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Low Versus High Blood Pressure Targets in Critically Ill and Surgical Patients: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Crit. Care Med. (IF 8.8) Pub Date : 2024-04-24 Filippo D'Amico, Alessandro Pruna, Zbigniew Putowski, Sara Dormio, Silvia Ajello, Anna Mara Scandroglio, Todd C Lee, Alberto Zangrillo, Giovanni Landoni
Hypotension is associated with adverse outcomes in critically ill and perioperative patients. However, these assumptions are supported by observational studies. This meta-analysis of randomized controlled trials aims to compare the impact of lower versus higher blood pressure targets on mortality.
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Association of Relative Dysglycemia With Hospital Mortality in Critically Ill Patients: A Retrospective Study. Crit. Care Med. (IF 8.8) Pub Date : 2024-04-24 Tomoya Okazaki, Tadanori Nabeshima, Takushi Santanda, Yuiko Hoshina, Yuki Kondo, Yu Yaegashi, Taichi Nakazawa, Yasuharu Tokuda, Yasuhiro Norisue
Relative dysglycemia has been proposed as a clinical entity among critically ill patients in the ICU, but is not well studied. This study aimed to clarify associations of relative hyperglycemia and hypoglycemia during the first 24 hours after ICU admission with in-hospital mortality and the respective thresholds.
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Mortality Due to Acute Respiratory Distress Syndrome in Latin America. Crit. Care Med. (IF 8.8) Pub Date : 2024-04-18 Roberto Santa Cruz, Amelia Matesa, Antonella Gómez, Juan Nadur, Fernando Pagano, Daniel Prieto, Oswald Bolaños, Beatriz Solis, Sara Yusta, Edilzar González-Velásquez, Elisa Estenssoro, Alexandre Cavalcanti
Mortality due to acute respiratory distress syndrome (ARDS) is a major global health problem. Knowledge of epidemiological data on ARDS is crucial to design management, treatment strategies, and optimize resources. There is ample data regarding mortality of ARDS from high-income countries; in this review, we evaluated mortality due to ARDS in Latin America.
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Impact and Feasibility of Mechanical Ventilation at a Surgical Center in Sierra Leone: Experience From EMERGENCY's Hospital in Goderich. Crit. Care Med. (IF 8.8) Pub Date : 2024-04-15 Ornella Spagnolello, Richmond Dixon Cole, Jalloh Unisa, Hawa Vandi, Marian Macarthy, Sofia Gatti, Manuela Cormio, Gina Portella, Martina Baiardo Redaelli
Despite the large burden of critically ill patients in developing countries, mechanical ventilation (MV) is scarce in these low-resource settings. In the absence of data, issues like costs and lack of training are often felt to outweigh the benefits of potential MV implementation in such places. We aimed to investigate the impact and feasibility of MV in a surgical ICU in West Africa.
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Sleep and Circadian Health of Critical Survivors: A 12-Month Follow-Up Study. Crit. Care Med. (IF 8.8) Pub Date : 2024-04-10 Mario Henríquez-Beltrán, Rafaela Vaca, Iván D Benítez, Jessica González, Sally Santisteve, Maria Aguilà, Olga Minguez, Anna Moncusí-Moix, Clara Gort-Paniello, Gerard Torres, Gonzalo Labarca, Jesús Caballero, Carme Barberà, Antoni Torres, David de Gonzalo-Calvo, Ferran Barbé, Adriano D S Targa
To investigate the sleep and circadian health of critical survivors 12 months after hospital discharge and to evaluate a possible effect of the severity of the disease within this context.
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One-Year Recovery Among Survivors of Prolonged Severe COVID-19: A National Multicenter Cohort. Crit. Care Med. (IF 8.8) Pub Date : 2024-04-10 Anil N Makam, Judith Burnfield, Ed Prettyman, Oanh Kieu Nguyen, Nancy Wu, Edie Espejo, Cinthia Blat, W John Boscardin, E Wesley Ely, James C Jackson, Kenneth E Covinsky, John Votto
Understanding the long-term effects of severe COVID-19 illness on survivors is essential for effective pandemic recovery planning. Therefore, we investigated impairments among hospitalized adults discharged to long-term acute care hospitals (LTACHs) for prolonged severe COVID-19 illness who survived 1 year.
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Visualization of Cerebral Pressure Autoregulatory Insults in Traumatic Brain Injury. Crit. Care Med. (IF 8.8) Pub Date : 2024-04-08 Teodor Svedung Wettervik, Erta Beqiri, Anders Hånell, Stefan Yu Bögli, Michal Placek, Joseph Donnelly, Mathew R Guilfoyle, Adel Helmy, Andrea Lavinio, Peter J Hutchinson, Peter Smielewski
The first aim was to investigate the combined effect of insult intensity and duration of the pressure reactivity index (PRx) and deviation from the autoregulatory cerebral perfusion pressure target (∆CPPopt = actual CPP - optimal CPP [CPPopt]) on outcome in traumatic brain injury. The second aim was to determine if PRx influenced the association between intracranial pressure (ICP), CPP, and ∆CPPopt
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An Approach to Diversifying the Selection of a Guideline Panel-The Process Utilized for the Updated Adult Critical Care Ultrasound Guidelines. Crit. Care Med. (IF 8.8) Pub Date : 2024-04-08 Sara Nikravan, Michael J Lanspa, Enyo Ablordeppey, Anthony T Gerlach, Lori Shutter, Hariyali Patel, Karin Reuter-Rice, Kim Lewis, Sameer Sharif, José L Díaz-Gómez
Clinical practice guidelines are essential for promoting evidence-based healthcare. While diversification of panel members can reduce disparities in care, processes for panel selection lack transparency. We aim to share our approach in forming a diverse expert panel for the updated Adult Critical Care Ultrasound Guidelines.
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Anaerobic Lactate Production Is Associated With Decreased Microcirculatory Blood Flow and Decreased Mitochondrial Respiration Following Cardiovascular Surgery With Cardiopulmonary Bypass. Crit. Care Med. (IF 8.8) Pub Date : 2024-04-05 John C Greenwood, Fatima M Talebi, David H Jang, Audrey E Spelde, Emily K Gordon, Jiri Horak, Michael A Acker, Todd J Kilbaugh, Frances S Shofer, John G T Augoustides, Jacob S Brenner, Vladimir R Muzykantov, Jan Bakker, Benjamin S Abella
Quantify the relationship between perioperative anaerobic lactate production, microcirculatory blood flow, and mitochondrial respiration in patients after cardiovascular surgery with cardiopulmonary bypass.
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Evaluating the Sum of Eye and Motor Components of the Glasgow Coma Score As a Predictor of Extubation Failure in Patients With Acute Brain Injury. Crit. Care Med. (IF 8.8) Pub Date : 2024-04-01 Shaurya Taran, Bastien Perrot, Federico Angriman, Raphael Cinotti
To evaluate the association between the pre-extubation sum of eye and motor components of the Glasgow Coma Score (GCS-EM) and odds of extubation failure in patients with acute brain injury being liberated from mechanical ventilation.
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Quantifying the Impact of Alternative Definitions of Sepsis-Associated Acute Kidney Injury on its Incidence and Outcomes: A Systematic Review and Meta-Analysis. Crit. Care Med. (IF 8.8) Pub Date : 2024-04-01 Lachlan H Donaldson, Ruan Vlok, Ken Sakurai, Morgan Burrows, Gabrielle McDonald, Karthik Venkatesh, Sean M Bagshaw, Rinaldo Bellomo, Anthony Delaney, John Myburgh, Naomi E Hammond, Balasubramanian Venkatesh
To derive a pooled estimate of the incidence and outcomes of sepsis-associated acute kidney injury (SA-AKI) in ICU patients and to explore the impact of differing definitions of SA-AKI on these estimates.
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Clinical Efficacy of Beta-1 Selective Beta-Blockers Versus Propranolol in Patients With Thyroid Storm: A Retrospective Cohort Study. Crit. Care Med. (IF 8.8) Pub Date : 2024-03-29 Yuichiro Matsuo, Taisuke Jo, Hideaki Watanabe, Hiroki Matsui, Kiyohide Fushimi, Hideo Yasunaga
Thyroid storm is the most severe manifestation of thyrotoxicosis. Beta-blockers are among the standard treatment regimens for this condition, with propranolol being the historically preferred option. However, 2016 guidelines issued by the Japan Thyroid Association and the Japan Endocrine Society recommend the use of beta-1 selective beta-blockers over nonselective beta-blockers, such as propranolol
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Survival of Critically Ill COVID-19 Patients in Sweden During the First Two and a Half Years of the Pandemic. Crit. Care Med. (IF 8.8) Pub Date : 2024-03-28 Ailiana Santosa, Jonatan Oras, Huiqi Li, Chioma Nwaru, Brian Kirui, Fredrik Nyberg
Some studies have examined survival trends among critically ill COVID-19 patients, but most were case reports, small cohorts, and had relatively short follow-up periods. We aimed to examine the survival trend among critically ill COVID-19 patients during the first two and a half years of the pandemic and investigate potential predictors across different variants of concern periods.
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Machine Learning Identifies Higher Survival Profile In Extracorporeal Cardiopulmonary Resuscitation. Crit. Care Med. (IF 8.8) Pub Date : 2024-03-27 Ruben Crespo-Diaz, Julian Wolfson, Demetris Yannopoulos, Jason A Bartos
Extracorporeal cardiopulmonary resuscitation (ECPR) has been shown to improve neurologically favorable survival in patients with refractory out-of-hospital cardiac arrest (OHCA) caused by shockable rhythms. Further refinement of patient selection is needed to focus this resource-intensive therapy on those patients likely to benefit. This study sought to create a selection model using machine learning
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Pragmatic Approach to In Situ Simulation to Identify Latent Safety Threats Before Moving to a Newly Built ICU. Crit. Care Med. (IF 8.8) Pub Date : 2024-03-27 Aarti Sarwal, Nicholas A Morris, Janet Crumpler, Terri Gordon, Ian Saunders, James E Johnson, Jeff E Carter
Transitions to new care environments may have unexpected consequences that threaten patient safety. We undertook a quality improvement project using in situ simulation to learn the new patient care environment and expose latent safety threats before transitioning patients to a newly built adult ICU.
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Validation of Adult Sepsis Event and Epidemiologic Analysis of Sepsis Prevalence and Mortality Using Adult Sepsis Event's Electronic Health Records-Based Sequential Organ Failure Assessment Criteria: A Single-Center Study in South Korea. Crit. Care Med. (IF 8.8) Pub Date : 2024-03-26 Su Yeon Lee, Mi Hyeon Park, Dong Kyu Oh, Chae-Man Lim
In 2018, the Centers for Disease Control and Prevention introduced the Adult Sepsis Event (ASE) definition, using electronic health records (EHRs) data for surveillance and sepsis quality improvement. However, data regarding ASE outside the United States remain limited. We therefore aimed to validate the diagnostic accuracy of the ASE and to assess the prevalence and mortality of sepsis using ASE.
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A Randomized Noninferiority Trial to Compare Enteral to Parenteral Phosphate Replacement on Biochemistry, Waste, and Environmental Impact and Healthcare Cost in Critically Ill Patients With Mild to Moderate Hypophosphatemia. Crit. Care Med. (IF 8.8) Pub Date : 2024-03-25 Chinh D Nguyen, Haustine P Panganiban, Timothy Fazio, Amalia Karahalios, Melissa Akravs, Christopher M MacIsaac, Thomas Rechnitzer, Lucy Arno, An Tran-Duy, Scott McAlister, Yasmine Ali Abdelhamid, Adam M Deane
Hypophosphatemia occurs frequently. Enteral, rather than IV, phosphate replacement may reduce fluid replacement, cost, and waste.
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Measures and Impact of Caseload Surge During the COVID-19 Pandemic: A Systematic Review. Crit. Care Med. (IF 8.8) Pub Date : 2024-03-22 Maniraj Neupane, Nathaniel De Jonge, Sahil Angelo, Sadia Sarzynski, Junfeng Sun, Bram Rochwerg, John Hick, Steven H Mitchell, Sarah Warner, Alex Mancera, Diane Cooper, Sameer S Kadri
COVID-19 pandemic surges strained hospitals globally. We performed a systematic review to examine measures of pandemic caseload surge and its impact on mortality of hospitalized patients.
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Analgesia and Sedation Use During Noninvasive Ventilation for Acute Respiratory Failure. Crit. Care Med. (IF 8.8) Pub Date : 2024-03-20 Peter J Dunbar, Ryan Peterson, Max McGrath, Raymond Pomponio, Tyree H Kiser, P Michael Ho, R William Vandivier, Ellen L Burnham, Marc Moss, Peter D Sottile
To describe U.S. practice regarding administration of sedation and analgesia to patients on noninvasive ventilation (NIV) for acute respiratory failure (ARF) and to determine the association of this practice with odds of intubation or death.
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The Efficacy of Low-Titer Group O Whole Blood Compared With Component Therapy in Civilian Trauma Patients: A Meta-Analysis. Crit. Care Med. (IF 8.8) Pub Date : 2024-03-14 Katrina M Morgan, Elissa Abou Khalil, Erin V Feeney, Philip C Spinella, Amelia C Lucisano, Barbara A Gaines, Christine M Leeper
To assess if transfusion with low-titer group O whole blood (LTOWB) is associated with improved early and/or late survival compared with component blood product therapy (CT) in bleeding trauma patients.
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Extracorporeal Versus Conventional Cardiopulmonary Resuscitation for In-Hospital Cardiac Arrest: A Propensity Score Matching Cohort Study. Crit. Care Med. (IF 8.8) Pub Date : 2024-03-05 Yuan Bian, Yuhui Pan, Jiaqi Zheng, Wen Zheng, Lijie Qin, Guangju Zhou, Xifeng Sun, Mingjie Wang, Chunyi Wang, Yuguo Chen, Feng Xu
Comparing the effects of extracorporeal cardiopulmonary resuscitation (ECPR) and conventional cardiopulmonary resuscitation (CCPR) on outcomes in patients with in-hospital cardiac arrest (IHCA) in China. The benefits of ECPR over CCPR in patients with IHCA remain controversial.
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Impact of Lactate Clearance on Clinical and Neurological Outcomes of Patients With Out-of-Hospital Cardiac Arrest Treated With Extracorporeal Cardiopulmonary Resuscitation: A Secondary Data Analysis. Crit. Care Med. (IF 8.8) Pub Date : 2024-02-27 Momoko Sugimoto, Wataru Takayama, Akihiko Inoue, Toru Hifumi, Tetsuya Sakamoto, Yasuhiro Kuroda, Yasuhiro Otomo
Serial evaluations of lactate concentration may be more useful in predicting outcomes in patients with out-of-hospital cardiac arrest (OHCA) than a single measurement. This study aimed to evaluate the impact of lactate clearance (LC) on clinical and neurologic outcomes in patients with OHCA who underwent extracorporeal cardiopulmonary resuscitation (ECPR).
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Toward Equitable Kidney Function Estimation in Critical Care Practice. Guidance From the Society of Critical Care Medicine's Diversity, Equity, and Inclusion in Renal Clinical Practice Task Force. Crit. Care Med. (IF 8.8) Pub Date : 2024-02-26 Todd A Miano, Erin F Barreto, Molly McNett, Niels Martin, Ankit Sakhuja, Adair Andrews, Rajit K Basu, Enyo Ama Ablordeppey
Accurate glomerular filtration rate (GFR) assessment is essential in critically ill patients. GFR is often estimated using creatinine-based equations, which require surrogates for muscle mass such as age and sex. Race has also been included in GFR equations, based on the assumption that Black individuals have genetically determined higher muscle mass. However, race-based GFR estimation has been questioned
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Real-World Implications of Updated Surviving Sepsis Campaign Antibiotic Timing Recommendations. Crit. Care Med. (IF 8.8) Pub Date : 2024-02-22 Stephanie P Taylor, Marc A Kowalkowski, Sable Skewes, Shih-Hsiung Chou
To evaluate real-world implications of updated Surviving Sepsis Campaign (SSC) recommendations for antibiotic timing.
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Real-Time Machine Learning Alerts to Prevent Escalation of Care: A Nonrandomized Clustered Pragmatic Clinical Trial. Crit. Care Med. (IF 8.8) Pub Date : 2024-02-21 Matthew A Levin, Arash Kia, Prem Timsina, Fu-Yuan Cheng, Kim-Anh-Nhi Nguyen, Roopa Kohli-Seth, Hung-Mo Lin, Yuxia Ouyang, Robert Freeman, David L Reich
Machine learning algorithms can outperform older methods in predicting clinical deterioration, but rigorous prospective data on their real-world efficacy are limited. We hypothesized that real-time machine learning generated alerts sent directly to front-line providers would reduce escalations.
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Barriers and Facilitators to End-of-Life Care Delivery in ICUs: A Qualitative Study. Crit. Care Med. (IF 8.8) Pub Date : 2024-02-19 Lauren M Janczewski, Adithya Chandrasekaran, Egide Abahuje, Bona Ko, John D Slocum, Kaithlyn Tesorero, My L T Nguyen, Sohae Yang, Erin A Strong, Kunjan Bhakta, Jeffrey P Huml, Jacqueline M Kruser, Julie K Johnson, Anne M Stey
To understand frontline ICU clinician's perceptions of end-of-life care delivery in the ICU.
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Comparison of Different Treatments of Persistent Pulmonary Hypertension of the Newborn: A Systematic Review and Network Meta-Analysis. Crit. Care Med. (IF 8.8) Pub Date : 2024-02-16 Qiang Fei, Jiarong Pan, Feizhou Zhang, Yu Lin, Tianming Yuan
Persistent pulmonary hypertension of the newborn (PPHN) is a life-threatening disease. Despite being considered the gold standard treatment scheme, inhaled nitric oxide (iNO) is not readily available in settings with limited resources. Therefore, in recent years, research on related drugs is being actively pursued. Herein, we aimed to use random-effects network meta-analysis to evaluate the efficacy
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Evolution of Clinical Characteristics and Outcomes of Critically Ill Patients 90 Years Old or Older Over a 12-Year Period: A Retrospective Cohort Study. Crit. Care Med. (IF 8.8) Pub Date : 2024-02-15 Rikus Daniels, Jakob Müller, Claudia Jafari, Pauline Theile, Stefan Kluge, Kevin Roedl
The global population is aging, and the proportion of very elderly patients 90 years old or older in the ICU is expected to increase. The changes in the comorbidities and outcomes of very elderly patients hospitalized in the ICU that have occurred over time are unknown.
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Fixed- Versus Variable-Dose Prothrombin Complex Concentrate for the Emergent Reversal of Vitamin K Antagonists: A Systematic Review and Meta-Analysis. Crit. Care Med. (IF 8.8) Pub Date : 2024-02-14 Amr Alwakeal, Matthew B Maas, Andrew M Naidech, Babak S Jahromi, Matthew B Potts
Four-factor prothrombin complex concentrate (4-PCC) is recommended for rapid reversal of vitamin K antagonists (VKAs) such as warfarin, yet optimal dosing remains uncertain.
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Factors Affecting Mortality in Critically Ill Patients With Tuberculosis: A Systematic Review and Meta-Analysis. Crit. Care Med. (IF 8.8) Pub Date : 2024-02-12 Shivangi Mishra, Jinay Gala, Jose Chacko
Critically ill patients with tuberculosis carry high mortality. Identification of factors associated with mortality in critically ill tuberculosis patients may enable focused treatment.
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Current Use and Impact of Pulmonary Artery Catheters on the Short-Term Outcomes in Patients With Cardiogenic Shock Treated With an Impella: Findings From the Japan Registry for Percutaneous Ventricular Assist Device (J-PVAD). Crit. Care Med. (IF 8.8) Pub Date : 2024-02-09 Riku Arai, Nobuhiro Murata, Daisuke Fukamachi, Yasuo Okumura
This study aimed to investigate the current use and impact of pulmonary artery catheters (PACs) in patients with cardiogenic shock (CS) who underwent Impella support.
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Early Mobilization Using a Mobile Patient Lift in the ICU: A Randomized Controlled Trial. Crit. Care Med. (IF 8.8) Pub Date : 2024-02-06 Ginga Suzuki, Hiromi Kanayama, Yoshiaki Arai, Yuji Iwanami, Toshimitsu Kobori, Yuka Masuyama, Saki Yamamoto, Hibiki Serizawa, Yoshimi Nakamichi, Masayuki Watanabe, Mitsuru Honda, Ikuko Okuni
To ascertain whether a mobile patient lift facilitates early mobilization in ventilated ICU patients.
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Associations Between Family-Assessed Quality-of-Dying-and-Death Latent Classes and Bereavement Outcomes for Family Surrogates of ICU Decedents. Crit. Care Med. (IF 8.8) Pub Date : 2024-02-01 Fur-Hsing Wen, Holly G Prigerson, Tsung-Hui Hu, Chung-Chi Huang, Wen-Chi Chou, Li-Pang Chuang, Ming Chu Chiang, Siew Tzuh Tang
To examine associations between family surrogates' bereavement outcomes and four previously determined quality of dying and death (QODD) latent classes (high, moderate, poor-to-uncertain, and worst).
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Effect of Increasing Blood Pressure on Brain Tissue Oxygenation in Adults After Severe Traumatic Brain Injury. Crit. Care Med. (IF 8.8) Pub Date : 2024-02-01 Thitikan Kunapaisal, Abhijit V Lele, Courtney Gomez, Anne Moore, Marie Angele Theard, Monica S Vavilala
To examine if increasing blood pressure improves brain tissue oxygenation (PbtO2) in adults with severe traumatic brain injury (TBI).
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Effects of Vibration Therapy on the Physical Function of Critically Ill Adults Trial: A Randomized Controlled Trial. Crit. Care Med. (IF 8.8) Pub Date : 2024-01-26 Satoshi Doi, Nobuto Nakanishi, Yoshimi Kawahara, Keiko Nomura, Mamiko Shima, Mie Shiraishi, Jun Oto
Vibration therapy uses vibration to rehabilitate physical functions. Recently, it has been demonstrated to be safe for critically ill patients. However, its effects on physical functions are unclear.
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Treatment Fidelity in 94 Randomized Controlled Trials of Physical Rehabilitation in the ICU: A Scoping Review. Crit. Care Med. (IF 8.8) Pub Date : 2024-01-24 Christopher Farley, Anastasia N L Newman, Jen Hoogenes, Dina Brooks, Mark Duffett, Michelle E Kho
Recent reviews demonstrated discordant effects of ICU-based physical rehabilitation on physical function. These inconsistencies may be related to differences in treatment fidelity-the extent to which a protocol is delivered as planned. Before evaluating the association of fidelity with outcomes, we must first understand the extent of treatment fidelity reporting in ICU-based physical rehabilitation
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A Nationwide, Prospective Study of Tracheal Intubation in Critically Ill Adults in Spain: Management, Associated Complications, and Outcomes. Crit. Care Med. (IF 8.8) Pub Date : 2024-01-23 José Garnacho-Montero, Elena Gordillo-Escobar, Josep Trenado, Federico Gordo, Lourdes Fisac, Emilio García-Prieto, Cristina López-Martin, Ana Abella, Juan Ramón Jiménez, José Luis García-Garmendia
Our aims were to explore current intubation practices in Spanish ICUs to determine the incidence and risk factors of peri-intubation complications (primary outcome measure: major adverse events), the rate and factors associated with first-pass success, and their impact on mortality as well as the changes of the intubation procedure observed in the COVID-19 pandemic.
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Society of Critical Care Medicine Guidelines on Glycemic Control for Critically Ill Children and Adults 2024. Crit. Care Med. (IF 8.8) Pub Date : 2024-01-19 Kimia Honarmand, Michael Sirimaturos, Eliotte L Hirshberg, Nicholas G Bircher, Michael S D Agus, David L Carpenter, Claudia R Downs, Elizabeth A Farrington, Amado X Freire, Amanda Grow, Sharon Y Irving, James S Krinsley, Michael J Lanspa, Micah T Long, David Nagpal, Jean-Charles Preiser, Vijay Srinivasan, Guillermo E Umpierrez, Judith Jacobi
Maintaining glycemic control of critically ill patients may impact outcomes such as survival, infection, and neuromuscular recovery, but there is equipoise on the target blood levels, monitoring frequency, and methods.
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Management of Heat-Related Illness and Injury in the Intensive Care Unit: A Concise Definitive Review. Crit. Care Med. (IF 8.8) Pub Date : 2024-01-19 Jeffrey F Barletta, Tina L Palmieri, Shari A Toomey, Christopher G Harrod, Srinivas Murthy, Heatherlee Bailey
The increasing frequency of extreme heat events has led to a growing number of heat-related injuries and illnesses in ICUs. The objective of this review was to summarize and critically appraise evidence for the management of heat-related illnesses and injuries for critical care multiprofessionals.
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2024 Focused Update: Guidelines on Use of Corticosteroids in Sepsis, Acute Respiratory Distress Syndrome, and Community-Acquired Pneumonia. Crit. Care Med. (IF 8.8) Pub Date : 2024-01-19 Dipayan Chaudhuri, Andrea M Nei, Bram Rochwerg, Robert A Balk, Karim Asehnoune, Rhonda Cadena, Joseph A Carcillo, Ricardo Correa, Katherine Drover, Annette M Esper, Hayley B Gershengorn, Naomi E Hammond, Namita Jayaprakash, Kusum Menon, Lama Nazer, Tyler Pitre, Zaffer A Qasim, James A Russell, Ariel P Santos, Aarti Sarwal, Joanna Spencer-Segal, Nejla Tilouche, Djillali Annane, Stephen M Pastores
New evidence is available examining the use of corticosteroids in sepsis, acute respiratory distress syndrome (ARDS) and community-acquired pneumonia (CAP), warranting a focused update of the 2017 guideline on critical illness-related corticosteroid insufficiency.
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Position Paper on the Reporting of Norepinephrine Formulations in Critical Care from the Society of Critical Care Medicine and European Society of Intensive Care Medicine Joint Task Force. Crit. Care Med. (IF 8.8) Pub Date : 2024-01-19 Patrick M Wieruszewski, Marc Leone, Benjamin Skov Kaas-Hansen, Siddharth Dugar, Matthieu Legrand, Cathrine A McKenzie, Brittany D Bissell Turpin, Antonio Messina, Prashant Nasa, Christa A Schorr, Jan J De Waele, Ashish K Khanna
To provide guidance on the reporting of norepinephrine formulation labeling, reporting in publications, and use in clinical practice.
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Survival for Nonshockable Cardiac Arrests Treated With Noninvasive Circulatory Adjuncts and Head/Thorax Elevation. Crit. Care Med. (IF 8.8) Pub Date : 2024-01-19 Kerry M Bachista, Johanna C Moore, José Labarère, Remle P Crowe, Lauren D Emanuelson, Charles J Lick, Guillaume P Debaty, Joseph E Holley, Ryan P Quinn, Kenneth A Scheppke, Paul E Pepe
Cardiac arrests remain a leading cause of death worldwide. Most patients have nonshockable electrocardiographic presentations (asystole/pulseless electrical activity). Despite well-performed basic and advanced cardiopulmonary resuscitation (CPR) interventions, patients with these presentations have always faced unlikely chances of survival. The primary objective was to determine if, in addition to
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Timely Cessation of Proton Pump Inhibitors in Critically Ill Patients Impacts Morbidity and Mortality: A Propensity Score-Matched Cohort Study. Crit. Care Med. (IF 8.8) Pub Date : 2024-01-19 Lars Palmowski, Alexander von Busch, Matthias Unterberg, Lars Bergmann, Stefanie Schmitz, Andreas Schlüter, Jürgen Peters, Michael Adamzik, Tim Rahmel
Proton pump inhibitors (PPIs) are among the drugs most commonly used in critically ill patients. Although mainly applied temporarily for stress ulcer prophylaxis, their application is frequently not terminated. Potential adverse effects of PPI treatment could impact the outcome in case of unnecessary and, therefore, avoidable long-term continuation. We tested the hypotheses that nonindicated PPI therapy
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Defining Intensivists: A Retrospective Analysis of the Published Studies in the United States, 2010-2020. Crit. Care Med. (IF 8.8) Pub Date : 2024-01-19 Neil A Halpern, Kay See Tan, Lilly A Bothwell, Lindsay Boyce, Alina O Dulu
The Society of Critical Care Medicine last published an intensivist definition in 1992. Subsequently, there have been many publications relating to intensivists. Our purpose is to assess how contemporary studies define intensivist physicians.
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Surviving Sepsis Campaign Research Priorities 2023. Crit. Care Med. (IF 8.8) Pub Date : 2024-01-19 Daniel De Backer, Clifford S Deutschman, Judith Hellman, Sheila Nainan Myatra, Marlies Ostermann, Hallie C Prescott, Daniel Talmor, Massimo Antonelli, Luciano Cesar Pontes Azevedo, Seth R Bauer, Niranjan Kissoon, Ignacio-Martin Loeches, Mark Nunnally, Pierre Tissieres, Antoine Vieillard-Baron, Craig M Coopersmith
To identify research priorities in the management, epidemiology, outcome, and pathophysiology of sepsis and septic shock.
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Executive Summary: Society of Critical Care Medicine Guidelines on Recognizing and Responding to Clinical Deterioration Outside the ICU. Crit. Care Med. (IF 8.8) Pub Date : 2024-01-19 Kimia Honarmand, Randy S Wax, Daleen Penoyer, Geoffery Lighthall, Valerie Danesh, Bram Rochwerg, Michael L Cheatham, Daniel P Davis, Michael DeVita, James Downar, Dana Edelson, Alison Fox-Robichaud, Shigeki Fujitani, Raeann M Fuller, Helen Haskell, Matthew Inada-Kim, Daryl Jones, Anand Kumar, Keith M Olsen, Daniel D Rowley, John Welch, Marie R Baldisseri, John Kellett, Heidi Knowles, Jonathan K Shipley
Clinical deterioration of patients hospitalized outside the ICU is a source of potentially reversible morbidity and mortality. To address this, some acute care facilities have implemented systems aimed at detecting and responding to such patients.
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Society of Critical Care Medicine Guidelines on Recognizing and Responding to Clinical Deterioration Outside the ICU: 2023. Crit. Care Med. (IF 8.8) Pub Date : 2024-01-19 Kimia Honarmand, Randy S Wax, Daleen Penoyer, Geoffery Lighthall, Valerie Danesh, Bram Rochwerg, Michael L Cheatham, Daniel P Davis, Michael DeVita, James Downar, Dana Edelson, Alison Fox-Robichaud, Shigeki Fujitani, Raeann M Fuller, Helen Haskell, Matthew Inada-Kim, Daryl Jones, Anand Kumar, Keith M Olsen, Daniel D Rowley, John Welch, Marie R Baldisseri, John Kellett, Heidi Knowles, Jonathan K Shipley
Clinical deterioration of patients hospitalized outside the ICU is a source of potentially reversible morbidity and mortality. To address this, some acute care hospitals have implemented systems aimed at detecting and responding to such patients.
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Concise Definitive Review: In-Hospital Violence and Its Impact on Critical Care Practitioners. Crit. Care Med. (IF 8.8) Pub Date : 2024-01-18 Gary A Bass, Cherylee W J Chang, Julie M Winkle, Maurizio Cecconi, Sapna R Kudchadkar, Kwame Akuamoah-Boateng, Sharon Einav, Caoimhe C Duffy, Jorge Hidalgo, Gloria M Rodriquez-Vega, Antonio J Gandra-d'Almeida, Jeffrey F Barletta, Lewis J Kaplan
To provide a narrative review of hospital violence (HV) and its impact on critical care clinicians.
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Robotic-Assisted In-Bed Mobilization in Ventilated ICU Patients With COVID-19: An Interventional, Randomized, Controlled Pilot Study (ROBEM II Study). Crit. Care Med. (IF 8.8) Pub Date : 2024-01-18 Marco Lorenz, Felix Baum, Philipp Kloss, Nadine Langer, Vanessa Arsene, Linus Warner, Alessandro Panelli, Frederike V Hartmann, Kristina Fuest, Julius J Grunow, Philipp Enghard, Stefan J Schaller
The COVID-19 pandemic significantly impacted global healthcare systems, particularly in managing critically ill mechanically ventilated patients. This study aims to assess the feasibility of robotic-assisted mobilization in COVID-19 patients.
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Flow-Limited and Reverse-Triggered Ventilator Dyssynchrony Are Associated With Increased Tidal and Dynamic Transpulmonary Pressure. Crit. Care Med. (IF 8.8) Pub Date : 2024-01-12 Peter D Sottile, Bradford Smith, Jake N Stroh, David J Albers, Marc Moss
Ventilator dyssynchrony may be associated with increased delivered tidal volumes (Vts) and dynamic transpulmonary pressure (ΔPL,dyn), surrogate markers of lung stress and strain, despite low Vt ventilation. However, it is unknown which types of ventilator dyssynchrony are most likely to increase these metrics or if specific ventilation or sedation strategies can mitigate this potential.
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Sodium and Its Impact on Outcome After Aneurysmal Subarachnoid Hemorrhage in Patients With and Without Delayed Cerebral Ischemia. Crit. Care Med. (IF 8.8) Pub Date : 2024-01-11 Homeyra Labib, Maud A Tjerkstra, Bert A Coert, René Post, W Peter Vandertop, Dagmar Verbaan, Marcella C A Müller
To perform a detailed examination of sodium levels, hyponatremia and sodium fluctuations, and their association with delayed cerebral ischemia (DCI) and poor outcome after aneurysmal subarachnoid hemorrhage (aSAH).
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Clinical Impact of the Implementation Strategies Used to Apply the 2013 Pain, Agitation/Sedation, Delirium or 2018 Pain, Agitation/Sedation, Delirium, Immobility, Sleep Disruption Guideline Recommendations: A Systematic Review and Meta-Analysis. Crit. Care Med. (IF 8.8) Pub Date : 2024-01-09 Nicole E Hume, Isabelle Zerfas, Adrian Wong, Michele Klein-Fedyshin, Pamela L Smithburger, Mitchell S Buckley, John W Devlin, Sandra L Kane-Gill
To summarize the effectiveness of implementation strategies for ICU execution of recommendations from the 2013 Pain, Agitation/Sedation, Delirium (PAD) or 2018 PAD, Immobility, Sleep Disruption (PADIS) guidelines.
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Recovery Trajectories in Children Requiring 3 or More Days of Invasive Ventilation. Crit. Care Med. (IF 8.8) Pub Date : 2024-01-09 Aline B Maddux, Kristen R Miller, Yamila L Sierra, Tellen D Bennett, R Scott Watson, Matthew Spear, Laura L Pyle, Peter M Mourani
To characterize health-related quality of life (HRQL) and functional recovery trajectories and risk factors for prolonged impairments among critically ill children receiving greater than or equal to 3 days of invasive ventilation.
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Moderate Exercise Modulates Inflammatory Responses and Improves Survival in a Murine Model of Acute Pneumonia. Crit. Care Med. (IF 8.8) Pub Date : 2024-01-09 Veronique Vermeersch, Karelle Léon, Anais Caillard, Amandine Szczesnowski, Gaëlle Albacete, Nadege Marec, Florine Tissier, Guillaume Gilbert, Mickael Droguet, Pascale Marcorelles, Marie-Agnes Giroux-Metges, Olivier Huet
An association between physical inactivity and worse outcome during infectious disease has been reported. The effect of moderate exercise preconditioning on the immune response during an acute pneumonia in a murine model was evaluated.
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Left-Ventricular Unloading With Impella During Refractory Cardiac Arrest Treated With Extracorporeal Cardiopulmonary Resuscitation: A Systematic Review and Meta-Analysis. Crit. Care Med. (IF 8.8) Pub Date : 2024-01-05 Tharusan Thevathasan, Lisa Füreder, Marie Fechtner, Sivagowry Rasalingam Mørk, Benedikt Schrage, Dirk Westermann, Louise Linde, Emilie Gregers, Jo Bønding Andreasen, Christopher Gaisendrees, Takashi Unoki, Andrea L Axtell, Koji Takeda, Alice V Vinogradsky, Pedro Gonçalves-Teixeira, Anthony Lemaire, Marta Alonso-Fernandez-Gatta, Hoong Sern Lim, Arthur Reshad Garan, Amarinder Bindra, Gary Schwartz, Ulf
Extracorporeal cardiopulmonary resuscitation (ECPR) is the implementation of venoarterial extracorporeal membrane oxygenation (VA-ECMO) during refractory cardiac arrest. The role of left-ventricular (LV) unloading with Impella in addition to VA-ECMO ("ECMELLA") remains unclear during ECPR. This is the first systematic review and meta-analysis to characterize patients with ECPR receiving LV unloading
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Perspectives of ICU Patients on Deferred Consent in the Context of Post-ICU Quality of Life: A Substudy of a Randomized Clinical Trial. Crit. Care Med. (IF 8.8) Pub Date : 2024-01-05 L Imeen van der Wal, Chloe C A Grim, Michael R Del Prado, David J van Westerloo, Marcus J Schultz, Hendrik J F Helmerhorst, Martine C de Vries, Evert de Jonge
Deferred consent enables research to be conducted in the ICU when patients are unable to provide consent themselves, and there is insufficient time to obtain consent from surrogates before commencing (trial) treatment. The aim of this study was to evaluate how former ICU patients reflect on their participation in a study with deferred consent and examine whether their opinions are influenced by the
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Cerebral Oximetry During Pediatric In-Hospital Cardiac Arrest: A Multicenter Study of Survival and Neurologic Outcome. Crit. Care Med. (IF 8.8) Pub Date : 2024-01-05 Tia T Raymond, Ivie D Esangbedo, Prakadeshwari Rajapreyar, Sangmo Je, Xuemei Zhang, Heather M Griffis, Martin K Wakeham, Tara L Petersen, Matthew P Kirschen, Alexis A Topjian, Javier J Lasa, Conall I Francoeur, Vinay M Nadkarni
To determine if near-infrared spectroscopy measuring cerebral regional oxygen saturation (crSo2) during cardiopulmonary resuscitation is associated with return of spontaneous circulation (ROSC) and survival to hospital discharge (SHD) in children.
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Central Line-Associated Bloodstream Infection Misclassifications-Rethinking the Centers for Disease Control and Prevention's Central Line-Associated Bloodstream Infection Definition and Its Implications. Crit. Care Med. (IF 8.8) Pub Date : 2024-01-05 Madhuri M Sopirala, Carolee D Estelle, La'Titia Houston
Centers for Medicare and Medicaid Services imparts financial penalties for central line-associated bloodstream infections (CLABSIs) and other healthcare-acquired infections. Data for this purpose is obtained from the Centers for Disease Control and Prevention (CDC)'s National Health Safety Network. We present examples of misclassification of bloodstream infections into CLABSI by the CDC's definition
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Application of Cardiovascular Physiology to the Critically Ill Patient. Crit. Care Med. (IF 8.8) Pub Date : 2023-12-21 Ronald A Bronicki, Sebastian Tume, Hernando Gomez, Cameron Dezfulian, Daniel J Penny, Michael R Pinsky, Daniel Burkhoff
To use the ventricular pressure-volume relationship and time-varying elastance model to provide a foundation for understanding cardiovascular physiology and pathophysiology, interpreting advanced hemodynamic monitoring, and for illustrating the physiologic basis and hemodynamic effects of therapeutic interventions. We will build on this foundation by using a cardiovascular simulator to illustrate the
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External Validation of Deep Learning-Based Cardiac Arrest Risk Management System for Predicting In-Hospital Cardiac Arrest in Patients Admitted to General Wards Based on Rapid Response System Operating and Nonoperating Periods: A Single-Center Study. Crit. Care Med. (IF 8.8) Pub Date : 2023-12-20 Kyung-Jae Cho, Kwan Hyung Kim, Jaewoo Choi, Dongjoon Yoo, Jeongmin Kim
The limitations of current early warning scores have prompted the development of deep learning-based systems, such as deep learning-based cardiac arrest risk management systems (DeepCARS). Unfortunately, in South Korea, only two institutions operate 24-hour Rapid Response System (RRS), whereas most hospitals have part-time or no RRS coverage at all. This study validated the predictive performance of