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Biomarker Potential of LINC00313 in Head and Neck Squamous Cell Carcinoma: Correlation with Epithelial-Mesenchymal Transition and Immune Cell Infiltration Int. J. Med. Sci. (IF 3.6) Pub Date : 2024-3-31 Yikun Ju, Fang Zhu, Bairong Fang
Although LINC00313 is dysregulated in several tumors, its role in head and neck squamous cell carcinoma (HNSC) is not fully understood. The aim of this study was to analyze the role of LINC00313 in HNSC. The clinical information and LINC00313 expression data of HNSC were mined from the TCGA/GEO/cbioportal database. The correlation between LINC00313 expression and immune cell infiltration in HNSC tumors
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Protective Effect of Fermented Sea Tangle Extract on Skin Cell Damage Caused by Particulate Matter Int. J. Med. Sci. (IF 3.6) Pub Date : 2024-3-31 Mei Jing Piao, Kyoung Ah Kang, Pincha Devage Sameera Madushan Fernando, Herath Mudiyanselage Udari Lakmini Herath, Young Sang Koh, Hee Kyoung Kang, Yung Hyun Choi, Jin Won Hyun
The skin is directly exposed to atmospheric pollutants, especially particulate matter 2.5 (PM2.5) in the air, which poses significant harm to skin health. However, limited research has been performed to identify molecules that can confer resistance to such substances. Herein, we analyzed the effect of fermented sea tangle (FST) extract on PM2.5-induced human HaCaT keratinocyte damage. Results showed
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Depression risk in chronic tonsillitis patients underwent tonsillectomy: a global federated health network analysis Int. J. Med. Sci. (IF 3.6) Pub Date : 2024-3-31 Hui-Chin Chang, MLS, Hsin-Yo Lu, Yu-Chen Guo, Chen-Yu Lin, Shiu-Jau Chen, MD, PhD, Shuo-Yan Gau
Background: Tonsillectomy is a common surgery in the US, with possible postoperative complications. While small studies indicate postoperative depressive symptoms may occur, large-scale evidence is lacking on the tonsillectomy-depression link./nMethods: We conducted a retrospective cohort study using the TriNetX US collaborative network, offering de-identified electronic health data from 59 collaborative
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Establishment of an Animal Model of Dog Bite Injuries Int. J. Med. Sci. (IF 3.6) Pub Date : 2024-3-31 Dou Huang, Wenhao Jia, Kaide Li, Zhiru Liu, Lei Liu
Nowadays dog bite is becoming a world public health problem. Therefore, the study aimed to develop a dog bite animal model that is helpful to solve these problems. In this study, the skull of an adult dog was scanned. The three-dimensional model of the dog maxillofacial bones and dentition was built by MIMICS. Next, the model was printed with Co-Cr alloy by using selective laser sintering technology
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The crucial relationship between miRNA-27 and CSE/H2S, and the mechanism of action of GLP-1 in myocardial hypertrophy Int. J. Med. Sci. (IF 3.6) Pub Date : 2024-3-31 Shan Gao, Ying Li, Mei-ming Liu, Xue Xiong, Chang-peng Cui, Qing-ji Huo, Ke-xin Li, Xun Sun, Rong Zhang, Di Wu, Bai-yan Li
Cardiac hypertrophy is the most prevalent compensatory heart disease that ultimately leads to spontaneous heart failure. Mounting evidence suggests that microRNAs (miRs) and endogenous hydrogen sulfide (H2S) play a crucial role in the regulation of cardiac hypertrophy. In this study, we aimed to investigate whether inhibition of miR-27a could protect against cardiac hypertrophy by modulating H2S signaling
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Fatty Acid Binding Protein 1 is an Independent Prognostic Biomarker for Gallbladder Cancer with Direct Hepatic Invasion Int. J. Med. Sci. (IF 3.6) Pub Date : 2024-3-25 Shimei Qiu, Zhaonan Liu, Jun Hu, Ziyi Wang, Zhuying Yue, Ziheng Jia, Wenhua Zhang, Ziru Xue, Zebing Liu, Yingbin Liu
Background: Direct liver invasion (DI) is a predominant pathway of gallbladder cancer (GBC) metastasis, but the molecular alterations associated with DI remain addressed. This study identified specific genes correlated with DI, which may offer a potential biomarker for the diagnosis and prognosis of advanced GBC./nMethods: RNA samples from 3 patients with DI of GBC were used for RNA-seq analysis. Differentially
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Hidradenitis suppurativa as a potential risk factor of periodontitis: a multi-center, propensity-score-matched cohort study Int. J. Med. Sci. (IF 3.6) Pub Date : 2024-3-25 Shuo-Yan Gau, Yu-Chen Guo, Hsin-Yo Lu, Chen-Yu Lin, Chien-Ying Lee, Ru-Yin Tsai, Hui-Chin Chang, Meng-Che Wu, Chen‐Pi Li
Background: Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease associated with systemic symptoms. Periodontitis, a prevalent dental disease, shares immune-mediated inflammatory characteristics with HS. This cohort study aims to evaluate the association between HS and periodontitis./nMethods: Using the TriNetX research network, a global-federated database of electronic health records
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A chronic stress-induced microbiome perturbation, highly enriched in Ruminococcaceae_UCG-014, promotes colorectal cancer growth and metastasis Int. J. Med. Sci. (IF 3.6) Pub Date : 2024-3-25 Ling Zhao, Xinxin Hou, Yuanyuan Feng, Yingru Zhang, Shiyun Shao, Xinnan Wu, Junfeng (Jim) Zhang, Zhaozhou Zhang
Purpose: Mounting evidence indicates that psychological stress adversely affects cancer progression including tumor growth and metastasis. The aim of this study was to investigate the role of chronic stress-induced microbiome perturbation in colorectal cancer (CRC) progression./nMethods: Chronic restraint stress (CRS) was used to establish the chronic stress mouse model, behavioral tests were used
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Prediction of outcomes for rescue cerclage in cervical insufficiency: A multicenter retrospective study Int. J. Med. Sci. (IF 3.6) Pub Date : 2024-3-25 Subeen Hong, Hyun Sik Chung, Sujin Choi, Yun Sung Jo
Purpose: Cervical insufficiency is a significant risk factor for preterm birth and miscarriage during the second trimester; cervical cerclage is a treatment option. This study seeks to evaluate the predictive roles of various clinical factors and to develop predictive models for immediate and long-term outcomes after rescue cerclage./nMethods: We conducted a multicenter retrospective study on patients
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Natural Product Quercetin-3-methyl ether Promotes Colorectal Cancer Cell Apoptosis by Downregulating Intracellular Polyamine Signaling Int. J. Med. Sci. (IF 3.6) Pub Date : 2024-3-25 Jincheng Zeng, Yuancheng Zhang, Yuming Fang, Jiachun Lian, Hailiang Zhang, Shaobing Zhang, Bihua Lin, Ziyu Ye, Caihong Li, Xianxiu Qiu, Yanfang Liang
Dysregulation of cellular metabolism is a key marker of cancer, and it is suggested that metabolism should be considered as a targeted weakness of colorectal cancer. Increased polyamine metabolism is a common metabolic change in tumors. Thus, targeting polyamine metabolism for anticancer therapy, particularly polyamine blockade therapy, has gradually become a hot topic. Quercetin-3-methyl ether is
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High-Flow Nasal Oxygen versus Conventional Nasal Cannula in Preventing Hypoxemia in Elderly Patients Undergoing Gastroscopy with Sedation: A Randomized Controlled Trial Int. J. Med. Sci. (IF 3.6) Pub Date : 2024-3-25 Xin Yin, Wen Xu, Jianlei Zhang, Mingyue Wang, Zhen Chen, Songbin Liu, Yan Xu, Shaowen Xu, Danian Ji, Jingwen Wang, Weidong Gu
Background: We aimed to compare the prevention of hypoxemia using High-flow nasal oxygen (HFNO) or regular nasal tubing (CNC) in elderly patients undergoing gastroscopy with sedation./nMethods: This study was a prospective, randomized, controlled trial conducted at a single center. We included elective patients aged 65 and above who were undergoing gastroscopy with sedation. In the intervention group
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Sudden Infant Death Syndrome (SIDS): State of the Art and Future Directions Int. J. Med. Sci. (IF 3.6) Pub Date : 2024-3-25 Oscar Fraile-Martinez, Cielo García-Montero, Sofía Castellanos Díez, Coral Bravo, María de Guadalupe Quintana-Coronado, Laura Lopez-Gonzalez, Silvestra Barrena-Blázquez, Natalio García-Honduvilla, Juan A. De León-Luis, Sonia Rodriguez-Martín, Miguel A Saez, Melchor Alvarez-Mon, Raul Diaz-Pedrero, Miguel A Ortega
Sudden infant death syndrome (SIDS) is a type of death that occurs suddenly and without any apparent explanation, affecting infants between 28 days of life and up to a year. Recognition of this entity includes performing an autopsy to determine if there is another explanation for the event and performing both an external and internal examination of the different tissues to search for possible histopathological
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The Outcomes of Patients with Omicron Variant Infection who Undergo Elective Surgery: A Propensity-score-matched Case-control Study Int. J. Med. Sci. (IF 3.6) Pub Date : 2024-3-17 Xiaojuan Xiong, Rui Li, Hong Yan, Qingxiang Mao
Aim: To investigate whether it is safe for patients with Omicron variant infection to undergo surgery during perioperative period./nMethods: A total of 3,661 surgical patients were enrolled: 3,081 who were not infected with the Omicron variant and 580 who were infected with the Omicron variant. We conducted propensity score matching (PSM) with a ratio of 1:4 and a caliper value of 0.1 to match the
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Homeobox B2 promotes malignant behavior and contributes to the radioresistance of nasopharyngeal carcinoma by regulating forkhead box protein O1 Int. J. Med. Sci. (IF 3.6) Pub Date : 2024-3-17 Jinhai Chen, MM, Min Mao, MM, Zhaoen Ma, MM, Jie Liu, MM, Minqiong Jiang, BS, Guangui Chen, MD, Yali Xu, MM
Background: Nasopharyngeal carcinoma (NPC) is an epithelial tumor of the head and neck with heterogeneous racial and geographical distributions. Homeobox B2 (HOXB2) is a tumor promoter in many cancers. However, the biological role of HOXB2 in NPC has not been elucidated./nMethods: Bioinformatics analysis was performed to identify the differentially expressed genes (DEGs) between samples of patients
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Respiratory pathogenic microbial infections: a narrative review Int. J. Med. Sci. (IF 3.6) Pub Date : 2024-3-17 Yiyin Long, Yan Zheng, Changlin Li, Zhanjun Guo, Peng Li, Fuqing Zhang, Wei Liu, Yuliang Wang
Respiratory infectious diseases have long been recognised as a substantial global healthcare burden and are one of the leading causes of death worldwide, particularly in vulnerable individuals. In the post COVID-19 era, there has been a surge in the prevalence of influenza virus A and other multiple known viruses causing cold compared with during the same period in the previous three years, which coincided
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Role of mitochondria in doxorubicin-mediated cardiotoxicity: from molecular mechanisms to therapeutic strategies Int. J. Med. Sci. (IF 3.6) Pub Date : 2024-3-11 Tianen Wang, Guoli Xing, Tong Fu, Yanchun Ma, Qi Wang, Shuxiang Zhang, Xing Chang, Ying Tong
This comprehensive review delves into the pivotal role of mitochondria in doxorubicin-induced cardiotoxicity, a significant complication limiting the clinical use of this potent anthracycline chemotherapeutic agent. Doxorubicin, while effective against various malignancies, is associated with dose-dependent cardiotoxicity, potentially leading to irreversible cardiac damage. The review meticulously
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The Expression and Prognostic Significance of ICOS in NSCLC Integrated Pan-Cancer and Multi-Omics Analyses Int. J. Med. Sci. (IF 3.6) Pub Date : 2024-3-3 Mengting Chen, Xiaotian Yan, Bo Hong, Yufei Xiao, Yun Qian
Background: Inducible co-stimulator (ICOS) shows great potential in the regulation of innate and adaptive immunity. However, previous studies of ICOS have often been limited to one or two levels./nMethods: Using the data from the online database, the immunohistochemistry, and enzyme-linked immunosorbent assays, we investigated the role of ICOS / PD-L1 on patients with NSCLC at the mRNA, protein, and
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Evaluating Novel SP-B and SP-C Synthetic Analogues for Pulmonary Surfactant Efficacy Int. J. Med. Sci. (IF 3.6) Pub Date : 2024-2-25 Chae Young Kim, Sung-Hoon Chung, Yong Sung Choi, Kyeong-Yong Park, Chong-Woo Bae
Pulmonary surfactants, a complex assembly of phospholipids and surfactant proteins such as SP-B and SP-C, are critical for maintaining respiratory system functionality by lowering surface tension (ST) and preventing alveolar collapse. Our study introduced five synthetic SP-B peptides and one SP-C peptide, leading to the synthesis of CHAsurf candidates (CHAsurf-1 to CHAsurf-5) for evaluation. We utilized
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The characterization and comorbidities of heterozygous Bardet-Biedl syndrome carriers Int. J. Med. Sci. (IF 3.6) Pub Date : 2024-2-25 Meng-Hua Li, I-Chieh Chen, Hui-Wen Yang, Hsin-Chien Yen, Yung-Chieh Huang, Chia-Chi Hsu, Yi-Ming Chen, Yu-Yuan Ke
Introduction: Bardet-Biedl syndrome (BBS) is a rare autosomal recessive disorder with clinical features of retinal dystrophy, obesity, postaxial polydactyly, renal anomalies, learning disabilities, hypogonadism, and genitourinary abnormalities. Nevertheless, previous studies on the phenotypic traits of BBS heterozygous carriers have generated inconclusive results. The aim of our study was to investigate
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Phosphoglycerate mutase 5 aggravates alcoholic liver disease through disrupting VDAC-1-dependent mitochondrial integrity Int. J. Med. Sci. (IF 3.6) Pub Date : 2024-2-25 Tian Xia, Jiachi Yu, Ye Chen, Xing Chang, Miao Meng
Alcoholic liver disease (ALD) poses a substantial global health challenge, with its pathogenesis deeply rooted in mitochondrial dysfunction. Our study explores the pivotal roles of Phosphoglycerate mutase family member 5 (Pgam5) and Voltage-Dependent Anion Channel 1 (VDAC1) in the progression of ALD, providing novel insights into their interplay and impact on mitochondrial integrity. We demonstrate
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Proteomics-based Model for Predicting the Risk of Brain Metastasis in Patients with Resected Lung Adenocarcinoma carrying the EGFR Mutation Int. J. Med. Sci. (IF 3.6) Pub Date : 2024-2-25 Qiuhua Deng, Fengnan Wang, Lei Song, Liangyu Chen, Ying Huang, Zhihua Guo, Haihong Yang
Introduction: Epidermal growth factor receptor (EGFR) mutation is common in Chinese patients with lung adenocarcinoma (LUAD). Brain metastases (BMs) is high and associated with poor prognosis. Identification of EGFR-mutant patients at high risk of developing BMs is important to reduce or delay the incidence of BMs. Currently, there is no literature on the prediction and modeling of EGFR brain metastasis
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Impact of Omicron variant infection on the liver, kidney, and coagulation system in patients undergoing elective surgery: a retrospective case-control study Int. J. Med. Sci. (IF 3.6) Pub Date : 2024-2-17 Xiaojuan Xiong, Rui Li, Haoyu Pei, Qingxiang Mao
Purpose: We aimed to investigate the impact of Omicron variant infection on the perioperative organ function in patients undergoing elective surgery./nMethods: A total of 5029 patients who underwent elective surgery between October 2022 and January 2023 at our hospital were enrolled. Among them, the patients who underwent elective surgery between October 2022 and November 2022 composed Group 1 (not
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Hyperoside induces cell cycle arrest and suppresses tumorigenesis in bladder cancer through the interaction of EGFR-Ras and Fas signaling pathways Int. J. Med. Sci. (IF 3.6) Pub Date : 2024-2-12 Kai Yang, Zhi-Xiang Qi, Ming-Xin Sun, Li-Ping Xie
Hyperoside is a natural flavonol glycoside widely found in plants and has been reported to have a variety of pharmacological effects, including anticancer abilities. In this study, we demonstrated for the first time that hyperoside inhibited the proliferation of bladder cancer cells in vitro and in vivo. Moreover, hyperoside could not only induce cell cycle arrest, but also induce apoptosis of a few
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Roxadustat Versus Erythropoietin: The Comparison of Efficacy in Reversing Ventricular Remodeling in Dialysis Patients with Anaemia Int. J. Med. Sci. (IF 3.6) Pub Date : 2024-2-12 Meng Ying Wang, Xiao Qi Liu, Ting Ting Jiang, Wen Tao Liu, Yang Huang, Yu Lin Huang, Feng Yong Jin, Qing Zhao, Qin Yi Wu, Gui Hua Wang, Xiong Zhong Ruan, Kun Ling Ma
Background: Renal anaemia and left ventricular hypertrophy are the main complications of chronic kidney disease and are shared among dialysis patients. This retrospective study aimed to compare the efficacies of the hypoxia-inducible factor prolyl hydroxylase inhibitor roxadustat and recombinant human erythropoietin in reversing ventricular remodeling in dialysis patients with renal anaemia./nMethods:
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The DNA-dependent protein kinase catalytic subunit promotes sepsis-induced cardiac dysfunction through disrupting INF-2-dependent mitochondrial dynamics Int. J. Med. Sci. (IF 3.6) Pub Date : 2024-2-12 Mudi Ma, Hao Zhou, Ying Zhang, Woliang Yuan, Chaoxiong Chen
Sepsis-induced cardiomyopathy (SIC) represents a severe complication of systemic infection, characterized by significant cardiac dysfunction. This study examines the role of DNA-dependent protein kinase catalytic subunit (DNA-PKcs) and Inverted Formin 2 (INF2) in the pathogenesis of SIC, focusing on their impact on mitochondrial homeostasis and dynamics. Our research demonstrates that silencing DNA-PKcs
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A comparative analysis of the doctoral regulations at the medical faculties in Germany Int. J. Med. Sci. (IF 3.6) Pub Date : 2024-2-12 Sarah Altenberger, Roman Leischik, Richard Vollenberg, Jan Peter Ehlers, Markus Strauss
Objective: In order to be allowed to use the title “Dr. med.” in Germany, an independent scientific achievement under the supervision of an established scientist is necessary. The research question, analysis and results are essentially carried out and developed independently by the doctoral student. The doctorate serves as proof that the doctoral candidate is capable of independent academic work. The
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The Protein Acetylation after Traumatic Spinal Cord Injury: Mechanisms and Therapeutic Opportunities Int. J. Med. Sci. (IF 3.6) Pub Date : 2024-2-12 Hong-wei Li, Hai-hong Zhang
Spinal cord injury (SCI) leads to deficits of various normal functions and is difficult to return to a normal state. Histone and non-histone protein acetylation after SCI is well documented and regulates spinal cord plasticity, axonal growth, and sensory axon regeneration. However, our understanding of protein acetylation after SCI is still limited. In this review, we summarize current research on
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METTL3 Promotes Osteogenic Differentiation of Human Periodontal Ligament Stem Cells through IGF2BP1-Mediated Regulation of Runx2 Stability Int. J. Med. Sci. (IF 3.6) Pub Date : 2024-2-4 Xuefei Sun, Xiujiao Meng, Yu Piao, Shaojie Dong, Qianqian Dong
N6-Methyladenosine (m6A) has been reported to play a dynamic role in osteoporosis and bone metabolism. However, whether m6A is involved in the osteogenic differentiation of human periodontal ligament stem cells (hPDLSCs) remains unclear. Here, we found that methyltransferase-like 3 (METTL3) was up-regulated synchronously with m6A during the osteogenic differentiation of hPDLSCs. Functionally, lentivirus-mediated
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Development and validation of a diagnostic nomogram to evaluate tubular atrophy/interstitial fibrosis of IgA nephropathy Int. J. Med. Sci. (IF 3.6) Pub Date : 2024-2-4 Yangang Gan, Yihuan Cai, Jiajia Li, Jianping Wu, Rui Zhang, Qianqian Han, Wenchao Li, Qiongqiong Yang
Background: IgA nephropathy (IgAN) is a cause of chronic kidney disease (CKD). Tubular atrophy/interstitial fibrosis is associated with IgAN prognosis. However, simple tools for predicting pathological lesions of IgAN remain limited. Our objective was to develop a tool for evaluating tubular atrophy/interstitial fibrosis in patients with IgAN./nMethods: In this cross-sectional study, 410 biopsy-verified
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Rosmarinic Acid Protects Skin Keratinocytes from Particulate Matter 2.5-Induced Apoptosis Int. J. Med. Sci. (IF 3.6) Pub Date : 2024-2-4 Herath Mudiyanselage Udari Lakmini Herath, Mei Jing Piao, Kyoung Ah Kang, Pincha Devage Sameera Madushan Fernando, Jin Won Hyun
Background: The exposure of the human skin to particulate matter 2.5 (PM2.5) results in adverse health outcomes, such as skin aging, wrinkle formation, pigment spots, and atopic dermatitis. It has previously been shown that rosmarinic acid (RA) can protect keratinocytes from ultraviolet B radiation by enhancing cellular antioxidant systems and reducing oxidative damage; however, its protective action
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Comparing the Long-Term Cardiovascular Outcomes of Lumbo-Peritoneal, Ventriculo-Peritoneal, or Non-Shunting Treatment after Idiopathic Normal Pressure Hydrocephalus: A Nationwide Retrospective Cohort Study Int. J. Med. Sci. (IF 3.6) Pub Date : 2024-1-27 Cheng-Di Chiu, MD, MBA, PhD, Po-Fan Chiu, MD, Chih-Ying Wu, MD, Hei-Tung Yip, MSc, You-Pen Chiu, MSc, Hui-Ru Ji, MSc, Kai-Cheng Hsu, MD, PhD, Fuu-Jen Tsai, MD, PhD, Robert Chen-Hao Chang, PhD
Purpose: With advances in medical technology, the average lifespan has increased, leading to a growing significance of idiopathic normal pressure hydrocephalus (iNPH), particularly in the elderly population. Most patients with iNPH have been treated either with ventriculo-peritoneal shunts (VPS) or conservative measures. However, lumbo-peritoneal shunts (LPS) have emerged as an alternative treatment
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Comprehensive study on the differential extraction and comparison of bioactive health potential of the Broccoli (Brassica oleracea) Int. J. Med. Sci. (IF 3.6) Pub Date : 2024-1-21 Durga Uvaraj, Naiyf S. Alharbi, Shine Kadaikunnan, Muthu Thiruvengadam, Baskar Venkidasamy
Introduction: Broccoli is a cruciferous vegetable that has been shown to have numerous potential therapeutic benefits because of its bioactive compounds./nMethods: In this study, we compared the bioactive efficacy of cooked and uncooked (fresh) stems and florets of broccoli extracted with three different solvents: acetonitrile, methanol, and aqueous extracts. The extraction yield and antioxidant and
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Enhanced Diagnostic Efficiency of Endometrial Carcinogenesis and Progression in Women with Abnormal Uterine Bleeding through Peripheral Blood Cytokine Testing: A Multicenter Retrospective Cohort Study Int. J. Med. Sci. (IF 3.6) Pub Date : 2024-1-21 Jincheng Ma, Dabin Liu, Xiaodan Mao, Leyi Huang, Yuan Ren, Xiaozhen Xu, Xiaoli Huang, Caiping Deng, Feifeng Shi, Pengming Sun
Objective: This study aimed to evaluate the role of plasma cytokine detection in endometrial cancer screening and tumor progression assessment in patients with abnormal uterine bleeding./nMethods: In this multicenter retrospective cohort study of 287 patients with abnormal uterine bleeding, comprehensive clinical information and laboratory assessments, including cytokines, routine blood tests, and
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Oridonin inhibited epithelial-mesenchymal transition of laryngeal carcinoma by positively regulating LKB1/AMPK signaling Int. J. Med. Sci. (IF 3.6) Pub Date : 2024-1-21 Bo Kou, Yuhan Shi, Zhaoyue Zhou, Yanning Yun, Qun Wu, Jinsong Zhou, Wei Liu
Oridonin is the main bioactive component of Rabdosia rubescens, and its anticancer activity has been reported in a variety of cancers. However, the molecular mechanism of oridonin in laryngeal carcinoma remains unclear. In the present study, the cytotoxic effect of oridonin on laryngeal carcinoma Hep-2 and TU212 cell lines were initially detected by modified MTT assay. The results showed that oridonin
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PKM2 interacts with and phosphorylates PHB2 to sustain mitochondrial quality control against septic cerebral-cardiac injury Int. J. Med. Sci. (IF 3.6) Pub Date : 2024-1-21 Yuanchen Zhao, Yawen Pan, Mengyuan Chen, Ying Tan, Xing Chang, Haixia Li, Yinghao Zhi
Sepsis induces profound disruptions in cellular homeostasis, particularly impacting mitochondrial function in cardiovascular and cerebrovascular systems. This study elucidates the regulatory role of the Pyruvate Kinase M2 (PKM2)- Prohibitin 2 (PHB2) axis in mitochondrial quality control during septic challenges and its protective effects against myocardial and cerebral injuries. Employing LPS-induced
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Effects of Banhabaekchulcheonma-Tang on Brain Injury and Cognitive Function Impairment Caused by Bilateral Common Carotid Artery Stenosis in a Mouse Model Int. J. Med. Sci. (IF 3.6) Pub Date : 2024-1-21 Da-Woon Kim, Jung-Hwa Lim, Suin Cho, Sang-Ho Kim
Vascular dementia (VD) is the second most prevalent dementia type, with no drugs approved for its treatment. Here, the effects of Banhabaekchulcheonma-Tang (BBCT) on ischemic brain injury and cognitive function impairment were investigated in a bilateral carotid artery stenosis (BCAS) mouse model. Mice were divided into sham-operated, BCAS control, L-BBCT (40 ml/kg), and H-BBCT (80 ml/kg) groups. BBCT's
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Ferroptosis: A New Mechanism in Diabetic Cardiomyopathy Int. J. Med. Sci. (IF 3.6) Pub Date : 2024-1-21 Zichong Song, Jingyi Wang, Lijun Zhang
Diabetic cardiomyopathy (DC) is a pathophysiologic condition caused by diabetes mellitus (DM) in the absence of coronary artery disease, valvular heart disease, and hypertension that can lead to heart failure (HF), manifesting itself in the early stages with left ventricular hypertrophy and diastolic dysfunction, with marked HF and decreased systolic function in the later stages. There is still a lack
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The effect of combining prewarming with intraoperative phenylephrine infusion on the prevention of hypothermia in patients undergoing urological surgery: a prospective, randomized, and controlled trial. Int. J. Med. Sci. (IF 3.6) Pub Date : 2023-10-24 Sung-Ae Cho,Seok-Jin Lee,Jun-Ho Kim,Woojin Kwon,Tae-Yun Sung
Background: Hypothermia is common in patients undergoing urological surgery; however, no single preventative modality is completely effective. This study evaluated the effects of combining prewarming with intraoperative phenylephrine infusion for the prevention of hypothermia in patients undergoing urological surgery. Methods: This prospective study enrolled 58 patients scheduled for urological surgery
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Objective Assessment of Perioperative Anxiety using Functional Near-infrared Spectroscopy in Elderly Patients: A Prospective Randomized Observational Pilot Study. Int. J. Med. Sci. (IF 3.6) Pub Date : 2023-10-24 Hyae Jin Kim,Dowon Lee,Hyun-Su Ri,JongKwan Choi,Jinhyung Choi,Seung Joon Rhee,Jiseok Baik,Boo-Young Hwang,Gayoung Park,Jihyun Cha,Sang Don Lee
Background: Assessing and managing patient anxiety is essential to reduce postoperative complications in elderly patients. However, monitoring patient anxiety objectively is impossible. This study aimed to investigate the correlation between the level of fNIRS signals and anxiety in patients aged 65 and older undergoing artificial joint replacement surgery. Material and Methods: Sixty patients aged
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Custom-made Subperiosteal Implants: A Finite Element Analysis on Monoblock and Dual Implant Systems in Atrophic Maxilla. Int. J. Med. Sci. (IF 3.6) Pub Date : 2023-10-16 Mustafa Ayhan,Abdulkadir Burak Cankaya
This study aims to investigate and compare the stress distribution, displacement, and bone loading of monoblock and dual custom-made subperiosteal implant systems in atrophic maxilla using finite element analysis (FEA). A total of 11 patients with insufficient bone tissue for conventional implant treatment were included in the study. Customized subperiosteal implant designs were generated using the
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TMED family genes and their roles in human diseases. Int. J. Med. Sci. (IF 3.6) Pub Date : 2023-10-16 Lv Zhou,Huaixu Li,Hui Yao,Xingliang Dai,Peng Gao,Hongwei Cheng
The members of the transmembrane emp24 domain-containing protein (TMED) family are summarized in human as four subfamilies, α (TMED 4, 9), β (TMED 2), γ (TMED1, 3, 5, 6, 7) and δ (TMED 10), with a total of nine members, which are important regulators of intracellular protein transport and are involved in normal embryonic development, as well as in the pathogenic processes of many human diseases. Here
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Extracellular Vesicles in Sepsis: Pathogenic Roles, Organ Damage, and Therapeutic Implications. Int. J. Med. Sci. (IF 3.6) Pub Date : 2023-10-16 Ni An,Zhe Chen,Peng Zhao,Wen Yin
Despite significant advances in anti-infective treatment and organ function support technology in recent years, the mortality rate of sepsis remains high. In addition to the high costs of sepsis treatment, the increasing consumption of medical resources also aggravates economic pressure and social burden. Extracellular vesicles (EVs) are membrane vesicles released from different types of activated
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Increased Expression of Tetraspanins, ALIX and HSP-70 in the Placenta Tissue of Women with Chronic Venous Disease during Pregnancy. Int. J. Med. Sci. (IF 3.6) Pub Date : 2023-10-16 Miguel A Ortega,María Asunción Sánchez-Gil,Oscar Fraile-Martínez,Cielo García-Montero,Luis G Guijarro,Raúl Diaz-Pedrero,Laura Lopez-Gonzalez,Juan De Leon-Luis,Coral Bravo,Melchor Álvarez-Mon,Julia Bujan,Miguel A Saez,Natalio García-Honduvilla
Chronic venous disease (CVD) is a complex and common vascular disorder characterized by increased blood pressure and morpho-functional changes in the venous system like varicose veins. Pregnancy is one of the main risk factors for suffering from this condition. Despite the consequences of CVD during pregnancy remains to be fully understood, compelling evidence support that this condition represents
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Utilization of sodium-glucose cotransporter 2 inhibitors on dry eye disease severity in patients with type 2 diabetes mellitus. Int. J. Med. Sci. (IF 3.6) Pub Date : 2023-10-09 Yen-Po Yao,Po-Jen Yang,Chia-Yi Lee,Jing-Yang Huang,Shun-Fa Yang,Hung-Yu Lin
Sodium-glucose cotransporter 2 (SGLT2) inhibitors have protective effects against various systemic diseases and neoplasms. This retrospective cohort study evaluated the severity of dry eye disease (DED) in patients with type 2 diabetes mellitus (T2DM) who were treated with SGLT2 inhibitors. Data were obtained from the National Health Insurance Research Database of Taiwan. Patients with T2DM who were
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Use of metagenomic next-generation sequencing for diagnosis of peritonitis in end-stage liver disease. Int. J. Med. Sci. (IF 3.6) Pub Date : 2023-10-09 Taiyu He,Ning Luo,Juan Kang,Ning Ling,Dazhi Zhang
Background: Conventional methods are low in positive rates and time-consuming for ascites pathogen detection in patients with end-stage liver disease (ESLD). With many advantages, metagenomic next-generation sequencing (mNGS) may be a good alternative method. However, the related studies are still lacking. Methods: Ascites from 50 ESLD patients were sampled for pathogen detection using mNGS and conventional
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The effects of E'Jiao on body composition, bone marrow adiposity and skeletal redox status in ovariectomised rats. Int. J. Med. Sci. (IF 3.6) Pub Date : 2023-10-09 Sophia Ogechi Ekeuku,Kok-Yong Chin,Jing Qian,Yan Zhang,Haibin Qu,Fairus Ahmad,Sok Kuan Wong,Mohd Mustazil Mohd Noor,Ima Nirwana Soelaiman
Background: Menopause is accompanied by increased oxidative stress, partly contributing to weight gain and bone marrow adiposity. Traditional Chinese medication, E'Jiao, has been demonstrated to reduce excessive bone remodelling during oestrogen deprivation, but its effects on body composition and bone marrow adiposity during menopause remain elusive. Objective: To determine the effects of E'Jiao on
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Strontium Ranelate Ameliorates Intervertebral Disc Degeneration via Regulating TGF-β1/NF-κB Axis. Int. J. Med. Sci. (IF 3.6) Pub Date : 2023-10-07 Ruping Sun,Jian Zhu,Kaiqiang Sun,Lu Gao,Bing Zheng,Jiangang Shi
Intervertebral disc degeneration (IVDD) is a prevalent and debilitating condition characterized by chronic back pain and reduced quality of life. Strontium ranelate (SRR) is a compound traditionally used for treating osteoporosis via activating TGF-β1 signaling pathway. Recent studies have proved the anti-inflammatory effect of SRR on chondrocytes. Although the exact mechanism of IVDD remains unclear
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The Structural Proteins of Membrane Rafts, Caveolins and Flotillins, in Lung Cancer: More Than Just Scaffold Elements. Int. J. Med. Sci. (IF 3.6) Pub Date : 2023-10-02 Ana Karina Saldaña-Villa,Roberto Lara-Lemus
Lung cancer is one of the most frequently diagnosed cancers worldwide. Due to its late diagnosis, it remains the leading cause of cancer-related deaths. Despite it is mostly associated to tobacco smoking, recent data suggested that genetic factors are of the highest importance. In this context, different processes meaningful for the development and progression of lung cancer such endocytosis, protein
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Efficacy of levocetirizine in isolated rat tracheal smooth muscle. Int. J. Med. Sci. (IF 3.6) Pub Date : 2023-10-02 Ying-Liang Chou,Yueh-Ting Wang,Li-Hsiang Cheng,Shao-Cheng Liu,Hsing-Won Wang
Histamine receptor-1 (H1) antagonists like levocetirizine are frequently used nowadays to treat rhinitis patients who experience rhinorrhea and sneezing. The trachea may be affected by the H1 antagonist when it is used to treat nasal symptoms, either orally or through inhalation. The purpose of this study was to ascertain in vitro effects of levocetirizine on isolated tracheal smooth muscle. As a parasympathetic
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Preclinical models for Type 1 Diabetes Mellitus - A practical approach for research. Int. J. Med. Sci. (IF 3.6) Pub Date : 2023-10-02 Xi Peng,Guocheng Rao,Xinqiong Li,Nanwei Tong,Yan Tian,Xianghui Fu
Numerous preclinical models have been developed to advance biomedical research in type 1 diabetes mellitus (T1DM). They are essential for improving our knowledge of T1DM development and progression, allowing researchers to identify potential therapeutic targets and evaluate the effectiveness of new medications. A deeper comprehension of these models themselves is critical not only to determine the
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Tumor necrosis factor-alpha mediates the negative association between telomere length and kidney dysfunction. Int. J. Med. Sci. (IF 3.6) Pub Date : 2023-09-25 Mengya Qi,Jie Yu,Fan Ping,Lingling Xu,Wei Li,Huabing Zhang,Yuxiu Li
Aim/hypothesis: The relationship between peripheral blood leukocyte telomere length (LTL) and kidney dysfunction, especially in people with hypertension, remains unclear. No clinical study has explored the role of inflammation and oxidative stress in the relationship between LTL and kidney dysfunction. Therefore, we examined the relationship between baseline LTL and albuminuria progression and/or rapid
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Uric acid-based ratios for predicting renal failure in Chinese IgA nephropathy patients. Int. J. Med. Sci. (IF 3.6) Pub Date : 2023-09-25 Aiya Qin,Dandan Yang,Siqing Wang,Lingqiu Dong,Jiaxing Tan,Yi Tang,Wei Qin
Objective: The uric acid/albumin ratio (UAR), a novel, simple, and compositive laboratory biomarker, has recently attracted attention for predicting disease prediction and disease prognosis. However, whether uric acid-related biomarkers (especially UAR) could serve as prognostic indicator for IgAN is unclear. Methods: In this retrospective cohort study, biopsy-confirmed IgAN patients from 2009 to 2017
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Identification of lncRNAs associated with uterine corpus endometrial cancer prognosis based on the competing endogenous RNA network. Int. J. Med. Sci. (IF 3.6) Pub Date : 2023-09-25 Liangxiao Wang,Xianwei Su,Liangyu Wang,Jianbo Luo,Zhiqiang Xiong,Geoffrey Ho Duen Leung,Jingye Zhou,Guang Yang,Li Zhai,Xi Zhang,Qiang Liu,Gang Lu,Yuming Wang
Uterine Corpus Endometrial Carcinoma (UCEC) is one of the major malignant tumors of the female reproductive system. However, there are limitations in the currently available diagnostic approaches for UCEC. Long non-coding RNAs (lncRNAs) play important roles in regulating biological processes as competitive endogenous RNA (ceRNA) in tumors. To study the potential of lncRNAs as non-invasive diagnostic
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GAS1 Promotes Ferroptosis of Liver Cells in Acetaminophen-Induced Acute Liver Failure. Int. J. Med. Sci. (IF 3.6) Pub Date : 2023-09-25 Jinqiu Tao,Cailin Xue,Xiaodong Wang,Huihui Chen,Qiaoyu Liu,Chunping Jiang,Wenjie Zhang
Purpose: Acute liver failure (ALF) is a clinically fatal disease that leads to the rapid loss of normal liver function. Acetaminophen (APAP) is a leading cause of drug-induced ALF. Ferroptosis, defined as iron-dependent cell death associated with lipid peroxide accumulation, has been shown to be strongly associated with APAP-induced liver injury. Growth arrest-specific 1 (GAS1) is a growth arrest-specific
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DKK1 Ameliorates Myofibroblast Differentiation in Urethral Fibrosis in Vivo and in Vitro by Regulating the Canonical Wnt Pathway. Int. J. Med. Sci. (IF 3.6) Pub Date : 2023-09-25 Shanlong Huang,Delai Fu,Ziyan Wan,Zhixin Huang,Min Li,Hecheng Li,Tie Chong
Background: Urethral stricture is a common disorder of the lower urinary tract in men. A complex network of pathways and interactions are involved in the pathogenesis of urethral fibrosis. However, the mechanisms underlying urethral fibrosis remain poorly understood. Objectives: To investigate the critical role of the canonical Wnt pathway in development of urethral fibrosis and explore DKK1, the endogenous
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Artesunate induces ferroptosis by inhibiting the nuclear localization of SREBP2 in myeloma cells. Int. J. Med. Sci. (IF 3.6) Pub Date : 2023-09-18 Laoqi Liang,Yang Liu,Xiaoyan Wu,Yan Chen
Objective: Multiple myeloma (MM) is an incurable haematological cancer characterized by abnormal proliferation of plasma cells. The promising therapeutic effect of selective inhibitors of nuclear export in MM reveals the broad therapeutic prospects of nuclear localization intervention. Sterol regulatory element binding protein 2 (SREBP2) is a lipid regulatory molecule that has been implicated in the
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Intermittent Hypoxia Conditioning: A Potential Multi-Organ Protective Therapeutic Strategy. Int. J. Med. Sci. (IF 3.6) Pub Date : 2023-09-18 Qihan Zhang,Wenbo Zhao,Sijie Li,Yuchuan Ding,Yuan Wang,Xunming Ji
Severe hypoxia can induce a range of systemic disorders; however, surprising resilience can be obtained through sublethal adaptation to hypoxia, a process termed as hypoxic conditioning. A particular form of this strategy, known as intermittent hypoxia conditioning hormesis, alternates exposure to hypoxic and normoxic conditions, facilitating adaptation to reduced oxygen availability. This technique
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Critical Overview on Pure Chitosan-based Scaffolds for Bone Tissue Engineering: Clinical insights in Dentistry. Int. J. Med. Sci. (IF 3.6) Pub Date : 2023-09-18 Luca Signorini,Gaetano Marenzi,Anastasia Facente,Benedetta Marrelli,Rosa Maria Marano,Alessandra Valletta,Luciano Pacifici,Roberta Gasparro,Gilberto Sammartino,Marco Severino
Bone Tissue Engineering (BTE) is a field of regenerative medicine continuously improving, thanks to the development of new biomaterials used as grafts or scaffolds for repairing bone defects. In recent years, chitosan, a natural biopolymer extracted mainly from crustacean shells, has demonstrated unique and desirable characteristics for BTE applications, such as: biocompatibility, biodegradability
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High-dose remifentanil exacerbates myocardial ischemia-reperfusion injury through activation of calcium-sensing receptor-mediated pyroptosis. Int. J. Med. Sci. (IF 3.6) Pub Date : 2023-09-18 Yejing Zhu,Jinyu Chi,Shunv Cai,Siqi Liu,Junbo Yuan,Hongliang Xu,Huidan Zhou
Background: The aim of this study was to investigate whether calcium-sensing receptor (CaSR) was involved in HRF-mediated exacerbation of MI/R injury through NLRP3 inflammasome activation and pyroptosis. Methods: In vivo, a rat MI/R model was established by ligating the left coronary artery, and short-term HRF exposure was induced during reoxygenation. Then, TUNEL, H&E, Masson staining, immunohistochemical
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Decreased miR-329-3p upregulates Adamts4 and Dnajb1 in mouse hepatic I/R injury in an age-independent manner. Int. J. Med. Sci. (IF 3.6) Pub Date : 2023-09-18 Lin Zhu,Wu Duan,Bo Yang,Lan Wang
Introduction: Hepatic ischemia/reperfusion (I/R) injury is common after liver surgery, particularly in patients of older age. However, an understanding of the mechanism of injury remains incomplete. In this study, we explored the molecular mechanisms underlying hepatic I/R injury and associations with age in a murine model. Methods: Gene expression profiling datasets (GSE72315 and GSE10654) and a microRNA