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Efficacy of verbal suggestion, verbal suggestion with a tuning fork, and verbal suggestion with a cotton swab for inducing the paroxysmal event during video-EEG recording in children with suspected psychogenic nonepileptic seizures Epilepsy Behav. (IF 2.6) Pub Date : 2024-04-30 Prateek Kumar Panda, Sachendra Badal, Vivek Sirolia, Indar Kumar Sharawat, Biswaroop Chakrabarty, Prashant Jauhari, Sheffali Gulati
Video-electroencephalogram (EEG) with suggestion is widely considered the gold standard for diagnosing psychogenic nonepileptic seizures (PNES). However, ethical concerns and uncertainties persist regarding the most minimally invasive and least deceptive suggestion approach. In an open-label randomized controlled trial, we evaluated the effectiveness of three suggestion methods (verbal suggestion,
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Caregiver perceptions of the impact of Dravet syndrome on the family, current supports and hopes and fears for the future: A qualitative study Epilepsy Behav. (IF 2.6) Pub Date : 2024-04-30 Josefin Soto Jansson, Björn Bjurulf, Michaela Dellenmark Blom, Tove Hallböök, Colin Reilly
Dravet syndrome (DS) is a Developmental and Epileptic Encephalopathy (DEE) with onset typically in infancy. Seizures are pharmaco-resistant, and neurodevelopment is compromised in almost all children. There is limited data on the impact of the condition on the family, support needs and hopes and fears in Sweden. Interviews were undertaken with the caregivers of 36 of 48 (75%) living children with DS
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Individual and neighborhood-level socioeconomic deprivation and risk of epilepsy after traumatic brain Injury: A register-based cohort study Epilepsy Behav. (IF 2.6) Pub Date : 2024-04-27 Kasper Lolk, Julie Werenberg Dreier, Jakob Christensen
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Psychiatric complications following SEEG-guided radiofrequency thermocoagulations in patients with drug-resistant epilepsy Epilepsy Behav. (IF 2.6) Pub Date : 2024-04-26 Marianna Bregianni, Francesca Pizzo, Stanislas Lagarde, Julia Makhalova, Agnes Trebuchon, Romain Carron, Lisa Soncin, Marie Arthuis, Fabrice Bartolomei
SEEG-guided radiofrequency thermocoagulation (RF-TC) in the epileptogenic regions is a therapeutic option for patients with drug-resistant focal epilepsy who may have or not indication for epilepsy surgery. The most common adverse events of RF-TC are seizures, headaches, somatic pain, and sensory-motor deficits. If RF-TC could lead to psychiatric complications is unknown. In the present study, seven
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Placebo response in patients with Dravet syndrome: Post-hoc analysis of two clinical trials Epilepsy Behav. (IF 2.6) Pub Date : 2024-04-26 Orrin Devinsky, Kerry Hyland, Rachael Loftus, Charlotte Nortvedt, Rima Nabbout
Dravet syndrome is a rare, early childhood-onset epileptic and developmental encephalopathy. Responses to placebo in clinical trials for epilepsy therapies range widely, but factors influencing placebo response remain poorly understood. This study explored placebo response and its effects on safety, efficacy, and quality of life outcomes in patients with Dravet syndrome. We performed exploratory post-hoc
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Quality of life in people with epilepsy: Associations with resilience, internalized stigma, and clinical factors in a low-income population Epilepsy Behav. (IF 2.6) Pub Date : 2024-04-25 Florence Pélissié Du Rausas, Ignacio Lagger, Pierre-Marie Preux, Khadija Serghini Rousseau, Oscar A. Martínez
Epilepsy is a common neurological disorder associated with comorbidities and a reduced quality of life (QoL). Internalized stigma is negatively correlatedwiththe QoL, whereas high levels of resilience are associated with increased QoL. Although the stigma towards people with epilepsy (PWE) is expected to be higher in low-income settings than in high-income settings, further research is needed. This
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Construction and validation of an algorithm to separate focal and generalised epilepsy using clinical variables: A comparison of machine learning approaches Epilepsy Behav. (IF 2.6) Pub Date : 2024-04-25 Victor Patterson, David H. Glass, Shambhu Kumar, Sarah Misbah El-Sadig, Inaam Mohamed, Rahba El-Amin, Mamta Singh
Epilepsy type, whether focal or generalised, is important in deciding anti-seizure medication (ASM). In resource-limited settings, investigations are usually not available, so a clinical separation is required. We used a naïve Bayes approach to devise an algorithm to do this, and compared its accuracy with algorithms devised by five other machine learning methods. We used data on 28 clinical variables
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Second antiseizure medication monotherapy in patients with adult-onset epilepsy: A register-based analysis Epilepsy Behav. (IF 2.6) Pub Date : 2024-04-25 Konstantinos Polychronidis, Samuel Håkansson, Saman Hosseini Ashtiani, André Idegård, David Larsson, Johan Zelano
Revision of therapy is fundamental in epilepsy care, since only half of patients achieve seizure freedom and tolerate the first antiseizure medication (ASM). We studied the selection and retention of second antiseizure medication monotherapy in adults who discontinued treatment with one of the three most frequently prescribed first ASMs, and the impact of age or brain comorbidities. Using Swedish national
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Prevalence and genotypic associations of epilepsy in Prader-Willi Syndrome: A systematic review and meta-analysis Epilepsy Behav. (IF 2.6) Pub Date : 2024-04-24 Carlos Pascual-Morena, Vicente Martínez-Vizcaíno, Iván Cavero-Redondo, Celia Álvarez-Bueno, Irene Martínez-García, Eva Rodríguez-Gutiérrez, Iris Otero-Luis, Andrea del Saz-Lara, Alicia Saz-Lara
To estimate the prevalence of epilepsy and febrile seizures and their association with genotype, i.e., 15q11-q13 deletions, uniparental chromosome 15 disomy (UPD) and other mutations, in the population with Prader-Willi syndrome (PWS). A systematic search of Medline, Scopus, Web of Science and the Cochrane Library was conducted. Studies estimating the prevalence of seizures, epilepsy and febrile seizures
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Comparison of minimally invasive to standard temporal lobectomy approaches to epilepsy surgery: Seizure relief and visual confrontation naming outcomes Epilepsy Behav. (IF 2.6) Pub Date : 2024-04-24 Karine Hageboutros, Kelsey C. Hewitt, Gregory P. Lee, Aastha Bansal, Cady Block, Nigel P. Pedersen, Jon T. Willie, David W. Loring, Mike R. Schoenberg, Kris A. Smith, Cole A. Giller, Robert E. Gross, Daniel L. Drane
The purpose of this study was to systematically examine three different surgical approaches in treating left medial temporal lobe epilepsy (mTLE) (viz., subtemporal selective amygdalohippocampectomy [subSAH], stereotactic laser amygdalohippocampotomy [SLAH], and anterior temporal lobectomy [ATL]), to determine which procedures are most favorable in terms of visual confrontation naming and seizure relief
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Evaluation of anti-seizure medications and their serum concentration with regard to cardiovascular risk parameters: A cross-sectional study Epilepsy Behav. (IF 2.6) Pub Date : 2024-04-23 Merve Becit-Kizilkaya, Seyma Oncu, Halit Bugra Koca, Dilek Cavusoglu
Epilepsy is a chronic disease that requires long-term monitoring and treatment. It is suspected that there is a interaction between the use of anti-seizure medications and the risk of cardiovascular disease. The aim of the study is to investigate the association between the intake of phenobarbital, carbamazepine and valproic acid and their serum drug concentrations (SDC) with various cardiovascular
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Effect of prednisolone in a kindling model of epileptic seizures in rats on cytokine and intestinal microbiota diversity Epilepsy Behav. (IF 2.6) Pub Date : 2024-04-23 Amanda Muliterno Domingues Lourenço de Lima, Gabriel de Lima Rosa, Edson Fernando Müller Guzzo, Rafael Bremm Padilha, Milena Conci de Araujo, Rodrigo Costa da Silva, Adriana Simon Coitinho, Sueli Teresinha Van Der Sand
Epilepsy is a neurological disease characterized by spontaneous and recurrent seizures. Epileptic seizures can be initiated and facilitated by inflammatory mechanisms. As the dysregulation of the immune system would be involved in epileptogenesis, it is suggested that anti-inflammatory medications could impact epileptic seizures. These medications could potentially have a side effect by altering the
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Cost-effectiveness analysis of HLA-B*15:02 screening before treatment of epilepsy in Indonesia Epilepsy Behav. (IF 2.6) Pub Date : 2024-04-23 Eric Tanoto, Herlyani Khosama, Seilly Jehosua, Sekplin A.S. Sekeon, Winifred Karema, Arthur H.P. Mawuntu, Fima F.L.G. Langi, Lim Kheng Seang
Adverse skin reactions due to drugs such as Stevens Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) occur in 3% of people receiving anti epileptic drugs (AED). Although SJS/TEN has a low incidence, the mortality and morbidity rates are high. Indonesia has not adopted HLA-B*1502 screening prior to administration of carbamazepine (CBZ), although previous studies found a relationship between
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Interictal interleukin-6 and tumor necrosis factor α levels are associated with seizure recurrence in adults with epilepsy Epilepsy Behav. (IF 2.6) Pub Date : 2024-04-23 Wenqiang Fang, Shihao Chen, Xuefen Xia, Wenting Huang, Yanru Du, Zhipeng Liu, Lekai Chen, Xinshi Wang, Huiqin Xu
Although there are models predicting epilepsy recurrence under different clinical conditions, few studies have examined blood biomarkers. Inflammation plays a crucial role in the occurrence and development of epilepsy. We analyzed inflammatory mediators in a regional hospital-based epilepsy cohort and investigated their relationship with subsequent epilepsy recurrence. Interictal inflammatory mediators
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Current challenges in focal epilepsy treatment: An Italian Delphi consensus Epilepsy Behav. (IF 2.6) Pub Date : 2024-04-20 Giancarlo Di Gennaro, Simona Lattanzi, Oriano Mecarelli, Francesco Saverio Mennini, Federico Vigevano
Epilepsy, a globally prevalent neurological condition, presents distinct challenges in management, particularly for focal-onset types. This study aimed at addressing the current challenges and perspectives in focal epilepsy management, with focus on the Italian reality. Using the Delphi methodology, this research collected and analyzed the level of consensus of a panel of Italian epilepsy experts on
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Identifying co-morbidities and risk in people with epilepsy: The Maltese experience Epilepsy Behav. (IF 2.6) Pub Date : 2024-04-20 Adrian Pace, Lance Watkins, Daniel Fiott, Paul Bassett, Richard Laugharne, Christopher James, Rohit Shankar
People with epilepsy are at increased risk of multiple co-morbidities that may influence risk of adverse outcomes including impact on quality of life and premature mortality. These risk factors include potentially modifiable clinical characteristics associated with sudden unexpected death in epilepsy (SUDEP). For services to tackle risk, the clinical complexity of the target epilepsy population needs
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Changes in pediatric referrals after the 2009 ketogenic diet consensus recommendations Epilepsy Behav. (IF 2.6) Pub Date : 2024-04-20 Rebecca S. Stainman, Zahava Turner, Eric H. Kossoff
In 2009, the International Ketogenic Diet Study Group published recommendations for children receiving ketogenic diet (KD) therapy for epilepsy. The document included a table listing epilepsy syndromes and conditions in which the KD has been particularly beneficial, hoping that physicians would refer children for the KD sooner. To measure the impact of these 2009 recommendations on referral practice
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Assessment of knowledge towards first aid skills of epilepsy among undergraduate health students in Riyadh province of Saudi Arabia: A cross-sectional study Epilepsy Behav. (IF 2.6) Pub Date : 2024-04-20 Abdulrahman M. Alshahrani, Naif Khalid Alsayed, Nemer Alotaibi, Mohammad Azhar Rashikh, Abdulrahman Talal Alghebaiwi, Faisal Faihan Alotaibi, Abdulaziz Faisal Alotaibi, Abdullah Mohammed bin Hussain, Nawaf Mansour N Alotaibi, Mazen Saud Alotaibi
Applying proper first-aid measures to patients with seizure episodes plays a vital role in preventing the adverse consequences of seizures. Most previous data focused on teachers, healthcare providers and the general public. This study aimed to assess the knowledge of seizure first-aid measures among undergraduate health students. This descriptive, cross-sectional study was conducted between May 16
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Dravet syndrome seizure frequency and clustering: Placebo-treated patients in clinical trials Epilepsy Behav. (IF 2.6) Pub Date : 2024-04-20 Rima Nabbout, Kerry Hyland, Rachael Loftus, Charlotte Nortvedt, Orrin Devinsky
Dravet syndrome is a rare developmental epilepsy syndrome associated with severe, treatment-resistant seizures. Since seizures and seizure clusters are linked to morbidity, reduced quality of life, and premature mortality, a greater understanding of these outcomes could improve trial designs. This analysis explored seizure types, seizure clusters, and factors affecting seizure cluster variability in
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Differential relational memory impairment in temporal lobe epilepsy Epilepsy Behav. (IF 2.6) Pub Date : 2024-04-20 Shahin Tavakol, Valeria Kebets, Jessica Royer, Qiongling Li, Hans Auer, Jordan DeKraker, Elizabeth Jefferies, Neda Bernasconi, Andrea Bernasconi, Christoph Helmstaedter, Thaera Arafat, Jorge Armony, R. Nathan Spreng, Lorenzo Caciagli, Birgit Frauscher, Jonathan Smallwood, Boris Bernhardt
Temporal lobe epilepsy (TLE) is typically associated with pathology of the hippocampus, a key structure involved in relational memory, including episodic, semantic, and spatial memory processes. While it is widely accepted that TLE-associated hippocampal alterations underlie memory deficits, it remains unclear whether impairments relate to a specific cognitive domain or multiple ones. We administered
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Sleep profiles in epilepsy patients undergoing monotherapy and polytherapy: A comparative cross-sectional study Epilepsy Behav. (IF 2.6) Pub Date : 2024-04-19 Alireza Arvin, Morvarid Taebi, Zahra Khazaeipour, Arezu Najafi, Abbas Tafakhori, Sakineh Ranji-Bourachaloo, Hamed Amirifard
Sleep disturbances commonly reported among epilepsy patients have a reciprocal relationship with the condition; While epilepsy and anti-seizure medications (ASMs) can disrupt sleep structure, disturbed sleep can also exacerbate the frequency of seizures. This study explored subjective sleep disturbances and compared sleep profiles in patients who underwent ASM monotherapy and polytherapy. We enrolled
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The association of perceived stigma, religiosity, and paranormal beliefs in parents of children with epilepsy Epilepsy Behav. (IF 2.6) Pub Date : 2024-04-19 Müjde Kerkez, Özlem Vural
The aim of this study is to investigate the relationship between stigma perception, religiosity, and paranormal beliefs in parents of children with epilepsy. The sample of this cross-sectional study consisted of 103 parents of children with epilepsy registered at a state hospital in a city with middle socio-economic status located in southeastern Türkiye. The data were collected using descriptive information
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Clinical characteristics of patients with refractory non-epileptic seizures Epilepsy Behav. (IF 2.6) Pub Date : 2024-04-19 Sarah Fullam, Daniel J. Costello
This incidence of non-epileptic seizures (NES) is estimated at 1–35 per 100,000 population. While many patients achieve remission, a significant fraction of patients have a poor prognosis despite optimal interventions. This study reports on the characteristics of patients with refractory NES diagnosed and treated at a comprehensive epilepsy centre. A retrospective review of admissions to the Epilepsy
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Characterization and quantification of epilepsy patients with hospital episodes in Portugal: A multicenter retrospective study from Liga Portuguesa Contra a Epilepsia Epilepsy Behav. (IF 2.6) Pub Date : 2024-04-19 Carla Bentes, Nuno Canas, Hugo Pedrosa, João Completo, Fábio Pereira, Magda Carrilho, José Lopes Lima, Cristina Pereira, Ricardo Rego, Helena Rocha, Francisca Sá, Francisco Sales, Manuela Santos, Rute Teotónio
Epilepsy affects around 50 million people worldwide and is associated with lower quality of life scores, an increased risk of premature death, and significant socio-economic implications. The lack of updated evidence on current epidemiology and patient characterization creates considerable uncertainty regarding the epilepsy burden in Portugal. The study aims to characterize and quantify the epilepsy
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Being an adolescent with epilepsy during the transition from pediatric to adult hospital care: A qualitative descriptive study Epilepsy Behav. (IF 2.6) Pub Date : 2024-04-18 Ole Abildgaard Hansen, Jane Clemensen, Christoph P. Beier, Gry Pors Klinting, Anthony C. Smith, Malene Kaas Larsen
The transition from pediatric to adult care is challenging for adolescent patients despite numerous recommendations in recent decades. However, the perspective of the patients is sparsely investigated. To explore the experiences and needs of adolescents with epilepsy (AWE) during the transition from pediatric to adult hospital care. We conducted 15 semi-structured interviews with AWEs aged 13–20 years
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Do we intervene less and slower in the epilepsy monitoring unit for psychogenic seizures? Epilepsy Behav. (IF 2.6) Pub Date : 2024-04-18 Jimmy Li, Amal Hagouch, Julie Forand, Dang Khoa Nguyen
Individuals with psychogenic non-epileptic seizures (PNES) can be stigmatized in healthcare settings. We aimed to compare intervention rate (IR), intervention time (IT), and adverse event (AE) rate between PNES and epileptic seizures (ES) in the epilepsy monitoring unit (EMU). We used a prospective database of consecutive admissions to our centre’s EMU between August 2021 and September 2022. We excluded
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Bilateral glymphatic dysfunction and its association with disease duration in unilateral temporal lobe epilepsy patients with hippocampal sclerosis Epilepsy Behav. (IF 2.6) Pub Date : 2024-04-18 Fangfang Xie, Chunyao Zhou, Hong Jin, Wu Xing, Dongcui Wang
In this study, the diffusion tensor imaging along perivascular space analysis (DTI-ALPS) technique was utilized to evaluate the functional changes in the glymphatic system of the bilateral hemispheres in patients with unilateral temporal lobe epilepsy (TLE) accompanied by hippocampal sclerosis (HS). The aim was to gain insights into the alterations in the glymphatic system function in TLE patients
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Social support and the burden of physical and psychiatric comorbidities in the patients with late-onset epilepsy in China: A cross-sectional study Epilepsy Behav. (IF 2.6) Pub Date : 2024-04-18 Shengyi Liu, Zhen Cao, Zihua He, Wenyan Shi, Jinmei Li
Epilepsy is the third most common neurological disorder in elderly people. Patients with epilepsy (PWEs) are more likely to have comorbidities. Social support is very important for PWEs. However, there are many gaps in the research on social support in older PWEs, especially the correlation between social support and comorbidities. A cross-sectional study was conducted in three hospitals in China.
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Predictors of genetic diagnosis in individuals with developmental and epileptic encephalopathies Epilepsy Behav. (IF 2.6) Pub Date : 2024-04-18 Maria Luiza Benevides, Helena T. de Moraes, Diana M.M. Granados, Luciana C. Bonadia, Letícia Sauma, Maria Augusta Montenegro, Marilisa M. Guerreiro, Íscia Lopes-Cendes, Ana Carolina Coan
To evaluate the clinical predictors of positive genetic investigation in developmental and epileptic encephalopathies, beyond the influence of Dravet Syndrome. The study included 98 patients diagnosed with developmental and epileptic encephalopathies. The patients underwent Sanger sequencing of , Chromosomal Microarray Analysis, and Whole Exome Sequencing. The association of clinical variables with
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Association of early seizures after ischemic stroke with diffusion-weighted imaging-alberta stroke program early CT score (DWI-ASPECTS) and neutrophil-to-lymphocyte ratio Epilepsy Behav. (IF 2.6) Pub Date : 2024-04-18 Maryam Ebrahimian, Mohamad Hosein Mohamadi, Mahshid Mahyad, Fariborz Rezaeitalab
Post-stroke seizure (PSS) is a common considerable complication of acute ischemic stroke (AIS). Early risk assessment can clinical practitioners to plan effective prevention and management. We aimed to determine whether assessing Diffusion-Weighted Imaging-Alberta Stroke Program Early CT Score (DWI-ASPECTS), and neutrophil indices allows for identifying patients at risk of PSS. This prospective study
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Evaluating the prevalence and risk factors for depression in patients with temporal lobe epilepsy with hippocampal sclerosis: A cross-sectional multicenter study Epilepsy Behav. (IF 2.6) Pub Date : 2024-04-18 Bandar N. Aljafen, Ruwa Alneseyan, Taim Muayqil, Mashael O. Alkhateeb, Mubarak M. Aldosari, Aya Alsermani, Lujain Alnakhli, Renad Althomali, Razan Alnami, Ruba Alqahtani, Lama Ibrahim, Fawzi Babtain
Epilepsy frequently accompanies Major Depressive Disorder (MDD). Notably, people with temporal lobe epilepsy and hippocampal sclerosis may face an increased susceptibility to MDD, as evidence indicates the involvement of the limbic system in the development of emotional symptoms. To determine the prevalence and predictors of depression in temporal lobe epilepsy with hippocampal sclerosis (TLE-HS) and
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“This is real”, “this is hard” and “I’m not making it up”: Experience of diagnosis and living with non-epileptic attack disorder Epilepsy Behav. (IF 2.6) Pub Date : 2024-04-18 Geralynn Walsh, Charlotte Emma Wilson, David Hevey, Susan Moore, Cora Flynn, Erin Breheny, Fiadhnait O'Keeffe
To use a qualitative research approach to explore adults’ experience of living with non-epileptic attack disorder. The objective was to explore the experience of adults (18 years+) with a confirmed diagnosis of non-epileptic attack disorder (NEAD) across the trajectory of the disorder. The topics investigated included the onset of symptoms, the experience of non-epileptic attacks, the diagnostic process
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Relationships among anxiety, depression, and health-related quality of life in adult epilepsy: A network analysis Epilepsy Behav. (IF 2.6) Pub Date : 2024-04-18 Hui Song, Yuping Zhao, Chunmei Hu, Chenxiao Zhao, Xuefeng Wang, Zheng Xiao
Comorbid depression and anxiety in patients with epilepsy (PWE) are common and frequently under-treated, thus, causing poor health-related quality of life (HRQoL). However, little is known regarding the interconnections between anxious/depressive symptoms and the dimensions of HRQoL. Therefore, we conducted a network analysis to explore these relationships in detail among Chinese adult PWE. A cohort
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Novelty preference assessed by eye tracking: A sensitive measure of impaired recognition memory in epilepsy Epilepsy Behav. (IF 2.6) Pub Date : 2024-04-17 Beth A. Leeman-Markowski, Samantha P. Martin, Richard Hardstone, Danny M. Tam, Orrin Devinsky, Kimford J. Meador
Epilepsy patients often report memory deficits despite normal objective testing, suggesting that available measures are insensitive or that non-mnemonic factors are involved. The Visual Paired Comparison Task (VPCT) assesses novelty preference, the tendency to fixate on novel images rather than previously viewed items, requiring recognition memory for the “old” images. As novelty preference is a sensitive
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The effect of 20-minute mindful breathing exercise on psychological well-being in epilepsy: A pilot randomized controlled trial Epilepsy Behav. (IF 2.6) Pub Date : 2024-04-17 Kheng-Seang Lim, Si-Lei Fong, Xuen Yu, Ying-Huan Lim, Kian-Yong Wong, Siew-Tim Lai, Chong-Guan Ng, Chong-Tin Tan, Seng-Beng Tan
Depression and anxiety are prevalent in epilepsy patients, but psychiatric or psychological services may not be accessible to all patients. This study aimed to determine the effectiveness of the 20-minute mindful breathing on the psychological well-being of PWE using an instructional video. This was a pilot, assessor-blinded, randomized controlled trial. The intervention group received a guided video
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Medication adherence and its relationship with self-esteem among patients with epilepsy in Isfahan, Iran Epilepsy Behav. (IF 2.6) Pub Date : 2024-04-17 Moien Motioleslam, Malek Fereidooni-Moghadam, Masood Etemadifar, Zeinab Mohebi
Medication adherence is of utmost importance in achieving the desired therapeutic outcome and effectively managing seizures in patients with epilepsy (PWE). It is imperative to recognize self-esteem as a psychological determinant that potentially influences the optimal compliance with anti-seizure medications (ASMs) among PWE. The objective of this study was to explore medication adherence and its
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Mortality and mortality disparities among people with epilepsy in the United States, 2011–2021 Epilepsy Behav. (IF 2.6) Pub Date : 2024-04-17 Niu Tian, Rosemarie Kobau, Daniel Friedman, Yong Liu, Paul I. Eke, Kurt J. Greenlund
Studies on epilepsy mortality in the United States are limited. We used the National Vital Statistics System Multiple Cause of Death data to investigate mortality rates and trends during 2011–2021 for epilepsy (defined by the codes G40.0–G40.9) as an underlying, contributing, or any cause of death (i.e., either an underlying or contributing cause) for U.S. residents. We also examined epilepsy as an
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Death of a loved one: A potential risk factor for onset of functional seizures Epilepsy Behav. (IF 2.6) Pub Date : 2024-04-17 Meagan Watson, Kimberlyn Cook, Stefan Sillau, Elizabeth Greenwell, Randi Libbon, Laura Strom
Functional seizures (FS) are a symptom of Functional Neurological Disorder (FND), the second most common neurological diagnosis made worldwide. Childhood trauma is associated with the development of FS, but more research is needed to truly understand the effects of trauma on FS onset. A sample of 256 responses by adults with FS to the Childhood Traumatic Events Scale were analyzed using a Cox proportional
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The prevalence and correlates of PTSD, insomnia, and fatigue among people with epilepsy during Oct.7th war on Gaza: A study from Jordan Epilepsy Behav. (IF 2.6) Pub Date : 2024-04-17 Omar Gammoh, Wail Ennab
Jordan and Palestine are tightly related countries as the same families live in the two adjacent countries. The present study sought to examine the prevalence and determinants of Post-Traumatic Stress Disorder (PTSD)symptoms, insomnia, and fatigue among a cohort of People with Epilepsy (PWE) in Jordan. This is a cross-sectional study with inclusion criteria. PTSD, insomnia, and fatigue were assessed
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Artificial intelligence/machine learning for epilepsy and seizure diagnosis Epilepsy Behav. (IF 2.6) Pub Date : 2024-04-17 Kenneth Han, Chris Liu, Daniel Friedman
Accurate seizure and epilepsy diagnosis remains a challenging task due to the complexity and variability of manifestations, which can lead to delayed or missed diagnosis. Machine learning (ML) and artificial intelligence (AI) is a rapidly developing field, with growing interest in integrating and applying these tools to aid clinicians facing diagnostic uncertainties. ML algorithms, particularly deep
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Attention-based deep convolutional neural network for classification of generalized and focal epileptic seizures Epilepsy Behav. (IF 2.6) Pub Date : 2024-04-17 Taimur Shahzad Gill, Syed Sajjad Haider Zaidi, Muhammad Ayaz Shirazi
Epilepsy affects over 50 million people globally. Electroencephalography is critical for epilepsy diagnosis, but manual seizure classification is time-consuming and requires extensive expertise. This paper presents an automated multi-class seizure classification model using EEG signals from the Temple University Hospital Seizure Corpus ver. 1.5.2. 11 features including time-based correlation, time-based
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Comparative analysis of adverse drug reactions associated with new antiseizure medications from the Korea Adverse Event Reporting System database Epilepsy Behav. (IF 2.6) Pub Date : 2024-04-17 Hyun Kyung Kim, Kyung Sik Jang, Dong Wook Kim
This study aimed to compare and characterize the safety profiles of new antiseizure medications (ASMs) using a nationwide pharmacovigilance database from a long-term perspective in Korea. We reviewed adverse event reports from the Korea Adverse Event Reporting System database between January 2013 and December 2022 for descriptive analysis of six new ASMs (lacosamide, levetiracetam, lamotrigine, oxcarbazepine
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A systematic review of the Mozart effect in adult and paediatric cases of drug-resistant epilepsy: A sound approach to epilepsy management Epilepsy Behav. (IF 2.6) Pub Date : 2024-04-17 Lucrezia Maria Piccicacchi, Domenico Serino
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Postictal psychiatric symptoms: A neurophysiological study Epilepsy Behav. (IF 2.6) Pub Date : 2024-04-08 Daniel S. Weisholtz, Alexa Roy, Ava Sanayei, Brannon Cha, Dustine Reich, David A. Silbersweig, Barbara A. Dworetzky
Postictal psychiatric symptoms (PPS) are a relatively common but understudied phenomenon in epilepsy. The mechanisms by which seizures contribute to worsening in psychiatric symptoms are unclear. We aimed to identify PPS prospectively during and after admission to the epilepsy monitoring unit (EMU) in order to characterize the postictal physiologic changes leading to PPS. We prospectively enrolled
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Impact of the COVID-19 pandemic, its related social restriction measures and vaccination campaign on emergency department attendances for epileptic seizures: An interrupted time-series analysis Epilepsy Behav. (IF 2.6) Pub Date : 2024-03-30 Francesco Brigo, Gloria Brigiari, Michael Mian, Gianni Turcato, Serena Sibilio, Arian Zaboli
To investigate the impact of the outbreak of the COVID-19 pandemic, its related social restriction measure (national lockdown) and vaccination campaign on emergency department (ED) accesses for epileptic seizures. Retrospective observational analysis conducted on a consecutive cohort of patients who sought medical care at the ED of the General Hospital of Merano, Italy, from January 1, 2015, to December
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A quantitative cross-sectional study of the burden of caring for patients with Lennox-Gastaut syndrome, Dravet syndrome, and tuberous sclerosis complex-associated epilepsy in Japan Epilepsy Behav. (IF 2.6) Pub Date : 2024-03-30 Michael LoPresti, Ataru Igarashi, Yaoki Sonohara, Sally Bowditch
Lennox-Gastaut syndrome (LGS), Dravet syndrome (DS), and tuberous sclerosis complex (TSC)-associated epilepsy are rare conditions associated with severe childhood-onset epilepsy. Caregivers play a critical role in the patients’ care and may experience significant psychosocial and socioeconomic burden. This cross-sectional study determined the burden of caring for patients with these rare epilepsy conditions
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Long-term characterization of cognitive phenotypes in children with seizures over 36 months Epilepsy Behav. (IF 2.6) Pub Date : 2024-03-29 Jordan Eisner, Danielle Harvey, David Dunn, Jana Jones, Anna Byars, Philip Fastenau, Joan Austin, Bruce Hermann, Temitayo Oyegbile-Chidi
Children with new-onset epilepsies often exhibit co-morbidities including cognitive dysfunction, which adversely affects academic performance. Application of unsupervised machine learning techniques has demonstrated the presence of discrete cognitive phenotypes at or near the time of diagnosis, but there is limited knowledge of their longitudinal trajectories. Here we investigate longitudinally the
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The effects of web-based animation-supported progressive relaxation exercises applied to individuals with epilepsy on fatigue and sleep quality: A randomized controlled study Epilepsy Behav. (IF 2.6) Pub Date : 2024-03-29 Neşe İşcan Ayyildiz, Nuray Bingöl
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The relationship between medication adherence and complementary medicine use in epilepsy patients Epilepsy Behav. (IF 2.6) Pub Date : 2024-03-28 Fatma Gündüz Oruç, Gülden Atan, Demet Şeker
The aim of this research is to examine the usage of Complementary and Integrated Medicine (CIM) in individuals with epilepsy and the impact of CIM usage on medication adherence. This descriptive and cross-sectional study was conducted in a university hospital in northern Turkey between July and October 2023, involving 101 individuals with epilepsy (PWE). Descriptive information forms and the Morisky
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Association between serum apolipoprotein E and cognitive function in Chinese patients with temporal lobe epilepsy Epilepsy Behav. (IF 2.6) Pub Date : 2024-03-28 Yuwei Han, Guangzhi Hao, Zhen Wang, Chenchen Wang, Xin Qi, Guobiao Liang, Xiaoming Li
To investigate the effect of serum apolipoprotein E (APOE) levels on cognitive function in patients with temporal lobe epilepsy (TLE). Clinical data were collected from 190 subjects including 110 TLE patients and 80 healthy people. Cognitive function was assessed using the Addenbrooke’s Cognitive Examination Revised (ACE-R) scale. Serum levels of APOE were measured using ELISA kits. Genotyping of APOE
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Psychiatric and behavioral concerns of perampanel with concomitant levetiracetam in children with epilepsy Epilepsy Behav. (IF 2.6) Pub Date : 2024-03-27 Jon Soo Kim, Won Seop Kim, Won Young Sung, Hyewon Woo
Perampanel (PER) is expanding the therapeutic scope for pediatric epilepsy owing to its efficacy and favorable safety profile. However, concerns about psychiatric and behavioral adverse events (PBAEs) in combination therapy with levetiracetam (LEV) continue to contribute to hesitation in its prescription. We investigated the risk profiles for PBAEs when adding PER to pediatric epilepsy treatment and
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Deep learning approaches for seizure video analysis: A review Epilepsy Behav. (IF 2.6) Pub Date : 2024-03-23 David Ahmedt-Aristizabal, Mohammad Ali Armin, Zeeshan Hayder, Norberto Garcia-Cairasco, Lars Petersson, Clinton Fookes, Simon Denman, Aileen McGonigal
Seizure events can manifest as transient disruptions in the control of movements which may be organized in distinct behavioral sequences, accompanied or not by other observable features such as altered facial expressions. The analysis of these clinical signs, referred to as semiology, is subject to observer variations when specialists evaluate video-recorded events in the clinical setting. To enhance
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Breathing control training for functional seizures: A multi-site, open-label pilot study Epilepsy Behav. (IF 2.6) Pub Date : 2024-03-22 Roderick Duncan, David J Berlowitz, Saul Mullen, Janet Bondarenko, Toby T Winton-Brown, Terence J O'Brien, Sophie Zaloumis, Sabine Braat, Georgina Oliver, Richard A Kanaan
There are no well-validated treatments for functional seizures. While specialist psychotherapy is usually recommended, the evidence for its benefit is qualified, and it can be difficult to obtain. Given the association between hyperventilation and functional seizures we explored an alternative modality, breathing control training, in a multi-site open label pilot trial. Participants with functional
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PCDH19-clustering epilepsy, pathophysiology and clinical significance Epilepsy Behav. (IF 2.6) Pub Date : 2024-03-22 Safoura Kowkabi, Majid Yavarian, Reza Kaboodkhani, Mahmood Mohammadi, Reza Shervin Badv
PCDH19 clustering epilepsy (PCDH19-CE) is an X-linked epilepsy disorder associated with intellectual disability (ID) and behavioral disturbances, which is caused by PCDH19 gene variants. PCDH19 pathogenic variant leads to epilepsy in heterozygous females, not in hemizygous males and the inheritance pattern is unusual. The hypothesis of cellular interference was described as a key pathogenic mechanism
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The promise of AI Large Language Models for Epilepsy care Epilepsy Behav. (IF 2.6) Pub Date : 2024-03-21 Raphaëlle Landais, Mustafa Sultan, Rhys H Thomas
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Estimating the active and lifetime prevalence and incidence of epilepsy in Asian Countries: A systematic review and meta-analysis Epilepsy Behav. (IF 2.6) Pub Date : 2024-03-21 Mohammed Safeer V S, Jitendra Kumar Sahu, Priyanka Madaan, Sebastian F. Winter, Gus A. Baker, Dipika Bansal
In the current era of the World Health Organization's Intersectoral Global Action Plan on Epilepsy and Other Neurological Disorders 2022–2031 (IGAP), precise and updated estimates of epilepsy burden are vital in formulating policies to improve the care of persons with epilepsy, especially in Asian countries with significant treatment gap. Hence, we aimed to consolidate the available data and quantify
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Utilization of APE2 and RITE2 scores in autoimmune encephalitis patients with seizures Epilepsy Behav. (IF 2.6) Pub Date : 2024-03-21 Trevor Rafferty, Anna Koeppen-Babcock, Srikanth Muppidi, Yi Li, Scheherazade Le
Immune-mediated seizures are rare but are increasingly recognized as an etiology of seizures resistant to anti-seizure medications (ASMs). Antibody Prevalence in Epilepsy 2 (APE2) and Response to Immunotherapy in Epilepsy 2 (RITE2) scores were developed recently to identify patients who may be seropositive for serum central nervous system (CNS) specific antibodies (Ab) and may benefit from immunotherapy
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What we have learned from non-human primates as animal models of epilepsy Epilepsy Behav. (IF 2.6) Pub Date : 2024-03-21 Viviam Sanabria, Simone A.A. Romariz, Matheus Braga, Jaime Moreira Pires, Maria da Graça Naffah-Mazzacoratti, Luiz Eugênio Mello, Beatriz M. Longo, Maira Licia Foresti
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Resilience and psychosocial factors in adult with epilepsy: A longitudinal study Epilepsy Behav. (IF 2.6) Pub Date : 2024-03-20 M. Tombini, F. Narducci, L. Ricci, B. Sancetta, M. Boscarino, L. Quintiliani, J. Lanzone, M. Straffi, V. Di Lazzaro, G. Assenza
Resilience is conceptually characterized as a dynamic process encompassing positive adaptation in the context of significant adversity. Our goal was to assess the resilience in people with epilepsy (PWE) and how it impacts longitudinally on psychosocial factors, with a particular focus on the manifestation of stigmatization-related feelings. We consecutively enrolled 78 adults PWE (42.5 ± 16.2 years
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eDeeplepsy: An artificial neural framework to reveal different brain states in children with epileptic spasms Epilepsy Behav. (IF 2.6) Pub Date : 2024-03-20 Alberto Nogales, Álvaro J. García-Tejedor, Juan Serrano Vara, Arturo Ugalde-Canitrot
Despite advances, analysis and interpretation of EEG still essentially rely on visual inspection by a super-specialized physician. Considering the vast amount of data that composes the EEG, much of the detail inevitably escapes ordinary human scrutiny. Significant information may not be evident and is missed, and misinterpretation remains a serious problem. Can we develop an artificial intelligence