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Sex differences in interacting genetic and functional connectivity biomarkers in Alzheimer’s disease Geroscience (IF 5.6) Pub Date : 2024-04-10 Jordan N. Williamson, Shirley A. James, Sean P. Mullen, Bradley P. Sutton, Tracey Wszalek, Beni Mulyana, Peter Mukli, Andriy Yabluchanskiy, Yuan Yang
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Spousal bereavement and its effects on later life physical and cognitive capability: the Tromsø study Geroscience (IF 5.6) Pub Date : 2024-04-09 Bjørn Heine Strand, Asta K. Håberg, Harpa Sif Eyjólfsdóttir, Almar Kok, Vegard Skirbekk, Oliver Huxhold, Gøril Kvamme Løset, Carin Lennartsson, Henrik Schirmer, Katharina Herlofson, Marijke Veenstra
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The association between blood biological age at rehabilitation admission and physical activity during rehabilitation in geriatric inpatients: RESORT Geroscience (IF 5.6) Pub Date : 2024-04-09 Jessica K. Lu, Lihuan Guan, Weilan Wang, Anna G. M. Rojer, Fedor Galkin, Jorming Goh, Andrea B. Maier
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Reduced insulin/IGF-1 signalling upregulates two anti-viral immune pathways, decreases viral load and increases survival under viral infection in C. elegans Geroscience (IF 5.6) Pub Date : 2024-04-08 Elizabeth M. L. Duxbury, Hanne Carlsson, Annabel Kimberley, Yvonne Ridge, Katie Johnson, Alexei A. Maklakov
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Yoga-based lifestyle intervention for healthy ageing in older adults: a two-armed, waitlist randomized controlled trial with multiple primary outcomes Geroscience (IF 5.6) Pub Date : 2024-04-07 Atmakur Snigdha, Vijaya Majumdar, N. K. Manjunath, Amrutha Jose
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The behavioural effect of short-term cognitive and physical intervention therapies in old dogs Geroscience (IF 5.6) Pub Date : 2024-04-03
Abstract Efforts to counteract age-related decline have resulted in the emergence of various interventions. However, everyday benefits are rarely reported in elderly people. Dogs provide an excellent model for studying aging and interventions due to their similarities to humans. Our aim was to investigate whether a combined physical and cognitive intervention (most effective in humans) could enhance
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Investigating impacts of the mycothiazole chemotype as a chemical probe for the study of mitochondrial function and aging Geroscience (IF 5.6) Pub Date : 2024-04-03
Abstract Small molecule inhibitors of the mitochondrial electron transport chain (ETC) hold significant promise to provide valuable insights to the field of mitochondrial research and aging biology. In this study, we investigated two molecules: mycothiazole (MTZ) - from the marine sponge C. mycofijiensis and its more stable semisynthetic analog 8-O-acetylmycothiazole (8-OAc) as potent and selective
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DPP-4 inhibitors sitagliptin and PF-00734,200 mitigate dopaminergic neurodegeneration, neuroinflammation and behavioral impairment in the rat 6-OHDA model of Parkinson’s disease Geroscience (IF 5.6) Pub Date : 2024-04-02 Seong-Jin Yu, Yun Wang, Hui Shen, Eun-Kyung Bae, Yazhou Li, Kumar Sambamurti, Michael A. Tones, Margaret M. Zaleska, Barry J. Hoffer, Nigel H. Greig
Epidemiological studies report an elevated risk of Parkinson's disease (PD) in patients with type 2 diabetes mellitus (T2DM) that is mitigated in those prescribed dipeptidyl peptidase 4 (DPP-4) inhibitors. With an objective to characterize clinically translatable doses of DPP-4 inhibitors (gliptins) in a well-characterized PD rodent model, sitagliptin, PF-00734,200 or vehicle were orally administered
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Performance of digital technologies in assessing fall risks among older adults with cognitive impairment: a systematic review Geroscience (IF 5.6) Pub Date : 2024-03-04 Vanessa Koh, Lai Wei Xuan, Tan Kai Zhe, Navrag Singh, David B. Matchar, Angelique Chan
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Molecular cross-talk between long COVID-19 and Alzheimer’s disease Geroscience (IF 5.6) Pub Date : 2024-02-23 Magdalena Pszczołowska, Kamil Walczak, Weronika Misków, Katarzyna Antosz, Joanna Batko, Julia Karska, Jerzy Leszek
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Intermittent fasting promotes rejuvenation of immunosenescent phenotypes in aged adipose tissue Geroscience (IF 5.6) Pub Date : 2024-02-21 Kafi N. Ealey, Jacques Togo, Ju Hee Lee, Yash Patel, Jae-Ryong Kim, So-Young Park, Hoon-Ki Sung
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Senolytic treatment fails to improve ovarian reserve or fertility in female mice Geroscience (IF 5.6) Pub Date : 2024-02-15 Driele N. Garcia, Jessica D. Hense, Bianka M. Zanini, Jose V. V. Isola, Juliane B. Prosczek, Sarah Ashiqueali, Thais L. Oliveira, Jeffrey B. Mason, Ines C. Schadock, Carlos C. Barros, Michael B. Stout, Michal M. Masternak, Augusto Schneider
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Fear extinction is impaired in aged rats Geroscience (IF 5.6) Pub Date : 2024-02-13 Payton K. Robinson, Erisa Met Hoxha, Destine Williams, Kimberly P. Kinzig, Sydney Trask
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The 24-h profile of the DNA repair enzyme 8-oxoguanine glycosylase 1 (OGG1) is associated with age, TNF-α, and waist circumference in healthy adults Geroscience (IF 5.6) Pub Date : 2024-04-01 Per Arkenberg, Manuela Dittmar
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Low circulating levels of miR-17 and miR-126-3p are associated with increased mortality risk in geriatric hospitalized patients affected by cardiovascular multimorbidity Geroscience (IF 5.6) Pub Date : 2024-04-01 Francesca Marchegiani, Rina Recchioni, Mirko Di Rosa, Francesco Piacenza, Fiorella Marcheselli, Anna Rita Bonfigli, Roberta Galeazzi, Giulia Matacchione, Maurizio Cardelli, Antonio Domenico Procopio, Andrea Corsonello, Antonio Cherubini, Roberto Antonicelli, Giovanni Lombardi, Fabrizia Lattanzio, Fabiola Olivieri
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Purpose in life and slow walking speed: cross-sectional and longitudinal associations Geroscience (IF 5.6) Pub Date : 2024-01-25 Angelina R. Sutin, Sabrina Cajuste, Yannick Stephan, Martina Luchetti, Tiia Kekäläinen, Antonio Terracciano
The present research examines the association between purpose in life – a component of well-being defined as the feeling that one’s life is goal-oriented and has direction – and slow walking speed and the risk of developing slow walking speed over time. Participants (N = 18,825) were from three established longitudinal studies of older adults. At baseline, participants reported on their purpose in
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Mitochondrial complex I inhibition triggers NAD+-independent glucose oxidation via successive NADPH formation, “futile” fatty acid cycling, and FADH2 oxidation Geroscience (IF 5.6) Pub Date : 2024-01-25 Roman Abrosimov, Marius W. Baeken, Samuel Hauf, Ilka Wittig, Parvana Hajieva, Carmen E. Perrone, Bernd Moosmann
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Aging induces changes in cancer formation and microbial content in a murine model of bladder cancer Geroscience (IF 5.6) Pub Date : 2024-01-25 Benjamin L. Woolbright, Hao Xuan, Ishfaq Ahmed, Ganeshkumar Rajendran, Erika Abbott, Katie Dennis, Cuncong Zhong, Shahid Umar, John A. Taylor
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The impact of a tDCS and cognitive training intervention on task-based functional connectivity Geroscience (IF 5.6) Pub Date : 2024-01-24
Abstract Declines in several cognitive domains, most notably processing speed, occur in non-pathological aging. Given the exponential growth of the older adult population, declines in cognition serve as a significant public health issue that must be addressed. Promising studies have shown that cognitive training in older adults, particularly using the useful field of view (UFOV) paradigm, can improve
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Translatability of mouse muscle-aging for humans: the role of sex Geroscience (IF 5.6) Pub Date : 2024-01-24
Abstract Muscle-aging drives sarcopenia and is a major public health issue. Mice are frequently used as a model for human muscle-aging, however, research investigating their translational value is limited. In addition, mechanisms underlying muscle-aging may have sex-specific features in humans, but it is not yet assessed whether these are recapitulated in mice. Here, we studied the effects of aging
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The plasma metabolome is associated with preservation of physiological function following lifelong aerobic exercise in mice Geroscience (IF 5.6) Pub Date : 2024-01-24 Kevin O. Murray, Grace S. Maurer, Rachel A. Gioscia-Ryan, Melanie C. Zigler, Katelyn R. Ludwig, Angelo D’Alessandro, Julie A. Reisz, Matthew J. Rossman, Douglas R. Seals, Zachary S. Clayton
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Cardiorespiratory fitness is associated with cognitive performance in 80 + -year-olds: Detangling processing levels Geroscience (IF 5.6) Pub Date : 2024-01-23
Abstract Cardiorespiratory fitness is known to protect against cognitive decline in older adults. Specifically, it has been shown that physical activity and fitness are beneficial for executive functions that are crucial for independent living up to old age. In this study, 115 individuals aged 80 years and older underwent a cardiorespiratory fitness assessment using the two-minute step test and had
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The influence of APOE status on rate of cognitive decline Geroscience (IF 5.6) Pub Date : 2024-01-22
Abstract Background Apolipoprotein (APOE) ɛ4 positivity and subjective cognitive decline (SCD) both increase risk of Alzheimer’s disease (AD) development. However, few studies have examined the relationship between SCD and APOE status, especially using longitudinal data. The current study examined whether APOE is associated with the rate of cognitive change in SCD and mild cognitive impairment (MCI)
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The role of physical activity in the association between disability and mortality among US older adults: a nationwide prospective cohort study Geroscience (IF 5.6) Pub Date : 2024-01-22
Abstract To examine whether physical activity can mitigate the mortality risk associated with disability in activities of daily living and instrumental activities in daily living among older adults. This analysis comprised 177,360 US participants (104,556 women), aged ≥ 60 years, with valid data from the 1997 through 2018 waves of the US National Health Interview Survey. Participants reported the frequency
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Association of biological aging with frailty and post-transplant outcomes among adults with cirrhosis Geroscience (IF 5.6) Pub Date : 2024-01-21
Abstract Frailty is classically associated with advanced age but is also an important predictor of clinical outcomes in comparatively young adults with cirrhosis. We examined the association of biological aging with frailty and post-transplant outcomes in a pilot of adults with cirrhosis undergoing liver transplantation (LT). Frailty was measured via the Liver Frailty Index (LFI). The primary epigenetic
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Common synaptic inputs and persistent inward currents of vastus lateralis motor units are reduced in older male adults Geroscience (IF 5.6) Pub Date : 2024-01-19
Abstract Although muscle atrophy may partially account for age-related strength decline, it is further influenced by alterations of neural input to muscle. Persistent inward currents (PIC) and the level of common synaptic inputs to motoneurons influence neuromuscular function. However, these have not yet been described in the aged human quadriceps. High-density surface electromyography (HDsEMG) signals
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Senolytic treatment does not mitigate oxidative stress-induced muscle atrophy but improves muscle force generation in CuZn superoxide dismutase knockout mice Geroscience (IF 5.6) Pub Date : 2024-01-18 Agnieszka K. Borowik, Marcus M. Lawrence, Frederick F. Peelor, Katarzyna M. Piekarz, Abby Crosswhite, Arlan Richardson, Benjamin F. Miller, Holly Van Remmen, Jacob L. Brown
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Association of postoperative delirium with serum and cerebrospinal fluid proteomic profiles: a prospective cohort study in older hip fracture patients Geroscience (IF 5.6) Pub Date : 2024-01-18
Abstract Postoperative delirium (POD) is a common neuropsychiatric complication in geriatric inpatients after hip fracture surgery and its occurrence is associated with poor outcomes. The purpose of this study was to investigate the relationship between preoperative biomarkers in serum and cerebrospinal fluid (CSF) and the development of POD in older hip fracture patients, exploring the possibility
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Frontal–temporal regional differences in brain energy metabolism and mitochondrial function using 31P MRS in older adults Geroscience (IF 5.6) Pub Date : 2024-01-16
Abstract Aging is a major risk for cognitive decline and transition to dementia. One well-known age-related change involves decreased brain efficiency and energy production, mediated in part by changes in mitochondrial function. Damaged or dysfunctional mitochondria have been implicated in the pathogenesis of age-related neurodegenerative conditions like Alzheimer’s disease (AD). The aim of the current
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Metformin treatment of juvenile mice alters aging-related developmental and metabolic phenotypes in sex-dependent and sex-independent manners Geroscience (IF 5.6) Pub Date : 2024-01-16 Yun Zhu, Morgan Engmann, David Medina, Xiuqi Han, Pratyusa Das, Andrzej Bartke, Buffy S. Ellsworth, Rong Yuan
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Brain control of dual-task walking can be improved in aging and neurological disease Geroscience (IF 5.6) Pub Date : 2024-01-15
Abstract The peak prevalence of multiple sclerosis has shifted into older age groups, but co-occurring and possibly synergistic motoric and cognitive declines in this patient population are poorly understood. Dual-task-walking performance, subserved by the prefrontal cortex, and compromised in multiple sclerosis and aging, predicts health outcomes. Whether acute practice can improve dual-task walking
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Eliminating senescent cells by white adipose tissue–targeted senotherapy alleviates age-related hepatic steatosis through decreasing lipolysis Geroscience (IF 5.6) Pub Date : 2024-01-13
Abstract Cellular senescence is an important risk factor in the development of hepatic steatosis. Senolytics present therapeutic effects on age-related hepatic steatosis without eliminating senescent hepatocytes directly. Therefore, it highlights the need to find senolytics’ therapeutic targets. Dysfunction of adipose tissue underlies the critical pathogenesis of lipotoxicity in the liver. However
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Early neurological changes in aging cervical spine: insights from PROMIS mobility assessment Geroscience (IF 5.6) Pub Date : 2024-01-10 Sanaa Hameed, Fauziyya Muhammad, Grace Haynes, Lonnie Smith, Ali F. Khan, Zachary A. Smith
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Cell-free ascites from ovarian cancer patients induces Warburg metabolism and cell proliferation through TGFβ-ERK signaling Geroscience (IF 5.6) Pub Date : 2024-01-10 Dóra Szeőcs, Beáta Vida, Gábor Petővári, Szilárd Póliska, Eszter Janka, Adrienn Sipos, Karen Uray, Anna Sebestyén, Zoárd Krasznai, Péter Bai
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Impact of knockout of dual-specificity protein phosphatase 5 on structural and mechanical properties of rat middle cerebral arteries: implications for vascular aging Geroscience (IF 5.6) Pub Date : 2024-01-10 Chengyun Tang, Huawei Zhang, Jane J. Border, Yedan Liu, Xing Fang, Joshua R. Jefferson, Andrew Gregory, Claire Johnson, Tae Jin Lee, Shan Bai, Ashok Sharma, Seung Min Shin, Hongwei Yu, Richard J. Roman, Fan Fan
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Fisetin modulates the gut microbiota alongside biomarkers of senescence and inflammation in a DSS-induced murine model of colitis Geroscience (IF 5.6) Pub Date : 2024-01-08 Sarah A. Ashiqueali, Diptaraj Chaudhari, Xiang Zhu, Sarah Noureddine, Sarah Siddiqi, Driele N. Garcia, Aleksandra Gostynska, Maciej Stawny, Blazej Rubis, Bianka M. Zanini, Mishfak A. M. Mansoor, Augusto Schneider, Saleh A. Naser, Hariom Yadav, Michal M. Masternak
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The interplay of aging, adipose tissue, and COVID-19: a potent alliance with implications for health Geroscience (IF 5.6) Pub Date : 2024-01-08 Jorge Quarleri, M. Victoria Delpino
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Factors influencing gait performance in older adults in a dual-task paradigm Geroscience (IF 5.6) Pub Date : 2024-01-08 Karina Elizabeth Andrade Lara, José Carlos Cabrera Linares, Juan Antonio Párraga Montilla, Pedro Ángel Latorre Román
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Prognostic accuracy of 70 individual frailty biomarkers in predicting mortality in the Canadian Longitudinal Study on Aging Geroscience (IF 5.6) Pub Date : 2024-01-06 Joanna M. Blodgett, Mario Ulisses Pérez-Zepeda, Judith Godin, Dustin Scott Kehler, Melissa K. Andrew, Susan Kirkland, Kenneth Rockwood, Olga Theou
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Neutrophil, lymphocyte count, and neutrophil to lymphocyte ratio predict multimorbidity and mortality—results from the Baltimore Longitudinal Study on Aging follow-up study Geroscience (IF 5.6) Pub Date : 2024-01-06 Raffaello Pellegrino, Roberto Paganelli, Angelo Di Iorio, Stefania Bandinelli, Antimo Moretti, Giovanni Iolascon, Eleonora Sparvieri, Domiziano Tarantino, Toshiko Tanaka, Luigi Ferrucci
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Irradiation-induced hair graying in mice: an experimental model to evaluate the effectiveness of interventions targeting oxidative stress, DNA damage prevention, and cellular senescence Geroscience (IF 5.6) Pub Date : 2024-01-06
Abstract Hair graying, also known as canities or achromotrichia, is a natural phenomenon associated with aging and is influenced by external factors such as stress, environmental toxicants, and radiation exposure. Understanding the mechanisms underlying hair graying is an ideal approach for developing interventions to prevent or reverse age-related changes in regenerative tissues. Hair graying induced
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Baseline and usual triglyceride-glucose index and the risk of chronic kidney disease: a prospective cohort study Geroscience (IF 5.6) Pub Date : 2024-01-05
Abstract Triglyceride-glucose (TyG) index is an emerging marker of adverse cardiometabolic conditions such as cardiovascular disease and type 2 diabetes. The long-term relevance of TyG index to chronic kidney disease (CKD) is uncertain. We aimed to assess the association of TyG index with CKD risk and its utility in risk prediction in a prospective study. The TyG index was calculated using fasting
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Titan mice as a model to test interventions that attenuate frailty and increase longevity Geroscience (IF 5.6) Pub Date : 2024-01-05 Benedikt Gille, Annika Müller-Eigner, Shari Gottschalk, Erika Wytrwat, Martina Langhammer, Shahaf Peleg
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Longitudinal changes in the functional connectivity of individuals at risk of Alzheimer’s disease Geroscience (IF 5.6) Pub Date : 2024-01-04 Alejandra García-Colomo, Alberto Nebreda, Martín Carrasco-Gómez, Jaisalmer de Frutos-Lucas, Federico Ramirez-Toraño, Carlos Spuch, María Comis-Tuche, Ricardo Bruña, Soraya Alfonsín, Fernando Maestú
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Cell Tree Rings: the structure of somatic evolution as a human aging timer Geroscience (IF 5.6) Pub Date : 2024-01-04 Attila Csordas, Botond Sipos, Terezia Kurucova, Andrea Volfova, Frantisek Zamola, Boris Tichy, Damien G Hicks
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Modulation of movement-related oscillatory signatures by cognitive interference in healthy aging Geroscience (IF 5.6) Pub Date : 2024-01-04 Yasra Arif, Jake J. Son, Hannah J. Okelberry, Hallie J. Johnson, Madelyn P. Willett, Alex I. Wiesman, Tony W. Wilson
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Intracellular iron accumulation facilitates mycobacterial infection in old mouse macrophages Geroscience (IF 5.6) Pub Date : 2023-12-30 Stephen K. Kotey, Xuejuan Tan, Owen Fleming, Ramakrishnama Raju Kasiraju, Audrey L. Dagnell, Kyle N. Van Pelt, Janet Rogers, Steven D. Hartson, Nidheesh Thadathil, Ramasamy Selvarani, Rojina Ranjit, Sreemathi Logan, Sathyaseelan S. Deepa, Arlan Richardson, Yong Cheng
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Tobacco exposure, but not aging, shifts the frequency of peripheral blood B cell subpopulations Geroscience (IF 5.6) Pub Date : 2023-12-29 Thalyta Nery Carvalho Pinto, Cibele Cristine Berto Marques da Silva, Regina Maria Carvalho Pinto, Alberto José da Silva Duarte, Gil Benard, Juliana Ruiz Fernandes
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Association of skeletal muscle oxidative capacity with muscle function, sarcopenia-related exercise performance, and intramuscular adipose tissue in older adults Geroscience (IF 5.6) Pub Date : 2023-12-28 Akito Yoshiko, Kana Shiozawa, Shiori Niwa, Hideyuki Takahashi, Teruhiko Koike, Kohei Watanabe, Keisho Katayama, Hiroshi Akima
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Hyperbaric oxygen alleviates selective domains of cognitive and motor deficits in female 5xFAD mice Geroscience (IF 5.6) Pub Date : 2023-12-28 Paapa Mensah-Kane, Delaney L. Davis, Helen S. Shi, Oanh T. Trinh, Philip H. Vann, Ladislav Dory, Nathalie Sumien
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PEDF protects retinal pigment epithelium from ferroptosis and ameliorates dry AMD-like pathology in a murine model Geroscience (IF 5.6) Pub Date : 2023-12-28 Wei Xiang, Longhui Li, Qin Zhao, Yongcheng Zeng, Jinhui Shi, Zitong Chen, Guoquan Gao, Kunbei Lai
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Comparative study of machine learning methods for modeling associations between risk factors and future dementia cases Geroscience (IF 5.6) Pub Date : 2023-12-23 Vaka Valsdóttir, María K. Jónsdóttir, Brynja Björk Magnúsdóttir, Milan Chang, Yi-Han Hu, Vilmundur Gudnason, Lenore J. Launer, Hlynur Stefánsson
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The CEPH aging cohort and biobank: a valuable collection of biological samples from exceptionally long-lived French individuals and their offspring for longevity studies Geroscience (IF 5.6) Pub Date : 2023-12-23 Alexandre How-Kit, Mourad Sahbatou, Lise M. Hardy, Nicolas P. Tessier, Valérie Schiavon, Hélène Le Buanec, Jean-Marc Sebaoun, Hélène Blanché, Jean-François Zagury, Jean-François Deleuze
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Rejuvenation of cerebromicrovascular function in aged mice through heterochronic parabiosis: insights into neurovascular coupling and the impact of young blood factors Geroscience (IF 5.6) Pub Date : 2023-12-21 Rafal Gulej, Ádám Nyúl-Tóth, Boglarka Csik, Benjamin Petersen, Janet Faakye, Sharon Negri, Siva Sai Chandragiri, Peter Mukli, Andriy Yabluchanskiy, Shannon Conley, Derek M. Huffman, Anna Csiszar, Stefano Tarantini, Zoltan Ungvari
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The prevalence of frailty and its effect on the outcome in cardiac resynchronization therapy patients Geroscience (IF 5.6) Pub Date : 2023-12-21 Luca Katalin Kuthi, Walter Richard Schwertner, Boglárka Veres, Eperke Dóra Merkel, Richard Masszi, Anett Behon, Attila Kovács, István Osztheimer, Endre Zima, Levente Molnár, László Gellér, Annamária Kosztin, Béla Merkely
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Fingerprints of decreased cognitive performance on fractal connectivity dynamics in healthy aging Geroscience (IF 5.6) Pub Date : 2023-12-20 Zalan Kaposzta, Akos Czoch, Peter Mukli, Orestis Stylianou, Deland Hu Liu, Andras Eke, Frigyes Samuel Racz
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The effect of aperiodic components in distinguishing Alzheimer’s disease from frontotemporal dementia Geroscience (IF 5.6) Pub Date : 2023-12-19 Zhuyong Wang, Anyang Liu, Jianshen Yu, Pengfei Wang, Yuewei Bi, Sha Xue, Jiajun Zhang, Hongbo Guo, Wangming Zhang
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Recapitulation of anti-aging phenotypes by global overexpression of PTEN in mice Geroscience (IF 5.6) Pub Date : 2023-12-19 Mary Hager, Peter Chang, Michael Lee, Calvin M. Burns, S. Joseph Endicott, Richard A. Miller, Xinna Li
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PCSK9: an emerging player in cardiometabolic aging and its potential as a therapeutic target and biomarker Geroscience (IF 5.6) Pub Date : 2023-12-18 Anna Csiszar, Stefano Tarantini, Andriy Yabluchanskiy, Zoltan Ungvari
Proprotein convertase subtilisin/kexin type 9 (PCSK9), renowned for its pivotal role in low-density lipoprotein (LDL) regulation, has emerged as a compelling regulator of cardiometabolic aging. Beyond its well-established involvement in cholesterol metabolism, PCSK9’s multifaceted influence on the aging processes of the cardiovascular and metabolic systems is garnering increasing attention. This review
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Sex differences in the progression to Alzheimer’s disease: a combination of functional and structural markers Geroscience (IF 5.6) Pub Date : 2023-12-18 Alberto Fernández, Pablo Cuesta, Alberto Marcos, Mercedes Montenegro-Peña, Miguel Yus, Inmaculada Concepción Rodríguez-Rojo, Ricardo Bruña, Fernando Maestú, María Eugenia López