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FLAMES overlaying anti-N-methyl-D-aspartate receptor encephalitis: a case report and literature review BMC Neurol. (IF 2.6) Pub Date : 2024-04-25 Rimei Zhong, Xiongjin Chen, Feng Liao, Zhijun Lin, Zhijian Zhang, Yusen Chen, Lili Cui
In recent years, simultaneous or sequential occurrence of MOG antibody disease and anti-NMDAR encephalitis in the same patient has been reported with increasing frequency. Scholars refer to the overlapping occurrence of these two disorders as MOG antibody disease and anti-NMDAR encephalitis overlap syndrome (MNOS). Cortical T2-weighted fluid-attenuated inversion recovery (FLAIR) -hyperintense lesions
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Taste disorders and alopecia in myasthenia gravis BMC Neurol. (IF 2.6) Pub Date : 2024-04-25 Akiyuki Uzawa, Shigeaki Suzuki, Satoshi Kuwabara, Hiroyuki Akamine, Yosuke Onishi, Manato Yasuda, Yukiko Ozawa, Naoki Kawaguchi, Tomoya Kubota, Masanori P. Takahashi, Yasushi Suzuki, Genya Watanabe, Takashi Kimura, Takamichi Sugimoto, Makoto Samukawa, Naoya Minami, Masayuki Masuda, Shingo Konno, Yuriko Nagane, Kimiaki Utsugisawa
Non-motor symptoms in myasthenia gravis (MG) are rarely confirmed. Although there are some small cohort studies, a large-systemic survey has not yet been performed. We investigated the incidence and clinical characteristics of patients with MG who had taste disorders and alopecia using data of 1710 patients with MG enrolled in the Japan MG Registry 2021. Among them, 104 (6.1%) out of 1692 patients
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Clinical variables influencing the perception of fatigue in people with multiple sclerosis: a cross-sectional study using FSIQ-RMS BMC Neurol. (IF 2.6) Pub Date : 2024-04-25 Giovanni Sellitto, Ilaria Ruotolo, Antonio Ianniello, Federica Felicetti, Giorgia D’Ambrosi, Anna Berardi, Giovanni Galeoto, Antonella Conte, Carlo Pozzilli
Physical fatigue is one of the most disabling symptoms in people with Multiple Sclerosis (PwMS). Several factors might influence the development of fatigue, such as gender, education, body mass index (BMI), Expanded Disability Status Scale (EDSS), disease duration, working status (Ws), physiotherapy (Ph), and disease-modifying therapies (DMTs). Fatigue Symptoms and Impacts Questionnaire-Relapsing Multiple
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Guillain–Barre syndrome following scrub typhus: a case report and literature review BMC Neurol. (IF 2.6) Pub Date : 2024-04-25 Shijun Hu, Zhichuan lin, Tao Liu, Shixiong Huang, Hui Liang
Scrub typhus is an acute infectious disease caused by Orientia tsutsugamushi. Guillain–Barre syndrome (GBS) is an autoimmune-mediated peripheral neuropathy with a frequent history of prodromal infections, but GBS associated with scrub typhus is very rare. We report a 51-year-old male patient who developed dysarthria and peripheral facial paralysis following the cure of scfrub typhus. CSF examination
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A comparison of clinical features between neurobrucellosis and tuberculous meningitis BMC Neurol. (IF 2.6) Pub Date : 2024-04-25 Yueli Zou, Liqing Wang, Yi Li, Yaning Wu, Junying He, Xiujun Yu
This study aims to compare the clinical manifestations, imaging findings, routine tests, biochemistry indicators and cerebrospinal fluid cytology between neurobrucellosis and tuberculous meningitis. The objective is to evaluate the similarities and differences of these two diseases and improve early diagnosis. A comprehensive evaluation was conducted by comparing clinical data, imaging results, routine
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Alcohol consumption may be a risk factor for cerebrovascular stenosis in acute ischemic stroke and transient ischemic attack BMC Neurol. (IF 2.6) Pub Date : 2024-04-23 Yiti Liu, Shuo Gu, Maoyuan Gou, Xiaoyan Guo
Atherosclerosis are well established risk factors for ischemic stroke, however the association between alcohol consumption and atherosclerosis is controversial. This study aims to explore the potential correlation between alcohol consumption and cerebral stenosis in patients with acute ischemic stroke and transient ischemic attack (TIA). Nine hundreds and eighty-eight patients with first acute ischemic
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Contrast extravasation mimicking intracerebral and intraventricular hemorrhage after intravenous thrombolytic treatment of ischemic stroke: a case report BMC Neurol. (IF 2.6) Pub Date : 2024-04-19 Jiuning Tang, Xinhai Zhang, Jinhui Yu, Zhi Liu, Huaqiang Ding
Although contrast extravasation on follow-up head computed tomography (CT) is frequently visualized after endovascular treatment, this phenomenon is rare after intravenous thrombolytic treatment in patients with acute ischemic stroke (AIS). Here, we report a case of contrast extravasation mimicking intracerebral hemorrhage (ICH) with intraventricular extension after intravenous thrombolytic treatment
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Applicability and clinical utility of the German rivermead post-concussion symptoms questionnaire in proxies of children after traumatic brain injury: an instrument validation study BMC Neurol. (IF 2.6) Pub Date : 2024-04-19 Fabian Bockhop, Sven Greving, Marina Zeldovich, Ugne Krenz, Katrin Cunitz, Dagmar Timmermann, Matthias Kieslich, Nada Andelic, Anna Buchheim, Inga K. Koerte, Maike Roediger, Knut Brockmann, Michaela V. Bonfert, Steffen Berweck, Michael Lendt, Michael Staebler, Nicole von Steinbuechel
The German Rivermead Post-Concussion Symptoms Questionnaire (RPQ) can be used to assess post-concussion symptoms (PCS) after traumatic brain injury (TBI) in adults, adolescents, and children. In this study, we examined the psychometric properties of the German RPQ proxy version (N = 146) for children (8—12 years) after TBI at the item, total and scale score level. Construct validity was analyzed using
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Computer-aided cognitive training combined with tDCS can improve post-stroke cognitive impairment and cerebral vasomotor function: a randomized controlled trial BMC Neurol. (IF 2.6) Pub Date : 2024-04-19 Yin Chen, Ziqi Zhao, Jiapeng Huang, Tingting Wang, Yun Qu
Post-stroke cognitive impairment (PSCI) is the focus and difficulty of poststroke rehabilitation intervention with an incidence of up to 61%, which may be related to the deterioration of cerebrovascular function. Computer-aided cognitive training (CACT) can improve cognitive function through scientific training targeting activated brain regions, becoming a popular training method in recent years. Transcranial
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Study protocol: exercise training for treating major depressive disorder in multiple sclerosis BMC Neurol. (IF 2.6) Pub Date : 2024-04-17 Robert W. Motl, Charles H. Bombardier, Jennifer Duffecy, Brooks Hibner, Alison Wathen, Michael Carrithers, Gary Cutter
Major depressive disorder (MDD) is prevalent, yet sub-optimally treated among persons with multiple sclerosis (MS). We propose that exercise training may be a promising approach for treating depression in persons with MS who have MDD. Our primary hypothesis predicts a reduction in depression severity immediately after an exercise training intervention compared with minimal change in an attention control
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Identifying high-risk neurological phenotypes in adult-onset classic monogenic autoinflammatory diseases: when should neurologists consider testing? BMC Neurol. (IF 2.6) Pub Date : 2024-04-17 Guilherme Diogo Silva, João Vitor Mahler, Sérgio Roberto Pereira da Silva Junior, Leonardo Oliveira Mendonça, Pedro Lucas Grangeiro de Sá Barreto Lima, Paulo Ribeiro Nóbrega, Fernando Kok, Fernando Freua
Monogenic autoinflammatory disorders result in a diverse range of neurological symptoms in adults, often leading to diagnostic delays. Despite the significance of early detection for effective treatment, the neurological manifestations of these disorders remain inadequately recognized. We conducted a systematic review searching Pubmed, Embase and Scopus for case reports and case series related to neurological
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Beyond gait speed: exploring the added value of Inertial Measurement Unit-based measurements of gait in the estimation of the walking ability in daily life BMC Neurol. (IF 2.6) Pub Date : 2024-04-17 R. A. W. Felius, N. C. Wouda, M. Geerars, S. M. Bruijn, J. H. van Dieën, M. Punt
Gait speed is often used to estimate the walking ability in daily life in people after stroke. While measuring gait with inertial measurement units (IMUs) during clinical assessment yields additional information, it remains unclear if this information can improve the estimation of the walking ability in daily life beyond gait speed. We evaluated the additive value of IMU-based gait features over a
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Cerebral blood flow changes in maintenance hemodialysis patients with restless legs syndrome and their clinical significance:a cross-sectional case-control study BMC Neurol. (IF 2.6) Pub Date : 2024-04-16 Chen Li, Wei Sun, Linfang Xu, Cheng Chen, Li Fang, Yushang Tang, Qiaoyang Zhang, Haifeng Shi, Tongqiang Liu
Restless legs syndrome (RLS) stands as a prevalent neurological complication within maintenance hemodialysis (MHD) patients. However, the alterations in cerebral blood flow (CBF) among MHD-RLS patients remain uncharted. Through the utilization of the arterial spin labeling (ASL) technique, we evaluated the fluctuations in CBF within distinct brain regions and analyzed the risk factors for the development
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Development of a smartphone screening test for preclinical Alzheimer’s disease and validation across the dementia continuum BMC Neurol. (IF 2.6) Pub Date : 2024-04-16 Jane Alty, Lynette R. Goldberg, Eddy Roccati, Katherine Lawler, Quan Bai, Guan Huang, Aidan D Bindoff, Renjie Li, Xinyi Wang, Rebecca J. St George, Kaylee Rudd, Larissa Bartlett, Jessica M. Collins, Mimieveshiofuo Aiyede, Nadeeshani Fernando, Anju Bhagwat, Julia Giffard, Katharine Salmon, Scott McDonald, Anna E. King, James C. Vickers
Dementia prevalence is predicted to triple to 152 million globally by 2050. Alzheimer’s disease (AD) constitutes 70% of cases. There is an urgent need to identify individuals with preclinical AD, a 10–20-year period of progressive brain pathology without noticeable cognitive symptoms, for targeted risk reduction. Current tests of AD pathology are either too invasive, specialised or expensive for population-level
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Calcitonin gene-related peptide: a possible biomarker in migraine patients with patent foramen ovale BMC Neurol. (IF 2.6) Pub Date : 2024-04-16 Chaojie Li, Yu Yu, Ningning Li, Ya-Na Yin, Lianjun Zhang, Kehang Xie, Donghui Huang
Serum CGRP has been found to increase during migraine attack. However, whether CGRP can identify MA with PFO subtypes in MA remains unknown. This study aimed to investigate the differential expression of calcitonin gene-related peptide (CGRP) between migraine (MA) patients with and without patent foramen ovale (PFO), and to evaluate the predictive value of CGRP for MA with PFO. A total of 153 patients
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Designing and validating of a questionnaire measuring perceived self-care ability (PSCA) in chronic stroke patients at home BMC Neurol. (IF 2.6) Pub Date : 2024-04-15 Nasrin Jafari-golestan, Asghar Dalvandi, Mohammadali Hosseini, Masoud Fallahi-Khoshknab, Abbas Ebadi, Mahdi Rahgozar, Sidani Souraya
Patients with a stroke often cannot care for themselves after hospital discharge. Assessment of their self-care ability is the first step in planning post-discharge home care. This study aimed to design and validate a measure of perceived self-care ability (PSCA) in stroke patients. A sequential-exploratory mixed method was conducted in Tehran, Iran, in 2020–2021. The qualitative phase involved in-depth
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Multi-organ involvement caused by Scedosporium apiospermum infection after near drowning: a case report and literature review BMC Neurol. (IF 2.6) Pub Date : 2024-04-15 Yao Yao, Qian Xu, Wenwen Liang, Suqiong Ji, Mohammadreza Kosari, Shabei Xu, Zhou Zhu, Zhijuan Mao
Scedosporium apiospermum (S. apiospermum) is a rare fungal pathogen that causes disseminated infections. It rarely affects immunocompetent individuals and has a poor prognosis. A 37-year-old woman presented with multiple lesions in the lungs, brain, and eyes, shortly after near drowning in a car accident. The primary symptoms were chest tightness, limb weakness, headache, and poor vision in the left
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Childhood and adolescence factors and multiple sclerosis: results from the German National Cohort (NAKO) BMC Neurol. (IF 2.6) Pub Date : 2024-04-13 Anja Holz, Nadia Obi, Wolfgang Ahrens, Klaus Berger, Barbara Bohn, Hermann Brenner, Beate Fischer, Julia Fricke, Amand Führer, Sylvia Gastell, Karin Halina Greiser, Volker Harth, Jana-Kristin Heise, Bernd Holleczek, Thomas Keil, Carolina J. Klett-Tammen, Michael Leitzmann, Wolfgang Lieb, Claudia Meinke-Franze, Karin B. Michels, Rafael Mikolajczyk, Katharina Nimptsch, Annette Peters, Tobias Pischon
Multiple Sclerosis (MS) represents the most common inflammatory neurological disease causing disability in early adulthood. Childhood and adolescence factors might be of relevance in the development of MS. We aimed to investigate the association between various factors (e.g., prematurity, breastfeeding, daycare attendance, weight history) and MS risk. Data from the baseline assessment of the German
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Red blood cell distribution width as a predictor of mortality and poor functional outcome after acute ischemic stroke: a meta-analysis and meta-regression BMC Neurol. (IF 2.6) Pub Date : 2024-04-12 Huiqin Shen, Lihong Shen
This study aimed to review evidence on the ability of red cell distribution width (RDW) to predict mortality and poor functional outcomes after acute ischemic stroke (AIS). Databases of PubMed, CENTRAL, Scopus, Embase, and Web of Science were searched online from inception to 25th Jul 2023 for all studies reporting the association between RDW and outcomes as adjusted ratios. A random-effects meta-analysis
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Uraemic brainstem encephalopathy mimicking ocular myasthenia: a case report BMC Neurol. (IF 2.6) Pub Date : 2024-04-12 Pramith Ruwanpathirana, Thashi Chang
Uraemia causes a generalised encephalopathy as its most common neurological complication. Isolated brainstem uraemic encephalopathy is rare. We report a case of fatigable ptosis and complex ophthalmoplegia in brainstem uraemic encephalopathy. A 22-year-old Sri Lankan man with end stage renal failure presented with acute onset diplopia and drooping of eyelids progressively worsening over one week. The
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Large variations in atrial fibrillation screening practice after ischemic stroke and transient ischemic attack in Sweden: a survey study BMC Neurol. (IF 2.6) Pub Date : 2024-04-11 Kajsa Strååt, Eva Isaksson, Ann Charlotte Laska, Elisabeth Rooth, Emma Svennberg, Signild Åsberg, Per Wester, Johan Engdahl
Atrial fibrillation (AF) screening after ischemic stroke or transient ischemic attack (TIA) is given high priority in clinical guidelines. However, patient selection, electrocardiogram (ECG) modality and screening duration remains undecided and current recommendations vary. The aim of this study was to investigate the clinical practice of AF screening after ischemic stroke or TIA at Swedish stroke
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A novel NODAL variant in a young embolic stroke patient with visceral heterotaxy BMC Neurol. (IF 2.6) Pub Date : 2024-04-11 Kei Kaburagi, Yuta Hagiwara, Keiji Tachikawa, Noriko Miyake, Hisanao Akiyama, Yosuke Kawai, Yosuke Omae, Katsushi Tokunaga, Yoshihisa Yamano, Takahiro Shimizu, Satomi Mitsuhashi
Ischemic stroke in young adults can be caused by a variety of etiologies including the monogenic disorders. Visceral heterotaxy is a condition caused by abnormal left–right determinations during embryonic development. We aimed to determine the cause of a young ischemic stroke patient with visceral heterotaxy. We performed neurological, radiological, and genetic evaluations in a 17-year-old male patient
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Adult vasovagal syncope with abdominal pain diagnosed by head-up tilt combined with transcranial doppler: a preliminary study BMC Neurol. (IF 2.6) Pub Date : 2024-04-10 Jingyi Wang, Hua Li, Xuming Huang, Huoyou Hu, Baorong Lian, Daxue Zhang, Jiarui Wu, Liming Cao
Syncope is a common condition that increases the risk of injury and reduces the quality of life. Abdominal pain as a precursor to vasovagal syncope (VVS) in adults is rarely reported and is often misdiagnosed.. We present three adult patients with VVS and presyncopal abdominal pain diagnosed by synchronous multimodal detection (transcranial Doppler [TCD] with head-up tilt [HUT]) and discuss the relevant
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Correction: Photobiomodulation combination therapy as a new insight in neurological disorders: a comprehensive systematic review BMC Neurol. (IF 2.6) Pub Date : 2024-04-10 Narmin Farazi, Hanieh Salehi-Pourmehr, Fereshteh Farajdokht, Javad Mahmoudi, Saeed Sadigh-Eteghad
Correction: BMC Neurol 24, 101 (2024) https://doi.org/10.1186/s12883-024-03593-4 Following publication of the original article [1], the authors reported that the conclusion section was missing in the published article. The missing conclusion is provided below. Conclusion. This systematic review clearly demonstrates the therapeutic role of PBM combined therapies, as well as their potential to improve
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Onset of Alzheimer disease in apolipoprotein ɛ4 carriers is earlier in butyrylcholinesterase K variant carriers BMC Neurol. (IF 2.6) Pub Date : 2024-04-09 Roger M. Lane, Taher Darreh-Shori, Candice Junge, Dan Li, Qingqing Yang, Amanda L. Edwards, Danielle L. Graham, Katrina Moore, Catherine J. Mummery
The authors sought to examine the impact of the K-variant of butyrylcholinesterase (BCHE-K) carrier status on age-at-diagnosis of Alzheimer disease (AD) in APOE4 carriers. Patients aged 50–74 years with cerebrospinal fluid (CSF) biomarker-confirmed AD, were recruited to clinical trial (NCT03186989 since June 14, 2017). Baseline demographics, disease characteristics, and biomarkers were evaluated in
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Improving emotion perception in cochlear implant users: insights from machine learning analysis of EEG signals BMC Neurol. (IF 2.6) Pub Date : 2024-04-08 Sebastien Paquette, Samir Gouin, Alexandre Lehmann
Although cochlear implants can restore auditory inputs to deafferented auditory cortices, the quality of the sound signal transmitted to the brain is severely degraded, limiting functional outcomes in terms of speech perception and emotion perception. The latter deficit negatively impacts cochlear implant users’ social integration and quality of life; however, emotion perception is not currently part
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Feasibility of a novel eHealth intervention for Parkinson’s disease targeting motor-cognitive function in the home BMC Neurol. (IF 2.6) Pub Date : 2024-04-05 Jenny Sedhed, Hanna Johansson, Nina Andersson, Elisabet Åkesson, Elke Kalbe, Erika Franzén, Breiffni Leavy
Parkinson’s disease (PD) drastically affects motor and cognitive function, but evidence shows that motor-cognitive training improves disease symptoms. Motor-cognitive training in the home is scarcely investigated and eHealth methods can provide continual support for PD self-management. Feasibility testing is however required. To assess the feasibility (i) Recruitment capability (ii) Acceptability and
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Fabry disease in W162C mutation: a case report of two patients and a review of literature BMC Neurol. (IF 2.6) Pub Date : 2024-04-05 Alessandro Furia, Raffaello Ditaranto, Elena Biagini, Vanda Parisi, Alex Incensi, Sara Parisini, Rocco Liguori, Vincenzo Donadio
Fabry disease is a multisystemic disorder characterized by deposition of globotriaosylceramide (Gb3) and its deacylated form in multiple organs, sometimes localized in specific systems such as the nervous or cardiovascular system. As disease-modifying therapies are now available, early diagnosis is paramount to improving life quality and clinical outcomes. Despite the widespread use of non-invasive
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Streptococcus intermedius causing primary bacterial ventriculitis in a patient with severe periodontitis - a case report BMC Neurol. (IF 2.6) Pub Date : 2024-04-05 Satu Allonen, Janne Aittoniemi, Matti Vuorialho, Lassi Närhi, Kari Panula, Risto Vuento, Jari Honkaniemi
Streptococcus intermedius is a member of the S. anginosus group and is part of the normal oral microbiota. It can cause pyogenic infections in various organs, primarily in the head and neck area, including brain abscesses and meningitis. However, ventriculitis due to periodontitis has not been reported previously. A 64-year-old male was admitted to the hospital with a headache, fever and later imbalance
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Evaluating the effect of rapamycin treatment in Alzheimer’s disease and aging using in vivo imaging: the ERAP phase IIa clinical study protocol BMC Neurol. (IF 2.6) Pub Date : 2024-04-04 Jonas E. Svensson, Martin Bolin, Daniel Thor, Pete A. Williams, Rune Brautaset, Marcus Carlsson, Peder Sörensson, David Marlevi, Rubens Spin-Neto, Monika Probst, Göran Hagman, Anton Forsberg Morén, Miia Kivipelto, Pontus Plavén-Sigray
Rapamycin is an inhibitor of the mechanistic target of rapamycin (mTOR) protein kinase, and preclinical data demonstrate that it is a promising candidate for a general gero- and neuroprotective treatment in humans. Results from mouse models of Alzheimer’s disease have shown beneficial effects of rapamycin, including preventing or reversing cognitive deficits, reducing amyloid oligomers and tauopathies
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Exploring vascular contributions to cognitive impairment and dementia (ENIGMA): protocol for a prospective observational study BMC Neurol. (IF 2.6) Pub Date : 2024-04-03 Sigrid Breinholt Vestergaard, Andreas Gammelgaard Damsbo, Niels Lech Pedersen, Katrine Zachariassen, Kim Ryun Drasbek, Leif Østergaard, Grethe Andersen, Rikke Beese Dalby, Janne Kærgård Mortensen
Post-stroke cognitive impairment (PSCI) is common. However, the underlying pathophysiology remains largely unknown. Understanding the role of microvascular changes and finding markers that can predict PSCI, could be a first step towards better screening and management of PSCI. Capillary dysfunction is a pathological feature of cerebral small vessel disease and may play a role in the mechanisms underlying
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Guillain–Barre syndrome of acute motor axonal neuropathy (AMAN) type associated with herpes zoster: a case report BMC Neurol. (IF 2.6) Pub Date : 2024-04-03 Leonard Wanninayake, Dilani Rajapaksha, Narmada Nair, Kamal Gunarathne, Udaya Ranawaka
Guillain Barre syndrome (GBS) following Varicella zoster is a rare presentation and has only been reported in a few cases around the world. Of the reported cases, the type of GBS is not specified in the majority, and where specified is of the acute inflammatory demyelinating polyradiculoneuropathy (AIDP) type. We report a case of acute motor axonal neuropathy (AMAN) type GBS following herpes zoster
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Treatment patterns and persistence on disease modifying therapies for multiple sclerosis and its associated factors BMC Neurol. (IF 2.6) Pub Date : 2024-04-02 Simón Cárdenas-Robledo, Laura Estefanía Arenas-Vargas, Rubén Darío Arenas, Jorge Mario Gaspar-Toro, Ángela María Muñoz-Rosero, Aranza Helena Tafur-Borrero, Daniel Stiven Marín-Medina, Hernan Andrés Acosta-Fajardo, Claudia Guío-Sánchez, Lorena López-Reyes
Effective interventions for Multiple Sclerosis require timely treatment optimization which usually involves switching disease modifying therapies. The patterns of prescription and the reasons for changing treatment in people with MS, especially in low prevalence populations, are unknown. To describe the persistence, reasons of DMT switches and prescription patterns in a cohort of Colombian people with
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Migraine treatment: quo vadis? Real-world data study (2015–2022) in Spain BMC Neurol. (IF 2.6) Pub Date : 2024-04-02 Patricia Pozo-Rosich, Mafalda Carmo, Alejandro Muñiz, Beatriz Armada, Carlota Moya-Alarcón, Julio Pascual
Migraine is a leading cause of disability, estimated to affect one-in-ten people in Spain. This study aimed to describe the management of migraine in Spain and identify improvement areas. Non-interventional, retrospective, cross-sectional cohort study conducted using an electronic medical records database covering visits to public healthcare providers for 3% of the Spanish population. Patients with
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A randomized feasibility trial of medium chain triglyceride-supplemented ketogenic diet in people with Parkinson's disease BMC Neurol. (IF 2.6) Pub Date : 2024-04-01 Alexander H. Choi, Melanie Delgado, Kong Y. Chen, Stephanie T. Chung, Amber Courville, Sara A. Turner, Shanna Yang, Kayla Airaghi, Irene Dustin, Patrick McGurrin, Tianxia Wu, Mark Hallett, Debra J. Ehrlich
A ketogenic diet (KD) may benefit people with neurodegenerative disorders marked by mitochondrial depolarization/insufficiency, including Parkinson’s disease (PD). Evaluate whether a KD supplemented by medium chain triglyceride (MCT-KD) oil is feasible and acceptable for PD patients. Furthermore, we explored the effects of MCT-KD on blood ketone levels, metabolic parameters, levodopa absorption, mobility
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Delays in Multiple Sclerosis diagnosis (DIMES): protocol for a multicentre, observational study of multiple sclerosis diagnostic pathways in the United Kingdom and Republic of Ireland BMC Neurol. (IF 2.6) Pub Date : 2024-03-28 Ashvin Kuri, David E. Henshall, Daoud Chaudhry, Setthasorn Zhi Yang Ooi, Qiqi Zhang, Joela Mathews, Alison Thomson, David Rog, Jeremy Hobart, Ruth Dobson
Multiple sclerosis (MS) is a leading cause of non-traumatic disability in young adults. Accumulating evidence indicates early diagnosis and early treatment improves long-term outcomes. However, the MS diagnostic pathway is increasingly complex, and delays may occur at several stages. Factors causing delays remain understudied. We aim to quantify the time taken for MS to be diagnosed, and characterise
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Early ambulation protocol after diagnostic transfemoral cerebral angiography: an evidence-based practice project BMC Neurol. (IF 2.6) Pub Date : 2024-03-25 Hao Liang, Richun Ye, Nana Song, Canhui Zhu, Miaolong Xu, Qiaoyu Ye, Lin Wei, Jiehan Chen
No uniform consensus has been achieved regarding the ambulation protocol after transfemoral cerebral angiography (TFA). Until now, in most hospitals patients are prescribed 8-12 h strict immobilization along with bed rest in the supine position after TFA in China, which causes great discomfort to patients. To evaluate the effect of an evidence-based early ambulation protocol on the prevention of vascular
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A systematic review of high impact CpG sites and regions for MGMT methylation in glioblastoma [A systematic review of MGMT methylation in GBM] BMC Neurol. (IF 2.6) Pub Date : 2024-03-23 David Gibson, Anh Huan Vo, Hannah Lambing, Prithanjan Bhattacharya, Peggy Tahir, Farid F. Chehab, Nicholas Butowski
MGMT (O 6 -methylguanine-DNA methyltransferase) promoter methylation is a commonly assessed prognostic marker in glioblastoma (GBM). Epigenetic silencing of the MGMT gene by promoter methylation is associated with greater overall and progression free survival with alkylating agent regimens. To date, there is marked heterogeneity in how MGMT promoter methylation is tested and which CpG sites are interrogated
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Partial facial paralysis induced by sialolithiasis of the parotid gland: a case report BMC Neurol. (IF 2.6) Pub Date : 2024-03-22 Abhinav Suri, Stephen Avila, Christina Tan, Huda Alalami, Jennifer Harris
Facial paralysis due to parotid sialolithiasis-induced parotitis is a unusual clinical phenomenon that has not been reported in prior literature. This scenario can present a diagnostic challenge due to its rarity and complex symptomatology, particularly if a patient has other potential contributing factors such as facial trauma or bilateral forehead botox injections as in this patient. This case report
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Photobiomodulation combination therapy as a new insight in neurological disorders: a comprehensive systematic review BMC Neurol. (IF 2.6) Pub Date : 2024-03-19 Narmin Farazi, Hanieh Salehi-Pourmehr, Fereshteh Farajdokht, Javad Mahmoudi, Saeed Sadigh-Eteghad
Preclinical and clinical studies have indicated that combining photobiomodulation (PBM) therapy with other therapeutic approaches may influence the treatment process in a variety of disorders. The purpose of this systematic review was to determine whether PBM-combined therapy provides additional benefits over monotherapies in neurologic and neuropsychiatric disorders. In addition, the review describes
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Internal stigmatization in patients with chronic migraine and medication overuse headache BMC Neurol. (IF 2.6) Pub Date : 2024-03-19 Firdevs Ezgi Uçan Tokuç, Eylem Özaydın Göksu, Şennur Delibaş Katı
Internalized stigma can have profound effects on how individuals with migraines and other primary headache disorders see themselves and their quality of life. We aimed to investigate internalized stigma in patients with chronic migraines and medication overuse headaches. A total of 57 patients (52 women, 5 men) were included in the study, 26 of these patients were affected by chronic migraine, 31 of
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Triple platelet inhibition in intracranial thrombectomy with additional acute cervical stent angioplasty due to tandem lesion: a retrospective single-center analysis BMC Neurol. (IF 2.6) Pub Date : 2024-03-18 Ali Khanafer, Hans Henkes, Philipp Bücke, Florian Hennersdorf, Hansjörg Bäzner, Michael Forsting, Philipp von Gottberg
Acute stroke treatment with intracranial thrombectomy and treatment of ipsilateral carotid artery stenosis/occlusion (“tandem lesion”, TL) in one session is considered safe. However, the risk of stent restenosis after TL treatment is high, and antiplatelet therapy (APT) preventing restenosis must be well balanced to avoid intracranial hemorrhage. We investigated the safety and 90-day outcome of patients
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Investigating the causal relationship between immune cell and Alzheimer’s disease: a mendelian randomization analysis BMC Neurol. (IF 2.6) Pub Date : 2024-03-18 Min Shen, Linlin Zhang, Chen Chen, Xiaocen Wei, Yuning Ma, Yuxia Ma
Complex interactions between the immune system and the brain may affect neural development, survival, and function, with etiological and therapeutic implications for neurodegenerative diseases. However, previous studies investigating the association between immune inflammation and Alzheimer’s disease (AD) have yielded inconsistent results. We applied Mendelian randomization (MR) to examine the causal
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Brain frailty associated with stroke events in anterior circulation large artery occlusion BMC Neurol. (IF 2.6) Pub Date : 2024-03-18 Jing Tian, Kun Zhang, Junzhao Cui, Jin Qin, Binbin Wang, Lixia Zhou, Tong Li, Kailin Bu, Zhongzhong Li, Lin Liu, Qisong Wang, Si Yuan, Lina Ma, Ye Wang, Rui Wang, Chaoyue Meng, Biyi Zhou, Li Guo, Xiaoyun Liu
To investigate the factors associated with brain frailty and the effect of brain frailty in patients with anterior circulation large artery occlusion (AC-LAO). 1100 patients with AC-LVO consecutively admitted to the Second Hospital of Hebei Medical University, North China between June 2016 and April 2018 were retrospectively analyzed. The variables associated with brain frailty and stroke outcome were
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Defining clinical endpoints in limb girdle muscular dystrophy: a GRASP-LGMD study BMC Neurol. (IF 2.6) Pub Date : 2024-03-15 Amy Doody, Lindsay Alfano, Jordi Diaz-Manera, Linda Lowes, Tahseen Mozaffar, Katherine D. Mathews, Conrad C. Weihl, Matthew Wicklund, Man Hung, Jeffrey Statland, Nicholas E. Johnson
The Limb Girdle Muscular Dystrophies (LGMDs) are characterized by progressive weakness of the shoulder and hip girdle muscles as a result of over 30 different genetic mutations. This study is designed to develop clinical outcome assessments across the group of disorders. The primary goal of this study is to evaluate the utility of a set of outcome measures on a wide range of LGMD phenotypes and ability
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Exploring the role of mitochondrial-associated and peripheral neuropathy genes in the pathogenesis of diabetic peripheral neuropathy BMC Neurol. (IF 2.6) Pub Date : 2024-03-13 Ruojing Bai, Yuanyuan Luo
Diabetic peripheral neuropathy (DPN) is a prevalent and serious complication of diabetes mellitus, impacting the nerves in the limbs and leading to symptoms like pain, numbness, and diminished function. While the exact molecular and immune mechanisms underlying DPN remain incompletely understood, recent findings indicate that mitochondrial dysfunction may play a role in the advancement of this diabetic
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Unraveling the interplay between dyskinesia and overactive bladder symptoms in Parkinson’s disease: a comprehensive cohort study based on the long-term follow-up database of Parkinson’s disease BMC Neurol. (IF 2.6) Pub Date : 2024-03-12 Hong Jin, Yiheng Du, Jiahui Yan, Jinru Zhang, Xiaoyu Cheng, Chengjie Mao, Jing Chen, Chun-feng Liu
Overactive bladder (OAB) and dyskinesia are frequent complications in patients with Parkinson’s disease (PD). However, the correlation between OAB and dyskinesia has been insufficiently explored. The purpose of this study was to examine the relationship between dyskinesia, OAB, and clinical characteristics among individuals with PD. 1338 PD patients were included in the present study. Demographic features
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Optimized MLPA workflow for spinal muscular atrophy diagnosis: identification of a novel variant, NC_000005.10:g.(70919941_70927324)del in isolated exon 1 of SMN1 gene through long-range PCR BMC Neurol. (IF 2.6) Pub Date : 2024-03-11 Mei Yao, Liya Jiang, Yicheng Yu, Yiqin Cui, Yuwei Chen, Dongming Zhou, Feng Gao, Shanshan Mao
Spinal muscular atrophy (SMA) is a rare autosomal recessive hereditary neuromuscular disease caused by survival motor neuron 1 (SMN1) gene deletion or mutation. Homozygous deletions of exon 7 in SMN1 result in 95% of SMA cases, while the remaining 5% are caused by other pathogenic variants of SMN1. We analyzed two SMA-suspected cases that were collected, with no SMN1 gene deletion and point mutation
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Detection limitations of prion seeding activities in blood samples from patients with sporadic prion disease BMC Neurol. (IF 2.6) Pub Date : 2024-03-11 Toshiaki Nonaka, Yasushi Iwasaki, Hiroyuki Horiuchi, Katsuya Satoh
Human prion diseases (HPDs) are fatal neurodegenerative disorders characterized by abnormal prion proteins (PrPSc). However, the detection of prion seeding activity in patients with high sensitivity remains challenging. Even though real-time quaking-induced conversion (RT-QuIC) assay is suitable for detecting prion seeding activity in a variety of specimens, it shows lower accuracy when whole blood
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A systematic review and meta-analysis of clinical efficacy of early and late rehabilitation interventions for ischemic stroke BMC Neurol. (IF 2.6) Pub Date : 2024-03-08 Xufang Wei, Shengtong Sun, Manyu Zhang, Zhenqiang Zhao
At present, stroke has become the first cause of death and disability among Chinese adults. With the coming of the aging population in China, the disease burden brought by stroke will be increasingly aggravated. And stroke is a leading cause of disability. There is a golden plastic period after stroke, during which timely and safe intervention and rehabilitation therapy can effectively improve the
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High thrombin-activatable fibrinolysis inhibitor expression in thrombi from stroke patients in elevated estrogen states BMC Neurol. (IF 2.6) Pub Date : 2024-03-07 Tamanna Agarwal, Oana Madalina Mereuta, Sherief Ghozy, Jorge L Arturo Larco, Cem Bilgin, Ram Kadirvel, Waleed Brinjikji, David F Kallmes
The risk of acute ischemic stroke (AIS) associated with high estrogen states, including pregnant patients and those using oral contraceptives, has been well documented. We described the histological composition of thrombi collected in these cases. From a prospective tissue registry (STRIP registry) of thrombi retrieved during mechanical thrombectomy for AIS, we identified 5 patients with high estrogen
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Neuroanatomical and neurocognitive correlates of delusion in Alzheimer’s disease and mild cognitive impairment BMC Neurol. (IF 2.6) Pub Date : 2024-03-06 Seyul Kwak, Hairin Kim, Keun You Kim, Da Young Oh, Dasom Lee, Gieun Nam, Jun-Young Lee
Neuropsychiatric symptoms and delusions are highly prevalent among people with dementia. However, multiple roots of neurobiological bases and shared neural basis of delusion and cognitive function remain to be characterized. By utilizing a fine-grained multivariable approach, we investigated distinct neuroanatomical correlates of delusion symptoms across a large population of dementing illnesses. In
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Association between serum triglycerides and stroke type, severity, and prognosis. Analysis in 6558 patients BMC Neurol. (IF 2.6) Pub Date : 2024-03-05 Naveed Akhtar, Rajvir Singh, Saadat Kamran, Sujatha Joseph, Deborah Morgan, Ryan Ty Uy, Sarah Treit, Ashfaq Shuaib
Hypertriglyceridemia (HT) may increase the risk of stroke. Limited studies have shown that stroke severity and infarction size are smaller in patients with HT. We explored the relationship between triglyceride levels and stroke risk factors, severity and outcome in a large prospective database. Prospective Cross-sectional study. We retrospectively interrogated the Qatar Stroke Database in all patients
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Expanded clinical phenotype and untargeted metabolomics analysis in RARS2-related mitochondrial disorder: a case report BMC Neurol. (IF 2.6) Pub Date : 2024-03-04 Ameya S. Walimbe, Keren Machol, Stephen F. Kralik, Elizabeth A. Mizerik, Yoel Gofin, Mir Reza Bekheirnia, Charul Gijavanekar, Sarah H. Elsea, Lisa T. Emrick, Fernando Scaglia
RARS2-related mitochondrial disorder is an autosomal recessive mitochondrial encephalopathy caused by biallelic pathogenic variants in the gene encoding the mitochondrial arginyl-transfer RNA synthetase 2 (RARS2, MIM *611524, NM_020320.5). RARS2 catalyzes the transfer of L-arginine to its cognate tRNA during the translation of mitochondrially-encoded proteins. The classical presentation of RARS2-related
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The associations between peripheral inflammatory and lipid parameters, white matter hyperintensity, and cognitive function in patients with non-disabling ischemic cerebrovascular events BMC Neurol. (IF 2.6) Pub Date : 2024-03-04 Binghan Li, Zhengsheng Gu, Weisen Wang, Bingying Du, Chenghao Wu, Bin Li, Tianren Wang, Ge Yin, Xin Gao, Jingjing Chen, Xiaoying Bi, Hailing Zhang, Xu Sun
The global prevalence of VCI has increased steadily in recent years, but diagnostic biomarkers for VCI in patients with non-disabling ischemic cerebrovascular incidents (NICE) remain indefinite. The primary objective of this research was to investigate the relationship between peripheral serological markers, white matter damage, and cognitive function in individuals with NICE. We collected clinical
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Relationship between glycated hemoglobin levels and three-month outcomes in acute ischemic stroke patients with or without diabetes: a prospective Korean cohort study BMC Neurol. (IF 2.6) Pub Date : 2024-03-04 Changchun Cao, Tony Bowei Wang, Haofei Hu, Yong Han, Xiaohua Zhang, Yulong Wang
In patients experiencing acute ischemic stroke, there is ongoing debate surrounding the connection between chronic hyperglycemic status and their initial clinical outcomes. Our objective was to examine the connection between glycated hemoglobin (HbA1c) levels and adverse clinical outcomes at both 3-months adverse clinical outcomes in individuals with acute ischemic stroke (AIS) with and without diabetes
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Questionnaire-based study of COVID-19 vaccination induced headache: evidence of clusters of adverse events BMC Neurol. (IF 2.6) Pub Date : 2024-03-02 Qiao Zhou, Thomas Eggert, Ana Zhelyazkova, Alexander Choukér, Kristina Adorjan, Andreas Straube
The adverse events (AEs) after a Coronavirus disease 2019 (Covid-19) Pfizer-Biotech mRNA vaccination present a medical and epidemiological issue of increasing interest. Headache is the most frequent neurological adverse effect and generally the third most common adverse event after a Covid-19 vaccination, but only a few studies focus on the link between headache and other AEs after vaccination. This
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Hand knob sign in osmotic demyelinating syndrome BMC Neurol. (IF 2.6) Pub Date : 2024-03-02 Noppachai Siranart, Pannathorn Nakaphan, Vasinee Viarasilpa, Prakit Anukoolwittaya, Pasin Hemachudha
Osmotic demyelinating syndrome, commonly recognized as a consequence of the rapid correction of hyponatremia, has been known to cause motor, neuropsychiatric, or extrapyramidal symptoms. We reported a patient with an unusual presentation involving bilateral hand weakness, and pseudobulbar affect. The imaging was compatible with osmotic demyelinating syndrome with bilateral hand knob lesions, despite
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Case identification of non-traumatic brain injury in youth using linked population data BMC Neurol. (IF 2.6) Pub Date : 2024-03-02 Rebecca F Slykerman, Betony E Clasby, Jimmy Chong, Kathryn Edward, Barry J Milne, Helen Temperton, Hiran Thabrew, Nicholas Bowden
Population-level administrative data provides a cost-effective means of monitoring health outcomes and service needs of clinical populations. This study aimed to present a method for case identification of non-traumatic brain injury in population-level data and to examine the association with sociodemographic factors. An estimated resident population of youth aged 0–24 years was constructed using population-level
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Clopidogrel with indobufen or aspirin in minor ischemic stroke or high-risk transient ischemic attack: a randomized controlled clinical study BMC Neurol. (IF 2.6) Pub Date : 2024-03-01 Xudong Liu, Xuxian Lv, Yanfang Peng, Jianing Wang, Junjie Lei, Chaogang Tang, Shijian Luo, Weihua Mai, Yiming Cai, Qian Fan, Chenhao Liu, Lei Zhang
Ischemic stroke and transient ischemic attack (TIA) are the most prevalent cerebrovascular diseases. The conventional antiplatelet drugs are associated with an inherent bleeding risk, while indobufen is a new antiplatelet drug and has the similar mechanism of antiplatelet aggregation as aspirin with more safety profile. However, there have been no studies evaluating the combination therapy of indobufen