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Utility of 18F-FDG PET/CT in Treatment Strategies for Patients With Cancer of Unknown Primary: A Single-Center, Retrospective Change-in-Management Study Clin. Med. Insights Oncol. (IF 1.795) Pub Date : 2024-04-22 Rong Huang, Yuxiao Hu, Yun Zhang
Background:Cancer of unknown primary (CUP) is difficult to diagnose and classify clinically, and the disease develops rapidly. Therefore, the primary tumor detected in patients with CUP plays a profound role in the diagnosis and treatment of patients. The search for the primary tumor of CUP is also one of the indications for 18F-fluoro-2-deoxyglucose-positron emission tomography and computed tomography
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Recent Progress of Bioinspired Cell Membrane in Cancer Immunotherapy Clin. Med. Insights Oncol. (IF 1.795) Pub Date : 2024-04-20 Min Zhang, Yuanhang Wang, Zhiyuan Song, Yimeng Lu, Houyu Zhao, Yihan Wang, Ping Lu, Yanting Liu
By modifying immune cells, immunotherapy can activate immune response to establish long-term immune memory and prevent tumor recurrence. However, their effectiveness is largely constricted by the poor immunogenicity, immune escape, and immune tolerance of the tumor. This is related to the characteristics of the tumor itself, such as genome instability and mutation. The combination of various nanocarriers
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Prediction of High-Risk Gastrointestinal Stromal Tumor Recurrence Based on Delta-CT Radiomics Modeling: A 3-Year Follow-up Study After Surgery Clin. Med. Insights Oncol. (IF 1.795) Pub Date : 2024-04-16 Xianqun Ji, Yu Shang, Lin Tan, Yan Hu, Junjie Liu, Lina Song, Junyan Zhang, Jingxian Wang, Yingjian Ye, Haidong Zhang, Tianfang Peng, Peng An
Background:Medium- to high-risk classification-gastrointestinal stromal tumors (MH-GIST) have a high recurrence rate and are difficult to treat. This study aims to predict the recurrence of MH-GIST within 3 years after surgery based on clinical data and preoperative Delta-CT Radiomics modeling.Methods:A retrospective analysis was conducted on clinical imaging data of 242 cases confirmed to have MH-GIST
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MiR-339-5p Inhibits Ferroptosis by Promoting Autophagic Degradation of FTH1 Through Targeting ATG7 in Liver Cancer Cells Clin. Med. Insights Oncol. (IF 1.795) Pub Date : 2024-04-16 Fei Cao, Weiyuan Hao, Weiren Liang, Hui Zeng, Jiaping Zheng
Background:Liver cancer has a high incidence and mortality rate worldwide, and there is an urgent need to identify new therapeutic strategies and predictive targets to improve the clinical outcomes of advanced liver cancer. Ferroptosis holds promise as a novel strategy for cancer therapy. Epigenetic dysregulation is a hallmark of cancer, and noncoding RNAs are tightly involved in cell fate determination
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Diagnostic Performance of Node Reporting and Data System Magnetic Resonance Imaging Score in Detecting Metastatic Cervical Lymph Nodes of Nasopharyngeal Carcinoma Clin. Med. Insights Oncol. (IF 1.795) Pub Date : 2024-04-02 Xinggang Yang, Jiaqing Yang, Jia Li, Junyan Leng, Yu Qiu, Xuelei Ma
Background:The Node Reporting and Data System (Node-RADS) is a recently proposed classification system for the categorization of lymph nodes in radiological images. This study was conducted to retrospectively evaluate the diagnostic accuracy of the Node-RADS score for metastatic cervical lymph nodes on magnetic resonance imaging (MRI) of patients with nasopharyngeal carcinoma (NPC).Methods:We retrospectively
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Cardiac Morbidity and Mortality in Patients with Sarcoma: A Population-Based Study Clin. Med. Insights Oncol. (IF 1.795) Pub Date : 2024-03-28 Rakan Alanazi, Ahmed Aljizeeri, Ahmed Alsaileek, Azzam Alrashid, Ashwaq Alolayan, Mohammad Alkaiyat, Basel Alenazy, Hussam Shehata, Joud Alqahtani, Husam Ardah, Kanan Alshammari
Background:Soft tissue sarcoma (STS) is a rare malignancy that affects soft tissues. It encompasses various subtypes and requires different treatment strategies. Doxorubicin is a commonly used anthracycline in the management of localized and metastatic STS. However, high doses of doxorubicin are associated with cardiotoxicity, which can significantly impact patients’ long-term outcomes. This study
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Helicobacter pylori and Gastrointestinal Cancers: Recent Advances and Controversies Clin. Med. Insights Oncol. (IF 1.795) Pub Date : 2024-03-28 Chuandong Zhang, Yuqi Chen, Yan Long, Huimin Zheng, Jiyong Jing, Wensheng Pan
Helicobacter pylori ( H pylori), a gastric bacterium, has been extensively studied for its association with gastritis, peptic ulcers, and gastric cancer. However, recent evidence suggests its potential implications beyond the stomach, linking it to other gastrointestinal malignancies, such as esophageal cancer, liver cancer, pancreatic cancer, gallbladder cancer, and colorectal cancer. In light of
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Enumeration and Molecular Characterization of Circulating Tumor Cell Using an Epithelial Cell Adhesion Molecule/Vimentin/Epidermal Growth Factor Receptor Joint Capture System in Lung Cancer Clin. Med. Insights Oncol. (IF 1.795) Pub Date : 2024-03-23 Wentan Jiang, Jingyang Wu, Xianbin Lin, Zhiyao Chen, Liangan Lin, Jiansheng Yang
Background:Detection rate and isolation yield of circulating tumor cells (CTCs) are low in lung cancer with approaches due to CTC invasiveness and heterogeneity. In this study, on the basis of the epithelial cell adhesion molecule (EpCAM) phenotype, markers of vimentin and epidermal growth factor receptor (EGFR) phenotype were added to jointly construct a precise and efficient CTC capture system for
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Factors Associated With Precancerous Cervical Lesions in Human Immunodeficiency Virus–Infected Women: A Cross-Sectional Survey in Togo Clin. Med. Insights Oncol. (IF 1.795) Pub Date : 2024-03-20 Tchin Darré, Toukilnan Djiwa, Karell Josiane Ogniadé Ladekpo, Bingo K M’Bortche, Baguilane Douaguibe, Abdoul-Samadou Aboubakari, Didier Koumavi Ekouévi, Bayaki Saka
Background:The burden of human immunodeficiency virus (HIV) in cervical cancer remains a major public health challenge in developing countries, like Togo. Precancerous lesions include all cellular abnormalities that have malignant potential that can develop into cancer. The objective of this study was to determine the prevalence and factors associated with precancerous cervical lesions in HIV-infected
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Identification of Transcriptomic Signatures of Pancreatic Ductal Adenocarcinoma–Derived Exosomes That Promote Macrophage M2 Polarization and Predict Prognosis: S100A9 Reveals Tumor Progression Clin. Med. Insights Oncol. (IF 1.795) Pub Date : 2024-03-20 Siyuan Tan, Haodong Tang, Zheng Zhang, Yang Wang, Haifeng Li, Wenyuan Shi, Hao Ye, Peng Xie, Jiahua Zhou
Background:Exosomes play a role in intercellular communication and participate in the interaction between pancreatic ductal adenocarcinoma (PDAC) cells and immune cells. Macrophages can receive tumor cell–derived exosomes to polarize into M2-type macrophages, which can enhance the invasion and metastasis of pancreatic cancer, leading to poor prognosis. However, the mechanism by which pancreatic cancer
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Role of Oxaliplatin in the Neoadjuvant Concurrent Chemoradiotherapy in Locally Advanced Rectal Cancer: a Review of Evidence Clin. Med. Insights Oncol. (IF 1.795) Pub Date : 2024-03-20 Reza Nazari, Guglielmo Niccolò Piozzi, Reza Ghalehtaki, Seyed Mohsen Ahmadi-Tafti, Behnam Behboudi, Nima Mousavi Darzikolaee, Mahdi Aghili, Maria Antonietta Gambacorta
The treatment of locally advanced rectal cancer (LARC) is a challenging situation for radiation oncologists and colorectal surgeons. Most current approaches recommend neoadjuvant fluorouracil or capecitabine-based chemoradiotherapy followed by surgery as a standard of care. Intensification of concurrent chemotherapy by adding oxaliplatin to fluorouracil or capecitabine backbone to get better outcomes
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Surgical Complications in Papillary Thyroid Cancer Patients with Cervical Lymph Node Metastases Clin. Med. Insights Oncol. (IF 1.795) Pub Date : 2024-03-13 Minh-Chien Pham, Thang Nguyen, Hong-Phong Nguyen
Background:The reported complication rates of neck dissection are not specific patients with papillary thyroid cancer` with metastatic lymph nodes. This study aimed to describe the complication profile of neck dissection and the effect of concurrent lateral neck dissection on complication rates.Methods:This single-center prospective cohort study analyzed the data of 52 patients who underwent a total
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Smoking as a Risk Factor for Very Late Recurrence in Surgically Resected Early-Stage Primary Hepatocellular Carcinoma Clin. Med. Insights Oncol. (IF 1.795) Pub Date : 2024-03-06 Wei-Ru Cho, Chih-Chi Wang, Mu-Jung Tsai, Chih-Che Lin, Yi-Hao Yen, Chien Hung Chen, Yuan-Hung Kuo, Chih-Chien Yao, Chao-Hung Hung, Pao-Yuan Huang, An-Che Liu, Ming-Chao Tsai
Background:The risk of first recurrence of hepatocellular carcinoma (HCC) within years 5 to 10 after curative hepatectomy remains unknown. We aimed to assess the incidence and prognostic factors for very late recurrence among patients who achieved 5 years’ recurrence-free survival (RFS) after primary resection.Methods:We retrospectively analyzed 337 patients with early-stage HCC underwent primary tumor
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Prognostic Significance of the Cachexia Index in Patients with Non-Small-Cell Lung Cancer and Brain Metastases after Stereotactic Radiotherapy Clin. Med. Insights Oncol. (IF 1.795) Pub Date : 2024-03-04 Hui Xu, Bin Zhang, Yongqian Zhang, Chunchun Yang, Changwen Bo, Yuanyuan Guo, Yuan Cheng, Li He
Background:The cachexia index (CXI) has been proposed as a novel biomarker of cancer cachexia. We aimed to investigate the association between CXI and survival outcomes after stereotactic radiotherapy (SRT) in patients with non-small cell lung cancer (NSCLC) and brain metastases.Methods:Data from 145 patients with NSCLC, who underwent SRT for brain metastases between April 2016 and August 2020, were
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Association Between Multiple Single Nucleotide Polymorphisms in Folate Metabolism Pathway and Breast Cancer Risk in Georgian Women: A Case-Control Study Clin. Med. Insights Oncol. (IF 1.795) Pub Date : 2024-03-01 Saba Ahmadi, Sandro Surmava, Davit Kvaratskhelia, Ana Gogolashvili, Eka Kvaratskhelia, Elene Abzianidze, Ketevani Kankava
Background:The folate metabolism pathway plays an integral part in DNA synthesis, methylation, and repair. Methylenetetrahydrofolate reductase (MTHFR) and methylenetetrahydrofolate dehydrogenase (MTHFD1) are both enzymes that are involved in this pathway, and the single nucleotide polymorphisms (SNPs) in genes coding for them have modulatory effects on DNA expression. This study aimed to investigate
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Breast Cancer in Young Women: Is It Different? A Single-Center Retrospective Cohort Study Clin. Med. Insights Oncol. (IF 1.795) Pub Date : 2024-02-20 Omalkhair Abulkhair, Ahmad Omair, Dorothy Makanjuola, Manal Al Zaid, Lolwah Al Riyees, Nafisa Abdelhafiez, Emad Masuadi, Ghaida Alamri, Fatinah Althan, Abdulmohsen Alkushi, Ann Partridge
Introduction:Breast cancer (BC) is one of the commonest cancers among women worldwide. Differences regarding tumor biology, presentation, genetics, and molecular subtypes may contribute to the relatively poorer prognosis among younger women. Limited information exists regarding pathologic characteristics and long-term outcomes among this group.Methods:This retrospective cohort study included 695 BC
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Excellent Bowel Preparation Quality Is Not Superior to Good Bowel Preparation Quality for Improving Adenoma/Polyp Detection Rate Clin. Med. Insights Oncol. (IF 1.795) Pub Date : 2024-02-08 Yingchao Li, Fanjun Meng, Rongrong Cao, Cong Gao, Dongshuai Su, Ke Wang, Jie Han, Xingshun Qi
Background:Adequate bowel preparation quality is essential for high-quality colonoscopy according to the current guidelines. However, the effect of excellent bowel preparation on adenoma/polyp detection rate (ADR/PDR) remained controversial.Methods:During the period from December 2020 to August 2022, a total of 1566 consecutive patients underwent colonoscopy by an endoscopist. Their medical records
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Risk Models for Predicting the Recurrence and Survival in Patients With Hepatocellular Carcinoma Undergoing Radio-Frequency Ablation Clin. Med. Insights Oncol. (IF 1.795) Pub Date : 2024-02-08 Jilin Yang, Lifeng Cui, Wenjian Zhang, Zexin Yin, Shiyun Bao, Liping Liu
Background:Hepatocellular carcinoma (HCC) patients have a poor prognosis after radio-frequency ablation (RFA), and investigating the risk factors affecting RFA and establishing predictive models are important for improving the prognosis of HCC patients.Methods:Patients with HCC undergoing RFA in Shenzhen People’s Hospital between January 2011 and December 2021 were included in this study. Using the
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The Utility of 18F-FDG-PET–CT Metabolic Parameters in Evaluating the Primary Tumor Aggressiveness and Lymph Node Metastasis of Nasopharyngeal Carcinoma Clin. Med. Insights Oncol. (IF 1.795) Pub Date : 2024-02-05 Yun Zhang, Yuxiao Hu, Shuang Zhao, Rong Huang
Background:Following changes in primary tumor (T) and lymph node (N) staging for nasopharyngeal carcinoma (NPC) in the Eighth Edition AJCC Cancer Staging Manual, simplification of T staging has been proposed. However, a limited range of 2-deoxy-2-[fluorine-18] fluoro-D-glucose positron emission tomography–computed tomography (18F-FDG PET–CT) metabolic parameters has been investigated. Therefore, we
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Peripheral Blood CD8+ CD28+ T Cells as an Independent Predictor of Treatment Response and Survival After Concurrent Chemoradiotherapy in Pediatric High-Grade Glioma Patients Clin. Med. Insights Oncol. (IF 1.795) Pub Date : 2024-02-05 Shuo Wang, Xiaofeng Mu, Xiaoli Wang, Li Chen, Changyu Lu, Linan Song
Backgroud:The tumor immune microenvironment influences the efficiency of concurrent chemoradiotherapy (CCRT) in high-grade glioma (HGG). This study investigated peripheral blood T lymphocyte subsets as clinical indicators of therapeutic response and prognosis in pediatric high-grade glioma (pHGG).Methods:This retrospective study included 77 patients with postoperative pHGG who were treated concurrently
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The Implication of Growth Arrest-Specific 5 rs145204276 Polymorphism and Serum Expression of Sirtuin 1, Transforming Growth Factor-Beta, and microRNA-182 in Breast Cancer Clin. Med. Insights Oncol. (IF 1.795) Pub Date : 2024-02-05 Nabil A Hasona, Mahmoud Elsabahy, Olfat G Shaker, Othman Zaki, Ghada Ayeldeen
Background:Breast cancer (BC) patients have a higher chance of survival if it is diagnosed at an early stage, which is essential for efficient treatment of the condition. The results of an elevated risk of cancer, including BC, previously associated with the ins/del polymorphism rs145204276 in the promoter region of growth arrest-specific 5 (GAS5) are still up for debate. Thus, this study aimed to
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Risk Factors for Distant Metastasis in T3 T4 Rectal Cancer Clin. Med. Insights Oncol. (IF 1.795) Pub Date : 2024-02-05 Cui Tang, Jinming Xu, Moubin Lin, Shixiong Qiu, Huan Wang, Xiaoming Zuo, Mengxiao Liu, Peijun Wang
Background:Distant metastasis is the leading cause of death in patients with rectal cancer. This study aims to comprehensively analyze the risk factors of distant metastasis in T3 T4 rectal cancer using magnetic resonance imaging (MRI), pathological features, and serum indicators.Methods:The clinicopathological data of 146 cases of T3 T4 rectal cancer after radical resection from January 2015 to March
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Exosomes in Cancer: Diagnostic and Therapeutic Applications Clin. Med. Insights Oncol. (IF 1.795) Pub Date : 2024-01-20 Quratulain Maqsood, Aleena Sumrin, Yasar Saleem, Abdul Wajid, Muhammada Mahnoor
Small extracellular vesicles called exosomes are produced by cells and contain a range of biomolecules, including proteins, lipids, and nucleic acids. Exosomes have been implicated in the development and spread of cancer, and recent studies have shown that their contents may be exploited as biomarkers for early detection and ongoing surveillance of the disease. In this review article, we summarize
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Artificial Intelligence Applications in the Treatment of Colorectal Cancer: A Narrative Review Clin. Med. Insights Oncol. (IF 1.795) Pub Date : 2024-01-06 Jiaqing Yang, Jing Huang, Deqian Han, Xuelei Ma
Colorectal cancer is the third most prevalent cancer worldwide, and its treatment has been a demanding clinical problem. Beyond traditional surgical therapy and chemotherapy, newly revealed molecular mechanisms diversify therapeutic approaches for colorectal cancer. However, the selection of personalized treatment among multiple treatment options has become another challenge in the era of precision
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Predictors of Myelosuppression for Patients with Head and Neck Squamous Cell Carcinoma After Induction Chemotherapy Clin. Med. Insights Oncol. (IF 1.795) Pub Date : 2024-01-06 Wen-qing Chen, Liang Peng, Xue-lan Zeng, Wei-ping Wen, Wei Sun
Background:Induction chemotherapy (ICT) has become an initial treatment for head and neck squamous cell carcinoma (HNSCC). However, myelosuppression, an unavoidable side effect of ICT, significantly impacts follow-up treatment and prognosis. The main objective of this study is to identify the risk factors and predictors of myelosuppression and its different severity after ICT for ICT.Methods:We retrospectively
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Copper Chaperone for Superoxide Dismutase Subtypes as a Prognostic Marker in Luminal B Breast Cancer Clin. Med. Insights Oncol. (IF 1.795) Pub Date : 2024-01-05 Yanping Li, Wenfei Du, Rui Yang, Xiaonan Wei, Haibin Li, Xiaoyuan Zhang
Background:Copper chaperone for superoxide dismutase ( CCS) is an essential component of the oxidation-reduction system. In breast cancer cells, CCS expression is highly up-regulated, which contributes to cellular proliferation and migration. Breast cancer is a multifaceted disease with different tumor prognoses and responses to clinical treatments, which may be associated with multiple molecular subtypes
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Clinical Pathological Characteristics and Prognosis of Multigene Co-Mutations in Elderly Patients With Non-Small Cell Lung Cancer: A Retrospective Analysis. Clin. Med. Insights Oncol. (IF 1.795) Pub Date : 2023-11-29 Wanjing Li,Fangqun Chang,Hao Zhang,Furong Meng,Zhangyan Ke,Yanbei Zhang
Background With the development and wide application of next-generation sequencing (NGS), multiple-gene mutations related to lung cancer are detected using this technology. Notably, even multigene concomitant mutations (co-mutations), which occur at a relatively low incidence, can be detected more effectively using NGS. It is well-known that the percentages of non-small cell lung cancer (NSCLC) in
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Circadian Clock Dysregulation and Prostate Cancer: A Molecular and Clinical Overview. Clin. Med. Insights Oncol. (IF 1.795) Pub Date : 2023-11-27 Dalia Kaakour,Bridget Fortin,Selma Masri,Arash Rezazadeh
Circadian clock dysregulation has been implicated in various types of cancer and represents an area of growing research. However, the role of the circadian clock in prostate cancer has been relatively unexplored. This literature review will highlight the potential role of circadian clock dysregulation in prostate cancer by examining molecular, epidemiologic, and clinical data. The influence of melatonin
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Clinicopathologic Features and Prognosis of Female Early Breast Cancer With HER2 Low Expression: A Propensity Score Matched Analysis. Clin. Med. Insights Oncol. (IF 1.795) Pub Date : 2023-11-24 Lanyi Dai,Qiyuan Huang,Rong Guo,Keying Zhu,Yiyin Tang,Dedian Chen,Sheng Huang
Background Metastatic breast cancer (MBC) patients with low expression of human epidermal growth factor 2 (HER2) have been proven to benefit from HER2 targeted therapy. We aimed to determine how HER2-low status affected survival and metastatic risk as well as how it affected pathological complete response (pCR) in neoadjuvant chemotherapy (NAC) patients. Methods According to the results of immunohistochemistry
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"Fast First and Then Slowly" Steroid-Tapering Regimen in Managing Corticoid-Sensitive Patients With Severe Immunotherapy Complications After Anti-PD-(L)1 Therapy for Cancer. Clin. Med. Insights Oncol. (IF 1.795) Pub Date : 2023-11-24 Qi Gui,Liping Xie,Shaoqi Cheng,Chengcheng Xu
Background We aimed to assess the efficacy of the "fast first and then slowly" steroid-tapering regimen used in managing corticoid-sensitive patients with severe irAE after anti-PD-(L)1 therapy. Corticosteroids are the primary therapy for severe immune-related adverse events (irAEs). Less is known about the standard steroid-tapering regimen for corticoid-sensitive patients. Methods This study was a
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The Antitumor Impact of Combining Hepatic Artery Ligation With Copper Chelators for Liver Cancer. Clin. Med. Insights Oncol. (IF 1.795) Pub Date : 2023-11-22 Ni Zeng,Ye Wang,Yuan Wan,Hongyu Wang,Nan Li
Background Hepatocellular carcinoma (HCC) is one of the main cancer-related mortality worldwide. Thus, there is a constant search for improvement in treatment strategies to enhance the prognosis of this malignancy. The study aims to investigate the combined antitumor activity of ammonium tetrathiomolybdate (TM, copper chelator) combined with hepatic artery ligation (HAL) for liver cancer. Methods A
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Improving Treatment Outcome for Cervical Cancer Using 2-Point Assessment of Quality of Life Among Nigerian Women: A Protocol for a Multi-Center Study. Clin. Med. Insights Oncol. (IF 1.795) Pub Date : 2023-11-14 Maureen Uche Umemmuo,George Uchenna Eleje,Timothy A Oluwasola,Michael Ezeanochie,Hadiza Abdullahi Usman,Jawhara Shehu Galadanci,Chiemezie Mac-Kingsley Agbanu,Ayyuba Rabiu
Background Cervical cancer is the fourth most common cancer among women globally, with quality of life (QOL) being a major concern for patients with cervical cancer, especially in low- and middle-income countries (LMICs). This is largely due to the advanced nature of the disease at presentation. Although there are a higher number of studies focusing on the QOL of high-income countries, the QOL of cervical
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Contrast-Enhanced MRI in Women with Endometrial Cancer: Dynamic Versus Single-Phase Acquisitions. Clin. Med. Insights Oncol. (IF 1.795) Pub Date : 2023-11-13 Myoung Seok Lee,Min Hoan Moon,Taek Min Kim,Siwon Jang,Sohee Oh,Jeong Yeon Cho
Background The 2019 European Society of Urogenital Radiology (ESUR) guidelines for endometrial cancer recommend performing either dynamic contrast-enhanced magnetic resonance imaging (CE MRI) or single-phase CE MRI. However, no study has directly compared these options. Therefore, this study compared dynamic versus single-phase CE MRI for the evaluation of myometrial invasion in women with endometrial
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Is the Urinary and Gut Microbiome Associated With Bladder Cancer? Clin. Med. Insights Oncol. (IF 1.795) Pub Date : 2023-11-13 Joanna Chorbińska,Wojciech Krajewski,Łukasz Nowak,Klaudia Bardowska,Paulina Żebrowska-Różańska,Łukasz Łaczmański,Katarzyna Pacyga-Prus,Sabina Górska,Bartosz Małkiewicz,Tomasz Szydełko
Background Microbiome dysbiosis plays a role in the pathogenesis of many urological diseases, including bladder cancer (BC). The aim of the study was to compare the urinary and gut microbiota of patients with BC with a healthy control (HC) group. Methods The study group included patients hospitalized in 2020 to 2021 with diagnosed BC and HC. Prior to the transurethral resection of bladder tumor, patients
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A Systematic Review of Clinical Practice Guidelines for Managing Pulmonary Toxicities Caused by Immune Checkpoint Inhibitors: Quality of Treatment Recommendations and Differences in Management Strategies Between Guidelines. Clin. Med. Insights Oncol. (IF 1.795) Pub Date : 2023-11-08 Kofi N Donkor,Hyeree Jang,Reena Sail
Background Pulmonary toxicities caused by immune checkpoint inhibitors are a prominent concern for clinicians. Clinical Practice Guidelines (CPGs) are critical for managing these toxicities. Methods A systematic search of CPGs on checkpoint-associated pulmonary toxicities (ca-PT) was conducted in October 2022. PubMed, Embase, Cochrane Library, CINAHL, and Web of Science were searched. AGREE II and
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The Investigation of the Association Between the Bcl-2 3'-UTR rs1564483 Polymorphism and miR-296-3p in the Development of Breast and Gastric Cancers. Clin. Med. Insights Oncol. (IF 1.795) Pub Date : 2023-11-03 Mehrnoush Azadeh Jouneghani,Fatemeh Keshavarzi,Nahid Haghnazari,Zahra Hooshmandi,Sabrieh Amini
Background B-cell leukemia/lymphoma 2 (Bcl-2) gene regulates carcinogenesis by inhibiting apoptosis. This study evaluated the association of Bcl-2 3'-untranslated regions (3' UTR) rs1564483 polymorphism and miR-296-3p with the development of breast and gastric cancers. Methods A microarray analysis was performed on the Genomic Spatial Event (GSE)29431 and GSE161533 datasets for breast and gastric cancers
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Comparison of Sentinel Lymph Node Biopsy by Blue Dye Conjunction With Indocyanine Green or Radioisotope in Early-Stage Breast Cancer: A Prospective Single-Center Observational Study. Clin. Med. Insights Oncol. (IF 1.795) Pub Date : 2023-11-01 Yanmei Wang,Qing Peng,Pengcheng Sun,Xuesha Li,Yilong Dong
Background Although radioisotope (RI) combined with blue dye (BD) is the standard technique for sentinel lymph node (SLN) biopsy in breast cancer, the use of RI is limited at some institutions due to the specific equipment needed. Indocyanine green (ICG) fluorescence detection has been developed as a potential substitute for RI method. However, reports on the sensitivity of ICG and RI techniques in
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The Riddle of the Sphinx: Progress in Leptomeningeal Metastasis of Non-Small Cell Lung Cancer. Clin. Med. Insights Oncol. (IF 1.795) Pub Date : 2023-10-30 Yuhua Zhao,Limeng Yu,Lili Wang,Yingxi Wu,Haiyang Chen,Qiming Wang,Yufeng Wu
Leptomeningeal metastasis (LM) is a serious complication of advanced non-small cell lung cancer (NSCLC), and the incidence of LM has been increasing yearly in recent times. There is no consensus on the best treatment modality for LM, which underscores a difficult problem in the management of advanced NSCLC patients. The existing treatments include molecular targeted therapy, systemic chemotherapy,
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Clinical Features and Outcomes of Primary Breast Diffuse Large B-Cell Lymphoma: A Matched-Pair Study. Clin. Med. Insights Oncol. (IF 1.795) Pub Date : 2023-10-28 Ling-Chiao Teng,Yu-Min Liao,Jyh-Pyng Gau,Tzu-Hung Hsiao,Tsung-Chih Chen,Mei-Hui Chen,Su-Peng Yeh,Chieh-Lin Jerry Teng
Background The influence of the breast as the primary site on the outcome of diffuse large B-cell lymphoma (DLBCL) and further changes in therapeutic strategies remain unclear. We aimed to compare the outcomes between primary breast and non-breast DLBCL and analyze the genetic profiles of some of the study cohorts using next-generation sequencing. Methods This matched-pair study reviewed the medical
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Relationships of BRAF V600E Gene Mutation With Some Immunohistochemical Markers and Recurrence Rate in Patients With Thyroid Carcinoma. Clin. Med. Insights Oncol. (IF 1.795) Pub Date : 2023-10-28 Tri Bui Dang Minh,Thuan Nghiem Duc,Van Phan Nguyen Thanh,Tuan Dinh Le,Minh Duc Tong,Trung Hoang Nguyen,Anh Le Tuan,Kien Xuan Nguyen,Tien Tran Viet,Thang Ba Ta,Son Tien Nguyen,Hai Anh Vu,Ba Van Nguyen,Dung Nguyen Thi Ngoc,Viet Tran Quoc,Thanh Bui Duc
Background The B-type rafkinase (BRAF) V600E gene mutation plays an important role in the pathogenesis, diagnosis, and prognosis of thyroid carcinoma. This study was conducted to investigate the rate of the BRAF V600E mutation, the relationships between the BRAF V600E gene mutation and some immunohistochemical markers, and recurrence rate in patients with differentiated thyroid cancer. Method The study
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The RNA m6A-Binding Protein YTHDC1 Is Downregulated and Associated With M2 Macrophage Infiltration in Muscle-Invasive Bladder Cancer. Clin. Med. Insights Oncol. (IF 1.795) Pub Date : 2023-10-26 Lamei Zhao,Dongyan Han,Jianghua Zhu,Dexi Bi,Tingting Ding,Xingchen Zhu,Dengfeng Huang,Youhua Zhang,Ling Lu,Weijun Wu,Yaohui Gao,Hu Liu,Qiongyi Huang,Qing Wei,Xudong Yao
Background Dysregulation of RNA N6-methyladenosine (m6A) modification is indispensable in tumorigenesis. However, in muscle-invasive bladder cancer (MIBC), the key regulators and mechanisms involved in this process remain largely unknown. This study aimed to screen the key m6A regulators and explore its possible role in MIBC. Methods Aberrantly expressed m6A regulator genes were screened in The Cancer
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Evaluating the Role of Morphological Parameters in the Prostate Transition Zone in PHI-Based Predictive Models for Detecting Gray Zone Prostate Cancer. Clin. Med. Insights Oncol. (IF 1.795) Pub Date : 2023-10-19 Yu-Hang Qian,Yun-Tian Shi,Xu-Jun Sheng,Hai-Hong Liao,Hao-Jie Chen,Bo-Wen Shi,Yong-Jiang Yu
Background The early detection of clinically significant prostate cancer (csPCa) through the integration of multidimensional parameters presents a promising avenue for improving survival outcomes for this fatal disease. This study aimed to assess the contribution of prostate transition zone (TZ) to predictive models based on the prostate health index (PHI), with the goal of enhancing early detection
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Optimal Cutoff Values of the Contact Angle of Tumor on Sonography System for Predicting Extrathyroidal Extension of Papillary Thyroid Carcinoma by Tumor Location. Clin. Med. Insights Oncol. (IF 1.795) Pub Date : 2023-10-16 Ik Beom Shin,Do Hoon Koo,Dong Sik Bae
Background Extrathyroidal extension (ETE) significantly affects the treatment strategy for thyroid cancer. We present a new method to predict ETE of papillary thyroid carcinoma (PTC). methods We enrolled 1 481 patients with PTCs. The ETE was classified into minimal and gross ETE. Using the novel "contact angle of the tumor on sonography" (CATS) system, we calculated optimal cutoffs for predicting ETE
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Association Between Polymorphism in Diabetes Susceptibility Gene Insulin-Like Growth Factor 2mRNA-Binding Protein 2 and Risk of Diffuse Large B-Cell Lymphoma. Clin. Med. Insights Oncol. (IF 1.795) Pub Date : 2023-10-09 Weiling Zhou,Qian Gao,Cuiying He,Lianjing Wang,Yuan Wang,Lei Feng,Weijing Li,Wei Liu,Ruijuan Ma,Lihong Liu
Background Numerous studies have shown that polymorphisms in the diabetes susceptibility gene, insulin-like growth factor 2mRNA-binding protein 2 (IGF2BP2), are associated with the occurrence and development of various malignant tumors; however, their correlation with the onset of diffuse large B-cell lymphoma (DLBCL) is still unknown. Therefore, this study aimed to explore whether IGF2BP2 polymorphisms
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Correlation Analysis of the TP53 Mutation With Clinical Characteristics in the Prognosis of Non-Small Cell Lung Cancer. Clin. Med. Insights Oncol. (IF 1.795) Pub Date : 2023-10-09 Lihuan Zhu,Dongsheng Zhou,Yiyong Chen,Tianxing Guo,Wenshu Chen,Xiaojie Pan
Background Non-small cell lung cancer (NSCLC) with TP53 mutations has a worse prognosis. It was generally more resistant to chemotherapy and radiation. Our aim was to investigate the correlation between the TP53 co-mutated gene and clinical features, and prognostic value in patients with NSCLC. Methods Seventy-three patients with a diagnosis of NSCLC at our hospital were recruited. They were divided
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SPAG5 Expression Predicts Poor Prognosis and is Associated With Adverse Immune Infiltration in Lung Adenocarcinomas. Clin. Med. Insights Oncol. (IF 1.795) Pub Date : 2023-09-22 Gang Xiao,Xie Xu,Zhibo Chen,Jie Zeng,Jianjiang Xie
Background Sperm-associated antigen 5 (SPAG5) has been identified as a novel driver oncogene involved in multiple cancers; however, its role in lung adenocarcinoma (LUAD) needs further investigation. Our study aims to elucidate the potential significance of SPAG5 in LUAD prognosis and its implications for the efficacy of immunotherapy. Methods In this study, we used bioinformatics analysis and tissue
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Monocyte-to-High-Density Lipoprotein Cholesterol Ratio Together With the Lymphocyte-to-Monocyte Ratio in Predicting the Malignancy of the Thyroid Nodule in Patients Complicated With Type 2 Diabetes. Clin. Med. Insights Oncol. (IF 1.795) Pub Date : 2023-09-21 Yingying Hu,Yanyan Shen,Erjie Xia,Suzita Hirachan,Adheesh Bhandari,Zao Jin
Background Thyroid nodules, although mostly benign and symptomless, have a small chance of being cancerous, necessitating accurate diagnosis. This study aims to develop and validate a nomogram for differentiating malignant and non-malignant thyroid nodules in individuals with type 2 diabetes. Methods The study included 484 patients with both thyroid nodules and type 2 diabetes who underwent thyroid
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The Value of Neoadjuvant Anthracycline-Based Regimens for HER2-Positive Breast Cancer: A Systematic Review and Meta-analysis Including 1366 Patients. Clin. Med. Insights Oncol. (IF 1.795) Pub Date : 2023-09-21 Yuqin Ding,Kaijing Ding,Xiangming He,Wenju Mo,Chenlu Liang,Lijie Gong,Yuting Huang,Xiaowen Ding
Background The standard recommendation for neoadjuvant therapy for human epidermal growth factor receptor-2 (HER2)-positive breast cancer patients is trastuzumab in combination with chemotherapy, but there is no current standard recommendation for appropriate chemotherapy regimens. This meta-analysis evaluated the efficacy and cardiac safety of the concurrent use of anti-HER2 targeted drugs and anthracycline-based
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Comparing Tribbles Homolog 3 (TRIB3) Protein Expression Levels with Clinicopathological Characteristics and Survival Among Neuroblastoma Patients. Clin. Med. Insights Oncol. (IF 1.795) Pub Date : 2023-09-19 Burçin Baran,Gamze Sanlav,Deniz Kızmazoğlu,Selen Kum Özşengezer,Safiye Aktaş,Zekiye Altun,Nur Olgun
Background Tribbles Homolog 3 (TRIB3) is a member of the pseudokinase family of tribbles and acts as an adaptor protein to regulate different cellular processes. Upregulation of TRIB3 expression was shown either as a favorable or an adverse prognostic factor in various adult malignancies. However, TRIB3 expression has not been examined in pediatric cancers. Neuroblastoma is the most common malignant
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Potential Ability of Probiotics in the Prevention and Treatment of Colorectal Cancer. Clin. Med. Insights Oncol. (IF 1.795) Pub Date : 2023-08-17 Jiahao Zhao,Yiqun Liao,Chen Wei,Yichao Ma,Fei Wang,Yuji Chen,Bin Zhao,Hao Ji,Daorong Wang,Dong Tang
Colorectal cancer (CRC) is the third most common cancer in the world, and its incidence rate and mortality are on the rise in many countries. In recent years, with the improvement of economic conditions, people's living habits have changed, including lack of physical activity, poor diet patterns and circadian rhythm disorder. These risk factors can change the colon environment and the composition of
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Mirvetuximab Soravtansine in Platinum-Resistant Ovarian Cancer. Clin. Med. Insights Oncol. (IF 1.795) Pub Date : 2023-07-25 Eduardo Gonzalez-Ochoa,Ana C Veneziani,Amit M Oza
Ovarian cancer is the second leading cause of death from gynecologic malignancies worldwide. Management of platinum-resistant disease is challenging and clinical outcomes with standard chemotherapy are poor. Over the past decades, significant efforts have been made to understand drug resistance and develop strategies to overcome treatment failure. Antibody drug conjugates (ADCs) are a rapidly growing
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Pleural Mesothelioma in the Era of Immunotherapy. Clin. Med. Insights Oncol. (IF 1.795) Pub Date : 2023-07-20 Mathieu Chevallier,Floryane Kim,Alex Friedlaender,Alfredo Addeo
Over the course of the last decade, immunotherapy has revolutionised the management of a great number of cancer types. The treatment of pleural mesothelioma, a rare and highly aggressive cancer, is also being transformed by immunotherapy. The recent combination of ipilimumab and nivolumab improved overall survival compared with platinum-based chemotherapy, irrespective of the histology, establishing
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Comparison of Acute Hematological Adverse Reactions Induced by Craniospinal Irradiation With Intensity-Modulated Radiotherapy and Conventional Radiotherapy. Clin. Med. Insights Oncol. (IF 1.795) Pub Date : 2023-07-18 Jie Chen,Zhichao Fu,Yunyun Zhu
Background With the update of equipment, the hospital base of this study began to adopt craniospinal irradiation (CSI) intensity-modulated radiotherapy (IMRT) in May 2018 to replace the traditional CSI conventional radiotherapy (CRT) technology. The purpose of this study was designed to compare the differences in acute hematological adverse reactions induced by CSI-IMRT and CSI-CRT. Methods The clinical
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The Genomic and Proteomic Profiles of NTRK Genes and Trk Receptors in Liver Hepatocellular Carcinoma. Clin. Med. Insights Oncol. (IF 1.795) Pub Date : 2023-07-10 Hejing Wang,Lina Qi,Chenhan Zhong,Xuefeng Fang,Ying Yuan
Background The neurotrophic tyrosine kinase (NTRK) gene family includes NTRK1, NTRK2, and NTRK3, which encode tropomyosin receptor kinases TrkA, TrkB, and TrkC, respectively. This study aimed to initially assess the genomic and proteomic profiles of NTRK genes and Trk receptors in liver hepatocellular carcinoma (LIHC). Methods The ONCOMINE, UALCAN, GEPIA, cBioPortal, FusionGDB, SurvivalMeth, and the
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A Retrospective Analysis of Denosumab for the Treatment of Bone Metastases in Chinese Patients With Breast Cancer. Clin. Med. Insights Oncol. (IF 1.795) Pub Date : 2023-07-10 Wei Li,Xinyu Wu,Heng Yu,Zekai Zhu,Wenjie Li,Xiang Huang
Background Denosumab entered the Chinese market for the first time in 2020. Since it is a short period of time, there is a lack of data on its effectiveness and safety in Chinese people. The objective of this study was to evaluate the effectiveness and safety of denosumab in delaying skeletal-related events (SREs) in patients with breast cancer metastatic to bone. Methods The study retrospectively
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Evaluating the Effectiveness of Intravesical Instillation of BCG by Modified Maintenance Method in Patients With High-Risk Ta and T1 Bladder Cancer: A Randomized Clinical Trial. Clin. Med. Insights Oncol. (IF 1.795) Pub Date : 2023-07-08 Nasser Shakhssalim,Mehdi Dadpour,Farzaneh Sharifiaghdas,Behzad Narouie,Sajjad Askarpour Kabir,Ehsan Sepehran,Ramin Borabadi,Nasrin Borumandnia,Hamidreza Rouientan,Abbas Basiri
Background It is estimated that 75% of urothelial bladder cancers are non-muscle-invasive cancers (NMIBCs). The development of more effective methods for optimizing the management of this subset of patients is of paramount importance. This study aimed to evaluate the effectiveness and side effects of modified maintenance Bacillus Calmette-Guérin (BCG) therapy in patients with high-risk NMIBC. Methods
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Anlotinib as Monotherapy or Combination Therapy for Recurrent High-Grade Glioma: A Retrospective Study. Clin. Med. Insights Oncol. (IF 1.795) Pub Date : 2023-07-06 Jun Yin,Wenya Yin,Linlin Zheng,Yimin Li,Cheng Luo,Shuo Zhang,Lei Duan,Hang Zhou,Kai Cheng,Jinyi Lang,Ke Xu
Background Anlotinib is a multi-target anti-angiogenic agent. The retrospective study was conducted to evaluate the safety and effectiveness of anlotinib as monotherapy or combination therapy for the treatment of recurrent high-grade gliomas. Methods In this retrospective study, patients with recurrent high-grade glioma (according to the 2021 World Health Organization classification as levels III-IV)
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VEGF Mediates Tumor Growth and Metastasis by Affecting the Expression of E-Cadherin and N-Cadherin Promoting Epithelial to Mesenchymal Transition in Gastric Cancer. Clin. Med. Insights Oncol. (IF 1.795) Pub Date : 2023-07-06 Yue Zhang,Yanyan Wang,Menglin Zhao,Xinwei Li,Huiyuan Li,Mingyue Tang,Zhijun Geng,Lugen Zuo,Xue Song,Zishu Wang,Qiang Wang,Fang Su
Background Gastric cancer (GC) is the fifth leading cancer in the world, and there is a high mortality rate in China. Exploring the relationship between the prognosis of GC and the expression of related genes is helpful to further understand the common characteristics of the occurrence and development of GC and provide a new method for the identification of early GC, so as to provide the best therapeutic
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Fucosyltransferase 5 Promotes the Proliferative and Migratory Properties of Intrahepatic Cholangiocarcinoma Cells via Regulating Protein Glycosylation Profiles. Clin. Med. Insights Oncol. (IF 1.795) Pub Date : 2023-07-04 Jingheng Guo,Qian Cheng,Yongjian Li,Lingyu Tian,Delin Ma,Zhao Li,Jie Gao,Jiye Zhu
Background The incidence of intrahepatic cholangiocarcinoma (ICC) is increasing globally, and its prognosis has not improved substantially in recent years. Understanding the pathogenesis of ICC may provide a theoretical basis for its treatment. In this study, we investigated the effects and underlying mechanisms of fucosyltransferase 5 (FUT5) on the malignant progression of ICC. Methods FUT5 expression
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Stratification of Risk Factors of Lung Cancer-Associated Venous Thromboembolism and Determining the Critical Point for Preemptive Intervention: A Systematic Review With Meta-analysis. Clin. Med. Insights Oncol. (IF 1.795) Pub Date : 2023-06-28 Theresa Nwagha,Martins Nweke
Background Several biomarkers or risk factors have been identified and several prediction models exist. The major limitations inherent in these models include cost-ineffectiveness and lack of systematic stratification of risk factors resulting in the inclusion of clinically insignificant biomarkers in the models. This review aimed to systematically stratify the risk factors of lung cancer-associated