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Identification of common mechanisms and biomarkers of atrial fibrillation and heart failure based on machine learning Esc Heart Fail. (IF 3.8) Pub Date : 2024-04-24 Zhijun Zhang, Jianying Ding, Xiaolong Mi, Yuanyuan Lin, Xinjian Li, Jun Lian, Jinwen Liu, Lijuan Qu, Bingye Zhao, Xuewen Li
AimsAtrial fibrillation (AF) is the most common arrhythmia. Heart failure (HF) is a disease caused by heart dysfunction. The prevalence of AF and HF were progressively increasing over time. The co‐existence of AF and HF presents a significant therapeutic challenge. In order to provide new ideas for the diagnosis of AF and HF, it is necessary to carry out biomarker related studies.Methods and resultsThe
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Apixaban in bridge to transplant and destination LVAD ‐ rationale and study design: the ApixiVAD trial Esc Heart Fail. (IF 3.8) Pub Date : 2024-04-23 Bruno Schnegg, Ricardo Deveza, Christopher Hayward
AimsUse of novel anticoagulation in mechanical circulatory support is controversial. We report the rationale and design of the ApixiVad pilot trial, a pilot study testing the safety of apixaban as an anticoagulant in patients bridged to transplant (BTT) or for destination (DT) with Heartmate 3 (HM3) left ventricular assist device (LVAD).Methods and resultsApixaban has been used in small non‐randomized
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The effect of sodium‐glucose co‐transporter 2 inhibitors on outcomes after cardiac resynchronization therapy Esc Heart Fail. (IF 3.8) Pub Date : 2024-04-23 Jonathan J.H. Bray, Marco Coronelli, Sam G.C. Scott, John A. Henry, Liam S. Couch, Mahmood Ahmad, Julian Ormerod, James Gamble, Timothy R. Betts, Andrew Lewis, Oliver J. Rider, Peregrine G. Green, Neil Herring
AimsThe trials upon which recommendations for the use of cardiac resynchronization therapy (CRT) in heart failure used optimal medical therapy (OMT) before sodium‐glucose co‐transporter 2 inhibitors (SGLT2i). Moreover, the SGLT2i heart failure trials included only a small proportion of participants with CRT, and therefore, it remains uncertain whether SGLT2i should be considered part of OMT prior to
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Haemodynamic implications of VA‐ECMO vs. VA‐ECMO plus Impella CP for cardiogenic shock in a large animal model Esc Heart Fail. (IF 3.8) Pub Date : 2024-04-23 Peter H. Frederiksen, Louise Linde, Emilie Gregers, Nanna L.J. Udesen, Ole K. Helgestad, Ann Banke, Jordi S. Dahl, Lisette O. Jensen, Jens F. Lassen, Amalie L. Povlsen, Jeppe P. Larsen, Henrik Schmidt, Hanne B. Ravn, Jacob E. Møller
AimsVeno‐arterial extracorporeal membrane oxygenation (VA‐ECMO) with profound left ventricular (LV) failure is associated with inadequate LV emptying. To unload the LV, VA‐ECMO can be combined with Impella CP (ECMELLA). We hypothesized that ECMELLA improves cardiac energetics compared with VA‐ECMO in a porcine model of cardiogenic shock (CS).Methods and resultsLand‐race pigs (weight 70 kg) were instrumented
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Prognostic value of growth differentiation factor‐15 in heart failure among whole ejection fraction phenotypes Esc Heart Fail. (IF 3.8) Pub Date : 2024-04-20 Lyu Lyu, Juan Xu, Cui Xv, Hunan Xiao, Zhenzhen Liu, Yanru He, Weiyang Gao, Benchuan Hao, Hongbin Liu
AimsThe utility of growth differentiation factor‐15 (GDF‐15) in predicting long‐term adverse outcomes in heart failure (HF) patients is not well established. This study explored the relationship between GDF‐15 levels and adverse outcomes in HF patients across various ejection fraction (EF) phenotypes associated with coronary heart disease (CHD) and evaluated the added prognostic value of incorporating
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Representativeness of the PIONEER‐HF and PARAGLIDE‐HF in patients hospitalized with acute heart failure Esc Heart Fail. (IF 3.8) Pub Date : 2024-04-19 Dong‐Yi Chen, Chun‐Chi Chen, Cheng‐Hung Lee, Chi‐Nan Tseng, Shao‐Wei Chen, Shang‐Hung Chang, Tien‐Hsing Chen, Pao‐Hsien Chu, I‐Chang Hsieh, Ming‐Shien Wen, Ming‐Lung Tsai, Ming‐Jer Hsieh
AimsThe PIONEER‐HF and PARAGLIDE‐HF trials aimed to determine the efficacy and safety of the in‐hospital initiation of sacubitril/valsartan in patients hospitalized for AHF. However, whether the inclusion and exclusion criteria of the trials apply to patients encountered in real‐world routine care is unclear. This study aimed to investigate the applicability of the PIONEER‐HF and PARAGLIDE‐HF trials
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Circulating miRNA in functional tricuspid regurgitation. Unveiling novel links to heart failure: A pilot study Esc Heart Fail. (IF 3.8) Pub Date : 2024-04-19 Rocio Hinojar, Rafael Moreno‐Gómez‐Toledano, Elisa Conde, Ariana Gonzalez‐Gomez, Ana García‐Martin, Paz González‐Portilla, Covadonga Fernández‐Golfín, Maria Laura García‐Bermejo, Carlos Zaragoza, Jose Luis Zamorano
AimSevere functional tricuspid regurgitation (FTR) is associated with high risk of cardiovascular events, particularly heart failure (HF) and mortality. MicroRNAs (miRNAs) have been recently identified as novel biomarkers in different cardiovascular conditions, but no studies have focused on FTR. We sought to (1) to identify and validate circulating miRNAs as regulators of FTR and (2) to test association
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Exercise limitation in hypertrophic cardiomyopathy: combined stress echocardiography and cardiopulmonary exercise test Esc Heart Fail. (IF 3.8) Pub Date : 2024-04-19 Yonatan Erez, Eihab Ghantous, Aviel Shetrit, Ryan S. Zamanzadeh, David Zahler, Yoav Granot, Orly Ran Sapir, Michal Laufer Perl, Shmuel Banai, Yan Topilsky, Ofer Havakuk
AimsThe study aims to investigate exercise‐limiting factors in hypertrophic cardiomyopathy (HCM) using combined stress echocardiography and cardiopulmonary exercise test.Methods and resultsA symptom‐limited ramp bicycle exercise test was performed in the semi‐supine position on a tilting dedicated ergometer. Echocardiographic images were obtained concurrently with gas exchange measurements along predefined
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Treatment patterns of patients with worsening heart failure with reduced ejection fraction Esc Heart Fail. (IF 3.8) Pub Date : 2024-04-19 Stephen J. Greene, Hanna K. Gaggin, Mo Zhou, Lori D. Bash, Dominik Lautsch, Laurence Djatche, Yan Song, James Signorovitch, Andra S. Stevenson, Robert O. Blaustein, Javed Butler
AimsPatients with HFrEF and worsening HF events (WHFE) are at particularly high risk and urgently need disease‐modifying therapy. CHART‐HF assessed treatment patterns and reasons for medication decisions among HFrEF patients with and without WHFE.Methods and resultsCHART‐HF collected retrospective electronic medical records of outpatients with HF and EF < 45% between 2017–2019 from a nationwide panel
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Predicting in‐hospital mortality among patients admitted with a diagnosis of heart failure: a machine learning approach Esc Heart Fail. (IF 3.8) Pub Date : 2024-04-19 Zina Jawadi, Rosemary He, Pratyaksh K. Srivastava, Gregg C. Fonarow, Suzan O. Khalil, Srikanth Krishnan, Eleazar Eskin, Jeffrey N. Chiang, Ali Nsair
Existing risk prediction models for hospitalized heart failure patients are limited. We identified patients hospitalized with a diagnosis of heart failure between 7 May 2013 and 26 April 2022 from a large academic, quaternary care medical centre (training cohort). Demographics, medical comorbidities, vitals, and labs were collected and were used to construct random forest machine learning models to
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Reply to: “CardioMEMS in HF patients: study confirms benefit in costs and QALYs, but does not measure QALYs” Esc Heart Fail. (IF 3.8) Pub Date : 2024-04-19 Pau Codina, Francesc López‐Seguí, Antoni Bayés‐Genís
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Blunted cardiovascular responses to exercise by inhibiting afferent feedback via spinal cord stimulation in heart failure Esc Heart Fail. (IF 3.8) Pub Date : 2024-04-19 Chul‐Ho Kim, Tim J. Lamer, Manda Keller‐Ross, Craig Stolen, Bruce D. Johnson
This case study investigated the impact of SCS on alterations in blood pressure during constant‐load exercise in a female patient with heart failure. Three different SCS frequencies [No SCS (~0 Hz), Low SCS (~100 Hz), and High SCS (~1000 Hz)] with and without ischaemic stimulation of the legs (cuffs) were randomly applied during constant‐load exercise. To determine cardiovascular and ventilatory responses
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Prediction of cardiac worsening through to cardiogenic shock in patients with acute heart failure Esc Heart Fail. (IF 3.8) Pub Date : 2024-04-18 Benedikt N. Beer, Caroline Kellner, Jonas Sundermeyer, Lisa Besch, Angela Dettling, Paulus Kirchhof, Stefan Blankenberg, Christina Magnussen, Benedikt Schrage
AimsAcute heart failure (AHF) can result in worsening of heart failure (WHF), cardiogenic shock (CS), or death. Risk factors for these adverse outcomes are not well characterized. This study aimed to identify predictors for WHF or new‐onset CS in patients hospitalized for AHF.Methods and resultsProspective cohort study enrolling consecutive patients with AHF admitted to a large tertiary care centre
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Intramyocardial calcification in apical hypertrophic cardiomyopathy assessed using multimodality imaging: a case series Esc Heart Fail. (IF 3.8) Pub Date : 2024-04-18 Ilaria Radano, Barbara Mabritto, Stefania Luceri, Sergio Bongioanni, Francesco Maiellaro, Luca Zappia, Chiara Lario, Annalisa Macera, Stefano Cirillo, Alfredo Pizzuti, Rodolfo Citro, Gennaro Galasso, Giuseppe Musumeci
Apical hypertrophic cardiomyopathy (ApHCM) is an HCM variant, affecting frequently males in midlife. It is characterized by apical obliteration and persistent diastolic contraction, often resulting in microvascular ischaemia. We report five cases of ApHCM, with evidence of intramyocardial calcification on echocardiogram. On cardiac magnetic imaging (MRI), a hypointense component at early gadolinium
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Missed opportunities in heart failure diagnosis and management: study of an urban UK population Esc Heart Fail. (IF 3.8) Pub Date : 2024-04-17 Sylwia Migas, Michelle Louise Ellis, Bozydar Wrona, Elena Rivero Sanz, Jack Brownrigg, Otto Strauss, Fozia Zahir Ahmed
AimsThis study aimed to examine the diagnostic pathways and outcomes of patients with heart failure (HF), stratified by left ventricular ejection fraction (EF), and to highlight deficiencies in real‐world HF diagnosis and management.Methods and resultsWe conducted a retrospective cohort study in Salford, United Kingdom, utilizing linked primary and secondary care data for HF patients diagnosed between
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Oral nutritional supplements in older outpatients with heart failure: rationale and design of the ALIMENT‐HF trial Esc Heart Fail. (IF 3.8) Pub Date : 2024-04-17 Yudai Fujimoto, Taishi Dotare, Emi Maekawa, Kentaro Kamiya, Takeshi Kitai, Koichiro Kuwahara, Teruyasu Sugano, Masaaki Konishi, Tomohito Ohtani, Yoko Sakamoto, Kentaro Jujo, Chiharu Noda, Junya Ako, Naotake Yanagisawa, Yuya Matsue
AimsThe ALIMENT‐HF trial aims to determine whether high‐calorie and high‐protein oral nutritional supplements (ONS) are safe and beneficial for older adult outpatients with heart failure (HF).Methods and resultsThis multicentre, single‐arm, interventional pilot trial is designed to evaluate the tolerance, efficacy, and safety of ONS in older adult outpatients with chronic HF, malnutrition, and anorexia
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Left ventricular reverse remodelling as a promising strategy for resolving left ventricular thrombus Esc Heart Fail. (IF 3.8) Pub Date : 2024-04-17 Xuefu Chen, Xinxin Zhang, Yahui Yang, Yuxi Sun, Jinping Si, Shufen Jiang, Yuze Hu, Zijie Ding, Yunlong Xia, Yanwei Chen, Ying Liu
AimsRecent years, several studies have suggested that abnormal baseline left ventricular (LV) function and structure are associated with left ventricular thrombus (LVT) formation. Despite this, most studies have given less attention to the potential role of left ventricular reverse remodelling (LVRR), that is, the improvement of LV function and structure, in resolving LVT. In this study, we aim to
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Machine learning‐driven diagnostic signature provides new insights in clinical management of hypertrophic cardiomyopathy Esc Heart Fail. (IF 3.8) Pub Date : 2024-04-17 Shutong Liu, Peiyu Yuan, Youyang Zheng, Chunguang Guo, Yuqing Ren, Siyuan Weng, Yuyuan Zhang, Long Liu, Zhe Xing, Libo Wang, Xinwei Han
AimsIn an era of evolving diagnostic possibilities, existing diagnostic systems are not fully sufficient to promptly recognize patients with early‐stage hypertrophic cardiomyopathy (HCM) without symptomatic and instrumental features. Considering the sudden death of HCM, developing a novel diagnostic model to clarify the patients with early‐stage HCM and the immunological characteristics can avoid misdiagnosis
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Ca2+/calmodulin‐dependent kinase IIδC‐induced chronic heart failure does not depend on sarcoplasmic reticulum Ca2+ leak Esc Heart Fail. (IF 3.8) Pub Date : 2024-04-15 Matthias Dewenter, Tilmann Seitz, Julia H. Steinbrecher, B. Daan Westenbrink, Haiyun Ling, Stephan E. Lehnart, Xander H.T. Wehrens, Johannes Backs, Joan Heller Brown, Lars S. Maier, Stefan Neef
AimsHyperactivity of Ca2+/calmodulin‐dependent protein kinase II (CaMKII) has emerged as a central cause of pathologic remodelling in heart failure. It has been suggested that CaMKII‐induced hyperphosphorylation of the ryanodine receptor 2 (RyR2) and consequently increased diastolic Ca2+ leak from the sarcoplasmic reticulum (SR) is a crucial mechanism by which increased CaMKII activity leads to contractile
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Genetic predisposition in chemotherapy‐induced cardiomyopathy in a 65‐year‐old female with metastatic breast cancer Esc Heart Fail. (IF 3.8) Pub Date : 2024-04-15 So‐Young Lee, Hoon Seok Kim, Mi‐Hyang Jung, Suyon Chang, Myungshin Kim, Jong‐Chan Youn, Woo‐Baek Chung, Hae Ok Jung
The prevention and management of cancer therapy‐related cardiac dysfunction (CTRCD) have become increasingly important. Recent studies have revealed the crucial role of genetics in determining the susceptibility to development of CTRCD. We present a case of a 65‐year‐old woman with breast cancer who developed recurrent CTRCD following low‐dose chemotherapy, despite lacking conventional cardiovascular
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Long-term prognostic value of the H2FPEF score in patients undergoing transcatheter aortic valve implantation Esc Heart Fail. (IF 3.8) Pub Date : 2024-04-12 Kenichi Ishizu, Shinichi Shirai, Akihiro Isotani, Masaomi Hayashi, Hiroyuki Tabata, Nobuhisa Ohno, Shinichi Kakumoto, Kenji Ando, Fumiaki Yashima, Norio Tada, Masahiro Yamawaki, Toru Naganuma, Futoshi Yamanaka, Hiroshi Ueno, Minoru Tabata, Kazuki Mizutani, Kensuke Takagi, Yusuke Watanabe, Masanori Yamamoto, Kentaro Hayashida
A considerable proportion of candidates for transcatheter aortic valve implantation (TAVI) have underlying heart failure (HF) with preserved ejection fraction (HFpEF), which can be challenging for diagnosis because significant valvular heart disease should be excluded before diagnosing HFpEF. This study investigated the long-term prognostic value of the pre-procedural H2FPEF score in patients with
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Transition from asymptomatic to symptomatic systolic chronic heart failure: rationale and design of TransitionCHF Esc Heart Fail. (IF 3.8) Pub Date : 2024-04-12 Anja Sandek, Frank Edelmann, Christoph Gertler, Tim Friede, Rolf Wachter, Gerd Hasenfuß
Chronic systolic heart failure (CHF) is a major health burden. A relevant number of patients shows asymptomatic left ventricular dysfunction (ALVSD) before symptomatic CHF or becomes asymptomatic after initiating heart failure therapy. Clinical course, prognosis, and response to pharmacological and device-based treatment are largely unknown in these two distinct groups of patients. Current pharmacological
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Transthyretin amyloid cardiomyopathy among patients with heart failure and preserved ejection fraction: the AMY score Esc Heart Fail. (IF 3.8) Pub Date : 2024-04-13 Guglielmo Gioia, Lore Schrutka, Joanna Jozwiak‐Nozdrzykowska, Karl‐Patrik Kresoja, Hilka Gunold, Karin Klingel, Holger Thiele, Diana Bonderman, Philipp Lurz, Karl‐Philipp Rommel
AimsTransthyretin ‘wild‐type’ amyloid cardiomyopathy (ATTRwt‐CM) is a differential diagnosis of heart failure with preserved ejection fraction (HFpEF). The clinical work‐up for ATTRwt‐CM is challenging. Considering a combination of clinical variables specific for ATTRwt‐CM might aid in identifying patients at risk.Methods and resultsSixty patients (78 ± 6 years, 8% female) were diagnosed with ATTRwt‐CM
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Association of lactate/albumin ratio with 3‐month readmission risk in heart failure patients: a retrospective study Esc Heart Fail. (IF 3.8) Pub Date : 2024-04-13 Hui Sun, Baiqiang Wang, Guipeng An, Yun Zhang, Lianyue Ma
AimsThe predictive value of the lactate/albumin ratio (LAR) in mortality is established in various conditions, yet its relevance to 3‐month readmission risk in Chinese adults with heart failure (HF) remains unclear.Method and resultsAnalysing data from 957 patients with HF at Zigong Fourth People's Hospital, Sichuan, China (December 2016 to June 2019), we assessed baseline characteristics, vital signs
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Comment on: “A novel ‘shunt fraction’ method to derive native cardiac output during liberation from central VA ECMO” by Lim, HS Esc Heart Fail. (IF 3.8) Pub Date : 2024-04-12 Kaspar F. Bachmann, Matthias Haenggi, Stephan M. Jakob, Jukka Takala, Luciano Gattinoni, David Berger
We have read with interest the case report by Lim and his recent review of the Fick principle on veno-arterial extracorporeal membrane oxygenation (VA ECMO).1, 2 We are delighted that the measurement of native cardiac output during extracorporeal support found its successful way to the bedside. Still, we wonder how our work on the subject has gone unnoticed.3-6 We therefore take the liberty to offer
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ECMO for drug‐refractory electrical storm without a reversible trigger: a retrospective multicentric observational study Esc Heart Fail. (IF 3.8) Pub Date : 2024-04-12 Isabel Durães‐Campos, Catarina Costa, Ana Rita Ferreira, Carla Basílio, Pau Torrella, Aida Neves, Ana Margarida Lebreiro, Gonçalo Pestana, Luís Adão, José Pinheiro‐Torres, Miguel Solla‐Buceta, Jordi Riera, Juan Ignacio Chico‐Carballas, Sérgio Gaião, José Artur Paiva, Roberto Roncon‐Albuquerque
AimsDrug‐refractory electrical storm (ES) is a life‐threatening medical emergency. We describe the use of venoarterial extracorporeal membrane oxygenation (VA‐ECMO) in drug‐refractory ES without a reversible trigger, for which specific guideline recommendations are still lacking.Methods and resultsRetrospective observational study in four Iberian centres on the indications, treatment, complications
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Outcomes with T‐wave discordance of left bundle branch block and preserved or mildly reduced ejection fraction Esc Heart Fail. (IF 3.8) Pub Date : 2024-04-12 Hui‐Chun Huang, Kuo‐Liong Chien, Yen‐Bin Liu
AimsLeft bundle branch block (LBBB) is associated with an increased risk of adverse outcomes for patients with heart failure. The prognosis of LBBB in patients with a preserved ejection fraction (EF) remains controversial. This study investigated the predictive value of T‐wave discordance for the prognosis of patients with LBBB and preserved or mildly reduced EF.Methods and resultsWe enrolled 707 patients
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Paradox of disproportionate atrial functional mitral regurgitation and survival after transcatheter edge‐to‐edge repair Esc Heart Fail. (IF 3.8) Pub Date : 2024-04-11 Philipp M. Doldi, Lukas Stolz, Mohammad Kassar, Daniel Kalbacher, Anna Sonia Petronio, Christian Butter, Ralph Stephan von Bardeleben, Christos Iliadis, Paul Grayburn, Jörg Hausleiter
AimsThis study aims to assess the applicability of the mitral regurgitation (MR) proportionality concept in patients with atrial functional mitral regurgitation (aFMR) treated with transcatheter edge‐to‐edge repair (M‐TEER). We hypothesized that patients with disproportionate MR (higher MR relative to left ventricular size) would exhibit different outcomes compared to those with proportionate MR, despite
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Hypocapnia is associated with increased in‐hospital mortality and 1 year mortality in acute heart failure patients Esc Heart Fail. (IF 3.8) Pub Date : 2024-04-11 Lei Zhang, Yiwu Sun, Xin Sui, Jian Zhang, Jingshun Zhao, Runfeng Zhou, Wenjia Xu, Chengke Yin, Zhaoyi He, Yufei Sun, Chang Liu, Ailing Song, Fei Han
AimsBoth hypercapnia and hypocapnia are common in patients with acute heart failure (AHF), but the association between partial pressure of arterial carbon dioxide (PaCO2) and AHF prognosis remains unclear. The objective of this study was to investigate the connection between PaCO2 within 24 h after admission to the intensive care unit (ICU) and mortality during hospitalization and at 1 year in AHF
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Estimated pulse wave velocity and risk of new‐onset heart failure Esc Heart Fail. (IF 3.8) Pub Date : 2024-04-10 Chunpeng Ji, Guodong Wang, Zhe Huang, Chenrui Zhu, Yan Liu
AimsAs a potential surrogate of carotid‐femoral pulse wave velocity, estimated pulse wave velocity (ePWV) has been confirmed to independently predict the cardiovascular events, but the association between ePWV and heart failure has not been well confirmed. Therefore, we performed this cohort study to evaluate the association between ePWV and risk of new‐onset heart failure.Methods and resultsA total
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The peptide neuromedin U (NMU) is elevated in NYHA II and III heart failure Esc Heart Fail. (IF 3.8) Pub Date : 2024-04-06 Vincent Healy, Therese Ruane O'Hora, Farouk Markos
AimsCurrently, there is no reliable biomarker to detect pre‐heart failure in humans. An early risk signal is an elevated left atrial pressure (LAP) and preliminary results from animal studies strongly suggest the neuropeptide neuromedin U (NMU) is released in response to this increase in LAP. However, it is unknown whether NMU is elevated in patients with heart failure. Therefore, the aim of this study
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Association between pulmonary artery pulsatility and mortality after implantation of left ventricular assist device Esc Heart Fail. (IF 3.8) Pub Date : 2024-04-06 Ali Akamkam, Vincent Galand, Marie Jungling, Clément Delmas, Camille Dambrin, Mathieu Pernot, Michel Kindo, Philippe Gaudard, Philippe Rouviere, Thomas Senage, Olivier Chavanon, Marylou Para, Vlad Gariboldi, Matteo Pozzi, Pierre‐Yves Litzler, Gerard Babatasi, Olivier Bouchot, Costin Radu, Thierry Bourguignon, Nicolas D'Ostrevy, Ramzi Abi Akar, Fabrice Vanhuyse, Maïra Gaillard, Gilles Chatelier, Audrey
AimsRight ventricular failure after left ventricular assist device (LVAD) implantation is a major concern that remains challenging to predict. We sought to investigate the relationship between preoperative pulmonary artery pulsatility index (PAPi) and mortality after LVAD implantation.Methods and resultsA retrospective analysis of the ASSIST‐ICD multicentre registry allowed the assessment of PAPi before
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Achieved dose and treatment discontinuation of candesartan in men and women with chronic heart failure: data from CHARM Esc Heart Fail. (IF 3.8) Pub Date : 2024-04-06 Hailun Qin, Pooja Dewan, Bernadet T. Santema, Jozine M. ter Maaten, Karl Swedberg, John J. V. McMurray, Adriaan A. Voors
AimsAngiotensin receptor blockers have been shown to reduce heart failure hospitalization and cardiovascular mortality in men and women with heart failure with reduced ejection fraction (HFrEF). It is unknown whether there are differences between men and women in achieved dose and treatment discontinuation due to adverse events of candesartan.Methods and resultsWe conducted a post hoc analysis of the
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Non‐invasively assessed haemodynamics in patients with high flow arteriovenous fistula and high output cardiac failure Esc Heart Fail. (IF 3.8) Pub Date : 2024-04-05 Kristína Burýšková Salajová, Jan Malík, Anna Valeriánová
We have read with interest the recent paper in this journal by Lee et al.1 The authors examined 109 haemodialysis patients by detailed echocardiography and measured haemodialysis arteriovenous fistula (AVF) flow in a retrospective study. Then they followed them for a mean of 25 months, and during this time, 19 (17.4%) patients were hospitalized for high-output cardiac failure (HOCF). Lower estimated
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Care‐seeking delay of patients with heart failure in China: a mixed‐method study Esc Heart Fail. (IF 3.8) Pub Date : 2024-04-03 Mengqi Xu, Tiantian Ruan, Xiaoli Huang, Beibei Han, Yingqi Li, Yuan Ding, Lingyan Zhu
AimThis study aims to explore the duration and influencing factors of care‐seeking delay among patients with heart failure (HF) in China.Methods and resultsA convergent mixed method containing a cross‐sectional study and two parts of qualitative studies was designed, following the STROBE and COREQ guidelines. Convenience sampling was applied to recruit patients with HF from two general hospitals from
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Prognostic impact of frailty based on a comprehensive frailty assessment in patients with heart failure Esc Heart Fail. (IF 3.8) Pub Date : 2024-03-28 Tomoyuki Hamada, Toru Kubo, Kazuya Kawai, Yoko Nakaoka, Toshikazu Yabe, Takashi Furuno, Eisuke Yamada, Hiroaki Kitaoka
This study aimed to evaluate the impact of frailty and living function domains based on the Kihon Checklist (KCL), a questionnaire for a comprehensive frailty assessment, on prognosis in patients with acute heart failure (AHF).
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Increased interleukin‐6 is associated with higher risk of heart failure in people with type 2 diabetes Esc Heart Fail. (IF 3.8) Pub Date : 2024-03-29 Sharon Remmelzwaal, Stanley M.H. Yeung, Marieke T. Blom, Martin H. de Borst, Petra J.M. Elders, Joline W.J. Beulens
AimsWe aimed to determine the association between serum interleukin‐6 (IL‐6) concentrations and new‐onset heart failure (HF) in persons with type 2 diabetes (T2D).Methods and resultsWe performed a case–control study nested in the Diabetes Care System Cohort, a prospective cohort of persons with T2D in primary care. We included 724 participants, of whom 141 developed HF during 5 years of follow‐up and
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Intravenous iron and SGLT2 inhibitors in iron‐deficient patients with heart failure and reduced ejection fraction Esc Heart Fail. (IF 3.8) Pub Date : 2024-03-29 Kieran F. Docherty, John J.V. McMurray, Paul R. Kalra, John G.F. Cleland, Ninian N. Lang, Mark C. Petrie, Michele Robertson, Ian Ford
AimsTo explore the potential interaction between use of SGLT2 inhibitors and the increase in haemoglobin in patients randomized to intravenous iron or the control group in the IRONMAN (Effectiveness of Intravenous Iron Treatment versus Standard Care in Patients with Heart Failure and Iron Deficiency) trial.Methods and resultsThis was a post hoc exploratory analysis of the IRONMAN trial which randomized
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Twelve‐year trends in unprotected left main coronary artery occlusion: insights from a real‐world multicentre study Esc Heart Fail. (IF 3.8) Pub Date : 2024-03-29 André Alexandre, Andreia Campinas, Bruno Brochado, Marta Braga, David Sá‐Couto, Mariana Santos, Diana Ribeiro, Mariana Brandão, Marisa Passos Silva, Gustavo Pires de Morais, João Calvão, João Carlos Silva, Raquel Baggen‐Santos, André Luz, João Silveira, Severo Torres
AimsAcute myocardial infarction (AMI) resulting from unprotected left main coronary artery (LMCA) occlusion and subtotal occlusion is a life‐threatening condition. Although AMI management has improved in the past two decades, there is limited information on recent trends in patient characteristics, management, and outcomes for acute unprotected LMCA‐related AMI. This study aims to assess such trends
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Impact of coronary microvascular dysfunction in heart failure with preserved ejection fraction: a meta‐analysis Esc Heart Fail. (IF 3.8) Pub Date : 2024-03-29 Domenico D'Amario, Renzo Laborante, Emiliano Bianchini, Giuseppe Ciliberti, Donato Antonio Paglianiti, Mattia Galli, Attilio Restivo, Davide Stolfo, Rocco Vergallo, Giuseppe M.C. Rosano, Filippo Crea, Carolyn S.P. Lam, Lars H. Lund, Marco Metra, Giuseppe Patti, Gianluigi Savarese
AimsSeveral mechanisms have been identified in the aetiopathogenesis of heart failure with preserved ejection fraction (HFpEF). Among these, coronary microvascular dysfunction (CMD) may play a key pathophysiological role. We performed a systematic review and meta‐analysis to investigate the prevalence, echocardiographic correlates, and prognostic implications of CMD in patients with HFpEF.Methods and
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Issue Information Esc Heart Fail. (IF 3.8) Pub Date : 2024-03-27
No abstract is available for this article.
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Usefulness of oxygen uptake efficiency slope in a 6 min walk test in chronic heart failure Esc Heart Fail. (IF 3.8) Pub Date : 2024-03-26 Min Sun Kim, Woori Bong, Jung Hyun Choi, Myung‐Jun Shin, Byeong‐Ju Lee
AimsFrailty is an obstacle to performing cardiopulmonary exercise test (CPET) in patients with chronic heart failure (CHF). We evaluated the usefulness of oxygen uptake efficiency slope (OUES) using a 6 min walk test (6MWT) with portable gas analysis compared with CPET‐derived parameters in patients with CHF.Methods and resultsPatients with CHF who underwent both the 6MWT with portable gas analysis
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Fractional excretion of urea nitrogen can identify true worsening renal function in patients with heart failure Esc Heart Fail. (IF 3.8) Pub Date : 2024-03-24 Yukihiro Watanabe, Yoshiaki Kubota, Takuya Nishino, Shuhei Tara, Katsuhito Kato, Daisuke Hayashi, Junya Matsuda, Hideki Miyachi, Yukichi Tokita, Yu‐ki Iwasaki, Kuniya Asai
AimsFractional excretion of urea nitrogen (FEUN), used to differentiate the cause of acute kidney injury, has emerged as a useful fluid index in patients with heart failure (HF). We hypothesized that FEUN could be useful in identifying worsening renal function (WRF) associated with poor outcomes in patients with acute HF (AHF).Methods and resultsOverall, 1103 patients with AHF (median age, 78 years;
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CH‐VAD left ventricular assist implantation combined with the Bentall procedure and coronary artery bypass grafting Esc Heart Fail. (IF 3.8) Pub Date : 2024-03-23 Shuanglei Zhao, Chongyang Liu, Jun Wang, Hong Wang, Tiange Luo, Xiaoyan Hao, Xian Yang, Mingxiu Wen, Jie Han, Hongjia Zhang, Ming Gong
Left ventricular assist device (LVAD) implantation is an effective alternative treatment to heart transplantation, especially for end‐stage heart failure patients who are ineligible for or unable to await a heart transplant. This report describes a complex and innovative surgery where LVAD implantation was performed alongside multiple concomitant cardiac and aortic procedures. A 62‐year‐old male patient
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Echocardiographic haemodynamic monitoring in the context of HeartMate 3™ therapy: a systematic review Esc Heart Fail. (IF 3.8) Pub Date : 2024-03-23 Linus Ohlsson, Joanna‐Maria Papageorgiou, Tino Ebbers, Meriam Åström Aneq, Éva Tamás, Hans Granfeldt
AimsWhile echocardiography remains essential within haemodynamic monitoring of durable mechanical circulatory support, previous echocardiographic guidelines are missing scientific evidence for the novel HeartMate 3™ (HM3) system. Accordingly, this review aims to summarize available echocardiographic evidence including HM3.Methods and resultsThis systematic review adhered to the PRISMA 2020 guidelines
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Heart failure care in the Central and Eastern Europe and Baltic region: status, barriers, and routes to improvement Esc Heart Fail. (IF 3.8) Pub Date : 2024-03-23 Ovidiu Chioncel, Jelena Čelutkienė, Jan Bělohlávek, Ginta Kamzola, Mitja Lainscak, Béla Merkely, Davor Miličić, Jadwiga Nessler, Arsen D. Ristić, Lidia Sawiełajc, Izabella Uchmanowicz, Tiina Uuetoa, Eva Turgonyi, Yoto Yotov, Piotr Ponikowski
Despite improvements over recent years, morbidity and mortality associated with heart failure (HF) are higher in countries in the Central and Eastern Europe and Baltic region than in Western Europe. With the goal of improving the standard of HF care and patient outcomes in the Central and Eastern Europe and Baltic region, this review aimed to identify the main barriers to optimal HF care and potential
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Long‐term cost‐effectiveness of transcatheter mitral valve repair in HF patients with secondary mitral regurgitation Esc Heart Fail. (IF 3.8) Pub Date : 2024-03-22 Younan Yao, Ziyou Zhou, Tian Geng, Anping Cai, Tian Li, Junqing Yang, Jiyan Chen, Liwen Li
AimsThe long‐term cost‐effectiveness of MitraClip in heart failure patients with secondary mitral regurgitation is still unclear. This study aimed to evaluate the long‐term cost‐effectiveness of MitraClip added to guideline‐directed medical therapy vs. guideline‐directed medical therapy alone in heart failure patients with secondary mitral regurgitation from the perspective of the healthcare systems
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Impact of heart rate changes during hospitalization on outcome in heart failure with preserved ejection fraction Esc Heart Fail. (IF 3.8) Pub Date : 2024-03-22 Dan Liu, Xiaotong Cui, Yamei Xu, Lei Xu, Zhonglei Xie, Shuai Yuan, Peng Wang, Yanyan Wang, Sanli Qian, Hui Gong, Peter Nordbeck, Jiefu Yang, Jingmin Zhou, Junbo Ge, Aijun Sun
AimsThe benefits of lowering heart rate (HR) in heart failure (HF) with preserved ejection fraction (HFpEF) patients are still a matter of debate. This study aimed to investigate the relationship between changes in HR during hospitalization and cardiovascular (CV) events and all‐cause death in hospitalized HFpEF patients.Methods and resultsHospitalized HF patients between January 2017 and December
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Cardiovascular disease healthcare trajectories: descriptions, similarities, mortality rates of heart failure in France Esc Heart Fail. (IF 3.8) Pub Date : 2024-03-21 Camille Nevoret, Yohann Tran, Soulef Guendouz, Audrey Lavenu, Sandrine Katsahian, Thibaud Damy, Anne‐Isabelle Tropeano
AimsThe primary objectives of this study were to analyse the nationwide healthcare trajectories of heart failure (HF) patients in France, 2 years after their first hospitalization, and to measure sequence similarities. Secondary objectives were to identify the association between trajectories and the risk of mortality.Methods and resultsA retrospective, observational study was conducted using data
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Analysis of the serum levels of RIP3 and Drp1 in patients with heart failure Esc Heart Fail. (IF 3.8) Pub Date : 2024-03-21 Izabela Jarabicová, Csaba Horváth, Martin Chudý, Eva Goncalvesová, Adriana Adameová
AimsAs necroptosis involving receptor‐interacting protein kinase 3 (RIP3) and dynamin‐related protein 1 (Drp1)‐mediated signalling is a crucial mechanism of cell loss in heart failure (HF), we aimed to determine the potential diagnostic use of these molecules.Methods and resultsThe serum samples of the healthy subjects (n = 8) and patients with HF with reduced ejection fraction (n = 31), being subdivided
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Assessing the diversity and determinants of health‐related quality of life measures in patients with acute heart failure Esc Heart Fail. (IF 3.8) Pub Date : 2024-03-21 Dhrumil Patil, Hsin‐Ju Tang, Fang‐Hsiu Kuo, Han Siong Toh, I‐Ning Yang, Wei‐Ting Chang, Mei‐Chuan Lee, Kai‐Ning Chung, Chi‐Ya Huang, Wan‐Hsuan Hsu, Ting‐Chia Chang, Jhih‐Yuan Shih, Chia‐Te Liao
AimsHeart failure with reduced ejection fraction (HFrEF) significantly impacts health‐related quality of life (HR‐QoL). Existing HR‐QoL questionnaires can show inconsistencies, potentially misrepresenting patient self‐reports. This study examines the variation in HR‐QoL measurement tools for HFrEF patients, identifying related determinants.Methods and resultsWe retrospectively analysed 134 hospitalized
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Novel SCN5A gene mutation in a patient affected by multifocal ectopic premature Purkinje‐related contractions syndrome Esc Heart Fail. (IF 3.8) Pub Date : 2024-03-20 Nicoletta Ventrella, Lorenzo Bianchini, Stefania Riva, Francesca Pizzamiglio, Maria Antonietta Dessanai, Fabrizio Tundo, Tommaso Sattin, Francesca De Lio, Selene Cellucci, Claudio Tondo
We report the case of a 36‐year‐old woman who presented to the emergency department complaining of palpitations and asthenia. Investigations showed frequent ventricular ectopy and severe left ventricular ejection fraction impairment. She was diagnosed with a peculiar condition defined multifocal ectopic premature Purkinje‐related contractions syndrome, which in some cases can be associated with a dilated
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Assessing the impact of haemodynamic monitoring with CardioMEMS on heart failure patients: a cost–benefit analysis Esc Heart Fail. (IF 3.8) Pub Date : 2024-03-19 Pau Codina, José Ángel Vicente Gómez, Guillem Hernández Guillamet, Laura Ricou Ríos, Andrea Carrete, Victoria Vilalta, Oriol Estrada, Jordi Ara, Josep Lupón, Antoni Bayés‐Genís, Francesc López Seguí
AimsThe objective of this study was to perform a cost–benefit analysis of the CardioMEMS HF System (Abbott Laboratories, Abbott Park, IL, USA) in a heart failure (HF) clinic in Spain by evaluating the real‐time remote monitoring of pulmonary artery pressures, which has been shown to reduce HF‐related hospitalizations and improve the quality of life for selected HF patients. Particularly, the study
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Pupil reflex as a marker of activity and prognosis in heart failure: a longitudinal and prospective study Esc Heart Fail. (IF 3.8) Pub Date : 2024-03-18 Margarita Zamorano, Juan Manuel Monteagudo, Eduardo González, Isabel Rayo, Sara Fernández, Miguel Castillo, Qiheng Zhou, Pedro de la Villa, Jose Luis Zamorano
AimsCompensatory mechanisms in heart failure (HF) are triggered to maintain adequate cardiac output. Among them, hyperactivation of the sympathetic nervous system (SNS) is one of the main ones and carries a worse prognosis. The pupillary reflex depends on the SNS, and we can evaluate it through pupillometry. The aim of the study was to compare the differences in pupillary reflex between patients with
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Obesity: the perfect storm for heart failure Esc Heart Fail. (IF 3.8) Pub Date : 2024-03-16 Maria Lembo, Teresa Strisciuglio, Celeste Fonderico, Costantino Mancusi, Raffaele Izzo, Valentina Trimarco, Alessandro Bellis, Emanuele Barbato, Giovanni Esposito, Carmine Morisco, Speranza Rubattu
Obesity condition causes morphological and functional alterations involving the cardiovascular system. These can represent the substrates for different cardiovascular diseases, such as atrial fibrillation, coronary artery disease, sudden cardiac death, and heart failure (HF) with both preserved ejection fraction (EF) and reduced EF. Different pathogenetic mechanisms may help to explain the association
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Socio‐economic position, multimorbidity, and health care utilization among Danish left ventricular assist device patients Esc Heart Fail. (IF 3.8) Pub Date : 2024-03-16 Inge Schjødt, Rikke E. Mols, István Bakos, Erzsébet Horváth‐Puhó, Finn Gustafsson, Søren L. Kristensen, Johan E. Larsson, Bo Christensen, Hans Eiskjær, Brian B. Løgstrup
AimsIncreasing numbers of patients with advanced heart failure and significant comorbidity and social barriers are considered for left ventricular assist devices (LVADs). We sought to examine health care utilization post‐LVAD implantation, including the influence of individual‐level socio‐economic position and multimorbidity.Methods and resultsWe conducted a Danish nationwide cohort study linking individual‐level
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Optimal combination of right ventricular functional parameters using echocardiography in pulmonary arterial hypertension Esc Heart Fail. (IF 3.8) Pub Date : 2024-03-16 Qimou Li, Yu Zhang, Xiaopei Cui, Weida Lu, Qiushang Ji, Mei Zhang
AimsNovel echocardiographic parameters of right ventricular (RV) function, including speckle‐tracking‐derived, three‐dimensional, and RV–pulmonary artery coupling parameters, have emerged for the evaluation of pulmonary arterial hypertension (PAH). The relative role of these parameters in the risk stratification of PAH patients is unclear. We compared the performance of multiple RV parameters and sought
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Correction to “Impedance-based remote monitoring in patients with heart failure and concomitant chronic kidney disease” Esc Heart Fail. (IF 3.8) Pub Date : 2024-03-15
Wintrich, J, Pavlicek, V, Brachmann, J, Bosch, R, Butter, C, Oswald, H, Rybak, K, Mahfoud, F, Böhm, M, Ukena, C. Impedance-based remote monitoring in patients with heart failure and concomitant chronic kidney disease. ESC Heart Fail 2023; 10: 3011–3018.10.1002/ehf2.14387 The below funding statement for this article was missing: Open Access funding enabled and organized by Projekt DEAL.
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Impact of epicardial adipose tissue on cardiac function and morphology in patients with diastolic dysfunction Esc Heart Fail. (IF 3.8) Pub Date : 2024-03-14 Alexander Schulz, Sören J. Backhaus, Torben Lange, Ruben Evertz, Shelby Kutty, Johannes T. Kowallick, Gerd Hasenfuß, Andreas Schuster
AimsThis study aimed to identify the impact of increased epicardial adipose tissue (EAT) and its regional distribution on cardiac function in patients with diastolic dysfunction.Methods and resultsSixty‐eight patients with exertional dyspnoea (New York Heart Association ≥II), preserved ejection fraction (≥50%), and diastolic dysfunction (E/e′ ≥ 8) underwent rest and stress right heart catheterization
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Systemic sclerosis is associated with increased in‐patient mortality in patients hospitalized for heart failure Esc Heart Fail. (IF 3.8) Pub Date : 2024-03-13 Akil A. Sherif, Vinit J. Gilvaz, Sonu Abraham, Anu Mariam Saji, Don Mathew, Ameesh Isath, Aiswarya Rajendran, Johanna Contreras, Gregg M. Lanier, Anthony M. Reginato
AimsWe aimed to analyse the characteristics and in‐hospital outcomes of patients hospitalized for heart failure (HF) with co‐morbid systemic sclerosis (SSc) and compare them to those without SSc, using data from the National Inpatient Sample from years 2016 to 2019.Methods and resultsInternational Classification of Diseases, Tenth Revision diagnosis codes were used to identify hospitalized patients