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Comparative structural and immunological analysis of outer membrane proteins and dermonecrotic toxin in Bordetella bronchiseptica canine isolate Vet. Immunol. Immunopathol. (IF 1.8) Pub Date : 2024-04-20 Ji Young Jang, Myung Whan Oh, Chaeyeong Na, Young Bin Im, Soojin Shim, Hyoung Joon Moon, Han Sang Yoo
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Identification of differentially expressed genes and metabolism signaling pathway in the spleen of broilers supplemented with probiotic Bacillus spp. Vet. Immunol. Immunopathol. (IF 1.8) Pub Date : 2024-04-18 Anh Duc Truong, Ha Thi Thanh Tran, Huyen Thi Nguyen, Nhu Thi Chu, Lanh Phan, Hoai Thi Phan, Ngoc Thi Pham, Van Hai Nguyen, Lan Huong Nguyen, Dang Kim Pham, Phu- Ha Ho, Hoang Vu Dang
Probiotics are essential in the body’s nutrients, improving the ratio of meat to meat, immune response, and preventing diseases. In this study, RNA-sequencing (RNA-seq) was used to identify the differentially expressed genes (DEGs), enriched related pathways, and Gene Ontology (GO) terms among blank negative control (NC), supplemented with spp. (BS) and commercial probiotic (PC) groups after a 42-day
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An isotonic protein solution favorably modulated the porcine intestinal immune response and cellular adhesion markers and reduced PEDV shedding in vivo Vet. Immunol. Immunopathol. (IF 1.8) Pub Date : 2024-04-06 Dmytro M. Masiuk, Andrii V. Kokariev, Stefan G. Buzoianu, Ava M. Firth, Victor S. Nedzvetsky
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Computational antigenic insights into the novel NADC-34-like Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) isolate YC-2020 Vet. Immunol. Immunopathol. (IF 1.8) Pub Date : 2024-04-04 Maria Karolaynne da Silva, Jonas Galileu Ferreira de Aquino, Claudio Bruno Silva de Oliveira, João Firmino Rodrigues-Neto, Miadur Rahman, Shahina Akter, Umberto Laino Fulco, Yousef A. Bin Jardan, Samir Ibenmoussa, Jonas Ivan Nobre Oliveira
In this computational study, we advanced the understanding of the antigenic properties of the NADC-34-like isolate of the Porcine Reproductive and Respiratory Syndrome Virus (PRRSV), named YC-2020, relevant in veterinary pathology. We utilized sequence comparison analyses of the M and N proteins, comparing them with those of NADC34, identifying substantial amino acid homology that allowed us to highlight
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Zymosan and lipopolysaccharide decrease gene expression of neuronal nitric oxide synthase in peripheral organs in chicks Vet. Immunol. Immunopathol. (IF 1.8) Pub Date : 2024-04-02 Maki Takahashi, Tomohisa Ishida, Sakirul Khan, Ryosuke Makino, Mark A. Cline, Tetsuya Tachibana
Nitric oxide (NO) is gaseous bioactive molecule that is synthesized by NO synthase (NOS). Inducible NOS (iNOS) expression occurs in response to pathogenic challenges, resulting in the production of large amounts of NO. However, there is a lack of knowledge regarding neuronal NOS (nNOS) and endothelial NOS (eNOS) in birds during pathogenic challenge. Therefore, the present study was conducted to determine
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Monophosphoryl lipid A and poly I:C combination enhances immune responses of equine influenza virus vaccine Vet. Immunol. Immunopathol. (IF 1.8) Pub Date : 2024-03-18 Dong-Ha Lee, Jueun Lee, So Yeon Ahn, Thi Len Ho, Kiyeon Kim, Eun-Ju Ko
Equine influenza is a contagious respiratory disease caused by H3N8 type A influenza virus. Vaccination against equine influenza is conducted regularly; however, infection still occurs globally because of the short immunity duration and suboptimal efficacy of current vaccines. Hence the objective of this study was to investigate whether an adjuvant combination can improve immune responses to equine
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The effects of Bacillus subtilis on the immunity, mucosal tissue morphology, immune-related gene transcriptions, and intestinal microbiota in flounder (Paralichthys olivaceus) with two feeding methods: Continuous versus discontinuous feeding Vet. Immunol. Immunopathol. (IF 1.8) Pub Date : 2024-03-17 Yingli Gao, Ruiming Tan, Zicheng Wang, Lu Qiang, Haijing Yao
Probiotics as dietary additives can improve weight gain, feed efficiency, and disease resistance in cultured fish. In this research, we evaluated and compared the effects of on immunity, mucosal tissue morphology, immune-related gene transcriptions, and intestinal microbiota in flounder () by a 30-day feeding experiment based on a continuous feeding schedule (E1) and a discontinuous feeding schedule
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Quantification of CD3, FoxP3, and granzyme B immunostaining in canine renal cell carcinoma Vet. Immunol. Immunopathol. (IF 1.8) Pub Date : 2024-03-16 Ashleigh Cournoyer, Hayley Amerman, Charles-Antoine Assenmacher, Amy Durham, James A. Perry, Allison Gedney, Nicholas Keuler, Matthew J. Atherton, Jennifer A. Lenz
Tumor-infiltrating lymphocyte (TIL) density plays an important role in anti-tumor immunity and is associated with patient outcome in various human and canine malignancies. As a first assessment of the immune landscape of the tumor microenvironment in canine renal cell carcinoma (RCC), we retrospectively analyzed clinical data and quantified CD3, FoxP3, and granzyme B immunostaining in formalin-fixed
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Evaluation of Ki-67, goblet cell and MUC2 mucin RNA expression in dogs with lymphoplasmacytic and granulomatous colitis Vet. Immunol. Immunopathol. (IF 1.8) Pub Date : 2024-03-16 Chelsea Lim, Julien R.S. Dandrieux, Richard Ploeg, Cameron J. Nowell, Simon M. Firestone, Caroline S. Mansfield
Intestinal mucus barrier disruption may occur with chronic inflammatory enteropathies. The lack of studies evaluating mucus health in dogs with chronic colitis arises from inherent challenges with assessment of the intestinal mucus layer. It is therefore unknown if reduced goblet cell (GBC) numbers and/or mucin 2 (MUC2) expression, which are responsible for mucus production and secretion, correlate
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Immunophenotyping of canine T cell activation and proliferation by combined protein and RNA flow cytometry Vet. Immunol. Immunopathol. (IF 1.8) Pub Date : 2024-02-28 Xu Zhu, Kara Rogers, Christine Bono, Zhenyu Wang, Carol Donovan, Changhua Ji
The limited availability of canine-reactive monoclonal antibodies restricts the analyses of immune cell subsets and their functions by flow cytometry. The PrimeFlow™ RNA Assay may serve as a potential solution to close this gap. Here we report a blood immunophenotyping method utilizing combined protein- and RNA-based flow cytometry to characterize canine T cell activation and proliferation within individual
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Progress in the development and use of monoclonal antibodies to study the evolution and function of the immune systems in the extant lineages of ungulates Vet. Immunol. Immunopathol. (IF 1.8) Pub Date : 2024-02-23 William C. Davis, Asmaa H. Mahmoud, Victoria Hulubei, Amany Hasan, Gaber S. Abdellrazeq
Details on the origin and function of the immune system are beginning to emerge from genomic studies tracing the origin of B and T cells and the major histocompatibility complex. This is being accomplished through identification of DNA sequences of ancestral genes present in the genomes of lineages of vertebrates that have evolved from a common primordial ancestor. Information on the evolution of the
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Neutrophil extracellular traps and active myeloperoxidase concentrate in lamellar tissue of equids with naturally occurring laminitis Vet. Immunol. Immunopathol. (IF 1.8) Pub Date : 2024-02-23 Nazaré Storms, Geoffroy de la Rebière, Thierry Franck, Ange Mouithys Mickalad, Charlotte Sandersen, Justine Ceusters, Didier Serteyn
Laminitis is a pathology of the equine digit ultimately leading to a failure of the dermo-epidermal interface. Neutrophil activation is recognized as a major factor in SIRS-associated laminitis and has recently been described in induced endocrinopathic laminitis evidenced by the presence of myeloperoxidase (MPO). Neutrophil extracellular traps (NET) are released with neutrophil activation. This study
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Design and development of multiepitope chimeric antigens by bioinformatic and bacterial based recombinant expression methods, with potential application for bovine tuberculosis serodiagnosis Vet. Immunol. Immunopathol. (IF 1.8) Pub Date : 2024-02-13 Cassiano Martin Batista, Josir Laine Veschi, Vanessa Felipe de Souza, Leonardo Foti, Lea Chapaval Andri
Bovine tuberculosis (bTB), which is caused by is a single health concern, which causes economic losses, is a sanitary barrier and is a zoonotic concern. The golden-pattern intradermic tests have low sensitivity of about 50%. To fix this sensitivity problem, immunoassays could be a powerful tool. However, few studies produced antigens for bTB immunoassays, which needs improvements. Aim of this study
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Canine T zone lymphoma is a tumor of mature, previously activated αβ T cells Vet. Immunol. Immunopathol. (IF 1.8) Pub Date : 2024-02-07 Kelly Hughes, Evan Conaway, Emily Blackwell, Emily Rout, Janna Yoshimoto, Robert Burnett, Anne Avery
T cell lymphomas are a diverse group of tumors found in both dogs and humans, originating from various normal T cell types. Identifying the origin of neoplastic lymphocytes can offer valuable insights into the pathogenesis and clinical behavior of these tumors. T zone lymphoma (TZL) in dogs is characterized by the absence of CD45 expression, a strong breed predilection, and its association with adult-onset
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Immunophenotyping of peripheral circulating lymphocytes and serum selenium levels in calves with neonatal diarrhea Vet. Immunol. Immunopathol. (IF 1.8) Pub Date : 2024-02-06 Murat Uztimür, Ömer Kizil, Hatice Handan Akbulut
This work aims to: (1) elucidate the immune response exhibited by CD4+ and CD8+ T lymphocyte cells in response to various infectious agents in calves suffering with neonatal diarrhea; and (2) determine and investigate the association between serum selenium levels and T lymphocyte subtypes in neonatal calves afflicted with neonatal diarrhea and infected with various infectious agents. The study encompassed
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Immunomodulatory effect of Lacticaseibacillus casei CB054 supplementation in calves vaccinated against infectious bovine rhinotracheitis Vet. Immunol. Immunopathol. (IF 1.8) Pub Date : 2024-02-02 Carolina Litchina Brasil, Vitória Sequeira Gonçalves, Francisco Denis Souza Santos, Paulo Ricardo Centeno Rodrigues, Fábio Pereira Leivas Leite, Daniela Isabel Brayer Pereira
Probiotics are live microorganisms that, confer health benefits to the host when supplemented in adequate amounts. They can promote immunomodulation by inducing phagocyte activity, leukocyte proliferation, antibody production, and cytokine expression. Lactic acid bacteria (BAL) are important probiotic specimens with properties that can improves ruminant nutrition, productivity and immunity. The aim
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Potential to use cannabinoids as adjunct therapy for dexamethasone: An in vitro study with canine peripheral blood mononuclear cells Vet. Immunol. Immunopathol. (IF 1.8) Pub Date : 2024-02-01 Sabrina Dixon, Arpita Deb, Todd Archer, Barbara L.F. Kaplan
Dexamethasone (dex) is a potent glucocorticoid used to treat a variety of diseases. It is widely used in veterinary medicine in many species; for instance, in dogs, it can be used for emergent cases of anaphylaxis or trauma, management of immune-mediated hemolytic anemia or thrombocytopenia, certain cancers, allergic reactions, and topically for skin or eye inflammation. Dex is not without its side
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Serological monitoring of Enterococcus cecorum specific antibodies in chickens Vet. Immunol. Immunopathol. (IF 1.8) Pub Date : 2024-01-22 Amanda Silberborth, Jana Schnug, Silke Rautenschlein, Arne Jung
Pathogenic Enterococcus cecorum (EC) has gained increasing importance as the cause of skeletal infections in meat-type chicken production. Since effective intervention strategies are scarce, it must be focused on preventive measures. Vaccination of meat-type breeder chicken flocks is common practice to protect the progeny against infection with EC. However, no data are available on seroconversion after
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Characterization of immune responses and immunopathology in turkeys experimentally infected with clostridial dermatitis-producing strains of Clostridium septicum Vet. Immunol. Immunopathol. (IF 1.8) Pub Date : 2024-01-24 Valeria Criollo, Feba Ann John, Carissa Gaghan, Oscar J Fletcher, Anil Thachil, Rocio Crespo, Raveendra. R. Kulkarni
Clostridium septicum is one of the major causative agents of clostridial dermatitis (CD), an emerging disease of turkeys, characterized by sudden deaths and necrotic dermatitis. Despite its economic burden on the poultry industry, the immunopathological changes and pathogen-specific immune responses are poorly characterized. Here, we used three strains of C. septicum, namely Str. A1, Str. B1 and Str
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Myeloid derived suppressor cells in peripheral blood can be a prognostic factor in canine transitional cell carcinoma Vet. Immunol. Immunopathol. (IF 1.8) Pub Date : 2024-01-20 Shohei Yokota, Tomohiro Yonezawa, Yasuyuki Momoi, Shingo Maeda
Myeloid-derived suppressor cells (MDSCs) are immature cells with immunosuppressive properties found in the tumor microenvironment. MDSCs are divided into two major subsets: polymorphonuclear MDSCs (PMN-MDSCs) and monocytic MDSCs (M-MDSCs). Both MDSC subsets contribute to the creation of an immunosuppressive environment for tumor progression. In humans, patients with high levels of MDSCs show worse
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Efficacy of an inactivated influenza vaccine adjuvanted with Toll-like receptor ligands against transmission of H9N2 avian influenza virus in chickens Vet. Immunol. Immunopathol. (IF 1.8) Pub Date : 2024-01-11 Sugandha Raj, Mohammadali Alizadeh, Ayumi Matsuyama-Kato, Nitish Boodhoo, Myles St Denis, Éva Nagy, Samira Mubareka, Khalil Karimi, Shahriar Behboudi, Shayan Sharif
Avian influenza viruses (AIV), including the H9N2 subtype, pose a major threat to the poultry industry as well as to human health. Although vaccination provides a protective control measure, its effect on transmission remains uncertain in chickens. The objective of the present study was to investigate the efficacy of beta-propiolactone (BPL) whole inactivated H9N2 virus (WIV) vaccine either alone or
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The impact of age on vitamin D receptor expression, vitamin D metabolism and cytokine production in ex vivo Rhodococcus equi infection of equine alveolar macrophages Vet. Immunol. Immunopathol. (IF 1.8) Pub Date : 2024-01-02 LJ. Berghaus, J. Cathcart, RD. Berghaus, C. Ryan, RE. Toribio, KA. Hart
Rhodococcus equi (R. equi), a pneumonia-causing intracellular bacterium, results in significant morbidity and mortality in young foals, while healthy adult horses rarely develop disease. Survival and replication within alveolar macrophages (AMφ) are the hallmarks of R. equi’s pathogenicity. The vitamin D receptor (VDR) and its ligand, the active vitamin D metabolite 1,25(OH)2D, are important in immune
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Impact of apitherapy on canine, equine, and chicken lymphocytes, in vitro Vet. Immunol. Immunopathol. (IF 1.8) Pub Date : 2024-01-04 Jeffrey T. Turn, Joerg Mayer, Koichi Nagata, Frane Banovic, Kristina Meichner, David J. Hurley, Eric Koslowski, Robert M. Gogal Jr.
Apitherapy is a form of alternative medicine that utilizes products from the western honeybee (Apis mellifera), including honey, propolis, and honeybee venom, to improve the health status of human patients by altering host immunity. An added benefit of these products is that they are nutraceuticals and relatively inexpensive to aquire. Currently, little is known about the use of honeybee products in
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Insulin-like growth factor-1 expression levels in pro-inflammatory response in calves with neonatal systemic inflammatory response syndrome Vet. Immunol. Immunopathol. (IF 1.8) Pub Date : 2023-12-27 Kerim Emre Yanar, Cihan Gür, Şükrü Değirmençay, Ömer Aydın, Mustafa Sinan Aktaş, Sümeyye Baysal
The objective of this study was to investigate the mRNA expression of insulin-like growth factor-1 (IGF-1), pro-inflammatory cytokines (IL-1β, IL-6, IL-18, and TNF-α), serum immunoglobulin profiles (IgG and IgM), and lipid peroxidation status (MDA) in relation to pro-inflammatory cytokines. A case-controlled, prospective, and observational investigation was completed on 85 calves. Total RNA was isolated
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Expression and functional characterization of bovine receptor activator of NF-κB ligand (RANKL) Vet. Immunol. Immunopathol. (IF 1.8) Pub Date : 2023-12-21 Ambre F. Chapuis, Omar A. Alfituri, Jayne C. Hope, Jo Stevens, Jo Moore, Kevin Mclean, Dorota Androscuk, Inga Dry
Receptor activator of nuclear factor Kappa-B Ligand (RANKL) is a member of the tumor necrosis factor ligand (TNF) family involved in immune responses and immunomodulation. Expressed in various cells types around the body, RANKL plays a crucial role in bone remodeling and development of the thymus, lymph nodes and mammary glands. Research in other species demonstrates that RANKL is required for the
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Corrigendum to “Noticeable immune dysregulation-and-suppression in parvovirus affected dogs” [Vet. Immunol. Immunopathol., 265 (2023) 110663] Vet. Immunol. Immunopathol. (IF 1.8) Pub Date : 2023-12-14 Milad Shahbazi Asil, Niloofar Zarifian, Amirhossein Valafar, Darioush Shirani, Jalil Mehrzad
Abstract not available
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Altered apoptosis and proliferation in milk cells and PBMc from BLV-infected bovines with different proviral loads: Possible role of the BCL-2 family proteins, TNF-alpha, and receptors Vet. Immunol. Immunopathol. (IF 1.8) Pub Date : 2023-12-14 M.E. Ladera Gómez, M.V. Nieto Farias, M. Rodríguez, A. Váter, M.C. Ceriani, G.L. Dolcini
Bovines infected by bovine leukemia virus (BLV) are characterized by presenting low proviral load (LPL) or high proviral load (HPL). It is reported that animals with HPL in peripheral blood mononuclear cells (PBMCs) present a decrease in apoptosis, an increase in viability and the proliferation rate, while animals that maintain an LPL have an intrinsic ability to control the infection, presenting an
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The effect of doxycycline on canine neutrophil functions Vet. Immunol. Immunopathol. (IF 1.8) Pub Date : 2023-12-13 Johanna C. Rieder, Nicole Steffensen, Rabea Imker, Simon Lassnig, Nicole de Buhr
Doxycycline is a broad-spectrum tetracycline-class antibiotic that is frequently used to treat bacterial infections. Its use has also been described in immune-mediated diseases due to its immunomodulatory properties. The aim of this study was to evaluate the immunomodulatory effect of doxycycline on canine neutrophil functions. Therefore, the release of reactive oxygen species (ROS) and the formation
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Development of a next-generation sequencing protocol for the canine T cell receptor beta chain repertoire Vet. Immunol. Immunopathol. (IF 1.8) Pub Date : 2023-12-12 Cindy L. Zuleger, Rene Welch Schwartz, Irene M. Ong, Michael A. Newton, David M. Vail, Mark R. Albertini
Profiling the T cell receptor (TCR) repertoire using next-generation sequencing has become common in both human and translational research. Companion dogs with spontaneous tumors, including canine melanoma, share several features, e.g., natural occurrence, shared environmental exposures, natural outbred population, and immunocompetence. T cells play an important role in the adaptive immune system by
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Design of a randomized, placebo-controlled study evaluating efficacy and safety of a cancer preventative vaccine in dogs Vet. Immunol. Immunopathol. (IF 1.8) Pub Date : 2023-11-29 Jenna H. Burton, Stephen Albert Johnston, David M. Vail, Jens C. Eickhoff, Kathryn F. Sykes, Justin R. Brown, Luhui Shen, Ana Gervassi, Rodney L. Page, Jennifer L. Willcox, Sami Al-Nadaf, Amanda L. Willis, Danielle Biggs, Jessica Ralston, Irene Mok, Ilene D. Kurzman, Michael K. Huelsmeyer, Rubi Hayim, Brittany M. Smith, Douglas H. Thamm
Preventative anti-cancer vaccination strategies have long been hampered by the challenge of targeting the diverse array of potential tumor antigens, with successes to date limited to cancers with viral etiologies. Identification and vaccination against frameshift neoantigens conserved across multiple species and tumor histologies is a potential cancer preventative strategy currently being investigated
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Role of DLA-DRB1 amino acids outside the shared epitope in dachshund susceptibility to immune-mediated polyarthritis Vet. Immunol. Immunopathol. (IF 1.8) Pub Date : 2023-11-28 Meg Nakazawa, Ryuichi Nakajima, Ayaka Oshima, Atsushi Yamazaki, Masaharu Okano, Jiro Miyamae, Fumihiko Katakura, Kazuya Edamura, Tadaaki Moritomo, Toshihiro Watari
Canine immune-mediated polyarthritis (IMPA) is an idiopathic disorder encompassing both erosive and non-erosive forms of rheumatoid arthritis (RA), with a clinical picture similar to human RA. Resemblance in major histocompatibility complex (MHC)-associated risk between the two was first noted within the specific amino acid motif known as the shared epitope (SE) on human leukocyte antigen DRB1. Following
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SARS-CoV-2 seroprevalence determination in pets and camels in Egypt using multispecies enzyme-linked immunosorbent assay Vet. Immunol. Immunopathol. (IF 1.8) Pub Date : 2023-11-27 Hanaa Ahmed-Hassan, Manar M. Farouk, M.E. Ali, Esraa A. Elsafiee, Naglaa Hagag, Fatma Abdelkader
The coronavirus disease 2019 (COVID-19) pandemic has translated into a worldwide economic recession and public health crisis. Bats have been incriminated as the main natural host for the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which is the causative agent of the COVID-19 pandemic. However, the reservoir and carrier hosts of the virus remain unknown. Therefore, a cross sectional
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Topics on maternal, fetal and neonatal immunology of dogs and cats Vet. Immunol. Immunopathol. (IF 1.8) Pub Date : 2023-11-21 Keylla Helena Nobre Pacífico Pereira, Kárita da Mata Fuchs, Júlia Cosenza Mendonça, Gleice Mendes Xavier, Fabíola Cardoso Knupp, Maria Lucia Gomes Lourenço
Birth and the first few weeks of age are critical periods of developing the immune system of puppies and kittens and adapting to an environment containing a variety of infectious agents. The survival rate during these periods depends mainly on the newborn's immune capacity to prevent and combat infections. Although most components of innate and adaptive immunity are present at birth, responses are
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Bovine NK subsets in the afferent lymph and lymph nodes have distinct expression of naïve and activation-associated cell surface expressed molecules, and are differentially stimulated by BCG vaccination Vet. Immunol. Immunopathol. (IF 1.8) Pub Date : 2023-11-19 Andrew J. Hanton, Lindsey A. Waddell, Jayne C. Hope, Mark Gray, Zhiguang Wu
Bovine natural killer (bNK) cells are heterogeneous cell populations defined by constitutive expression of the natural cytotoxicity receptor, NKp46 (CD335). Two major subsets of bNK cells, classified by differential expression of CD2, display divergent functions in innate immunity, and are hypothesised to contribute to adaptive immunity following vaccination. Here we characterised phenotypic variation
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A novel monoclonal antibody against porcine macrophage colony-stimulating factor (CSF1) detects expression on the cell surface of macrophages Vet. Immunol. Immunopathol. (IF 1.8) Pub Date : 2023-11-18 Lindsey A. Waddell, Zhiguang Wu, Kristin A. Sauter, Jayne C. Hope, David A. Hume
Macrophage colony-stimulating factor (CSF1) controls the proliferation and differentiation of cells of the mononuclear phagocyte system through binding to the receptor CSF1R. The expression and function of CSF1 has been well-studied in rodents and humans, but knowledge is lacking in other veterinary species. The development of a novel mouse anti-porcine CSF1 monoclonal antibody (mAb) facilitates the
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Intramammary calcitriol treatment of mastitis alters profile of milk somatic cells and indicators of redox activity in milk Vet. Immunol. Immunopathol. (IF 1.8) Pub Date : 2023-11-18 Teri L. Wells, Michael B. Poindexter, Mercedes F. Kweh, Jeff Gandy, Corwin D. Nelson
The objective of this experiment was to determine the effect of intramammary calcitriol treatment on indicators of inflammation during an intramammary bacterial infection. Lactating Holstein cows were challenged with intramammary Streptococcus uberis. At the onset of mild or moderate mastitis, cows were randomly assigned to receive 10 µg of intramammary calcitriol (CAL, n = 7) or placebo control (CON;
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Prognostic potential of inflammatory markers, oxidative status, thrombocyte indices, and renal biochemical markers in neonatal calf diarrhoea-induced systemic inflammatory response syndrome Vet. Immunol. Immunopathol. (IF 1.8) Pub Date : 2023-11-13 Kerim Emre Yanar, Emre Eren, Mustafa Sinan Aktaş, Muhammed Sertaç Eroğlu, Özge Kandemir, Gürsel Aydın
The study aimed to assess the prognostic value of inflammatory markers, indicators of oxidative stress, thrombocyte indices, and renal biochemical markers in neonatal calf diarrhoea (NCD) induced by systemic inflammatory response syndrome (SIRS) upon admission. A prospective, observational, and case-control study was conducted on 56 calves diagnosed with NCD. Mean concentrations of interleukin-6 (IL-6)
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Association between major histocompatibility complex haplotypes and susceptibility of unvaccinated and vaccinated cattle to paratuberculosis Vet. Immunol. Immunopathol. (IF 1.8) Pub Date : 2023-11-07 Anabel A. Garcia, Karren M. Plain, Peter C. Thomson, Aaron J. Thomas, Christopher J. Davies, Jenny-Ann L.M.L. Toribio, Richard J. Whittington
Bovine Johne’s disease (BJD) or paratuberculosis is caused by Mycobacterium avium spp. paratuberculosis (MAP) and is a worldwide problem among domestic and wild ruminants. While vaccines are available, natural differences in background immunity between breeds within species and between individuals within herds suggest that genetic differences may be able to be exploited in marker-assisted selection
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Noticeable immune dysregulation-and-suppression in parvovirus affected dogs Vet. Immunol. Immunopathol. (IF 1.8) Pub Date : 2023-11-03 Milad Shahbazi Asil, Niloofar Zarifian, Amirhossein Valafar, Darioush Shirani, Jalil Mehrzad
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Role of Cherry Valley duck IRF1 mediated signal pathway in host anti-duck Tembusu virus Vet. Immunol. Immunopathol. (IF 1.8) Pub Date : 2023-11-04 Xingdong Song, Tingting Zhang, Bin Xing, Jinchao Wang, Xinyu Zhai, Xiuyuan Wang, Runchun Miao, Tianxu Li, Liangmeng Wei
China is the country with the largest amount of duck breeding as well as duck meat and egg production. In recent years, the emergence and spread of duck Tembusu virus (DTMUV) has become one of the important factors in reducing the amount of duck slaughter, which seriously endangers the duck breeding industry in our country. In-depth research on the mechanism of duck innate immunity facilitates the
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Canine immune cells express high levels of CB1 and CB2 cannabinoid receptors and cannabinoid-mediated alteration of canine cytokine production is vehicle-dependent Vet. Immunol. Immunopathol. (IF 1.8) Pub Date : 2023-10-31 Clare Brown, Matthew Mitsch, Karis Blankenship, Carly Campbell, Mimi Pelanne, Jaylan Sears, Abigail Bell, Alicia K. Olivier, Matthew K. Ross, Todd Archer, Barbara L.F. Kaplan
With the increased popularity and societal acceptance of marijuana and cannabidiol (CBD) use in humans, there is an interest in using cannabinoids in veterinary medicine. There have been a few placebo-controlled clinical trials in dogs suggesting that cannabis-containing extracts are beneficial for dogs with inflammatory diseases such as osteoarthritis, and there is growing interest in their immunosuppressive
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Validation of a commercially available photometric analytical system for assessment of plasma oxidative status in healthy horses Vet. Immunol. Immunopathol. (IF 1.8) Pub Date : 2023-10-30 Sarah A. Vaughn, Natalie A. Norton, David J. Hurley, Kelsey A. Hart
Reactive oxygen species (ROS) are the end-products of physiologic functions in health. Oxidative stress occurs when endogenous antioxidants are insufficient to neutralize ROS in the system. As a result, ROS can damage DNA, RNA, proteins, lipids, and cell organelles. To obtain accurate measurements of plasma oxidative stress, levels of both oxidants and antioxidants must be measured. This study validates
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Effects of oral administration of lipopolysaccharide derived from Pantoea agglomerans on innate immunity of mammary glands in dairy goats Vet. Immunol. Immunopathol. (IF 1.8) Pub Date : 2023-10-27 Naoki Suzuki, Fika Yuliza Purba, Hiroyuki Inagawa, Yoshinori Hattori, Naoki Isobe
This study aimed to evaluate the effect of orally administered lipopolysaccharide (LPS) derived from Pantoea agglomerans (LPSpa) on innate immune functions, including the concentrations of antimicrobial components and interleukin (IL)-10 in goat milk, for the prevention of goat mastitis. Twelve Tokara goats were divided into two groups of six goats. Goats in the LPSpa and control groups were orally
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Nanoparticulate chitosan-TNF-α-VLPs activate mast cells and enhance adaptive immunity induced by foot-and-mouth disease virus-like particles in mice Vet. Immunol. Immunopathol. (IF 1.8) Pub Date : 2023-10-15 Ruoman Bai, Mingzhu Li, Zhanyun Tian, Yiming Hu, Manxin An, Wanzhe Yuan, Limin Li
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Surface material of acoustic transmitters influences the inflammatory response of rainbow trout (Oncorhynchus mykiss) during long-term implantation Vet. Immunol. Immunopathol. (IF 1.8) Pub Date : 2023-10-06 George Heath, Shawna L. Semple, Tania Rodríguez-Ramos, Sarah Hardy, Philip Harrison, Ingeborg M. Mulder, Michael Power, Brian Dixon
Telemetry tags are a widely used technology for tracking animals that are difficult to observe in their natural environment. This technology has been increasingly used to monitor and study populations of high value salmonid species in Canadian waters. This study expands on a previous study of the impacts of tag implantation on the immune system of Rainbow Trout (Oncorhynchus mykiss). Pro-inflammatory
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Exploration of the potential utility of the luciferase immunoprecipitation system (LIPS) assay for the detection of anti-leptospira antibodies in dogs Vet. Immunol. Immunopathol. (IF 1.8) Pub Date : 2023-10-06 C. Taylor, E. Belin, D. Brodbelt, H.L.B.M. Klaasen, B. Catchpole
Canine leptospirosis represents a diagnostic challenge to veterinarians, due to the variability in presenting clinical signs and interpretation of serology test results in dogs that have been vaccinated previously. None of the commercially available serological assays, including the microscopic agglutination test (MAT), have been verified to be capable of differentiating infected from vaccinated animals
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Enhancing bovine tuberculosis screening at Dhaka city in Bangladesh: Integrating gamma interferon blood test as ancillary testing with tuberculin skin test Vet. Immunol. Immunopathol. (IF 1.8) Pub Date : 2023-09-30 Robiul Islam, Sk Shaheenur Islam, Tanzida Begum Rumi, Zakaria Mia, Zeaur Rahim
Tuberculin skin test (TST) is the standard method for screening of bovine tuberculosis (bTB). However, gamma interferon blood test has been introduced in the bTB control program as an ancillary testing with TST in many countries of the world. The objective of this study was to recommend this screening test as an ancillary testing with TST for field application in Bangladesh. In this study 577 cattle
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Down-regulating CD19 surface markers expression correlates with infectious bursal disease virus replication Vet. Immunol. Immunopathol. (IF 1.8) Pub Date : 2023-09-22 Shahla Shahsavandi, Samira Torabi, Mohammad Majid Ebrahimi, Mohammad Bagher Ghadiri
The infectious bursal disease virus (IBDV) causes an acute and highly contagious immunosuppressive response in young chickens by targeting B lymphocytes in immune organs. Changes in regulatory T-cell ratio and apoptosis have been demonstrated during IBDV infection in these cells. The possible change in CD19 expression as the precursor of B cells after IBDV replication was detected in this study. Raji
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Cattle killer immunoglobulin-like receptor expression on leukocyte subsets suggests functional divergence compared to humans Vet. Immunol. Immunopathol. (IF 1.8) Pub Date : 2023-08-22 Abigail L. Hay, James Birch, Shirley Ellis, Daniel Burns, Salah Mansour, Salim I. Khakoo, John A. Hammond
Cattle, sheep, and goats are the only species outside primates known to have an expanded and diversified family of killer immunoglobulin-like receptors (KIR). Primate KIR are expressed on the surface of NK and T cells and bind MHC-I to control activation. However, the surface expression, ligands and function of bovid KIR remain unknown. Cattle botaKIR2DL1 is the only functional KIR of the same DL-lineage
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Significant increase in MIC-A and MIC-B and soluble MIC-A and MIC-B in canine lymphomas Vet. Immunol. Immunopathol. (IF 1.8) Pub Date : 2023-08-25 Maresa Lopez-Montaño, Laura Jimenez-Ortega, Teresa Rocio Cruz-Hernandez, Victor Gabriel Hernandez-Chavez, Laura Arcelia Montiel-Cervantes, Elba Reyes-Maldonado, Jorge Vela-Ojeda
Non-Hodkin's lymphoma (NHL) is the most frequent hematologic malignancy in humans and dogs. NKG2D is one of the most critical receptors on NK cells, recognizing their natural ligands on malignant cells such as A and B major histocompatibility complex-related proteins (MIC-A and MIC-B). Soluble molecules (sMIC-A and sMIC-B) can interfere with immune synapsis between NK cells and tumor cells, impeding
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Determination of optimal storage time and temperature for the detection of red blood cell and platelet surface-associated immunoglobulin by flow cytometry in healthy horses Vet. Immunol. Immunopathol. (IF 1.8) Pub Date : 2023-08-14 Miranda Frohlich, Kaori Knights, Nora L. Springer
Differentiating immune-mediated causes from other causes of anemia and thrombocytopenia can be challenging. Flow cytometry can detect surface-associated immunoglobulin (sIg) on red blood cells (RBC) and platelets (PLT) in dogs and horses. Sample storage parameters for ideal assay performance has not been evaluated in horses. The study objective is to identify optimal storage time and temperature of
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Lymphocyte immunophenotyping and concentration of MMP-9 in transudates and exudates in horses Vet. Immunol. Immunopathol. (IF 1.8) Pub Date : 2023-08-12 Pavla Hamouzová, Olga Dobešová, Kristína Řeháková, Šárka Stehlíková, Petr Čížek, Zuzana Drábková, Petr Jahn, Jaroslav Doubek
This study is the first to provide information on the lymphocyte subpopulations in peritoneal effusions in horses. Peritoneal transudates (n = 12), peritoneal exudates (n = 6) and a pleural exudate (n = 1) were analyzed. The total nucleated cell count (TNCC), total protein (TP) and matrix metalloproteinase-9 (MMP-9) concentration determined by ELISA were measured and routine cytological evaluation
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Performance of two commercial serological assays for bovine tuberculosis using plasma samples Vet. Immunol. Immunopathol. (IF 1.8) Pub Date : 2023-08-10 Charlotte Moens, Claude Saegerman, David Fretin, Sylvie Marché
In the bovine tuberculosis diagnosis, the use of plasma samples (already available for IFNɣ assays) in serological tests might facilitate the work in the field. Here, the performance of two commercial serological tests (ELISA IDEXX M. bovis Ab test and Enferplex Bovine TB antibody test) were evaluated using plasma samples from cattle in Belgium. Specificity values estimated from 567 plasma samples
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The bovine leukemia virus infection prolongs immunosuppression in dairy cows during the periparturient period by sustaining higher expression of immunological checkpoints in T cells Vet. Immunol. Immunopathol. (IF 1.8) Pub Date : 2023-08-09 Alice Maria Melo do Nascimento, Carolina Menezes Suassuna de Souza, Ana Claudia Dumont Oliveira, Maiara Garcia Blagitz, Eduardo Milton Ramos Sanchez, Alice Maria Melville Paiva Della Libera, Ricardo de Miranda Henriques Leite, Artur Cezar de Carvalho Fernandes, Fernando Nogueira Souza
Bovine leukemia virus (BLV) is caused by a deltaretrovirus and has been associated with immunosuppression as well as comorbidities such as bovine mastitis, the costliest disease in the dairy sector. However, no previous study has explored at the synergistic immunosuppressive effect of the peripartum period with an immunosuppressive viral disease such as BLV. Thus, our study explored the effect of BLV
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Modulation of inflammatory and oxidative stress biomarkers due to dexamethasone exposure in chicken splenocytes Vet. Immunol. Immunopathol. (IF 1.8) Pub Date : 2023-07-26 Sonu Ambwani, Rigzin Dolma, Raunak Sharma, Amandip Kaur, Himani Singh, Anamitra Ruj, Tanuj Kumar Ambwani
Dexamethasone (DEXA) is a potent corticosteroid, commonly used for treating inflammatory, hypersensitive and allergic conditions. It is administered to birds with tumours. Many studies were conducted on its immunosuppressive effects; however none of the similar study is available employing chicken splenocytes culture system. The present study was conducted to assess DEXA induced alterations in inflammatory
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Long-term acute infections during a bovine viral diarrhea virus (BVDV) outbreak in dairy farm from Galicia (NW Spain) Vet. Immunol. Immunopathol. (IF 1.8) Pub Date : 2023-07-26 L. Nodar, I. Arnaiz, J.J. Pedreira, J. Díez, C. Calvo, J.F. Diéguez
An observational study describes an outbreak of bovine viral diarrhea virus (BVDV) in a dairy herd in Spain. The herd was subjected to a voluntary control program. In a sampling carried out in June 2020, bulk tank milk antibody levels increased compared to the previous sampling. Additionally, serum samples from 4 young heifers also tested positive for antibodies. Since the results were consistent with
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The serological detection of Bovine papillomavirus’s E5 oncoprotein antibodies in horses Vet. Immunol. Immunopathol. (IF 1.8) Pub Date : 2023-07-26 R. Hoikhman, D. Molinková, D. Pillárová, P. Linhart, A. Kopecká, P. Jahn
Equine sarcoids (ES) are known globally as the most frequent skin tumour affecting horses. These tumours affect the horse’s monetary value, they can affect the horse’s welfare and can be difficult and expensive to treat. Bovine papillomavirus (BPV) is considered to be the aetiological agent of this tumour, as BPV 1, 2 and 13 have been detected in ES. This is the only known natural cross species infection