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Neuroprotective Role of Phytoconstituents-based Nanoemulsion for the Treatment of Alzheimer’s Disease Curr. Topics Med. Chem. (IF 3.4) Pub Date : 2024-04-27 Sukriti Vishwas, Bushra Bashir, Devendra Birla, Nikhil Khandale, Motamarri Venkata Naga Lalitha Chaitanya, Dinesh Kumar Chellappan, Gaurav Gupta, Poonam Negi, Kamal Dua, Sachin Kumar Singh
: Alzheimer's disease (AD) is the most prevalent form of neurodegenerative disorder (ND), affecting more than 44 million individuals globally as of 2023. It is characterized by cognitive dysfunction and an inability to perform daily activities. The progression of AD is associated with the accumulation of amyloid beta (Aβ), the formation of neurofibrillary tangles (NFT), increased oxidative stress,
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The Current Landscape in the Development of Small-molecule Modulators Targeting Sphingosine-1-phosphate Receptors to Treat Neurodegenerative Diseases Curr. Topics Med. Chem. (IF 3.4) Pub Date : 2024-04-27 Sidharth Sankar Kar, Soumya Ranjan Gharai, Sujit Kumar Sahu, V. Ravichandiran, Sharada Prasanna Swain
: Sphingosine 1-phosphate (S1P) is extensively researched as a lysophospholipid and is crucial in various physiological and pathological processes. It achieves this via signalling through five different subtypes of G protein-coupled receptors (GPCRs), namely S1PR1 to S1PR5. S1PR modulators possess the ability to traverse the blood-brain barrier, potentially leading to direct ac-tions within the Central
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A New Approach to Melanoma Treatment: microRNAs Curr. Topics Med. Chem. (IF 3.4) Pub Date : 2024-04-27 Suleyman Ilhan, Ferdi Oguz, Harika Atmaca
:: Although immunotherapy and targeted therapy have radically changed melanoma treatment, the development of resistance and reduction of patient responses are still significant problems. Small molecule inhibitors are needed to overcome this situation, and biomarkers that can estimate whether patients will reply to existing treatments need to be developed. miRNAs are involved in diverse processes such
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Antioxidative and Anti-inflammatory Effects of Plant-derived Hypoglycemic Medicines: An In vivo/In vitro Systematic Review Curr. Topics Med. Chem. (IF 3.4) Pub Date : 2024-04-22 Mohammad Sadegh Adel-Mehraban, Ozra Tabatabaei-Malazy, Azadeh Manayi, Sudabeh Alatab, Shahrzad Mohseni, Saeed Ebrahimi Fana, Pooria Asili, Roodabeh Bahramsoltani, Fataneh Esmaeili, Bayan Azizi
Background: The activation of oxidative stress and inflammatory conditions has been associated with acceleration in diabetes (DM) onset and complications. Despite various anti-DM medications, there is a growing trend to discover inexpensive and effective treatments with low adverse effects from plants as one of the promising sources for drug development. Objective: This study aimed to systematically
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The Gold Standard Diagnosis of Schizophrenia is Counterproductive: Towards Quantitative Research and Diagnostic Algorithmic Rules (RADAR) and their Derived Qualitative Distinct Classes Curr. Topics Med. Chem. (IF 3.4) Pub Date : 2024-04-22 Michael Maes
: Recently, we developed Research and Diagnostic Algorithm Rules (RADAR) to assess the clinical and pathway features of mood disorders. The aims of this paper are to review a) the methodology for developing continuous RADAR scores that describe the clinical and pathway features of schizophrenia, and b) a new method to visualize the clinical status of patients and the pathways implicated in RADAR graphs
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Navigating the Alzheimer's Treatment Landscape: Unraveling Amyloid-Beta Complexities and Pioneering Precision Medicine Approaches Curr. Topics Med. Chem. (IF 3.4) Pub Date : 2024-04-22 Mohsina Patwekar, Faheem Patwekar, Shahzad khan, Rohit Sharma, Dileep Kumar
: A variety of cutting-edge methods and good knowledge of the illness's complex causes are causing a sea change in the field of Alzheimer's Disease (A.D.) research and treatment. Precision medicine is at the vanguard of this change, where individualized treatment plans based on genetic and biomarker profiles give a ray of hope for customized therapeutics. Combination therapies are becoming increasingly
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Nutritional Value, Therapeutic Effects, Phytochemistry, and Toxicology of Lepisanthes fruticosa: A Review Curr. Topics Med. Chem. (IF 3.4) Pub Date : 2024-04-19 Lim Joe Siang, Harish Rajak, Veerasamy Ravichandran
The multifaceted benefits of Lepisanthes fruticosa position it is not only as a promising agricultural commodity but also as a versatile resource with implications for health, biodiversity, and economic growth. Lepisanthes fruticosa has a rich history of traditional use for treating various ailments such as fever and diarrhea. Beyond its traditional uses, the plant's antioxidant properties suggest
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Noncoding RNAs in Alzheimer’s Disease: Overview of Functional and Therapeutic Significance Curr. Topics Med. Chem. (IF 3.4) Pub Date : 2024-04-15 Divya Adiga, Sangavi Eswaran, S Sriharikrishnaa, Nadeem G. Khan, Dileep Kumar, Shama Prasada Kabekkodu
: Alzheimer’s disease (AD) is a multifactorial disorder resulting from the complex interaction between genetic, epigenetic, and environmental factors. It represents an impending epidemic and lacks effective pharmacological interventions. The emergence of high throughput sequencing techniques and comprehensive genome evaluation has uncovered a diverse spectrum of non-- coding RNA (ncRNA) families. ncRNAs
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Food-Derived Peptides as Promising Neuroprotective Agents: Mechanism and Therapeutic Potential Curr. Topics Med. Chem. (IF 3.4) Pub Date : 2024-04-13 Kavita Patel, Ashutosh Mani
: Many food-derived peptides have the potential to improve brain health and slow down neurodegeneration. Peptides are produced by the enzymatic hydrolysis of proteins from different food sources. These peptides have been shown to be involved in antioxidant and anti-inflammatory activity, neuro-transmission modulation, and gene expression regulation. Although few peptides directly affect chromatin remodeling
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Prominent Perspective on Existing Biological Hallmarks of Alzheimer’s Disease Curr. Topics Med. Chem. (IF 3.4) Pub Date : 2024-04-09 Namrata Singh, Srishti Sharma, Kallol K. Ghosh, Bhanushree Gupta, Kamil Kuca
:: Biomarkers are the most significant diagnosis tools tending towards unique approaches and solutions for the prevention and cure of Alzheimer’s Disease (AD). The current report provides a clear perception of the concept of various biomarkers and their prominent features through analysis to provide a possible solution for the inhibition of events in AD. Scientists around the world truly believe that
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Alleviating Neurodegenerative Diseases Associated with Mitochondrial Defects by Therapeutic Biomolecules Curr. Topics Med. Chem. (IF 3.4) Pub Date : 2024-04-09 Tanmoy Roy, Swarupanjali Padhi, Rupa Mazumder, Chandana Majee, Saumya Das, Monika Monika, Rashmi Mishra, Bhupinder Kapoor
: Neurodegenerative diseases are emerging as a global health concern in the current sce-nario, and their association with mitochondrial defects has been a potential area of research. Mi-tochondria, one of the essential organelles of the cell, serve as the cell's powerhouse, producing energy and ensuring cellular health. Neurodegenerative diseases such as Alzheimer's, Parkinson's, Huntington's, amyotrophic
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Quinolone Derivatives as Anticancer Agents: Importance in Medicinal Chemistry Curr. Topics Med. Chem. (IF 3.4) Pub Date : 2024-04-09 Nursyuhada Azzman, Sirajudheen Anwar, Wan Ahmad Syazani Mohamed, Nafees Ahemad
:: Quinolone is a heterocyclic compound containing carbonyl at the C-2 or C-4 positions with nitrogen at the C-1 position. The scaffold was first identified for its antibacterial properties, and the derivatives were known to possess many pharmacological activities, including anticancer. In this review, the quinolin-2(H)-one and quinolin-4(H)-one derivatives were identified to inhibit several various
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Antimicrobial Potential of Natural Compounds of Zingiberaceae Plants and their Synthetic Analogues: A Scoping Review of In vitro and In silico Approaches Curr. Topics Med. Chem. (IF 3.4) Pub Date : 2024-04-05 Kok-Hou Yit, Zamirah Zainal-Abidin
Aim:: There has been increased scientific interest in bioactive compounds and their synthetic derivatives to promote the development of antimicrobial agents that could be used sustainably and overcome antibiotic resistance. Methods:: We conducted this scoping review to collect evidence related to the antimicrobial potential of diverse natural compounds from Zingiberaceae plants and their synthetic
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Nanomaterial-based Electrochemical Sensors for Multiplex Medicinal Applications Curr. Topics Med. Chem. (IF 3.4) Pub Date : 2024-04-05 Surinya Traipop, Whitchuta Jesadabundit, Wisarut Khamcharoen, Tavechai Pholsiri, Sarida Naorungroj, Sakda Jampasa, Orawon Chailapakul
:: This review explores the advancements in nanomaterial-based electrochemical sensors for the multiplex detection of medicinal compounds. The growing demand for efficient and selective detection methods in the pharmaceutical field has prompted significant research into the development of electrochemical sensors employing nanomaterials. These materials, defined as functional materials with at least
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Recent Advances in the Treatment and Management of Alzheimer’s Disease: A Precision Medicine Perspective Curr. Topics Med. Chem. (IF 3.4) Pub Date : 2024-04-03 Deepali Shukla, Anjali Suryavanshi, Sanjay Kumar Bharti, Vivek Asati, Debarshi Kar Mahapatra
: About 60% to 70% of people with dementia have Alzheimer's Disease (AD), a neuro-degenerative illness. One reason for this disorder is the misfolding of naturally occurring proteins in the human brain, specifically β-amyloid (Aβ) and tau. Certain diagnostic imaging techniques, such as amyloid PET imaging, tau PET imaging, Magnetic Resonance Imaging (MRI), Comput-erized Tomography (CT), and others
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The Role of Selenium Nanoparticles in Addressing Diabetic Complications: A Comprehensive Study Curr. Topics Med. Chem. (IF 3.4) Pub Date : 2024-04-02 Siddharth Satpathy, Lipsa Leena Panigrahi, Manoranjan Arakha
:: Diabetes, as an emerging epidemic, has put forward a significant spotlight on the evolving population worldwide grounded upon the remarkable affliction of healthcare along with economical conflict. Various studies suggested that, in modern society, lack of maintenance of a healthy life style leads to the occurrence of diabetes as insulin resistant, later having a damaging effect on the pancreatic
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Approaches Towards Better Immunosuppressive Agents Curr. Topics Med. Chem. (IF 3.4) Pub Date : 2024-04-02 Juliusz Walczak, Dorota Iwaszkiewicz-Grześ, Grzegorz Cholewiński
: Several classes of compounds are applied in clinics due to their immunosuppressive properties in transplantology and the treatment of autoimmune diseases. Derivatives of mycophe-nolic acid, corticosteroids and chemotherapeutics bearing heterocyclic moieties like methotrexate, azathioprine, mizoribine, and ruxolitinib are active substances with investigated mechanisms of action. However, improved
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Use of Immunoglobulin Y Antibodies: Biosensor-based Diagnostic Systems and Prophylactic and Therapeutic Drug Delivery Systems for Viral Respiratory Diseases Curr. Topics Med. Chem. (IF 3.4) Pub Date : 2024-04-02 Yasemin Budama-Kilinc, Ozan Baris Kurtur, Bahar Gok, Nisanur Cakmakci, Serda Kecel-Gunduz, Necdet Mehmet Unel, Taylan Kurtulus Ozturk
:: Respiratory viruses have caused many pandemics from past to present and are among the top global public health problems due to their rate of spread. The recently experienced COVID-19 pandemic has led to an understanding of the importance of rapid diagnostic tests to prevent epidemics and the difficulties of developing new vaccines. On the other hand, the emergence of resistance to existing antiviral
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Polymer Conjugate as the New Promising Drug Delivery System for Combination Therapy against Cancer Curr. Topics Med. Chem. (IF 3.4) Pub Date : 2024-03-29 Qiang Hu, Yuannian Zhang, Jean Felix Mukerabigwi, Haili Wang, Yu Cao
: This review highlights the advantages of combination therapy using polymer conjugates as drug delivery systems for cancer treatment. In this review, the specific structures and materials of polymer conjugates, as well as the different types of combination chemotherapy strategies, are discussed. Specific targeting strategies, such as monoclonal antibody therapy and small molecule ligands, are also
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Gallic Acid Derived 1, 2-Diarylindole as a Potential Antifungal Agent against Candida Strain Curr. Topics Med. Chem. (IF 3.4) Pub Date : 2024-03-29 Alka Kurmi, Akash Pratap Singh, Yashveer Gautam, Nandan Singh, Alok Tripathi, Arvind Singh Negi, Hemant K. Gautam, Anirban Pal, Dharmendra Saikia
Background: In recent decades, Candida albicans has become a serious issue for public health. The worldwide rapid rise in drug resistance to conventional therapies is the main contributing reason. Moreover, because of their potent activity at low concentrations and apparent lack of toxicity, compounds originating from plants are used in therapeutic treatments because of their potent activity at low
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Immunomodulatory Effect of Phytoactive Compounds on Human Health: A Narrative Review Integrated with Bioinformatics Approach Curr. Topics Med. Chem. (IF 3.4) Pub Date : 2024-03-29 Saumya Choudhary, Sheeba Khan, Shivani Rustagi, Vijay Rani Rajpal, Noor Saba Khan, Neeraj Kumar, George Thomas, Anamika Pandey, Mehmet Hamurcu, Sait Gezgin, Sajad Majeed Zargar, Mohd Kamran Khan
Background: Immunomodulation is the modification of immune responses to control disease progression. While the synthetic immunomodulators have proven efficacy, they are coupled with toxicity and other adverse effects, and hence, the efforts were to identify natural phytochemicals with immunomodulatory potential. Objective: The objective of this study is to understand the immunomodulatory properties
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Phytochemicals for Cancer Treatment: An Update on Plant-Derived Anti-Cancer Compounds and their Mechanisms of Action Curr. Topics Med. Chem. (IF 3.4) Pub Date : 2024-03-29 Sana Ullah, Tariq Khan, Taimoor Khan, Muhammad Ali, Abdul Khaliq Jan, Zabta Khan Shinwari, Ajmal Khan, Mohamed Al-Farsi, Muhammad Waqas
: Cancer remains one of the major causes of morbidity and mortality worldwide. Scientists from different fields are working to devise an efficient treatment strategy in order to reduce the global burden of cancer. Commonly used treatment approaches for cancer treatment include chemotherapy, immunotherapy, photodynamic therapy, radiation, surgery, etc. These treatment procedures have several pitfalls
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A New Advanced Approach: Design and Screening of Affinity Peptide Ligands Using Computer Simulation Techniques Curr. Topics Med. Chem. (IF 3.4) Pub Date : 2024-03-29 Zheng Wei, Meilun Chen, Xiaoling Lu, Yijie Liu, Guangnan Peng, Jie Yang, Chunhua Tang, Peng Yu
: Peptides acquire target affinity based on the combination of residues in their sequences and the conformation formed by their flexible folding, an ability that makes them very attractive biomaterials in therapeutic, diagnostic, and assay fields. With the development of computer technology, computer-aided design and screening of affinity peptides has become a more efficient and faster method. This
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Green Synthesis of Biorelevant Scaffolds through Organocatalytic/ Enzymatic Dynamic Kinetic Resolution Curr. Topics Med. Chem. (IF 3.4) Pub Date : 2024-03-28 Hélène Pellissier
:: This review highlights major developments in the application of green organocatalytic and enzymatic dynamic kinetic resolutions (DKRs) in the total synthesis of biorelevant scaffolds. It illustrates the diversity of useful bioactive products and intermediates that can be synthesized under greener and more economic conditions through the combination of the powerful concept of DKR, which allows the
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Synthesis and In Vitro and Silico Anti-inflammatory Activity of New Thiazolidinedione-quinoline Derivatives Curr. Topics Med. Chem. (IF 3.4) Pub Date : 2024-03-25 Sandra Elizabeth Barbosa da Silva, José Arion da Silva Moura, Jeann Fabiann Branco Júnior, Paulo André Teixeira de Moraes Gomes, Simão Kalebe Silva de Paula, Douglas Carvalho Francisco Viana, Eduardo Augusto Vasconcelos de Freitas Ramalho, João Victor de Melo Gomes, Michelly Cristiny Pereira, Maira Galdino da Rocha Pitta, Ivan da Rocha Pitta, Marina Galdino da Rocha Pitta
Background: Inflammation is a series of complex defense-related reactions. The inflammation cascade produces various pro-inflammatory mediators. Unregulated production of these pro-inflammatory mediators can lead to a wide range of diseases, including rheumatoid arthritis, sepsis, and inflammatory bowel disease. In the literature, the anti-inflammatory action of quinoline and thiazolidinedione nuclei
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Synthetic Strategies of Thiazolidine-2,4-dione Derivatives for the Development of New Anti-diabetic Agents: Compressive Review Curr. Topics Med. Chem. (IF 3.4) Pub Date : 2024-03-18 Pushkar Kumar Ray, Km Shabana, Salahuddin, Rajnish Kumar
Background: Thiazolidine-2,4-dione (2,4-TZD) is a flexible pharmacophore and a privileged platform and contains a five-membered ring with a 2-oxygen atom with double bond 2,4- position and one nitrogen atom as well as sulphur containing in the heterocyclic compound. A famous electron-rich nitrogen transporter combines invigorating electronic properties with the prospective for elemental applications
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Immunomodulatory Plant Natural Products as Therapeutics against Inflammatory Skin Diseases Curr. Topics Med. Chem. (IF 3.4) Pub Date : 2024-03-15 Nikhila Sampath Kumar, Navaneetha Reddy, Halmuthur Kumar, Sravanthi Vemireddy
: Frequently occurring inflammatory skin conditions such as psoriasis, dermatitis, acne, including skin cancer, wounds and other disorders arising out of premature skin aging, deteriorate skin health and adversely impact human life. Even though several synthetic compounds have evolved for treating these skin conditions, natural-product-based therapeutics are gaining popularity with growing evidence
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Actinomycetes - The Repertoire of Diverse Bioactive Chemical Molecules: From Structures to Antibiotics Curr. Topics Med. Chem. (IF 3.4) Pub Date : 2024-03-15 Ishfaq Ahmad Baba, Zubair Ahmad Wani, Shazia Ali, Zahoor Ahmad, Mohamad Mosa Mubarak
: The urgent need for novel antibiotics in the face of escalating global antimicrobial resistance necessitates innovative approaches to identify bioactive compounds. Actinomycetes, renowned for their prolific production of antimicrobial agents, stand as a cornerstone in this pursuit. Their diverse metabolites exhibit multifaceted bioactivities, including potent antituberculosis, anticancer, immunomodulatory
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Tetrandrine for Targeting Therapy Resistance in Cancer Curr. Topics Med. Chem. (IF 3.4) Pub Date : 2024-03-06 Ellen Nogueira Lima, Santosh Lamichhane, KC Pramod, Elisa Silva Ferreira, Hari K. Koul, Sweaty Koul
: During the last five decades, there has been tremendous development in our understanding of cancer biology and the development of new and novel therapeutics to target cancer. However, despite these advances, cancer remains the second leading cause of death across the globe. Most cancer deaths are attributed to the development of resistance to current therapies. There is an urgent and unmet need to
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Highlights on Fluorine-containing Drugs Approved by U.S. FDA in 2023 Curr. Topics Med. Chem. (IF 3.4) Pub Date : 2024-03-05 Saghir Ali, Andrew A. Bolinger, Jia Zhou
Fluorine continues to show its potential applications in drug discovery and development, as reflected by twelve drugs being fluorinated out of the fifty-five approved by the FDA in 2023. This concise review highlights the discovery of each of these fluorine-containing drugs in the past year, including its brand name, date of approval, composition, sponsors, indication, and mechanism of action. The
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Ginsenoside Rg3: A Review of its Anticancer Mechanisms and Potential Therapeutic Applications Curr. Topics Med. Chem. (IF 3.4) Pub Date : 2024-03-04 Lei Wu, Lin Bai, Wenshu Dai, Yaping Wu, Pengjun Xi, Jie Zhang, Lily Zheng
Background: Traditional Chinese Medicine (TCM) has a long history of treating various diseases and is increasingly being recognized as a complementary therapy for cancer. A promising natural compound extracted from the Chinese herb ginseng is ginsenoside Rg3, which has demonstrated significant anticancer effects. It has been tested in a variety of cancers and tumors and has proven to be effective in
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Microfluidics-mediated Liposomal Nanoparticles for Cancer Therapy: Recent Developments on Advanced Devices and Technologies Curr. Topics Med. Chem. (IF 3.4) Pub Date : 2024-03-01 Seyed Morteza Naghib, Kave Mohammad-Jafari
: Liposomes, spherical particles with phospholipid double layers, have been extensively studied over the years as a means of drug administration. Conventional manufacturing techniques like thin-film hydration and extrusion have limitations in controlling liposome size and distribution. Microfluidics enables superior tuning of parameters during the self-assembly of liposomes, producing uniform populations
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The Unveiling of Therapeutic Targets for Alzheimer’s Disease: An Integrative Review Curr. Topics Med. Chem. (IF 3.4) Pub Date : 2024-02-28 Pratiksha Madar, Pooja Nagalapur, Somdatta Chaudhari, Devesh Sharma, Akshada Koparde, Rahul Buchade, Sandip Kshirsagar, Pravin Uttekar, Shailaja Jadhav, Praveen Chaudhari
Alzheimer's disease (AD) is characterized by a complex pathological landscape, necessitating a comprehensive treatment approach. This concise review paper delves into the idea of addressing multiple mechanisms in AD, summarizing the latest research findings on pathogenesis, risk factors, diagnostics, and therapeutic strategies. The etiology of AD is multifaceted, involving genetic, environmental, and
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The Advancement and Obstacles in Improving the Stability of Nanocarriers for Precision Drug Delivery in the Field of Nanomedicine Curr. Topics Med. Chem. (IF 3.4) Pub Date : 2024-02-22 Kalpesh Mahajan, Sankha Bhattacharya
Nanocarriers have emerged as a promising class of nanoscale materials in the fields of drug delivery and biomedical applications. Their unique properties, such as high surface area- tovolume ratios and enhanced permeability and retention effects, enable targeted delivery of therapeutic agents to specific tissues or cells. However, the inherent instability of nanocarriers poses significant challenges
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Recent Trends in Nanomaterial Based Electrochemical Sensors for Drug Detection: Considering Green Assessment Curr. Topics Med. Chem. (IF 3.4) Pub Date : 2024-02-22 Tugba Ozer, Charles S. Henry
: An individual’s therapeutic drug exposure level is directly linked to corresponding clinical effects. Rapid, sensitive, inexpensive, portable and reliable devices are needed for diagnosis related to drug exposure, treatment, and prognosis of diseases. Electrochemical sensors are useful for drug monitoring due to their high sensitivity and fast response time. Also, they can be combined with portable
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Repurposing of Plant-based Antiviral Molecules for the Treatment of COVID-19 Curr. Topics Med. Chem. (IF 3.4) Pub Date : 2024-02-22 Jabeena Khazir, Rakesh Kr Thakur, Sajad Ahmed, Manzoor Hussain, Sumit G. Gandhi, Sadhana Babbar, Shabir Ahmad Mir, Nusrat Shafi, Libert Brice Tonfack, Vijay Rani Rajpal, Tariq Maqbool, Bilal Ahmad Mir, Latif Ahmad Peer
: COVID-19, stemming from SARS-CoV-2, poses a formidable threat to global healthcare, with a staggering 77 million confirmed cases and 690,067 deaths recorded till Decem-ber 24, 2023. Given the absence of specific drugs for this viral infection, the exploration of novel antiviral compounds becomes imperative. High-throughput technologies are actively engaged in drug discovery, and there is a parallel
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Ciprofloxacin and Norfloxacin Hybrid Compounds: Potential Anticancer Agents Curr. Topics Med. Chem. (IF 3.4) Pub Date : 2024-02-15 Sijongesonke Peter, Blessing A. Aderibigbe
Background:: The concept of utilizing drug repurposing/repositioning in the development of hybrid molecules is an important strategy in drug discovery. Fluoroquinolones, a class of antibiotics, have been reported to exhibit anticancer activities. Although anticancer drug development is achieving some positive outcomes, there is still a need to develop new and effective anticancer drugs. Some limitations
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The Role of Herbal Medicine in Modulating Bone Homeostasis Curr. Topics Med. Chem. (IF 3.4) Pub Date : 2024-02-09 Xinnan Cheng, Shanshan Jin, Mingzhe Feng, Yunfeng Miao, Baorong He, Qi Dong
: Osteoporosis and other bone diseases are a major public health concern worldwide. Current pharmaceutical treatments for bone disorders have limitations, driving interest in complementary herbal medicines that can help maintain bone health. This review summarizes the scientific evidence for medicinal herbs that modulate bone cell activity and improve bone mass, quality and strength. Herbs with osteogenic
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Nitrosamines, ICH Q3A-Q3E, Global Substance Registration System (GSRS), N-nitroso dimethyl amine (NDMA), Drug substance life cycle. Curr. Topics Med. Chem. (IF 3.4) Pub Date : 2024-02-07 Darshan Bhirud, Gyan Agrawal, Harshil Shah, Artiben Patel, Mahesh B. Palkar, Sankha Bhattacharya, Bhupendra G. Prajapati
: Since their discovery in valsartan-containing drugs, nitrosamine impurities have emerged as a significant safety problem in pharmaceutical products, prompting extensive recalls and suspensions. Valsartan, candesartan, irbesartan, olmesartan, and other sartans have been discovered to have additional nitrosamine impurities, such as N-nitroso-N-methyl-4-aminobutyric acid (NMBA), N-nitroso-Di-isopropyl
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Pyrazoline Derivatives as Promising MAO-A Targeting Antidepressants: An Update Curr. Topics Med. Chem. (IF 3.4) Pub Date : 2024-02-02 Diksha Choudhary, Rajwinder Kaur, Thakur Gurjeet Singh, Bhupinder Kumar
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Combating COVID-19 Crisis using Artificial Intelligence (AI) Based Approach: Systematic Review Curr. Topics Med. Chem. (IF 3.4) Pub Date : 2024-02-02 Kavya Singh, Navjeet Kaur, Ashish Prabhu
Background: SARS-CoV-2, the unique coronavirus that causes COVID-19, has wreaked damage around the globe, with victims displaying a wide range of difficulties that have encouraged medical professionals to look for innovative technical solutions and therapeutic approaches. Artificial intelligence-based methods have contributed a significant part in tackling complicated issues, and some institutions
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Valeriana jatamansi: Bioactive Compounds and their Medicinal Uses Curr. Topics Med. Chem. (IF 3.4) Pub Date : 2024-02-02 Antim K. Maurya, Vijai K. Agnihotri
Valeriana jatamansi is a reputed perennial medicinal herb distributed throughout the world, where it is used in cytotoxicity, neuronal problems, insomnia, leishmania and acetylcholinesterase inhibitor, antioxidant, antiviral and α-glucosidase inhibition activities. This review describes the current state of chemical characterization of isolated metabolites, which are well accepted for the treatment
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Molecular Biomarkers in Cholangiocarcinoma: Focus on Bile Curr. Topics Med. Chem. (IF 3.4) Pub Date : 2024-01-31 Andrey D. Dolbnya, Igor A. Popov, Stanislav I. Pekov
Hepatobiliary system cancers have demonstrated an increasing incidence rate in the past years. Without the presence of early symptoms, the majority of such cancers manifest with a set of similar symptoms, such as cholestasis resulting in posthepatic icterus. Differential diagnosis of hepatobiliary cancers is required for the therapy selection, however, the similarity of the symptoms complicates diagnostics
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Recent Developments and Future Perspectives of Purine Derivatives as a Promising Scaffold in Drug Discovery Curr. Topics Med. Chem. (IF 3.4) Pub Date : 2024-01-29 Neha Rana, Parul Grover, Hridayanand Singh
: Numerous purine-containing compounds have undergone extensive investigation for their medical efficacy across various diseases. The swift progress in purine-based medicinal chemistry has brought to light the therapeutic capabilities of purine-derived compounds in addressing challenging medical conditions. Defined by a heterocyclic ring comprising a pyrimidine ring linked with an imidazole ring, purine
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An Update on Pharmacological and Phytochemical Aspects of Costus pictus D. Don - A Promising Anti-diabetic Plant Curr. Topics Med. Chem. (IF 3.4) Pub Date : 2024-01-29 Vipin Kumar Singh, Kuldeep Singh Yadav, Shiny C. Thomas, Ambika Gupta, Suaib Luqman, Karuna Shanker, Umesh Kumar Patil, Narayan Prasad Yadav
Background: The genus Costus is the largest genus in the family Costaceae and encompasses about 150 known species. Among these, Costus pictus D. Don (Synonym: Costus mexicanus) is a traditional medicinal herb used to treat diabetes and other ailments. Currently, available treatment options in modern medicine have several adverse effects. Herbal medicines are gaining importance as they are cost-effective
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The Mushroom Albatrellus confluens: A Minireview on Phytochemistry, Biosynthesis, Synthesis and Pharmacological Activities Curr. Topics Med. Chem. (IF 3.4) Pub Date : 2024-01-29 Ninh The Son, Chu Anh Van
Background: Albatrellus confluens is one of the representative species in the Polyporaceae family. Its major mero terpenoid grifolin and related compounds have the potential for drug applications. Objective: The current study aims to briefly provide an insightful view of the phytochemistry, biosynthesis, synthesis, and pharmacology of A. confluens metabolites Methods: Data collection was performed
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Targeted Cancer Stem Cell Therapeutics: An Update Curr. Topics Med. Chem. (IF 3.4) Pub Date : 2024-01-29 Naurin Fatima, Mohammad Umar, Subiya Ambreen, Mohd Shaququzzaman, Mohammad Mumtaz Alam, Ruhi Ali
: Cancer stem cells (CSCs) have become a key player in the growth of tumors, the spread of cancer, and the resistance to therapeutic interventions. Targeting these elusive cell populations has the potential to fundamentally alter cancer treatment plans. CSCs, also known as tumor-initiating cells (TICs), are thought to play a role in both medication resistance and cancer recurrence. This is explained
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Deciphering Tuberculous Meningitis: From Clinical Challenges to Novel Models and Pathogenic Pathways Curr. Topics Med. Chem. (IF 3.4) Pub Date : 2024-01-29 Mohamad Mosa Mubarak, Shahnawaz Majeed, Hadiya Amin Kantroo, Zubair Ahmad Wani, Abbass Malik, Zahoor Ahmad, Ishfaq Ahmad Baba
: During and after the COVID-19 pandemic,Tuberculosis (TB) has reestablished with higher figures due to interruptions in the Directly Observed Treatment Short course (DOTS) despite underreporting. The rising consequences would have extended to extra-pulmonary forms of TB as well, including Tuberculous Meningitis (TBM). Considering the fact that TBM is the most dangerous and worst form of TB, we found
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Tackling Nontuberculous Mycobacteria by Repurposable Drugs and Potential Leads from Natural Products Curr. Topics Med. Chem. (IF 3.4) Pub Date : 2024-01-29 Patil Amruta Adhikrao, Gudle Mayuri Motiram, Gautam Kumar
: Nontuberculous Mycobacteria (NTM) refer to bacteria other than all Mycobacterium species that do not cause tuberculosis or leprosy, excluding the species of the Mycobacterium tu-berculosis complex, M. leprae and M. lepromatosis. NTM are ubiquitous and present in soils and natural waters. NTM can survive in a wide range of environmental conditions. The direct inocu-lum of the NTM from water or other
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Phytotherapeutics in Cancer: From Potential Drug Candidates to Clinical Translation Curr. Topics Med. Chem. (IF 3.4) Pub Date : 2024-01-26 Parul Grover, Kulbhushan Thakur, Monika Bhardwaj, Lovekesh Mehta, Soom Nath Raina, Vijay Rani Rajpal
: Annually, a significant number of individuals succumb to cancer, an anomalous cellular condition characterized by uncontrolled cellular proliferation and the emergence of highly perilous tumors. Identifying underlying molecular mechanism(s) driving disease progression has led to various inventive therapeutic approaches, many of which are presently under pre-clinical and/or clinical trials. Over the
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P-coumaric Acid: Advances in Pharmacological Research Based on Oxidative Stress Curr. Topics Med. Chem. (IF 3.4) Pub Date : 2024-01-25 Feixiang Chen, Xinxin Zhang, Junxiang Wang, Fukai Wang, Jinlong Mao
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Anti-COVID-19 Potential of Withaferin-A and Caffeic Acid Phenethyl Ester Curr. Topics Med. Chem. (IF 3.4) Pub Date : 2024-01-24 Vipul Kumar, Anissa Nofita Sari, Dharmender Gupta, Yoshiyuki Ishida, Keiji Terao, Sunil C. Kaul, Sudhanshu Vrati, Durai Sundar, Renu Wadhwa
Background: The recent COVID-19 (coronavirus disease 2019) pandemic triggered research on the development of new vaccines/drugs, repurposing of clinically approved drugs, and assessment of natural anti-COVID-19 compounds. Based on the gender difference in the severity of the disease, such as a higher number of men hospitalized and in intense care units, variations in sex hormones have been predicted
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Neurobiochemical Disturbances in Psychosis and their Implications for Therapeutic Intervention Curr. Topics Med. Chem. (IF 3.4) Pub Date : 2024-01-24 Georgi Panov, Presyana Panova
: Psychosis, marked by the emergence of psychotic symptoms, delves into the intricate dance of neurotransmitter dynamics, prominently featuring dopamine as a key orchestrator. In individuals living with psychotic conditions, the finely tuned balance of dopamine becomes disrupted, setting off a cascade of perceptual distortions and the manifestation of psychotic symptoms. A lot of factors can impact
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The Role of Cytokines in Activation of Tumour-promoting Pathways and Emergence of Cancer Drug Resistance Curr. Topics Med. Chem. (IF 3.4) Pub Date : 2024-01-23 Ekta Shirbhate, Vaibhav Singh, Rakesh Kore, Subham Vishwakarma, Ravichandran Veerasamy, Amit K. Tiwari, Harish Rajak
: Scientists are constantly researching and launching potential chemotherapeutic agents as an irreplaceable weapon to fight the battle against cancer. Despite remarkable advancement over the past several decades to wipe out cancer through early diagnosis, proper prevention, and timely treatment, cancer is not ready to give up and leave the battleground. It continuously tries to find some other way
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The Neurobiology of Formal Thought Disorder Curr. Topics Med. Chem. (IF 3.4) Pub Date : 2024-01-21 Erik Dornelles, Diogo Telles Correia
: The concept of Formal Thought Disorder (FTD) is an ambiguous and disputed one, even though it has endured as a core psychopathological construct in clinical Psychiatry. FTD can be summarized as a multidimensional construct, reflecting difficulties or idiosyncrasies in thinking, language, and communication in general and is usually subdivided into positive versus negative. In this article, we aim
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Recent Advances in Metallic Nanostructures-Assisted Biosensors for Medical Diagnosis and Therapy Curr. Topics Med. Chem. (IF 3.4) Pub Date : 2024-01-21 Ecem Tiryaki, Tolga Zorlu
: The field of nanotechnology has witnessed remarkable progress in recent years, particularly in its application to medical diagnosis and therapy. Metallic nanostructures-assisted biosensors have emerged as a powerful and versatile platform, offering unprecedented opportunities for sensitive, specific, and minimally invasive diagnostic techniques, as well as innovative therapeutic interventions. These
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Unlocking the Pharmacological Potential of Benzimidazole Derivatives: A Pathway to Drug Development Curr. Topics Med. Chem. (IF 3.4) Pub Date : 2024-01-19 Jyoti Monga, Niladry S. Ghosh, Isha Rani, Ranjit Singh, Geeta Deswal, Ashwani K. Dhingra, Ajmer S. Grewal
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Stimuli-induced NOergic Molecules and Neuropeptides Mediated Axon Reflexes Contribute to Tracers along Meridian Pathways Curr. Topics Med. Chem. (IF 3.4) Pub Date : 2024-01-18 Shengxing Ma
An abundance of studies from different international groups have demonstrated tracers along linear pathways resembling meridians over the body surface of humans. All experiments of the studies have been conducted by injection of a radiotracer solution or tracer dyes in a volume of solution into acupuncture points (acupoints). The solution injected into acupoints produces much stronger mechanical stimuli
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Current Status of Hedgehog Signaling Inhibitors Curr. Topics Med. Chem. (IF 3.4) Pub Date : 2024-01-17 Xiaotang Wang, Tian Wang, Xiaona Song, Jiping Gao, Guoqiang Xu, Yunhui Ma, Guohua Song
: The Hedgehog (Hh) signaling pathway plays a crucial role in diverse biological pro-cesses such as cell differentiation, proliferation, senescence, tumorigenesis, malignant transfor-mation, and drug resistance. Aberrant Hh signaling, resulting from mutations and excessive acti-vation, can contribute to the development of various diseases during different stages of biogenesis and development. Moreover
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Pharmacological Effects of FTY720 and its Derivatives Curr. Topics Med. Chem. (IF 3.4) Pub Date : 2024-01-05 Mengyuan Han, Xiangran Liu, Sendaer Hailati, Nulibiya Maihemuti, Nurbiya Nurahmat, Dilihuma Dilimulati, Alhar baishan, Alifeiye Aikebaier, Wenting Zhou, Yan Pan
FTY720 is an analog of sphingosine-1-phosphate (S1P) derived from the ascomycete Cordyceps sinensis. As a new immunosuppressant, FTY720 is widely used to treat multiple sclerosis. FTY720 binds to the S1P receptor after phosphorylation, thereby exerting immunosuppressive effects. The nonphosphorylated form of FTY720 can induce cell apoptosis, enhance chemotherapy sensitivity, and inhibit tumor metastasis