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Global, regional and national burdens of depression in adolescents and young adults aged 10–24 years, from 1990 to 2019: findings from the 2019 Global Burden of Disease study Br. J. Psychiatry (IF 10.5) Pub Date : 2024-04-25 Cheng-hao Yang, Jia-jie Lv, Xiang-meng Kong, Feng Chu, Zhi-bin Li, Wei Lu, Xin-yu Li
Background Depression is a significant mental health concern affecting the overall well-being of adolescents and young adults. Recently, the prevalence of depression has increased among young people. Nonetheless, there is little research delving into the longitudinal epidemiology of adolescent depression over time.Aims To investigate the longitudinal epidemiology of depression among adolescents and
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Resolution of tonic concentrations of highly similar neurotransmitters using voltammetry and deep learning Mol. Psychiatry (IF 11.0) Pub Date : 2024-04-25 Abhinav Goyal, Jason Yuen, Stephen Sinicrope, Bailey Winter, Lindsey Randall, Aaron E. Rusheen, Charles D. Blaha, Kevin E. Bennet, Kendall H. Lee, Hojin Shin, Yoonbae Oh
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Gut microbiome predicts cognitive function and depressive symptoms in late life Mol. Psychiatry (IF 11.0) Pub Date : 2024-04-25 A. Kolobaric, C. Andreescu, E. Jašarević, C. H. Hong, H. W. Roh, J. Y. Cheong, Y. K. Kim, T. S. Shin, C. S. Kang, C. O. Kwon, S. Y. Yoon, S. W. Hong, H. J. Aizenstein, H. T. Karim, S. J. Son
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Neuroactive steroid hormone trajectories across the menstrual cycle in premenstrual dysphoric disorder (PMDD): the PHASE study Mol. Psychiatry (IF 11.0) Pub Date : 2024-04-25 Ajna Hamidovic, Sunni Mumford, Enrique Schisterman, John Davis, Fatimata Soumare
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The need for youth psychiatry fellowship: a physician-scientist trainee perspective Mol. Psychiatry (IF 11.0) Pub Date : 2024-04-24 Cemal Demirlek
In a recent perspective article of Uhlhaas et al. [1] in Molecular Psychiatry, the authors discuss the importance of the age range between 12 and 25 for understanding and addressing mental disorders. They emphasize the importance of risk and protective factors, as well as brain development, in youth psychopathology, especially during sensitive periods. The authors propose the need for a youth mental
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Thy1-ApoE4/C/EBPβ double transgenic mice act as a sporadic model with Alzheimer’s disease Mol. Psychiatry (IF 11.0) Pub Date : 2024-04-24 Zhengjiang Qian, ZhiHao Wang, Bowei Li, Xin Meng, Zhonghua Kuang, Yanjiao Li, Yongfeng Yang, Keqiang Ye
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The impact of psychosocial adversity on brain and behaviour: an overview of existing knowledge and directions for future research Mol. Psychiatry (IF 11.0) Pub Date : 2024-04-24 Nilakshi Vaidya, Andre F. Marquand, Frauke Nees, Sebastian Siehl, Gunter Schumann
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How does the macroenvironment influence brain and behaviour—a review of current status and future perspectives Mol. Psychiatry (IF 11.0) Pub Date : 2024-04-24 Elli Polemiti, Sören Hese, Kerstin Schepanski, Jiacan Yuan, Gunter Schumann
The environment influences brain and mental health, both detrimentally and beneficially. Existing research has emphasised the individual psychosocial ‘microenvironment’. Less attention has been paid to ‘macroenvironmental’ challenges, including climate change, pollution, urbanicity, and socioeconomic disparity. Notably, the implications of climate and pollution on brain and mental health have only
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Endogenous mutant Huntingtin alters the corticogenesis via lowering Golgi recruiting ARF1 in cortical organoid Mol. Psychiatry (IF 11.0) Pub Date : 2024-04-23 Yang Liu, Xinyu Chen, Yunlong Ma, Chenyun Song, Jixin Ma, Cheng Chen, Jianzhong Su, Lixiang Ma, Hexige Saiyin
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Post-Dobbs Challenges in Research and Patient Protections JAMA Psychiatry (IF 25.8) Pub Date : 2024-04-24 Aimee N. C. Campbell, Shelly F. Greenfield
This Viewpoint describes the challenges for clinical research and participant protections following the US Supreme Court ruling in Dobbs v Jackson Women’s Health Organization.
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Cognitive Behavior Therapy vs Mindfulness in Treatment of Prolonged Grief Disorder JAMA Psychiatry (IF 25.8) Pub Date : 2024-04-24 Richard A. Bryant, Suzanna Azevedo, Srishti Yadav, Catherine Cahill, Lucy Kenny, Fiona Maccallum, Jenny Tran, Jasmine Choi-Christou, Natasha Rawson, Julia Tockar, Benjamin Garber, Dharani Keyan, Katie S. Dawson
ImportanceAlthough grief-focused cognitive behavior therapies are the most empirically supported treatment for prolonged grief disorder, many people find this treatment difficult. A viable alternative for treatment is mindfulness-based cognitive therapy.ObjectiveTo examine the relative efficacies of grief-focused cognitive behavior therapy and mindfulness-based cognitive therapy to reduce prolonged
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Adolescents Who Do Not Endorse Risk via the Patient Health Questionnaire Before Self-Harm or Suicide JAMA Psychiatry (IF 25.8) Pub Date : 2024-04-24 Jean P. Flores, Geoffrey Kahn, Robert B. Penfold, Elizabeth A. Stuart, Brian K. Ahmedani, Arne Beck, Jennifer M. Boggs, Karen J. Coleman, Yihe G. Daida, Frances L. Lynch, Julie E. Richards, Rebecca C. Rossom, Gregory E. Simon, Holly C. Wilcox
ImportanceGiven that the Patient Health Questionnaire (PHQ) item 9 is commonly used to screen for risk of self-harm and suicide, it is important that clinicians recognize circumstances when at-risk adolescents may go undetected.ObjectiveTo understand characteristics of adolescents with a history of depression who do not endorse the PHQ item 9 before a near-term intentional self-harm event or suicide
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Recreational Marijuana Laws and Teen Marijuana Use, 1993-2021 JAMA Psychiatry (IF 25.8) Pub Date : 2024-04-24 D. Mark Anderson, Hao T. Fe, Yang Liang, Joseph J. Sabia
This cross-sectional study uses data from the Youth Risk Behavior surveys to assess the association of state-level recreational marijuana laws and youth marijuana use.
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Developing psychological treatments for psychosis Br. J. Psychiatry (IF 10.5) Pub Date : 2024-04-23 Daniel Freeman
Evidence shows that talking with patients about psychotic experiences can be beneficial. The key question is therefore: which psychological methods can help patients most? This editorial presents ten principles for the design and development of effective psychological treatments. These principles are perceptible characteristics of successful interventions.
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The role of psychosis and clozapine load in excessive checking in treatment-resistant schizophrenia: longitudinal observational study Br. J. Psychiatry (IF 10.5) Pub Date : 2024-04-23 Emilio Fernandez-Egea, Shanquan Chen, Estela Sangüesa, Patricia Gassó, Marjan Biria, James Plaistow, Isaac Jarratt-Barnham, Nuria Segarra, Sergi Mas, Maria-Pilar Ribate, Cristina B. García, Naomi A. Fineberg, Yulia Worbe, Rudolf N. Cardinal, Trevor W. Robbins
Background A significant proportion of people with clozapine-treated schizophrenia develop ‘checking’ compulsions, a phenomenon yet to be understood.Aims To use habit formation models developed in cognitive neuroscience to investigate the dynamic interplay between psychosis, clozapine dose and obsessive–compulsive symptoms (OCS).Method Using the anonymised electronic records of a cohort of clozapine-treated
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Combined expansion and STED microscopy reveals altered fingerprints of postsynaptic nanostructure across brain regions in ASD-related SHANK3-deficiency Mol. Psychiatry (IF 11.0) Pub Date : 2024-04-22 Jan Philipp Delling, Helen Friedericke Bauer, Susanne Gerlach-Arbeiter, Michael Schön, Christian Jacob, Jan Wagner, Maria Teresa Pedro, Bernd Knöll, Tobias M. Boeckers
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Characterization of transcriptional profiles associated with stress-induced neuronal activation in Arc-GFP mice Mol. Psychiatry (IF 11.0) Pub Date : 2024-04-22 Tamer Butto, Monika Chanu Chongtham, Kanak Mungikar, Dewi Hartwich, Matthias Linke, Nicolas Ruffini, Konstantin Radyushkin, Susann Schweiger, Jennifer Winter, Susanne Gerber
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Ethnic density and first episode psychosis in the British Pakistani population: findings from the East Lancashire Early Intervention Service Br. J. Psychiatry (IF 10.5) Pub Date : 2024-04-18 Robert Qi, Masood Qureshi, Nadeem Gire, Imran B. Chaudhry, Victoria Vass, Jason C. McIntyre, Kaylee Barlow, Richard P. Bentall, Ross G. White, Nusrat Husain
Background Elevated risk of psychosis for ethnic minority groups has generally been shown to be mitigated by high ethnic density. However, past survey studies examining UK Pakistani populations have shown an absence of protective ethnic density effects, which is not observed in other South Asian groups.Aims To assess the ethnic density effect at a local neighbourhood level, in the UK Pakistani population
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Neuroimaging of posttraumatic stress disorder in adults and youth: progress over the last decade on three leading questions of the field Mol. Psychiatry (IF 11.0) Pub Date : 2024-04-17 Cecilia A. Hinojosa, Grace C. George, Ziv Ben-Zion
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Traumatic Brain Injury and Risk of Schizophrenia and Other Non-mood Psychotic Disorders: Findings From a Large Inpatient Database in the United States Schizophr. Bull. (IF 6.6) Pub Date : 2024-04-18 Chintan Trivedi, Preetam Reddy, Abid Rizvi, Karrar Husain, Kimberly Brown, Zeeshan Mansuri, Mahamudun Nabi, Shailesh Jain
Background Traumatic brain injury (TBI) is linked with an increased risk of schizophrenia and other non-mood psychotic disorders (psychotic disorders), but the prevalence and contributing factors of these psychiatric conditions post-TBI remain unclear. This study explores this link to identify key risk factors in TBI patients. Methods We used the 2017 National Inpatient Sample dataset. Patients with
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Dissonance in the face of Alzheimer's disease breakthroughs: clinician and lay stakeholder acceptance, concerns and willingness to pay for emerging disease-modifying therapies Br. J. Psychiatry (IF 10.5) Pub Date : 2024-04-17 Irina Kinchin, Sharon Walsh, Rachel Dinh, Margaret Kapuwa, Sean P. Kennelly, Ann-Marie Miller, Ann Nolan, Sean O'Dowd, Laura O'Philbin, Suzanne Timmons, Iracema Leroi
Background Introducing new disease-modifying therapies (DMTs) for Alzheimer's disease demands a fundamental shift in diagnosis and care for most health systems around the world. Understanding the views of health professionals, potential patients, care partners and taxpayers is crucial for service planning and expectation management about these new therapies.Aims To investigate the public's and professionals’
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Prevalence of Mental Health Disorders Among Individuals Experiencing Homelessness JAMA Psychiatry (IF 25.8) Pub Date : 2024-04-17 Rebecca Barry, Jennifer Anderson, Lan Tran, Anees Bahji, Gina Dimitropoulos, S. Monty Ghosh, Julia Kirkham, Geoffrey Messier, Scott B. Patten, Katherine Rittenbach, Dallas Seitz
ImportanceSeveral factors may place people with mental health disorders, including substance use disorders, at increased risk of experiencing homelessness and experiencing homelessness may also increase the risk of developing mental health disorders. Meta-analyses examining the prevalence of mental health disorders among people experiencing homelessness globally are lacking.ObjectiveTo determine the
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Digital Mental Health’s Unstable Dichotomy—Wellness and Health JAMA Psychiatry (IF 25.8) Pub Date : 2024-04-17 John Torous, Joseph Firth, Simon B. Goldberg
This Viewpoint discusses the unacknowledged risks and harms and unrealized clinical benefits of digital mental wellness and health technologies and offers suggestions for ways to catalyze the next phase of these technologies by focusing on safety, evidence, and engagement.
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Examining Sex Differences in Autism Heritability JAMA Psychiatry (IF 25.8) Pub Date : 2024-04-17 Sven Sandin, Benjamin H. K. Yip, Weiyao Yin, Lauren A. Weiss, Joseph D. Dougherty, Stuart Fass, John N. Constantino, Zhu Hailin, Tychele N. Turner, Natasha Marrus, David H. Gutmann, Stephan J. Sanders, Benjamin Christoffersson
ImportanceAutism spectrum disorder (ASD) is a neurodevelopmental disorder more prevalent in males than in females. The cause of ASD is largely genetic, but the association of genetics with the skewed sex ratio is not yet understood. To our knowledge, no large population-based study has provided estimates of heritability by sex.ObjectiveTo estimate the sex-specific heritability of ASD.Design, Setting
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Erythropoietin restrains the inhibitory potential of interneurons in the mouse hippocampus Mol. Psychiatry (IF 11.0) Pub Date : 2024-04-15 Yasmina Curto, Héctor Carceller, Patrycja Klimczak, Marta Perez-Rando, Qing Wang, Katharina Grewe, Riki Kawaguchi, Silvio Rizzoli, Daniel Geschwind, Klaus-Armin Nave, Vicent Teruel-Marti, Manvendra Singh, Hannelore Ehrenreich, Juan Nácher
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From clinical psychiatry to implementation research and back again Lancet Psychiatry (IF 64.3) Pub Date : 2024-04-15 The Lancet Psychiatry
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Non-fatal suicide behaviours: recommendations for addressing mental health Lancet Psychiatry (IF 64.3) Pub Date : 2024-04-15 Clara González-Sanguino, Berta Ausín Benito, Manuel Muñoz López
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Climate change and mental health: a call for a global research agenda Lancet Psychiatry (IF 64.3) Pub Date : 2024-04-15 Amruta Nori-Sarma, Sandro Galea
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Heat and hospital admission via the emergency department for people with intellectual disability, autism, and mental disorders in South Korea: a nationwide, time-stratified, case-crossover study Lancet Psychiatry (IF 64.3) Pub Date : 2024-04-15 Jinah Park MPH, Ayoung Kim BSc, Prof Michelle L Bell PhD, Prof Ho Kim PhD, Prof Whanhee Lee PhD
Given the anticipated increase in ambient temperature due to climate change, the hazardous effects of heat on health have been extensively studied; however, its impact on people with intellectual disability, autism, and mental illness is largely unknown. We aimed to estimate the association between heat and hospitalisation through the emergency department (ED) among people with these mental disorders
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Non-fatal suicide behaviours across phases in the COVID-19 pandemic: a population-based study in a Catalan cohort Lancet Psychiatry (IF 64.3) Pub Date : 2024-04-15 Víctor Serrano-Gimeno MD, Alba Diestre MD, Marina Agustin-Alcain MD, Maria J Portella PhD, Javier de Diego-Adeliño MD PhD, Thaïs Tiana PsyD, Nora Cheddi MD, Alejandro Distefano MD, Guillermo Dominguez MD, Marina Arias MMath, Victor Cardoner MMath, Dolors Puigdemont MD PhD, Prof Victor Perez MD PhD, Prof Narcís Cardoner MD PhD
The COVID-19 pandemic has been extensively discussed in the context of its effect on mental health. Although global suicide rates have remained stable during the pandemic, the specific effect on non-fatal suicide behaviours during and after the pandemic remains underexplored. This study aims to investigate patterns of non-fatal suicide behaviours before, during, and after the pandemic. In this cohort
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Shared Genetic Determinants of Schizophrenia and Autism Spectrum Disorder Implicate Opposite Risk Patterns: A Genome-Wide Analysis of Common Variants Schizophr. Bull. (IF 6.6) Pub Date : 2024-04-15 Yu Chen, Wenqiang Li, Luxian Lv, Weihua Yue
Background and Hypothesis The synaptic pruning hypothesis posits that schizophrenia (SCZ) and autism spectrum disorder (ASD) may represent opposite ends of neurodevelopmental disorders: individuals with ASD exhibit an overabundance of synapses and connections while SCZ was characterized by excessive pruning of synapses and a reduction. Given the strong genetic predisposition of both disorders, we propose
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Assessing Trial-by-Trial Electrophysiological and Behavioral Markers of Attentional Control and Sensory Precision in Psychotic and Mood Disorders Schizophr. Bull. (IF 6.6) Pub Date : 2024-04-15 Megan A Boudewyn, Molly A Erickson, Kurt Winsler, Deanna M Barch, Cameron S Carter, Michael J Frank, James M Gold, Angus W MacDonald, J Daniel Ragland, Steven M Silverstein, Andrew P Yonelinas, Steven J Luck
Background and Hypothesis The current study investigated the extent to which changes in attentional control contribute to performance on a visual perceptual discrimination task, on a trial-by-trial basis in a transdiagnostic clinical sample. Study Design Participants with schizophrenia (SZ; N = 58), bipolar disorder (N = 42), major depression disorder (N = 51), and psychiatrically healthy controls
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Nuclear GAPDH in cortical microglia mediates cellular stress-induced cognitive inflexibility Mol. Psychiatry (IF 11.0) Pub Date : 2024-04-13 Adriana Ramos, Koko Ishizuka, Arisa Hayashida, Ho Namkung, Lindsay N. Hayes, Rupali Srivastava, Manling Zhang, Taro Kariya, Noah Elkins, Trexy Palen, Elisa Carloni, Tsuyoshi Tsujimura, Coleman Calva, Satoshi Ikemoto, Rana Rais, Barbara S. Slusher, Minae Niwa, Atsushi Saito, Toshiaki Saitoh, Eiki Takimoto, Akira Sawa
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Dentate gyrus is needed for memory retrieval Mol. Psychiatry (IF 11.0) Pub Date : 2024-04-12 Alejandro Carretero-Guillén, Mario Treviño, María Ángeles Gómez-Climent, Godwin K. Dogbevia, Ilaria Bertocchi, Rolf Sprengel, Matthew E. Larkum, Andreas Vlachos, Agnès Gruart, José M. Delgado-García, Mazahir T. Hasan
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Robust and replicable functional brain signatures of 22q11.2 deletion syndrome and associated psychosis: a deep neural network-based multi-cohort study Mol. Psychiatry (IF 11.0) Pub Date : 2024-04-12 Kaustubh Supekar, Carlo de los Angeles, Srikanth Ryali, Leila Kushan, Charlie Schleifer, Gabriela Repetto, Nicolas A. Crossley, Tony Simon, Carrie E. Bearden, Vinod Menon
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Dosage effects of psychodynamic and schema therapy in people with comorbid depression and personality disorder: four-arm pragmatic randomised controlled trial Br. J. Psychiatry (IF 10.5) Pub Date : 2024-04-11 Marit Kool, Henricus Van, Arnoud Arntz, Anna Bartak, Jaap Peen, Linda Dil, Katinka de Boer, Jack Dekker
Background Higher intensity of psychotherapy might improve treatment outcome in depression, especially in those with comorbid personality disorder.Aims To compare the effects of 25 individual sessions (weekly) of two forms of psychotherapy – short-term psychoanalytic supportive psychotherapy (SPSP) and schema therapy – with the same treatments given for 50 sessions (twice weekly) in people with depression
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Longitudinal inference of multiscale markers in psychosis: from hippocampal centrality to functional outcome Mol. Psychiatry (IF 11.0) Pub Date : 2024-04-11 Jana F. Totzek, M. Mallar Chakravarty, Ridha Joober, Ashok Malla, Jai L. Shah, Delphine Raucher-Chéné, Alexandra L. Young, Dennis Hernaus, Martin Lepage, Katie M. Lavigne
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Impaired topology and connectivity of grey matter structural networks in major depressive disorder: evidence from a multi-site neuroimaging data-set Br. J. Psychiatry (IF 10.5) Pub Date : 2024-04-11 Jing-Yi Long, Kun Qin, Nanfang Pan, Wen-Liang Fan, Yi Li
Background Major depressive disorder (MDD) has been increasingly understood as a disruption of brain connectome. Investigating grey matter structural networks with a large sample size can provide valuable insights into the structural basis of network-level neuropathological underpinnings of MDD.Aims Using a multisite MRI data-set including nearly 2000 individuals, this study aimed to identify robust
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Exploring the genetic etiology across the continuum of the general psychopathology factor: a Swedish population-based family and twin study Mol. Psychiatry (IF 11.0) Pub Date : 2024-04-10 Yangjun Liu, Paul Lichtenstein, Roman Kotov, Henrik Larsson, Brian M. D’Onofrio, Erik Pettersson
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Essentials of Informed Consent to Psychedelic Medicine JAMA Psychiatry (IF 25.8) Pub Date : 2024-04-10 Mason Marks, Rebecca W. Brendel, Carmel Shachar, I. Glenn Cohen
ImportanceInterest in administering psychedelic agents as mental health treatment is growing rapidly. As drugmakers invest in developing psychedelic medicines for several psychiatric indications, lawmakers are enacting legal reforms to speed access globally, and health agencies are preparing to approve these treatments. Meanwhile, US states, such as Oregon and Colorado, are making psychedelics available
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Trajectories of Adolescent Media Use and Their Associations With Psychotic Experiences JAMA Psychiatry (IF 25.8) Pub Date : 2024-04-10 Vincent Paquin, Manuela Ferrari, Soham Rej, Michel Boivin, Isabelle Ouellet-Morin, Marie-Claude Geoffroy, Jai L. Shah
ImportanceAdolescent media use is thought to influence mental health, but whether it is associated with psychotic experiences (PEs) is unclear.ObjectiveTo examine longitudinal trajectories of adolescent media use and their associations with PEs at 23 years of age.Design, Setting, and ParticipantsThis cohort study included participants from the Québec Longitudinal Study of Child Development (1998-2021):
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Associations between multimorbidity and neuropathology in dementia: consideration of functional cognitive disorders, psychiatric illness and dementia mimics Br. J. Psychiatry (IF 10.5) Pub Date : 2024-04-08 Calum A. Hamilton, Fiona E. Matthews, Johannes Attems, Paul C. Donaghy, Daniel Erskine, John-Paul Taylor, Alan J. Thomas
Background Multimorbidity, the presence of two or more health conditions, has been identified as a possible risk factor for clinical dementia. It is unclear whether this is due to worsening brain health and underlying neuropathology, or other factors. In some cases, conditions may reflect the same disease process as dementia (e.g. Parkinson's disease, vascular disease), in others, conditions may reflect
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Tau pathology is associated with synaptic density and longitudinal synaptic loss in Alzheimer’s disease Mol. Psychiatry (IF 11.0) Pub Date : 2024-04-08 Jie Wang, Qi Huang, Xing Chen, Zhiwen You, Kun He, Qihao Guo, Yiyun Huang, Yang Yang, Zengping Lin, Tengfei Guo, Jun Zhao, Yihui Guan, Binyin Li, Fang Xie
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Towards precision in the diagnostic profiling of patients: leveraging symptom dynamics as a clinical characterisation dimension in the assessment of major depressive disorder Br. J. Psychiatry (IF 10.5) Pub Date : 2024-04-08 Omid V. Ebrahimi, Denny Borsboom, Ria H. A. Hoekstra, Sacha Epskamp, Edoardo G. Ostinelli, Jojanneke A. Bastiaansen, Andrea Cipriani
Background International guidelines present overall symptom severity as the key dimension for clinical characterisation of major depressive disorder (MDD). However, differences may reside within severity levels related to how symptoms interact in an individual patient, called symptom dynamics.Aims To investigate these individual differences by estimating the proportion of patients that display differences
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Glymphatic System Dysfunction Underlying Schizophrenia Is Associated With Cognitive Impairment Schizophr. Bull. (IF 6.6) Pub Date : 2024-04-06 Ye Tu, Yan Fang, Guohui Li, Fei Xiong, Feng Gao
Background and Hypothesis Despite the well-documented structural and functional brain changes in schizophrenia, the potential role of glymphatic dysfunction remains largely unexplored. This study investigates the glymphatic system’s function in schizophrenia, utilizing diffusion tensor imaging (DTI) to analyze water diffusion along the perivascular space (ALPS), and examines its correlation with clinical
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Adverse Events Reporting in Digital Interventions Evaluations for Psychosis: A Systematic Literature Search and Individual Level Content Analysis of Adverse Event Reports Schizophr. Bull. (IF 6.6) Pub Date : 2024-04-06 Stephanie Allan, Thomas Ward, Emily Eisner, Imogen H Bell, Matteo Cella, Imran B Chaudhry, John Torous, Tayyeba Kiran, Thomas Kabir, Aansha Priyam, Cara Richardson, Ulrich Reininghaus, Anita Schick, Matthias Schwannauer, Suzy Syrett, Xiaolong Zhang, Sandra Bucci
Background Digital health interventions (DHIs) have significant potential to upscale treatment access to people experiencing psychosis but raise questions around patient safety. Adverse event (AE) monitoring is used to identify, record, and manage safety issues in clinical trials, but little is known about the specific content and context contained within extant AE reports. This study aimed to assess
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Genetic influences and causal pathways shared between cannabis use disorder and other substance use traits Mol. Psychiatry (IF 11.0) Pub Date : 2024-04-05 Marco Galimberti, Daniel F. Levey, Joseph D. Deak, Hang Zhou, Murray B. Stein, Joel Gelernter
Cannabis use disorder (CanUD) has increased with the legalization of the use of cannabis. Around 20% of individuals using cannabis develop CanUD, and the number of users has grown with increasing ease of access. CanUD and other substance use disorders (SUDs) are associated phenotypically and genetically. We leveraged new CanUD genomics data to undertake genetically-informed analyses with unprecedented
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Social experience in adolescence shapes prefrontal cortex structure and function in adulthood Mol. Psychiatry (IF 11.0) Pub Date : 2024-04-05 Dan C. Li, Elizabeth A. Hinton, Jidong Guo, Kristopher A. Knight, Michelle K. Sequeira, Meghan E. Wynne, Niharika M. Dighe, Shannon L. Gourley
During adolescence, the prefrontal cortex (PFC) undergoes dramatic reorganization. PFC development is profoundly influenced by the social environment, disruptions to which may prime the emergence of psychopathology across the lifespan. We investigated the neurobehavioral consequences of isolation experienced in adolescence in mice, and in particular, the long-term consequences that were detectable
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Loss of mGlu5 receptors in somatostatin-expressing neurons alters negative emotional states Mol. Psychiatry (IF 11.0) Pub Date : 2024-04-04 Arnau Ramos-Prats, Pawel Matulewicz, Marie-Luise Edenhofer, Kai-Yi Wang, Chia-Wei Yeh, Ana Fajardo-Serrano, Michaela Kress, Kai Kummer, Cheng-Chang Lien, Francesco Ferraguti
Subtype 5 metabotropic glutamate receptors (mGlu5) are known to play an important role in regulating cognitive, social and valence systems. However, it remains largely unknown at which circuits and neuronal types mGlu5 act to influence these behavioral domains. Altered tissue- or cell-specific expression or function of mGlu5 has been proposed to contribute to the exacerbation of neuropsychiatric disorders
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Substance use and spine density: a systematic review and meta-analysis of preclinical studies Mol. Psychiatry (IF 11.0) Pub Date : 2024-04-02 Henrique Nunes Pereira Oliva, Tiago Paiva Prudente, Eric J. Nunes, Kelly P. Cosgrove, Rajiv Radhakrishnan, Marc N. Potenza, Gustavo A. Angarita
The elucidation of synaptic density changes provides valuable insights into the underlying brain mechanisms of substance use. In preclinical studies, synaptic density markers, like spine density, are altered by substances of abuse (e.g., alcohol, amphetamine, cannabis, cocaine, opioids, nicotine). These changes could be linked to phenomena including behavioral sensitization and drug self-administration
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Lost in Translation: Challenges for Translational Research in the Field of Stress and Cognition Biol. Psychiatry (IF 10.6) Pub Date : 2024-04-05 Israel Liberzon
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Correlation Between Cortical Thickness Abnormalities of the Olfactory Sulcus and Olfactory Identification Disorder and Persistent Auditory Verbal Hallucinations in Chinese Patients With Chronic Schizophrenia Schizophr. Bull. (IF 6.6) Pub Date : 2024-04-05 Honghong Ren, Zongchang Li, Jinguang Li, Jun Zhou, Ying He, Chunwang Li, Qianjin Wang, Xiaogang Chen, Jinsong Tang
Background and Hypothesis Persistent auditory verbal hallucinations (pAVHs) and olfactory identification impairment are common in schizophrenia (SCZ), but the neuroimaging mechanisms underlying both pAVHs and olfactory identification impairment are unclear. This study aimed to investigate whether pAVHs and olfactory identification impairment in SCZ patients are associated with changes in cortical thickness
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Distinct Volume Alterations of Thalamic Nuclei Across the Schizophrenia Spectrum Schizophr. Bull. (IF 6.6) Pub Date : 2024-04-05 Melissa Thalhammer, Julia Schulz, Felicitas Scheulen, Mohamed El Mehdi Oubaggi, Matthias Kirschner, Stefan Kaiser, André Schmidt, Stefan Borgwardt, Mihai Avram, Felix Brandl, Christian Sorg
Background and Hypothesis Abnormal thalamic nuclei volumes and their link to cognitive impairments have been observed in schizophrenia. However, whether and how this finding extends to the schizophrenia spectrum is unknown. We hypothesized a distinct pattern of aberrant thalamic nuclei volume across the spectrum and examined its potential associations with cognitive symptoms. Study Design We performed
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Patterns of stressful life events and polygenic scores for five mental disorders and neuroticism among adults with depression Mol. Psychiatry (IF 11.0) Pub Date : 2024-04-04 Jacob J. Crouse, Shin Ho Park, Enda M. Byrne, Brittany L. Mitchell, Jan Scott, Sarah E. Medland, Tian Lin, Naomi R. Wray, Nicholas G. Martin, Ian B. Hickie
The dominant (‘general’) version of the diathesis-stress theory of depression views stressors and genetic vulnerability as independent risks. In the Australian Genetics of Depression Study (N = 14,146; 75% female), we tested whether polygenic scores (PGS) for major depression, bipolar disorder, schizophrenia, anxiety, ADHD, and neuroticism were associated with reported exposure to 32 childhood, past-year
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Ketamine’s mechanism of action with an emphasis on neuroimmune regulation: can the complement system complement ketamine’s antidepressant effects? Mol. Psychiatry (IF 11.0) Pub Date : 2024-04-04 Brandi Quintanilla, Carlos A. Zarate, Anilkumar Pillai
Over 300 million people worldwide suffer from major depressive disorder (MDD). Unfortunately, only 30–40% of patients with MDD achieve complete remission after conventional monoamine antidepressant therapy. In recent years, ketamine has revolutionized the treatment of MDD, with its rapid antidepressant effects manifesting within a few hours as opposed to weeks with conventional antidepressants. Many
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Medicaid Reentry Section 1115 Demonstration Opportunity JAMA Psychiatry (IF 25.8) Pub Date : 2024-04-03 William C. Lieber, Jade Zhang, Lauren Brinkley-Rubinstein
This Viewpoint explains the Medicaid Reentry Section 1115 Demonstration Opportunity of April 2023 and recommends strategies to optimize this opportunity for community connection and mental health care.
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A Dynamical Systems View of Psychiatric Disorders—Theory JAMA Psychiatry (IF 25.8) Pub Date : 2024-04-03 Marten Scheffer, Claudi L. Bockting, Denny Borsboom, Roshan Cools, Clara Delecroix, Jessica A. Hartmann, Kenneth S. Kendler, Ingrid van de Leemput, Han L. J. van der Maas, Egbert van Nes, Mark Mattson, Pat D. McGorry, Barnaby Nelson
ImportancePsychiatric disorders may come and go with symptoms changing over a lifetime. This suggests the need for a paradigm shift in diagnosis and treatment. Here we present a fresh look inspired by dynamical systems theory. This theory is used widely to explain tipping points, cycles, and chaos in complex systems ranging from the climate to ecosystems.ObservationsIn the dynamical systems view, we
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Susceptibility to Treatment-Resistant Depression Within Families JAMA Psychiatry (IF 25.8) Pub Date : 2024-04-03 Chih-Ming Cheng, Mu-Hong Chen, Shih-Jen Tsai, Wen-Han Chang, Chia-Fen Tsai, Wei-Chen Lin, Ya-Mei Bai, Tung-Ping Su, Tzeng-Ji Chen, Cheng-Ta Li
ImportanceAntidepressant responses and the phenotype of treatment-resistant depression (TRD) are believed to have a genetic basis. Genetic susceptibility between the TRD phenotype and other psychiatric disorders has also been established in previous genetic studies, but population-based cohort studies have not yet provided evidence to support these outcomes.ObjectiveTo estimate the TRD susceptibility
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A Dynamical Systems View of Psychiatric Disorders—Practical Implications JAMA Psychiatry (IF 25.8) Pub Date : 2024-04-03 Marten Scheffer, Claudi L. Bockting, Denny Borsboom, Roshan Cools, Clara Delecroix, Jessica A. Hartmann, Kenneth S. Kendler, Ingrid van de Leemput, Han L. J. van der Maas, Egbert van Nes, Mark Mattson, Pat D. McGorry, Barnaby Nelson
ImportanceDynamical systems theory is widely used to explain tipping points, cycles, and chaos in complex systems ranging from the climate to ecosystems. It has been suggested that the same theory may be used to explain the nature and dynamics of psychiatric disorders, which may come and go with symptoms changing over a lifetime. Here we review evidence for the practical applicability of this theory