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Predicting survival in locally advanced rectal cancer with effective chemoradiotherapy response Eur. J. Surg. Oncol. (IF 3.8) Pub Date : 2024-04-20 Seijong Kim, Jung Wook Huh, Woo Yong Lee, Seong Hyeon Yun, Hee Cheol Kim, Yong Beom Cho, Yoonah Park, Jung Kyong Shin
Locally advanced rectal cancer patients often display favorable responses and favorable oncologic outcomes. Due to the low recurrence rate, there is scarcity of studies investigating the prognostic factors influencing their survival. Therefore, our study sought to assess the prognostic factors associated with survival in rectal cancer patients who achieved either a pathologic complete response or a
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Application value of a hybrid tracer during sentinel lymph node biopsy for head and neck malignancies: A systematic review and meta-analysis Eur. J. Surg. Oncol. (IF 3.8) Pub Date : 2024-04-20 Bowen Wang, Xingyue Ma, Xiao Zhang, Xiaoyan Zhang, Shuai Guan, Tiepeng Xiao, Xiangjun Li
To address the limitations of conventional sentinel lymph node biopsy (SLNB), a novel hybrid tracer (indocyanine green [ICG]-Tc-nanocolloid) has been developed. This meta-analysis aimed to compare the differences between the novel hybrid tracer and conventional methods using ICG or radioisotope (RI) for SLNB in head and neck malignancies. This study was registered in the International Prospective Register
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Predicting peritoneal recurrence after radical gastrectomy for gastric cancer: Validation of a prediction model (PERI-Gastric 1 and PERI-Gastric 2) on a Korean database Eur. J. Surg. Oncol. (IF 3.8) Pub Date : 2024-04-19 Francesco Belia, Ki-Yoon Kim, Annamaria Agnes, Sung Hyun Park, Minah Cho, Yoo Min Kim, Hyoung-Il Kim, Roberto Persiani, Domenico D'Ugo, Alberto Biondi, Woo Jin Hyung
Peritoneal recurrence is a significant cause of treatment failure after radical gastrectomy for gastric cancer. The prediction of metachronous peritoneal recurrence would have a significantly impact risk stratification and tailored treatment planning. This study aimed to externally validate the previously established PERI-Gastric 1 and 2 models to assess their generalizability in an independent population
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Localized colorectal cancer database integrating 4 randomized controlled trials; (JCOG2310A) Eur. J. Surg. Oncol. (IF 3.8) Pub Date : 2024-04-18 Kozo Kataoka, Akira Ouchi, Yusuke Suwa, Hidekazu Hirano, Toshifumi Yamaguchi, Yasuyuki Takamizawa, Marie Hanaoka, Kenta Iguchi, Shogen Boku, Ken Nagata, Taiji Koyama, Yasuhiro Shimada, Masafumi Inomata, Yusuke Sano, Junki Mizusawa, Tetsuya Hamaguchi, Yasumasa Takii, Shunsuke Tsukamoto, Atsuo Takashima, Yukihide Kanemitsu, JCOG Colorectal Cancer Study Group
Although phase III randomized controlled trials (RCTs) represent the most robust statistical approach for answering clinical questions, they require massive expenditures in terms of time, labor, and funding. Ancillary and supplementary analyses using RCTs are sometimes conducted as alternative approaches to answering clinical questions, but the available integrated databases of RCTs are limited. In
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Molecular biology of cholangiocarcinoma and its implications for targeted therapy in patient management Eur. J. Surg. Oncol. (IF 3.8) Pub Date : 2024-04-17 T.M. Gilbert, L. Randle, M. Quinn, O. McGreevy, L. O’leary, R. Young, R. Diaz-Neito, R.P. Jones, B. Greenhalf, C. Goldring, S. Fenwick, H. Malik, D.H. Palmer
Cholangiocarcinoma (CCA) remains a devastating malignancy and a significant challenge to treat. The majority of CCA patients are diagnosed at an advanced stage, making the disease incurable in most cases. The advent of high-throughput genetic sequencing has significantly improved our understanding of the molecular biology underpinning cancer. The identification of ‘druggable’ genetic aberrations and
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Functional Outcomes after Abdominal Surgery in Older Adults - How concerned are we about this? Eur. J. Surg. Oncol. (IF 3.8) Pub Date : 2024-04-17 Titus Hutch Jr Yi Zheng Yim, Kok Yang Tan
Amidst trends of a rapidly ageing population with better surgical outcomes for geriatric patients, it is imperative to consider outcome measures beyond mortality and morbidity rates. In fact, the preservation of one's postoperative function has been cited as a key priority for older adults and is a crucial determinant of postoperative independence and survival. This review aims to examine the prevalence
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Charting connections: A systematic review of colorectal surgery research networks Eur. J. Surg. Oncol. (IF 3.8) Pub Date : 2024-04-17 Jacopo Crippa, Carmelo Magistro, Isacco Montroni, Giacomo Borroni, Antonio Ziccarelli, Antonino Spinelli, Giulio Maria Mari, AIMS Academy Clinical Research Network
Research in surgery faces intrinsic difficulties such as the lack of reproducibility of surgical operations, self-referring surgeons, decentralized data. Establishing a community of qualified researchers across surgeons is crucial. Clinical networks have been proposed as solutions to many challenges in surgical research, yet their implementation remains uncommon, especially for surgical trialists.
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“Unveiling controversies: The role of HIPEC in colorectal cancer peritoneal metastasis" Eur. J. Surg. Oncol. (IF 3.8) Pub Date : 2024-04-16 Hasnain Wajeeh us Saqib, Ali Abdullah, Abdul Majid
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Congenital and gynecological tumors: A review Eur. J. Surg. Oncol. (IF 3.8) Pub Date : 2024-04-16 Shady A. Saleem, Fatma El-Zahraa A. Mustafa, Hanan H. Abd-Elhafeez, Gilan A. Ahmed
Congenital tumors are rare, and malignant congenital tumors are uncommon. Benign tu,mors might be life-threatening, depending on the location and size of the tumor. Different factors affect congenital tumors, such as maternal and placental hormones and environmental factors such as drugs, radiation, and infection. Developing fetal imaging methods and continuous follow-up during pregnancy are important
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Time trend of breast cancer-related lymphedema according to body mass index Eur. J. Surg. Oncol. (IF 3.8) Pub Date : 2024-04-16 Akiko Ogiya, Kiyomi Kimura, Takayuki Ueno, Takuji Iwase, Shinji Ohno
To clarify how body mass index (BMI) affects the development and temporal trend of breast cancer-related lymphedema (BCRL). This is a prospective study in which patients with operable breast cancer were registered in a single institute between November 2009 and July 2010. The incidence of lymphedema at 1, 3, and 5 years after surgery was assessed according to BMI, and the trend of newly developed BCRL
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Long-term follow-up of non-myasthenic patients with early-stage thymoma who underwent extended thymectomy or limited resection Eur. J. Surg. Oncol. (IF 3.8) Pub Date : 2024-04-16 Ping-Chung Tsai, Yen-Chiang Tseng, Ying-Che Ting, Chien-Sheng Huang, Wen-Hu Hsu, En-Kuei Tang, Han-Shui Hsu
The standard resection for early-stage thymoma is total thymectomy and complete tumour excision with or without myasthenia gravis but the optimal surgery mode for patients with early-stage non-myasthenic thymoma is debatable. This study analysed the oncological outcomes for non-myasthenic patients with early-stage thymoma treated by thymectomy or limited resection in the long term. Patients who had
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Impact of pCR after neoadjuvant chemotherapy and radical D2 dissection in locally advanced gastric cancers: Analysis of 1001 cases Eur. J. Surg. Oncol. (IF 3.8) Pub Date : 2024-04-16 Manish S. Bhandare, Kaival K. Gundavda, Raghav Yelamanchi, Amit Chopde, Swati Batra, Manjushree Kolhe, Anant Ramaswamy, Vikas Ostwal, Kedar Deodhar, Vikram Chaudhari, Shailesh V. Shrikhande
Advances in perioperative chemotherapy have improved outcomes in patients with gastric cancers (GC). This strategy leads to tumour downstaging and may result in a pathologic complete response (pCR). The study aimed to evaluate the predictors of pCR and determine the impact of pCR on long-term survival. At the Department of Gastrointestinal and HPB Oncology at the Tata Memorial Centre, Mumbai, 1001
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Impact of mesorectal extranodal tumor deposits in magnetic resonance imaging on outcome of rectal cancer patients Eur. J. Surg. Oncol. (IF 3.8) Pub Date : 2024-04-16 Suvi T. Marjasuo, Tiina E. Lehtimäki, Laura E. Koskenvuo, Anna H. Lepistö
Mesorectal extranodal tumor deposits (TDs) are identified in many rectal cancers. Their radiological features differ from metastatic lymph nodes, and they can be detected with magnetic resonance imaging (MRI). The purpose of this study was to determine the prevalence of rectal cancer TDs detected with MRI and their impact on overall (OS), cancer-specific (CSS), and disease-free survival (DFS) and the
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Long-term clinical outcomes of preoperative brachytherapy in early-stage cervical cancer Eur. J. Surg. Oncol. (IF 3.8) Pub Date : 2024-04-16 C. Buchalet, P. Loap, S. Losa, E. Laas, T. Gaillard, F. Lecuru, C. Malhaire, V. Huchet, A. De La Rochefordiere, A. Labib, M. Kissel
The treatment of early-stage cervical cancer (CC) is primarily based on surgery. Adjuvant (chemo)radiotherapy can be necessary in presence of risk factors for relapse (tumor size, deep stromal invasion, lymphovascular space invasion (LVSI), positive margins, parametrial or lymph node involvement), increasing the risk of treatment toxicity. Preoperative brachytherapy can reduce tumor extension before
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Diagnostic yield of cone beam CT based navigation bronchoscopy in patients with metastatic lesions: A propensity score matched case-control study Eur. J. Surg. Oncol. (IF 3.8) Pub Date : 2024-04-15 Marta Viscuso, Roel L.J. Verhoeven, Stephan E.P. Kops, Gerjon Hannink, Rocco Trisolini, Erik H.F.M. van der Heijden
Cone beam CT based Navigation Bronchoscopy (CBCT-NB) has predominantly been investigated as a diagnostic tool in (suspected) primary lung cancers. Small metastatic lesions are clinically considered more challenging to diagnose, but no study has explored the yield of navigation bronchoscopy in patients with pulmonary metastatic lesions (ML) compared to primary lung cancers (PL), correcting for known
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Hyperspectral and multispectral imaging in neurosurgery: a systematic literature review and meta-analysis Eur. J. Surg. Oncol. (IF 3.8) Pub Date : 2024-04-12 Giulio Anichini, Maria Leiloglou, Zepeng Hu, Kevin O'Neill, Daniel Elson
The neuro-surgical community is witnessing a rising interest for surgical application of multispectral/hyperspectral imaging. Several potential technical applications of this optical imaging are reported, but the set-up is variable and so are the processing methods. We present a systematic review of the relevant literature on the topic. A literature search based on the PRISMA principles was performed
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Minor hepatectomy combined with cholangioplasty and cholangiojejunostomy for Bismuth II hilar cholangiocarcinoma: A propensity score matching analysis Eur. J. Surg. Oncol. (IF 3.8) Pub Date : 2024-04-12 Jun Yang, Zixuan Fu, Weiwei Sheng, Zhihao Huang, Jiandong Peng, Pengcheng Zhou, Jianghui Xiong, Rongshou Wu, Wenjun Liao, Linquan Wu, Enliang Li
The optimal surgical approach for Bismuth II hilar cholangiocarcinoma (HCCA) remains controversial. This study compared perioperative and oncological outcomes between minor and major hepatectomy. One hundred and seventeen patients with Bismuth II HCCA who underwent hepatectomy and cholangiojejunostomy between January 2018 and December 2022 were retrospectively investigated. Propensity score matching
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Timing of genetic testing in BRCA1/2 and PALB2-Associated breast cancer: Preoperative result disclosure increases uptake of risk-reducing mastectomy and reduces unnecessary exposure to radiotherapy Eur. J. Surg. Oncol. (IF 3.8) Pub Date : 2024-04-12 Carla Apostolova, Amina Ferroum, Basmah Alhassan, Ipshita Prakash, Mark Basik, Jean Francois Boileau, Karyne Martel, Sarkis Meterissian, Victor Villareal Corpuz, Nora Wong, William D. Foulkes, Stephanie M. Wong
The impact of timing of genetic testing on uptake of risk reducing mastectomy (RRM) in affected female or carriers remains an area of evolving interest, particularly with the introduction of mainstream genetic testing initiatives. Women with stage I-III breast cancer and a confirmed germline pathogenic variant in or between 2000 and 2023 were identified from an institutional genetics database. Uptake
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A restrictive stoma policy after colorectal anastomosis in ovarian cancer based on ghost ileostomy use Eur. J. Surg. Oncol. (IF 3.8) Pub Date : 2024-04-11 Víctor Lago, Manel Montesinos Albert, Marta Arnaez Cruz, Rafael Alberto Guijarro Campillo, Pablo Padilla-Iserte, Luis Matute, Marta Gurrea, Blas Flor, Santiago Domingo
The incidence of anastomotic leak after colorectal anastomosis in ovarian cancer has been reported to be much lower than that in colorectal cancer patients. Regarding the use of protective manoeuvres (diverting ileostomy) as suggested by clinical guidelines, the goal should be the implementation of a restrictive stoma policy for ovarian cancer patients, given the low rate of anastomotic leakage in
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Challenging the Dogma: Stage migration or negative lymph nodes, which of them is the main player on gastric cancer prognosis? Eur. J. Surg. Oncol. (IF 3.8) Pub Date : 2024-04-11 P. Matos da Costa, Cláudia Antunes, Patrícia Lages, Jéssica Rodrigues, Mariana Peyroteo, Susana Onofre, Lúcio Lara Santos
Expanding loco-regional nodes harvesting is expected to increase survival. This improvement may be associated to stage migration (SM). However, the great bulk of harvested lymph nodes observed in large dissections is negative. 830 patients who received R0 gastrectomy for adenocarcinoma were included. pN+ patients with <26 nodes (n = 209) were included for a simulation to “offer 26 nodes” - SM (proportional
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Treatment of anterior resection syndrome: A systematic review and network meta-analysis Eur. J. Surg. Oncol. (IF 3.8) Pub Date : 2024-04-10 Lu Zhou, Zhengyang Zhang, Ling Wang
There has been a lack of research comparing the efficacy of various treatments for low anterior resection syndrome (LARS). We conducted a comprehensive search across six electronic databases and a paired meta-analysis was undertaken to assess the effectiveness of the interventions. Furthermore, a network meta-analysis was utilized to compare the efficacy of different treatments for LARS. This study
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Clinical significance of geriatric nutritional risk index in esophageal squamous cell carcinoma receiving neoadjuvant immunotherapy Eur. J. Surg. Oncol. (IF 3.8) Pub Date : 2024-04-08 Jifeng Feng, Liang Wang, Xun Yang, Qixun Chen, Xiangdong Cheng
The geriatric nutritional risk index (GNRI) is a novel nutrition-related indicator designed to predict the risk of clinical outcomes in various cancers. The clinical significance of risk assessment, therapeutic response, and prognostic prediction of GNRI in esophageal squamous cell carcinoma (ESCC) receiving neoadjuvant immunochemotherapy (NICT), a hot point of treatment these days, have not been documented
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Development and validation of a novel nomogram for predicting overall survival patients with neuroblastoma Eur. J. Surg. Oncol. (IF 3.8) Pub Date : 2024-04-06 Jin-du Zhao, Xian-ying Lu, Tian-ping Chen, Xian-Lun Duan, Wei Zuo, Kai Sai, Li-ran Zhu, Qun Gao
The aim of this study was to develop a nomogram specially for predicting overall survival (OS) for Chinese patients with neuroblastoma (NB). Patients with pathologically confirmed NB who were newly diagnosed and received treatments at our hospital from October 2013 to October 2021 were retrospectively reviewed. The nomogram for OS were built based on Cox regression analysis. The validation of the prognostic
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Development of a prediction model for recurrence in patients with colorectal peritoneal metastases undergoing cytoreductive surgery with hyperthermic intraperitoneal chemotherapy Eur. J. Surg. Oncol. (IF 3.8) Pub Date : 2024-04-04 Michelle V. Dietz, Gerjon Hannink, Ibrahim Said, Femke A. van der Zant, Vincent C.J. van de Vlasakker, Alexandra R.M. Brandt-Kerkhof, Cornelis Verhoef, Andreas J.A. Bremers, Johannes H.W. de Wilt, Patrick H.J. Hemmer, Ignace H.J.T. de Hingh, Philip R. de Reuver, Eva V.E. Madsen
Cytoreductive surgery (CRS) with hyperthermic intraperitoneal chemotherapy (HIPEC) improves survival outcomes for selected patients with colorectal peritoneal metastases (PM), but recurrence rates are high. The aim of this study was to develop a tool to predict recurrence in patients with colorectal PM that undergo CRS-HIPEC. For this retrospective cohort study, data of patients that underwent CRS-HIPEC
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Intraoperative frozen section of subareolar tissue in nipple-sparing mastectomy: Towards a less is more approach Eur. J. Surg. Oncol. (IF 3.8) Pub Date : 2024-04-03 Jonathan Spoor, Eva Heeling, Romy C. Collewijn, Iris M.C. van der Ploeg, Marije J. Hoornweg, Nicola Russell, Jose G. van den Berg, Marie-Jeanne F.T.D. Vrancken Peeters, Frederieke H. van Duijnhoven
Nipple preservation contributes to aesthetic outcome and quality of life in women undergoing Skin-Sparing Mastectomy (SSM) with immediate breast reconstruction for the treatment of breast cancer. Intraoperative Frozen Section (IFS) has been advocated to facilitate conversion from Nipple-Sparing Mastectomy (NSM) to SSM in cases with positive subareolar margins. This study investigated the application
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Impact of neoadjuvant chemotherapy on short-term outcomes after simple and complex minimally invasive minor hepatectomy for colorectal liver metastases: A propensity-score matched and coarsened exact matched study Eur. J. Surg. Oncol. (IF 3.8) Pub Date : 2024-04-02 Tijs J. Hoogteijling, Mohammad Abu Hilal, Giuseppe Zimmitti, Davit L. Aghayan, Andrew G.R. Wu, Federica Cipriani, Salvatore Gruttadauria, Olivier Scatton, Tran Cong duy Long, Paulo Herman, Marco V. Marino, Vincenzo Mazzaferro, Adrian K.H. Chiow, Iswanto Sucandy, Arpad Ivanecz, Sung Hoon Choi, Jae Hoon Lee, Mikel Gastaca, Marco Vivarelli, Felice Giuliante, Andrea Ruzzenente, Chee Chien Yong, Mengqiu
In the last three decades, minimally invasive liver resection has been replacing conventional open approach in liver surgery. More recently, developments in neoadjuvant chemotherapy have led to increased multidisciplinary management of colorectal liver metastases with both medical and surgical treatment modalities. However, the impact of neoadjuvant chemotherapy on the surgical outcomes of minimally
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Is early continence recovery related to the length of spared urethra? A prospective multicenter study comparing preoperative MRI and histologic specimen measurements after robotic radical prostatectomy Eur. J. Surg. Oncol. (IF 3.8) Pub Date : 2024-04-02 Fabio Maria Valenzi, Andrea Fuschi, Yazan Al Salhi, Manfredi Bruno Sequi, Paolo Pietro Suraci, Matteo Pacini, Silvio Scalzo, Onofrio Antonio Rera, Alice Antonioni, Damiano Graziani, Giorgio Martino, Giuseppe Candita, Filippo Gianfrancesco, Alessandro Zucchi, Riccardo Lombardo, Cosimo De Nunzio, Antonio Cicione, Giorgio Bozzini, Marco Rengo, Paola Capodiferro, Alessandro Sciarra, Vincenzo Petrozza,
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Robotic beyond total mesorectal excision for locally advanced rectal cancers: Perioperative and oncological outcomes from a multicentre case series Eur. J. Surg. Oncol. (IF 3.8) Pub Date : 2024-04-02 Jim S. Khan, Guglielmo Niccolò Piozzi, Philippe Rouanet, Avanish Saklani, Volkan Ozben, Paul Neary, Peter Coyne, Seon Hahn Kim, Julio Garcia-Aguilar
Around 20% of rectal tumors are locally advanced with invasion into adjacent structures at presentation. These may require surgical resections beyond boundaries of total mesorectal excision (bTME) for radicality. Robotic bTME is under investigation. This study reports perioperative and oncological outcomes of robotic bTME for locally advanced rectal cancers. A multicentre, retrospective analysis of
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Is it safe to operate selected low-risk endometrial cancer patients in secondary hospitals? Eur. J. Surg. Oncol. (IF 3.8) Pub Date : 2024-04-01 Sara Narva, Päivi Polo-Kantola, Sinikka Oksa, Johanna Kallio, Jutta Huvila, Tiia Rissanen, Johanna Hynninen, Sakari Hietanen, Titta Joutsiniemi
The aim of this study was to assess the accuracy of a preoperative screening algorithm in identifying low-risk endometrial cancer (EC) patients to ensure optimal care. A total of 277 patients with primary EC confirmed through biopsy underwent magnetic resonance imaging (MRI). Patients with risk factors for advanced high-risk EC, such as non-endometrioid histology, high-grade differentiation status
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Ovarian cancer care in Belgium: The elephant in the country Eur. J. Surg. Oncol. (IF 3.8) Pub Date : 2024-03-30 Wiebren Tjalma
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Variability of treatment of locally advanced cervical cancer: How French multidisciplinary teams follow European guidelines? Eur. J. Surg. Oncol. (IF 3.8) Pub Date : 2024-03-29 Jonathan Sabah, Ines Menoux, Lauriane Eberst, Massimo Lodi, Justine Gantzer, Henri Azais, Houssein El Hajj, Vincent Balaya, Guillaume Babin, Sophie Espenel, Yohann Dabi, Manon Kissel, Tran Phuong Lien, Martina Aida Angeles, Francois Margueritte, Elise Deluche, Alexis Marouk, Pierrick Le Borgne, Mah-Soune Apithy, Enora Laas-Faron, Chérif Akladios, Lise Lecointre, For SFOG Campus: Societe Française d’Oncologie
Cervical cancer is a global public health concern. Despite ESGO recommendations and FIGO classification changes, management of locally advanced cervical cancer (LACC) remains debated in France. Our study aimed to review LACC treatment practices and assess adherence to ESGO recommendations among different practitioners. From February 2021 to August 2022, we conducted a survey among gynecologic oncology
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Prognostic significance of MRI-detected extramural venous invasion according to grade and response to neo-adjuvant treatment in locally advanced rectal cancer A national cohort study after radiologic training and reassessment Eur. J. Surg. Oncol. (IF 3.8) Pub Date : 2024-03-29 Eline G.M. van Geffen, Joost Nederend, Tania C. Sluckin, Sanne-Marije J.A. Hazen, Karin Horsthuis, Regina G.H. Beets-Tan, Corrie A.M. Marijnen, Pieter J. Tanis, Miranda Kusters, the Dutch Snapshot Research Group, Arend G.J. Aalbers, Susanna M. van Aalten, Femke J. Amelung, Marjolein Ankersmit, Imogeen E. Antonisse, Jesse F. Ashruf, Tjeerd S. Aukema, Henk Avenarius, Renu R. Bahadoer, Frans C.H. Bakers
Detection of grade 3–4 extra mural venous invasion (mrEMVI) on magnetic resonance imaging (MRI) is associated with an increased distant metastases (DM)-rate. This study aimed to determine the impact of different grades of mrEMVI and their disappearance after neoadjuvant therapy. A Dutch national retrospective cross-sectional study was conducted, including patients who underwent resection for rectal
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BRAF mutations and survival with surgery for colorectal liver metastases: A systematic review and meta-analysis Eur. J. Surg. Oncol. (IF 3.8) Pub Date : 2024-03-29 Fausto Petrelli, Marcella Arru, Silvia Colombo, Matteo Cavallone, Fulvia Milena Cribiu’, Viola Villardita, Paola Floris, Luciano Digiesi, Gabriele Severgnini, Mariana Teixeira Moraes, Barbara Conti, Andrea Celotti, Matteo Viti, Andrea Sozzi
Mutations in the BRAF gene (BRAFmut) are associated with an unfavorable prognosis in patients with metastatic colorectal cancer (CRC). The aim of this meta-analysis was to evaluate the prognosis of colorectal cancer (CRC) patients with liver metastases and the potential benefits of liver resection in patients with BRAFmut CRC. A systematic search of PubMed, Cochrane Central Controlled Trials, and Embase
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Perineural invasion in cervical cancer: A multicenter retrospective study Eur. J. Surg. Oncol. (IF 3.8) Pub Date : 2024-03-28 Xiaolin Chen, Hui Duan, Hongwei Zhao, Fangjie He, Lu Yin, Yueping Liu, Lixia Wang, Chunlin Chen
The study aimed to evaluate the accuracy of perineural invasion (PNI) diagnosis in cervical cancer, and to analyze the impact of PNI on the prognosis and postoperative adjuvant treatment decisions for cervical cancer. A retrospective pathological review of PNI in cervical cancer was conducted from 2004 to 2016 in 15 hospitals. This study included a total of 1208 cases, comprising 273 cases with PNI
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Prognostic impact of positive microscopic margins (R1 resection) in patients with GIST (gastrointestinal stromal tumours): Results of a multicenter European study Eur. J. Surg. Oncol. (IF 3.8) Pub Date : 2024-03-28 Flore Thibaut, Julie Veziant, Maxime Warlaumont, Victoria Gauthier, Jérémie Lefèvre, Caroline Gronnier, Stephane Bonnet, Jean-Yves Mabrut, Jean-Marc Regimbeau, Léonor Benhaim, G.A.M. Tiberio, Muriel Mathonnet, Nicolas Regenet, Mircea Chirica, Olivier Glehen, Pascale Mariani, Yves Panis, Laurent Genser, Didier Mutter, Jérémie Théreaux, Damien Bergeat, Bertrand Le Roy, Cécile Brigand, Clarisse Eveno
Although several prognostic factors in GIST have been well studied such as tumour size, mitotic rate, or localization, the influence of microscopic margins or R1 resection remains controversial. The aim of this study was to evaluate the influence of R1 resection on the prognosis of GIST in a large multicentre retrospective series of patients. From 2001 to 2013, 1413 patients who underwent surgery for
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Perioperative complications and in-hospital mortality in radical cystectomy patients with heart-valve replacement Eur. J. Surg. Oncol. (IF 3.8) Pub Date : 2024-03-28 Carolin Siech, Andrea Baudo, Mario de Angelis, Letizia Maria Ippolita Jannello, Francesco Di Bello, Jordan A. Goyal, Zhe Tian, Fred Saad, Shahrokh F. Shariat, Nicola Longo, Luca Carmignani, Ottavio de Cobelli, Alberto Briganti, Marina Kosiba, Philipp Mandel, Luis A. Kluth, Felix K.H. Chun, Pierre I. Karakiewicz
To assess in-hospital mortality and complication rates after radical cystectomy (RC) in patients with history of heart-valve replacement. Using the National Inpatient Sample (2000–2019), non-metastatic bladder cancer patients undergoing RC were stratified according to history of heart-valve replacement. Regression models (RM) predicted hospital outcomes. Of 25,535 RC patients, 250 (1.0%) harbored history
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Towards standardized terminology for patients with synchronous colorectal cancer and liver metastases Eur. J. Surg. Oncol. (IF 3.8) Pub Date : 2024-03-28 H.Z. Malik, A.K. Siriwardena
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The importance of preclinical models in cholangiocarcinoma Eur. J. Surg. Oncol. (IF 3.8) Pub Date : 2024-03-27 Owen McGreevy, Mohammed Bosakhar, Timothy Gilbert, Marc Quinn, Stephen Fenwick, Hassan Malik, Christopher Goldring, Laura Randle
Cholangiocarcinoma (CCA) is an adenocarcinoma of the hepatobiliary system with a grim prognosis. Incidence is rising globally and surgery is currently the only curative treatment, but is only available for patients who are fit and diagnosed in an early-stage of disease progression. Great importance has been placed on developing preclinical models to help further our understanding of CCA and potential
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Ethical and legal issues regarding artificial intelligence (AI) and management of surgical data Eur. J. Surg. Oncol. (IF 3.8) Pub Date : 2024-03-27 Alberto R. Ferreres
The advent of AI in surgical practice is representing a major innovation. As its role expands and due to its several implications, strict compliance with ethical, legal and regulatory good practices is mandatory. Observance of ethical principles and legal rules will be a professional imperative for the application of AI in surgical practice, both clinically and scientifically.
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Reply to: Does esophageal cancer surgery have similar long-term oncological outcomes in different weekday? Eur. J. Surg. Oncol. (IF 3.8) Pub Date : 2024-03-26 Peinan Chen, Xianben Liu, Xiaocan Jia
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Whether clinical staging is more suitable for the affect of surgical complications on survival after neoadjuvant therapy? Eur. J. Surg. Oncol. (IF 3.8) Pub Date : 2024-03-26 Kexun Li, Xiaobo Chen, Jiapeng Yang
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Response to: Whether clinical staging is more suitable for the affect of surgical complications on survival after neoadjuvant therapy? Eur. J. Surg. Oncol. (IF 3.8) Pub Date : 2024-03-25 Jakub Chmelo, Edward J. Nevins, Alexander W. Phillips
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Are biomarkers expression and clinical-pathological factors predictive markers of the efficacy of neoadjuvant chemotherapy for locally advanced cervical cancer? Eur. J. Surg. Oncol. (IF 3.8) Pub Date : 2024-03-25 Antonino Ditto, Mariangela Longo, Giulia Chiarello, Luigi Mariani, Biagio Paolini, Umberto Leone Roberti Maggiore, Fabio Martinelli, Giorgio Bogani, Francesco Raspagliesi
To predict the overall pathologic response to neoadjuvant chemotherapy (NACT) of patients with locally advanced cervical cancer (LACC) creating a prediction model based on clinical-pathological factors and biomarkers (p53, Bcl1 and Bcl2) and to evaluate the prognostic outcomes of NACT. This is a retrospective study of 88 consecutive patients with LACC who underwent NACT followed by nerve sparing surgery
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A prediction model for lung metastases in patients with indeterminate pulmonary nodules in newly diagnosed colorectal cancer Eur. J. Surg. Oncol. (IF 3.8) Pub Date : 2024-03-25 Brigitha W. Nuijens, Robert Lindeboom, Joris J. van den Broek, Remy W.F. Geenen, Wilhelmina H. Schreurs
Multidisciplinary teams treating patients with newly diagnosed Colorectal Cancer (CRC) often encounter the appearance of Indeterminate Pulmonary Nodules (IPNs) that warrants follow–up with repetitive medical imaging and anxiety for patients. We determined the incidence of IPNs in patients with newly diagnosed CRC and developed and validated a model for individualized risk prediction of IPNs being lung
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Presenting embryologically defined peripancreatic compartments and fusion planes in the search for pancreatic cancer fields Eur. J. Surg. Oncol. (IF 3.8) Pub Date : 2024-03-24 Athanasios Alvanos, Ingo Bechmann, Hanno Steinke
Clinical progress in form of “total mesometrial resection” (TMMR) in cervical cancer and “total mesorectal excision” (TME) in rectal cancer can be traced to a paradigm-shift regarding the extent and range of resection. More significance is bestowed upon embryologically defined borders which define compartments, “morphogenetic units” and “cancer fields”, that have to be addressed in order to avoid incomplete
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Does esophageal cancer surgery have similar long-term oncological outcomes in different weekday? Eur. J. Surg. Oncol. (IF 3.8) Pub Date : 2024-03-24 Kexun Li, Jiapeng Yang, Yunchao Huang
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Preoperative detection of hepatocellular carcinoma's microvascular invasion on CT-scan by machine learning and radiomics: A preliminary analysis Eur. J. Surg. Oncol. (IF 3.8) Pub Date : 2024-03-24 Simone Famularo, Camilla Penzo, Cesare Maino, Flavio Milana, Riccardo Oliva, Jacques Marescaux, Michele Diana, Fabrizio Romano, Felice Giuliante, Francesco Ardito, Gian Luca Grazi, Matteo Donadon, Guido Torzilli
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Textbook oncological outcomes and prognosis after curative gastrectomy in advanced gastric cancer: A multicenter study Eur. J. Surg. Oncol. (IF 3.8) Pub Date : 2024-03-21 Ze-Ning Huang, Chang-Yue Zheng, Ju Wu, Yi-Hui Tang, Wen-Wu Qiu, Qi-Chen He, Guo-Sheng Lin, Qi-Yue Chen, Jun Lu, Jia-Bin Wang, Long-Long Cao, Mi Lin, Ru-Hong Tu, Jian-Wei Xie, Ping Li, Wei Lin, Chang-Ming Huang, Jian-Xian Lin, Chao-Hui Zheng
The impact of achieving textbook oncological outcome (TOO) as a multimodal therapy quality indicator on the prognosis of advanced gastric cancer (AGC) remains inadequately assessed. Patients with AGC who underwent curative gastrectomy between January 2010 and December 2017 at two East Asian medical centers were included. TOO was defined as achieving the textbook outcome (TO) and receiving neoadjuvant
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Multimodal prehabilitation in elective oncological colorectal surgery enhances postoperative functional recovery: A secondary analysis of the PREHAB randomized clinical trial Eur. J. Surg. Oncol. (IF 3.8) Pub Date : 2024-03-20 David W.G. ten Cate, Charlotte J.L. Molenaar, Raquel Sebio Garcia, Rasmus D. Bojesen, Bhagya Lakshmi Ramappa Tahasildar, Loes Jansen, Manuel López-Baamonde, Carlo Vittorio Feo, Graciela Martínez-Palli, Ismail Gögenur, Francesco Carli, Gerrit D. Slooter, PREHAB study group
Colorectal cancer (CRC) ranks as the second leading cause of cancer-related deaths. The PREHAB trial revealed that prehabilitation in colorectal surgery leads to a reduction of severe complications and enhanced functional capacity. Nevertheless, risk selection for prehabilitation and the potential benefits for patients without postoperative complications remains unclear. This study aims to assess postoperative
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Staging laparoscopy in gastric cancer patients: From a Dutch nationwide Delphi consensus towards a standardized protocol Eur. J. Surg. Oncol. (IF 3.8) Pub Date : 2024-03-19 Karen van der Sluis, Niels A.D. Guchelaar, Lianne Triemstra, Ron H.J. Mathijssen, Jelle P. Ruurda, Bas P.L. Wijnhoven, Johanna W. van Sandick, on behalf of the Collaborators, M.I. van Berge Henegouwen, S.S. Gisbertz, W.J. Eshuis, F. Daams, W.A. Borstlap, M.D.P. Luyer, G.A. Simkens, G.A.P. Nieuwenhuizen, P.C. van der Sluis, S.M. Lagarde, B.J. Noordman, J. Heisterkamp, R.A. Matthijsen, E.P.C. Matthée
Staging laparoscopy is a common diagnostic tool in gastric cancer, but its performance varies widely. The aim of this study was to gain Dutch nationwide consensus regarding the indications for and execution of staging laparoscopy in patients with gastric cancer. All surgeons in the Netherlands specialized in gastric cancer surgery (n = 52) were asked to participate in a Delphi consensus study. The
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Omission of breast surgery in selected breast cancer patients with excellent response to neoadjuvant systemic therapy Eur. J. Surg. Oncol. (IF 3.8) Pub Date : 2024-03-19 Marios-Konstantinos Tasoulis, Samantha Muktar, Ian Smith, Nicola Roche, Fiona MacNeill
Modern neoadjuvant systemic therapy (NST) can result in high pathologic complete response rates (pCR) in triple negative (TN) and human epidermal growth factor receptor 2 positive (HER2+) breast cancer. The role of surgery is, therefore, being reconsidered in this rapidly evolving field. This report presents oncological outcomes of seven patients with TN or HER2+ breast cancer, with exceptional response
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Comment on “Management of 80 sinonasal undifferentiated carcinomas. Retrospective multicentre study of the French Network of Rare Head and Neck Cancers (REFCOR). https://doi.org/10.1016/j.ejso.2023.107108.” Eur. J. Surg. Oncol. (IF 3.8) Pub Date : 2024-03-19 Erkan Topkan, Efsun Somay, Ugur Selek
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Factors associated with one-year mortality after curative surgery for primary clinical T4 and locally recurrent rectal cancer in elderly patients Eur. J. Surg. Oncol. (IF 3.8) Pub Date : 2024-03-19 Nikki C.M. van Ham, Sofie Glazemakers, Mirjam van der Ende-van Loon, Grard A.P. Nieuwenhuijzen, Harm J.T. Rutten, Jip L. Tolenaar, Anne Jacobs, Jacobus W.A. Burger, Stijn H.J. Ketelaers, Johanne G. Bloemen
Despite advancements in colorectal cancer care, one-year post-operative mortality rates remain high for elderly patients who have undergone curative surgery for primary clinical T4 rectal cancer (cT4RC) or locally recurrent rectal cancer (LRRC). This study aimed to identify factors associated with one-year mortality and to evaluate the causes of death. This retrospective cohort study included patients
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Technical and functional design considerations for a real-world interpretable AI solution for NIR perfusion analysis (including cancer) Eur. J. Surg. Oncol. (IF 3.8) Pub Date : 2024-03-18 A. Moynihan, P. Boland, J. Cucek, S. Erzen, N. Hardy, P. McEntee, J. Rojc, R. Cahill
Near infrared (NIR) analysis of tissue perfusion via indocyanine green fluorescence assessment is performed clinically during surgery for a range of indications. Its usefulness can potentially be further enhanced through the application of interpretable artificial intelligence (AI) methods to improve dynamic interpretation accuracy in these and also open new applications. While its main use currently
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Enhanced accuracy and reduced delay in diagnosing bone tumors within an expert sarcoma network: A nationwide study Eur. J. Surg. Oncol. (IF 3.8) Pub Date : 2024-03-18 Vincent Crenn, François Lataste, Louise Galmiche, Louis-Romée Le Nail, Mickaël Ropars, Jean-Yves Blay, Gonzague de Pinieux, Francois Gouin
Primary bone tumors encompass a range of rare and diverse lesions. Pathological diagnosis poses significant challenges, with histological discrepancies extensively studied in soft tissue sarcomas but lacking specific investigation in bone lesions. This study aimed to determine the rate of major diagnostic discrepancies in primary bone tumors, assessing whether initial histological analysis within an
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Outcomes of liver surgery: A decade of mandatory nationwide auditing in the Netherlands Eur. J. Surg. Oncol. (IF 3.8) Pub Date : 2024-03-16 Michelle R. de Graaff, Joost M. Klaase, Marcel den Dulk, C.I. Buis, Wouter J.M. Derksen, Jeroen Hagendoorn, Wouter K.G. Leclercq, Mike S.L. Liem, Henk H. Hartgrink, Rutger-Jan Swijnenburg, M. Vermaas, Eric J. Th Belt, Koop Bosscha, Cees Verhoef, Steven Olde Damink, Koert Kuhlmann, H.M. Marsman, Ninos Ayez, Peter van Duijvendijk, Peter van den Boezem, Eric R. Manusama, Dirk J. Grünhagen, Niels F.M.
In 2013, the nationwide Dutch Hepato Biliary Audit (DHBA) was initiated. The aim of this study was to evaluate changes in indications for and outcomes of liver surgery in the last decade. This nationwide study included all patients who underwent liver surgery for four indications, including colorectal liver metastases (CRLM), hepatocellular carcinoma (HCC), and intrahepatic– and perihilar cholangiocarcinoma
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Long-term outcomes of endoscopic therapy versus surgical resection for 2–5 cm gastric gastrointestinal stromal tumors: A population-based comparative study Eur. J. Surg. Oncol. (IF 3.8) Pub Date : 2024-03-15 Yixia Chai, Bitao Lin, Jun Zhong, Xiaosheng Wu, Xin Lin, Xiaoyue Ge, Jiayi Jiang, Zhenye Liang, Side Liu, Chuncai Gu
Endoscopic therapy (ET) of gastrointestinal stromal tumors (GIST) has become a viable treatment. We intended to compare long-term outcomes of ET versus surgical resection for 2–5 cm GIST using the Surveillance, Epidemiology, and End Results (SEER) database. A multicenter retrospective study was conducted to compare the long-term outcomes of patients treated with ET and surgical resection for GIST.
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Initial local resection versus early referral for spermatic cord sarcoma: Any impact on treatment timelines and oncological outcomes? Eur. J. Surg. Oncol. (IF 3.8) Pub Date : 2024-03-13 Misbah Khan, Marco Baia, Marco Fiore, Chiara Colombo, Dario Callegaro, Sandro Pasquali, Alessandro Gronchi, Stefano Radaelli
Spermatic cord sarcomas are exceedingly rare, often misdiagnosed and subsequently improperly treated at local hospitals. This retrospective study looked at the oncological outcomes of spermatic cord sarcoma cases managed with curative intent resection at a tertiary referral sarcoma centre. We specifically studied how initial inadequate resections impact the oncologic outcomes compared to primary tumour
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Staging laparoscopy with peritoneal lavage to identify peritoneal metastases and free intraperitoneal cancer cells in the management of locally advanced gastric cancer Eur. J. Surg. Oncol. (IF 3.8) Pub Date : 2024-03-13 B. Huang, V. Rampulla, M. Ri, M. Lindblad, M. Nilsson, I. Rouvelas, F. Klevebro
Gastric cancer often presents in advanced stage with a significant risk for peritoneal dissemination. Staging laparoscopy can be used to detect peritoneal carcinomatosis (PC+) and free cancer cells in peritoneal lavage cytology (CY+). The current study aimed to present the outcomes of staging laparoscopy and the prognosis of PC+ and CY+ in a Swedish high-volume center. A cohort study including all