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Endocrine disrupting chemicals: gestational diabetes and beyond Diabetol. Metab. Syndr. (IF 4.8) Pub Date : 2024-04-26 Tridip Mitra, Richa Gulati, Krithika Ramachandran, Rohan Rajiv, Elizabeth Ann L. Enninga, Chris K Pierret, Sajeetha Kumari R, Rajiv Janardhanan
Gestational Diabetes Mellitus (GDM) has been on the rise for the last two decades along with the growing incidence of obesity. The ubiquitous use of Endocrine-Disrupting Chemicals (EDCs) worldwide has been associated with this increase in GDM incidence. Epigenetic modifications such as DNA methylation, histone acetylation, and methylation have been associated with prenatal exposure to EDCs. EDC exposure
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Effect of the SARS-CoV-2 pandemic on metabolic control in patients with type 2 diabetes: a 5-year cohort follow-up managed by a dynamic multidisciplinary team in Northeastern Mexico Diabetol. Metab. Syndr. (IF 4.8) Pub Date : 2024-04-25 Devany Paola Morales-Rodriguez, Arnulfo González-Cantú, Arnulfo Garza-Silva, Andrea Rivera-Cavazos, Iván Francisco Fernández-Chau, Andrea Belinda Cepeda-Medina, Miguel Angel Sanz-Sánchez, Gerardo Francisco del Rio-Parra, María Angelina Torres-Fuentes, Miguel Assael Rodriguez-Puente, Maria Elena Romero-Ibarguengoitia
The SARS-CoV-2 pandemic brought a radical shift in the healthcare system and suboptimal care for vulnerable patients, such as those with Type 2 Diabetes Mellitus (T2D). Therefore, we compared metabolic control and macro/microvascular complications of patients with T2D before and throughout the three-year SARS-CoV-2 pandemic. A retrospective observational cohort of subjects with T2D studied from 2018
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The effects of bupropion alone and combined with naltrexone on weight loss: a systematic review and meta-regression analysis of randomized controlled trials Diabetol. Metab. Syndr. (IF 4.8) Pub Date : 2024-04-24 Yang Liu, Fei Han, Zefeng Xia, Ping Sun, Pejman Rohani, Palanisamy Amirthalingam, Mohammad Hassan Sohouli
The global prevalence of obesity and overweight is a significant concern in the field of public health. However, addressing and combating these conditions pose considerable challenges. Numerous interventional studies have been conducted to assess the possible impact of bupropion on weight reduction. The primary objective of this study was to conduct a comprehensive investigation into the effects of
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The efficacy and safety of GLP-1 receptor agonists in youth with type 2 diabetes: a meta-analysis Diabetol. Metab. Syndr. (IF 4.8) Pub Date : 2024-04-24 Louise Buonalumi Tacito Yugar, Luis Gustavo Sedenho-Prado, Isadora Maria Castilho da Silva Ferreira, Cleide Aparecida Moreira Silva, Andrei C. Sposito, Cintia Cercato
Glucagon-like peptide 1 receptor agonists have been proven to be effective in adults with diabetes and children with obesity. However, children with type 2 diabetes constitute an underrepresented subpopulation with limited treatment options. This meta-analysis aimed to determine more precise estimates of the efficacy and safety of glucagon-like peptide-1 agonists in pediatric type 2 diabetes mellitus
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Increased serum asprosin is correlated with diabetes mellitus-induced erectile dysfunction Diabetol. Metab. Syndr. (IF 4.8) Pub Date : 2024-04-24 Chun-Hui Li, Xue Zhao, Yi Xu, Fang Zhang, Chun-Ting Li, Si-Nan Zhao, Yong-Mei Hao
Asprosin, a newly identified adipokine, is pathologically increased in type 2 diabetes. The aim of this study is to see whether serum asprosin concentrations are linked to diabetes mellitus-induced erectile dysfunction (DMED). 90 male patients with type 2 diabetes were included. According to the International Index of Erectile Function (IIEF-5) score, they were classified into two groups: 45 type 2
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Mendelian randomisation highlights type 1 diabetes as a causal determinant of idiopathic pulmonary fibrosis Diabetol. Metab. Syndr. (IF 4.8) Pub Date : 2024-04-24 Xinlai Ma, Yang Zhang, Fan Wu, Xue Liu, Wei Zhang
It is unclear whether type 1 diabetes (T1D) causes idiopathic pulmonary fibrosis (IPF), despite observational research linking the two conditions. Therefore, our study aimed to examine the causal link between T1D and the likelihood of IPF by employing the Mendelian randomization (MR) technique of two-sample Mendelian randomization. Using data from two genome-wide association studies (GWAS) with European
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Causal effect of gut microbiota and diabetic nephropathy: a Mendelian randomization study Diabetol. Metab. Syndr. (IF 4.8) Pub Date : 2024-04-24 Ganyuan He, Jiayi Chen, Wenke Hao, Wenxue Hu
The interaction of dysbiosis of gut microbiota (GM) with diabetic nephropathy (DN) drew our attention and a better understanding of GM on DN might provide potential therapeutic approaches. However, the exact causal effect of GM on DN remains unknown. We applied two-sample Mendelian Randomization (MR) analysis, including inverse variance weighted (IVW), MR-Egger methods, etc., to screen the significant
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Trends and regional differences in antidiabetic medication use: a nationwide retrospective observational study Diabetol. Metab. Syndr. (IF 4.8) Pub Date : 2024-04-24 Márta Csatordai, Ria Benkő, Mária Matuz, Zsófia Engi, Dezső Csupor, Csaba Lengyel, Péter Doró
The prevalence of diabetes is increasing, and several new drug groups have been authorized and used successfully in the treatment of diabetes, while older drug groups are still in use. Our aim was to assess the utilization tendencies and regional differences in antidiabetic medication consumption in Hungary between 2015 and 2021 and to identify the possible determinants of regional differences in antidiabetic
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The Regulate your Sitting Time (RESIT) intervention for reducing sitting time in individuals with type 2 diabetes: findings from a randomised-controlled feasibility trial Diabetol. Metab. Syndr. (IF 4.8) Pub Date : 2024-04-24 Marsha L. Brierley, Angel M. Chater, Charlotte L. Edwardson, Ellen M. Castle, Emily R. Hunt, Stuart JH. Biddle, Rupa Sisodia, Daniel P. Bailey
Reducing and breaking up sitting is recommended for optimal management of Type 2 diabetes mellitus (T2DM). Yet, there is limited evidence of interventions targeting these outcomes in individuals with this condition. The primary aim of this study was to assess the feasibility and acceptability of delivering and evaluating a tailored online intervention to reduce and break up sitting in adults with T2DM
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Unraveling the interplay of ferroptosis and immune dysregulation in diabetic kidney disease: a comprehensive molecular analysis Diabetol. Metab. Syndr. (IF 4.8) Pub Date : 2024-04-20 Yuanyuan Jiao, Xinze Liu, Jingxuan Shi, Jiaqi An, Tianyu Yu, Guming Zou, Wenge Li, Li Zhuo
Diabetic kidney disease (DKD) is a primary microvascular complication of diabetes with limited therapeutic effects. Delving into the pathogenic mechanisms of DKD and identifying new therapeutic targets is crucial. Emerging studies reveal the implication of ferroptosis and immune dysregulation in the pathogenesis of DKD, however, the precise relationship between them remains not fully elucidated. Investigating
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Impact of SGLT-2 inhibitors on modifiable cardiovascular risk factors in Romanian patients with type 2 diabetes mellitus Diabetol. Metab. Syndr. (IF 4.8) Pub Date : 2024-04-16 Adriana Gherbon, Mirela Frandes, Darius Dîrpeş, Romulus Timar, Bogdan Timar
Modifiable cardiovascular risk factors are high blood pressure, smoking, diabetes, sedentary lifestyle, obesity, and hypercholesterolemia. To investigate the impact of sodium-glucose 2 co-transporter inhibitors (SGLT-2i) on modifiable cardiovascular risk factors in Romanian patients diagnosed with type 2 diabetes mellitus (T2DM). A retrospective study was conducted on 200 Romanian patients with T2DM
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Enhancing insulin sensitivity in type 2 diabetes mellitus using apelin-loaded small extracellular vesicles from Wharton’s jelly-derived mesenchymal stem cells: a novel therapeutic approach Diabetol. Metab. Syndr. (IF 4.8) Pub Date : 2024-04-16 Jing Cui, Mingkun Wang, Wenhong Zhang, Jiachen Sun, Yan Zhang, Li Zhao, Zhibo Hong, Dongtao Li, Yi Xiong Huang, Ningkun Zhang, Yu Chen
Type 2 diabetes mellitus (T2DM), characterized by β-cell dysfunction and insulin resistance (IR), presents considerable treatment challenges. Apelin is an adipocyte-derived factor that shows promise in improving IR; however, it is limited by poor targeting and a short half-life. In the present study, engineered small extracellular vesicles (sEVs) derived from Wharton’s jelly-derived mesenchymal stem
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Hypoglycemia during hyperosmolar hyperglycemic crises is associated with long-term mortality Diabetol. Metab. Syndr. (IF 4.8) Pub Date : 2024-04-10 Tomás González-Vidal, Carmen Lambert, Ana Victoria García, Elsa Villa-Fernández, Pedro Pujante, Jessica Ares-Blanco, Edelmiro Menéndez Torre, Elías Delgado-Álvarez
Previous research has indicated that hypoglycemia during hospitalization is a predictor of unfavorable outcomes in patients with diabetes. However, no studies have examined the long-term impact of hypoglycemia in adults admitted for hyperglycemic crises. The study was aimed to investigate the long-term implications of hypoglycemia during hyperosmolar hyperglycemic crises, particularly in terms of all-cause
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Association of maternal exposure to endocrine disruptor chemicals with cardio-metabolic risk factors in children during childhood: a systematic review and meta-analysis of cohort studies Diabetol. Metab. Syndr. (IF 4.8) Pub Date : 2024-04-04 Mehran Rahimlou, Mir Ali Mousavi, Hossein Chiti, Mazyar Peyda, Seyedeh Neda Mousavi
In the present systematic review and meta-analysis, the association of maternal exposure to the endocrine disrupting chemicals (EDCs) with cardio-metabolic risk factors in children during childhood for the first time. The PubMed, Scopus, EMBASE, and Web of Science databases were systematically searched, up to Feb 2023. In total 30 cohort studies had our inclusion criteria. A random-effects model was
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The synergistic effect of obesity and dyslipidemia on hypertension: results from the STEPS survey Diabetol. Metab. Syndr. (IF 4.8) Pub Date : 2024-04-03 Parisa Mohseni, Davood Khalili, Shirin Djalalinia, Hamideh Mohseni, Farshad Farzadfar, Arman Shafiee, Neda Izadi
Obesity and dyslipidemia are important risk factors for hypertension (HTN). When these two conditions coexist, they may interact in a synergistic manner and increase the risk of developing HTN and its associated complications. The aim of this study was to investigate the synergistic effect of general and central obesity with dyslipidemia on the risk of HTN. Data from 40,387 individuals aged 25 to 64
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Efficacy and safety of once-weekly insulin icodec compared to once-daily insulin g U-100 in patients with type II diabetes: a systematic review and meta-analysis Diabetol. Metab. Syndr. (IF 4.8) Pub Date : 2024-04-03 Syed Zia Saleem, Areeba Fareed, Syed Muhammad Muneeb Akhtar, Solay Farhat, Amira Mohamed Taha, Aymar Akilimali
Diabetes affects millions of people globally, despite treatment options, adherence and other factors pose obstacles. Once-weekly Insulin Icodec, a novel basal Insulin analog with a week-long half-life, offers potential benefits, enhancing convenience, adherence, and quality of life for improved glycemic control. This systematic review and meta-analysis aimed to assess the efficacy and safety of once-weekly
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Association between stress hyperglycemia ratio and diabetes mellitus mortality in American adults: a retrospective cohort study and predictive model establishment based on machine learning algorithms (NHANES 2009–2018) Diabetol. Metab. Syndr. (IF 4.8) Pub Date : 2024-04-02 Fengjuan Yan, Limin Zhao, Xiaoqing Quan, Jialiang Zhu
Stress hyperglycemia is a physiological response of the body under stress to make adaptive adjustments in response to changes in the internal environment. The stress hyperglycemia ratio (SHR) is a new indicator after adjusting the basal blood glucose level of the population. Previous studies have shown that SHR is associated with poor prognosis in many diseases, such as cardiovascular and cerebrovascular
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A comparison of various insulin resistance indices and the possibility of hypertension in military adults: CHIEF study Diabetol. Metab. Syndr. (IF 4.8) Pub Date : 2024-04-02 Wei-Che Huang, Kun-Zhe Tsai, Kai-Ti Yang, Han-Hsing Chen, Younghoon Kwon, Gen-Min Lin
Insulin resistance is associated with the development of hypertension, whereas there were rare studies comparing various non-insulin based insulin resistance (NI-IR) indices for the possibility of hypertension among young and middle-aged adults. This cross-sectional study included a total of 4,080 military personnel, aged 18–50 years, without antihypertensive medications therapy in 2014. All subjects
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Causal effects of glycemic traits and endometriosis: a bidirectional and multivariate mendelian randomization study Diabetol. Metab. Syndr. (IF 4.8) Pub Date : 2024-03-27 Qing Xin, Hao-Jia Li, Hao-Kai Chen, Xiao-Feng Zhu, Lin Yu
Observational studies have suggested an association between endometriosis and glycemic traits, but causality remains unclear. We used bidirectional and multivariate Mendelian randomization (MR) to examine the causal effect of glycemic traits on endometriosis and vice versa. We obtained genome-wide association studies summary data of endometriosis and glycemic traits in our study. Inverse variance weighted
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Correction: Neutrophil killing of Staphylococcus aureus in diabetes, obesity and metabolic syndrome: a prospective cellular surveillance study Diabetol. Metab. Syndr. (IF 4.8) Pub Date : 2024-03-25 Ingrid Lea Scully, Lisa Kristin McNeil, Sudam Pathirana, Christine Lee Singer, Yongdong Liu, Stanley Mullen, Douglas Girgenti, Alejandra Gurtman, Michael W. Pride, Kathrin Ute Jansen, Paul L. Huang, Annaliesa S. Anderson
Correction: Scully et al. Diabetol Metab Syndr (2017) 9:76 https://doi.org/10.1186/s13098-017-0276-3 After publication we became aware that the Acknowledgements section in our article [1] was incomplete. It should read as follows: “Medical writing support was provided by Sharmila Blows, Ph.D., of Engage Scientific Solutions, and was funded by Pfizer. We thank Johanna Hoyos for performing the chemotaxis
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Correction: Clinical inertia in newly diagnosed type 2 diabetes mellitus among patients attendingselected healthcare institutions in Colombia Diabetol. Metab. Syndr. (IF 4.8) Pub Date : 2024-03-25 Nelson Alvis-Guzman, Martín Romero, Fernando Salcedo-Mejia, Maria Carrasquilla-Sotomayor, Lina Gomez, Mónica María Rojas, Juan Camilo Urrego, Claudia Catalina Beltrán, Jaime Enrique Ruíz, Adriana Velásquez, Juan Carlos Orengo, Adolfo Pinzón
Correction: Diabetology & Metabolic Syndrome (2024) 16:42 https://doi.org/10.1186/s13098-023-01245-0 The copyright holder for this article was incorrectly given as “Battelle Memorial Institute, under exclusive licence to Springer Nature Switzerland AG 2024” but should have been “© Merck & Co., Inc., Rahway, NJ, USA and its affiliates and Nelson Alvis- Guzman, Martín Romero, Fernando Salcedo-Mejia,
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Combined impact of alcohol consumption and metabolic syndrome on liver dysfunction in an elderly Chinese population Diabetol. Metab. Syndr. (IF 4.8) Pub Date : 2024-03-23 Yanrong Zhao, Xiaoxue Yuan, Tianxiang Lin, Qing Yang, Xuewen Jiang, Song Yang, Yinwei Qiu
Alcohol consumption and metabolic syndrome(MetS), both prevalent in the general population, frequently co-occur. They are recognized as significant contributors to liver dysfunction, yet their combined effect is often challenging to delineate. This study delves into the compounding influence of alcohol consumption and metabolic disorder on liver dysfunction within an elderly demographic in Zhejiang
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Humanistic burden of pediatric type 1 diabetes on children and informal caregivers: systematic literature reviews Diabetol. Metab. Syndr. (IF 4.8) Pub Date : 2024-03-21 Veleka Allen, Aymeric Mahieu, Ellen Kasireddy, Walid Shouman, Mir-Masoud Pourrahmat, Jean-Paul Collet, Andriy Cherkas
Diagnosis of children with type 1 diabetes (T1D) imposes an unprecedented burden on children and their caregivers. To assess the burden of T1D on children and their informal caregivers, both after a recent diagnosis or after a longer duration of disease. A series of systematic literature reviews were performed to explore the burden of T1D on children with the disease and their primary informal caregivers
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Correction: Toe brachial index and not ankle brachial index is appropriate in initial evaluation of peripheral arterial disease in type 2 diabetes Diabetol. Metab. Syndr. (IF 4.8) Pub Date : 2024-03-21 Pankaj Singhania, Tapas Chandra Das, Chiranjit Bose, Asif Mondal, Rana Bhattacharjee, Archana Singh, Satinath Mukhopadhyay, Subhankar Chowdhury
Correction: Diabetology & Metabolic Syndrome (2024)16: 52 https://doi.org/10.1186/s13098-024-01291-2 Following publication of the original article [1], the authors would like to correct the number 0.9 in the conclusion under the main heading of abstract. The sentence currently reads: The sentence should read: Singhania P, Das TC, Bose C, et al. Toe brachial index and not ankle brachial index is appropriate
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Multiply restimulated human cord blood-derived Tregs maintain stabilized phenotype and suppressive function and predict their therapeutic effects on autoimmune diabetes Diabetol. Metab. Syndr. (IF 4.8) Pub Date : 2024-03-21 Yuanjie Bi, Ran Kong, Yani Peng, Donghua Cai, Yu Zhang, Fan Yang, Xia Li, Wen Deng, Fang Liu, Binbin He, Chuqing Cao, Chao Deng, Xiaohan Tang, Li Fan, Haibo Yu, Zhiguang Zhou
Regulatory T cells (Tregs) are involved in the maintenance of immune homeostasis and immune regulation. Clinical trials on the adoptive transfer of Tregs have been ongoing for > 10 years. However, many unresolved issues remain in the production of readymade Treg products and selection of patients. Hence, this study aimed to develop a method to expand off-the-shelf Tregs derived from umbilical cord
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Correlation between time in range and serum uric acid in Chinese patients with type-2 diabetes: an observational cross-sectional study Diabetol. Metab. Syndr. (IF 4.8) Pub Date : 2024-03-21 Yan Liu, Xiaoren Peng, Chunjian Qiu, Jiaqing Shao
At present, the relationship between serum uric acid and blood glucose is controversial, and even opposite conclusions have been reached. We aimed to investigate the relationship between time in range and serum uric acid and estimate the influence of serum uric acid on blood glucose fluctuations in Chinese patients with type-2 diabetes mellitus (T2DM). A total of 458 hospitalized patients with T2DM
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Increased stress hyperglycemia ratio at hospital admission in stroke patients are associated with increased in-hospital mortality and length of stay Diabetol. Metab. Syndr. (IF 4.8) Pub Date : 2024-03-16 Di Shen, Xintian Cai, Qing Zhu, Mulalibieke Heizhati, Junli Hu, Shuaiwei Song, Wenbo Yang, Jing Hong, Nanfang Li
Recently, the stress hyperglycemia ratio (SHR) has been introduced as a metric to signify relative hyperglycemia. This study aimed to investigate the relationship between SHR and in-hospital mortality and length of stay occurring during hospitalization in stroke patients. The retrospective cohort study comprised a total of 4,018 patients diagnosed with acute stroke. The SHR is expressed by the formula:
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Predictive value of insulin resistance surrogates for the development of diabetes in individuals with baseline normoglycemia: findings from two independent cohort studies in China and Japan Diabetol. Metab. Syndr. (IF 4.8) Pub Date : 2024-03-16 Qing Shangguan, Qiuling Liu, Ruijuan Yang, Shuhua Zhang, Guotai Sheng, Maobin Kuang, Yang Zou
Insulin resistance (IR) plays a crucial role in the occurrence and progression of diabetes. This study aimed to evaluate and compare the predictive value of four IR surrogates, including the triglycerides glucose (TyG) index, TyG and body mass index (TyG-BMI), triglycerides/high-density lipoprotein cholesterol (TG/HDL-C) ratio, and the metabolic score for IR (MetS-IR) for diabetes in two large cohorts
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Predictive effect of triglyceride-glucose index on No-Reflow Phenomenon in patients with type 2 diabetes mellitus and acute myocardial infarction undergoing primary percutaneous coronary intervention Diabetol. Metab. Syndr. (IF 4.8) Pub Date : 2024-03-14 Juan Ma, Mohan Wang, Peng Wu, Xueping Ma, Dapeng Chen, Shaobin Jia, Ning Yan
Triglyceride glucose (TyG) index is considered as a new alternative marker of insulin resistance and a clinical predictor of type 2 diabetes mellitus (T2DM) combined with coronary artery disease. However, the prognostic value of TyG index on No-Reflow (NR) Phenomenon in T2DM patients with acute myocardial infarction (AMI) remains unclear. In this retrospective study, 1683 patients with T2DM and AMI
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Large-scale causal analysis of gut microbiota and six common complications of diabetes: a mendelian randomization study Diabetol. Metab. Syndr. (IF 4.8) Pub Date : 2024-03-13 Jiachen Wang, Menghao Teng, Ruoyang Feng, Xiaochen Su, Ke Xu, Junxiang Wang, Guoqiang Wang, Yulong Zhang, Peng Xu
This study aimed to reveal the association between the gut microbiota (GM) and six diabetic complications: diabetic hypoglycemia; ketoacidosis; nephropathy; neuropathy; retinopathy; and Charcot’s foot. GM data were obtained from the MiBioGen consortium and Dutch Microbiome Project while data on the six diabetic complications were obtained from the FinnGen consortium. Two-sample Mendelian randomization
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Remnant cholesterol, iron status and diabetes mellitus: a dose–response relationship and mediation analysis Diabetol. Metab. Syndr. (IF 4.8) Pub Date : 2024-03-12 Xiangming Hu, Yan Lin, Allison A. Appleton, Weimian Wang, Bingyan Yu, Langping Zhou, Guang Li, Yingling Zhou, Yanqiu Ou, Haojian Dong
Remnant cholesterol (RC) is recognized as a risk factor for diabetes mellitus (DM). Although iron status has been shown to be associated with cholesterol metabolism and DM, the association between RC, iron status, and DM remains unclear. We examined the relationship between RC and iron status and investigated the role of iron status in the association between RC and DM. A total of 7308 patients were
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Epidemiological and transcriptome data identify shared gene signatures and immune cell infiltration in type 2 diabetes and non-small cell lung cancer Diabetol. Metab. Syndr. (IF 4.8) Pub Date : 2024-03-12 Qian Yuan, Long Li, Liu-shun Wang, Shi-gui Xing
Numerous previous studies have reported an association between type 2 diabetes mellitus (T2DM) and lung cancer risk, but the underlying mechanism of the interaction remains unclear. This study aimed to investigate the shared genetic features and immune infiltration processes between lung cancer and T2DM. Epidemiological data from the National Health and Nutrition Examination Survey (NHANES) 2000–2018
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Association between insulin resistance, metabolic syndrome and its components and lung cancer: a systematic review and meta-analysis Diabetol. Metab. Syndr. (IF 4.8) Pub Date : 2024-03-11 Jingxuan Liu, Rui Wang, Song Tan, Xiaohu Zhao, Aihua Hou
A growing body of evidence points to the association between insulin resistance (IR), metabolic syndrome (MetS) and its components and lung cancer incidence, but remains controversial and unknown. A systematic search was conducted through PubMed, Embase, Cochrane Library, the China National Knowledge Infrastructure (CNKI) and Wanfang databases for the corresponding studies. Each study reported the
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Association between insulin receptor substrate 1 gene polymorphism rs1801278 and gestational diabetes mellitus: an updated meta- analysis Diabetol. Metab. Syndr. (IF 4.8) Pub Date : 2024-03-06 Lili Shen, Junli Liu, Xiaolei Zhao, Aiqin Wang, Xiaomei Hu
we performed this meta- analysis to investigate the impact of insulin receptor substrate 1 (IRS1) gene rs1801278 on susceptibility to gestational diabetes mellitus (GDM). The pooled odds ratio (OR) and 95% confidence interval (95% CI) were calculated, and p value is used to determine statistical significance. Sensitivity analysis was performed under three models (dominant, recessive and allele model)
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Two ferroptosis-specific expressed genes NOX4 and PARP14 are considered as potential biomarkers for the diagnosis and treatment of diabetic retinopathy and atherosclerosis Diabetol. Metab. Syndr. (IF 4.8) Pub Date : 2024-03-05 Chen Li, QinHua Cai
Both Diabetic retinopathy (DR) and Atherosclerosis (AS) are common complications in patients with diabetes, and they share major pathophysiological similarities and have a common pathogenesis. Studies performed to date have demonstrated that ferroptosis plays a vital part in the occurrence and development of DR and AS, but its mechanism in the two diseases remains poorly understood. DR Chip data (GSE60436
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Associations between type 1 diabetes and pulmonary tuberculosis: a bidirectional mendelian randomization study Diabetol. Metab. Syndr. (IF 4.8) Pub Date : 2024-03-05 Yijia Jiang, Wenhua Zhang, Maoying Wei, Dan Yin, Yiting Tang, Weiyu Jia, Churan Wang, Jingyi Guo, Aijing Li, Yanbing Gong
Type 1 diabetes mellitus (T1DM) has been associated with higher pulmonary tuberculosis (PTB) risk in observational studies. However, the causal relationship between them remains unclear. This study aimed to assess the causal effect between T1DM and PTB using bidirectional Mendelian randomization (MR) analysis. Single nucleotide polymorphisms (SNPs) of T1DM and PTB were extracted from the public genetic
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Causal relationship between diabetes mellitus, glycemic traits and Parkinson’s disease: a multivariable mendelian randomization analysis Diabetol. Metab. Syndr. (IF 4.8) Pub Date : 2024-03-05 Qitong Wang, Benchi Cai, Lifan Zhong, Jitrawadee Intirach, Tao Chen
Observational studies have indicated an association between diabetes mellitus (DM), glycemic traits, and the occurrence of Parkinson’s disease (PD). However, the complex interactions between these factors and the presence of a causal relationship remain unclear. Therefore, we aim to systematically assess the causal relationship between diabetes, glycemic traits, and PD onset, risk, and progression
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Prognostic significance of the stress hyperglycemia ratio and admission blood glucose in diabetic and nondiabetic patients with spontaneous intracerebral hemorrhage Diabetol. Metab. Syndr. (IF 4.8) Pub Date : 2024-03-04 Shengru Liang, Xiaoxi Tian, Fei Gao, Minghao Man, Qi Wang, Jianwei Li, Lihong Li, Yang Yang
The role of stress hyperglycemia ratio (SHR) on the prognosis of spontaneous intracerebral hemorrhage (ICH) in patients with different diabetic status has not been elucidated. This study aimed to evaluate the prognostic value of SHR and admission blood glucose (ABG) for the short- and long-term mortality in diabetic and nondiabetic populations with ICH. Participants with ICH were retrospectively retrieved
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Gestational diabetes mellitus aggravates adverse perinatal outcomes in women with intrahepatic cholestasis of pregnancy Diabetol. Metab. Syndr. (IF 4.8) Pub Date : 2024-03-01 Xia Li, Qin-Yu Cai, Xin Luo, Yong-Heng Wang, Li-Zhen Shao, Shu-Juan Luo, Lan Wang, Ying-Xiong Wang, Xia Lan, Tai-Hang Liu
To evaluate the effect of intrahepatic cholestasis of pregnancy (ICP) with gestational diabetes mellitus (GDM) on perinatal outcomes and establish a prediction model of adverse perinatal outcomes in women with ICP. This multicenter retrospective cohort study included the clinical data of 2,178 pregnant women with ICP, including 1,788 women with ICP and 390 co-occurrence ICP and GDM. The data of all
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Assessing the temporal within-day glycemic variability during hospitalization in patients with type 2 diabetes patients using continuous glucose monitoring: a retrospective observational study Diabetol. Metab. Syndr. (IF 4.8) Pub Date : 2024-03-01 Ying Xing, Min Wu, Hongping Liu, Penghui Li, Guoming Pang, Hui Zhao, Tiancai Wen
Frequent and extensive within-day glycemic variability (GV) in blood glucose levels may increase the risk of hypoglycemia and long-term mortality in hospitalized patients with diabetes. We aimed to assess the amplitude and frequency of within-day GV in inpatients with type 2 diabetes and to explore the factors influencing within-day GV. We conducted a single-center, retrospective observational study
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Clinical outcomes of simultaneous pancreas-kidney transplantation in elderly type II diabetic recipients Diabetol. Metab. Syndr. (IF 4.8) Pub Date : 2024-02-29 Yu Cao, Jie Zhao, Gang Feng, Zhen Wang, Jianghao Wei, Yang Xu, Chunbai Mo, Wenli Song
The effect of age on outcomes after simultaneous pancreas-kidney transplantation (SPK) among type II diabetes (T2DM) recipients remains inconclusive. This study aimed to analyze the relationship between the age at time of transplantation and mortality, graft loss and metabolic profiles of T2DM SPK recipients. A retrospective cohort consisting of T2MD SPK recipients in a single transplant center was
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Correction: 2024 UPDATE: the Brazilian Diabetes Society position on the management of metabolic dysfunction‑associated steatotic liver disease (MASLD) in people with prediabetes or type 2 diabetes Diabetol. Metab. Syndr. (IF 4.8) Pub Date : 2024-02-28 Amélio F. Godoy‑Matos, Cynthia Melissa Valério, Wellington S. Silva Júnior, João Marcello de Araujo‑Neto, Marcello Casaccia Bertoluci
Correction: Diabetology & Metabolic Syndrome (2024) 16:23 https://doi.org/10.1186/s13098‑024‑01259‑2 The colour of the recommendation 8 should be changed from green to orange and the number to be changed from 1 to 11b. The original article [1] has been corrected. Changed from to Godoy‑Matos AF, Valério CM, Silva Júnior WS, de Araujo-Neto JM, Bertoluci MC. 2024 UPDATE: the Brazilian Diabetes Society
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First-trimester HbA1c in relation to plasma glucose concentrations in an oral glucose tolerance test at 12 to 16 weeks’ gestation—a population-based study Diabetol. Metab. Syndr. (IF 4.8) Pub Date : 2024-02-27 Mervi Jokelainen, Hannu Kautiainen, Arja Nenonen, Beata Stach-Lempinen, Miira M. Klemetti
Early-onset GDM often requires pharmacological treatment and is associated with adverse perinatal outcomes, but data is insufficient regarding the best methods to identify high-risk women requiring early GDM screening. The aim of this study was to analyze the diagnostic accuracy of HbA1c in the prediction of (1) plasma glucose concentrations > 90th percentile in an oral glucose tolerance test (OGTT)
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Toe brachial index and not ankle brachial index is appropriate in initial evaluation of peripheral arterial disease in type 2 diabetes Diabetol. Metab. Syndr. (IF 4.8) Pub Date : 2024-02-27 Pankaj Singhania, Tapas Chandra Das, Chiranjit Bose, Asif Mondal, Rana Bhattacharjee, Archana Singh, Satinath Mukhopadhyay, Subhankar Chowdhury
Non-invasive clinic-based tools for assessing PAD are not without limitations. Therefore, costly tests like Doppler study, CT angiography and MR angiography are often required to make a diagnosis. Ankle brachial index (ABI), commonly used for assessment of PAD, has high false positivity rates in sclerosed, calcified arteries which render them non-compressible. Toe brachial index (TBI) can be an alternative
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Increased susceptibility to new-onset atrial fibrillation in diabetic women with poor sleep behaviour traits: findings from the prospective cohort study in the UK Biobank Diabetol. Metab. Syndr. (IF 4.8) Pub Date : 2024-02-27 Siwei Chen, Zhou Liu, Shaohua Yan, Zhongyan Du, Wenke Cheng
Diabetic individuals often encounter various sleep-related challenges. Although the association between sleep duration and atrial fibrillation (AF) have been explored, the association of other sleep traits with the incidence of AF remains unclear. A comprehensive understanding of these traits is essential for a more accurate assessment of sleep conditions in patients with diabetes and the development
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High dietary inflammatory index associates with inflammatory proteins in plasma Diabetol. Metab. Syndr. (IF 4.8) Pub Date : 2024-02-26 Elisa Mattavelli, Elisa Piperni, Francesco Asnicar, Laura Redaelli, Liliana Grigore, Fabio Pellegatta, Amir Nabinejad, Sabrina Tamburini, Nicola Segata, Alberico Luigi Catapano, Andrea Baragetti
Unhealthy dietary habits and highly caloric foods induce metabolic alterations and promote the development of the inflammatory consequences of obesity, insulin resistance, diabetes and cardiovascular diseases. Describing an inflammatory effect of diet is difficult to pursue, owing lacks of standardized quali-quantitative dietary assessments. The Dietary Inflammatory Index (DII) has been proposed as
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Single-cell RNA sequencing reveals roles of unique retinal microglia types in early diabetic retinopathy Diabetol. Metab. Syndr. (IF 4.8) Pub Date : 2024-02-26 Yan Wang, Xiongyi Yang, Yuxi Zhang, Libing Hong, Zhuohang Xie, Wenmin Jiang, Lin Chen, Ke Xiong, Siyu Yang, Meiping Lin, Xi Guo, Qiumo Li, Xiaoqing Deng, Yanhui Lin, Mingzhe Cao, Guoguo Yi, Min Fu
The pathophysiological mechanisms of diabetic retinopathy (DR), a blinding disease, are intricate. DR was thought to be a microvascular disease previously. However, growing studies have indicated that the retinal microglia-induced inflammation precedes microangiopathy. The binary concept of microglial M1/M2 polarization paradigms during inflammatory activation has been debated. In this study, we confirmed
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Comparative effectiveness of different modes of exercise interventions in diabetics with frailty in China: a systematic review and a network meta-analysis Diabetol. Metab. Syndr. (IF 4.8) Pub Date : 2024-02-26 Liu Qin, Peng Junjie, Wei Xinhong, Fang Shengju, Sun Ruifen
To systematically evaluate the efficacy of different training modes in patients with diabetes decline. PubMed, Cochrane Library, EMbase, Web of Science, CNKI, VIP, WANFANG, SinoMed were searched in computer to collect randomized controlled trials (RCTs) of training intervention in patients with diabetes and frailty, and the search time was as of May 21, 2023. After two review authors independently
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Role of gastric bypass surgery in control of blood sugar in obese uncontrolled type 2 diabetic patients Diabetol. Metab. Syndr. (IF 4.8) Pub Date : 2024-02-19 Hala Khalf Allah El-Shreef, Osama Yaseen Mostafa Taha, Heba Elsayed Ahmed Abdellatif, Amal Ibrahim Abd El-Rheem Abo Shoka
The pandemic of the twenty-first century is diabetes. Both type 2 diabetes mellitus and obesity pose severe problems for public health. Despite significant improvements in diagnosing and managing both conditions, diabetes mellitus remains poorly controlled, and diabetic complications are more common than ever. Internists have discovered over the past 20 years that obese people with type 2 diabetes
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SGLT2i relieve proteinuria in diabetic nephropathy patients potentially by inhibiting renal oxidative stress rather than through AGEs pathway Diabetol. Metab. Syndr. (IF 4.8) Pub Date : 2024-02-16 Xiao-chun Zeng, Yuan Tian, Xian-ming Liang, Xiao-bin Wu, Chun-meng Yao, Xiao-min Chen
To estimate the effects of the sodium-glucose cotransporter 2 inhibitor (SGLT2i) on proteinuria and oxidative stress expression in type 2 diabetes patients. 68 patients with type 2 diabetes mellitus (T2DM) were divided into three groups according urinary albumin-to-creatinine ratio (UACR), including T2DM with non-albuminuria group (UACR < 30 mg/g), T2DM with microalbuminuria group (30 ≤ UACR ≤ 300 mg/g)
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The intervention of cannabinoid receptor in chronic and acute kidney disease animal models: a systematic review and meta-analysis Diabetol. Metab. Syndr. (IF 4.8) Pub Date : 2024-02-15 Zihao Zhao, Qianqian Yan, Junwei Xie, Zhenjie Liu, Fengxun Liu, Yong Liu, Sijie Zhou, Shaokang Pan, Dongwei Liu, Jiayu Duan, Zhangsuo Liu
Cannabinoid receptors are components of the endocannabinoid system that affect various physiological functions. We aim to investigate the effect of cannabinoid receptor modulation on kidney disease. PubMed, Web of Science databases, and EMBASE were searched. Articles selection, data extraction and quality assessment were independently performed by two investigators. The SYRCLE’s RoB tool was used to
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Stress-induced hyperglycemia is associated with the mortality of thrombotic thrombocytopenic purpura patients Diabetol. Metab. Syndr. (IF 4.8) Pub Date : 2024-02-15 Lingling Hu, Jing Wang, Xiaxia Jin, Guoguang Lu, Meidan Fang, Jian Shen, Tao-Hsin Tung, Bo Shen
Thrombotic thrombocytopenic purpura (TTP) is a rare thrombotic microangiopathy with a rapid progression and high mortality rate. We aimed to explore early risk factors for mortality in patients with TTP. We conducted a retrospective analysis of 42 TTP patients that were admitted to our hospital between 2000 and 2021, with a median age of 49 (29–63) years. Risk factors for mortality were evaluated using
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Global trends and developments in mindfulness interventions for diabetes: a bibliometric study Diabetol. Metab. Syndr. (IF 4.8) Pub Date : 2024-02-15 Sijia Jiang, Xiaoli Pan, Hansen Li, Yuqin Su
Diabetes is a metabolic disorder posing a global threat to health. Many scholars are dedicated to developing non-pharmacological therapies, and mindfulness intervention is among the potentially effective approaches. Due to the rapid increase in relevant research in recent years, along with the diverse focus and interventions used in studies, it has become challenging for practitioners to quickly comprehend
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Clinical inertia in newly diagnosed type 2 diabetes mellitus among patients attending selected healthcare institutions in Colombia Diabetol. Metab. Syndr. (IF 4.8) Pub Date : 2024-02-15 Nelson Alvis-Guzman, Martín Romero, Fernando Salcedo-Mejia, Maria Carrasquilla-Sotomayor, Lina Gómez, Mónica María Rojas, Juan Camilo Urrego, Claudia Catalina Beltrán, Jaime Enrique Ruíz, Adriana Velásquez, Juan Carlos Orengo, Adolfo Pinzón
The burden of disease of diabetes in Colombia have increased in the last decades. Secondary prevention is crucial for diabetes control. Many patients already treated remain with poor glycemic control and without timely and appropriate treatment intensification. This has been called in the literature as Clinical Inertia. Updated information regarding clinical inertia based on the Colombian diabetes
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Early signs of myocardial systolic dysfunction in patients with type 2 diabetes are strongly associated with myocardial microvascular dysfunction independent of myocardial fibrosis: a prospective cohort study Diabetol. Metab. Syndr. (IF 4.8) Pub Date : 2024-02-13 Annemie S. Bojer, Martin H. Sørensen, Stine H. Madsen, David A. Broadbent, Sven Plein, Peter Gæde, Per L. Madsen
Patients with diabetes demonstrate early left ventricular systolic dysfunction. Notably reduced global longitudinal strain (GLS) is related to poor outcomes, the underlying pathophysiology is however still not clearly understood. We hypothesized that pathophysiologic changes with microvascular dysfunction and interstitial fibrosis contribute to reduced strain. 211 patients with type 2 diabetes and
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Sacubitril/valsartan ameliorates tubulointerstitial fibrosis by restoring mitochondrial homeostasis in diabetic kidney disease Diabetol. Metab. Syndr. (IF 4.8) Pub Date : 2024-02-10 Xing-Jian Zhang, Cong-Cong Liu, Zuo-Lin Li, Lin Ding, Yan Zhou, Dong-Jie Zhang, Yao Zhang, Shu-Ting Hou, Rui-Xia Ma
Tubulointerstitial fibrosis plays an important role in the progression of diabetic kidney disease (DKD). Sacubitril/valsartan (Sac/Val) exerts a robust beneficial effect in DKD. However, the potential functional effect of Sac/Val on tubulointerstitial fibrosis in DKD is still largely unclear. Streptozotocin-induced diabetic mice were given Sac/Val or Val by intragastric administration once a day for
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Pancreatic enzyme replacement therapy in subjects with exocrine pancreatic insufficiency and diabetes mellitus: a real-life, case–control study Diabetol. Metab. Syndr. (IF 4.8) Pub Date : 2024-02-09 Laure Alexandre-Heymann, Fetta Yaker, Pierre Bel Lassen, Danièle Dubois-Laforgue, Etienne Larger
Exocrine pancreatic insufficiency (EPI) can be associated with all types of diabetes. Pancreatic enzyme replacement therapy (PERT) has short and long-term benefits in subjects with EPI, but its effects on diabetes control are uncertain. We aimed to study the effects of PERT initiation on glycemic control in subjects with diabetes and EPI from any cause. In this retrospective study, we compared subjects
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Dapagliflozin improves podocytes injury in diabetic nephropathy via regulating cholesterol balance through KLF5 targeting the ABCA1 signalling pathway Diabetol. Metab. Syndr. (IF 4.8) Pub Date : 2024-02-07 Jingshu Sun, Xinyu Zhang, Simeng Wang, Dandan Chen, Jianqiang Shu, Nannan Chong, Qinglian Wang, Ying Xu
Diabetic nephropathy (DN), one of the more prevalent microvascular complications in patients diagnosed with diabetes mellitus, is attributed as the main cause of end-stage renal disease (ESRD). Lipotoxicity in podocytes caused by hyperglycemia has been recognised as a significant pathology change, resulting in the deterioration of the glomerular filtration barrier. Research has demonstrated how dapagliflozin
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Exosomes derived from BMSCs enhance diabetic wound healing through circ-Snhg11 delivery Diabetol. Metab. Syndr. (IF 4.8) Pub Date : 2024-02-07 Tao Tang, Linyi Chen, Ming Zhang, Chuang Wang, Xiaolong Du, Shenglin Ye, Xiaoqiang Li, Hong Chen, Nan Hu
Exosomes (Exos) generated from bone mesenchymal stem cells (BMSCs) are elucidated to enhance cutaneous wound healing in mice models of diabetes mellitus (DM). While underlying mechanisms remain unknown. Next-generation sequencing (NGS) was used to examine changes in circRNA expression levels following Exo treatment. Luciferase assays were used to determine the interactions between RNAs. Immunofluorescence
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Correction: The interrelationship and accumulation of cardiometabolic risk factors amongst young adults in the United Arab Emirates: The UAE Healthy Future Study Diabetol. Metab. Syndr. (IF 4.8) Pub Date : 2024-02-07 Fatima Mezhal, Abderrahim Oulhaj, Abdishakur Abdulle, Abdulla AlJunaibi, Abdulla Alnaeemi, Amar Ahmad, Andrea Leinberger‑Jabari, Ayesha S. Al Dhaheri, E. Murat Tuzcu, Eiman AlZaabi, Fatma Al‑Maskari, Fatme Alanouti, Fayza Alameri, Habiba Alsafar, Hamad Alblooshi, Juma Alkaabi, Laila Abdel Wareth, Mai Aljaber, Marina Kazim, Micheal Weitzman, Mohammad Al‑Houqani, Mohammad Hag Ali, Naima Oumeziane, Omar
Correction: Diabetology & Metabolic Syndrome (2021) 13:140 https://doi.org/10.1186/s13098-021-00758-w Following publication of the original article [1], the authors identified an error in Table 3. The word “Dyslipidemia” should be removed from Hypertension column. The correct Table 3 is given below. Table 3 Odd ratios of the associations between the cardiometabolic risk factors adjusted for age and