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Computational and experimental strategies for combating MBL P. aeruginosa (MBLPA) biofilms using phytochemicals: Targeting the quorum sensing network Saudi J. Biol. Sci. (IF 4.4) Pub Date : 2024-04-16 Maryum Fakhar, Mehboob Ahmed, Anjum Nasim Sabri
is a Gram-negative opportunistic bacterium, ubiquitously found in nature and causative agent in many infections. Due to increased antibiotic resistance, there is a need to develop more robust antibacterial agents from natural sources. In this study, we worked on two metallo-β-lactamase (MBL) producing strains and targeted the Quorum Sensing mechanism (QS) of these bacteria to combat antibiotic resistance
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Growth enhancement and changes in bacterial microbiome of cucumber plants exhibited by biopriming with some native bacteria Saudi J. Biol. Sci. (IF 4.4) Pub Date : 2024-04-16 Navya Botlagunta, Subramanian Babu
This study investigated the impact of a mixture of six endophytic bacterial strains isolated from cucumber plants on the growth and microbiome diversity of six cucumber traditionalvarieties and hybrids.Six bacterial species were isolated and identified by 16 s rRNA sequencing. All the bacteria showed plant growth promoting traits.showed 80 % inhibition of the mycelia growth of f.sp.(Foc). Mixed culture
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Combined effect of brazilin-rich extract and lawsone methyl ether against infection-causing bacteria Saudi J. Biol. Sci. (IF 4.4) Pub Date : 2024-04-15 Nilesh Nirmal, Pankaj Koirala, Anandu Chandra Khanashyam, Pharkphoom Panichayupakaranant, Abdi Wira Septama
Bacterial contamination and infection widely affect the food, pharmaceutical and biomedical industries. Additionally, these bacteria developed resistance to synthetic antibiotics causing public health danger, globally. Natural plant extracts (NPE) are suitable alternatives to synthetic antibiotics to tackle antimicrobial resistance problems. Furthermore, a blend or combination of different NPEs exerts
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Unraveling potential neuroprotective mechanisms of herbal medicine for Alzheimer’s diseases through comprehensive molecular docking analyses Saudi J. Biol. Sci. (IF 4.4) Pub Date : 2024-04-15 Faisal Alsenani
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Authentication of important medicinal herbal species through DNA-based molecular characterization Saudi J. Biol. Sci. (IF 4.4) Pub Date : 2024-04-05 Zeeshan Hyder, Ghazala Hafeez Rizwani, Huma Shareef, Iqbal Azhar, Meraj Zehra
DNA-based molecular markers have great importance among other methods used for the authentication, detection, and identification of medicinal herbal species. Currently, it is more common to identify the medicinal herbal species (monoherbal or polyherbal forms) morphologically by using sensory, macroscopic, and microscopic methods. DNA-based markers made an easy for accurate detection of herbal species
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Elucidation of the composition, antioxidant, and antimicrobial properties of essential oil and extract from Citrus aurantifolia (Christm.) Swingle peel Saudi J. Biol. Sci. (IF 4.4) Pub Date : 2024-04-05 Nandang Permadi, Mohamad Nurzaman, Febri Doni, Euis Julaeha
The most effective methodologies for generating spp. explants involve the utilization of plant tissue culture micropropagation techniques. However, the pervasive challenge of microbial contamination significantly impedes the successful micropropagation of spp. This study examined the antioxidant and antibacterial characteristics of the essential oil (LPO) and extract (LPE) obtained from the peel of
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Exploring the chemical characterization and insecticidal activities of Curcuma angustifolia roxb. leaf essential oils against three major stored product insects Saudi J. Biol. Sci. (IF 4.4) Pub Date : 2024-04-05 Angel Paul, Naduvilthara U. Visakh, Berin Pathrose, Nicola Mori, Rowida S. Baeshen, Rady Shawer
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Milk microbiota of Holstein Friesian cattle reared in Lahore: Association with mastitis Saudi J. Biol. Sci. (IF 4.4) Pub Date : 2024-04-03 Mian Muhammad Salman, Muhammad Nawaz, Tahir Yaqub, Muhammad Hassan Mushtaq
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Vegetation–edaphic correlation and importance value index in himalayan ‘ecotone’ temperate conifer forest using the multivariate technique Saudi J. Biol. Sci. (IF 4.4) Pub Date : 2024-03-24 F. Ali, M. Zeb, M. Amin, M.N. Rajpar, S. Hidayat, W.R. Khan
Himalayan ‘Ecotone’ temperate conifer forest is the cradle of life for human survival and wildlife existence. In spite of the importance of these areas, they have not been studied in depth. This study aimed to quantify the floristic structure, important value index (IVI), topographic and edaphic variables between 2019 and 2020 utilizing circular quadrant method (10 m x 10 m). The upper-storey layer
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Molecular detection of ruminal micro-flora and micro-fauna in Saudi Arabian camels: Effects of season and region Saudi J. Biol. Sci. (IF 4.4) Pub Date : 2024-03-23 Hashim M. Abdullah, Osama B. Mohammed, Abdullah Sheikh, Faisal Almathen, Ahmed M. Khalid, Amel O. Bakhiet, Mutassim M. Abdelrahman
This study investigated and explored the availability of micro-flora and micro-fauna in the ruminal contents of Arabian camel ()fromthreedifferent regions in Saudi Arabiaalong with twoseasons. Samples were prepared and tested by conventional polymerase chain reaction (PCR). This study confirmed that the bacterial flora were dominating over other microbes. Different results of the availability of each
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Unveiling the Tiny Invaders: A deep dive into microplastics in shrimp – Occurrence, detection and unraveling the ripple effects Saudi J. Biol. Sci. (IF 4.4) Pub Date : 2024-03-23 Amrutha Vellore Mohan, Sudhakaran Raja
Aquaculture is a rapidly expanding food sector worldwide; it is the farming of fish, shellfish, and other marine organisms. Microplastics (MPs) are small pieces of plastic with a diameter of less than 5 mm that end up in the marine environment. MPs are fragments of large plastics that take years to degrade but can frustrate into small pieces, and some commercially available MPs are used in the production
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The implication of miR-200a and miR-132 expression and their correlations with NF-κB/TNF-alpha signaling in adults with diabetic nephropathy Saudi J. Biol. Sci. (IF 4.4) Pub Date : 2024-03-16 Zienab Negeem, Adel Abdel Moneim, Basant Mahmoud, Amr E. Ahmed, Abeer M. Abd El-Hameed, Areej A. Eskandrani, Nabil A. Hasona
The primary factor causing chronic renal failure is diabetic nephropathy (DN) worldwide. However, the current biomarkers for DN have limited diagnostic utility. Thus, this work aimed to clarify the implications of microRNA-200a (miR-200a) and microRNA-132 (miR-132) and their correlation with NF-κB (nuclear factor- kappa beta), and, TNF-α (tumor necrosis factor –alpha) signaling to identify biomarkers
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Assessment of soil microbial diversity and soil enzyme activities under inorganic input sources on maize and rice ecosystems Saudi J. Biol. Sci. (IF 4.4) Pub Date : 2024-03-12 M. Jeya Bharathi, Mariyappillai Anbarasu, R. Ragu, E. Subramanian
To increase crop productivity, modern agricultural practices comprises fertilizers, algaecides, herbicides and fungicides. The purpose of this study was to evaluate the effects of soil microbial population and soil enzyme activity by the use of fertilizer in maize and inorganic input in the rice ecosystem. A field experiment (2021 to 2023) was carried out using synthetic fertilizer doses with maize
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Comparison of the first time detected Oesophagostomum asperum with Oesophagostomum columbianum in sheep and goats in Bangladesh based on the trinity: Morphology, morphometry and genetic diversity Saudi J. Biol. Sci. (IF 4.4) Pub Date : 2024-03-11 Nusrat Nowrin Shohana, Anita Rani Dey, Sharmin Aqter Rony, Shirin Akter, Bimal Chandra Karmakar, Mohammad Zahangir Alam
spp. (Family: Chabertiidae) is keeping a low profile in terms of severity in Bangladesh while maintaining economic loss through disguise within sheep and goats. The study was performed to identify prevalence, confirmation of species through morphology and morphometry followed by phylogeny using and genes. In total 384 slaughterhouse-sourced small and large intestines were pooled from Mymensingh, Kishoreganj
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Berberine modulates cardiovascular diseases as a multitarget-mediated alkaloid with insights into its downstream signals using in silico prospective screening approaches Saudi J. Biol. Sci. (IF 4.4) Pub Date : 2024-03-11 Sanaa Almowallad, Rehab Al-Massabi
Atherosclerosis is potentially correlated with several cardiac disorders that are greatly associated with cellular oxidative stress generation, inflammation, endothelial cells dysfunction, and many cardiovascular complications. Berberine is a natural isoquinoline alkaloid compound that widely modulates pathogenesis of atherosclerosis through its different curative potentials. This screening study was
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Diabetes and diabetic associative diseases: An overview of epigenetic regulations of TUG1 Saudi J. Biol. Sci. (IF 4.4) Pub Date : 2024-03-11 Mohammed Ageeli Hakami
The epigenetic regulation of lncRNA TUG1 has garnered significant attention in the context of diabetes and its associated disorders. TUG1′s multifaceted roles in gene expression modulation, and cellular differentiation, and it plays a major role in the growth of diabetes and the issues that are related to it due to pathological processes. In diabetes, aberrant epigenetic modifications can lead to dysregulation
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The antioxidant and anticancer activity of Quercus coccifera plant leaves extracts Saudi J. Biol. Sci. (IF 4.4) Pub Date : 2024-03-10 Saif Aldeen Jaber
are one of the medicinal plants that commonly used in the treatment of different diseases. () is part of the species which grow in Jordan and used in traditional folklore medicine. The aim of this study is to confirm the ability of () leaves extracts to exert anticancer activity.
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Microbiological Quality Assessment of Skin and Body care Cosmetics by using Challenge test Saudi J. Biol. Sci. (IF 4.4) Pub Date : 2024-02-28 Fatimah M. Alshehrei
Cosmetic products may be exposed to microbial contamination during storage or transport, and to avoid the risk of microbial growth, manufacturers add preservative compounds as a protection for the product from spoilage. The Microbial Challenge test is a procedure to evaluate the preservative efficacy by challenging the product with testing microorganisms to determine the quality of preservation. In
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Camel urine as a potential source of bioactive molecules showing their efficacy against pathogens: A systematic review Saudi J. Biol. Sci. (IF 4.4) Pub Date : 2024-02-25 Ressmi Amina, Raqraq Habiba, Barguigua Abouddihaj
Camels are highly suited for severe desert conditions and able to provide most of the natural products like urine, which has been used as alternative medicine to treat diverse infections and disorders. There is, however, a shortage and paucity of scientific reviews highlighting the antifungal, antibacterial and antiviral effects of camel urine. By better understanding its antimicrobial characteristics
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In vitro and in silico studies of the potential cytotoxic, antioxidant, and HMG CoA reductase inhibitory effects of chitin from Indonesia mangrove crab (Scylla serrata) shells Saudi J. Biol. Sci. (IF 4.4) Pub Date : 2024-02-25 Inarah Fajriaty, Irda Fidrianny, Neng Fisheri Kurniati, Norsyahida Mohd Fauzi, Sarmila Hanim Mustafa, I. Ketut Adnyana
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Deciphering the crosstalk between inflammation and biofilm in chronic wound healing: Phytocompounds loaded bionanomaterials as therapeutics Saudi J. Biol. Sci. (IF 4.4) Pub Date : 2024-02-23 Srivarshini Sankar, Gothandam Kodiveri Muthukaliannan
In terms of the economics and public health, chronic wounds exert a significant detrimental impact on the health care system. Bacterial infections, which cause the formation of highly resistant biofilms that elude standard antibiotics, are the main cause of chronic, non-healing wounds. Numerous studies have shown that phytochemicals are effective in treating a variety of diseases, and traditional medicinal
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Physiological responses and yield performance of selected rice (Oryza sativa L.) genotypes under deficit moisture stress Saudi J. Biol. Sci. (IF 4.4) Pub Date : 2024-02-19 Khushi Rani Das, Farhana Zaman, Md. Moshiul Islam, Sazada Siddiqui, Mohammed O. Alshaharni, Uthman Balgith Algopishi
Rice is an important food crop, while it is severely affected by drought stress. Viewing this point in mind we conducted an experiment to see the physiological responses and yield potential of selected rice genotypes under inadequate moisture condition. Two soil moisture condition: one is sufficient moisture condition (control; 95–100% field capacity (FC)) and another is deficit moisture condition
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Antibacterial and antibiofilm potentials of Rumex dentatus root extract characterized by HPLC-ESI-Q-TOF-MS Saudi J. Biol. Sci. (IF 4.4) Pub Date : 2024-02-18 Imran Khan, Uzma Khan, Wajiha Khan, Aljawharah Alqathama, Muhammad Riaz, Rizwan Ahmad, Mohammad Mahtab Alam
The control of infections is one of the key strategies to treat cuts, wounds, lung, and skin infections. In this study the folkloric use of () roots in the mentioned conditions was scientifically investigated. The methanolic (MeOH) crude extract of root was fractionated (n-hexane, ethyl acetate and water) via bioassay-guided method, and its antibacterial activity was evaluated using the agar well diffusion
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Metabolic analysis of the CAZy class glycosyltransferases in rhizospheric soil fungiome of the plant species Moringa oleifera Saudi J. Biol. Sci. (IF 4.4) Pub Date : 2024-02-18 Sahar A. Alshareef
The target of the present work is to study the most abundant carbohydrate-active enzymes (CAZymes) of glycosyltransferase (GT) class, which are encoded by fungiome genes present in the rhizospheric soil of the plant species . The datasets of this CAZy class were recovered using metagenomic whole shotgun genome sequencing approach, and the resultant CAZymes were searched against the KEGG pathway database
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Targeting XGHPRT enzyme to manage Helicobacter pylori induced gastric cancer: A multi-pronged machine learning, artificial intelligence and biophysics-based study Saudi J. Biol. Sci. (IF 4.4) Pub Date : 2024-02-18 Alhumaidi B. Alabbas
infects the stomach mucosa of over half of the global population and can lead to gastric cancer. This pathogen has demonstrated resistance to many frequently prescribed antibiotics, thereby underscoring the pressing need to identify novel therapeutic targets. The inhibition or disruption of nucleic acid biosynthesis constitutes a promising avenue for either restraining or eradicating bacterial proliferation
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Microbiological risk assessment and resistome analysis from shotgun metagenomics of bovine colostrum microbiome Saudi J. Biol. Sci. (IF 4.4) Pub Date : 2024-02-16 Muhammad Yasir, Ibrahim A. Al-Zahrani, Raees Khan, Samah Abdullah Soliman, Safaa A. Turkistani, Maha Alawi, Esam I. Azhar
Colostrum is known for its nutraceutical qualities, probiotic attributes, and health benefits. The aim of this study was to profile colostrum microbiome from bovine in rural sites of a developing country. The focus was on microbiological safety assessments and antimicrobial resistance, taking into account the risks linked with the consumption of raw colostrum. Shotgun sequencing was employed to analyze
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Diversity of endophytic fungi from medicinal plant Oxalis latifolia and their antimicrobial potential against selected human pathogens Saudi J. Biol. Sci. (IF 4.4) Pub Date : 2024-02-15 J.M. Hussein, H. Myovela, D.D. Tibuhwa
Endophytic fungi that inhabit medicinal plants are microbial resources renowned for having compounds analogous to those produced by their host plants. This study aimed to describe the diversity of endophytic fungi found in Kunth. To better understand the diversity of foliar endophytic fungi found in the leaves of the medicinal plant , we isolated and characterized endophytic by using both morphological
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Insights into cucumber (Cucumis sativus) genetics: Genome-wide discovery and computational analysis of the Calreticulin Domain-Encoding gene (CDEG) family Saudi J. Biol. Sci. (IF 4.4) Pub Date : 2024-02-13 Pravej Alam, Thamer Albalawi
Cucumber is an essential vegetable crop throughout the world. Cucumber development is vital for accomplishing both quality and productivity requirements. Meanwhile, numerous factors have resulted in substantial cucumber losses. However, the calreticulin domain-encoding genes (CDEGs) in cucumber were not well-characterized and had little function. In the genome-wide association study (GWAS), we recognized
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Preparation and evaluation of antidiabetic activity of mangiferin-loaded solid lipid nanoparticles Saudi J. Biol. Sci. (IF 4.4) Pub Date : 2024-02-08 Ahmed I. Foudah, Mohammad Ayman Salkini, Mohammed H. Alqarni, Aftab Alam
This study aimed to develop and optimize mangiferin-loaded solid lipid nanoparticles (MG-SLNs) using the microemulsion technique and ultrasonication. The MG-SLNs were composed of Labrafil M 2130 CS, MG, ethanol, Tween 80, and water. The optimized MG-SLNs exhibited a particle size of 138.37 ± 3.39 nm, polydispersity index of 0.247 ± 0.023, entrapment efficiency of 84.37 ± 2.43 %, and zeta potential
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Coproduction of alkaline protease and xylanase from genetically modified Indonesian local Bacillus halodurans CM1 using corncob as an inducing substrate Saudi J. Biol. Sci. (IF 4.4) Pub Date : 2024-02-05 I Gede Eka Perdana Putra, Maria Ulfah, Niknik Nurhayati, Is Helianti
The production of corn generates a substantial amount of agro-industrial waste, with corncob accounting for a significant portion of this waste. In this study, we focused on utilizing corncob as a carbon source and inducer to simultaneously produce two valuable industrial enzymes, protease, and xylanase, using a recombinant strain of CM1. Interestingly, xylan-rich corncob not only enhanced the xylanase
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A novel approach to insulin delivery via oral route: Milk fat globule membrane derived liposomes as a delivery vehicle Saudi J. Biol. Sci. (IF 4.4) Pub Date : 2024-01-28 Shaheer Shafiq, Maisa Siddiq Abduh, Fareeha Iqbal, Kousain Kousar, Sadia Anjum, Tahir Ahmad
The current research endeavor seeks to unlock the potential of orally administered insulin formulations by utilizing liposomes derived from the fat globule membrane (MFGM) of camel milk as carriers for insulin. This pursuit emerges as a result of the recognized limitations of subcutaneous insulin therapy. The liposomes were meticulously created using the thin film hydration method, followed by comprehensive
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Phytochemical and antimicrobial properties of different plants and in silico investigation of their bioactive compounds in wound healing and rheumatism Saudi J. Biol. Sci. (IF 4.4) Pub Date : 2024-01-28 Roheena Abdullah, Qamar Younas, Afshan Kaleem, Mehwish Iqtedar, Mahwish Aftab, Faiza Saleem
In the current study the assessment of the antimicrobial and phytochemical properties of Cassia fistula, Musa paradisiaca, Ficus religiosa and Murraya koenigii plants extracts was carried out. The antibacterial potential of these plants extracts was tested against S. aureus and E. coli. The Cassia fistula and Ficus religiosa leaves showed the larger zone of inhibition in aqueous and butanolic extract
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Genetic variability and diversity analysis in Oryza sativa L. genotypes using quantitative traits and SSR markers Saudi J. Biol. Sci. (IF 4.4) Pub Date : 2024-01-28 Adel A. Rezk, Heba I. Mohamed, Hossam S. El-Beltagi
The present study was aimed at evaluating the genetic variation and population structure in a collection of 22 rice genotypes. Twenty-two rice genotypes were assessed using quantitative traits and SSR molecular markers for genetic variability and genetic diversity. As for genetic diversity, the genotypes were clarified based on twelve quantitative traits. Clustering produced two large groups: the IR70423-169-2-2
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In-silico characterization of GABAT protein found in gut-brain axis associated bacteria of healthy individuals and multiple sclerosis patients Saudi J. Biol. Sci. (IF 4.4) Pub Date : 2024-02-02 Nadia Hussain, Fatima Muccee
Multiple sclerosis (MS) is a neurodegenerative disease characterized by inflammation and demyelination of neurons. There is evidence to suggest that level of a neurotransmitter gamma-aminobutyric acid (GABA), due to the degradation by γ-aminobutyric acid transaminase (GABAT), is reduced in certain areas of the brain in MS patients. MS is always accompanied by gut bacteria dysbiosis. In healthy individuals
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The geranium genus: A comprehensive study on ethnomedicinal uses, phytochemical compounds, and pharmacological importance Saudi J. Biol. Sci. (IF 4.4) Pub Date : 2024-01-28 Bader Alshehri
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Inter - and intraspecific phenotypic variation in co-occurring invasive and introduced cyprinid fish species Saudi J. Biol. Sci. (IF 4.4) Pub Date : 2024-01-28 Can Mert Gören, Nehir Kaymak
A species introduced outside of its native range will likely encounter unusual abiotic and biotic conditions,and may exhibit phenotypic traits that may facilitate survival and persistance. Phenotypic plasticity drives non-native species' development of adaptive traits in the new environment, increases their fitness, and as a result, contributes to invasion success. In this study, we examined inter
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Pandemic H1N1 influenza virus triggers a strong T helper cell response in human nasopharynx-associated lymphoid tissues Saudi J. Biol. Sci. (IF 4.4) Pub Date : 2024-01-28 Waleed H. Mahallawi, Omar F. Khabour
The pH1N1 belongs to influenza A family that is sometimes transmitted to humans via contact with pigs. Human tonsillar immune cells are widely used as in vitro models to study responses to influenza viruses. In the current study, human memory (M) and naïve (N) T cells responses in mononuclear cells of tonsil (TMCs) and peripheral blood (PBMCs) were stimulated by pH1N1/sH1N1, and then stained for estimation
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Analyzing bacterial persistence and dormancy: A bibliometric exploration of 21st century scientific literature Saudi J. Biol. Sci. (IF 4.4) Pub Date : 2024-01-26 Lienda Bashier Eltayeb
In response to growing concerns about the efficacy of antibiotic treatment, there has been a significant increase in research on bacteria that are resistant to antibiotics over the past two centuries. Such investigations might bring a spotlight on the field's evolution and future prospects. The study was aimed at conducting a measurable bibliometric review of the scientific literature on bacterial
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Endophytic fungi of Tradescantia pallida Mediated targeting of Multi-Drug Resistant human pathogens Saudi J. Biol. Sci. (IF 4.4) Pub Date : 2024-01-20 Ranjitha Dhevi V. Sundar, Sathiavelu Arunachalam
Antimicrobial resistance (AMR) has emerged as one of the most serious worldwide public health issues of the twenty-first century. The expeditious rise of AMR has urged the development of new, natural effective therapeutic strategies against drug-resistant pathogens. Endophytic fungi, which inhabit distinctive environments like endosymbiotic relationships with plants, are gaining interest as alternative
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Exploring the role and mechanism of potential probiotics in mitigating the shrimp pathogens Saudi J. Biol. Sci. (IF 4.4) Pub Date : 2024-01-20 Manishkumar Tamilselvan, Sudhakaran Raja
Shrimp aquaculture has rapidly developed into a significant industry worldwide, providing not only financial gain and high-quality food but also tens of thousands of trained and competent workers. Frequent diseases are now regarded as a significant risk factor for shrimp aquaculture, as they have the potential to significantly reduce shrimp production and result in economic losses. Over the years various
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Phyto-therapeutics as anti-cancer agents in breast cancer: Pathway targeting and mechanistic elucidation Saudi J. Biol. Sci. (IF 4.4) Pub Date : 2024-01-20 Abdullah Almilaibary
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Cell-free DNA as a potential diagnostic biomarker in academic stress: A case-control study in young adults Saudi J. Biol. Sci. (IF 4.4) Pub Date : 2024-01-14 Muhammad Adnan Shan, Warda Ishtiaq, Shamsa Kanwal, Muhammad Umer Khan, Ayesha Iftikhar, Samiullah Khan
Background Stress is a pervasive issue in modern life, affecting both physical and mental health. Identifying biomarkers like cell-free DNA (cfDNA) could provide insights into stress response and help detect individuals at risk for stress-related disorders. Objective The aim of this study is to investigate the potential use of cfDNA as a diagnostic biomarker in individuals experiencing stress. Methodology
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Clinical applications of artificial intelligence in identification and management of bacterial infection: Systematic review and meta-analysis Saudi J. Biol. Sci. (IF 4.4) Pub Date : 2024-01-14 Mohammad Zubair
Pneumonia is declared a global emergency public health crisis in children less than five age and the geriatric population. Recent advancements in deep learning models could be utilized effectively for the timely and early diagnosis of pneumonia in immune-compromised patients to avoid complications. This systematic review and meta-analysis utilized PRISMA guidelines for the selection of ten articles
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Improvement of renal functions in mice with septic acute kidney injury using secretome of mesenchymal stem cells Saudi J. Biol. Sci. (IF 4.4) Pub Date : 2024-01-13 Arifin Arifin, Bambang Purwanto, Dono Indarto, Brian Wasita, Tatar Sumanjar, Eti Poncorini Pamungkasari, Soetrisno Soetrisno
Background A potentially fatal complication of sepsis is septic acute kidney injury. Stem cell therapy is a potential new method of treating sepsis and has been applied to treat some human diseases. Objectives This study investigated the effects of secretome-MSCs on NGAL, CRP, NF-κB, and MMP-9 proteins, and histopathology in mice with septic AKI. Methods A post-test-only group design was conducted
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Molecular cytogenetic analysis of multi-miscarriage products of conception in clinical cases from Al-Anbar Governorate, west of Iraq Saudi J. Biol. Sci. (IF 4.4) Pub Date : 2024-01-12 Mushtak T.S. Al-Ouqaili, Rafal M. Murshid, Basma Y. Abd Al-Kariem, Bushra A. Kanaan, Ahmed T.S. Al-Neda
Most clinical miscarriages often occur throughout the first trimester of pregnancy, with fetal chromosomal abnormalities being identified as the primary reason for such occurrences. The objective is to analyze the fetal chromosomal aberrations in the product of conception among Iraqi patients suffering from recurrent miscarriages. The cross-sectional study was performed on 60 cases of products of conception
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Biochar-based organic fertilizers: Influence on yield and concentration of antioxidants in the stigma of saffron and rhizosphere bacterial diversity of slightly saline and non-saline soils Saudi J. Biol. Sci. (IF 4.4) Pub Date : 2024-01-05 Shagufta Qasim, Shamim Gul, Abdul Hanan Buriro, Fahad Shafiq, Tariq Ismail
Being the most expensive spice, saffron has great economic importance. This crop grows well in cold arid deserts. Salinity is one of the important limiting factors for the cultivation of this crop. However, the use of composted manured and co-composted biochar and fertilizers can play a role in attenuating the salinity stress on this crop. In this two-year field study, manures from three sources: sheep
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Alleviation of carbendazim toxicity effect by Moringa oleifera oil and Linum usitatissimum L. oil on testes of male rats: Physiological, histological and in silico study Saudi J. Biol. Sci. (IF 4.4) Pub Date : 2023-12-30 Muhammad Hashim, Atef M. Al-Attar, Mohammed Y. Alomar, Abdulkader M. Shaikh Omar, Naser A. Alkenani, Isam M. Abu Zeid
Carbendazim (CBZ) is a widely used fungicide that is used to control the unwanted growth of fungi on fruits and vegetables. Sixty male rats were divided into six groups, each having ten. Group one served as control, animals belonging to group two were exposed to CBZ in the measure of 200 mg/kg body weight (BW). In the third and fourth groups, rats were administered 800 mg/kg BW of Moringa oleifera
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An overview of multiple myeloma: A monoclonal plasma cell malignancy’s diagnosis, management, and treatment modalities Saudi J. Biol. Sci. (IF 4.4) Pub Date : 2023-12-30 Maisa Siddiq Abduh
Multiple Myeloma (MM) is a plasma cell cancer with high mortality and morbidity rates. Its incidence rate has increased by 143% since 1975. Adipokines, cytokines, chemokines, and genetic variations influence the development and progression of MM. Chromosomal translocations cause mutations associated with MM. The pathogenesis of MM is complicated by novel issues like miRNAs, RANKL, Wnt/DKK1, Wnt, and
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Integrative analysis of RNA expression data unveils distinct cancer types through machine learning techniques Saudi J. Biol. Sci. (IF 4.4) Pub Date : 2023-12-30 Saad Awadh Alanazi, Nasser Alshammari, Maddalah Alruwaili, Kashaf Junaid, Muhammad Rizwan Abid, Fahad Ahmad
Cancer is a highly complex and heterogeneous disease. Traditional methods of cancer classification based on histopathology have limitations in guiding personalized prognosis and therapy. Gene expression profiling provides a powerful approach to unraveling molecular intricacies and better-stratifying cancer subtypes. In this study, we performed an integrative analysis of RNA sequencing data from five
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Clinicopathological Significance and Expression Pattern of Bcl2 in Breast Cancer: A Comprehensive in silico and in vitro Study Saudi J. Biol. Sci. (IF 4.4) Pub Date : 2023-12-23 Shazia sofi, Umar Mehraj, Nusrat Jan, Abdullah Almilaibary, Irshad Ahmad, Fuzail Ahmad, Manzoor Ahmad Mir
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Diversity, Distribution, and applications of arbuscular mycorrhizal fungi in the Arabian Peninsula Saudi J. Biol. Sci. (IF 4.4) Pub Date : 2023-12-25 Khazna Alrajhi, Shazia Bibi, Mohammed Abu-Dieyeh
Investigations of arbuscular mycorrhizal fungi (AMF) received extreme interests among scientist including agronomists and environmental scientists. This interest is linked to advantages provided by AMF in enhancing the nutrients of their hosts via improving photosynthetic pigments and antioxidant production. Further, it also positively alters the production of plant hormones. AMF through its associations
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Association of genetic predisposition studies in CYP1A1 polymorphism studies in acute myeloid leukemia Saudi J. Biol. Sci. (IF 4.4) Pub Date : 2023-12-23 Abdullah Farasani
Cytochrome P450 Family 1 Subfamily A Member 1 (CYP1A1) gene is one of the sub-members of CYP450 family member and it encodes with the families of drug metabolizing enzyme families along with the cancers and leukemias. Among leukemias, AML is considered to be one of the important leukemia which attack the older adults. The aim of this study is to explore the role of A4889G polymorphism in CYP1A1 gene
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Stegomyia indices and pattern recognition of Aedes aegypti (Diptera: Culicidae) in selected agrogeoclimatic zones of Punjab, Pakistan Saudi J. Biol. Sci. (IF 4.4) Pub Date : 2023-12-23 Muhammad Abdullah Malik, Muhammad Sohail Sajid, Rasha Khalifah Al-Akeel, Mughees Aizaz Alvi, Hafiz Muhammad Rizwan, Haider Abbas, Mahvish Maqbool
Mosquito-borne diseases especially, dengue is gaining currency nowadays in Pakistan. As there is no approved dengue vaccine available worldwide, prevention and control of vector is the only solution amid prevailing circumstances. The present study is a maiden attempt to screen indoor and outdoor breeding containers for the presence of Aedes (Ae.) aegypti larvae from selected study districts of Punjab
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Biochemical characterization of chamomile essential oil: Antioxidant, antibacterial, anticancer and neuroprotective activity and potential treatment for Alzheimer's disease Saudi J. Biol. Sci. (IF 4.4) Pub Date : 2023-12-16 Nada F. Alahmady, Fadwa M. Alkhulaifi, Maha Abdullah Momenah, Asmaa Ali Alharbi, Aminah Allohibi, Nouf H. Alsubhi, Wafaa Ahmed Alhazmi
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Identification of polymorphic alleles in TERC and TERT gene reprogramming the telomeres of newborn and legacy with parental health Saudi J. Biol. Sci. (IF 4.4) Pub Date : 2023-12-12 Sadia farrukh, Saeeda Baig, Rubina Hussain, Rehan Imad, Ome kulsoom, Mehreen Yousaf Rana
Telomere and telomerase genes (TERC and TERT) highlighted many novel genetic polymorphisms related to common diseases. This study explored the polymorphic alleles of TERC and TERT gene in parents-newborn (triad) and its association with telomere length (TL) and parental diseases (mother: Gestational Diabetes Mellitus (GDM), Preeclampsia, fathers: Diabetes, Hypertension). In this cross-sectional study
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Examining the varied concentrations of Mentha spicata and Ocimum basilicum affect the synthesis of AgNPs that restrict the development of bacteria Saudi J. Biol. Sci. (IF 4.4) Pub Date : 2023-12-10 Motahher A. Qaeed
This work examined the effects of varied concentrations of Ocimum basilicum and Mentha spicata aqueous extracts in order to determine the concentration that has the strongest antibacterial impact through the green synthesis technique of silver nanoparticles (AgNPs). In order to synthesize AgNPs using the reduction method, different quantities of reducing and stabilizing agents: (a) 0.75 mM Ocimum basilicum
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Isolation, characterization, and cloning of thermostable pullulanase from Geobacillus stearothermophilus ADM-11 Saudi J. Biol. Sci. (IF 4.4) Pub Date : 2023-12-10 Dilara Abbas Bukhari, Zuhra Bibi, Arif Ullah, Abdul Rehman
This study aimed to identify thermo-stable pullulanase-producing bacteria in soil samples of potato fields and food-producing companies. Pullulan agar medium was used to screen 17 bacterial strains, which were incubated at 65 °C. The isolate with the maximum activity (375U/ml) was selected and recognized as Geobacillus stearothermophilus ADM-11 by morphological, biochemical characterization, and 16S
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Vitamin E reduces oxidative stress in brains of male albino male rats undergoing immobilization Saudi J. Biol. Sci. (IF 4.4) Pub Date : 2023-12-10 Noorah Saleh Al-Sowayan, Reem Abdullah Almarzougi
Stress can lead to various health problems. Exposure to stress is linked to several diseases including cancer, hypertension, diabetes, mental disorders, and heart attacks. Stress stimulates several pathways that produce free radicals, which increases oxidative stress. This results in functional and structural damage to organs, such as the brain, which is highly sensitive to oxidative stress Vitamin