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Proinflammatory microglial response is a common mechanism of Aroclor 1254- and Tetrabromobisphenol-A-induced neurotoxicity in immature chronically exposed rats Folia Neuropathol. (IF 2.0) Pub Date : 2024-03-29 Beata Dąbrowska-Bouta, Grzegorz Sulkowski, Małgorzata Frontczak-Baniewicz, Dorota Sulejczak, Lidia Strużyńska
Polychlorinated biphenyls (PCBs) and brominated flame retardants (BFRs) are dominant environmental and food contaminants. Tetrabromobisphenol A (TBBPA) is the most widely used BFR in the world to improve the fire safety of laminates in electrical and electronic equipment. Aroclor 1254, one of the PCBs, is widely distributed in the environment due to its extensive use in industrial applications around
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Safety of GMP-compliant iPSC lines generated by Sendai virus transduction is dependent upon clone identity and sex of the donor Folia Neuropathol. (IF 2.0) Pub Date : 2024-03-29 Zuzanna Kuczynska, Pawan Kumar Neglur, Erkan Metin, Michal Liput, Marzena Zychowicz, Valery Zayat, Natalia E. Krześniak, Leonora Buzanska, Marta Kot
Human induced pluripotent stem cells (hiPSCs) are a potential source of somatic cells for cell therapies due to their ability to self-renew and differentiate into various cells of the body. To date, the clinical application of hiPSCs has been limited due to safety issues. The present study aims to standardize the safety procedure of the derivation of GMP-compliant induced pluripotent stem cell (iPSC)
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The diagnostic challenge of lack of choline level elevation on 1H-MR spectroscopy in grade II-III gliomas Folia Neuropathol. (IF 2.0) Pub Date : 2024-03-25 Barbara Bobek-Billewicz, Sylwia Heinze, Krzysztof Majchrzak, Patrycja Mazgaj, Anna Hebda
The accurate diagnosis of brain tumour is very important in modern neuro-oncology medicine. Magnetic resonance spectroscopy (MRS) is supposed to be a promising tool for detecting cancerous lesions. However, the interpretation of MRS data is complicated by the fact that not all cancerous lesions exhibit elevated choline (Cho) levels. The main goal of our study was to investigate the lack of Cholesion/Choref
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Transformation of IDH-wildtype glioblastoma to gliosarcoma with features of osteosarcoma Folia Neuropathol. (IF 2.0) Pub Date : 2024-03-12 Paweł Sobczyk, Michał Sobstyl, Albert Acewicz, Joanna Rosa, Marta Grabiec, Wiesława Grajkowska
Gliosarcoma (GS) is a rare variant of IDH-wildtype glioblastoma. It is classified as grade 4 in the latest WHO CNS classification of both glial and mesenchymal components. Gliosarcoma may arise de novo or secondary from glioblastoma. It occurs in up to 2% of patients diagnosed with glioblastoma. We present a case report of a 51-year-old patient who was initially diagnosed with glioblastoma multiforme
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A current view of mitochondria damage and the diversity of lipopigment inclusions in neuronal ceroid lipofuscinose type 2 from rectal biopsy Folia Neuropathol. (IF 2.0) Pub Date : 2024-03-01 Paulina Felczak, Aleksandra Kuźniar-Pałka, Agnieszka Ługowska, Elżbieta Stawicka, Sylwia Tarka, Hanna Mierzewska
Neuronal ceroid lipofuscinoses (NCLs) are a growing group of neurodegenerative storage diseases, in which specific features are sought to facilitate the creation of a universal diagnostic algorithm in the future. In our ultrastructural studies, the group of NCLs was represented by the CLN2 disease caused by a defect in the TPP1 gene encoding the enzyme tripeptidyl-peptidase 1. A 3.5-year-old girl was
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Extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue of the dura mimicking meningioma: a case report and literature review Folia Neuropathol. (IF 2.0) Pub Date : 2024-02-16 Piotr Glinka, Michał Sobstyl, Grzegorz Rymkiewicz, Teresa Wierzba-Bobrowicz, Ewa Paszkiewicz-Kozik, Wiesława Grajkowska
MALT lymphoma of the dura is a very rare type of low-grade B-cell lymphoma. Little more than 100 cases have been reported in the literature to date. We report a 43-year-old woman who was referred to hospital because of a series of three tonic-clonic seizures on the day of admission. Neurological examination revealed confusion and aphasia. Magnetic resonance imaging (MRI) showed a contrast-enhanced
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“Neuropatologia Polska”. The journal and its topics in the first decade of existence (1963–1972) Folia Neuropathol. (IF 2.0) Pub Date : 2023-12-29 Piotr Paluchowski, Jacek Gulczyński, Mateusz Michalski, Teresa Wierzba-Bobrowicz, Dorota Sulejczak, Ewa Iżycka-Świeszewska
In this article authors would like to present the history of the “Neuropatologia Polska” journal (since 1994: “Folia Neuropathologica”) in its first decade of existence. It outlines the circumstances surrounding the creation of the journal and shows how it evolved in the first years. The vast material analysed from the consecutive issues of the journal in the years from 1963 to 1972 was subjected to
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The use of MR perfusion parameters in differentiation between glioblastoma recurrence and radiation necrosis Folia Neuropathol. (IF 2.0) Pub Date : 2023-12-29 Barbara Bobek-Billewicz, Sylwia Heinze, Aleksandra Awramienko-Wloczek, Krzysztof Majchrzak, Elzbieta Nowicka, Anna Hebda
Introduction: This study focuses on the challenge of distinguishing between tumour recurrence and radiation necrosis in glioma treatment using magnetic resonance imaging (MRI). Currently, accurate differentiation is possible only through surgical biopsy, which is invasive and may cause additional damage. The study explores non-invasive methods using dynamic susceptibility contrast (DSC) MR perfusion
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Off-label use of eculizumab for neurological symptoms and progressive vision loss Folia Neuropathol. (IF 2.0) Pub Date : 2023-12-29 Alicja Kuźniewska, Marta Jaskólska, Mariusz Kwarciany, Aleksandra Ciarka, Rafał Pęksa, Zbigniew Zdrojewski, Marcin Okrój
We describe the results of eculizumab treatment of a patient with pachymeningitis, inflammatory infiltration of the left frontal lobe, and cerebral hematoma, who presented with progressive vision loss, epileptic seizures, and abnormal pattern of the complement system parameters. A 30-year-old female patient, initially diagnosed with hypereosinophilia and a tumour of the left orbit, developed a significant
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The neutrophil extracellular traps-related gene signature predicts the prognosis of glioblastoma multiforme Folia Neuropathol. (IF 2.0) Pub Date : 2023-12-20 Guanghui Sun, Wei Liu
Introduction: This research hoped to explore the molecular mechanism of neutrophil extracellular traps (NETs) on glioblastoma multiforme (GBM) progression, and develop a promising prognostic signature for GBM based on NETs-related genes (NETGs). Material and methods: Gene expression data and clinical data of GBM tumour samples were downloaded from TCGA and CGGA databases. NETs-related molecular subtypes
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LMTK2 inhibits Ab25-35-elicited ferroptosis, oxidative stress and apoptotic damage in PC12 cells through activating Nrf2/ARE signalling pathway Folia Neuropathol. (IF 2.0) Pub Date : 2023-12-08 Lili Zhang, Fei Shu
Alzheimer’s disease (AD), the most common contributor to dementia, is a growing global health problem. This study aimed to investigate the role of lemur tyrosine kinase 2 (LMTK2) in AD as well as its relevant mechanism. To establish an in vitro cell model, PC12 cells were challenged with 20 µmol/l Ab25-35 for 24 h. RT-qPCR and western blot examined LMTK2 mRNA and protein expressions. With the application
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Targeting the Nrf2-dependent mechanism of b-Ecdysterone in attenuating the motor dysfunction in the MPTP/Pro-induced Parkinson’s disease mice model Folia Neuropathol. (IF 2.0) Pub Date : 2023-11-22 Hua Rong, Xiaoming Li, Chunlei Yu, Wenbao Wang, Libo Li, Tianjiao Xu, Yisong Ding, Yingshi Su, Xiaoli Wang
Oxidative stress is a pivotal stimulating factor in neurocyte apoptosis and has been involved in the pathogenesis of Parkinson’s disease (PD). In this study, we have demonstrated that the improvement in the motor disorder of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)/Pro-induced mice caused by b-Ecdysterone (b-Ecd) treatment is due to its antioxidant properties. Using open field, rotarod,
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Exercise attenuates mitochondrial autophagy and neuronal degeneration in MPTP induced Parkinson’s disease by regulating inflammatory pathway Folia Neuropathol. (IF 2.0) Pub Date : 2023-11-22 Zhiwei Li, Hua Lv, Xiaoli Cui, Wei Di, Xiansong Cheng, Jun Liu, Alok Tripathi
Parkinson’s disease (PD) is a chronic neuronal loss of dopamine and drugs used for its management has several limitations. The present report determines the effect of exercise on mitochondrial autophagy against PD. Parkinson’s disease was induced by 15 doses of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP; 30 mg/kg, i.p.) for 3 weeks, on five consecutive days in a week. Exposure of exercise was
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Attitudes of caregivers towards prolonging and shortening life in advanced stages of amyotrophic lateral sclerosis Folia Neuropathol. (IF 2.0) Pub Date : 2023-11-21 Anna Maksymowicz-Śliwińska, Dorothée Lulé, Krzysztof Nieporęcki, Katarzyna Ciećwierska, Albert C. Ludolph, Magdalena Kuźma-Kozakiewicz
Introduction: Inevitable disease progression in amyotrophic lateral sclerosis (ALS) forces patients and their caregivers (CGs) to reflect on end-of-life treatment. The CGs are often heavily burdened with their role of surrogate decision-makers. The aim of the study was to analyze attitudes of CGs and presumable attitudes of ALS patients from the CGs’ perspective towards palliative care in advanced
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Investigation of the role of interleukin 27 in the immune regulation of Treg and Th17 cells in neurosyphilis patients Folia Neuropathol. (IF 2.0) Pub Date : 2023-10-16 Wei Zhao, Hao Luo
Introduction: Neurosyphilis (NS) is known as a sexually transmitted disease that is very difficult to diagnose and its diagnosis is delayed. Some studies have suggested that the level of interleukin (IL)-27 decreases in syphilis patients and the level of IL-17 increases in these patients, and these immunological changes can be a therapeutic target for these patients. The present study aims to evaluate
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Clinical characteristics in patients with oculomotor paralysis caused by isolated midbrain infarction Folia Neuropathol. (IF 2.0) Pub Date : 2023-10-13 Eryi Zhao, Daimei Wang, Zhongyan Zhao, Shijun Hu, Xiangying He, Peijian Huang
Introduction: The aim of the study was to investigate the clinical characteristics of isolated oculomotor paralysis (OP) cases caused by pure midbrain infarction (MI) with pupil sparing. Material and methods: Patients with pure MI and pontine infarction (PI) at our hospital were included in this study. We compared the blood pressure and lipid levels between the two groups. And the clinical data and
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Immunological markers of drug resistant epilepsy and its response to immunomodulatory therapy with ACTH in children Folia Neuropathol. (IF 2.0) Pub Date : 2023-10-05 Magdalena Kaczorowska, Edyta Czekuć-Kryśkiewicz, Maciej Dądalski, Katarzyna Kotulska
Introduction: Drug-resistant epilepsy in infancy and childhood is a devastating condition, frequently associated with neuropsychiatric comorbidities. West syndrome is one of the most severe epilepsy syndromes. Adrenocorticotropic hormone (ACTH) treatment is recommended in such cases, but its mechanism of action is still unknown. We prospectively observed levels of selected cytokines in order to identify
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Large haemorrhage within glioblastoma mimicking haemorrhagic stroke and coexistance of meningioma: a case of collision tumours Folia Neuropathol. (IF 2.0) Pub Date : 2023-10-05 Michał Sobstyl, Ewa Nagańska, Piotr Glinka, Teresa Wierzba-Bobrowicz, Albert Acewicz, Aleksandra Kuls-Oszmaniec
Intracranial collision tumours are rare pathologies in which two distinct neoplasms are found in the same location. We present an unusual case of an intracranial collision tumour composed of meningothelial meningioma (CNS WHO G1) and glioblastoma (IDH-wildtype, CNS WHO G4). This collision tumour was found in a 64-year-old man. This patient was hospitalized urgently due to left-sided hemiparesis. The
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Effect of ultra-early intervention of NDT therapy on nerve and motor development in infants at high risk of cerebral palsy Folia Neuropathol. (IF 2.0) Pub Date : 2023-09-28 Meihua Li, Lihua Wang, Shujie Yu, Xuesong Guo, Bingbing Xun, Yu Zhang
Introduction: The aim of the study was to investigate the effect of ultra-early intervention of nerve and motor development in infants at high risk of cerebral palsy. Material and methods: One hundred and twenty cases of infants born in The Affiliated Hospital of Harbin Medical University from January 2017 to January 2019 and diagnosed with high risk of cerebral palsy were included in the observation
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PF4 induces inflammatory response through NF-kB signal pathway in rats with intracerebral haemorrhage Folia Neuropathol. (IF 2.0) Pub Date : 2023-09-27 Na Hu, Ran An, Kun Yu, Yanzhong Chang, Weijuan Gao
Intracerebral haemorrhage (ICH) is a lethal cerebrovascular disorder with a high mortality and morbidity. Although it is a major public health problem, there is no effective treatment for ICH. After ICH, the primary and secondary mechanisms are mentioned when discussing brain injury. The transcription factor, nuclear factor-kappa B (NF-kB), is an important regulator of inflammatory responses. The role
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Cerebral echinococcus that can be confused with brain tumour: a case report Folia Neuropathol. (IF 2.0) Pub Date : 2023-09-14 Şule Göktürk, Yasin Göktürk
Echinococcus is a parasitic disease known as echinococcal zoonosis and is often caused by Echinococcus granulosus. Cerebral echinococcus is extremely rare and has been reported to be less than 1% in the literature and it is more common in the childhood age group. In the case we are going to present, the patient is an 83-year-old male who was admitted to our clinic with complaints of headache and forgetfulness
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Vanillin attenuates oxidative stress and neurochemical balance in MPTP-induced Parkinson’s disease mice by regulating the TLR-4 inflammatory pathway Folia Neuropathol. (IF 2.0) Pub Date : 2023-09-13 Yuan Gao, Jiang Liu, Xiaoyan Wang, Qiang Meng
This study investigated the protective effect of vanillin against Parkinson’s disease (PD). 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP; 30 mg/kg) was administered s.c. for 6 consecutive days to induce PD and mice were treated with vanillin (100 and 200 mg/kg, p.o.) for 15 days. Cognitive, motor and non-motor functions were assessed to evaluate the effect of vanillin in PD mice. Levels of dopamine
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Development and initial experience of a novel classification system for patients with brain stem haemorrhage Folia Neuropathol. (IF 2.0) Pub Date : 2023-09-11 Lu Li, An Ji Wang, Han Bing Zhang, De Shen Wu, Guang Liang Zhuang, Yan Chao Shen, De Shan Gong, Jie Wang
Introduction: There is no uniform classification standard for brain stem haemorrhage. On the basis of previous experience in the treatment of brainstem haemorrhage, this study explored and established a set of criteria for brainstem haemorrhage classification, risk-stratified such patients and guided the selection of treatment options so as to achieve accurate and standardized diagnosis and treatment
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Long-term survival of stage Ib lung adenocarcinoma with postoperative brain oligometastasis: a case report and literature review Folia Neuropathol. (IF 2.0) Pub Date : 2023-09-08 Kai Xu, Xing Feng, Limin Wang, Quan Du, Er Jin
Lung adenocarcinoma remains one of the most frequent and deadly tumour entities. Early-stage lung adenocarcinoma is extremely difficult to detect and is also easy to recur or metastasize after treatment. Since the new adenocarcinoma classification was presented in 2011, several studies have shown that patients with solid and/or micropapillary (S/MP) predominant patterns showed a worse prognosis. Here
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Correlation between blood pressure variability and deep cerebral microbleeds in patients with acute ischemic stroke Folia Neuropathol. (IF 2.0) Pub Date : 2023-09-08 Yaya Bao, Jiayi Gu, Tian Lv, Miao Chen, Ke Zhao, Yue Yang, Dadong Gu
Introduction: To observe the 24-h ambulatory blood pressure characteristics of patients with acute ischemic stroke and explore the correlation between blood pressure variability and strictly deep cerebral microbleeds (CMBs). Material and methods: A convenient sampling method was used to enrol 131 patients with acute ischemic stroke in the Department of Neurology between April 2021 and May 2022. Hospitalised
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The effect of chemotherapies on the crosstalk interaction between CD8 cytotoxic T-cells and MHC-I peptides in the microenvironment of WHO grade 4 astrocytoma Folia Neuropathol. (IF 2.0) Pub Date : 2023-09-06 Nadeem Butt, Maryam Enani, Maryam Alshanqiti, Alaa Alkhotani, Taghreed Alsinani, Mohammed Matoog Karami, Motaz M Fadul, Majid Almansouri, Amber Hassan, Saleh Baeesa, Ahmed K Bamaga, Shadi Alkhayyat, Eyad Faizo, Maher Kurdi
Introduction: CD8+ T-cells and MHC-I have been detected in brain gliomas with a significant outcome. The effect of chemotherapies on the crosstalk interaction between CD8+ T-cells and MHC-I has never been explored. Material and methods: The protein expression profiling of CD8 cytotoxic T-cells and the gene expression assay of MHC-I in 35 patients diagnosed with WHO grade 4 astrocytoma were performed
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Study on the intervention effect of SMG health management in patients with ischemic stroke Folia Neuropathol. (IF 2.0) Pub Date : 2023-08-21 Bu Xu, Tao Wang, Lei Zhu, Xiu-Qun Gong, Yan Gan, Chuan-Qing Yu, Xiang-xia Rong
Introduction: The aim of the study was to explore the clinical effect of brain and heart health managers combined with the “SMG” health management mode on nursing intervention in ischemic stroke patients. Material and methods: A total of 187 ischemic stroke patients divided into 96 patients in the observation group and 91 patients in the control group with the random number table method. The control
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Adipose-derived mesenchymal stem cell exosomes ameliorate spinal cord injury in rats by activating the Nrf2/HO-1 pathway and regulating microglial polarization Folia Neuropathol. (IF 2.0) Pub Date : 2023-08-21 Yi Luo, You-zhi He, Yong-fu Wang, Yu-xia Xu, Li Yang
As of now, there are no satisfactory treatments for spinal cord injury (SCI), so new therapeutic approaches are necessary to be explored. Adipose-derived mesenchymal stem cell exosomes (ADMSC-Exo), delightfully, show remarkable therapeutic effects. Therefore, we try to investigate the effects and mechanisms of ADMSC-Exo on SCI, as well as to provide novel approaches for the treatment of SCI. Adipose-derived
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The protective effect of Wnt3a on inflammatory response in oxygen-glucose deprivation/reoxygenation (OGD/R) astrocyte model Folia Neuropathol. (IF 2.0) Pub Date : 2023-08-04 Su-Qin Chen, Ang Li, Min-Yan Feng, Wen-Qing Zhong, Liu Yang, Xiao-Yu Chen, Xing-Er Wu
Involving in the immune response after cerebral infarction, astrocytes could secrete large amounts of pro- and anti-inflammatory factors. The aim of this study is to investigate the effect of Wnt3a intervention on the inflammatory response of oxygen-glucose deprivation (OGD) followed by reoxygenation (OGD/R) astrocyte model, and to provide a new target for immunoprotective treatment of cerebral infarction
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MiR-484 promotes the malignant progression of glioma by inhibiting CDKN2A expression Folia Neuropathol. (IF 2.0) Pub Date : 2023-08-01 Yingrui Gu, Hongbing Lei, Peipei Ma, Yi Chen
Introduction: Cyclin Dependent Kinase Inhibitor 2A (CDKN2A) is involved in glioma progression, but the specific molecular mechanism of CDKN2A in glioma cell migration and invasion needs to be further explored. Material and methods: Data related to CDKN2A expression and glioma overall survival were obtained from The Cancer Genome Atlas (TCGA) database. Then, CDKN2A expression in glioma tissues/cells
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Botulinum neurotoxin-A in a patient with post-stroke spasticity: a neurophysiological study Folia Neuropathol. (IF 2.0) Pub Date : 2023-07-21 Safa Muntadher Fawzi, Farqad Bader Hamdan, Israa F. Jaafar, Gheyath Abd Ali Shallal Al Gawwam
Introduction: Post-stroke spasticity (PSS) is a disorder of the sensory-motor control, leading to upper motor neuron lesions manifesting either as intermittent or sustained involuntary activation of muscles. Botulinum neurotoxin-A (BoNT-A) is mostly utilized in a variety of therapeutic indications, and it is effective and safe in the management of focal PSS in the rehabilitation scenario. The study
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Incidence and morphology of secondary TDP-43 proteinopathies: Part 2 Folia Neuropathol. (IF 2.0) Pub Date : 2023-07-14 Albert Acewicz, Tomasz Stępień, Paulina Felczak, Sylwia Tarka, Teresa Wierzba-Bobrowicz
Transactivation (TAR) DNA binding protein 43 kDa (TDP-43) inclusions frequently occur as a comorbid pathology in several neurodegenerative disorders, including Alzheimer’s disease, Huntington’s disease, Lewy body disease, and progressive supranuclear palsy, and may appear in association with nondegenerative neurological etiology, for example neoplastic, paraneoplastic, traumatic, or infectious. Relationships
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BCOR expression in paediatric pineoblastoma Folia Neuropathol. (IF 2.0) Pub Date : 2023-07-14 Joanna Trubicka, Maria Łastowska, Agnieszka Karkucińska-Więckowska, Magdalena Niemira, Maria Ejmont, Agnieszka Sowińska, Maciej Pronicki, Ewa Matyja, Wiesława Grajkowska
BCOR is expressed in a new brain tumour entity, i.e. ‘CNS tumour with BCOR internal tandem duplication’ (HGNET BCOR) but not in several other high grade paediatric brain tumours investigated. Immunohistochemical detection of BCOR expression may therefore serve as a potential diagnostic marker. Nevertheless, in rare paediatric glioma cases recurrent EP300-BCOR fusions were detected, which resulted in
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Osteopontin expression and the effect of anti-VLA-4 mAb treatment in experimental autoimmune encephalomyelitis, a mouse model of multiple sclerosis Folia Neuropathol. (IF 2.0) Pub Date : 2023-07-12 Grażyna Pyka-Fościak, Jan A. Litwin, Grzegorz J. Lis
Introduction: Osteopontin (OPN) is involved in the pathogenesis of multiple sclerosis and its animal model, experimental autoimmune encephalomyelitis (EAE). The aim of this study was to investigate the expression of OPN in spinal cords of mice in the successive phases of EAE, to compare it with the density of inflammatory cells, oligodendrocytes and with the expression of interleukin (IL)-17A and to
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The role of synthetic ligand of PPARα in regulation of transcription of genes related to mitochondria biogenesis and dynamic in an animal model of Alzheimer’s disease Folia Neuropathol. (IF 2.0) Pub Date : 2023-07-14 Sylwia Żulińska, Anna K. Strosznajder, Joanna B. Strosznajder
Peroxisome proliferator-activated receptors α (PPARα) are members of the nuclear receptors family and a very potent transcription factor engaged in the regulation of lipid and energy metabolism. Recent data suggest that PPARα could play an important role in the pathomechanism of Alzheimer’s disease (AD) and other neuropsychiatric disorders. This study focused on the effect of a synthetic ligand of
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ADAMTS8 inhibits glioma development in vitro and in vivo Folia Neuropathol. (IF 2.0) Pub Date : 2023-07-14 Baosheng Zhou, Yong Liu, Guangshuo Ma, Xiuyu Wang, Binge Chang, Hongwei Lu, Xuequan Feng
Introduction: In recent years, novel RNAs have been revealed to be regulators in glioma. ADAMTS8 has been reported to be reduced in brain tumours. In this study, we aimed to explore the role of ADAMTS8 in glioma. Material and methods: Online bioinformatic tools, Gepia and Chinese Glioma Genome Atlas database (CGGA) were used to analyse the differential expression of ADAMTS8, overall survival and disease-free
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Astragaloside IV inhibits experimental autoimmune encephalomyelitis by modulating the polarization of both microglia/macrophages and astrocytes Folia Neuropathol. (IF 2.0) Pub Date : 2023-07-04 Jingwen Yu, Bingtao Mu, Minfang Guo, Chunyun Liu, Tao Meng, Yuqing Yan, Lijuan Song, Jiezhong Yu, Gajendra Kumar, Cungen Ma
Astragaloside IV (AST IV), a major saponin component and active ingredient isolated from Astragalus membranaceus, has been well known to exhibit neuroprotective effects on diverse models of neurological diseases. Accumulating evidence suggests that dynamic balance of microglia/macrophages and astrocytes plays a vital role in neuroprotection and remyelination. However, dysregulation of microglia/macrophages
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Possible association between cerebral white matter atrophy and impaired performance of activities of daily living in patients with Parkinson’s disease Folia Neuropathol. (IF 2.0) Pub Date : 2023-05-31 Zhi-Hao Lu, Yang-Kun Chen, Xiao-Li Fu, Qi-Ting Chen, Shu-Lan Yuan
Introduction: The contribution of brain abnormalities in patients with Parkinson’s disease (PD) to impaired functional status remains uncertain. Our study assessed whether global and regional brain structural abnormalities are associated with impaired performance of activities of daily living (ADL) in PD patients. Material and methods: A retrospective analysis was conducted of 46 patients with PD,
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LncRNA FTX ameliorates neuropathic pain by targeting miR-320a in a rat model of chronic constriction injury Folia Neuropathol. (IF 2.0) Pub Date : 2023-05-22 Zhisheng Lu, Yijue Zhang, Yunze Li
Introduction: Long non-coding RNAs (lncRNAs) participate in the process of neuropathic pain (NP). Herein, the goal of this research was to examine the roles of lncRNA five prime to XIST (FTX) in influencing chronic constriction injury (CCI)-induced NP. Material and methods: We have established a rat CCI model to simulate NP in vivo. Reverse transcription-quantitative PCR (RT-qPCR) was used to detect
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Nanotechnology-based cancer chemoprevention in glioblastoma Folia Neuropathol. (IF 2.0) Pub Date : 2023-05-22 Aima Adylova, Gulnara Kapanova, Zaure Datkhayeva, Karlygash Raganina, Gulnur Tanbayeva, Kaini Baigonova
Brain tumours are heterogeneous and are classified comprehensively into molecular subtypes based on genetic alterations. Glioblastoma rapid progression, drug resistance, and recurrence have been scientifically linked to several factors, including its rapid growth rate, loss of apoptosis, pro-survival signalling, molecular heterogeneities and hallmark features to infiltrate vital brain structures. Because
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Protective effects of fisetin in an Aβ1-42-induced rat model of Alzheimer’s disease Folia Neuropathol. (IF 2.0) Pub Date : 2023-05-22 Yunting Wang, Xueling Wu, Wujiang Ren, Yanxia Liu, Xueling Dai, Shuo Wang, Qing Huo, Yaxuan Sun
Alzheimer’s disease (AD) is a chronic, neurodegenerative disorder that affects the central nervous system and is found predominantly in elderly populations. As amyloid b protein (Ab) is one of the key players responsible for the pathogenesis of AD, we sought to investigate the protective effects of fisetin in an Ab1-42-induced rat model of AD. In this model, the protective effects of fisetin on learning
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Knockdown of long non-coding RNA LINC00941 suppressed cell proliferation, colony-formation, and migration of human glioblastoma cell lines Folia Neuropathol. (IF 2.0) Pub Date : 2023-05-22 Yuan Wang, Shuwei Wang, Haibo Wang, Di Zhao, Haoliang Zhang, Huan Liu, Jianzhong Cui, Kaijie Wang
Introduction: Glioblastoma (GBM) represents the most common and lethal type of primary brain tumour in adults, and due to its high invasiveness, treatment of GBM remains challenging. This work is aimed to elucidate the role of LINC00941 in GBM. Material and methods: Expression of LINC00941 in two GBM cell lines U251 and U87-MG was knocked down using siRNA. Cell proliferation and colony-formation ability
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The influence of COVID-19 on the treatment of patients with acute ischemic stroke: a retrospective observational study Folia Neuropathol. (IF 2.0) Pub Date : 2023-04-27 Wei Chen, Fangju Lin, Wei Zhao, Baoling Yang, Weihua Jia
Introduction: Since December 2019, coronavirus 2019 (COVID-19) has rapidly spread to become a global pandemic, exerting a great pressure on medical staff worldwide. This study aimed to observe whether COVID-19 influenced the diagnosis and treatment of ischemic stroke (IS). Material and methods: This study retrospectively analysed the clinical data (number of emergencies, time from onset to treatment
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Correlation analysis between plasma fibrinogen and nerve electrophysiological changes in type 2 diabetic peripheral neuropathy Folia Neuropathol. (IF 2.0) Pub Date : 2023-04-24 Weili Gu, Zhenhong Li, Xiaobei Zhu, Xiaojuan Huang, Dengfeng Zhang, Yu Jiang, Zhaotian Ye, Ying Sun, Pian Ao, Xinyue Zhang, Qimin Cao, Li Wei, Shaojun Wang
Introduction: The aim of the study was to investigate the pathogenesis of diabetic peripheral neuropathy (DPN) and the value of fibrinogen (FIB) in the early diagnosis of DPN. Material and methods: A total of 121 patients with type 2 diabetes mellitus (T2DM) and DPN hospitalized in the Endocrinology Department of the 923 Hospital of the People’s Liberation Army of China were randomly selected between
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LncRNA FOXD3-AS1/miR-128-3p axis-mediated IGF2BP3 in glioma stimulates cancer angiogenesis and progression Folia Neuropathol. (IF 2.0) Pub Date : 2023-04-21 Hongxin Zhao, Yuyu Wang, Chuandong Liang, Mingxiang Xie
Introduction: The aim of the study was to research the mechanism by which IGF2BP3 regulates glioma progression as well as its upstream regulatory axis. Material and methods: The researched mRNA was determined using differential expression analysis based on bioinformatics data, and its upstream miRNAs and lncRNAs were predicted. Interaction between genes we researched was identified by dual-luciferase
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Spontaneous intracranial hypotension: a case series and literature review Folia Neuropathol. (IF 2.0) Pub Date : 2023-04-06 Michele Pistacchi, Andrea Pezzato, Roberta Rudà, Manuela Gioulis, Franco Contin, Federica Fragiacomo, Sandro Zambito Marsala
Spontaneous intracranial hypotension (SIH) is a condition of negative intracranial pressure resulting from cerebrospinal fluid (CSF) leakage from the dural sac and is a well-known cause of orthostatic headache. Diagnosis and management can be difficult, often requiring coordination between multiple disciplines. Low CSF pressure and diffuse meningeal enhancement on brain MRI are the major instrumental
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HSF1 inhibits microglia activation to attenuate neuroinflammation via regulating miR-214-3p and NFATc2 in Parkinson’s disease Folia Neuropathol. (IF 2.0) Pub Date : 2023-03-24 Yuangao Liao, Yong Gu, Jinhua Wang, Yu Tian, Xiaohong Ni, Lei Zhou, Ye Ye, Guangming Xia
Parkinson’s disease (PD) is characterized by microglia activation that leads to neuroinflammation. Heat shock transcription factor 1 (HSF1) is known to exert neuroprotective effects on neurodegenerative diseases. This study sought to analyse the role and mechanism of HSF1 in PD-induced neuroinflammation. The PD mouse models were established using 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)
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Effects of intrathecally administered interferon α on chronic constriction injury model rats’ mechanical pain threshold and G protein expression in the spinal cord Folia Neuropathol. (IF 2.0) Pub Date : 2023-03-24 Yaoyao Guo, Zhaoxia Xue, Baozhong Yang, Liwei Liu, Peng Zhang, Jin Shi, Xiurong Fu, Yanming Xue, Yanfei Hao, Gaoliang Ji
Introduction: The aim of the study was to explore the analgesic mechanism of effects of intrathecally administered interferon a (IFN-a) on chronic constriction injury (CCI) model rats. Material and methods: 24 rats were divided into 6 groups, with 4 rats in each group, including the negative control group (Group N, no operation or treatment), the sham operation group (Group S, only the left sciatic
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Cognitive impairment of MRL mice is related to NMDA receptor-mediated inflammatory response and production of adhesion molecules in MRL/lpr mice-derived micro-vascular endothelial cells Folia Neuropathol. (IF 2.0) Pub Date : 2023-03-17 Xiaoyan Guan, Jingyuan Wang
Systemic lupus erythematosus (SLE) is a chronic recurrent autoimmune disease affecting almost all organs. This study was conducted to investigate cognitive impairment of SLE mice (MRL/lpr mice), and explore associated pathological mechanism. Behavior tests (open-field test, elevated plus-maze test, forced swimming test, sucrose preference test, and Morris water maze test) were conducted in MRL/MPJ
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Antioxidant properties of Trifolium resupinatum and its therapeutic potential for Alzheimer’s disease Folia Neuropathol. (IF 2.0) Pub Date : 2023-03-07 Shayan Mardi, Zahra Salemi, Mohammad-Reza Palizvan
Introduction: Alzheimer’s disease (AD) is the most common cause of dementia and is characterized by a progressive deterioration in cognitive function, which typically begins with impairment in memory. Persian clover (Trifolium resupinatum) is an annual plant found in central Asia. Due to its contents (high flavonoid and isoflavones), extensive researches have been done on its therapeutic properties
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LINC00470 represses cell autophagy and cisplatin sensitivity of glioma via suppressing PTEN expression Folia Neuropathol. (IF 2.0) Pub Date : 2023-02-23 Biyin Chen, Wenwu Wang, Fangfeng Lin, Shuping Shi, Shunjie Ou, Yunqiu Yu
Introduction: Glioma is one of primary brain tumours which has the worst clinical prognoses of patients. As an alternative chemotherapeutic drug for malignant glioma, the therapeutic effect of cisplatin (CDDP) is devastatingly affected due to resistance in patients. In this study, we investigated the effect of LINC00470/PTEN on the CDDP sensitivity of glioma cells. Material and methods: Differentially
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Knockdown of lncRNA BDNF-AS alleviates isoflurane-induced neuro-inflammation and cognitive dysfunction through modulating miR-214-3p Folia Neuropathol. (IF 2.0) Pub Date : 2023-02-17 Lin Wang, Yajun Mao, Yugang Lu, Yawei Yuan, Yanwu Jin
Introduction: As one of the most commonly used anesthetics, isoflurane has been demonstrated to possess a variety of protective effects. However, its’ neurological impaired effect should be considered during clinical application. Roles of lncRNA BDNF-AS (BDNF-AS) and miR-214-3p in isoflurane-injured microglia and rats were investigated in this study, aiming to disclose the mechanism of isoflurane damage
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Exercise attenuates neuronal degeneration in Parkinson’s disease rat model by regulating the level of adenosine 2A receptor Folia Neuropathol. (IF 2.0) Pub Date : 2023-02-16 Ruizhi Li, Shasha Jin, Jiangen He, Yanxia Peng, Longfei Wei, Lei Gu
Parkinson’s disease occurs due to loss of dopaminergic neurons, which alters the behavioural changes. The present study evaluates the effect of exercise on neurodegeneration against Parkinson’s disease (PD) rat model and postulates its effect on novel molecular pathway. Rotenone was administered at 1 mg/kg s.c. every 48 h for 18 days for the induction of PD and exercise was given to rats for a period
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5-HT and S100β values in evaluating severity of cognitive impairment after traumatic brain injury Folia Neuropathol. (IF 2.0) Pub Date : 2023-02-16 Guan Jin, Yanhao Yang, Feng Bi, Mingyan Yang, Yinhua Ma
Introduction: The aim of the study was to investigate the relationship between serum serotonin (5-HT) and central nervous system specific protein S100b application value in evaluating the severity of cognitive impairment after traumatic brain injury (TBI). Material and methods: 102 patients with TBI treated in Jilin Neuropsychiatric Hospital from June 2018 to October 2020 were selected. According to
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The neuroprotective effect of Dl-3-n-butylphthalide in epileptic rats via inhibiting endoplasmic reticulum stress Folia Neuropathol. (IF 2.0) Pub Date : 2023-01-31 Shuang Tian, Zhenzhen Qu, Huifang Cao, Xiaoli Niu, Qi Qiao, Bing Zhang, Lijing Jia, Weiping Wang
Introduction: The purpose of this study is to investigate whether Dl-3-n-Butylphthalide (NBP) has a neuroprotective effect on pilocarpine-induced epileptic (EP) rats through endoplasmic reticulum stress (ERS)-mediated apoptosis. Material and methods: The Sprague-Dawley rats were divided into four groups: control (CON), EP, EP + NBP60 (NBP 60 mg/kg) and EP + NBP120 (NBP 120 mg/kg) groups. After the
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Review of neuroimaging research progress of cerebral small vessel disease Folia Neuropathol. (IF 2.0) Pub Date : 2023-01-31 Junlin Wang, Bin Wang, Kexin Wang
Cerebral small vessel disease (cSVD) is a disease defined by clinical symptoms and neuroimaging, which often causes a series of pathophysiological changes, blood-brain barrier destruction, brain tissue ischemia and involves cerebral arterioles, capillaries and venules. The exact pathogenesis of cSVD is unclear and there is no specific prevention and treatment for this potentially high disability rate
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Loss of lncRNA UCA1 ameliorates the injury managed by cerebral ischemia-reperfusion by sponging miR-18a-5p Folia Neuropathol. (IF 2.0) Pub Date : 2023-01-09 Jingyi Yan, Yang Gao, Jianyuan Huang, Wei Gao, Yang Li, Baishun Lin
Introduction: Acute ischemic stroke (AIS) is a disease with high morbidity and mortality in the clinic. The current experiments aimed to study the effects of UCA1 interfering miR-18a-5p on cerebral ischemia-reperfusion (CI/R). Material and methods: For rat models undergoing middle cerebral artery infarction (MCAO) surgery, the expression of UCA1 and miR-18a-5p was evaluated by qRT-PCR, and underlying
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Metastases to cranial base meningiomas. Clinical presentations and surgical outcomes. Literature overview Folia Neuropathol. (IF 2.0) Pub Date : 2022-12-30 Anna Rzehak, Michał Sobstyl, Piotr Bojarski
Tumour-to-meningioma metastasis (TTMM) is an uncommon phenomenon, however repeatedly found in the literature. Meningiomas occur to be the most frequent target of metastatic expansion of systemic cancers. Meningiomas often vary in symptoms and treatment, and this largely depends on the tumour location. Due to their variable locations, they can be classified as convexity meningiomas, which includes falcine
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Prenatal exposure to valproic acid induces alterations in the expression and activity of purinergic receptors in the embryonic rat brain Folia Neuropathol. (IF 2.0) Pub Date : 2022-12-30 Lidia Babiec, Anna Wilkaniec, Agata Adamczyk
Purinergic signalling is involved in the control of several processes related to brain development, such as neurogenesis and gliogenesis, migration and differentiation of neuronal precursors, synaptogenesis and synaptic elimination to achieve a fully wired and efficient mature brain. Therefore, any deregulation of purine-dependent signalling mediated by stimulation of specific adenosine and purinergic
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Impact of inflammation-related degenerative changes on the wall strength of unruptured intracranial aneurysms: a pilot study Folia Neuropathol. (IF 2.0) Pub Date : 2022-12-30 Leszek Lombarski, Przemysław Kunert, Sylwia Tarka, Tomasz Stępień, Dominik Chutorański, Sławomir Kujawski, Andrzej Marchel
Introduction Saccular intracranial aneurysm (sIA) rupture is a serious cerebrovascular event associated with inflammatory destructive processes leading to gradual weakening of the sIA wall. The aim of the present study was to identify the morphological and histological determinants for low wall strength in unruptured sIAs harvested from autopsy subjects. Material and methods A total of eight single