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Fibroblast matrix implants—a better alternative for incisional hernia repair? Biomed. Mater. (IF 4.0) Pub Date : 2024-04-24 Siufui Hendrawan, Jennifer Lheman, Ursula Weber, Christian Eugen Oberkofler, Astheria Eryani, René Vonlanthen and Hans Ulrich Baer
The standard surgical procedure for abdominal hernia repair with conventional prosthetic mesh still results in a high recurrence rate. In the present study, we propose a fibroblast matrix implant (FMI), which is a three-dimensional (3D) poly-L-lactic acid scaffold coated with collagen (matrix) and seeded with fibroblasts, as an alternative mesh for hernia repair. The matrix was seeded with fibroblasts
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Fe3O4-Cy5.5-trastuzumab magnetic nanoparticles for magnetic resonance/near-infrared imaging targeting HER2 in breast cancer Biomed. Mater. (IF 4.0) Pub Date : 2024-04-24 Qiangqiang Yin, Xiaolong Gao, Hao Zhang, Zhichen Zhang, Xiaoyang Yu, Jialong He, Guangyue Shi and Liguo Hao
This study developed a probe Fe3O4-Cy5.5-trastuzumab with fluorescence and magnetic resonance imaging functions that can target breast cancer with high HER2 expression, aiming to provide a new theoretical method for the diagnosis of early breast cancer. Fe3O4-Cy5.5-trastuzumab nanoparticles were combined with Fe3O4 for T2 imaging and Cy5.5 for near-infrared imaging, and coupled with trastuzumab for
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Spinning with exosomes: electrospun nanofibers for efficient targeting of stem cell-derived exosomes in tissue regeneration Biomed. Mater. (IF 4.0) Pub Date : 2024-04-21 Ritu Raj, Parinita Agrawal, Utkarsh Bhutani, Tuhin Bhowmick and Arun Chandru
Electrospinning technique converts polymeric solutions into nanoscale fibers using an electric field and can be used for various biomedical and clinical applications. Extracellular vesicles (EVs) are cell-derived small lipid vesicles enriched with biological cargo (proteins and nucleic acids) potential therapeutic applications. In this review, we discuss extending the scope of electrospinning by incorporating
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Preparation and characterization of chitosan/polyvinyl alcohol antibacterial sponge materials Biomed. Mater. (IF 4.0) Pub Date : 2024-04-17 Xue Chen, Jing Xu, Alidha Gafur, Baoyu Chen, Yibo Han, Liyuan Zhang, Lingwen Kong, Guixue Wang and Zhiyi Ye
This study utilized the freeze-drying method to create a chitosan (CS) and polyvinyl alcohol (PVA) sponge. To enhance its antibacterial properties, curcumin and nano silver (Cur@Ag) were added for synergistic antibacterial. After adding curcumin and nano silver, the mechanical properties of the composite sponge dressing (CS-PVA-Cur@Ag) were improved. The porosity of the composite sponge dressing was
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Preparation of celecoxib loaded bioactive glass chitosan composite hydrogels: a simple approach for therapeutic delivery of NSAIDs Biomed. Mater. (IF 4.0) Pub Date : 2024-04-17 Azra Jalal, Sana Ahmad, Asma Tufail Shah, Tousif Hussain, Hafiz Awais Nawaz and Saleha Imran
Arthritis causes inflammatory damage to joints and connective tissues. In the treatment of arthritis, precise and controlled drug delivery to the target site is among the frontline research approaches. In the present research work, celecoxib drug and bioactive glass incorporated chitosan hydrogels were fabricated by the freeze gelation method. Fourier transform infrared spectroscopy, scanning electron
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Surface engineered nanodiamonds: mechanistic intervention in biomedical applications for diagnosis and treatment of cancer Biomed. Mater. (IF 4.0) Pub Date : 2024-04-14 Tanima Dey, Anushikha Ghosh, Arka Sanyal, Chelsea Josephine Charles, Sahas Pokharel, Lakshmi Nair, Manjari Singh, Santanu Kaity, Velayutham Ravichandiran, Kulwinder Kaur and Subhadeep Roy
In terms of biomedical tools, nanodiamonds (ND) are a more recent innovation. Their size typically ranges between 4 to 100 nm. ND are produced via a variety of methods and are known for their physical toughness, durability, and chemical stability. Studies have revealed that surface modifications and functionalization have a significant influence on the optical and electrical properties of the nanomaterial
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Development of phytosterol-loaded silver nanoparticles for ameliorating haemorrhoidal complications via the AMPK pathway—a mechanistic approach Biomed. Mater. (IF 4.0) Pub Date : 2024-04-10 Tarkeshwar Dubey, Kancharla Bhanukiran and Siva Hemalatha
The aim of the current study was to synthesize silver nanoparticles (PLSNPs) using green technology by means of phytosterol-enriched fractions from Blumea lacera extracts (EAF) and evaluate their toxicological and anti-haemorrhoidal potential. The average size of the synthesized particles was found to be 85.64 nm by scanning electron microscopy and transmission electron microscopy. Energy dispersive
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Bone morphogenetic protein-2 loaded triple helix recombinant collagen-based hydrogels for enhancing bone defect healing Biomed. Mater. (IF 4.0) Pub Date : 2024-04-10 Huixia He, Fan Yang, Shanshan Zhang, Zhao Liu, Zaiman Liu, Linghui Yu and Jianxi Xiao
The development of efficacious bone substitute biomaterials remains a major challenge for research and clinical surgical. Herein, we constructed triple helix recombinant collagen (THRC) -based hydrogels loading bone morphogenetic protein-2 (BMP-2) to stimulate bone regeneration in cranial defects. A series of in situ forming hydrogels, denoted as THRC-oxidized carboxymethylcellulose (OCMC)-N-succinyl-chitosan
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The effect of magnesium ions synergistic with mineralized collagen on osteogenesis/angiogenesis properties by modulating macrophage polarization in vitro and in vivo Biomed. Mater. (IF 4.0) Pub Date : 2024-04-10 Chang Liu, Nan Ma, Changan Sun, Xuecheng Shen, Jinwei Li and Chengyue Wang
In bone tissue engineering, the bone immunomodulatory properties of biomaterials are critical for bone regeneration, which is a synergistic process involving physiological activities like immune response, osteogenesis, and angiogenesis. The effect of the macrophage immune microenvironment on the osteogenesis and angiogenesis of various material extracts was examined in this experiment using Mg2+ and
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Magnetic biocomposite scaffold based on decellularized tendon ECM and MNP-deposited halloysite nanotubes: physicochemical, thermal, rheological, mechanical and in vitro biological evaluations Biomed. Mater. (IF 4.0) Pub Date : 2024-04-04 Aysel Koç-Demir, Ayşe Eser Elçin and Yaşar Murat Elçin
The development of new three-dimensional biomaterials with advanced versatile properties is critical to the success of tissue engineering (TE) applications. Here, (a) bioactive decellularized tendon extracellular matrix (dECM) with a sol-gel transition feature at physiological temperature, (b) halloysite nanotubes (HNT) with known mechanical properties and bioactivity, and (c) magnetic nanoparticles
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Enhancing osteoblast proliferation and bone regeneration by poly (amino acid)/selenium-doped hydroxyapatite Biomed. Mater. (IF 4.0) Pub Date : 2024-04-04 Xiaobo Wei, Ziyue Zhang, Lei Wang, Lin Yan, Yonggang Yan, Cheng Wang, Haitao Peng, Xiaoxia Fan
Among various biomaterials employed for bone repair, composites with good biocompatibility and osteogenic ability had received increasing attention from biomedical applications. In this study, we doped selenium (Se) into hydroxyapatite (Se-HA) by the precipitation method, and prepared different amounts of Se-HA-loaded poly (amino acid)/Se-HA (PAA/Se-HA) composites (0, 10 wt%, 20 wt%, 30 wt%) by in-situ
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Assessment of hemostatic ability of biomaterial based on chitosan and Eclipta prostrata L. extract Biomed. Mater. (IF 4.0) Pub Date : 2024-04-04 Nguyen Ngoc Linh, Vu Quoc Manh, La Chau Giang, Nguyen Thuy Chinh, Hoang Tran Dung, Tran Thi Thuy Duong, Thai Hoang, Vu Quoc Trung
The biomaterials based on chitosan and Eclipta prostrata L. extract have been prepared by microemulsion method and solution method (with and without sodium tripolyphosphate (STPP) as a cross-linking agent). The main component in Eclipta prostrata L. extract is flavonoid groups. The structure of the chitosan/extract biomaterials was studied by infrared spectroscopy. The chitosan/extract biomaterial
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Adipose tissue reconstruction facilitated with low immunogenicity decellularized adipose tissue scaffolds Biomed. Mater. (IF 4.0) Pub Date : 2024-04-03 Xun Yang, Lijuan Jin, Miaomiao Xu, Xiao Liu, Zhikai Tan, Lijun Liu
There is currently an urgent need to develop engineered scaffolds to support new adipose tissue formation and facilitate long-term maintenance of function and defect repair to further generate prospective bioactive filler materials capable of fulfilling surgical needs. Herein, adipose regeneration methods were optimized and decellularized adipose tissue (DAT) scaffolds with good biocompatibility were
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Measuring cell proliferation in bioprinting research Biomed. Mater. (IF 4.0) Pub Date : 2024-04-03 Sophie Schweinitzer, Masoumeh Jahani Kadousaraei, Mehmet Serhat Aydin, Kamal Mustafa, Ahmad Rashad
Tissue-like constructs, intended for application in tissue engineering and regenerative medicine, can be produced by three-dimensional (3D) bioprinting of cells in hydrogels. It is essential that the viability and proliferation of the encapsulated cells can be reliably determined. Methods currently used to evaluate cell proliferation, such as quantification of DNA and measurement of metabolic activity
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Synergistic effects of calcium silicate/zinc silicate dual compounds and in-situ interconnected pores on promoting bone regeneration of composite scaffolds Biomed. Mater. (IF 4.0) Pub Date : 2024-04-02 Guowen Qian, Tingting Wu, Zhaozhen Wang, Bo Yu, Jiandong Ye
Rapid bone regeneration in implants is important for successful transplantation. In this regard, we report the development of calcium silicate/zinc silicate (CS/ZS) dual-compound-incorporated calcium phosphate cement (CPC) scaffolds with a three-dimensional poly (lactic-co-glycolic acid) network that synergistically promote bone regeneration. In vitro results demonstrated that the incorporation of
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Fabrication and application of salicin-polycaprolactone 3D-printed scaffold in the healing of femur bone defects Biomed. Mater. (IF 4.0) Pub Date : 2024-03-28 Hanieh Jalali, Milad Salemian, Mohammad Nabiuni, Homa Mohseni Kouchesfehani, Latifeh Karimzadeh Bardei, Carl Gregory
Polycaprolactone (PCL) is a suitable material for bone repair due to good biocompatibility and mechanical properties. However, low bioactivity and hydrophobicity pose major challenges for its biomedical applications. To overcome these limitations, PCL-based scaffolds loaded with bioactive agents have been developed. Salicin (Sal) is an anti-inflammatory and analgesic herbal glycoside with osteogenic
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PEGylation of NIR Cd0.3Pb0.7S aqueous quantum dots for stabilization and reduction of nonspecific binding to cells Biomed. Mater. (IF 4.0) Pub Date : 2024-03-28 Alexandra Jednorski, Ozgun Acar, Wan Y Shih, Wei-Heng Shih
Cd0.3Pb0.7S (CdPbS) aqueous quantum dots (AQDs) made with 3-mercaptoproprionic acid (MPA) as a ligand have the advantages of emitting near-infrared light, well above 800 nm, that completely circumvents interference from tissue autofluorescence and have significant amounts of ligands for bioconjugation. However, retaining the right amount of MPA became a challenge when using CdPbS AQDs for bioimaging
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Enhancement of skin tumor laser hyperthermia with Ytterbium nanoparticles: numerical simulation Biomed. Mater. (IF 4.0) Pub Date : 2024-03-28 Zamrood A Othman, Yousif M Hassan, Abdulkarim Y Karim
Laser hyperthermia therapy (HT) has emerged as a well-established method for treating cancer, yet it poses unique challenges in comprehending heat transfer dynamics within both healthy and cancerous tissues due to their intricate nature. This study investigates laser HT therapy as a promising avenue for addressing skin cancer. Employing two distinct near-infrared (NIR) laser beams at 980 nm, we analyze
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Tumor targeted nanohybrid for dual stimuli responsive and NIR amplified photothermal/photo-induced thermodynamic/chemodynamic combination therapy Biomed. Mater. (IF 4.0) Pub Date : 2024-03-25 Neha Mehrotra, Kaushik Pal
The combination of photodynamic (PDT) and chemodynamic therapy (CDT) for cancer treatment has gathered a lot of attention in recent years. However, its efficacy is severely limited by elevated levels of hypoxia and glutathione (GSH) in the tumor microenvironment (TME). Multifunctional nanoparticles that can help remodel the TME while facilitating PDT/CDT combination therapy are the need of the hour
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Targeted exosome-based nanoplatform for new-generation therapeutic strategies Biomed. Mater. (IF 4.0) Pub Date : 2024-03-25 Wenjing Yin, Hongyin Ma, Yang Qu, Siji Wang, Ruoyu Zhao, Yi Yang, Zhen-Ni Guo
Exosomes, typically 30–150 nm in size, are lipid-bilayered small-membrane vesicles originating in endosomes. Exosome biogenesis is regulated by the coordination of various mechanisms whereby different cargoes (e.g. proteins, nucleic acids, and lipids) are sorted into exosomes. These components endow exosomes with bioregulatory functions related to signal transmission and intercellular communication
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Long-term observation of polycaprolactone small-diameter vascular grafts with thickened outer layer and heparinized inner layer in rabbit carotid arteries Biomed. Mater. (IF 4.0) Pub Date : 2024-03-22 Yonghao Xiao, Xin Jin, Liujun Jia, Jubo Li, Baojie Zhang, Xue Geng, Lin Ye, Ai-ying Zhang, Yongquan Gu, Zeng-guo Feng
In our previous study, the pristine bilayer small-diameter in situ tissue engineered vascular grafts (pTEVGs) were electrospun from a heparinized polycaprolactone (PCL45k) as an inner layer and a non-heparinized PCL80k as an outer layer in the thickness of about 131 μm and 202 μm, respectively. However, the hydrophilic enhancement of inner layer stemmed from the heparinization accelerated the degradation
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Biopolymeric corneal lenticules by digital light processing based bioprinting: a dynamic substitute for corneal transplant Biomed. Mater. (IF 4.0) Pub Date : 2024-03-21 Utkarsh Bhutani, Namit Dey, Suvro Kanti Chowdhury, Neha Waghmare, Rita Das Mahapatra, Kamalnath Selvakumar, Arun Chandru, Tuhin Bhowmick, Parinita Agrawal
Digital light processing (DLP) technology has gained significant attention for its ability to construct intricate structures for various applications in tissue modeling and regeneration. In this study, we aimed to design corneal lenticules using DLP bioprinting technology, utilizing dual network bioinks to mimic the characteristics of the human cornea. The bioink was prepared using methacrylated hyaluronic
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Oxidized alginate-gelatin (ADA-GEL)/silk fibroin/Cu-Ag doped mesoporous bioactive glass nanoparticle-based hydrogels for potential wound care treatments Biomed. Mater. (IF 4.0) Pub Date : 2024-03-20 Memoona Akhtar, Arooba Nazneen, Muhammad Awais, Rabia Hussain, Ahmad Khan, Muhammad Irfan, Egemen Avcu, Muhammad Atiq Ur Rehman, Aldo R Boccaccini
The present work focuses on developing 5% w/v oxidized alginate (alginate di aldehyde, ADA)-7.5% w/v gelatin (GEL) hydrogels incorporating 0.25% w/v silk fibroin (SF) and loaded with 0.3% w/v Cu-Ag doped mesoporous bioactive glass nanoparticles (Cu-Ag MBGNs). The microstructural, mechanical, and biological properties of the composite hydrogels were characterized in detail. The porous microstructure
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Niosomes containing paclitaxel and gold nanoparticles with different coating agents for efficient chemo/photothermal therapy of breast cancer Biomed. Mater. (IF 4.0) Pub Date : 2024-03-13 Masuomeh Kaveh Zenjanab, Parvin Samadi Pakchin, Marziyeh Fathi, Elaheh Dalir Abdolahinia, Khosro Adibkia
Breast cancer (BC) is one of the most common cancers in women, and chemotherapy is usually used to overcome this cancer. To improve drug delivery to cancer sites and reduce their side effects, nanocarriers such as niosomes (NIOs) are used. Moreover, a combination of other therapeutic methods like photothermal therapy (PTT) can help to enhance the chemotherapy effect. The aim of this research is the
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Eco-friendly synthesis of mesoporous bioactive glass ceramics and functionalization for drug delivery and hard tissue engineering applications Biomed. Mater. (IF 4.0) Pub Date : 2024-03-12 Sobia Tabassum, Muhammad Saqib, Madeeha Batool, Faiza Sharif, Mazhar Amjad Gilani, Olivier Huck
Hard tissue regenerative mesoporous bioactive glass (MBG) has traditionally been synthesized using costly and toxic alkoxysilane agents and harsh conditions. In this study, MBG was synthesized using the cheaper reagent SiO2 by using a co-precipitation approach. The surface properties of MBG ceramic were tailored by functionalizing with amino and carboxylic groups, aiming to develop an efficient drug
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Ursolic acid loaded tri-block copolymer nanoparticles based on triphenylphosphine for mitochondria-targeted cancer therapy Biomed. Mater. (IF 4.0) Pub Date : 2024-03-12 Jieqiong Ding, Jie Tan, Xiaohang Peng, Liyuan Cheng, Weiling Huang, Binhua Luo
A novel biodegradable amphiphilic triblock copolymer, polyphosphate, polyethylene glycol, and polylactic acid (PAEEP-PEG-PLLA), was synthesized by twice ring-opening polymerization and triphenylphosphine (TPP) was grafted onto the block copolymer to synthesize a carrier material TPP-PAEEP-PEG-PLLA, which was identified by 1H-nuclear magnetic resonance (1H-NMR) spectroscopy. The TPP-PAEEP-PEG-PLLA nanoparticles
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Investigation of anti-adhesion ability of 8-arm PEGNHS-modified porcine pericardium Biomed. Mater. (IF 4.0) Pub Date : 2024-03-12 Sreypich Say, Mika Suzuki, Yoshihide Hashimoto, Tsuyoshi Kimura, Akio Kishida
In post-adhesion surgery, there is a clinical need for anti-adhesion membranes specifically designed for the liver, given the limited efficacy of current commercial products. To address this demand, we present a membrane suitable for liver surgery applications, fabricated through the modification of decellularized porcine pericardium with 20 KDa hexaglycerol octa (succinimidyloxyglutaryl) polyoxyethylene
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Synthesis and characterization of 3-in-1 multifunctional lipiodol-doped Fe3O4@Poly (diallyl isophthalate) microspheres for arterial embolization, chemotherapy, and imaging Biomed. Mater. (IF 4.0) Pub Date : 2024-03-08 Piaoyi Chen, Qinglin Xiao, Zhaoxiong Guo, Wei Liang, Ou Liu, Liteng Lin, Yugang Huang, Kangshun Zhu, Guodong Ye
Transcatheter arterial embolization plays a pivotal role in treating various diseases. However, the efficacy of embolization therapy in cancer treatment can be limited by several factors, such as inevitable incomplete or non-target embolization, and the tumor recurrence and metastasis caused by the hypoxic microenvironment. Moreover, it is essential to explore simpler, more economical, and efficient
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A multifunctional composite hydrogel that sequentially modulates the process of bone healing and guides the repair of bone defects Biomed. Mater. (IF 4.0) Pub Date : 2024-03-08 Kun Lu, Dongliang Wang, Guoyou Zou, Ya Wu, Feng Li, Qunshan Song, Yongming Sun
Calcium carbonate (CaCO3), which exhibits excellent biocompatibility and bioactivity, is a well-established bone filling material for bone defects. Here, we synthesized CaCO3 microspheres (CMs) to use as an intelligent carrier to load bone morphogenetic protein-2 (BMP-2). Subsequently, drug-loaded CMs and catalase (CAT) were added to methacrylated gelatin (GelMA) hydrogels to prepare a composite hydrogel
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Patterned collagen films loaded with miR-133b@MBG-NH2 for potential applications in corneal stromal injury repair Biomed. Mater. (IF 4.0) Pub Date : 2024-03-08 Guancheng Zhan, Lixia Yu, Qiqi Wang, Longyang Jin, Xiaohong Yin, Xiaodong Cao, Huichang Gao
Corneal stromal injury is a common surgical disease. With the development of tissue engineering materials, many artificial corneal scaffolds have been developed to replace allograft corneal transplantation and solve the problem of corneal donor shortage. However, few researchers have paid attention to corneal stromal wound healing. Herein, a nanocomposite of amino modified mesoporous bioactive glass
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Transparent injectable sericin-honey hydrogel with antioxidant and antibacterial activities combined with feeding sericin accelerates diabetic wound healing Biomed. Mater. (IF 4.0) Pub Date : 2024-03-08 Yongkang Wei, Yanwei Li, Yurong Li, Gang Xu, Tangfeng Wu, Xiang Li, Ruixi Ye, Meilin Xi, Xiaomei Li, Guozheng Zhang, Yeshun Zhang
Wound healing in diabetics is often impaired or delayed due to the presence of high reactive oxygen species and low antioxidant levels. Here, a sericin-honey semi-interpenetrating network hydrogel with excellent antioxidant activity was prepared. Besides, the sericin-honey hydrogel is transparent, injectable, sticky, highly porous, and has good swelling properties, antibacterial activity, and cell
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Nanoengineered oxygen-releasing polymeric scaffold with sustained release of dexamethasone for bone regeneration Biomed. Mater. (IF 4.0) Pub Date : 2024-03-07 Aatikaben Vahora, Hemant Singh, Aniruddha Dan, Surya Suresh Puthenpurackel, Narayan Chandra Mishra, Mukesh Dhanka
Maintaining the continuous oxygen supply and proper cell growth before blood vessel ingrowth at the bone defect site are considerably significant issues in bone regeneration. Oxygen-producing scaffolds can supply oxygen and avoid hypoxia leading to expedited bone regeneration. Herein, first oxygen-producing calcium peroxide nanoparticles (CPO NPs) are synthesized, and subsequently, the various amounts
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3D printed high-precision porous scaffolds prepared by fused deposition modeling induce macrophage polarization to promote bone regeneration Biomed. Mater. (IF 4.0) Pub Date : 2024-03-07 Xiangyu Wang, Xinyu Fu, Dongmei Luo, Ruxia Hou, Peiwen Li, Yurou Chen, Xinyao Zhang, Xiangjie Meng, Yingge Yue, Junyu Liu
Macrophage-mediated bone immune responses significantly influence the repair of bone defects when utilizing tissue-engineered scaffolds. Notably, the scaffolds’ physical structure critically impacts macrophage polarization. The optimal pore size for facilitating bone repair remains a topic of debate due to the imprecision of traditional methods in controlling scaffold pore dimensions and spatial architecture
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Nitroprusside and metal nitroprusside nano analogues for cancer therapy Biomed. Mater. (IF 4.0) Pub Date : 2024-03-06 Sanchita Tripathy, Swapnali Londhe, Chitta Ranjan Patra
Sodium nitroprusside (SNP), U.S approved drug has been used in clinical emergency as a hypertensive drug for more than a decade. It is well established for its various biomedical applications such as angiogenesis, wound healing, neurological disorders including anti-microbial applications etc. Apart from that, SNP have been considered as excellent biomedical materials for its use as anti-cancer agent
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Vanadocene-functionalized mesoporous silica nanoparticles: platforms for the development of theranostic materials against breast cancer Biomed. Mater. (IF 4.0) Pub Date : 2024-03-06 Michael Aondona Iorhemba, Javier Álvarez-Conde, Diana Díaz-García, José Manuel Méndez-Arriaga, Victoria García-Almodóvar, Karina Ovejero-Paredes, Sulaiman Ola Idris, Gideon Adamu Shallangwa, Ibrahim Abdulkadir, Sanjiv Prashar, Marco Filice, Santiago Gómez-Ruiz
Nanoscale materials have demonstrated a very high potential in anticancer therapy by properly adjusting their functionalization and physicochemical properties. Herein, we report the synthesis of some novel vanadocene-loaded silica-based nanomaterials incorporating four different S-containing amino acids (penicillamine, methionine, captopril, and cysteine) and different fluorophores (rhodamine B, coumarin
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Facile process of Hibiscus mucilage polymer formulation using Hibiscus rosa-sinensis leaves to treat second-degree burn and excision wounds Biomed. Mater. (IF 4.0) Pub Date : 2024-03-05 Ishita Saha, Sourav Ghosh, Shubham Roy, Tarakdas Basu, Parimal Karmakar
Mucilage is a sticky substance found in various plants and microorganisms and is made up of proteins and polysaccharides. Mucilage from Hibiscus rosa sinensisis is a complex polysaccharide traditionally used to treat different skin diseases. In our study, we fabricated mucilage polymer from Hibiscus rosa sinensis leaves and evaluated its potential application in second-degree burns and excision wounds
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Stimuli-triggered multilayer films in response to temperature and ionic strength changes for controlled favipiravir drug release Biomed. Mater. (IF 4.0) Pub Date : 2024-03-05 Li Xu, Lang He, Yinzhao Li, Tingwei Cai, Jianhua Zhang, Zihan Chu, Xiaochen Shen, Raymond Cai, Haifeng Shi, Chunyin Zhu
The block copolymer micelles and natural biopolymers were utilized to form layer-by-layer (LbL) films via electrostatic interaction, which were able to effectively load and controllably release favipiravir, a potential drug for the treatment of coronavirus epidemic. The LbL films demonstrated reversible swelling/shrinking behavior along with the manipulation of temperature, which could also maintain
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Mechanical fabrication and evaluation of bioresorbable barbed sutures with different barb geometries Biomed. Mater. (IF 4.0) Pub Date : 2024-03-04 Karuna Nambi Gowri, Martin W King
Bioresorbable polymeric sutures are gaining interest from surgeons and patients as they reduce surgical stress and trauma. This study involves two bioresorbable polymers, namely, catgut and poly(4-hyrdorxybutyrate) (P4HB) that are used widely in cosmetic procedures. P4HB barbed sutures are favorably used in rhytidectomy (micro-facelifts) procedures while catgut sutures are widely used for external
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Ecofriendly and scalable production of bioglass using an organic calcium source enhanced bioactivity for tissue repair Biomed. Mater. (IF 4.0) Pub Date : 2024-03-04 Yun Chen, Fang Hu, Chuangzhou Guo, Xihua Dong, Hai Wang, Yue Qin
The eco-friendly and scalable production of bioglass remains a challenging but attractive strategy for advancing its widespread biomedical applications. Although the sol–gel method has been considered a valuable approach for bioglass production, the application of calcium nitrate as a calcium source markedly limits its industrialization owing to environmental pollution, high administration costs, and
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Exploration of microstructural characteristics, mechanical properties, and in vitro biocompatibility of biodegradable porous magnesium scaffolds for orthopaedic implants Biomed. Mater. (IF 4.0) Pub Date : 2024-03-01 Debasish Debbarma, Nikhil Anand, Kaushik Pal
In this study, porous magnesium (Mg) scaffolds were investigated with varying strontium (Sr) and constant zinc (Zn) concentrations through the powder metallurgy process. All samples were examined at room temperature to evaluate their microstructure, mechanical and in-vitro degradation behaviour and biological properties. Results indicated that adding Sr was associated with fine average grain size,
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Methods to improve antibacterial properties of PEEK: A review Biomed. Mater. (IF 4.0) Pub Date : 2024-02-29 Idil Uysal, Ayşen Tezcaner, Zafer Evis
As a thermoplastic and bioinert polymer, polyether ether ketone (PEEK) serves as spine implants, femoral stems, cranial implants, and joint arthroplasty implants due to its mechanical properties resembling the cortical bone, chemical stability, and radiolucency. Although there are standards and antibiotic treatments for infection control during and after surgery, the infection risk is lowered but can
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Icariin regulates RANKL-induced osteoclast differentiation via the ERα/c-Src/RANK signaling Biomed. Mater. (IF 4.0) Pub Date : 2024-02-28 Shaolin Yang, Xiaocui Zhang, Xiaofei Liao, Yi Ding, Juwen Gan
Osteoporosis (OP) is a common metabolic bone disease. Excessive osteoclastic activity significantly contributes to the development of OP. Icariin (ICA) is a flavonol glycoside derived from herbal plants and possesses curative effects on postmenopausal OP and bone fracture. This study aimed to investigate the effects of ICA on osteoclast differentiation induced by receptor activator of nuclear factor
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A facile method to fabricate versatile keratin cryogels for tissue engineering applications Biomed. Mater. (IF 4.0) Pub Date : 2024-02-28 Zhitong Zhao, Huei Min Chua, Hui Ying Lai, Kee Woei Ng
Human hair keratin (HHK) has been extensively explored as a biomaterial for soft tissue regeneration due to their excellent bioactivity and biocompatibility. The possibility to fabricate HHK into three-dimensional (3D) hydrogels with physical properties resembling soft tissues has been well demonstrated. However, conventional keratin hydrogels often exhibit a dense architecture that could hinder cell
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Exploring the efficacy of tryptone-stabilized silver nanoparticles against respiratory tract infection-causing bacteria: a study on planktonic and biofilm forms Biomed. Mater. (IF 4.0) Pub Date : 2024-02-28 Pooja Pandey, Sristi Pradhan, Kimaya Meher, Manu Lopus, Sirisha L Vavilala
Respiratory tract infections (RTIs) are a common cause of mortality and morbidity in the human population. The overuse of antibiotics to overcome such infections has led to antibiotic resistance. The emergence of multidrug resistant bacteria is necessitating the development of novel therapeutic techniques in order to avoid a major global clinical threat. Our study aims to investigate the potential
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Semisolid extrusion 3D printing of Dolutegravir-Chitosan nanoparticles laden polymeric buccal films: personalized solution for pediatric treatment Biomed. Mater. (IF 4.0) Pub Date : 2024-02-27 Priya Dharshini Krishnan, Ramya Devi Durai, Sivanjineyulu Veluri, Vedha Hari B Narayanan
In this work, the semi solid extrusion 3D printing process was utilized to incorporate anti-HIV drug Dolutegravir and its nanoparticles into the buccal film (BF) that was fabricated using the developed polymer ink. The composite made of polyvinyl alcohol (PVA) and sodium alginate was processed into a 3D printing polymer ink with optimum viscosity (9587 ± 219 cP) needed for the seamless extrusion through
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Drug release control and anti-inflammatory effect of biodegradable polymer surface modified by gas phase chemical functional reaction Biomed. Mater. (IF 4.0) Pub Date : 2024-02-26 Inho Bae, Byung-Hoon Kim
The plasma technique has been widely used to modify the surfaces of materials. The purpose of this study was to evaluate the probability of controlling the prednisolone delivery velocity on a polylactic acid (PLA) surface modified by plasma surface treatment. Surface modification of PLA was performed at a low-pressure radio frequency under conditions of 100 W power, 50 mTorr chamber pressure, 100–200
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Facile cost-effective green synthesis of carbon dots: selective detection of biologically relevant metal ions and synergetic efficiency for treatment of cancer Biomed. Mater. (IF 4.0) Pub Date : 2024-02-26 Somedutta Maity, Monami Das Modak, Munendra Singh Tomar, Kirti Wasnik, Prem Shankar Gupta, Sukanya Patra, Divya Pareek, Monika Singh, Monica Pandey, Pradip Paik
A facile cost-effective green synthesis approach has been used to synthesize carbon-dot (CDs) from the Kernel part of the Azadirachta Indica seeds and investigated their fluorescent and metal ions sensing capability and also used for the delivery of drugs. Metallic ions such as Ca2+, K+, Na+, Fe3+, and Zn2+ which are biologically important for many reactions and are selectively detected through the
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The effect of Wharton’s jelly-derived stem cells seeded/boron-loaded acellular scaffolds on the healing of full-thickness burn wounds in the rat model Biomed. Mater. (IF 4.0) Pub Date : 2024-02-26 Sadeneh Nikzad, Saeideh Same, Saeid Safiri, Sanam Dolati, Babak Roushangar Zineh, Shahla Meshgi, Leila Roshangar, Fikrettin Şahin
Burn wounds are the most destructive and complicated type of skin or underlying soft tissue injury that are exacerbated by a prolonged inflammatory response. Several cell-based therapeutic systems through the culturing of potent stem cells on modified scaffolds have been developed to direct the burn healing challenges. In this context, a new regenerative platform based on boron (B) enriched-acellular
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Electrospun zein nanofibers loaded with curcumin as a wound dressing: enhancing properties with PSS and PDADMAC layers Biomed. Mater. (IF 4.0) Pub Date : 2024-02-26 Nasrin Salehi, Azadeh Ghaee, Hanieh Moris, Sara Derhambakhsh, Mehdi Mansour Sharifloo, Farzaneh Safshekan
Development of wound dressings with enhanced therapeutic properties is of great interest in the modern healthcare. In this study, a zein-based nanofibrous wound dressing containing curcumin as a therapeutic agent was fabricated through electrospinning technique. In order to achieve desirable properties, such as antibacterial characteristics, reduced contact angle, and enhanced mechanical properties
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Current approaches in tissue engineering-based nanotherapeutics for osteosarcoma treatment Biomed. Mater. (IF 4.0) Pub Date : 2024-02-26 Abinaya Shanmugavadivu, Sundaravadhanan Lekhavadhani, P J Miranda, Nagarajan Selvamurugan
Osteosarcoma (OS) is a malignant bone neoplasm plagued by poor prognosis. Major treatment strategies include chemotherapy, radiotherapy, and surgery. Chemotherapy to treat OS has severe adverse effects due to systemic toxicity to healthy cells. A possible way to overcome the limitation is to utilize nanotechnology. Nanotherapeutics is an emerging approach in treating OS using nanoparticulate drug delivery
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The development of an in vitro human hair follicle organoid with a complexity similar to that in vivo Biomed. Mater. (IF 4.0) Pub Date : 2024-02-23 Paulo André Marinho, Gyusang Jeong, Seung Hyun Shin, Su Na Kim, Hyeongwon Choi, Sung Hoon Lee, Byung Cheol Park, Yong Deog Hong, Hyoung-June Kim, Won-Seok Park
In vitro hair follicle (HF) models are currently limited to ex vivo HF organ cultures (HFOCs) or 2D models that are of low availability and do not reproduce the architecture or behavior of the hair, leading to poor screening systems. To resolve this issue, we developed a technology for the construction of a human in vitro hair construct based on the assemblage of different types of cells present in
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An in vitro three-dimensional (3D) testicular organoid culture system for efficient gonocyte maintenance and propagation using frozen/thawed neonatal bovine testicular tissues Biomed. Mater. (IF 4.0) Pub Date : 2024-02-20 Shiyan Tang, Celine Jones, Rajwa Mecca, Jill Davies, Sheila Lane, Kevin Coward
Fertility preservation in prepubertal boys with cancer requires the cryopreservation of immature testicular tissues (ITTs) prior to gonadotoxic treatment. However, the limited number of germ cells in small human ITT biopsies necessitates the development of an in vitro culture system for germ cell expansion using frozen-thawed ITTs. Here, we generated testicular organoids for the in vitro maintenance
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Devitrite (Na2Ca3Si6O16) phase dominated nanostructured 45S5 bioactive glass: exploring its structural and biological properties Biomed. Mater. (IF 4.0) Pub Date : 2024-02-16 K Elakkiya, C Ashok Raja, S Balakumar
This research study is primarily centred around calcination temperature and time influence on phase formation in bioactive glasses (BGs). In the present study, BG with a nominal composition of 45S5 was synthesized through the sol–gel process. The developed BGs then underwent heat treatment for various sintering durations and temperatures. X-ray diffraction (XRD) patterns of the BGs reveals that the
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Bioactive gelatin-sheets as novel biopapers to support prevascularization organized by laser-assisted bioprinting for bone tissue engineering Biomed. Mater. (IF 4.0) Pub Date : 2024-02-16 Olivia Kérourédan, Ayako Washio, Charles Handschin, Raphaël Devillard, Shoichiro Kokabu, Chiaki Kitamura, Yasuhiko Tabata
Despite significant advances in the management of patients with oral cancer, maxillofacial reconstruction after ablative surgery remains a clinical challenge. In bone tissue engineering, biofabrication strategies have been proposed as promising alternatives to solve issues associated with current therapies and to produce bone substitutes that mimic both the structure and function of native bone. Among
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Steroid hormone receptor based gene delivery systems as potential oral cancer therapeutics Biomed. Mater. (IF 4.0) Pub Date : 2024-02-15 Dwaipayan Bhattacharya, Madhu Rani Bharati, Kalyani Sakhare, Piyush Khandelia, Rajkumar Banerjee, Kumar Pranav Narayan
Glucocorticoid and Mineralocorticoid receptors are principally ligand-dependent intracellular transcription factors that are known to influence the development and growth of many human cancers. Our study investigates the potential of these receptors to act as a target for oral cancer treatment since findings in this regard are sparse till date. Leveraging the aberrant behavior of steroid hormone receptors
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The role of decellularized cell derived extracellular matrix in the establishment and culture of in vitro breast cancer tumor model Biomed. Mater. (IF 4.0) Pub Date : 2024-02-15 Atakan Tevlek
Decades of research have shown that two-dimensional cell culture studies are insufficient for preclinical cancer diagnosis and treatment, and that cancer cells in three-dimensional (3D) culture systems have better cell–cell and cell–matrix interactions, gene expression, heterogeneity, and structural complexity that more closely resemble in vivo tumors. Researchers are still optimizing 3D culturing
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Micromechanics of fibrous scaffolds and their stiffness sensing by cells Biomed. Mater. (IF 4.0) Pub Date : 2024-02-14 Dhruba Jyoti Mech, Mohd Suhail Rizvi
Mechanical properties of the tissue engineering scaffolds are known to play a crucial role in cell response. Therefore, an understanding of the cell-scaffold interactions is of high importance. Here, we have utilized discrete fiber network model to quantitatively study the micromechanics of fibrous scaffolds with different fiber arrangements and cross-linking densities. We observe that localized forces
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Organic-inorganic biohybrid films from wool-keratin/jellyfish-collagen/silica/boron via sol-gel reactions for soft tissue engineering applications Biomed. Mater. (IF 4.0) Pub Date : 2024-02-13 Safiye Nur Yildiz, Tugba Sezgin Arslan, Yavuz Emre Arslan
Therapeutic angiogenesis is pivotal in creating effective tissue-engineered constructs that deliver nutrients and oxygen to surrounding cells. Hence, biomaterials that promote angiogenesis can enhance the efficacy of various medical treatments, encompassing tissue engineering, wound healing, and drug delivery systems. Considering these, we propose a rapid method for producing composite silicon-boron-wool
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Braided biomimetic PCL grafts for anterior cruciate ligament repair and regeneration Biomed. Mater. (IF 4.0) Pub Date : 2024-02-13 Sanazar Kadyr, Ulpan Nurmanova, Bakhytbol Khumyrzakh, Aida Zhakypbekova, Dina Saginova, Nurgul Daniyeva, Cevat Erisken
Anterior cruciate ligament (ACL) is a knee joint stabilizer with a limited regeneration capacity mainly because of low cellular content. State-of-the-art procedures are unable to restore the functions of the tissue as demonstrated by limited success rates. Regenerative engineering can offer a solution for restoring the functions of torn/ruptured ligaments provided that biomimetic grafts are available
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Advantages and limitations of using cell viability assays for 3D bioprinted constructs Biomed. Mater. (IF 4.0) Pub Date : 2024-02-13 Sofia Avnet, Gemma Di Pompo, Giorgia Borciani, Tiziana Fischetti, Gabriela Graziani, Nicola Baldini
Bioprinting shows promise for bioengineered scaffolds and three-dimensional (3D) disease models, but assessing the viability of embedded cells is challenging. Conventional assays are limited by the technical problems that derive from using multi-layered bioink matrices dispersing cells in three dimensions. In this study, we tested bioprinted osteogenic bioinks as a model system. Alginate- or gelatin-based