. Mol. Med. (IF 5.3) Pub Date : 2024-04-10 Zhi Yang, Chunmei Li, Yongqin Wang, Wei Dong, Moujie Yang, Junfei Jin
Natural immunoglobulin M (IgM) antibodies have been shown to recognize post‐ischemic neoepitopes following reperfusion of tissues and to activate complement. Specifically, IgM antibodies and complement have been shown to drive hepatic ischemia reperfusion injury (IRI). Herein, we investigate the therapeutic effect of C2 scFv (single‐chain antibody construct with specificity of a natural IgM antibody)
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Capsiate ameliorates secondary hyperparathyroidism by improving insulin sensitivity and inhibiting angiogenesis J. Cell. Mol. Med. (IF 5.3) Pub Date : 2024-04-09 Peiting Li, Jianda Zhou, Tianyin Wang, Jun Li, Wei Wu
Secondary hyperparathyroidism has a significant impact on the overall well‐being of the body. Capsiates, known for their antioxidant and metabolic properties, have emerged as a promising alternative treatment for secondary hyperparathyroidism. This study aims to evaluate the effects and mechanisms of capsiates in the treatment of secondary hyperparathyroidism. To achieve our research objectives, we
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GHITM regulates malignant phenotype and sensitivity to PD‐1 blockade of renal cancer cells via Notch signalling J. Cell. Mol. Med. (IF 5.3) Pub Date : 2024-04-08 Shiyu Huang, Jiachen Liu, Juncheng Hu, Yanguang Hou, Min Hu, Banghua Zhang, Hongbo Luo, Shujie Fu, Yujie Chen, Xiuheng Liu, Zhiyuan Chen, Lei Wang
Growth hormone inducible transmembrane protein (GHITM), one member of Bax inhibitory protein‐like family, has been rarely studied, and the clinical importance and biological functions of GHITM in kidney renal clear cell carcinoma (KIRC) still remain unknown. In the present study, we found that GHITM was downregulated in KIRC. Aberrant GHITM downregulation related to clinicopathological feature and
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PGC‐1α regulates the interplay between oxidative stress, senescence and autophagy in the ageing retina important in age‐related macular degeneration J. Cell. Mol. Med. (IF 5.3) Pub Date : 2024-04-04 Iswariyaraja Sridevi Gurubaran, Cezary Watala, Joanna Kostanek, Joanna Szczepanska, Elzbieta Pawlowska, Kai Kaarniranta, Janusz Blasiak
We previously showed that mice with knockout in the peroxisome proliferator‐activated receptor gamma coactivator 1‐alpha (PPARGC1A) gene encoding the PGC‐1α protein, and nuclear factor erythroid 2 like 2 (NFE2L2) gene, exhibited some features of the age‐related macular degeneration (AMD) phenotype. To further explore the mechanism behind the involvement of PGC‐1α in AMD pathogenesis we used young (3‐month)
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A novel long non‐coding RNALINC00524 facilitates invasion and metastasis through interaction with TDP43 in breast cancer J. Cell. Mol. Med. (IF 5.3) Pub Date : 2024-04-03 Xianglin Sun, Wenfeng Li, Gang Li, Huan Yang, Zhenglin Jiang, Lihua Shen, Yuexiang Shen, Yifei Liu, Guohua Wang
Breast cancer (BC) remains a significant health concern worldwide, with metastasis being a primary contributor to patient mortality. While advances in understanding the disease's progression continue, the underlying mechanisms, particularly the roles of long non‐coding RNAs (lncRNAs), are not fully deciphered. In this study, we examined the influence of the lncRNA LINC00524 on BC invasion and metastasis
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Integrative analysis unveils ECM signatures and pathways driving hepatocellular carcinoma progression: A multi‐omics approach and prognostic model development J. Cell. Mol. Med. (IF 5.3) Pub Date : 2024-04-03 Zhen Liu, Pengfei Zhao
Liver hepatocellular carcinoma (LIHC) is a highly lethal form of cancer that is among the deadliest cancer types globally. In terms of cancer‐related mortality rates, liver cancer ranks among the top three, underscoring the severity of this disease. Insufficient analysis has been conducted to fully understand the potential value of the extracellular matrix (ECM) in immune infiltration and the prognostic
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CircPVT1 promotes migration and invasion by regulating miR‐490‐5p/HAVCR2 axis in osteosarcoma cells J. Cell. Mol. Med. (IF 5.3) Pub Date : 2024-04-03 Chunbin Zhou, Lois Balmer, Manshu Song, Kezhou Wu, Wei Wang, Hu Wang
Circular RNAs (circRNAs) play an important role in the progression of osteosarcoma. However, the precise function of circPVT1 in osteosarcoma remains elusive. This study aims to explore the molecular mechanism underlying the involvement of circPVT1 in osteosarcoma cells. We quantified circPVT1 expression using qRT‐PCR in both control and osteosarcoma cell lines. To investigate the roles of circPVT1
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Peripheral nerve‐derived Sema3A promotes osteogenic differentiation of mesenchymal stem cells through the Wnt/β‐catenin/Nrp1 positive feedback loop J. Cell. Mol. Med. (IF 5.3) Pub Date : 2024-04-03 Jingcun Shi, Bingqing Zhang, Ziqian Wu, Yuhan Zhang, Anand Gupta, Xudong Wang, Jieyu Wang, Lisha Pan, Meng Xiao, Shijian Zhang, Lei Wang
Sensory nerves play a crucial role in maintaining bone homeostasis by releasing Semaphorin 3A (Sema3A). However, the specific mechanism of Sema3A in regulation of bone marrow mesenchymal stem cells (BMMSCs) during bone remodelling remains unclear. The tibial denervation model was used and the denervated tibia exhibited significantly lower mass as compared to sham operated bones. In vitro, BMMSCs cocultured
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RhoA/rho kinase pathway activation in age‐associated endothelial cell dysfunction and thrombosis J. Cell. Mol. Med. (IF 5.3) Pub Date : 2024-04-03 Iván Palomo, Sergio Wehinger, Vicente Andrés, Francisco J. García‐García, Eduardo Fuentes
The small GTPase RhoA and the downstream Rho kinase (ROCK) regulate several cell functions and pathological processes in the vascular system that contribute to the age‐dependent risk of cardiovascular disease, including endothelial dysfunction, excessive permeability, inflammation, impaired angiogenesis, abnormal vasoconstriction, decreased nitric oxide production and apoptosis. Frailty is a loss of
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The association between serum copper concentration and prevalence of diabetes among US adults with hypertension (NHANES 2011–2016) J. Cell. Mol. Med. (IF 5.3) Pub Date : 2024-04-03 Kaiming Wu, Lixia Chen, Yanyan Kong, Jian‐Feng Zhuo, Qiu Sun, Jianfei Chang
The objective of this study was to examine the association between the serum copper concentration and the prevalence of diabetes among US adults with hypertension using the data from the National Health and Nutrition Examination Survey (NHANES). The study population was selected from adults aged over 20 years old in the three survey cycles of NHANES from 2011 to 2016. Logistic regression model analyses
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Development, synthesis and validation of improved c‐Myc/Max inhibitors J. Cell. Mol. Med. (IF 5.3) Pub Date : 2024-04-03 Sümbül Yıldırım, Fatih Kocabaş, Arif Mermer
The pathophysiological foundations of various diseases are often subject to alteration through the utilization of small compounds, rendering them invaluable tools for the exploration and advancement of novel therapeutic strategies. Within the scope of this study, we meticulously curated a diverse library of novel small compounds meticulously designed to specifically target the c‐Myc/Max complex. We
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Bergamot essential oil improves CUMS‐induced depression‐like behaviour in rats by protecting the plasticity of hippocampal neurons J. Cell. Mol. Med. (IF 5.3) Pub Date : 2024-03-30 Jun Chang, Huimin Yang, Xiaoqian Shan, Lan Zhao, Yujiao Li, Zhao Zhang, Joseph Kofi Abankwah, Mingxing Zhang, Yuhong Bian, Yi Guo
Bergamot essential oil (BEO) is an extract of the bergamot fruit with significant neuroprotective effect. This study was to investigate the effects and the underlying mechanism of BEO in mitigating depression. GC–MS were used to identify its constituents. Antidepressive properties of BEO were evaluated by sucrose preference test (SPT), force swimming test (FST) and open field test (OFT). Nissl staining
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HINT2 protects against pressure overload‐induced cardiac remodelling through mitochondrial pathways J. Cell. Mol. Med. (IF 5.3) Pub Date : 2024-03-28 Nan Zhang, Zi‐Ying Zhou, Yan‐Yan Meng, Hai‐Han Liao, Shan‐Qi Mou, Zheng Lin, Han Yan, Si Chen, Qi‐Zhu Tang
Histidine triad nucleotide‐binding protein 2 (HINT2) is an enzyme found in mitochondria that functions as a nucleotide hydrolase and transferase. Prior studies have demonstrated that HINT2 plays a crucial role in ischemic heart disease, but its importance in cardiac remodelling remains unknown. Therefore, the current study intends to determine the role of HINT2 in cardiac remodelling. HINT2 expression
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KLF transcription factors in bone diseases J. Cell. Mol. Med. (IF 5.3) Pub Date : 2024-03-28 Haixia Wang, Juanjuan Han, Gorbachev Dmitrii, Ke Ning, Xin‐an Zhang
Krüppel‐like factors (KLFs) are crucial in the development of bone disease. They are a family of zinc finger transcription factors that are unusual in containing three highly conserved zinc finger structural domains interacting with DNA. It has been discovered that it engages in various cell functions, including proliferation, apoptosis, autophagy, stemness, invasion and migration, and is crucial for
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Role of the gut microbiota and innate immunity in polycystic ovary syndrome: Current updates and future prospects J. Cell. Mol. Med. (IF 5.3) Pub Date : 2024-03-28 Min Zhou, Jing Yu, Xuewei Li, Zheng Ruan, Shaohui Yu
Polycystic ovary syndrome (PCOS) is one of the modern intractable reproductive diseases. The female irregular menstruation, infertility, obesity, and so forth caused by PCOS have become a hot issue affecting family harmony and social development. The aetiology of PCOS is complex. In recent years, many scholars have found that its pathogenesis was related to the imbalance of gut microbiota. Gut microbiota
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Research progress of the netrins and their receptors in cancer J. Cell. Mol. Med. (IF 5.3) Pub Date : 2024-03-28 Xing Gao, Jiazhou Ye, Xi Huang, Shilin Huang, Wenfeng Luo, Dandan Zeng, Shizhou Li, Minchao Tang, Rongyun Mai, Yongqiang Li, Yan Lin, Rong Liang
Netrins, a family of secreted and membrane‐associated proteins, can regulate axonal guidance, morphogenesis, angiogenesis, cell migration, cell survival, and tumorigenesis. Four secreted netrins (netrin 1, 3, 4 and 5) and two glycosylphosphatidylinositols‐anchored membrane proteins, netrin‐G1 and G2, have been identified in mammals. Netrins and their receptors can serve as a biomarker and molecular
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Autosomal recessive non‐syndromic hearing loss genes in Pakistan during the previous three decades J. Cell. Mol. Med. (IF 5.3) Pub Date : 2024-03-27 Madiha Shadab, Ansar Ahmed Abbasi, Ahsan Ejaz, Afif Ben‐Mahmoud, Vijay Gupta, Hyung‐Goo Kim, Barbara Vona
Hearing loss is a clinically and genetically heterogeneous disorder, with over 148 genes and 170 loci associated with its pathogenesis. The spectrum and frequency of causal variants vary across different genetic ancestries and are more prevalent in populations that practice consanguineous marriages. Pakistan has a rich history of autosomal recessive gene discovery related to non‐syndromic hearing loss
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Mitochondrial respiration in peripheral arterial disease depends on stage severity J. Cell. Mol. Med. (IF 5.3) Pub Date : 2024-03-27 Fiona Speichinger, Alexandra Gratl, Ben Raude, Larissa Schawe, Jan Carstens, Nina A. Hering, Andreas Greiner, Dominik Pesta, Jan Paul Frese
Peripheral arterial disease (PAD) is an increasing cause of morbidity and its severity is graded based on clinical manifestation. To investigate the influence of the different stages on myopathy of ischemic muscle we analysed severity‐dependent effects of mitochondrial respiration in PAD. Eighteen patients with severe PAD, defined as chronic limb‐threatening ischemia, 47 patients with intermittent
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Hepatoprotective activity of Lactéol® forte and quercetin dihydrate against thioacetamide‐induced hepatic cirrhosis in male albino rats J. Cell. Mol. Med. (IF 5.3) Pub Date : 2024-03-27 Hebatallah M. Saad, Samah S. Oda, Athanasios Alexiou, Marios Papadakis, Mohamed H. Mahmoud, Gaber El‐Saber Batiha, Eman Khalifa
Liver cirrhosis is a silent disease in humans and is experimentally induced by many drugs and toxins as thioacetamide (TAA) in particular, which is the typical model for experimental induction of hepatic fibrosis. Thus, the objective of the present study was to elucidate the possible protective effects of lactéol® forte (LF) and quercetin dihydrate (QD) against TAA‐induced hepatic damage in male albino
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A novel mitochondria‐related core gene signature to predict the prognosis and evaluate tumour microenvironment in CESC single‐cell validation J. Cell. Mol. Med. (IF 5.3) Pub Date : 2024-03-27 Lingxiao Ying, Lin Kong, Xiaoxiao Qiu, Aihua Cheng, Qijun Wang, Limeng Xiu, Jinmei Shi, Yanfei Tao, Zhihong Chai
Mitochondria and their related genes (MTRGs) are pivotal in the tumour microenvironment (TME) of cervical cancer, influencing prognosis and treatment response. This study developed a prognostic model using MTRGs to predict overall survival (OS) in cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), aiming for personalized therapy. Analysing 14 MTRGs like ISCU and NDUFA11 through
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Integration of single‐cell and RNA‐seq data to explore the role of focal adhesion‐related genes in osteoporosis J. Cell. Mol. Med. (IF 5.3) Pub Date : 2024-03-27 Xiaojian Shi, Qiang Fu, Jianyu Mao, Jiajie Yang, Ye Chen, Jiajia Lu, Aimin Chen, Nan Lu
Integrin‐based focal adhesion is one of the major mechanosensory in osteocytes. The aim of this study was to mine the hub genes associated with focal adhesion and investigate their roles in osteoporosis based on the data of single‐cell RNA sequencing and RNA‐sequencing. Two hub genes (FAM129A and RNF24) with the same expression trend and AUC values greater than 0.7 in both GSE56815 and GSE56116 cohorts
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Depletion of CPNE7 sensitizes colorectal cancer to 5‐fluorouracil by downregulating ATG9B expression J. Cell. Mol. Med. (IF 5.3) Pub Date : 2024-03-25 Weile Xu, Yujie Tang, Yang Yang, Changjing Wang, Chen Liu, Jianqing Zhang, Lianmei Zhao, Guiying Wang
We aimed to explore the biological function of CPNE7 and determine the impact of CPNE7 on chemotherapy resistance in colorectal cancer (CRC) patients. According to the Gene Expression Profiling Interactive Analysis database and previously published data, CPNE7 was identified as a potential oncogene in CRC. RT‐qPCR and Western blotting were performed to verify the expression of CPNE7. Chi‐square test
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The KIR2DL family serves as prognostic biomarkers and correlates with immune infiltrates in acute myeloid leukaemia J. Cell. Mol. Med. (IF 5.3) Pub Date : 2024-03-25 Wenling Liu, Mingming Zhu, Ganggang Li, Yaming Xi
Acute myeloid leukaemia (AML) is a prevalent haematological malignancy in which various immune and stromal cells in the bone marrow microenvironment have instrumental roles and substantially influence its progression. KIR2DL is a member of the immunoglobulin‐like receptor family and a natural killer (NK) cell surface‐specific receptor. However, its impact on immune infiltration regarding AML has not
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Causal effect of gut microbiota on pancreatic cancer: A Mendelian randomization and colocalization study J. Cell. Mol. Med. (IF 5.3) Pub Date : 2024-03-25 Xin Li, Zhihai Liang
The causal relationship between gut microbiota (GM) and pancreatic cancer (PC) remains unclear. This study aimed to investigate the potential genes underlying this mechanism. GM Genome‐wide association study (GWAS) summary data were from the MiBioGen consortium. PC GWAS data were from the National Human Genome Research Institute‐European Bioinformatics Institute (NHGRI‐EBI) GWAS Catalogue. To detect
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Huayu Qutan Recipe promotes lipophagy and cholesterol efflux through the mTORC1/TFEB/ABCA1‐SCARB1 signal axis J. Cell. Mol. Med. (IF 5.3) Pub Date : 2024-03-25 Yue Li, Jiaxiang Pan, J. J. Jiajia Yu, Xize Wu, Guanlin Yang, Xue Pan, Guoyuan Sui, Mingyang Wang, Meijia Cheng, Shu Zhu, He Tai, Honghe Xiao, Lili Xu, Jin Wu, Yongju Yang, Jing Tang, Lihong Gong, Lianqun Jia, Dongyu Min
This study aims to investigate the mechanism of the anti‐atherosclerosis effect of Huayu Qutan Recipe (HYQT) on the inhibition of foam cell formation. In vivo, the mice were randomly divided into three groups: CTRL group, MOD group and HYQT group. The HYQT group received HYQT oral administration twice a day (20.54 g/kg/d), and the plaque formation in ApoE−/− mice was observed using haematoxylin–eosin