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Intracortical microstimulation of human somatosensory cortex is sufficient to induce perceptual biases medRxiv. Neurol. Pub Date : 2024-04-22 Charles M. Greenspon, Natalya D. Shelchkova, Taylor G. Hobbs, Sliman J. Bensmaia, Robert A. Gaunt
Time-order error, a psychophysical phenomenon in which the duration in between successive stimuli alters perception, has been studied for decades by neuroscientists and psychologists. To date, however, the locus of these effects is unknown. We use intracortical microstimulation of somatosensory cortex in humans as a tool to bypass initial stages of processing and restrict the possible locations that
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Energetically costly functional network dynamics in cognitively impaired multiple sclerosis patients medRxiv. Neurol. Pub Date : 2024-04-22 T.A.A. Broeders, M. van Dam, G. Pontillo, V. Rauh, L. Douw, Y.D. van der Werf, J. Killestein, F. Barkhof, C.H. Vinkers, M.M. Schoonheim
Background and objectives Patients with multiple sclerosis (MS) often experience cognitive impairment, and this is related to structural disconnection and subsequent functional reorganization. It is not clear how specific patterns of functional reorganization might make it harder for cognitively impaired (CI) MS patients to dynamically adapt how brain regions communicate, which is crucial for normal
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A Machine Learning Classification of Individuals with Mild Cognitive Impairment into Variants from Writing medRxiv. Neurol. Pub Date : 2024-04-22 Hana Kim, Argye Hillis, Charalambos Themistocleous
Introduction Individuals with Mild Cognitive Impairment (MCI), a transitional stage between cognitively healthy aging and dementia, are characterized by subtle neurocognitive changes. Clinically, they can be grouped into two main variants, namely into patients with amnestic MCI (aMCI) and non-amnestic MCI (naMCI). The distinction of the two variants is known to be clinically significant as they exhibit
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Aging-dependent Change in Th17 and Cytokine Response in Multiple Sclerosis medRxiv. Neurol. Pub Date : 2024-04-22 Wen Zhu, Shankar Revu, Chenyi Chen, Megan Dahl, Archana Ramkumar, Conor Kelly, Mandy J McGeachy, Zongqi Xia
Background Multiple sclerosis (MS) is a chronic autoimmune disease damaging the central nervous system. Diminished inflammatory disease activities (DAs) as people with MS (pwMS) age justified randomized clinical trials assessing disease-modifying therapy (DMT) discontinuation in older pwMS given the concern for risks outweighing benefits.
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Towards cascading genetic risk in Alzheimer’s disease medRxiv. Neurol. Pub Date : 2024-04-21 Andre Altmann, Leon M Aksman, Neil P Oxtoby, Alexandra Young, ADNI, Daniel C Alexander, Frederik Barkhof, Maryam Shoai, John Hardy, Jonathan M Schott
Alzheimer’s disease typically progresses in stages, which have been defined by the presence of disease-specific biomarkers: Amyloid (A), Tau (T) and neurodegeneration (N). This progression of biomarkers has been condensed into the ATN framework, where each of the biomarkers can be either positive (+) or negative (-). Over the past decades genome wide association studies have implicated about 90 different
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A Case for Estradiol: Younger Brains in Women with Earlier Menarche and Later Menopause medRxiv. Neurol. Pub Date : 2024-04-20 Eileen Luders, Inger Sundström Poromaa, Claudia Barth, Christian Gaser
The transition to menopause is marked by a gradual decrease of estradiol. At the same time, the risk of dementia increases around menopause and it stands to reason that estradiol (or the lack thereof) plays a significant role for the development of dementia and other age-related neuropathologies. Here we investigated if there is a link between brain aging and estradiol-associated events, such as menarche
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Baseline functional connectivity predicts who will benefit from neuromodulation: evidence from primary progressive aphasia medRxiv. Neurol. Pub Date : 2024-04-20 Zeyi Wang, Jessica Gallegos, Donna Tippett, Chiadi U Onyike, John E Desmond, Argye E Hillis, Constantine E Frangakis, Brian Caffo, Kyrana Tsapkini
Background Identifying the characteristics of individuals who demonstrate response to an intervention allows us to predict who is most likely to benefit from certain interventions. Prediction is challenging in rare and heterogeneous diseases, such as primary progressive aphasia (PPA), that have varying clinical manifestations. We aimed to determine the characteristics of those who will benefit most
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Dynamic reconfiguration of aperiodic brain activity supports cognitive functioning in epilepsy: a neural fingerprint identification medRxiv. Neurol. Pub Date : 2024-04-20 Emahnuel Troisi Lopez, Marie-Constance Corsi, Alberto Danieli, Lisa Antoniazzi, Marianna Angiolelli, Paolo Bonanni, Pierpaolo Sorrentino, Gian Marco Duma
Background Temporal lobe epilepsy (TLE) is characterized by alterations of brain dynamic at large scale associated with altered cognitive functioning. Interindividual variability of brain activity is a source of heterogeneity in this disorder. Here, we aimed at analyzing dynamical reconfiguration of brain activity, using the neural fingerprint approach, to delineate subject-specific characteristics
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Protocol for a seamless phase 2A-phase 2B randomized double-blind placebo-controlled trial to evaluate the safety and efficacy of benfotiamine in patients with early Alzheimer’s disease (BenfoTeam) medRxiv. Neurol. Pub Date : 2024-04-19 Howard H. Feldman, José A. Luchsinger, Gabriel C. Léger, Curtis Taylor, Diane M. Jacobs, David P. Salmon, Steven D. Edland, Karen Messer, Carolyn Revta, Sarah A. Flowers, Kerry S. Jones, Albert Koulman, Kevin E. Yarasheski, Philip B. Verghese, Venky Venkatesh, Henrik Zetterberg, January Durant, Jody-Lynn Lupo, Gary E. Gibson, the ADCS BenfoTeam Study Group
Background Benfotiamine provides an important novel therapeutic direction in Alzheimer’s disease (AD) with possible additive or synergistic effects to amyloid targeting therapeutic approaches.
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Pharmacodynamic effects of semorinemab on plasma and CSF biomarkers of Alzheimer’s disease pathophysiology medRxiv. Neurol. Pub Date : 2024-04-19 Stephen Schauer, Balazs Toth, Julie Lee, Lee A. Honigberg, Vidya Ramakrishnan, Jenny Jiang, Gwendlyn Kollmorgen, Anna Bayfield, Norbert Wild, Jennifer Hoffman, Ryan Ceniceros, Michael Dolton, Sandra Sanabria Bohorquez, Casper C. Hoogenraad, Kristin R. Wildsmith, Edmond Teng, Cecilia Monteiro, Veronica Anania, Felix L. Yeh
INTRODUCTION Semorinemab, an anti-tau monoclonal antibody, was evaluated in two Phase II trials as a disease-modifying treatment for Alzheimer’s disease (AD). Plasma and cerebrospinal fluid (CSF) samples were collected from trial participants to evaluate the pharmacodynamic effects of semorinemab and elucidate its mechanism of action.
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Cognitive training reshapes functional lateralization of fronto-parietal network in patients with vascular cognitive impairment no dementia medRxiv. Neurol. Pub Date : 2024-04-19 Xinhu Jin, Yi Xing, Baihan Lyu, Xiuyi Wang, Yi Tang, Yi Du
Background and Objectives Vascular cognitive impairment no dementia represents cognitive deficits due to vascular causes but falls short of a dementia diagnosis. Cognitive training has emerged as a safe and effective intervention for vascular cognitive impairment no dementia, though its underlying mechanisms remain obscure. This study investigates how subcortical vascular cognitive impairment no dementia
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Gamified closed-loop non-pharmacological intervention enhances tic suppression in children medRxiv. Neurol. Pub Date : 2024-04-19 Michael S. Rotstein, Sharon Zimmerman-Brenner, Shiri Davidovitch, Yael Ben-Haim, Yuval Koryto, Romi Sion, Einat Rubinstein, Meshi Djerassi, Nitzan Lubiniaker, Tamar Steinberg, Yael Leitner, Gal Raz
Background The gamification of behavioral intervention for tic disorders (TDs) may not only enhance compliance with treatment protocols but also offer a key clinical advantage. By providing immediate positive feedback when tics are suppressed, games can counteract negative reinforcement processes that reinforce tics, which assumingly alleviates unpleasant premonitory urges. We developed a gamified
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Default mode network tau predicts future clinical decline in atypical early Alzheimer’s disease medRxiv. Neurol. Pub Date : 2024-04-19 Yuta Katsumi, Inola A. Howe, Ryan Eckbo, Bonnie Wong, Megan Quimby, Daisy Hochberg, Scott M. McGinnis, Deepti Putcha, David A. Wolk, Alexandra Touroutoglou, Bradford C. Dickerson
Identifying individuals with early stage Alzheimer’s disease (AD) at greater risk of steeper clinical decline would allow professionals and loved ones to make better-informed medical, support, and life planning decisions. Despite accumulating evidence on the clinical prognostic value of tau PET in typical late-onset amnestic AD, its utility in predicting clinical decline in individuals with atypical
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Pilot trial of perampanel on peritumoral hyperexcitability and clinical outcomes in newly diagnosed high-grade glioma medRxiv. Neurol. Pub Date : 2024-04-18 Steven Tobochnik, Michael S. Regan, Maria K. C. Dorotan, Dustine Reich, Emily Lapinskas, Md Amin Hossain, Sylwia Stopka, Sandro Santagata, Melissa M. Murphy, Omar Arnaout, Wenya Linda Bi, E. Antonio Chiocca, Alexandra J. Golby, Michael A. Mooney, Timothy R. Smith, Keith L. Ligon, Patrick Y. Wen, Nathalie Y. R. Agar, Jong Woo Lee
Background Glutamatergic neuron-glioma synaptogenesis and peritumoral hyperexcitability promote glioma growth in a positive feedback loop. The objective of this study was to evaluate the feasibility and estimated effect sizes of the AMPA-R antagonist, perampanel, on intraoperative electrophysiologic hyperexcitability and clinical outcomes.
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The circulating proteome and brain health: Mendelian randomisation and cross-sectional analyses medRxiv. Neurol. Pub Date : 2024-04-16 Rosie M. Walker, Michael Chong, Nicolas Perrot, Marie Pigeyre, Danni A. Gadd, Aleks Stolicyn, Liu Shi, MA Archie Campbell, Xueyi Shen, Heather C. Whalley, Alejo Nevado-Holgado, Andrew M. McIntosh, Stefan Heitmeier, Sumathy Rangarajan, Martin O’Donnell, Eric E. Smith, Salim Yusuf, William N. Whiteley, Guillaume Paré
Decline in cognitive function is the most feared aspect of ageing. Poorer midlife cognitive function is associated with increased dementia and stroke risk. The mechanisms underlying variation in cognitive function are uncertain. Here, we assessed associations between 1160 proteins’ plasma levels and two measures of cognitive function, the digit symbol substitution test (DSST) and the Montreal Cognitive
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Plasma pTau181 reveals a pathological signature that predicts cognitive outcomes in Lewy body disease medRxiv. Neurol. Pub Date : 2024-04-15 Carla Abdelnour, Christina B Young, Marian Shahid-Besanti, Alena Smith, Edward N. Wilson, Javier Ramos Benitez, Hillary Vossler, Melanie J. Plastini, Joseph R. Winer, Geoffrey A. Kerchner, Brenna Cholerton, Katrin I. Andreasson, Victor W. Henderson, Maya Yutsis, Thomas J Montine, Lu Tian, Elizabeth C. Mormino, Kathleen L. Poston
Lewy body disease (LBD) often co-exists with Alzheimer’s disease (AD), influencing disease progression, cognitive decline, and neurodegeneration. This study aims to determine whether plasma phosphorylated-Tau181 (pTau181) could be used as diagnostic biomarker of concurrent Alzheimer’s disease neuropathologic change (ADNC) or amyloidosis alone, as well as a prognostic, monitoring, and susceptibility/risk
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Is ChatGPT Better Than Epileptologists at Interpreting Seizure Semiology? medRxiv. Neurol. Pub Date : 2024-04-15 Meng Jiao, Yaxi Luo, Neel Fotedar, Ioannis Karakis, Vikram R. Rao, Melissa Asmar, Xiaochen Xian, Orwa Aboud, Yuxin Wen, Jack J. Lin, Felix Rosenow, Hai Sun, Feng Liu
Importance Utilizing large language models (LLMs), primarily ChatGPT, to interpret the seizure semiology with focal epilepsy could yield valuable data for presurgical assessment. Assessing the reliability and comparability of LLM-generated responses with those from well-trained neurologists, especially epileptologists, is crucial for ascertaining the value of LLMs in the presurgical evaluation.
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Local field potential signal transmission is correlated with the anatomical connectivity measured by diffusion tractography medRxiv. Neurol. Pub Date : 2024-04-15 Maral Kasiri, Sumiko Abe, Rahil Sorouhmojdehi, Estefania Hernandez-Martin, S. Alireza Seyyed Mousavi, Terence D. Sanger
Objective In this paper we aim to examine the correlation between diffusion tensor imaging (DTI) parameters of anatomical connectivity and characteristics of signal transmission obtained from patient-specific transfer function models. Here, we focused on elucidating the correlation between structural and functional neural connectivity within a cohort of patients diagnosed with dystonia.
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CSF complement proteins are elevated in prodromal to moderate AD patients and are not altered by the anti-tau antibody semorinemab medRxiv. Neurol. Pub Date : 2024-04-15 Cosme Sandoval, Julie Lee, Balazs Toth, Rajini Nagaraj, Stephen Schauer, Jennifer Hoffman, Gwendlyn Kollmorgen, Cecilia Monteiro, Edmond Teng, Jesse E Hanson, Felix L Yeh, Johnny Gutierrez, Anne Biever
INTRODUCTION Growing evidence suggests a role for neuroinflammation in Alzheimer’s Disease (AD) pathogenesis. We investigated the complement system, a component of innate immunity, in AD patient cerebrospinal fluid (CSF) and evaluated its modulation by the anti-tau antibody semorinemab.
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Alignments between cortical neurochemical systems, proteinopathy and neurophysiological alterations along the Alzheimer’s disease continuum medRxiv. Neurol. Pub Date : 2024-04-14 Alex I. Wiesman, Jonathan Gallego-Rudolf, Sylvia Villeneuve, Sylvain Baillet, Tony W. Wilson, the PREVENT-AD Research Group
Two neuropathological hallmarks of Alzheimer’s disease (AD) are the accumulation of amyloid-β (Aβ) proteins and alterations in cortical neurophysiological signaling. Despite parallel research indicating disruption of multiple neurotransmitter systems in AD, it has been unclear whether these two phenomena are related to the neurochemical organization of the cortex. We leveraged task-free magnetoencephalography
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Optimal Systolic Blood pressure control after thrombectomy in acute ischemic stroke-a systematic review and meta-analysis medRxiv. Neurol. Pub Date : 2024-04-15 Baikuntha Panigrahi, Rohit Bhatia, Partha Haldar, Risha Sarkar, Imnameren Longkumer
Background and Objectives Although endovascular thrombectomy(EVT) is the standard of care for acute large vessel occlusions(LVO), optimal systolic blood pressure (SBP) control post procedure has remained elusive. Our study aimed to address the question of whether in adult patients of acute ischemic stroke(AIS) who undergo EVT does an intensive SBP control as compared to a less intensive SBP control/conventional
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Leveraging Machine Learning for Enhanced and Interpretable Risk Prediction of Venous Thromboembolism in Acute Ischemic Stroke Care medRxiv. Neurol. Pub Date : 2024-04-13 Youli Jiang, Ao Li, Zhihuan Li, Yanfeng Li, Rong Li, Qingshi Zhao, Guisu Li
Background Stroke is the second leading cause of death globally, with acute ischemic strokes constituting the majority. Venous thromboembolism (VTE) poses a significant risk during the acute phase post-stroke, and early recognition is critical for preventive intervention of VTE.
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Diffusion tractography predicts Deep Brain Stimulation evoked potential amplitude and delay medRxiv. Neurol. Pub Date : 2024-04-13 Sumiko Abe, Jessica Vidmark, Estefania Hernandez-Martin, Maral Kasiri, Rahil Sorouhmojdehi, S. Alireza Seyyed Mousavi, Terence D. Sanger
Objective This study investigated the relationship between DBS evoked potentials (EPs) and diffusion tensor imaging (DTI) in a group of patients with dystonia who underwent DBS treatment. EPs and DTI are both useful methods for studying neural connectivity in the brain but measure different aspects of brain function. EPs provide information on electrical connectivity, while DTI provides information
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Generalizability of Tau and Amyloid Plasma Biomarkers in Alzheimer’s Disease Cohorts of Diverse Genetic Ancestries medRxiv. Neurol. Pub Date : 2024-04-12 Anthony J. Griswold, Farid Rajabli, Tianjie Gu, Jamie Arvizu, Charles G. Golightly, Patrice L. Whitehead, Kara L. Hamilton-Nelson, Larry D. Adams, Jose Javier Sanchez, Pedro R. Mena, Takiyah D. Starks, Maryenela Illanes-Manrique, Concepcion Silva, William S. Bush, Michael L. Cuccaro, Jeffery M. Vance, Mario R Cornejo-Olivas, Briseida E. Feliciano-Astacio, Goldie S. Byrd, Gary W. Beecham, Jonathan L
Introduction Plasma phosphorylated threonine-181 of Tau and amyloid beta are biomarkers for differential diagnosis and preclinical detection of Alzheimer disease (AD). Given differences in AD risk across diverse populations, generalizability of existing biomarker data is not assured.
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Muscle MRI quantifies disease progression in Amyotrophic Lateral Sclerosis medRxiv. Neurol. Pub Date : 2024-04-12 Uros Klickovic, Luca Zampedri, Nick Zafeiropoulos, Oliver J Ziff, Christopher DJ Sinclair, Stephen J Wastling, Magda Dudziec, Jodie Allen, Karin Trimmel, Robin S Howard, Andrea Malaspina, Nikhil Sharma, Katie CL Sidle, Sachit Shah, Christian Nasel, Tarek A Yousry, Linda Greensmith, Jasper M Morrow, John S Thornton, Pietro Fratta
Importance Quantitative, sensitive and operator-independent biomarkers of disease progression are needed to minimize the size, duration, and cost of clinical trials in amyotrophic lateral sclerosis (ALS) to allow a more effective investigation of promising therapeutic agents.
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CSF proteomic analysis of semorinemab Ph2 trials in prodromal-to-mild (Tauriel) and mild-to-moderate (Lauriet) Alzheimer’s disease identifies distinct trial cell-type specific proteomic signatures medRxiv. Neurol. Pub Date : 2024-04-12 Alyaa M. Abdel-Haleem, Ellen Casavant, Balazs Toth, Edmond Teng, Cecilia Monteiro, Nikhil J. Pandya, Casper C. Hoogenraad, Brad A. Friedman, Felix L. Yeh, Veronica G. Anania, Gloriia Novikova
Targeting of tau pathology has long been proposed as a potential therapeutic strategy for Alzheimer’s disease (AD). Semorinemab is a humanized IgG4 monoclonal antibody that binds to all known isoforms of full-length tau with high affinity and specificity. Semorinemab’s safety and efficacy have been studied in two Phase 2 randomized, double-blind, placebo-controlled, parallel-group clinical trials:
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Interrater agreement of annotations of epileptiform discharges and its impact on deep learning – A pilot study medRxiv. Neurol. Pub Date : 2024-04-12 Mats Svantesson, Anders Eklund, Magnus Thordstein
Background Expert interrater agreement for epileptiform discharges can be moderate. This reasonably will affect the performance when developing classifiers based on annotations performed by experts. In addition, evaluation of classifier performance will be difficult since the ground truth will have a variability. In this pilot study, these aspects were investigated to evaluate the feasibility of conducting
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Social-semantic knowledge in frontotemporal dementia and after anterior temporal lobe resection medRxiv. Neurol. Pub Date : 2024-04-12 Matthew A. Rouse, Ajay D. Halai, Siddharth Ramanan, Timothy T. Rogers, Peter Garrard, Karalyn Patterson, James B. Rowe, Matthew A. Lambon Ralph
Degraded semantic memory is a prominent feature of frontotemporal dementia (FTD). It is classically associated with semantic dementia and anterior temporal lobe (ATL) atrophy, but semantic knowledge can also be compromised in behavioural-variant FTD (bvFTD). Motivated by understanding behavioural change in FTD, recent research has focused selectively on social-semantic knowledge, with proposals that
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The effect of Alzheimer’s disease and its progression on pyramidal cell gain and connectivity medRxiv. Neurol. Pub Date : 2024-04-12 Juliette H Lanskey, Amirhossein Jafarian, Melek Karadag, Ece Kocagoncu, Rebecca Williams, Pranay Yadav, Andrew J Quinn, Jemma Pitt, Tony Thayanandan, Stephen Lowe, Michael Perkinton, Maarten Timmers, Vanessa Raymont, Krish D Singh, Mark Woolrich, Anna C Nobre, Richard N Henson, James B Rowe, the NTAD study group
Alzheimer’s disease affects our cognitive neurophysiology by loss of neurones, synapses and neurotransmitters. An improved mechanistic understanding of the human disease will facilitate new treatments. To this end, biophysically-informed dynamic causal models can support inferences around laminar and cell-specific disease effects from human non-invasive imaging. Based on pre-clinical models and effects
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Enhancing Cognitive Performance Prediction through White Matter Hyperintensity Connectivity Assessment: A Multicenter Lesion Network Mapping Analysis of 3,485 Memory Clinic Patients medRxiv. Neurol. Pub Date : 2024-04-11 Marvin Petersen, Mirthe Coenen, Charles DeCarli, Alberto De Luca, Ewoud van der Lelij, Alzheimer’s Disease Neuroimaging Initiative, Frederik Barkhof, Thomas Benke, Christopher P. L. H. Chen, Peter Dal-Bianco, Anna Dewenter, Marco Duering, Christian Enzinger, Michael Ewers, Lieza G. Exalto, Evan F. Fletcher, Nicolai Franzmeier, Saima Hilal, Edith Hofer, Huiberdina L. Koek, Andrea B. Maier, Pauline M
Introduction White matter hyperintensities of presumed vascular origin (WMH) are associated with cognitive impairment and are a key imaging marker in evaluating cognitive health. However, WMH volume alone does not fully account for the extent of cognitive deficits and the mechanisms linking WMH to these deficits remain unclear. We propose that lesion network mapping (LNM), enables to infer if brain
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An accurate and rapidly calibrating speech neuroprosthesis medRxiv. Neurol. Pub Date : 2024-04-10 Nicholas S. Card, Maitreyee Wairagkar, Carrina Iacobacci, Xianda Hou, Tyler Singer-Clark, Francis R. Willett, Erin M. Kunz, Chaofei Fan, Maryam Vahdati Nia, Darrel R. Deo, Aparna Srinivasan, Eun Young Choi, Matthew F. Glasser, Leigh R. Hochberg, Jaimie M. Henderson, Kiarash Shahlaie, David M. Brandman, Sergey D. Stavisky
Brain-computer interfaces can enable rapid, intuitive communication for people with paralysis by transforming the cortical activity associated with attempted speech into text on a computer screen. Despite recent advances, communication with brain-computer interfaces has been restricted by extensive training data requirements and inaccurate word output. A man in his 40’s with ALS with tetraparesis and
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Disability patterns in multiple sclerosis: a meta-analysis on PIRA and RAW in the real world context medRxiv. Neurol. Pub Date : 2024-04-10 Luca Prosperini, Serena Ruggieri, Shalom Haggiag, Carla Tortorella, Claudio Gasperini
Background The confirmed disability accrual (CDA) due to multiple sclerosis (MS) is driven by two factors: relapse-associated worsening (RAW) and progression independent of relapse activity (PIRA). However, accurate estimations of these phenomena in the real-world setting are lacking. This study aims at summarizing current evidence on RAW and PIRA, including associated factors, through a quantitative
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Characteristic Fetal Brain MRI Abnormalities in Pyruvate Dehydrogenase Complex Deficiency medRxiv. Neurol. Pub Date : 2024-04-10 Olivier Fortin, Kelsey Christoffel, Abdullah Shoaib, Charu Venkatesan, Kate Cilli, Jason W. Schroeder, Cesar Alves, Rebecca D. Ganetzky, Jamie L. Fraser
Pyruvate dehydrogenase complex deficiency (PDCD) is a disorder of mitochondrial metabolism that is caused by pathogenic variants in multiple genes, including PDHA1. Typical neonatal brain imaging findings in PDCD have been described, with a focus on malformative features and chronic encephaloclastic changes. However, fetal brain MRI imaging in confirmed PDCD has not been comprehensively described.
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Apraxia profiles predict general cognitive deficits in patients with biomarker-verified Alzheimer’s pathology medRxiv. Neurol. Pub Date : 2024-04-10 Peter H. Weiss, Claudia C. Schmidt, Michella Barddakan, Elena Jaeger, Nils Richter, Gérard N. Bischof, Kathrin Giehl, Özgür A. Onur, Frank Jessen, Gereon R. Fink, Alexander Drzezga
Background Apraxia represents a core feature of Alzheimer’s disease, a neurodegenerative disorder associated with increased β-amyloid plaques and tau deposition. However, descriptions of apraxic deficits in AD patients are still scarce. Here, we comprehensively investigate apraxia profiles and their impact on general cognitive deficits in patients with biomarker-verified Alzheimer’s pathology.
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Cortical Tau Aggregation Patterns associated with Apraxia in Alzheimer‘s Disease medRxiv. Neurol. Pub Date : 2024-04-10 Gérard N. Bischof, Elena Jaeger, Kathrin Giehl, Frank Jessen, Oezguer A. Onur, Sid O’Bryant, Esra Kara, Peter H. Weiss, Alexander Drzezga
Objectives Apraxia is a core feature of Alzheimer’s disease, but the pathomechanism of this characteristic symptom is not well understood. Here, we systematically investigated apraxia profiles in a well-defined group of patients with Alzheimer’s disease (AD; N=32) who additionally underwent PET imaging with the second-generation tau PET tracer [18F]PI-2620. We hypothesized that specific patterns of
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Association of caffeine consumption with memory deficits and cerebrospinal fluid biomarkers in Mild Cognitive Impairment and Alzheimer’s Disease: a BALTAZAR cohort study medRxiv. Neurol. Pub Date : 2024-04-10 David Blum, Emeline Cailliau, Hélène Béhal, Jean-Sébastien Vidal, Constance Delaby, Luc Buée, Bernadette Allinquant, Audrey Gabelle, Stéphanie Bombois, Sylvain Lehmann, Susanna Schraen-Maschke, Olivier Hanon, the BALTAZAR study group
INTRODUCTION We investigated the link between habitual caffeine intake with memory deficits and CSF AD biomarkers in Mild cognitive impairment (MCI) and Alzheimer’s Disease (AD) patients.
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Impaired language in Alzheimer’s disease: A comparison between English and Persian implicates content-word frequency rather than the noun-verb distinction medRxiv. Neurol. Pub Date : 2024-04-10 Mahya Sanati, Sabereh Bayat, Mehrdad Mohammad Panahi, Amirhossein Khodadadi, Sahar Rezaee, Mahdieh Ghasimi, Sara Besharat, Zahra Mahboubi Fooladi, Mostafa Almasi Dooghaee, Morteza Sanei Taheri, Bradford C Dickerson, Adele Goldberg, Neguine Rezaii
This study challenges the conventional psycholinguistic view that the distinction between nouns and verbs is pivotal in understanding language impairments in neurological disorders. Traditional views link frontal brain region damage with verb processing deficits and posterior temporoparietal damage with noun difficulties. However, this perspective is contested by findings from patients with Alzheimer’s
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Post-stroke Epilepsy and its Association with Stroke Location – Systematic review and Meta-analysis medRxiv. Neurol. Pub Date : 2024-04-10 Sihyeong Park, Yasar T. Esengul, Khaled Gharaibeh, Sidra Saleem, Ajaz Sheikh
Objective There have been several meta-analytic studies that investigated potential risk factors for post-stroke epilepsy (PSE)1,2. Cortical location is known to be associated with increased risk of PSE. However, relationship between the involvement of specific lobe with stroke and PSE has not been evaluated in a meta-analysis due to unavailability of relevant data. To the best of our knowledge, this
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Clemastine fumarate accelerates accumulation of disability in progressive multiple sclerosis by enhancing pyroptosis medRxiv. Neurol. Pub Date : 2024-04-10 Joanna Kocot, Peter Kosa, Shinji Ashida, Nicolette Pirjanian, Raphaela Goldbach-Mansky, Karin Peterson, Valentina Fossati, Steven M. Holland, Bibiana Bielekova
Multiple sclerosis (MS) is an immune-mediated demyelinating disease of the central nervous system (CNS). Clemastine fumarate, the over-the-counter antihistamine and muscarinic receptor blocker, has remyelinating potential in MS. A clemastine arm was added to an ongoing platform clinical trial TRAP-MS (NCT03109288) to identify a cerebrospinal fluid (CSF) remyelination signature and to collect safety
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Altered functional connectivity between cortical motor areas and the spinal cord in chronic stroke medRxiv. Neurol. Pub Date : 2024-04-10 Hanna Braaß, Silke Wolf, Jan Feldheim, Ying Chu, Alexandra Tinnermann, Jürgen Finsterbusch, Christian Büchel, Christian Gerloff, Robert Schulz
Systems neuroscience research has significantly contributed to our current understanding of alterations in brain structure and function after ischemic stroke and their importance for recovery processes. Technical limitations have excluded the spinal cord from imaging-based research. Available data are restricted to few microstructural analyses. Functional connectivity data are absent. The present study
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Local Neuronal Sleep after Stroke: The role of cortical bistability in brain reorganization medRxiv. Neurol. Pub Date : 2024-04-09 Caroline Tscherpel, Maike Mustin, Marcello Massimini, Theresa Paul, Ulf Ziemann, Gereon R. Fink, Christian Grefkes
Background Acute cerebral ischemia triggers a number of cellular mechanisms not only leading to excitotoxic cell death but also to enhanced neuroplasticity, facilitating neuronal reorganization and functional recovery.
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Individual contralesional recruitment in the context of structural reserve in early motor reorganization after stroke medRxiv. Neurol. Pub Date : 2024-04-09 Maike Mustin, Lukas Hensel, Gereon R. Fink, Christian Grefkes, Caroline Tscherpel
The concept of structural reserve in stroke reorganization assumes that the functional role of the contralesional hemisphere strongly depends on the brain tissue spared by the lesion in the affected hemisphere. Recent studies, however, have indicated that the impact of the contralesional hemisphere exhibits region-specific variability with concurrently existing maladaptive and supportive influences
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Integrity of dopaminergic terminals in the caudate nucleus is relevant for rest tremor in Parkinson’s disease medRxiv. Neurol. Pub Date : 2024-04-09 Marcelo D. Mendonça, Pedro Ferreira, Francisco Oliveira, Raquel Barbosa, Bruna Meira, Durval Costa, Albino Oliveira-Maia, Joaquim Alves da Silva
Resting tremor (RT) is a Parkinson’s disease (PD) symptom whose relationship with the dopaminergic system remains puzzling. To clarify this relation, we analysed data from 432 subjects from the PPMI (Parkinson’s Progression Markers Initiative) database, a second cohort of 57 PD patients and controls and a third cohort of 86 subjects referred for dopamine transporter single-photon emission computed
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Network localization of pediatric lesion-induced dystonia medRxiv. Neurol. Pub Date : 2024-04-08 Rose Gelineau-Morel, Nomazulu Dlamini, Joel Bruss, Alexander Li Cohen, Amanda Robertson, Dimitrios Alexopoulos, Christopher D. Smyser, Aaron D. Boes
Objective Dystonia is a movement disorder defined by involuntary muscle contractions leading to abnormal postures or twisting and repetitive movements. Classically dystonia has been thought of as a disorder of the basal ganglia, but newer results in idiopathic dystonia and lesion-induced dystonia in adults point to broader motor network dysfunction spanning the basal ganglia, cerebellum, premotor cortex
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Menopausal hormone therapy and the female brain: leveraging neuroimaging and prescription registry data from the UK Biobank cohort medRxiv. Neurol. Pub Date : 2024-04-08 Claudia Barth, Liisa A.M. Galea, Emily G. Jacobs, Bonnie H. Lee, Lars T. Westlye, Ann-Marie G. de Lange
Background and Objectives Menopausal hormone therapy (MHT) is generally thought to be neuroprotective, yet results have been inconsistent. Here, we present a comprehensive study of MHT use and brain characteristics in middle- to older aged females from the UK Biobank, assessing detailed MHT data, APOE ε4 genotype, and tissue-specific gray (GM) and white matter (WM) brain age gap (BAG), as well as hippocampal
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Stroke-induced slow oscillations in dynamic brain organization medRxiv. Neurol. Pub Date : 2024-04-08 Caroline Tscherpel, Maike Mustin, Nils Rosjat, Ulf Ziemann, Gereon R. Fink, Silvia Daun, Christian Grefkes
A focal ischemic lesion is thought to alter neuronal activity beyond the area of structural damage and thereby interfere with the whole network architecture.
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Apraxic imitation deficits in Alzheimer’s disease are associated with altered dynamic connectivity medRxiv. Neurol. Pub Date : 2024-04-06 Taylan D. Kuzu, Elena Jaeger, Anna K. Bonkhoff, Veronika Wunderle, Gérard N. Bischof, Kathrin Giehl, Maximilian H. T. Schmieschek, Özgür A. Onur, Frank Jessen, Gereon R. Fink, Alexander Drzezga, Peter H. Weiss
Apraxia is a common symptom in individuals with Alzheimer’s disease (AD). However, the neural mechanisms underlying apraxic deficits in AD remain elusive. Therefore, the current study focuses on the association between altered functional connectivity and apraxia in individuals with AD examining the hypothesis that apraxic deficits in AD result from dysfunction in praxis-related networks.
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Intensive Versus Conservative Blood Pressure Lowering after Endovascular Therapy in Stroke: a meta-analysis of randomized controlled trials medRxiv. Neurol. Pub Date : 2024-04-06 Ahmed Naji Mansoor, Vatsalya Choudhary, Zain Mohammad Nasser, Muskan Jain, Dhruvikumari Dayanand Sharma, Mateo Jaramillo Villegas, Sujaritha Janarthanam, Muhammad Ayyan, Simran Ravindra Nimal, Huzaifa Ahmad Cheema, Muhammad Ehsan, Muhammad Aemaz Ur Rehman, Sourbha S. Dani
Background The optimum systolic blood pressure after endovascular thrombectomy for acute ischemic stroke is uncertain. We aimed to perform an updated meta-analysis of randomized controlled trials to evaluate the safety and efficacy of more intensive blood pressure management as compared to less intensive blood pressure management.
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Age- and sex-related changes in motor functions: A Comprehensive Assessment and Component Analysis medRxiv. Neurol. Pub Date : 2024-04-05 Veronika Wunderle, Taylan D. Kuzu, Caroline Tscherpel, Gereon R. Fink, Christian Grefkes, Peter H. Weiss
Age-related motor impairments often cause caregiver dependency or even hospitalization. However, comprehensive investigations of the different motor abilities and the changes thereof across the adult lifespan remain sparse.
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Gene specific effects on brain volume and cognition of TMEM106B in frontotemporal lobar degeneration medRxiv. Neurol. Pub Date : 2024-04-05 Marijne Vandebergh, Eliana Marisa Ramos, Nick Corriveau-Lecavalier, Vijay K Ramanan, John Kornak, Carly Mester, Tyler Kolander, Danielle Brushaber, Adam M Staffaroni, Daniel Geschwind, Amy Wolf, Kejal Kantarci, Tania F Gendron, Leonard Petrucelli, Marleen Van den Broeck, Sarah Wynants, Matthew C Baker, Sergi Borrego – Écija, Brian Appleby, Sami Barmada, Andrea Bozoki, David Clark, R Ryan Darby, Bradford
Background and Objectives TMEM106B has been proposed as a modifier of disease risk in FTLD-TDP, particularly in GRN mutation carriers. Furthermore, TMEM106B has been investigated as a disease modifier in the context of healthy aging and across multiple neurodegenerative diseases. The objective of this study is to evaluate and compare the effect of TMEM106B on gray matter volume and cognition in each
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Modulation of subcortical activity along the migraine cycle during cognitive executive load medRxiv. Neurol. Pub Date : 2024-04-03 Amparo Ruiz-Tagle, Gina Caetano, Ana Fouto, Inês Esteves, Inês Cabaço, Nuno Da Silva, Pedro Vilela, Pedro Nascimento Alves, Isabel Pavão Martins, Raquel Gil Gouveia, Patrícia Figueiredo
Objective To analyze cognition and brain activation during an executive task in migraine patients studied in the different phases of the migraine cycle, compared with healthy participants.
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Reward enhances motor adaptation learning in acute stroke patients medRxiv. Neurol. Pub Date : 2024-04-03 Theresa Paul, Valerie M. Wiemer, Jonas Günther, Finn M. Lehnberg, Scott T. Grafton, Gereon R. Fink, Lukas J. Volz
The majority of motor recovery occurs within the first weeks after stroke and has been hypothesized to rely on similar mechanisms as motor learning. However, it remains unknown whether acute stroke patients are capable of error-based motor adaptation learning and, if so, whether such learning may be enhanced by reinforcement feedback. Here, we show for the first time that acute stroke patients exhibit
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A platform for brain network sensing and stimulation with quantitative behavioral tracking: Application to limbic circuit epilepsy medRxiv. Neurol. Pub Date : 2024-04-03 Vaclav Kremen, Vladimir Sladky, Filip Mivalt, Nicholas M. Gregg, Irena Balzekas, Victoria Marks, Benjamin H. Brinkmann, Brian Nils Lundstrom, Jie Cui, Erik K. St Louis, Paul Croarkin, Eva C Alden, Julie Fields, Karla Crockett, Jindrich Adolf, Jordan Bilderbeek, Dora Hermes, Steven Messina, Kai J. Miller, Jamie Van Gompel, Timothy Denison, Gregory A. Worrell
Temporal lobe epilepsy is a common neurological disease characterized by recurrent seizures. These seizures often originate from limbic networks and people also experience chronic comorbidities related to memory, mood, and sleep (MMS). Deep brain stimulation targeting the anterior nucleus of the thalamus (ANT-DBS) is a proven therapy, but the optimal stimulation parameters remain unclear. We developed
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Combined detrimental effect of male sex and GBA1 variants on cognitive decline in Parkinson’s Disease medRxiv. Neurol. Pub Date : 2024-04-03 Silvia Paola Caminiti, Micol Avenali, Alice Galli, Rachele Malito, Giada Cuconato, Andrea Pilotto, Alessandro Padovani, Fabio Blandini, Daniela Perani, Cristina Tassorelli, Enza Maria Valente, Parkinson’s Progression Markers Initiative (PPMI)
Background and Objective Heterozygous variants in the glucocerebrosidase gene (GBA1) are the major genetic risk factor for Parkinson’s Disease (PD). GBA-PD has been associated with worse progression and higher risk of cognitive decline. Here we took advantage of the Parkinson’s Progression Markers Initiative (PPMI) to investigate whether sex could interact with GBA1 carrier status in determining the
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Factors influencing survival outcomes in patients with stroke in Zimbabwe: A 12-month longitudinal study medRxiv. Neurol. Pub Date : 2024-04-03 Farayi Kaseke, Lovemore Gwanzura, Cuthbert Musarurwa, Elizabeth Gori, Tawanda Nyengerai, Timothy Kaseke, Aimee Stewart
Background In this longitudinal study, we aimed to determine factors influencing survival outcomes among patients with stroke over a 12-month period. The investigation sought to uncover influential determinants to enhance the precision of prognostic assessments and inform targeted interventions for individuals affected by strokes.
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Laminar multi-contrast fMRI at 7T allows differentiation of neuronal excitation and inhibition underlying positive and negative BOLD responses medRxiv. Neurol. Pub Date : 2024-04-02 Xingfeng Shao, Fanhua Guo, JungHwan Kim, David Ress, Chenyang Zhao, Qinyang Shou, Kay Jann, Danny JJ Wang
A major challenge for human neuroimaging using functional MRI is the differentiation of neuronal excitation and inhibition which may induce positive and negative BOLD responses. Here we present an innovative multi-contrast laminar functional MRI technique that offers comprehensive and quantitative imaging of neurovascular (CBF, CBV, BOLD) and metabolic (CMRO2) responses across cortical layers at 7
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Predictors of positive remodeling in patients with acute ischemia stroke medRxiv. Neurol. Pub Date : 2024-04-02 Gen Li, Di-hao Xu, Jing-wen Xie, Li-ping Ma, Min Shu, Zhi-bin Zeng
Objective This study aimed to delineate the differences in plaques characteristics between positive remodeling (PR) and non-positive remodeling (NPR) in patients with Acute ischemia stroke (AIS), and to assess the associated relative risk factors for PR in intracranial atherosclerosis (ICAS).
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Repetitive subconcussion results in disrupted neural activity independent of concussion history medRxiv. Neurol. Pub Date : 2024-04-01 Kevin Grant Solar, Matthew Ventresca, Rouzbeh Zamyadi, Jing Zhang, Oshin Vartanian, Shawn G Rhind, Benjamin T Dunkley
Concussion is a public health crisis which results in a complex cascade of neurochemical changes in the brain that can have life changing consequences. Subconcussions are considered less serious and were overlooked until recently, but we now realise repetitive subconcussions, such as repetitive head impacts, can lead to serious neurological deficits. Subconcussions are common in contact sports, and
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Interictal waking and sleep electrophysiological properties of the thalamus in focal epilepsies medRxiv. Neurol. Pub Date : 2024-04-01 Tommaso Biagioni, Maria Fratello, Elodie Garnier, Stanislas Lagarde, Romain Carron, Samuel M. Villalon, Isabelle Lambert, Angela Marchi, Julia Makhalova, Agnes Trebuchon, Francesca Bonini, Didier Scavarda, Christian Benar, Fabrice Bartolomei, Francesca Pizzo
Introduction Addressing drug-resistant epilepsy poses a significant clinical hurdle, particularly when conventional resective surgery is not feasible. Deep brain stimulation (DBS) emerges as a potential therapeutic avenue for such cases. To shed light on the thalamo-cortical epileptogenic networks and refine prognostic indicators and treatments, we conducted an exhaustive examination of interictal
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Patients with COVID-19 Infection and Stroke have Higher than Expected Mortality, Regardless of the Primary Presentation medRxiv. Neurol. Pub Date : 2024-03-30 Jintong Liu, Eric Fu, Riley Gillette, Max Wohlauer
Background COVID-19 infection is associated with thrombotic events; however, this phenomenon is poorly understood. Few studies have reported the association between COVID-19 and stroke in the hospital setting.