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Overcoming limitations in current measures of drug response may enable AI-driven precision oncology npj Precis. Oncol. (IF 7.9) Pub Date : 2024-04-24 Katja Ovchinnikova, Jannis Born, Panagiotis Chouvardas, Marianna Rapsomaniki, Marianna Kruithof-de Julio
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A new TROP2-targeting antibody-drug conjugate shows potent antitumor efficacy in breast and lung cancers npj Precis. Oncol. (IF 7.9) Pub Date : 2024-04-23 Dan-dan Zhou, Xiao-tian Zhai, Lan-wen Zhang, Zi-hui Xie, Ying Wang, Yong-su Zhen, Rui-juan Gao, Qing-fang Miao
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Inflammatory pathways confer resistance to chemoradiotherapy in anal squamous cell carcinoma npj Precis. Oncol. (IF 7.9) Pub Date : 2024-04-23 D. Martin, F. Rödel, S. Hehlgans, M. Looso, P. K. Ziegler, M. Fleischmann, M. Diefenhardt, L. Fries, G. Kalinauskaite, I. Tinhofer, D. Zips, C. Gani, C. Rödel, E. Fokas
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Evaluating cell culture reliability in pediatric brain tumor primary cells through DNA methylation profiling npj Precis. Oncol. (IF 7.9) Pub Date : 2024-04-18 Lucia Pedace, Simone Pizzi, Luana Abballe, Maria Vinci, Celeste Antonacci, Sara Patrizi, Claudia Nardini, Francesca Del Bufalo, Sabrina Rossi, Giulia Pericoli, Francesca Gianno, Zein Mersini Besharat, Luca Tiberi, Angela Mastronuzzi, Elisabetta Ferretti, Marco Tartaglia, Franco Locatelli, Andrea Ciolfi, Evelina Miele
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A multi-cancer early detection blood test using machine learning detects early-stage cancers lacking USPSTF-recommended screening npj Precis. Oncol. (IF 7.9) Pub Date : 2024-04-17 Janet Vittone, David Gill, Alex Goldsmith, Eric A. Klein, Jordan J. Karlitz
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BRAFV600E-mutant metastatic NSCLC: disease overview and treatment landscape npj Precis. Oncol. (IF 7.9) Pub Date : 2024-04-16 David Planchard, Rachel E. Sanborn, Marcelo V. Negrao, Aria Vaishnavi, Egbert F. Smit
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Image-based consensus molecular subtyping in rectal cancer biopsies and response to neoadjuvant chemoradiotherapy npj Precis. Oncol. (IF 7.9) Pub Date : 2024-04-09 Maxime W. Lafarge, Enric Domingo, Korsuk Sirinukunwattana, Ruby Wood, Leslie Samuel, Graeme Murray, Susan D. Richman, Andrew Blake, David Sebag-Montefiore, Simon Gollins, Eckhard Klieser, Daniel Neureiter, Florian Huemer, Richard Greil, Philip Dunne, Philip Quirke, Lukas Weiss, Jens Rittscher, Tim Maughan, Viktor H. Koelzer
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Development and validation of a deep learning-based microsatellite instability predictor from prostate cancer whole-slide images npj Precis. Oncol. (IF 7.9) Pub Date : 2024-04-09 Qiyuan Hu, Abbas A. Rizvi, Geoffery Schau, Kshitij Ingale, Yoni Muller, Rachel Baits, Sebastian Pretzer, Aïcha BenTaieb, Abigail Gordhamer, Roberto Nussenzveig, Adam Cole, Matthew O. Leavitt, Ryan D. Jones, Rohan P. Joshi, Nike Beaubier, Martin C. Stumpe, Kunal Nagpal
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Mutational signature-based identification of DNA repair deficient gastroesophageal adenocarcinomas for therapeutic targeting npj Precis. Oncol. (IF 7.9) Pub Date : 2024-04-08 Aurel Prosz, Pranshu Sahgal, Brandon M. Huffman, Zsofia Sztupinszki, Clare X. Morris, David Chen, Judit Börcsök, Miklos Diossy, Viktoria Tisza, Sandor Spisak, Pornlada Likasitwatanakul, Orsolya Rusz, Istvan Csabai, Michael Cecchini, Yasmine Baca, Andrew Elliot, Peter Enzinger, Harshabad Singh, Jessalyn Ubellaker, Jean-Bernard Lazaro, James M. Cleary, Zoltan Szallasi, Nilay S. Sethi
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Comparative molecular profiling of pancreatic ductal adenocarcinoma of the head versus body and tail npj Precis. Oncol. (IF 7.9) Pub Date : 2024-04-06 Maen Abdelrahim, Abdullah Esmail, Anup Kasi, Nestor F. Esnaola, Joanne Xiu, Yasmine Baca, Benjamin A. Weinberg
Pancreatic ductal adenocarcinoma (PDAC) of the head (H) and body/tail (B/T) differ in embryonic origin, cell composition, blood supply, lymphatic and venous drainage, and innervation. We aimed to compare the molecular and tumor immune microenvironment (TIME) profiles of PDAC of the H vs. B/T. A total of 3499 PDAC samples were analyzed via next-generation sequencing (NGS) of RNA (whole transcriptome
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Enhanced plant-derived vesicles for nucleotide delivery for cancer therapy npj Precis. Oncol. (IF 7.9) Pub Date : 2024-04-06 Sara Corvigno, Yuan Liu, Emine Bayraktar, Elaine Stur, Nazende Nur Bayram, Adrian Lankenau Ahumada, Supriya Nagaraju, Cristian Rodriguez-Aguayo, Hu Chen, Thanh Chung Vu, Yunfei Wen, Han Liang, Li Zhao, Sanghoon Lee, Gabriel Lopez-Berestein, Anil K. Sood
Small RNAs (microRNAs [miRNAs] or small interfering RNAs [siRNAs]) are effective tools for cancer therapy, but many of the existing carriers for their delivery are limited by low bioavailability, insufficient loading, impaired transport across biological barriers, and low delivery into the tumor microenvironment. Extracellular vesicle (EV)–based communication in mammalian and plant systems is important
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Scientific figures interpreted by ChatGPT: strengths in plot recognition and limits in color perception npj Precis. Oncol. (IF 7.9) Pub Date : 2024-04-05 Jinge Wang, Qing Ye, Li Liu, Nancy Lan Guo, Gangqing Hu
Emerging studies underscore the promising capabilities of large language model-based chatbots in conducting basic bioinformatics data analyses. The recent feature of accepting image inputs by ChatGPT, also known as GPT-4V(ision), motivated us to explore its efficacy in deciphering bioinformatics scientific figures. Our evaluation with examples in cancer research, including sequencing data analysis
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Post-therapy emergence of an NBN reversion mutation in a patient with pancreatic acinar cell carcinoma npj Precis. Oncol. (IF 7.9) Pub Date : 2024-04-01 Meredith S. Pelster, Ian M. Silverman, Joseph D. Schonhoft, Adrienne Johnson, Pier Selenica, Danielle Ulanet, Victoria Rimkunas, Jorge S. Reis-Filho
Pancreatic acinar cell carcinoma (PACC) is a rare form of pancreatic cancer that commonly harbors targetable alterations, including activating fusions in the MAPK pathway and loss-of-function (LOF) alterations in DNA damage response/homologous recombination DNA repair-related genes. Here, we describe a patient with PACC harboring both somatic biallelic LOF of NBN and an activating NTRK1 fusion. Upon
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ELAVL2 loss promotes aggressive mesenchymal transition in glioblastoma npj Precis. Oncol. (IF 7.9) Pub Date : 2024-03-28 Yona Kim, Ji Hyeon You, Yeonjoo Ryu, Gyuri Park, Urim Lee, Hyo Eun Moon, Hye Ran Park, Chang W. Song, Ja-Lok Ku, Sung-Hye Park, Sun Ha Paek
Glioblastoma (GBM), the most lethal primary brain cancer, exhibits intratumoral heterogeneity and molecular plasticity, posing challenges for effective treatment. Despite this, the regulatory mechanisms underlying such plasticity, particularly mesenchymal (MES) transition, remain poorly understood. In this study, we elucidate the role of the RNA-binding protein ELAVL2 in regulating aggressive MES transformation
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Tumor heterogeneity and clinically invisible micrometastases in metastatic breast cancer—a call for enhanced surveillance strategies npj Precis. Oncol. (IF 7.9) Pub Date : 2024-03-29 Eliza R. Bacon, Kena Ihle, Weihua Guo, Colt A. Egelston, Diana L. Simons, Christina Wei, Lusine Tumyan, Daniel Schmolze, Peter P. Lee, James R. Waisman
The biology of metastatic breast cancer (MBC) is understudied, primarily due to the difficulty of procuring multiple samples from patients with oligometastatic breast cancer. We developed a rapid postmortem tissue procurement program that allows the collection and analysis of numerous metastatic lesions, subclinical locations, and potential pre-metastatic niches that fall within this scope. We conducted
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Artificial intelligence in neuro-oncology: advances and challenges in brain tumor diagnosis, prognosis, and precision treatment npj Precis. Oncol. (IF 7.9) Pub Date : 2024-03-29 Sirvan Khalighi, Kartik Reddy, Abhishek Midya, Krunal Balvantbhai Pandav, Anant Madabhushi, Malak Abedalthagafi
This review delves into the most recent advancements in applying artificial intelligence (AI) within neuro-oncology, specifically emphasizing work on gliomas, a class of brain tumors that represent a significant global health issue. AI has brought transformative innovations to brain tumor management, utilizing imaging, histopathological, and genomic tools for efficient detection, categorization, outcome
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A multiparameter liquid biopsy approach allows to track melanoma dynamics and identify early treatment resistance npj Precis. Oncol. (IF 7.9) Pub Date : 2024-03-28 Maria Chiara Scaini, Cristina Catoni, Cristina Poggiana, Jacopo Pigozzo, Luisa Piccin, Kevin Leone, Ilaria Scarabello, Antonella Facchinetti, Chiara Menin, Lisa Elefanti, Stefania Pellegrini, Valentina Aleotti, Riccardo Vidotto, Francesca Schiavi, Alessio Fabozzi, Vanna Chiarion-Sileni, Antonio Rosato
Melanoma heterogeneity is a hurdle in metastatic disease management. Although the advent of targeted therapy has significantly improved patient outcomes, the occurrence of resistance makes monitoring of the tumor genetic landscape mandatory. Liquid biopsy could represent an important biomarker for the real-time tracing of disease evolution. Thus, we aimed to correlate liquid biopsy dynamics with treatment
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Pan-cancer evaluation of regulated cell death to predict overall survival and immune checkpoint inhibitor response npj Precis. Oncol. (IF 7.9) Pub Date : 2024-03-27 Wei Zhang, Yongwei Zhu, Hongyi Liu, Yihao Zhang, Hongwei Liu, Abraham Ayodeji Adegboro, Ruiyue Dang, Luohuan Dai, Siyi Wanggou, Xuejun Li
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Artificial intelligence-based assessment of PD-L1 expression in diffuse large B cell lymphoma npj Precis. Oncol. (IF 7.9) Pub Date : 2024-03-27 Fang Yan, Qian Da, Hongmei Yi, Shijie Deng, Lifeng Zhu, Mu Zhou, Yingting Liu, Ming Feng, Jing Wang, Xuan Wang, Yuxiu Zhang, Wenjing Zhang, Xiaofan Zhang, Jingsheng Lin, Shaoting Zhang, Chaofu Wang
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Single-cell and spatial analyses revealed the co-location of cancer stem cells and SPP1+ macrophage in hypoxic region that determines the poor prognosis in hepatocellular carcinoma npj Precis. Oncol. (IF 7.9) Pub Date : 2024-03-23 Guangyu Fan, Tongji Xie, Lin Li, Le Tang, Xiaohong Han, Yuankai Shi
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Identification of potentially actionable genetic variants in epithelial ovarian cancer: a retrospective cohort study npj Precis. Oncol. (IF 7.9) Pub Date : 2024-03-22 Charlotte Fieuws, Joni Van der Meulen, Kristiaan Proesmans, Emiel A. De Jaeghere, Siebe Loontiens, Jo Van Dorpe, Philippe Tummers, Hannelore Denys, Koen Van de Vijver, Kathleen B. M. Claes
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Targeting TYK2 alleviates Rab27A-induced malignant progression of non-small cell lung cancer via disrupting IFNα-TYK2-STAT-HSPA5 axis npj Precis. Oncol. (IF 7.9) Pub Date : 2024-03-23 Yuanyuan Zeng, Jian Zhao, Zhengyan Wu, Yongkang Huang, Anqi Wang, Jianjie Zhu, Mengmeng Xu, Weijie Zhang, Xiaohui Zhang, Jianjun Li, Jian-an Huang, Zeyi Liu
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Large language models and multimodal foundation models for precision oncology npj Precis. Oncol. (IF 7.9) Pub Date : 2024-03-22 Daniel Truhn, Jan-Niklas Eckardt, Dyke Ferber, Jakob Nikolas Kather
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Deep learning on tertiary lymphoid structures in hematoxylin-eosin predicts cancer prognosis and immunotherapy response npj Precis. Oncol. (IF 7.9) Pub Date : 2024-03-22 Ziqiang Chen, Xiaobing Wang, Zelin Jin, Bosen Li, Dongxian Jiang, Yanqiu Wang, Mengping Jiang, Dandan Zhang, Pei Yuan, Yahui Zhao, Feiyue Feng, Yicheng Lin, Liping Jiang, Chenxi Wang, Weida Meng, Wenjing Ye, Jie Wang, Wenqing Qiu, Houbao Liu, Dan Huang, Yingyong Hou, Xuefei Wang, Yuchen Jiao, Jianming Ying, Zhihua Liu, Yun Liu
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ERK pathway agonism for cancer therapy: evidence, insights, and a target discovery framework npj Precis. Oncol. (IF 7.9) Pub Date : 2024-03-14 Oleg Timofeev, Philippe Giron, Steffen Lawo, Martin Pichler, Maxim Noeparast
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Proteogenomic analysis of enriched HGSOC tumor epithelium identifies prognostic signatures and therapeutic vulnerabilities npj Precis. Oncol. (IF 7.9) Pub Date : 2024-03-13 Nicholas W. Bateman, Tamara Abulez, Anthony R. Soltis, Andrew McPherson, Seongmin Choi, Dale W. Garsed, Ahwan Pandey, Chunqiao Tian, Brian L. Hood, Kelly A. Conrads, Pang-ning Teng, Julie Oliver, Glenn Gist, Dave Mitchell, Tracy J. Litzi, Christopher M. Tarney, Barbara A. Crothers, Paulette Mhawech-Fauceglia, Clifton L. Dalgard, Matthew D. Wilkerson, Mariaelena Pierobon, Emanuel F. Petricoin, Chunhua
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Genome-matched treatments and patient outcomes in the Maine Cancer Genomics Initiative (MCGI) npj Precis. Oncol. (IF 7.9) Pub Date : 2024-03-09 Eric C. Anderson, John DiPalazzo, F. Lee Lucas, Michael J. Hall, Andrey Antov, Petra Helbig, Jennifer Bourne, Leah Graham, Lory Gaitor, Christine Lu-Emerson, Leslie S. Bradford, Roger Inhorn, Sarah J. Sinclair, Philip L. Brooks, Christian A. Thomas, Karen Rasmussen, Paul K. J. Han, Edison T. Liu, Jens Rueter
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Decoding gene regulatory circuitry underlying TNBC chemoresistance reveals biomarkers for therapy response and therapeutic targets npj Precis. Oncol. (IF 7.9) Pub Date : 2024-03-12 Ryan Lusby, Ziyi Zhang, Arun Mahesh, Vijay K. Tiwari
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Biallelic EPCAM deletions induce tissue-specific DNA repair deficiency and cancer predisposition npj Precis. Oncol. (IF 7.9) Pub Date : 2024-03-11 V. J. Forster, M. Aronson, C. Zhang, J. Chung, S. Sudhaman, M. A. Galati, J. Kelly, L. Negm, A. B. Ercan, L. Stengs, C. Durno, M. Edwards, M. Komosa, L. E. Oldfield, N. M. Nunes, S. Pedersen, J. Wellum, I. Siddiqui, V. Bianchi, B. R. Weil, V. L. Fox, T. J. Pugh, J. Kamihara, U. Tabori
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Connectivity mapping-based identification of pharmacological inhibitor targeting HDAC6 in aggressive pancreatic ductal adenocarcinoma npj Precis. Oncol. (IF 7.9) Pub Date : 2024-03-07 Pranita Atri, Ashu Shah, Gopalakrishnan Natarajan, Satyanarayana Rachagani, Sanchita Rauth, Koelina Ganguly, Joseph Carmicheal, Dario Ghersi, Jesse L. Cox, Lynette M. Smith, Maneesh Jain, Sushil Kumar, Moorthy P. Ponnusamy, Parthasarathy Seshacharyulu, Surinder K. Batra
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Remodeling the tumor-immune microenvironment by anti-CTLA4 blockade enhanced subsequent anti-PD-1 efficacy in advanced nasopharyngeal carcinoma npj Precis. Oncol. (IF 7.9) Pub Date : 2024-03-06 Yuxiang Ma, Huaqiang Zhou, Fan Luo, Yang Zhang, Changbin Zhu, Weiwei Li, Zhan Huang, Jingbo Zhao, Jinhui Xue, Yuanyuan Zhao, Wenfeng Fang, Yunpeng Yang, Yan Huang, Li Zhang, Hongyun Zhao
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Adaptive Darwinian off-target resistance mechanisms to selective RET inhibition in RET driven cancer npj Precis. Oncol. (IF 7.9) Pub Date : 2024-03-04 Vivek Subbiah, Mohamed A. Gouda, J. Bryan Iorgulescu, Ramona Dadu, Keyur Patel, Steven Sherman, Maria Cabanillas, Mimi Hu, Luz E. Castellanos, Behrang Amini, Funda Meric-Bernstam, Tao Shen, Jie Wu
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New pan-ALK inhibitor-resistant EML4::ALK mutations detected by liquid biopsy in lung cancer patients npj Precis. Oncol. (IF 7.9) Pub Date : 2024-03-06 Matteo Villa, Federica Malighetti, Elisa Sala, Geeta G. Sharma, Giulia Arosio, Maria Gemelli, Chiara Manfroni, Diletta Fontana, Nicoletta Cordani, Raffaella Meneveri, Alfonso Zambon, Rocco Piazza, Fabio Pagni, Diego Cortinovis, Luca Mologni
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An interpretable machine learning system for colorectal cancer diagnosis from pathology slides npj Precis. Oncol. (IF 7.9) Pub Date : 2024-03-05 Pedro C. Neto, Diana Montezuma, Sara P. Oliveira, Domingos Oliveira, João Fraga, Ana Monteiro, João Monteiro, Liliana Ribeiro, Sofia Gonçalves, Stefan Reinhard, Inti Zlobec, Isabel M. Pinto, Jaime S. Cardoso
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Recurrent UBE3C-LRP5 translocations in head and neck cancer with therapeutic implications npj Precis. Oncol. (IF 7.9) Pub Date : 2024-03-04 Bhasker Dharavath, Ashwin Butle, Akshita Chaudhary, Ankita Pal, Sanket Desai, Aniket Chowdhury, Rahul Thorat, Pawan Upadhyay, Sudhir Nair, Amit Dutt
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TP53 gain-of-function mutations promote osimertinib resistance via TNF-α–NF-κB signaling in EGFR-mutated lung cancer npj Precis. Oncol. (IF 7.9) Pub Date : 2024-03-02 Ritsu Ibusuki, Eiji Iwama, Atsushi Shimauchi, Hirono Tsutsumi, Yasuto Yoneshima, Kentaro Tanaka, Isamu Okamoto
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Tertiary lymphoid structures predict survival and response to neoadjuvant therapy in locally advanced rectal cancer npj Precis. Oncol. (IF 7.9) Pub Date : 2024-03-02 Qianyu Wang, Wentao Zhong, Xiaofei Shen, Zechen Hao, Meng Wan, Xiaopeng Yang, Ran An, Hongyan Zhu, Huiyun Cai, Tao Li, Yuan Lv, Xing Dong, Gang Chen, Aijun Liu, Junfeng Du
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Patient derived tumoroids of high grade neuroendocrine neoplasms for more personalized therapies npj Precis. Oncol. (IF 7.9) Pub Date : 2024-03-01 Simon L. April-Monn, Philipp Kirchner, Katharina Detjen, Konstantin Bräutigam, Mafalda A. Trippel, Tobias Grob, Cyril Statzer, Renaud S. Maire, Attila Kollàr, Aziz Chouchane, Catarina A. Kunze, David Horst, Martin C. Sadowski, Jörg Schrader, Ilaria Marinoni, Bertram Wiedenmann, Aurel Perren
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Germline determinants of aberrant signaling pathways in cancer npj Precis. Oncol. (IF 7.9) Pub Date : 2024-03-01 Davide Dalfovo, Riccardo Scandino, Marta Paoli, Samuel Valentini, Alessandro Romanel
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SOCS5-RBMX stimulates SREBP1-mediated lipogenesis to promote metastasis in steatotic HCC with HBV-related cirrhosis npj Precis. Oncol. (IF 7.9) Pub Date : 2024-03-01 Youpeng Wang, Ziyin Zhao, Tingting Guo, Tiansong Wu, Mao Zhang, Dingan Luo, Kunpeng Dou, Yeni Yang, Cheng Jin, Bingyuan Zhang, Bin Zhang, Bing Han
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Immune microenvironment heterogeneity of concurrent adenocarcinoma and squamous cell carcinoma in multiple primary lung cancers npj Precis. Oncol. (IF 7.9) Pub Date : 2024-02-29 Jiahao Zhang, Yiheng Huang, Yichao Han, Dong Dong, Yuqin Cao, Xiang Chen, Di Liu, Xueyan Cheng, Debin Sun, Hecheng Li, Yajie Zhang
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Zebrafish tumour xenograft models: a prognostic approach to epithelial ovarian cancer npj Precis. Oncol. (IF 7.9) Pub Date : 2024-02-27 Gabriel Lindahl, Sebastian Fjellander, Karthik Selvaraj, Malin Vildeval, Zaheer Ali, Rusul Almter, Anna Erkstam, Gabriela Vazquez Rodriguez, Annelie Abrahamsson, Åsa Rydmark Kersley, Anna Fahlgren, Preben Kjølhede, Stig Linder, Charlotta Dabrosin, Lasse Jensen
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Multimodal fusion of liquid biopsy and CT enhances differential diagnosis of early-stage lung adenocarcinoma npj Precis. Oncol. (IF 7.9) Pub Date : 2024-02-26 Yanwei Zhang, Beibei Sun, Yinghong Yu, Jun Lu, Yuqing Lou, Fangfei Qian, Tianxiang Chen, Li Zhang, Jiancheng Yang, Hua Zhong, Ligang Wu, Baohui Han
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A functional personalised oncology approach against metastatic colorectal cancer in matched patient derived organoids npj Precis. Oncol. (IF 7.9) Pub Date : 2024-02-27 Dexter Kai Hao Thng, Lissa Hooi, Bei En Siew, Kai-Yin Lee, Ian Jse-Wei Tan, Bettina Lieske, Norman Sihan Lin, Alfred Wei Chieh Kow, Shi Wang, Masturah Bte Mohd Abdul Rashid, Chermaine Ang, Jasmin Jia Min Koh, Tan Boon Toh, Ker-Kan Tan, Edward Kai-Hua Chow
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Genomic landscape of liquid biopsy mutations in TP53 and DNA damage genes in cancer patients npj Precis. Oncol. (IF 7.9) Pub Date : 2024-02-26 Damien Vasseur, Ahmadreza Arbab, Fabiola Giudici, Christophe Marzac, Stefan Michiels, Marco Tagliamento, Arnaud Bayle, Cristina Smolenschi, Madona Sakkal, Mihaela Aldea, Hela Sassi, Filippo Gustavo Dall’Olio, Noémie Pata-Merci, Sophie Cotteret, Alice Fiévet, Nathalie Auger, Luc Friboulet, Francesco Facchinetti, Arthur Géraud, Santiago Ponce, Antoine Hollebecque, Benjamin Besse, Jean Baptiste Micol
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Machine learning reveals diverse cell death patterns in lung adenocarcinoma prognosis and therapy npj Precis. Oncol. (IF 7.9) Pub Date : 2024-02-26 Shun Wang, Ruohuang Wang, Dingtao Hu, Caoxu Zhang, Peng Cao, Jie Huang
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Clonal gene signatures predict prognosis in mesothelioma and lung adenocarcinoma npj Precis. Oncol. (IF 7.9) Pub Date : 2024-02-23 Yupei Lin, Bryan M. Burt, Hyun-Sung Lee, Thinh T. Nguyen, Hee-Jin Jang, Claire Lee, Wei Hong, Robert Taylor Ripley, Christopher I. Amos, Chao Cheng
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Stroma-specific gene expression signature identifies prostate cancer subtype with high recurrence risk npj Precis. Oncol. (IF 7.9) Pub Date : 2024-02-23 Martin Rasmussen, Jacob Fredsøe, Paul Vinu Salachan, Marcus Pii Lunau Blanke, Stine Hesselby Larsen, Benedicte Parm Ulhøi, Jørgen Bjerggaard Jensen, Michael Borre, Karina Dalsgaard Sørensen
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UroPredict: Machine learning model on real-world data for prediction of kidney cancer recurrence (UroCCR-120) npj Precis. Oncol. (IF 7.9) Pub Date : 2024-02-23 Gaëlle Margue, Loïc Ferrer, Guillaume Etchepare, Pierre Bigot, Karim Bensalah, Arnaud Mejean, Morgan Roupret, Nicolas Doumerc, Alexandre Ingels, Romain Boissier, Géraldine Pignot, Bastien Parier, Philippe Paparel, Thibaut Waeckel, Thierry Colin, Jean-Christophe Bernhard
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A macrocyclic kinase inhibitor overcomes triple resistant mutations in EGFR-positive lung cancer npj Precis. Oncol. (IF 7.9) Pub Date : 2024-02-23 Mai Suzuki, Ken Uchibori, Tomoko Oh-hara, Yumi Nomura, Ryusei Suzuki, Ai Takemoto, Mitsugu Araki, Shigeyuki Matsumoto, Yukari Sagae, Mutsuko Kukimoto-Niino, Yusuke Kawase, Mikako Shirouzu, Yasushi Okuno, Makoto Nishio, Naoya Fujita, Ryohei Katayama
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Liquid biopsy guides successful molecular targeted therapy of an inoperable pediatric brainstem neoplasm npj Precis. Oncol. (IF 7.9) Pub Date : 2024-02-22 Cecilia Arthur, Lena-Maria Carlson, Jan Svoboda, Ulrika Sandvik, Cecilia Jylhä, Magnus Nordenskjöld, Stefan Holm, Emma Tham
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Sequencing of cerebrospinal fluid cell-free DNA facilitated early differential diagnosis of intramedullary spinal cord tumors npj Precis. Oncol. (IF 7.9) Pub Date : 2024-02-22 Ruichao Chai, Songyuan An, Han Lin, Bo Pang, Hao Yan, Yun Liu, Yilin Wu, Long Wang, Xing Liu, Huiyuan Chen, Xueyu Yang, Qing Chang, Wenqing Jia, Yongzhi Wang
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A whirl of radiomics-based biomarkers in cancer immunotherapy, why is large scale validation still lacking? npj Precis. Oncol. (IF 7.9) Pub Date : 2024-02-21 Marta Ligero, Bente Gielen, Victor Navarro, Pablo Cresta Morgado, Olivia Prior, Rodrigo Dienstmann, Paolo Nuciforo, Stefano Trebeschi, Regina Beets-Tan, Evis Sala, Elena Garralda, Raquel Perez-Lopez
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Selpercatinib combination with the mitochondria-targeted antioxidant MitoQ effectively suppresses RET–mutant thyroid cancer npj Precis. Oncol. (IF 7.9) Pub Date : 2024-02-20 Wenjing Chen, Sophie Dream, Pui-Yin Leung, Pui-Kei Wu, Stuart Wong, Jong-In Park
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Machine learning and radiomics for segmentation and classification of adnexal masses on ultrasound npj Precis. Oncol. (IF 7.9) Pub Date : 2024-02-20 Jennifer F. Barcroft, Kristofer Linton-Reid, Chiara Landolfo, Maya Al-Memar, Nina Parker, Chris Kyriacou, Maria Munaretto, Martina Fantauzzi, Nina Cooper, Joseph Yazbek, Nishat Bharwani, Sa Ra Lee, Ju Hee Kim, Dirk Timmerman, Joram Posma, Luca Savelli, Srdjan Saso, Eric O. Aboagye, Tom Bourne
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Molecular mechanisms of tumour development in glioblastoma: an emerging role for the circadian clock npj Precis. Oncol. (IF 7.9) Pub Date : 2024-02-20 Nina Nelson, Angela Relógio
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Delineating functional and molecular impact of ex vivo sample handling in precision medicine npj Precis. Oncol. (IF 7.9) Pub Date : 2024-02-19 Nona Struyf, Albin Österroos, Mattias Vesterlund, Cornelia Arnroth, Tojo James, Stephanie Sunandar, Georgios Mermelekas, Anna Bohlin, Kerstin Hamberg Levedahl, Sofia Bengtzén, Rozbeh Jafari, Lukas M. Orre, Janne Lehtiö, Sören Lehmann, Päivi Östling, Olli Kallioniemi, Brinton Seashore-Ludlow, Tom Erkers
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INHBA(+) cancer-associated fibroblasts generate an immunosuppressive tumor microenvironment in ovarian cancer npj Precis. Oncol. (IF 7.9) Pub Date : 2024-02-15 Ye Hu, Maria Sol Recouvreux, Marcela Haro, Enes Taylan, Barbie Taylor-Harding, Ann E. Walts, Beth Y. Karlan, Sandra Orsulic
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EORTC-SPECTA Arcagen study, comprehensive genomic profiling and treatment adaptation of rare thoracic cancers npj Precis. Oncol. (IF 7.9) Pub Date : 2024-02-16 Marco Tagliamento, Marie Morfouace, Charalambos Loizides, Julio Oliveira, Laurent Greillier, Judith Raimbourg, Anne-Claire Toffart, Thierry Chatellier, Nicolas Cloarec, Ivana Sullivan, Birute Brasiuniene, Michael Duruisseaux, Kersti Oselin, Marie-Sophie Robert, Carolina Fernandes, Arnaud Poncin, Jean-Yves Blay, Benjamin Besse, Nicolas Girard
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Cancer-related cells and oncosomes in the liquid biopsy of pancreatic cancer patients undergoing surgery npj Precis. Oncol. (IF 7.9) Pub Date : 2024-02-15 Stephanie N. Shishido, Emmeline Lin, Nicholas Nissen, George Courcoubetis, Divya Suresh, Jeremy Mason, Arsen Osipov, Andrew E. Hendifar, Michael Lewis, Srinivas Gaddam, Stephen Pandol, Peter Kuhn, Simon K. Lo