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Personalized resuscitation using 3D transesophageal echocardiography Resuscitation (IF 6.5) Pub Date : 2024-04-23 Chia-Ching Chen, Diane Lee, Hung-Tsang Yen, Wan-Ching Lien
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Biomarkers for neuroprognostication after standard versus extracorporeal cardiopulmonary resuscitation – A sub-analysis of Prague-OHCA study Resuscitation (IF 6.5) Pub Date : 2024-04-20 Helena Brodska, Jana Smalcova, Petra Kavalkova, Danielle R. Lavage, Milan Dusik, Jan Belohlavek, Tomas Drabek
Limited evidence exists for prognostic performance of biomarkers in patients resuscitated from out-of-hospital cardiac arrest (OHCA) with extracorporeal CPR (ECPR). We hypothesized that (1) the time course and (2) prognostic performance of biomarkers might differ between CPR and ECPR in a sub-analysis of Prague-OHCA study. Patients received either CPR ( = 164) or ECPR ( = 92). The primary outcome was
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Evaluating the impact of ELSO guideline adherence on favorable neurological outcomes among patients requiring extracorporeal cardiopulmonary resuscitation for out-of-hospital cardiac arrest Resuscitation (IF 6.5) Pub Date : 2024-04-20 Akira Kawauchi, Yohei Okada, Makoto Aoki, Tomoko Ogasawara, Takashi Tagami, Nobuya Kitamura, Mitsunobu Nakamura, SOS-KANTO 2017 Study Group
Selecting the appropriate candidates for extracorporeal cardiopulmonary resuscitation (ECPR) for out-of-hospital cardiac arrest (OHCA) is challenging. Previously, the Extracorporeal Life Support Organization (ELSO) guidelines suggested the example of inclusion criteria. However, it is unclear whether patients who meet the inclusion criteria of the ELSO guidelines have more favorable outcomes. We aimed
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The association of recent simulation training and clinical experience of team leaders with cardiopulmonary resuscitation quality during in-hospital cardiac arrest Resuscitation (IF 6.5) Pub Date : 2024-04-20 Johannes Wittig, Bo Løfgren, Rasmus P Nielsen, Rikke Højbjerg, Kristian Krogh, Hans Kirkegaard, Robert A. Berg, Vinay M. Nadkarni, Kasper G Lauridsen
We aimed to investigate the association of recent team leader simulation training (<6 months) and years of clinical experience (≥4 years) with chest compression quality during in-hospital cardiac arrest (IHCA). This cohort study of IHCA in four Danish hospitals included cases with data on chest compression quality and team leader characteristics. We assessed the impact of recent simulation training
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Cerebral edema following cardiac arrest: Are all shades of gray equal? Resuscitation (IF 6.5) Pub Date : 2024-04-16 Rachel Beekman, Emily J. Gilmore
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CT brain perfusion patterns and clinical outcome after successful cardiopulmonary resuscitation: A pilot study Resuscitation (IF 6.5) Pub Date : 2024-04-16 Arsany Hakim, Mattia Branca, Christoph Kurmann, Benedikt Wagner, Manuela Iten, Matthias Hänggi, Franca Wagner
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Cardiac arrest: Treatment is prevention? Resuscitation (IF 6.5) Pub Date : 2024-04-16 Alexis Descatha, Dominique Savary
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Alternative defibrillation strategies: More answers and more questions Resuscitation (IF 6.5) Pub Date : 2024-04-11 Tommaso Scquizzato, Markus B. Skrifvars
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Norepinephrine or just more epinephrine: Which is the best vasopressor for post-arrest shock? Resuscitation (IF 6.5) Pub Date : 2024-04-10 Nicholas J. Johnson, Ari Moskowitz
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Organ donation after extracorporeal cardiopulmonary resuscitation for refractory out-of-hospital cardiac arrest in a metropolitan cardiac arrest centre in Milan, Italy Resuscitation (IF 6.5) Pub Date : 2024-04-10 Matteo Aldo Bonizzoni, Tommaso Scquizzato, Marina Pieri, Silvia Delrio, Pasquale Nardelli, Alessandro Ortalda, Antonio Dell'Acqua, Anna Mara Scandroglio, ECPR-CARE Collaborators, Otello Giancarlo Turla, Claudia Francescon, Andrea Gambirasio, Tommaso Scaglia
Extracorporeal cardiopulmonary resuscitation (ECPR) may improve survival in refractory out-of-hospital cardiac arrest (OHCA) but also expand the donor pool as these patients often become eligible for organ donation. Our aim is to describe the impact of organ donation in OHCA patients treated with ECPR in a high-volume cardiac arrest centre. Rate of organ donation (primary outcome), organs harvested
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Recalled experience of death: Disinhibition not degeneration in relation to death facilitates inner states of lucid hyperconsciousness with novel cognitive insights Resuscitation (IF 6.5) Pub Date : 2024-04-10 Sam Parnia, Jignesh Patel, Benjamin M. Bloom, Erik Kulstad, Charles D. Deakin, Rebecca Spiegel
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Recognizing the fastest growing cause of out-of-hospital cardiac arrest Resuscitation (IF 6.5) Pub Date : 2024-04-09 Aaron M. Orkin, Cameron Dezfulian
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Follow up of cardiac arrest survivors: Survey of French intensivists practices Resuscitation (IF 6.5) Pub Date : 2024-04-05 Marine Paul, Julie Paquereau, Stéphane Legriel, Alain Cariou
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Outcomes of a proactive first responder system for out-of-hospital cardiac arrests Resuscitation (IF 6.5) Pub Date : 2024-04-04 Adam J.R. Watson, Andrew Cumpstey, Jack Ansell, Martina Brown, Charles D. Deakin
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Good outcome prediction after out-of-hospital cardiac arrest: A prospective multicenter observational study in Korea (the KORHN-PRO registry) Resuscitation (IF 6.5) Pub Date : 2024-04-04 Hyo Jin Bang, Chun Song Youn, Claudio Sandroni, Kyu Nam Park, Byung Kook Lee, Sang Hoon Oh, In Soo Cho, Seung Pill Choi, on behalf of the Korean Hypothermia Network Investigators
To assess the ability of clinical examination, biomarkers, electrophysiology and brain imaging, individually or in combination to predict good neurological outcomes at 6 months after CA. This was a retrospective analysis of the Korean Hypothermia Network Prospective Registry 1.0, which included adult out-of-hospital cardiac arrest (OHCA) patients (≥18 years). Good outcome predictors were defined as
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A retrospective comparison of mechanical cardio-pulmonary ventilation and manual bag valve ventilation in non-traumatic out-of-hospital cardiac arrests: A study from the Belgian cardiac arrest registry Resuscitation (IF 6.5) Pub Date : 2024-04-04 Stefano Malinverni, Stéphan Wilmin, Diane de Longueville, Mathilde Sarnelli, Griet Vermeulen, Mahmoud Kaabour, Marc Van Nuffelen, Ives Hubloue, Simon Scheyltjens, Alessandro Manara, Pierre Mols, Jean-Christophe Richard, Francis Desmet
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Controlled donation after circulatory death in post-cardiac arrest patients: Estimates from a large registry Resuscitation (IF 6.5) Pub Date : 2024-04-04 Marie Renaudier, Yannick Binois, Florence Dumas, Lionel Lamhaut, Frankie Beganton, Daniel Jost, Julien Charpentier, Olivier Lesieur, Eloi Marijon, Xavier Jouven, Alain Cariou, Wulfran Bougouin, Sudden Death Expertise Centre investigators
Controlled donation after circulatory death (cDCD) in post-anoxic brain injury is a valuable source of organs that is still underused in some countries. We assessed the number of potential cDCD donors after out-of-hospital cardiac arrest (OHCA) in Paris and its suburbs and extrapolated the results to the French population. Using the large regional registry of the Great Paris area, we prospectively
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A retrospective, multi-agency ‘target trial emulation’ for the comparison of post-resuscitation epinephrine to norepinephrine Resuscitation (IF 6.5) Pub Date : 2024-04-04 Tanner Smida, Remle P. Crowe, P.S. Martin, James F. Scheidler, Bradley S. Price, James M. Bardes
Epinephrine and norepinephrine are the two most commonly used prehospital vasopressors in the United States. Prior studies have suggested that use of a post-ROSC epinephrine infusion may be associated with increased rearrest and mortality in comparison to use of norepinephrine. We used target trial emulation methodology to compare the rates of rearrest and mortality between the groups of OHCA patients
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Association between survival and number of shocks for pulseless ventricular arrhythmias during pediatric in-hospital cardiac arrest in a national registry Resuscitation (IF 6.5) Pub Date : 2024-04-04 Sarah E. Haskell, Derek Hoyme, M. Bridget Zimmerman, Ron Reeder, Saket Girotra, Tia T. Raymond, Ricardo A. Samson, Marc Berg, Robert A. Berg, Vinay Nadkarni, Dianne L. Atkins, the American Heart Association's Get With The Guidelines®-Resuscitation Investigators
Annually 15,200 children suffer an in-hospital cardiac arrest (IHCA) in the US. Ventricular fibrillation or pulseless ventricular tachycardia (VF/pVT) is the initial rhythm in 10–15% of these arrests. We sought to evaluate the association of number of shocks and early dose escalation with survival for initial VF/pVT in pediatric IHCA. Using 2000–2020 data from the American Heart Association’s (AHA)
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Accuracy of etiological classification of out-of-hospital cardiac arrest: A scoping review Resuscitation (IF 6.5) Pub Date : 2024-04-04 Sedigheh Shaeri, Julie Considine, Katie N. Dainty, Theresa Mariero Olasveengen, Laurie J. Morrison
The Utstein reporting template classifies the etiology of OHCA into “presumed cardiac” and “obvious non-cardiac” or “medical” and “non-medical” categories; however, the accuracy of these classifications is unclear. Ascertaining more accurately the etiology of OHCA is important to tailor advanced life support and identify etiologically consistent patient cohorts for reporting incidence and outcome and
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The effects of bystander interventions for foreign body airway obstruction on survival and neurological outcomes: Findings of the MOCHI registry Resuscitation (IF 6.5) Pub Date : 2024-04-04 Tatsuya Norii, Yutaka Igarashi, Yudai Yoshino, Shunichiro Nakao, MingAn Yang, Danielle Albright, David P. Sklar, Cameron Crandall
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Toxicological profile using mass spectrometry in sudden cardiac arrest survivors admitted to a tertiary centre Resuscitation (IF 6.5) Pub Date : 2024-04-04 Niels Kjær Stampe, Charlotte Glinge, Brian Schou Rasmussen, Priya Bhardwaj, Kristian Linnet, Reza Jabbari, Christian Paludan-Müller, Christian Hassager, Jesper Kjærgaard, Jacob Tfelt-Hansen, Bo Gregers Winkel
There has been no previous thorough toxicological examination of a cohort of patients with resuscitated sudden cardiac arrest. We aimed to determine the qualitative and quantitative drug composition in a resuscitated sudden cardiac arrest population, using forensic toxicology, with focus on prescribed, non-prescribed, and commonly abused drugs. Individuals aged 18–90 years with resuscitated sudden
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Spreading awareness about automated external defibrillators by using location-based mobile game called geocaching Resuscitation (IF 6.5) Pub Date : 2024-04-03 Nino Fijačko, Špela Metličar, Robert Greif
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The experiences of cardiac arrest survivors and their key supporters following cardiac arrest: A systematic review and meta-ethnography Resuscitation (IF 6.5) Pub Date : 2024-03-26 Charlotte Southern, Elizabeth Tutton, Katie N. Dainty, Kate Seers, Nathan A. Pearson, Keith Couper, David R. Ellard, Gavin D. Perkins, Kirstie L. Haywood
To review qualitative studies on the experience of sudden cardiac arrest survival from the perspective of both survivors and their key supporters, including family/close friends. A seven-step meta-ethnography and synthesis of qualitative evidence was undertaken, informed by the Meta-Ethnography Reporting Guidelines (eMERGe). Four major databases were searched (Medline, EMBASE, CINAHL, PsycINFO; January
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Strategic placement of automated external defibrillators at city bicycle-sharing stations: Exploring the potential Resuscitation (IF 6.5) Pub Date : 2024-03-24 Nino Fijačko, Inja Dokl, Špela Metličar, Robert Greif
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Resuscitation (un-)wanted: Does anyone care? A retrospective real data analysis Resuscitation (IF 6.5) Pub Date : 2024-03-24 Dennis Rupp, Nils Heuser, Martin Christian Sassen, Susanne Betz, Christian Volberg, Susanne Glass
In case of out-of-hospital cardiac arrest (OHCA) personnel of the emergency medical services (EMS) are regularly confronted with advanced directives (AD) and do-not-attempt-resuscitation (DNACPR) orders. The authors conducted a retrospective analysis of EMS operation protocols to examine the prevalence of DNACPR in case of OHCA and the influence of a presented DNACPR on CPR-duration, performed Advanced-Life-Support
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The impact of alternate defibrillation strategies on shock-refractory and recurrent ventricular fibrillation: A secondary analysis of the DOSE VF cluster randomized controlled trial Resuscitation (IF 6.5) Pub Date : 2024-03-24 Sheldon Cheskes, Ian R. Drennan, Linda Turner, Sandeep V. Pandit, Paul Dorian
The DOSE VF randomized controlled trial (RCT) employed a pragmatic definition of refractory ventricular fibrillation (VF after three successive shocks). However, it remains unclear whether the underlying rhythm during the first three shocks was shock-refractory or recurrent VF. To explore the relationship between alternate defibrillation strategies employed during the DOSE VF RCT and the type of VF
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Pediatric out-of-hospital cardiac arrest still needs more attention Resuscitation (IF 6.5) Pub Date : 2024-03-22 Ivie D. Esangbedo
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Reply to addressing the need for bilateral carotid evaluation in doppler monitoring studies for enhanced CPR outcomes Resuscitation (IF 6.5) Pub Date : 2024-03-22 Shuo Wang, Chunsheng Li
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Heroism, futility, and lactate physiology Resuscitation (IF 6.5) Pub Date : 2024-03-22 Zachary Shinar, Dinis Dos Reis Miranda
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Endotracheal epinephrine at standard versus high dose for resuscitation of asystolic newborn lambs Resuscitation (IF 6.5) Pub Date : 2024-03-22 Graeme R. Polglase, Yoveena Brian, Darcy Tantanis, Douglas A. Blank, Shiraz Badurdeen, Kelly J. Crossley, Martin Kluckow, Andrew W. Gill, Emily Camm, Robert Galinsky, Nils Thomas Songstad, Claus Klingenberg, Stuart B. Hooper, Calum T. Roberts
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How can we interpret the unexpected results in two pilot trials comparing thiamine to placebo after cardiac arrest? Resuscitation (IF 6.5) Pub Date : 2024-03-22 Markus B Skrifvars
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Open for business: The blood–brain barrier after cardiac arrest Resuscitation (IF 6.5) Pub Date : 2024-03-22 David J. Barton, Jonathan Elmer
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Not just surviving: Towards a quality standard which meets the care and rehabilitation needs of cardiac arrest survivors and their key supporters Resuscitation (IF 6.5) Pub Date : 2024-03-15 M. Bradfield, K.L. Haywood, M. Mion, A. Kayani, S. Leckey, on behalf of the RCUK Quality Standards Group for Care Rehabilitation of Cardiac Arrest Survivors Key Supporters
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Brain computed tomography after resuscitation from in-hospital cardiac arrest Resuscitation (IF 6.5) Pub Date : 2024-03-15 Cecelia Ratay, Jonathan Elmer, Clifton W. Callaway, Katharyn L. Flickinger, Patrick J. Coppler, on behalf of the University of Pittsburgh Post-Cardiac Arrest Service
Few data characterize the role of brain computed tomography (CT) after resuscitation from in-hospital cardiac arrest (IHCA). We hypothesized that identifying a neurological etiology of arrest or cerebral edema on brain CT are less common after IHCA than after resuscitation from out-of-hospital cardiac arrest (OHCA). We included all patients comatose after resuscitation from IHCA or OHCA in this retrospective
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Together we save: Uniting forces in manual and mechanical CPR Resuscitation (IF 6.5) Pub Date : 2024-03-15 Roos Edgar, Judith L. Bonnes
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Defining, divining, and defeating recurrent cardiac arrest Resuscitation (IF 6.5) Pub Date : 2024-03-12 Nicholas J. Johnson, Thomas D. Rea
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Sleep apnea, the risk of out-of-hospital cardiac arrest, and potential benefits of continuous positive airway pressure therapy: A nationwide study Resuscitation (IF 6.5) Pub Date : 2024-03-11 Pelpika Qayoumi, Ruben Coronel, Fredrik Folke, Anojhaan Arulmurugananthavadivel, Saaima Parveen, Harman Yonis, Amani Meaidi, Morten Lamberts, Morten Schou, Christian Torp-Pedersen, Gunnar Hilmar Gislason, Talip E. Eroglu
Patients with sleep apnea (SA) are at increased cardiovascular risk. However, little is known about the risk of out-of-hospital cardiac arrest (OHCA) in patients with SA. Therefore, we studied the relation between SA patients who did and did not receive continuous positive airway pressure (CPAP) therapy with OHCA in the general population. Using nationwide databases, we conducted a nested case-control
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The diagnostic accuracy of a shock advisory algorithm in automated external defibrillators in the presence of real-world artifacts Resuscitation (IF 6.5) Pub Date : 2024-03-11 Mengqi Gao, Chenguang Liu, Stacy Gehman, Kevin Burgett, Edward Kompare, Barbara Fink, Dawn B. Jorgenson
The current standards for shock advisory algorithms in AEDs require performance testing on artifact-free ECGs. However, AED analysis in the real world is more challenging due to potential artifacts from various sources (e.g., patient handling, and electromagnetic interference). This retrospective data analysis reports the real-world performance and behavior of a shock advisory algorithm used in three
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Corrigendum to “Tyrphostin reduces the organ injury in haemorrhagic shock: Role of inducible nitric oxide synthase” [Resuscitation 58(3) (2003) 349–361] Resuscitation (IF 6.5) Pub Date : 2024-03-11 Michelle McDonald, Maha Abdelrahman, Salvatore Cuzzocrea, Christoph Thiemermann
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Impact of a COVID-19 code blue protocol on resuscitation care and CPR quality during in-hospital cardiac arrest Resuscitation (IF 6.5) Pub Date : 2024-03-09 Christian Vaillancourt, Manya Charette, Soha Khorsand, Erica Shligold, Chelsea Lanos, Jennifer Dale-Tam, Alexandre Tran, Loree Boyle, Sylvie Aucoin, Jerry Maniate, Hilary Meggison, Michael Hartwick, Glenn Posner
We sought to evaluate the impact of a COVID-19 Code Blue policy on in-hospital cardiac arrest (IHCA) processes of care, cardiopulmonary resuscitation (CPR) quality metrics, and survival to hospital discharge. We completed a health record review of consecutive IHCA for which resuscitation was attempted. We report Utstein outcomes and CPR quality metrics 33 months before (July,2017-March,2020) and after
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Foreign body airway obstruction resulting in out-of-hospital cardiac arrest in Denmark – Incidence, survival and interventions Resuscitation (IF 6.5) Pub Date : 2024-03-09 Signe Amalie Wolthers, Mathias Geldermann Holgersen, Josefine Tangen Jensen, Mikkel Porsborg Andersen, Stig Nikolaj Fasmer Blomberg, Søren Mikkelsen, Helle Collatz Christensen, Theo Walther Jensen
Foreign body airway obstruction (FBAO) stands as an important contributor to accidental fatalities, yet prompt bystander interventions have been shown to improve survival. This study aimed to evaluate the incidence, interventions, and survival outcomes of patients with out-of-hospital cardiac arrest (OHCA) related to FBAO in comparison to patients with non-FBAO OHCA. In this population-based cohort
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TEMPORARY REMOVAL: Characterising trends in the initiation, timing, and completion of the Recommended Summary Plan for Emergency Care and Treatment (ReSPECT) process: Retrospective analysis of routine data from a large UK hospital trust Resuscitation (IF 6.5) Pub Date : 2024-03-07 Evrim Anik, Adam Hurlow, Desiree Azizoddin, Robert West, Felix Muehlensiepen, Gemma Clarke, Sarah Mitchell, Matthew Allsop
The publisher regrets that this article has been temporarily removed. A replacement will appear as soon as possible in which the reason for the removal of the article will be specified, or the article will be reinstated.
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Emotional distress, social support, and functional dependence predict readiness for hospital discharge in a prospective sample of cognitively intact cardiac arrest survivors Resuscitation (IF 6.5) Pub Date : 2024-03-06 Alexander M. Presciutti, Nomin Enkhtsetseg, Katharyn L. Flickinger, Patrick J. Coppler, Cecelia Ratay, Ankur A. Doshi, Sarah M. Perman, Ana-Maria Vranceanu, Jonathan Elmer
To inform screening, referral and treatment initiatives, we tested the hypothesis that emotional distress, social support, functional dependence, and cognitive impairment within 72 hours prior to discharge predict readiness for discharge in awake and alert cardiac arrest (CA) survivors. This was a secondary analysis of a prospective single-center cohort of CA survivors enrolled between 4/2021 and 9/2022
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Observer-reported cognitive decline in out-of-hospital cardiac arrest survivors and its association with long-term survivor and relative outcomes Resuscitation (IF 6.5) Pub Date : 2024-03-06 Vicky L. Joshi, Britt Borregaard, Tina Broby Mikkelsen, Lars H. Tang, Erik Blennow Nordström, Sofie Moesgaard Bruvik, Anders Wieghorst, Ann-Dorthe Zwisler, Mette Kirstine Wagner
Long-term cognitive decline after out-of-hospital cardiac arrest (OHCA) is still poorly understood. This study describes long-term observer-reported cognitive decline among Danish OHCA survivors, including differences in years since the event, and investigates characteristics and self-reported outcomes associated with observer-reported cognitive decline. Adults who survived an OHCA from 2016 to 2019
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Trends in presumed drug overdose out-of-hospital cardiac arrests in San Francisco, 2015–2023 Resuscitation (IF 6.5) Pub Date : 2024-03-06 Ralph C. Wang, Juan Carlos C. Montoy, Robert M. Rodriguez, James J. Menegazzi, Jeremy Lacocque, David G. Dillon
Estimates of the prevalence of drug-related out of hospital cardiac arrest (OHCA) vary, ranging from 1.8% to 10.0% of medical OHCA. However, studies conducted prior to the recent wave of fentanyl deaths likely underestimate the current prevalence of drug-related OHCA. We evaluated recent trends in drug-related OHCA, hypothesizing that the proportion of presumed drug-related OHCA treated by emergency
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Development and validation of a prehospital termination of resuscitation (TOR) rule for out - of hospital cardiac arrest (OHCA) cases using general purpose artificial intelligence (AI) Resuscitation (IF 6.5) Pub Date : 2024-03-05 Kentaro Kajino, Mohamud R. Daya, Atsunori Onoe, Fumiko Nakamura, Mari Nakajima, Kazuhito Sakuramoto, Marcus Eng Hock Ong, Yasuyuki Kuwagata
Prehospital identification of futile resuscitation efforts (defined as a predicted probability of survival lower than 1%) for out-of-hospital cardiac arrest (OHCA) may reduce unnecessary transport. Reliable prediction variables for OHCA 'termination of resuscitation' (TOR) rules are needed to guide treatment decisions. The Universal TOR rule uses only three variables (Absence of Prehospital ROSC, Event
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What is the best approach to assessing generative AI in medicine? Resuscitation (IF 6.5) Pub Date : 2024-03-04 Lingxuan Zhu, Weiming Mou, Jiarui Xie, Peng Luo, Rui Chen
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Association of coronary angiography with ST-elevation and no ST-elevation in patients with refractory ventricular fibrillation – A substudy of the DOuble SEquential External Defibrillation for Refractory Ventricular Fibrillation (DOSE-VF randomized control trial) Resuscitation (IF 6.5) Pub Date : 2024-03-04 Saswata Deb, Ian R. Drennan, Linda Turner, Sheldon Cheskes
Refractory ventricular fibrillation or pulseless ventricular tachycardia (rVF/pVT) during out-of-hospital cardiac arrest (OHCA) is associated with poor survival. Double sequential defibrillation (DSED) and vector change (VC) improved survival for rVF/pVT in the DOSE-VF RCT. However, the role of angiography and percutaneous coronary intervention (angiography/PCI) during the trial is unknown. To determine
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Airway management in resuscitation following drowning – Is drowning research “in hot water”? Resuscitation (IF 6.5) Pub Date : 2024-02-29 Paddy Morgan
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Thiamine as a metabolic resuscitator after out-of-hospital cardiac arrest Resuscitation (IF 6.5) Pub Date : 2024-02-28 Michael W. Donnino, Katherine M. Berg, Jacob Vine, Lakshman Balaji, Noa Berlin, Michael N. Cocchi, Ari Moskowitz, Maureen Chase, Franklin Li, Shivani Mehta, Jeremy Silverman, Stanley Heydrick, Xiaowen Liu, Anne V. Grossestreuer, BIDMC Center for Resuscitation Science at the time of their contributions
Thiamine is a key cofactor for aerobic metabolism, previously shown to improve mortality and neurological outcomes in a mouse model of cardiac arrest. We hypothesized that thiamine would decrease lactate and improve outcomes in post-arrest patients. Single center, randomized, blinded, placebo-controlled, Phase II trial of thiamine in adults within 4.5 hours of return of spontaneous circulation after
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Thiamine as a metabolic resuscitator after in-hospital cardiac arrest Resuscitation (IF 6.5) Pub Date : 2024-02-28 Katherine M. Berg, Anne V. Grossestreuer, Lakshman Balaji, Ari Moskowitz, Noa Berlin, Michael N. Cocchi, Andrea C. Morton, Franklin Li, Shivani Mehta, Natia Peradze, Jeremy Silverman, Xiaowen Liu, Michael W. Donnino
Elevated lactate is associated with mortality after cardiac arrest. Thiamine, a cofactor of pyruvate dehydrogenase, is necessary for aerobic metabolism. In a mouse model of cardiac arrest, thiamine improved pyruvate dehydrogenase activity, survival and neurologic outcome. To determine if thiamine would decrease lactate and increase oxygen consumption after in-hospital cardiac arrest. Randomized, double-blind
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A novel structured debriefing program for consensus determinations of in-hospital cardiac arrest predictability and preventability Resuscitation (IF 6.5) Pub Date : 2024-02-28 Patrick G. Lyons, Joe Reid, Sara Richardville, Dana P. Edelson
Hospital rapid response systems aim to stop preventable cardiac arrests, but defining preventability is a challenge. We developed a multidisciplinary consensus-based process to determine in-hospital cardiac arrest (IHCA) preventability based on objective measures. We developed an interdisciplinary ward IHCA debriefing program at an urban quaternary-care academic hospital. This group systematically
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Prodromal complaints and 30-day survival after emergency medical services-witnessed out-of-hospital cardiac arrest Resuscitation (IF 6.5) Pub Date : 2024-02-28 Mia Bang Larsen, Emil Blom-Hanssen, Filip Gnesin, Kristian Hay Kragholm, Thomas Lass Klitgaard, Helle Collatz Christensen, Freddy Lippert, Fredrik Folke, Christian Torp-Pedersen, Kristian Bundgaard Ringgren
Out-of-hospital cardiac arrest (OHCA) is a frequent and lethal condition with a yearly incidence of approximately 5000 in Denmark. Thirty-day survival is associated with the patient’s prodromal complaints prior to cardiac arrest. This paper examines the odds of 30-day survival dependent on the reported prodromal complaints among OHCAs witnessed by the emergency medical services (EMS). EMS-witnessed
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Newborn resuscitation timelines: Accurately capturing treatment in the delivery room Resuscitation (IF 6.5) Pub Date : 2024-02-27 Hanne Pike, Vilde Kolstad, Joar Eilevstjønn, Peter G. Davis, Hege Langli Ersdal, Siren Rettedal
To evaluate the use of newborn resuscitation timelines to assess the incidence, sequence, timing, duration of and response to resuscitative interventions. A population–based observational study conducted June 2019–November 2021 at Stavanger University Hospital, Norway. Parents consented to participation antenatally. Newborns ≥28 weeks’ gestation receiving positive pressure ventilation (PPV) at birth
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Lactate and lactate clearance as predictors of one-year survival in extracorporeal cardiopulmonary resuscitation – An international, multicentre cohort study Resuscitation (IF 6.5) Pub Date : 2024-02-23 Tharusan Thevathasan, Emilie Gregers, Sivagowry Rasalingam Mørk, Sêhnou Degbeon, Louise Linde, Jo Bønding Andreasen, Morten Smerup, Jacob Eifer Møller, Christian Hassager, Helle Laugesen, Henryk Dreger, Anna Brand, Felix Balzer, Ulf Landmesser, Christian Juhl Terkelsen, Jens Flensted Lassen, Carsten Skurk, Helle Søholm
[Display omitted]
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Blood-brain barrier permeability for the first 24 hours in hypoxic-ischemic brain injury following cardiac arrest Resuscitation (IF 6.5) Pub Date : 2024-02-23 Yeonho You, Jung Soo Park, Jin Hong Min, Wonjoon Jeong, Hong Joon Ahn, Yong Nam In, So Young Jeon, Jae Kwang Lee, Changshin Kang
This study aimed to explore the changes in blood–brain barrier (BBB) permeability and intracranial pressure (ICP) for the first 24 h after the return of spontaneous circulation (ROSC) and their association with injury severity of cardiac arrest. This prospective study analysed the BBB permeability assessed using the albumin quotient (Qa) and ICP every 2 h for the first 24 h after ROSC. The injury severity
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Health-related quality of life and cognitive function after out-of-hospital cardiac arrest; a comparison of prehospital return-of-spontaneous circulation and refractory arrest managed with extracorporeal cardiopulmonary resuscitation Resuscitation (IF 6.5) Pub Date : 2024-02-23 Emilie Gregers, Louise Linde, Joakim Bo Kunkel, Sebastian Wiberg, Peter Hasse Møller-Sørensen, Morten Smerup, Britt Borregaard, Henrik Schmidt, Jens Flensted Lassen, Jacob Eifer Møller, Christian Hassager, Helle Søholm, Jesper Kjærgaard
Extracorporeal cardiopulmonary resuscitation (ECPR) for selected refractory out-of-hospital cardiac arrest (OHCA) is increasingly used. Detailed knowledge of health-related quality of life (HRQoL) and long-term cognitive function is limited. HRQoL and cognitive function were assessed in ECPR-survivors and OHCA-survivors with prehospital return of spontaneous circulation after standard advanced cardiac
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Multi-phase implementation of automated external defibrillator use by nurses during in-hospital cardiac arrest and its impact on survival Resuscitation (IF 6.5) Pub Date : 2024-02-19 Christian Vaillancourt, Manya Charette, Chelsea Lanos, Justin Godbout, Hannah Buhariwalla, Jennifer Dale-Tam, Marie-Joe Nemnom, Jamie Brehaut, George Wells, Ian Stiell
We sought to evaluate the impact of a medical directive allowing nurses to use defibrillators in automated external defibrillator-mode (AED) on in-hospital cardiac arrest (IHCA) outcomes. We completed a health record review of consecutive IHCA for which resuscitation was attempted using a pragmatic multi-phase before-after cohort design. We report Utstein outcomes before (Jan.2012–Aug.2013;Control)
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One year after implementation of «super lay-rescuers» equipped with AED to improve survival of OHCA Resuscitation (IF 6.5) Pub Date : 2024-02-16 François Morin, Delphine Douillet, Emma Sokpoh, Lionel Lamhaut, Dominique Savary