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Benign metastasizing fumarate hydratase (FH)-deficient uterine leiomyomas: clinicopathological and molecular study with first documentation of multi-organ metastases Virchows Arch. (IF 3.5) Pub Date : 2024-04-20 Xiaoxue Yin, Xiaoxia Wei, Ruqaiya Al Shamsi, Fatima S. Ali, Faiza Al Kindi, Xingming Zhang, Jiayu Liang, Xiuyi Pan, Mohammed Al Masqari, Linmao Zheng, Qiao Zhou, Abbas Agaimy, Ni Chen
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Atrophic changes in thyroid tumors are strong indicators of underlying DICER1 mutations: a bi-institutional genotype–phenotype correlation study Virchows Arch. (IF 3.5) Pub Date : 2024-04-19 Vincenzo Condello, James W. Roberts, Adam Stenman, Catharina Larsson, Kartik Viswanathan, C. Christofer Juhlin
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Metastatic cutaneous squamous cell carcinoma accounts for nearly all squamous cell carcinomas of the parotid gland Virchows Arch. (IF 3.5) Pub Date : 2024-04-17 Patrick J. Bradley, Göran Stenman, Lester D. R. Thompson, Alena Skálová, Roderick H. W. Simpson, Pieter J. Slootweg, Alessandro Franchi, Nina Zidar, Alfons Nadal, Henrik Hellquist, Michelle D. Williams, Ilmo Leivo, Abbas Agaimy, Alfio Ferlito
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Evaluation of the prognostic potential of histopathological subtyping in high-grade serous ovarian carcinoma Virchows Arch. (IF 3.5) Pub Date : 2024-04-16 Hein S. Zelisse, Robin A. Hwan, Marc J. van de Vijver, Frederike Dijk, Constantijne H. Mom, Gerrit K. J. Hooijer, Mignon D. J. M. van Gent, Malou L. H. Snijders
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Familial syndromes associated with testicular and paratesticular neoplasms: a comprehensive review Virchows Arch. (IF 3.5) Pub Date : 2024-04-15 Andrea Strakova-Peterikova, Maryna Slisarenko, Josef Skopal, Kristyna Pivovarcikova, Tomas Pitra, Mihaela Farcas, Michael Michal, Michal Michal, Kvetoslava Michalova
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POU2F3-expressing intraepithelial small-cell carcinoma with mixed small-cell carcinoma and conventional-type urothelial carcinoma of the urinary bladder Virchows Arch. (IF 3.5) Pub Date : 2024-04-11 Laurence A. Galea, Ahida Batrouney, Maria Flynn, Michael Christie
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CCN2/CTGF expression does not correlate with fibrosis in myeloproliferative neoplasms, consistent with noncanonical TGF-β signaling driving myelofibrosis Virchows Arch. (IF 3.5) Pub Date : 2024-04-11 Roos J. Leguit, Roel Broekhuizen, Moniek de Witte, Reinier A. P. Raymakers, Roel Goldschmeding
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Scoring PD-L1 Expression in Urothelial Carcinoma: An International Multi-Institutional Study on Comparison of Manual and Artificial Intelligence Measurement Model (AIM-PD-L1) Pathology Assessments Virchows Arch. (IF 3.5) Pub Date : 2024-04-04 Josef Rüschoff, George Kumar, Sunil Badve, Bharat Jasani, Emma Krause, Nathalie Rioux-Leclercq, Federico Rojo, Maurizio Martini, Liang Cheng, Maria Tretiakova, Catherine Mitchell, Robert A. Anders, Marie E. Robert, Darren Fahy, Mike Pyle, Quang Le, Limin Yu, Benjamin Glass, Vipul Baxi, Zulfia Babadjanova, James Pratt, Sergine Brutus, Maria Karasarides, Arndt Hartmann
Assessing programmed death ligand 1 (PD-L1) expression on tumor cells (TCs) using Food and Drug Administration-approved, validated immunoassays can guide the use of immune checkpoint inhibitor (ICI) therapy in cancer treatment. However, substantial interobserver variability has been reported using these immunoassays. Artificial intelligence (AI) has the potential to accurately measure biomarker expression
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N-myc downstream–regulated gene 1 can promote vasculogenic mimicry and angiogenesis in urothelial carcinoma Virchows Arch. (IF 3.5) Pub Date : 2024-04-02
Abstract Urothelial carcinoma (UC) of the bladder is a common cause of cancer-related death worldwide. Vasculogenic mimicry (VM) is a process by which the malignant cells can generate vascular-like structures formed of periodic acid–Schiff (PAS) positive/CD31 negative extracellular matrix independent of angiogenesis and thus promotes tumor progression. N-myc downstream–regulated gene 1 (NDRG1) is a
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Nuclear morphological atypia in biopsy accurately reflects the prognosis of myxoid liposarcoma Virchows Arch. (IF 3.5) Pub Date : 2024-03-28
Abstract Currently, it is difficult to predict the prognosis of myxoid liposarcoma (MLS) in biopsy specimens. In this study, we determined whether nuclear morphology may be used to predict the prognosis of MLS in primary biopsy specimens. Two pathologists evaluated nuclear morphology using the modified WHO/ISUP and Fuhrman grades. Survival analyses were performed by grouping nuclear high- and low-grades
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Expression of fibroblast growth factor receptor 2 (FGFR2) in combined hepatocellular-cholangiocarcinoma and intrahepatic cholangiocarcinoma: clinicopathological study Virchows Arch. (IF 3.5) Pub Date : 2024-03-27 Motoko Sasaki, Yasunori Sato, Yasuni Nakanuma
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Digital counting of tissue cells for molecular analysis: the QuANTUM pipeline Virchows Arch. (IF 3.5) Pub Date : 2024-03-26 Vincenzo L’Imperio, Giorgio Cazzaniga, Mauro Mannino, Davide Seminati, Francesco Mascadri, Joranda Ceku, Gabriele Casati, Francesca Bono, Catarina Eloy, Elena Guerini Rocco, Chiara Frascarelli, Matteo Fassan, Umberto Malapelle, Fabio Pagni
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Primary mismatch repair–deficient prostate cancer can be identified prospectively in prostate biopsies and radical prostatectomies Virchows Arch. (IF 3.5) Pub Date : 2024-03-26 Andres M. Acosta
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COVID-19-associated secondary sclerosing cholangitis with liver transplantation Virchows Arch. (IF 3.5) Pub Date : 2024-03-25
Abstract We report on two cases of orthotopic liver transplantation (OLTX) due to SARS-Cov2-associated secondary sclerosing cholangitis (SSC) following long-term artificial respiration and extra-corporal membrane oxygenation in intensive care. Under these conditions, SSC is a rapidly progredient biliary disease featuring degenerative cholangiopathy, loss of bile ducts, ductular and parenchymal cholestasis
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The pattern-based interpretation of p53 immunohistochemical expression as a surrogate marker for TP53 mutations in colorectal cancer Virchows Arch. (IF 3.5) Pub Date : 2024-03-21 Mitsumasa Osakabe, Noriyuki Yamada, Ryo Sugimoto, Noriyuki Uesugi, Eiichi Nakao, Michitaka Honda, Naoki Yanagawa, Tamotsu Sugai
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DNA methylation profiling identifies epigenetic signatures of early gastric cancer Virchows Arch. (IF 3.5) Pub Date : 2024-03-20 Zhongyue Shi, Xinmeng Guo, Xiumei Hu, Ruiqi Li, Xue Li, Jun Lu, Mulan Jin, Xingran Jiang
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Perinatal arterial ischemic stroke: how informative is the placenta? Virchows Arch. (IF 3.5) Pub Date : 2024-03-19 Jessica Hirschel, Francisca Barcos-Munoz, François Chalard, Florence Chiodini, Manuella Epiney, Joel Fluss, Anne-Laure Rougemont
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Breast tissue imaging atlas using ultra-fast confocal microscopy to identify cancer lesions Virchows Arch. (IF 3.5) Pub Date : 2024-03-19 Marie-Christine Mathieu, Moira Ragazzi, Malek Ferchiou, Paul J. van Diest, Odile Casiraghi, Aicha Ben Lakhdar, Nizar Labaied, Angelica Conversano, Muriel Abbaci
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P53 Overexpression May Represent an Early Marker of Clinicopathologic Progression in Vasculogenic Mesenchymal Lesions of Germ Cell Tumor Origin Virchows Arch. (IF 3.5) Pub Date : 2024-03-19
Abstract Vasculogenic mesenchymal lesions (VMLs) of germ cell tumor origin are thought to originate in postpubertal-type yolk sac tumor components and include a spectrum of lesions from teratoma with vasculogenic stroma (TVS), to low and high-grade vasculogenic mesenchymal tumors (VMTs). VMLs exhibit rudimentary to well-developed neoplastic vessels within primitive mesenchyme, being considered a neoplastic
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Utility of LEF1 to differentiate desmoid fibromatosis from its histologic mimics Virchows Arch. (IF 3.5) Pub Date : 2024-03-19
Abstract Diagnosis of desmoid-type fibromatosis (DF) may be challenging on biopsy due to morphologic overlap with reactive fibrosis (scar) and other uniform spindle cell neoplasms. Evaluation of nuclear β-catenin, a surrogate of Wnt pathway activation, is often difficult in DF due to weak nuclear expression and high background membranous/cytoplasmic staining. Lymphoid enhancer-factor 1 (LEF1) is a
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Prognostic implications of tumor histology and microenvironment in surgically resected intrahepatic cholangiocarcinoma: a single institutional experience Virchows Arch. (IF 3.5) Pub Date : 2024-03-19 Irene Y. Chen, Richard F. Dunne, Xiaoyan Liao
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Multicenter evaluation of an automated, multiplex, RNA-based molecular assay for detection of ALK, ROS1, RET fusions and MET exon 14 skipping in NSCLC Virchows Arch. (IF 3.5) Pub Date : 2024-03-16
Abstract The current study assessed the performance of the fully automated RT-PCR-based Idylla™ GeneFusion Assay, which simultaneously covers the advanced non-small cell lung carcinoma (aNSCLC) actionable ALK, ROS1, RET, and MET exon 14 rearrangements, in a routine clinical setting involving 12 European clinical centers. The Idylla™ GeneFusion Assay detects fusions using fusion-specific as well as
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Molecularly defined sinonasal malignancies: an overview with focus on the current WHO classification and recently described provisional entities Virchows Arch. (IF 3.5) Pub Date : 2024-03-16 Alena Skálová, Abbas Agaimy, Martina Bradova, Vincent Vander Poorten, Ehab Hanna, Orlando Guntinas-Lichius, Alessandro Franchi, Henrik Hellquist, Roderick H. W. Simpson, Fernando Lopéz, Sandra Nuyts, Carlos Chiesa-Estomba, Sweet Ping Ng, Akihiro Homma, Yong Teng, Ilmo Leivo, Alfio Ferlito
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Clinical significance of location of perineural cancer invasion detected on prostate needle core biopsy Virchows Arch. (IF 3.5) Pub Date : 2024-03-15 Benjamin G. Gertsen, Yuki Teramoto, Ying Wang, Toyonori Tsuzuki, Hiroshi Miyamoto
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Epidermodysplasia verruciformis–associated eccrine neoplasm: a rare entity with distinctive clinical and histopathologic features Virchows Arch. (IF 3.5) Pub Date : 2024-03-14 Eleanor Russell-Goldman, Esther Baranov, Stephanie Siegmund, Catherine S. Yang, Alvaro C. Laga, John Hanna
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The diagnostic utility of cytology specimen in a case of EWSR1::NFATC2 sarcoma Virchows Arch. (IF 3.5) Pub Date : 2024-03-14 Naoki Takeda, Naohiro Makise, Hajime Kageyama, Tsukasa Takahashi, Hiroshi Katoh, Akiko Odaka, Mariko Oikawa, Takahiro Sugiyama, Hidetada Kawana, Akinobu Araki, Hideyuki Kinoshita, Yoko Hagiwara, Hiroto Kamoda, Tsukasa Yonemoto, Makiko Itami
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Predominance of T-bet-positive Th1 cells in infiltrating T-lymphocytes in most of active arteritis lesions of giant cell arteritis Virchows Arch. (IF 3.5) Pub Date : 2024-03-13 Hidetoshi Satomi, Mikiko Kobayashi, Ichiro Ito, Koji Asano, Mutsuki Makino, Kenji Kawaguchi, Hiroyuki Kanno
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Flanagan’s condensed protocol for neurodegenerative diseases. Implementation in a clinical autopsy setting with partial supervision of a neuropathologist Virchows Arch. (IF 3.5) Pub Date : 2024-03-12 Aitana López, Samuel López-Muñoz, Gabriela Caballero, Natalia Castrejon, Leonardo Rojo, Nuria Vidal-Robau, Abel Muñoz, Estrella Ortiz, Maite Rodrigo, Adriana García, Miriam Cuatrecasas, Teresa Ribalta, Iban Aldecoa
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Clinicopathological analysis of thyroid carcinomas with the RET and NTRK fusion genes: characterization for genetic analysis Virchows Arch. (IF 3.5) Pub Date : 2024-03-12 Yoichiro Okubo, Soji Toda, Mei Kadoya, Shinya Sato, Emi Yoshioka, Chie Hasegawa, Kyoko Ono, Kota Washimi, Tomoyuki Yokose, Yohei Miyagi, Katsuhiko Masudo, Hiroyuki Iwasaki, Hiroyuki Hayashi
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Mutational, immune microenvironment, and clinicopathological profiles of diffuse large B-cell lymphoma and follicular lymphoma with BCL6 rearrangement Virchows Arch. (IF 3.5) Pub Date : 2024-03-11
Abstract BCL6-rearrangement (BCL6-R) is associated with a favorable prognosis of follicular lymphoma (FL), but the mechanism is unknown. We analyzed the clinicopathological, immune microenvironment (immune checkpoint, immuno-oncology markers), and mutational profiles of 10 BCL6-R-positive FL, and 19 BCL6-R-positive diffuse large B-cell lymphoma (DLBCL) cases (both BCL2-R and MYC-R negative). A custom-made
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Molecular diagnostics of hepatobiliary and pancreatic neoplasias Virchows Arch. (IF 3.5) Pub Date : 2024-03-01 T. Longerich, A. Stenzinger, P. Schirmacher
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Correction to: Practical guidelines of the EOTTD for pathological and genetic diagnosis of hydatidiform moles Virchows Arch. (IF 3.5) Pub Date : 2024-02-29 Carla Bartosch, Alfons Nadal, Ana C. Braga, Angela Salerno, Anne‑Laure Rougemont, Anne‑Sophie Van Rompuy, Brendan Fitzgerald, Caroline Joyce, Fabienne Allias, Geoffrey J. Maher, Gitta Turowski, Jean‑Christophe Tille, Kinan Drak Alsibai, Koen Van de Vijver, Lesley McMahon, Lone Sunde, Michal Pyzlak, Paul Downey, Sandra Wessman, Sophie Patrier, Baljeet Kaur, Rosemary Fisher
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Ovarian endometrioid carcinoma with a sex cord-like pattern: a morphological, immunohistochemical, and molecular analysis Virchows Arch. (IF 3.5) Pub Date : 2024-02-29 Antonio Travaglino, Damiano Arciuolo, Angela Santoro, Caterina Fulgione, Alessia Piermattei, Manuela Martinelli, Maria Elisabetta Onori, Angelo Minucci, Antonio Raffone, Frediano Inzani, Gian Franco Zannoni
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COVID-19 in the Netherlands: lessons from a nationwide query of dutch autopsy, histology, and cytology pathological reports Virchows Arch. (IF 3.5) Pub Date : 2024-02-27 Boaz Lopuhaä, Q. J. M. Voorham, Folkert J. van Kemenade, Jan H. von der Thüsen
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Granulation tissue-like spindle cell (sarcomatoid) carcinoma of the head and neck: a deceptively bland-looking underdiagnosed malignancy Virchows Arch. (IF 3.5) Pub Date : 2024-02-26 Alessandro Franchi, Abbas Agaimy
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Inflammatory/juvenile-like polyps in neurofibromatosis type 1 associated with epithelial dysplasia Virchows Arch. (IF 3.5) Pub Date : 2024-02-24 Diana Enea, Xavier Dray, Erell Guillerm, Antoine Guilloux, Matthieu Yver, Pascale Cervera, Magali Svrcek
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Poorly differentiated thyroid carcinomas: conceptual controversy and clinical impact Virchows Arch. (IF 3.5) Pub Date : 2024-02-24 Andrés Coca-Pelaz, Juan P. Rodrigo, Abbas Agaimy, Michelle D. Williams, Nabil F. Saba, Sandra Nuyts, Gregory W. Randolph, Fernando López, Vincent Vander Poorten, Luiz P. Kowalski, Francisco J. Civantos, Mark E. Zafereo, Antti A. Mäkitie, Oded Cohen, Iain J. Nixon, Alessandra Rinaldo, Alfio Ferlito
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Update on olfactory neuroblastoma Virchows Arch. (IF 3.5) Pub Date : 2024-02-22 Fernando Lopez, Abbas Agaimy, Alessandro Franchi, Carlos Suárez, Vincent Vander Poorten, Antti A. Mäkitie, Akihiro Homma, Avraham Eisbruch, Kerry D. Olsen, Nabil F. Saba, Sandra Nuyts, Carl Snyderman, Jonathan J. Beitler, June Corry, Ehab Hanna, Henrik Hellquist, Alessandra Rinaldo, Alfio Ferlito
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Increased expression of CD70 in relapsed acute myeloid leukemia after hypomethylating agents Virchows Arch. (IF 3.5) Pub Date : 2024-02-22 Mario L. Marques-Piubelli, Bijender Kumar, Rafet Basar, Siler Panowski, Surabhi Srinivasan, Kevin Norwood, Sacha Prashad, Victoria Szenes, Arun Balakumaran, Akanksha Arandhya, Wei Lu, Khaja Khan, Daniela Duenas, Salome McAllen, Javier A Gomez, Jared K. Burks, Sunil Acharyal, Gautam Borthakur, Wei-Lien Wang, Wei Wang, Sa Wang, Luisa M. Solis, David Marin, Katayoun Rezvani, May Daher, Francisco Vega
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Biphasic papillary (biphasic squamoid alveolar) renal cell carcinoma: a clinicopathologic and molecular study of 17 renal cell carcinomas including 10 papillary adenomas Virchows Arch. (IF 3.5) Pub Date : 2024-02-22 Luiz M. Nova-Camacho, Andres M. Acosta, Mahmut Akgul, Angel Panizo, Laurence A. Galea, Andrea Val-Carreres, Juan A. Talavera, David Guerrero-Setas, Maialen Martin-Arruti, Irune Ruiz, María García-Martos, Ankur R. Sangoi
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Tumor stroma ratio, tumor stroma maturity, tumor-infiltrating immune cells in relation to prognosis, and neoadjuvant therapy response in esophagogastric junction adenocarcinoma Virchows Arch. (IF 3.5) Pub Date : 2024-02-21
Abstract Accurate predictions on prognosis and neoadjuvant therapy response are crucial for esophagogastric junction adenocarcinoma (EGJA) patients. Therefore, we aimed to investigate the predictive abilities of several indicators, including tumor stroma ratio (TSR), tumor stroma maturity (TSM), and the density and spatial distribution of tumor-infiltrating immune cells (TIICs), such as T cells, B
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Myeloid sarcoma with RBM15::MRTFA (MKL1) mimicking vascular neoplasm Virchows Arch. (IF 3.5) Pub Date : 2024-02-20
Abstract Extramedullary involvement of acute myeloid leukemia (AML), aka myeloid sarcoma, is a rare phenomenon in acute megakaryoblastic leukemia with RBM15:: MRTFA(MKL1) fusion, which might mimic non-hematologic malignancies. A 7-month-old infant presented with leukocytosis, hepatosplenomegaly, multiple lymphadenopathies, and a solid mass in the right thigh. Initially, the patient was diagnosed with
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Exploring the histogenesis of STK11 adnexal tumour using electron microscopy Virchows Arch. (IF 3.5) Pub Date : 2024-02-20 Nuria Mascaro, Lamia Sabry Aboelnasr, Motasim Masood, Ernesto Yague, Linda Moran, Mona El-Bahrawy
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Differentiating BRAF V600E- and RAS-like alterations in encapsulated follicular patterned tumors through histologic features: a validation study Virchows Arch. (IF 3.5) Pub Date : 2024-02-16
Abstract Differentiating BRAF V600E- and RAS-altered encapsulated follicular-patterned thyroid tumors based on morphology remains challenging. This study aimed to validate an 8-score scale nuclear scoring system and investigate the importance of nuclear pseudoinclusions (NPIs) in aiding this differentiation. A cohort of 44 encapsulated follicular-patterned tumors with varying degrees of nuclear atypia
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Optimizing the management of thyroid specimens to efficiently generate whole slide images for diagnosis Virchows Arch. (IF 3.5) Pub Date : 2024-02-14
Abstract Transition from optical to digital observation requires an additional procedure in the pathology laboratory, the scanning of glass slides, leading to increased time and digital archive consumption. Thyroid surgical samples often carry the need to collect several tissue fragments that generate many slides to be scanned. This study evaluated the impact of using different inking colours for the
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Extraskeletal chondroma of the toe in a child with DICER1 tumor predisposition syndrome: support for a dominant negative mechanism Virchows Arch. (IF 3.5) Pub Date : 2024-02-14 Dylan Pelletier, Nelly Sabbaghian, Anne-Laure Chong, John R. Priest, Yomna Elsheikh Ahmed, Gabriel P. Fox, Marc R. Fabian, William D. Foulkes
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Loss of or decrease in CD30 expression in four patients with anaplastic large cell lymphoma after brentuximab vedotin-containing therapy Virchows Arch. (IF 3.5) Pub Date : 2024-02-13 Yuto Kaimi, Yuka Takahashi, Hirokazu Taniguchi, Tetsuro Ochi, Haruhi Makino, Shinichi Makita, Noriko Iwaki, Suguru Fukuhara, Wataru Munakata, Chitose Ogawa, Koji Izutsu, Akiko Miyagi Maeshima
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Heterogeneity of molecular subtyping and therapy-related marker expression in primary tumors and paired lymph node metastases of small cell lung cancer Virchows Arch. (IF 3.5) Pub Date : 2024-02-13 Yanli Zhu, Wenhao Ren, Sheng Li, Jianghua Wu, Xiao Hu, Haiyue Wang, Kaiwen Chi, Minglei Zhuo, Dongmei Lin
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Comparative epigenomics indicate a common origin of ectopic and intrasellar corticotroph pituitary neuroendocrine tumors/adenomas: a case report Virchows Arch. (IF 3.5) Pub Date : 2024-02-12 Alonso Barrantes-Freer, Max Braune, Benjamin Sandner, Matthias Dottermusch, Dirk Lindner
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Small cell osteosarcoma versus fusion-driven round cell sarcomas of bone: retrospective clinical, radiological, pathological, and (epi)genetic comparison with clinical implications Virchows Arch. (IF 3.5) Pub Date : 2024-02-09 Laura S. Hiemcke-Jiwa, Vaiyapuri P. Sumathi, Daniel Baumhoer, Stephanie E. Smetsers, Lianne M. Haveman, Max M. van Noesel, Kirsten van Langevelde, Arjen H. G. Cleven, Michiel A. J. van de Sande, Simone A. J. ter Horst, Lennart A. Kester, Uta Flucke
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Deep learning model to differentiate Crohn’s disease from intestinal tuberculosis using histopathological whole slide images from intestinal specimens Virchows Arch. (IF 3.5) Pub Date : 2024-02-08
Abstract Crohn’s disease (CD) and intestinal tuberculosis (ITB) share similar histopathological characteristics, and differential diagnosis can be a dilemma for pathologists. This study aimed to apply deep learning (DL) to analyze whole slide images (WSI) of surgical resection specimens to distinguish CD from ITB. Overall, 1973 WSI from 85 cases from 3 centers were obtained. The DL model was established
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Pigmented dentinogenic ghost cell tumor: a unique case report and a review of the literature Virchows Arch. (IF 3.5) Pub Date : 2024-02-07 Yassmin Abdalla Mustafa Mohamed, Mohamed Mogahid Abdelrahman Yousif, Nazik Omer Elbashir, Abeer Hemedan Mohammed Ahmed, Ahmed Eltayeb Ali, Ahmed Mohamed Suleiman
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Spatial expression of claudin 18.2 in matched primaries and metastases of tubo-ovarian carcinoma of all subtypes Virchows Arch. (IF 3.5) Pub Date : 2024-02-07 Paul Wagner, Paul Gass, Patrik Pöschke, Markus Eckstein, Laura Gloßner, Arndt Hartmann, Matthias Wilhelm Beckmann, Peter Andreas Fasching, Matthias Ruebner, Julius Emons, Ramona Erber
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Molecular pathological classification of colorectal cancer—an update Virchows Arch. (IF 3.5) Pub Date : 2024-02-06
Abstract Colorectal cancer (CRC) has a broad range of molecular alterations with two major mechanisms of genomic instability (chromosomal instability and microsatellite instability) and has been subclassified into 4 consensus molecular subtypes (CMS) based on bulk RNA sequence data. Here, we update the molecular pathological classification of CRC with an overview of more recent bulk and single-cell
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IgG4-related disease: an update on pathology and diagnostic criteria with a focus on salivary gland manifestations Virchows Arch. (IF 3.5) Pub Date : 2024-02-05 Agata Czarnywojtek, Abbas Agaimy, Krzysztof Pietrończyk, Iain J. Nixon, Vincent Vander Poorten, Antti A. Mäkitie, Mark Zafereo, Ewa Florek, Nadia Sawicka-Gutaj, Marek Ruchała, Alfio Ferlito
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Mallory-Denk bodies and hepatocellular senescence: a causal relationship? Virchows Arch. (IF 3.5) Pub Date : 2024-01-30 Helmut Denk, Peter M. Abuja, Kurt Zatloukal
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Histopronostic factors in superficial colorectal adenocarcinomas treated by endoscopy: reproducibility and impact of immunohistochemistry and digital pathology Virchows Arch. (IF 3.5) Pub Date : 2024-01-26 Guillaume Pontarollo, Maxime Bonjour, Thomas Walter, Mathieu Pioche, Pierre-Marie Lavrut, Maud Rabeyrin, Valérie Hervieu, Tanguy Fenouil
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Grade group 4 prostate cancer without intraductal carcinoma on biopsy is more likely to be downgraded on prostatectomy than with intraductal carcinoma Virchows Arch. (IF 3.5) Pub Date : 2024-01-25 Levent Trabzonlu, Thanchanok Chaiprasit, Andreas Kontosis, Maria Picken
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Gastroblastoma with a novel ACTB::GLI1 gene fusion in a 19-year-old male Virchows Arch. (IF 3.5) Pub Date : 2024-01-23 Junaid Shabbir, Jonathan Earle, Krzysztof Glomski, Laila Mnayer, Bret Schipper, Saverio Ligato
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Syndromic MEN1 parathyroid adenomas consist of both subclonal nodules and clonally independent tumors Virchows Arch. (IF 3.5) Pub Date : 2024-01-20 Konstantin Bräutigam, Cédric Nesti, Philipp Riss, Christian Scheuba, Bruno Niederle, Tobias Grob, Annunziata Di Domenico, Maja Neuenschwander, Peter Mazal, Nastassja Köhn, Roman Trepp, Aurel Perren, Reto M. Kaderli