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Trends in Number and Appropriateness of Prescription Medication Utilization among Community-Dwelling Older Adults in the US: 2011-2020 J. Gerontol. A Biol. Sci. Med. Sci. (IF 5.1) Pub Date : 2024-04-22 Shaoxi Pan, Shanshan Li, Shaoxiang Jiang, Jung-Im Shin, Gordon G Liu, Hongyan Wu, Beini Lyu
Background Contemporary data on the quantity and quality of medication use among older adults are lacking. This study examined recent trends in number and appropriateness of prescription medication use among older adults in the US. Method Data from the National Health and Nutrition Examination Survey (NHANES) between 2011 and March 2020 were used and 6336 adult participants aged 65 and older were included
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Dietary vitamin C intake and changes in frequency, severity, and location of pain in older adults J. Gerontol. A Biol. Sci. Med. Sci. (IF 5.1) Pub Date : 2024-04-22 Mario Delgado-Velandia, Rosario Ortolá, Esther García-Esquinas, Adrián Carballo-Casla, Mercedes Sotos-Prieto, Fernando Rodríguez-Artalejo
Background Oral vitamin C supplementation has been associated with lower risk of chronic postsurgical pain. However, the effect of dietary vitamin C on pain in a non-surgical setting is unknown. We aimed to investigate the association between dietary vitamin C intake and changes over time in chronic pain and its characteristics in community-dwelling adults aged 60+ years. Methods We pooled data from
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Inhaled pollutants of the Gero-Exposome and later life health J. Gerontol. A Biol. Sci. Med. Sci. (IF 5.1) Pub Date : 2024-04-22 Caleb E Finch, Max A Thorwald
Inhaled air pollutants (AirP) comprise extraordinarily diverse particles, volatiles, and gases from traffic, wildfire, cigarette smoke, dust, and various other sources. These pollutants contain numerous toxic components which collectively differ in relative levels of components, but broadly share chemical classes. Exposure and health outcomes from AirP are complex, depending on pollutant source, duration
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Dementia Prevalence, Incidence and Mortality Trends Among US Adults Ages 72 and Older, 2011-2021 J. Gerontol. A Biol. Sci. Med. Sci. (IF 5.1) Pub Date : 2024-04-20 Vicki A Freedman, Jennifer C Cornman
Background U.S.-focused studies have reported decreasing dementia prevalence in recent decades, but have not yet focused on the implications of the COVID-19 pandemic for trends. Methods We use the 2011-2021 National Health and Aging Trends Study (N=48,065) to examine dementia prevalence, incidence and mortality trends among adults ages 72 and older, and the contribution to prevalence trends of changes
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Kinship And Care: Racial Disparities In Potential Dementia Caregiving In The U.S. From 2000 To 2060 J. Gerontol. A Biol. Sci. Med. Sci. (IF 5.1) Pub Date : 2024-04-20 Kai Feng, Xi Song, Hal Caswell
Background Although the family plays a pivotal role in older adults’ care, there is limited research on how evolving demographic trends affect older adults’ support networks and how the trends vary by race. To fill this gap, we examine the influence of shifting family demographics on future care needs for older adults with dementia, emphasizing the unequal health and potential caregiving burdens by
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Racial/Ethnic Differences in Self-Reported Upper Limb Limitations among U.S. Older Adults J. Gerontol. A Biol. Sci. Med. Sci. (IF 5.1) Pub Date : 2024-04-20 Rachel N Logue Cook, Matthew A Davis, Rebecca E Hasson, Dominique Kinnett-Hopkins, Susan H Brown
Background The development of disability related to activities of daily living (ADL) is of great concern in the aging population, particularly for Hispanic and Non-Hispanic (NH) Black older adults, where disability prevalence is greater compared to NH Whites. ADL-disability is typically measured across many functional tasks without differentiating upper- versus lower-limb limitations, hindering our
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The association of the 24-hour activity cycle profiles with cognition in older adults with mild cognitive impairment: A cross-sectional study J. Gerontol. A Biol. Sci. Med. Sci. (IF 5.1) Pub Date : 2024-04-20 Guilherme Moraes Balbim, Ryan S Falck, Nárlon Cássio Boa Sorte Silva, Arthur F Kramer, Michelle Voss, Teresa Liu-Ambrose
Background The relationship of cognition and the 24-hour activity cycles (24-HAC), encompassing physical activity, sedentary behaviour, and sleep, in older adults with mild cognitive impairment (MCI) remains uncertain. Distinct combinations of 24-HAC behaviours can characterize unique activity profiles and influence cognition. We aimed to characterize 24-HAC activity profiles in older adults with MCI
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Muscle mitochondrial bioenergetic capacities are associated with multimorbidity burden in older adults: the Study of Muscle, Mobility and Aging (SOMMA) J. Gerontol. A Biol. Sci. Med. Sci. (IF 5.1) Pub Date : 2024-04-11 Theresa Mau, Terri L Blackwell, Peggy M Cawthon, Anthony J A Molina, Paul M Coen, Giovanna Distefano, Philip A Kramer, Sofhia V Ramos, Daniel E Forman, Bret H Goodpaster, Frederico G S Toledo, Kate A Duchowny, Lauren M Sparks, Anne B Newman, Stephen B Kritchevsky, Steven R Cummings
Background The geroscience hypothesis posits that aging biological processes contribute to many age-related deficits, including the accumulation of multiple chronic diseases. Though only one facet of mitochondrial function, declines in muscle mitochondrial bioenergetic capacities may contribute to this increased susceptibility to multimorbidity. Methods The Study of Muscle, Mobility and Aging (SOMMA)
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Peripheral Blood Cells from Older Adults Exhibit Sex-Associated Differences in Mitochondrial Function J. Gerontol. A Biol. Sci. Med. Sci. (IF 5.1) Pub Date : 2024-04-10 Gargi Mahapatra, Zhengrong Gao, James R Bateman, Samuel Neal Lockhart, Jaclyn Bergstrom, Jemima Elizabeth Piloso, Suzanne Craft, Anthony J A Molina
Blood based mitochondrial bioenergetic profiling is a feasible, economical, and minimally invasive approach that can be used to examine mitochondrial function and energy metabolism in human subjects. In this study, we use two complementary respirometric techniques to evaluate mitochondrial bioenergetics in both intact and permeabilized peripheral blood mononuclear cells (PBMCs) and platelets to examine
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Profiles of Lifestyle Health Behaviors and Postmortem Dementia-Related Neuropathology J. Gerontol. A Biol. Sci. Med. Sci. (IF 5.1) Pub Date : 2024-04-10 Brittney S Lange-Maia, Maude Wagner, Christina A Rogers, Rupal I Mehta, David A Bennett, Christy Tangney, Michael E Schoeny, Shannon Halloway, Zoe Arvanitakis
High engagement in lifestyle health behaviors appears to be protective against cognitive decline in aging. We investigated the association between patterns of modifiable lifestyle health behaviors and common brain neuropathologies of dementia as a possible mechanism. We examined 555 decedents from the Rush Memory and Aging Project, free of dementia at their initial concurrent report of lifestyle health
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Abstracts BMAS Summer School 2023—2nd Bone Marrow Adiposity Society Summer School Meeting 2023 J. Gerontol. A Biol. Sci. Med. Sci. (IF 5.1) Pub Date : 2024-04-06 Biagio Palmisano, Michaela Tencerova
Fat is the main component of an adult bone marrow and constitutes the so-called bone marrow adipose tissue (BMAT). Marrow adipocytes, which are the fat cells in the bone marrow, become more abundant with age, and may influence the whole-body metabolism. In osteoporotic patients, the amount of BMAT has an inverse correlation with the amount of bone mass. In people with anorexia nervosa that lose weight
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The Drug Burden Index is associated with Measures of Cognitive Function Among Older Adults in the Health, Aging, and Body Composition Study J. Gerontol. A Biol. Sci. Med. Sci. (IF 5.1) Pub Date : 2024-04-03 Janie C DiNatale, Ian M McDonough, Amy C Ellis, Joy W Douglas, Kristine Yaffe, Kristi M Crowe-White
BACKGROUND Anticholinergic and sedative medications impact cognition among older adults. The Drug Burden Index (DBI) is a validated measure of exposure to these medications, with higher DBI scores indicating higher drug burden. This ancillary analysis investigated the association between DBI and cognition assessed by the Modified Mini-Mental State Examination (3MS) and the Digit Symbol Substitution
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An Increase in Vascular Stiffness is Positively Associated with Mitochondrial Bioenergetics Impairment of Peripheral Blood Mononuclear Cells in the Elderly Population J. Gerontol. A Biol. Sci. Med. Sci. (IF 5.1) Pub Date : 2024-04-03 Tanawat Attachaipanich, Sirawit Sriwichaiin, Nattayaporn Apaijai, Sasiwan Kerdphoo, Nisakron Thongmung, Prin Vathesatogkit, Piyamitr Sritara, Nipon Chattipakorn, Chagriya Kitiyakara, Siriporn C Chattipakorn
The cardio-ankle vascular index (CAVI) is a non-invasive parameter reflecting vascular stiffness. CAVI correlates with the burden of atherosclerosis and future cardiovascular events. Mitochondria of peripheral blood mononuclear cells (PBMCs) have been identified as a non-invasive source for assessing systemic mitochondrial bioenergetics. This study aimed to investigate the relationship between CAVI
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Validation of a Rule-Based ICD-10-CM Algorithm to Detect Fall Injuries in Medicare Data J. Gerontol. A Biol. Sci. Med. Sci. (IF 5.1) Pub Date : 2024-04-03 David A Ganz, Denise Esserman, Nancy K Latham, Michael Kane, Lillian C Min, Thomas M Gill, David B Reuben, Peter Peduzzi, Erich J Greene
Background Diagnosis-code-based algorithms to identify fall injuries in Medicare data are useful for ascertaining outcomes in interventional and observational studies. However, these algorithms have not been validated against a fully external reference standard, in ICD-10-CM, or in Medicare Advantage (MA) data. Methods We linked self-reported fall injuries leading to medical attention (FIMA) from the
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Claims-Based Frailty Index and Its Relationship with Commonly Used Clinical Frailty Measures J. Gerontol. A Biol. Sci. Med. Sci. (IF 5.1) Pub Date : 2024-04-01 Stephanie Denise M Sison, Sandra M Shi, Gahee Oh, Sohyun Jeong, Ellen P McCarthy, Dae Hyun Kim
Background The relationship of claims-based frailty index (CFI), a validated measure to identify frail individuals using Medicare data, and frailty measures used in clinical practice has not yet been fully explored. Methods We identified community-dwelling participants of the 2015 National Health and Aging Trends Study (NHATS) whose CFI scores could be calculated using linked Medicare claims. We calculated
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Inhibition of DAPK3 suppresses radiation-induced cellular senescence by activation of a PGC1α-dependent metabolism pathway in brain endothelial cells J. Gerontol. A Biol. Sci. Med. Sci. (IF 5.1) Pub Date : 2024-04-01 Ji-Eun Park, Jeong Woo Park, Myong-Kyu Sim, So Ra Kim, Kwang Seok Kim
In the brain, environmental changes, such as neuroinflammation, can induce senescence, characterized by the decreased proliferation of neurons and dendrites and synaptic and vascular damage, resulting in cognitive decline. Senescence promotes neuroinflammatory disorders by senescence-associated secretory phenotypes and ROS. In human brain microvascular endothelial cells (HBMVECs), we demonstrate that
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Associations of Social Support with Physical and Mental Health Symptom Burden After COVID-19 Hospitalization Among Older Adults J. Gerontol. A Biol. Sci. Med. Sci. (IF 5.1) Pub Date : 2024-03-30 Seohyuk Lee, Gail J McAvay, Mary Geda, Sumon Chattopadhyay, Denise Acampora, Katy Araujo, Peter Charpentier, Thomas M Gill, Alexandra M Hajduk, Andrew B Cohen, Lauren E Ferrante
Background Despite significant support system disruptions during the COVID-19 pandemic, little is known about the relationship between social support and symptom burden among older adults following COVID-19 hospitalization. Methods From a prospective cohort of 341 community-living persons aged ≥60 years hospitalized with COVID-19 between June 2020-June 2021 who underwent follow-up at 1, 3, and 6 months
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The Association between Postural Sway and Preclinical Alzheimer Disease among Community-Dwelling Older Adults J. Gerontol. A Biol. Sci. Med. Sci. (IF 5.1) Pub Date : 2024-03-30 Rebecca M Bollinger, Szu-Wei Chen, Melissa J Krauss, Audrey A Keleman, Abigail Kehrer-Dunlap, Megan Kaesler, Beau M Ances, Susan L Stark
Background It is unknown whether older adults with preclinical Alzheimer disease (AD) experience changes in postural sway compared to those without preclinical AD. The purpose of this study was to understand the effect of dual tasking on standing balance, or postural sway, for people with and without preclinical AD. Methods A cross-sectional analysis of baseline data from a longitudinal cohort study
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Longitudinal evolution and plasma biomarkers for excessive daytime sleepiness in Parkinson's disease J. Gerontol. A Biol. Sci. Med. Sci. (IF 5.1) Pub Date : 2024-03-25 Junyu Lin, Chunyu Li, Ruwei Ou, Yanbing Hou, Lingyu Zhang, Qianqian Wei, Kuncheng Liu, Qirui Jiang, Tianmi Yang, Yi Xiao, Dejiang Pang, Yujiao Yu, Wei Song, Bi Zhao, Xueping Chen, Jing Yang, Ying Wu, Huifang Shang
Background Excessive daytime sleepiness (EDS) is one of the most frequent non-motor symptoms in Parkinson's disease (PD); however, the pathogenesis of EDS is unclear, and there is a lack of information on plasma biomarkers for EDS in PD. We aimed to investigate the plasma biomarkers of EDS in a large PD cohort. Methods A total of 159 PD patients were included in the prospective cohort study and followed
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Associations between onset age of orthostatic hypotension and incident myocardial infarction, stroke, and dementia: a prospective cohort study J. Gerontol. A Biol. Sci. Med. Sci. (IF 5.1) Pub Date : 2024-03-25 Jie Liang, Wenya Zhang, Yang Pan, Darui Gao, Yongqian Wang, Wuxiang Xie, Fanfan Zheng
Background The associations of age at orthostatic hypotension onset with incident myocardial infarction (MI), stroke, and dementia remain unknown. This study aimed to examine whether younger onset age of orthostatic hypotension was associated with higher risks of incident MI, stroke, and dementia. Methods Data were obtained from the UK Biobank. Information on the diagnosis of orthostatic hypotension
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Links of Previous Incarceration with Geriatric Syndromes and Chronic Health Conditions Among Older Adults in the United States J. Gerontol. A Biol. Sci. Med. Sci. (IF 5.1) Pub Date : 2024-03-22 Alexander Testa, Dylan B Jackson, Meghan Novisky, Christopher Kaufmann, Carmen Gutierrez, Jack Tsai, Adam P Spira, Roland J Thorpe
Background This study investigated the association between previous incarceration and various geriatric and chronic health conditions among adults 50 and older in the United States. Methods Data came from the National Longitudinal Study of Adolescent to Adult Health – Parent Study (AHPS) collected in 2015-2017, including 2,007 individuals who participated in the parent study (Parent Sample) and 976
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Exercise to Mitigate Cerebrovascular Aging: A Geroscience Perspective J. Gerontol. A Biol. Sci. Med. Sci. (IF 5.1) Pub Date : 2024-03-22 Amani M Norling, Lewis A Lipsitz
Aging is characterized by a progressive loss of cellular functions that increase the risk of developing chronic diseases, vascular dysfunction, and neurodegenerative conditions. The field of geroscience has identified cellular and molecular hallmarks of aging that may serve as targets for future interventions to reduce the risk of age-related disease and disability. These hallmarks include genomic
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Association of plasma n-3 polyunsaturated fatty acid levels and the prevalence of frailty in older adults: a cross-sectional analysis of UK Biobank J. Gerontol. A Biol. Sci. Med. Sci. (IF 5.1) Pub Date : 2024-03-21 Junghyun Kim, Jason Westra, Nathan Tintle, William S Harris, Yongsoon Park
Background Circulating levels of n-3 polyunsaturated fatty acids (PUFAs) have been associated with frailty among Koreans (a population with a high intake of fish), but whether this association exists in Western populations with low fish intake is unknown. The present study examined the hypothesis that the prevalence of frailty was inversely associated with plasma levels of n-3 PUFAs, with the intake
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Advancing Aging Research through a Health Disparities Perspective J. Gerontol. A Biol. Sci. Med. Sci. (IF 5.1) Pub Date : 2024-03-19 Juliana Teruel Camargo, Jessica T Smith, Erik J Rodriquez, Eliseo J Pérez-Stable
The proportion of older adults in the U.S. is growing, and the older adult population is also becoming increasingly diverse. However, there are limited data on the aging process and older adults in underserved populations. Equitable participation in research studies on aging, the research workforce, and the healthcare workforce is critical to improve health outcomes for the entire U.S. population.
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Navigating the Landscape of Translational Geroscience in Canada: A Comprehensive Evaluation of Current Progress and Future Directions J. Gerontol. A Biol. Sci. Med. Sci. (IF 5.1) Pub Date : 2024-03-15 Guy Hajj-Boutros, Andréa Faust, John Muscedere, Perry Kim, Naji Abumrad, Stéphanie Chevalier, Mylene Aubertin-Leheudre, Howard Bergman, Dawn Bowdish, Jessica Burford, Stacy Carrington-Lawrence, Hélène Côté, David E Dawe, Philipe de Souto Barreto, Colin Farrelly, Robert Fowler, Gilles Gouspillou, Lea Harrington, Sofie Lautrup, Susan Howlett, Mahdi Imani, James Kirkland, George Kuchel, Frédérick A Mallette
The inaugural Canadian Conferences on Translational Geroscience were held as two complementary sessions in October and November 2023. The conferences explored the profound interplay between the biology of aging, social determinants of health, the potential societal impact of geroscience and the maintenance of health in aging individuals. Although topics such as cellular senescence, molecular and genetic
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Increased Risk of New-Onset Parkinson’s Disease Following a Diagnosis of Retinal Vascular Occlusion: A 14-year Cohort Study J. Gerontol. A Biol. Sci. Med. Sci. (IF 5.1) Pub Date : 2024-03-12 Seung Hoon Kim, Minah Park, Sung Hoon Jeong
Background Although the role of the vascular component in the pathophysiology of Parkinson’s disease is widely accepted and retinal vascular abnormalities are commonly observed in Parkinson’s disease patients, evidence connecting retinal vascular disorders with the risk of developing Parkinson’s disease is limited. We aimed to investigate the association between retinal vascular occlusion and the risk
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Loneliness, living alone and risk of cardiovascular disease among older adults in China J. Gerontol. A Biol. Sci. Med. Sci. (IF 5.1) Pub Date : 2024-03-12 Siyue Tan, Dong Liu, Yuyi Zhang, Shengnan Li, Ke Zhang, Zaixiang Tang, Hui Zuo
Background Older adults are prone to live alone and feel lonely. The main objective of this study was to assess the associations of loneliness and living alone with cardiovascular disease (CVD) among community-dwelling older individuals in China. Methods We conducted a longitudinal analysis on 3661 participants aged over 65 years from the latest 2014 and 2018 waves of the Chinese Longitudinal Healthy
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Pain characteristics and progression to sarcopenia in Chinese middle-aged and older adults: a 4-year longitudinal study J. Gerontol. A Biol. Sci. Med. Sci. (IF 5.1) Pub Date : 2024-03-12 Jintao Chen, Liying Yan, Jingjing Chu, Xinyi Wang, Zherong Xu
Background It is imperative for public health to identify the factors that contribute to the progression of sarcopenia among middle-aged and older adults. Our study aimed to investigate the association between pain characteristics and the progression to sarcopenia and its subcomponents among middle-aged and older adults in China. Methods We included 5568 participants from the China Health and Retirement
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Lack of Immune-resilience negatively affects Physical-resilience. Results from the InCHIANTI follow-up study J. Gerontol. A Biol. Sci. Med. Sci. (IF 5.1) Pub Date : 2024-03-07 Raffaello Pellegrino, Roberto Paganelli, Angelo Di Iorio, Stefania Bandinelli, Chiara Mussi, Eleonora Sparvieri, Stefano Volpato, Toshiko Tanaka, Luigi Ferrucci
There is consistent evidence that immune response declines with aging, with wide inter-individual variability and a still unclear relationship with the development of frailty. To address this question we assessed the role of immune resilience (capacity to restore immune functions), operationalized as the neutrophil-to-lymphocytes ratio (NL-ratio) and monocytes-to-lymphocytes ratio (ML-ratio), in the
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Genome-Wide Polygenic Score for Muscle Strength Predicts Risk for Common Diseases and Lifespan: A Prospective Cohort Study J. Gerontol. A Biol. Sci. Med. Sci. (IF 5.1) Pub Date : 2024-03-07 Päivi Herranen, Kaisa Koivunen, Teemu Palviainen, Urho M Kujala, Samuli Ripatti, Jaakko Kaprio, Elina Sillanpää
Background We used a polygenic score for hand grip strength (PGS HGS) to investigate whether genetic predisposition for higher muscle strength predicts age-related noncommunicable diseases, survival from acute adverse health events, and mortality. Methods This study consisted of 342 443 Finnish biobank participants from FinnGen Data Freeze 10 (53% women) aged 40 to 108 with combined genotype and health
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Effects of Multicomponent Home-Based Intervention on Muscle Composition, Fitness and Bone Density after Hip Fracture J. Gerontol. A Biol. Sci. Med. Sci. (IF 5.1) Pub Date : 2024-03-07 Alice S Ryan, Brock A Beamer, Ann L Gruber-Baldini, Rebecca L Craik, Justine Golden, Jack Guralnik, Marc C Hochberg, Kathleen K Mangione, Denise Orwig, Alan M Rathbun, Jay Magaziner
Background Mechanistic factors on the pathway to improving independent ambulatory ability among hip fracture patients by a multicomponent home-based physical therapy intervention that emphasized aerobic, strength, balance, and functional training are unknown. The aim of this study was to determine the effects of two different home-based physical therapy programs on muscle area and attenuation (reflects
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Association of combined healthy lifestyle factors with incident dementia in participants with and without multimorbidity: a large population-based prospective cohort study J. Gerontol. A Biol. Sci. Med. Sci. (IF 5.1) Pub Date : 2024-03-07 Ying-ying Niu, Jian-feng Zhong, Hui-yan Wen, Hao-yu Yan, Zhi-quan Diao, Jia-xin Li, Xue-rui Bai, Jia-min Qiu, Zhi-tong Xu, Lian-hong Chen, Cheng-ping Li, Jing Li, Xiao-feng Liang, Dan Liu
BACKGROUND The effect of a healthy lifestyle on dementia associated with multimorbidity-related is not well-understood. Our objective is to examine whether the adoption of a healthy lifestyle could potentially reduce the elevated risk of dementia in individuals with and without multimorbidity. METHODS We utilized data from the UK Biobank cohort. A comprehensive healthy lifestyle score, ranging from
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Association between serum NT-proBNP and gray matter atrophy patterns in an older Japanese population: the Hisayama Study J. Gerontol. A Biol. Sci. Med. Sci. (IF 5.1) Pub Date : 2024-03-06 Naoki Hirabayashi, Jun Hata, Yoshihiko Furuta, Taro Nakazawa, Tomoyuki Ohara, Mao Shibata, Fumio Yamashita, Takanari Kitazono, Nobuyuki Sudo, Toshiharu Ninomiya
Several population-based studies have reported that higher serum N-terminal pro-brain natriuretic peptide (NT-proBNP) levels are associated with brain morphological changes. However, no population-based studies have examined the relationship between serum NT-proBNP and various regional brain volumes in detail. We here analyzed the brain MRI data of 1,201 community-dwelling Japanese aged ≥65 years.
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Circular RNA circVmn2r1 acts as a miR-223-3p sponge to promote kidney aging by regulating NLRP3 expression in mice J. Gerontol. A Biol. Sci. Med. Sci. (IF 5.1) Pub Date : 2024-03-06 Fanfan Gao, Limin Wei, Jie Li, Lu Zeng, Meng Wang, Ping Lan, Shanshan Liang, Xinmei Huang, Lei Chen, Hongli Jiang
Kidney aging accelerates the progression of various acute and chronic kidney diseases and can also induce pathological changes in other organs throughout the body. Circular RNAs (circRNAs), have been demonstrated to play a vital role in aging and age-related diseases. However, biological functions and the underlying molecular mechanism of circRNAs in kidney aging remain largely unclear. Uncovering
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Predictors of urinary and faecal incontinence in pre-frail and frail older adults: a cross-sectional study of the FRAGSALUD project J. Gerontol. A Biol. Sci. Med. Sci. (IF 5.1) Pub Date : 2024-03-04 Juan Corral-Pérez, Laura Ávila-Cabeza-de-Vaca, Inmaculada Valero-Cantero, Andrea González-Mariscal, Jesús G Ponce-González, María Ángeles Vázquez-Sánchez, Cristina Casals
Background Frailty is associated with urinary and faecal incontinence, which are common geriatric syndromes. This study aims to identify health factors associated with incontinence in pre-frail or frail older adults living in the community. Methods This multicentre cross-sectional study included 225 older adults (75.0±6.4 years) with pre-frailty or frailty based on the five-component Fried phenotype
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Chewing disability is associated with cognitive impairment among older adults: a population-based cohort study J. Gerontol. A Biol. Sci. Med. Sci. (IF 5.1) Pub Date : 2024-03-02 Gustavo G Nascimento, Huihua Li, Rahul Malhotra, Fábio R M Leite, Karen G Peres, Angelique Chan, Marco A Peres
Background Chewing disability is associated with impaired quality of life, potentially leading to depression and cognitive impairment. While the chewing-ability-cognition relationship has been explored, examining whether depression mediates this relationship remains unclear. We investigated the association between chewing disability and cognitive impairment development and a potential mediation via
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The Impact of Type 2 Diabetes on Peripheral and Cerebral Haemodynamic Responses to Active Stand J. Gerontol. A Biol. Sci. Med. Sci. (IF 5.1) Pub Date : 2024-03-01 Belinda Hernández, Adam H Dyer, Ciaran Finucane, Bernardo Nipoti, Roman Romero-Ortuno, Richard Reilly, Rose Anne Kenny
Background Whilst Type 2 Diabetes Mellitus (T2DM) is an established risk factor for cognitive impairment, the underlying mechanisms remain poorly explored. One potential mechanism may be through effects of T2DM on cerebral perfusion. The current study hypothesised that T2DM is associated with altered peripheral and central haemodynamic responses to orthostasis, which may in turn be associated with
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Young Plasma Rejuvenates Blood Dna Methylation Profile, Extends Mean Lifespan And Improves Physical Appearance In Old Rats J. Gerontol. A Biol. Sci. Med. Sci. (IF 5.1) Pub Date : 2024-02-29 Priscila Chiavellini, Marianne Lehmann, Maria D Gallardo, Martina Canatelli Mallat, Diana C Pasquini, Joseph A Zoller, Juozas Gordevicius, Mauricio Girard, Ezequiel Lacunza, Claudia B Herenu, Steve Horvath, Rodolfo G Goya
There is converging evidence that young blood conveys cells, vesicles and molecules able to revitalize function and restore organ integrity in old individuals. We assessed the effects of young plasma on the lifespan, epigenetic age and healthspan of old female rats. Beginning at 25.6 months of age, a group of 9 rats (group T) was i.p. injected with plasma from young rats until their natural death.
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Life history trade-offs in Drosophila: flies select a diet to maximize reproduction at the expense of lifespan J. Gerontol. A Biol. Sci. Med. Sci. (IF 5.1) Pub Date : 2024-02-29 Olha Strilbytska, Uliana Semaniuk, Dmytro Gospodaryov, Stephen J Simpson, Oleh Lushchak
Macronutrient intake impacts physiology, behavior, physiology and gene expression in a wide range of organisms. We used the response surface methodology to compare how life history traits, lifespan and reproduction differ as a function of protein and carbohydrate intakes under choice and no-choice feeding regimens in the fruit fly, Drosophila melanogaster. We found that when offered a choice of nutritionally
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Age is Associated with Dampened Circadian Patterns of Rest and Activity: The Study of Muscle, Mobility and Aging (SOMMA) J. Gerontol. A Biol. Sci. Med. Sci. (IF 5.1) Pub Date : 2024-02-28 Melissa L Erickson, Terri L Blackwell, Theresa Mau, Peggy M Cawthon, Nancy W Glynn, Yujia (Susanna) Qiao, Steven R Cummings, Paul M Coen, Nancy E Lane, Stephen B Kritchevsky, Anne B Newman, Samaneh Farsijani, Karyn A Esser
Background The effects of aging on circadian patterns of behavior are insufficiently described. To address this, we characterized age-specific features of rest-activity rhythms (RAR) in community dwelling older adults both overall, and in relation, to sociodemographic characteristics. Methods We examined cross-sectional associations between RAR and age, sex, race, education, multimorbidity burden,
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Genome-wide search links senescence-associated secretory proteins with susceptibility for coronary artery disease in mouse and human J. Gerontol. A Biol. Sci. Med. Sci. (IF 5.1) Pub Date : 2024-02-28 Yuan-Zheng Zhu, Jian-Kun Liu, Xue-Er Li, Zhen-Ping Yu, Lu-Qin Yang, Qin Wan, Ya Zhao, Muhammad Saeed, An-Dong Wu, Xiao-Li Tian
Advanced age is an independent risk factor for coronary artery disease (CAD), the leading global cause of mortality. Senescent vascular cells in the atherosclerotic plaques exhibit senescence-associated secretory phenotype (SASP). How SASP contributes to atherosclerosis and CAD, however, remains unclear. Here we integrated RNA-array datasets of senescent human coronary arterial endothelial cells (HCAECs)
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LncRNA Gm15232 Promotes Lipogenesis in Aging Mice Through the miR-192-3p/GCR Pathway J. Gerontol. A Biol. Sci. Med. Sci. (IF 5.1) Pub Date : 2024-02-27 Yaqi Hu, Yifan Zhang, Shuwen Wang, Rui Wang, Qi Yuan, Wei Wu, Yibei Gui, Jiale Zhao, Xueqing Li, Yumin He, Chengfu Yuan
Recent scientific studies have highlighted the importance of long chain non-coding RNAs (lncRNAs) in a variety of metabolic diseases, but the specific functions and mechanisms of lncRNAs in aberrant lipid synthesis associated with aging are unknown. In this work, we inspected the effects of lncRNAs on the lipid metabolism in aging mice, as substantial evidence suggests that aging disturbs lipid metabolism
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Postural control characteristics in Alzheimer’s disease, dementia with Lewy bodies, and vascular dementia J. Gerontol. A Biol. Sci. Med. Sci. (IF 5.1) Pub Date : 2024-02-27 Kosuke Fujita, Taiki Sugimoto, Hisashi Noma, Yujiro Kuroda, Nanae Matsumoto, Kazuaki Uchida, Yoshinobu Kishino, Takashi Sakurai
Background Dementia often results in postural control impairment, which could signify central nervous system dysfunction. However, no studies have compared postural control characteristics among various types of dementia. This study aimed to compare static postural control in patients with Alzheimer's disease (AD), dementia with Lewy bodies (DLB), and vascular dementia (VaD). Methods Cross-sectional
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DHCR24 insufficiency promotes vascular endothelial cell senescence and endothelial dysfunction via inhibition of Caveolin-1/ERK signaling J. Gerontol. A Biol. Sci. Med. Sci. (IF 5.1) Pub Date : 2024-02-25 Han Li, Zhen Yang, Wukaiyang Liang, Hao Nie, Yuqi Guan, Ni Yang, Tianyi Ji, Yu Liu, Yi Huang, Le Zhang, Jinhua Yan, Cuntai Zhang
Endothelial cells (ECs) senescence is critical for vascular dysfunction, which leads to age-related disease. DHCR24, a 3β-hydroxysterol δ 24 reductase with multiple functions other than enzymatic activity, has been involved in age-related disease. However, little is known about the relationship between DHCR24 and vascular ECs senescence. We revealed that DHCR24 expression is chronologically decreased
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Longitudinal quantiles of frailty trajectories considering death: new insights into sex and cohort differences in the reference curves for frailty progression of older European J. Gerontol. A Biol. Sci. Med. Sci. (IF 5.1) Pub Date : 2024-02-23 Alejandra Marroig, Fernando Massa, Annie Robitaille, Scott M Hofer, Erwin Stolz, Graciela Muniz-Terrera
Background Most previous studies of frailty trajectories in older adults focus on the average trajectory and ignore death. Longitudinal quantile analysis of frailty trajectories permits the definition of reference curves, and the application of mortal cohort inference provides more realistic estimates than models that ignore death. Methods Using data from individuals aged 65 or older (n=25446) from
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Non-coding RNA contribution to aging and lifespan J. Gerontol. A Biol. Sci. Med. Sci. (IF 5.1) Pub Date : 2024-02-23 Alejandro Piñeiro Ugalde, David Roiz del Valle, Lucas Moledo Nodar, Xurde Menéndez Caravia, José María Pérez Freije, Carlos López Otín
Aging is a multifactorial process characterized by an age-related decline in organismal fitness. This deterioration is the major risk factor for chronic diseases such as cardiovascular pathologies, neurodegeneration or cancer, and it represents one of the main challenges of modern society. Therefore, understanding why and how we age would be a fundamental pillar to design strategies to promote a healthy
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The complexity of center of pressure positions during quiet stance and its relationship to cognition, aging and falls J. Gerontol. A Biol. Sci. Med. Sci. (IF 5.1) Pub Date : 2024-02-23 Antoine Langeard, Emma Milot, Gaëlle Quarck, Thomas Stoffregen
BACKGROUND In a secondary analysis of data taken from a publicly available database, we examined cognitive performance, postural sway, and relations between them for four groups: younger and older individuals with versus without a recent history of falls. Our objective was to compare linear versus nonlinear measures of postural activity as post-hoc predictors of cognitive performance and falling. METHODS
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Association of testosterone and sex hormone-binding globulin with all-cause and cardiovascular disease mortality in older Chinese men J. Gerontol. A Biol. Sci. Med. Sci. (IF 5.1) Pub Date : 2024-02-23 Mei Jiao Li, Chao Qiang Jiang, Ya Li Jin, Tong Zhu, Feng Zhu, Wei Sen Zhang, Lin Xu
Background The associations of high and low testosterone with all-cause and cardiovascular disease (CVD) mortality risk in men are conflicting. Our objective was to examine associations of total testosterone, free testosterone, bioavailable testosterone, and sex hormone-binding globulin (SHBG) with all-cause and CVD mortality in older Chinese men. Methods Total testosterone and SHBG were assayed, and
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Predictors of frailty transitions in Mexican older adults J. Gerontol. A Biol. Sci. Med. Sci. (IF 5.1) Pub Date : 2024-02-22 Ana Rivera-Almaraz, Aarón Salinas-Rodríguez, Eduardo Gutiérrez-Peña, Betty Soledad Manrique-Espinoza
Background Frailty is a dynamic state in older adults. Current evidence, mostly in high-income countries, found that improving frailty is more likely in mild states (prefrailty). We aimed to determine the probability of frailty transitions and their predictors. Methods Participants were adults aged 50 years or over from the Study on Global Ageing and Adult Health in Mexico during 4 waves (2009, 2014
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White Matter Plasticity Underpins Cognitive Gains after Multidomain Adaptive Computerized Cognitive Training J. Gerontol. A Biol. Sci. Med. Sci. (IF 5.1) Pub Date : 2024-02-22 Xiangwei Dai, Sihan Liu, Yumeng Li, Shijie Long, Xin Li, Chuansheng Chen, Caishui Yang, Junying Zhang, Zhuo Rachel Han, He Li, Jun Wang, Zhanjun Zhang
Background This study aims to evaluate the effectiveness of computerized cognitive training (CCT) on white matter (WM) neuroplasticity and neuropsychological performance. Methods A total of 128 community older adults (64.36 ± 6.14 years) were recruited and randomly assigned to the intervention or the control group. Participants in the intervention group received a home-based, multidomain, and adaptive
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Abdominal body composition reference ranges and association with chronic conditions in an age- and sex-stratified representative sample of a geographically defined American population J. Gerontol. A Biol. Sci. Med. Sci. (IF 5.1) Pub Date : 2024-02-19 Alexander D Weston, Brandon R Grossardt, Hillary W Garner, Timothy L Kline, Alanna M Chamberlain, Alina M Allen, Bradley J Erickson, Walter A Rocca, Andrew D Rule, Jennifer L St. Sauver
Background Body composition can be accurately quantified from abdominal CT exams and is a predictor for the development of aging-related conditions and for mortality. However, reference ranges for CT-derived body composition measures of obesity, sarcopenia, and bone loss have yet to be defined in the general population. Methods We identified a population-representative sample of 4,900 persons aged
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The Impact of Air Pollution on Physical Functioning Decline and the Benefits of Greenness: Evidence from a Nationwide Cohort Study J. Gerontol. A Biol. Sci. Med. Sci. (IF 5.1) Pub Date : 2024-02-19 Ke Zhang, Jie He, Zhongyang Chen, Mengnan Pan, Jiahui Tong, Dejian Kou, Feifei Liu, Hao Xiang
Background Physical functional limitations (PFLs) increase the vulnerability of adults, but their pathogenesis remains unclear. Methods We conducted a nationwide longitudinal study on 62,749 records from 18,878 adults (aged ≥45) from 28 provinces in China. Risk of PFLs was assessed using a validated 9-item questionnaire. Exposure levels of air pollutants (PM10, PM2.5, and PM1) and greenness (Normalized
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Metabolome-wide Mendelian Randomization Assessing the Causal Relationship between Blood Metabolites and Sarcopenia-related Traits J. Gerontol. A Biol. Sci. Med. Sci. (IF 5.1) Pub Date : 2024-02-17 Simin Chen, Yiran Dong, Nuerbiyamu Aiheti, Jie Wang, Shikang Yan, Kaidiriyan Kuribanjiang, Huilong Li, Xing Peng, Abudunaibi Wupuer, Yihan Li, Lei Yang, Jianping Zhao
Sarcopenia is among the most common musculoskeletal illnesses, yet its underlying biochemical mechanisms remain incompletely understood. In this study, we used Mendelian randomization (MR) to investigate the causal relationship between the genetically determined blood metabolites and sarcopenia, with the overall objective of identifying likely molecular pathways for sarcopenia. We used two-sample MR
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Cacao Procyanidins-Induced Lifespan Extension in Caenorhabditis elegans in a Nervous System and CaMKII Dependent Manner J. Gerontol. A Biol. Sci. Med. Sci. (IF 5.1) Pub Date : 2024-02-17 Keiya Ohmine, Yuki Morinaga, Sarina Kobayashi, Aika Matsubara, Kaito Sadanaga, Shuhei Tohtani, Hideaki Saeki, Hiroto Horiuchi, Yuta Fujikawa, Koichiro Sumi, Midori Natsume, Hideshi Inoue
Procyanidins are gaining attention due to their potential health benefits. We found that cacao liquor procyanidin (CLPr) from Theobroma cacao seeds increased the lifespan of Caenorhabditis elegans, a representative model organism for aging studies. The genetic dependence of the lifespan-extending effect of CLPr was consistent with that of blueberry procyanidin, which is dependent on unc-43, osr-1,
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Associations between D3Cr muscle mass and MR thigh muscle volume with strength, power, physical performance, fitness, and limitations in older adults in the SOMMA study J. Gerontol. A Biol. Sci. Med. Sci. (IF 5.1) Pub Date : 2024-02-17 Peggy M Cawthon, Terri L Blackwell, Stephen B Kritchevsky, Anne B Newman, Russell T Hepple, Paul M Coen, Bret H Goodpaster, Kate Duchowny, Megan Hetherington-Rauth, Theresa Mau, Mahalakshmi Shankaran, Marc Hellerstein, William J Evans, Steven R Cummings
Background How magnetic resonance (MR) derived thigh muscle volume and d3-creatine dilution derived muscle mass (D3Cr muscle mass) differentially relate to strength, fitness, and other functional in older adults - and whether associations vary by sex - is not known. Methods Men (N=345) and women (N=482) aged ≥70 years from the Study of Muscle, Mobility and Aging completed leg extension strength (1-repetition
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Skeletal muscle ageing: lessons from teleosts J. Gerontol. A Biol. Sci. Med. Sci. (IF 5.1) Pub Date : 2024-02-16 Tuyen K Quach, Megan F Taylor, Peter D Currie, Nir Eynon, Avnika A Ruparelia
Ageing is the greatest risk factor for a multitude of age-related diseases including sarcopenia -the loss of skeletal muscle mass and strength - which occurs at remarkable rates each year. There is an unmet need not only to understand the mechanisms that drive sarcopenia, but also to identify novel therapeutic strategies. Given the ease and affordability of husbandry, along with advances in genomics
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Effect of gut microbiota-mediated tryptophan metabolism on inflammaging in frailty and sarcopenia J. Gerontol. A Biol. Sci. Med. Sci. (IF 5.1) Pub Date : 2024-02-16 Yu Shuang Xu, Tao Mao, You Jun Wang, Xing Si Qi, Wen Jun Zhao, Hao Chen, Cui Ping Zhang, Xiao Yu Li
Frailty syndrome refers to the nonspecific state of increased body vulnerability and decreased antistress and recovery abilities after stress during aging. Sarcopenia is the major component of frailty and is characterized by the gradual loss of muscle mass, strength, and function with age. Inflammaging is the gradual increase in inflammatory status during aging, and it disrupts immune tolerance, causes
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“Cognitive” Criteria in Older Adults with Slow Gait Speed: Implications for Motoric Cognitive Risk Syndrome J. Gerontol. A Biol. Sci. Med. Sci. (IF 5.1) Pub Date : 2024-02-13 Caroline O Nester, Qi Gao, Cuiling Wang, Mindy J Katz, Richard B Lipton, Joe Verghese, Laura A Rabin
Background Motoric Cognitive Risk Syndrome (MCR) is a predementia condition that combines slow gait speed and subjective cognitive concerns (SCC). The SCC criterion is presently unstandardized, possibly limiting risk detection. We sought to: 1. Characterize SCC practices through MCR literature review; 2. Investigate the ability of SCC in slow gait individuals in predicting the likelihood of cognitive
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Develop and validate a prognostic index with laboratory tests to predict mortality in middle-aged and older adults using machine learning models: a prospective cohort study J. Gerontol. A Biol. Sci. Med. Sci. (IF 5.1) Pub Date : 2024-02-13 Chi-Hsien Huang, Yao-Hwei Fang, Shu Zhang, I-Chien Wu, Shu-Chun Chuang, Hsing-Yi Chang, Yi-Fen Tsai, Wei-Ting Tseng, Ray-Chin Wu, Yen-Tze Liu, Li-Ming Lien, Chung-Chou Juan, Chikako Tange, Rei Otsuka, Hidenori Arai, Chih-Cheng Hsu, Chao Agnes Hsiung
Background Prognostic indices can enhance personalized predictions of health burdens. However, a simple, practical and reproducible tool is lacking for clinical use. This study aimed to develop a machine learning-based prognostic index for predicting all-cause mortality in community-dwelling elderly individuals. Methods We utilized the Healthy Aging Longitudinal Study in Taiwan (HALST) cohort, encompassing
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Associations of Neurological Biomarkers in Serum with Gait Measures: The Cardiovascular Health Study J. Gerontol. A Biol. Sci. Med. Sci. (IF 5.1) Pub Date : 2024-02-09 Abhijay Nadkarni, Kenneth J Mukamal, Xiaonan Zhu, David Siscovick, Jennifer S Brach, Mini Jacob, Sudha Seshadri, Temidayo Abe, Caterina Rosano, Luc Djousse, Andrea L Rosso
Background Gait impairment leads to increased mobility decline and may have neurological contributions. This study explores how neurological biomarkers are related to gait in older adults. Methods We studied participants in the Cardiovascular Health Study, a population-based cohort of older Americans, who underwent a serum biomarker assessment from samples collected in 1996-97 for neurofilament light-chain