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PPARβ/δ as a promising molecular drug target for liver diseases: A focused review Clin. Res. Hepatol. Gastroenterolog. (IF 2.7) Pub Date : 2024-04-18 Xin Meng, Lin Wang, Yan-Chao Du, Dong Cheng, Tao Zeng
Various liver diseases pose great threats to humans. Although the etiologies of these liver diseases are quite diverse, they share similar pathologic phenotypes and molecular mechanisms such as oxidative stress, lipid and glucose metabolism disturbance, hepatic Kupffer cell (KC) proinflammatory polarization and inflammation, insulin resistance, and hepatic stellate cell (HSC) activation and proliferation
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The role of cognitive emotion regulation strategies in predicting the resilience, symptom severity, and quality of life of patients with irritable bowel syndrome Clin. Res. Hepatol. Gastroenterolog. (IF 2.7) Pub Date : 2024-04-10 Amir M. Sadeghian, Farzad Dashti, Behnam Shariati, Marjan Mokhtare, Mohammadjavad Sotoudeheian
Psychosocial stressors contribute to the development of irritable bowel syndrome (IBS) and exacerbate the symptoms. The capability to cope with stress is an essential element in the management of IBS. This study assessed nine cognitive emotion regulation strategies (CERS) and their role in predicting symptom severity, quality of life (QOL), and resilience in IBS subjects. The scores regarding nine
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Outcomes and factors associated with cryptococcal disease among cirrhotics: A study of the national inpatient sample 2005 to 2014 Clin. Res. Hepatol. Gastroenterolog. (IF 2.7) Pub Date : 2024-04-10 Kishan Patel, Patrick Twohig, Thoetchai Peeraphatdit, Erica J Stohs, Kaeli Samson, Lynette Smith, Jay Patel, Wuttiporn Manatsathit
Cryptococcal disease (CD) confers a higher mortality in cirrhotic patients compared to non-cirrhotic patients. Factor association for CD in cirrhotic patients is poorly understood. Our aim was to determine the incidence, demographic, and comorbidities associated with CD among cirrhotic patients in the United States (US). Retrospective analysis of admissions of cirrhotic patients, with or without CD
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White adipose tissue in metabolic associated fatty liver disease Clin. Res. Hepatol. Gastroenterolog. (IF 2.7) Pub Date : 2024-04-10 Xiaoqin Zhu, Chuanfei Zeng, Baoping Yu
Metabolic associated fatty liver disease (MAFLD) is a prevalent chronic liver condition globally, currently lacking universally recognized therapeutic drugs, thereby increasing the risk of cirrhosis and hepatocellular carcinoma. Research has reported an association between white adipose tissue and MAFLD. White adipose tissue (WAT) is involved in lipid metabolism and can contribute to the progression
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Therapeutic benefit of probiotic in alcohol dependence syndrome: Evidence from a tertiary care centre of India Clin. Res. Hepatol. Gastroenterolog. (IF 2.7) Pub Date : 2024-04-09 Dinesh Panati, Jayapriya Timmapuram, Swetha Puthalapattu, Tatikonda Padma Sudhakar, Sirshendu Chaudhuri
Probiotic adjuvant has promising effects in treating alcohol induced hepatitis, depression, and anxiety. This study aimed to assess the effectiveness of adjuvant probiotic use in improving the liver functions, anxiety, and depression among patients with alcohol dependence syndrome (ADS) in a tertiary care hospital in Andhra Pradesh, India. In this prospective observational design, ADS patients with
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A rare case of gastroduodenal glomus tumor Clin. Res. Hepatol. Gastroenterolog. (IF 2.7) Pub Date : 2024-04-08 Na Wu, Yi Ding, Wei-Feng Huang
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Phenotype and molecular characterization of Wilson's disease in Morocco Clin. Res. Hepatol. Gastroenterolog. (IF 2.7) Pub Date : 2024-04-06 Nadia Abbassi, Aicha Bourrahouat, Eduardo Couchonnal Bedoya, Cécile Pagan, Meriem El Qabli, Sana Maidoumi, Abdelouahed Belmalih, Olivier Guillaud, Najib Kissani, Abdelhak Abkari, Imane Chahid, Mohammed Abdoh Rafai, Nezha Mouane, Yamna Kriouile, Saadia Aidi, Moustpha Hida, Mounia Lakhdar Idrissi, Mohammed Faouzi Belahsen, Mohammed El Abkari, Maria Rkain, Zahi Ismaili, Azeddine Sedki, Muriel Bost, Nisrine
In Morocco the prevalence of Wilson disease (WD) and the spectrum of mutations are not known. The aim of the present study was to estimate the prevalence of WD in Morocco, to evaluate the phenotype among a large cohort of WD patients, and to characterize variants in a subgroup of WD patients. We collected data from 226 patients admitted to five university hospital centers in Morocco between 2008 and
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Neonatal jaundice caused by compound mutations of SLC10A1 and a novel UGT1A1 gene Clin. Res. Hepatol. Gastroenterolog. (IF 2.7) Pub Date : 2024-04-06 Meifen Wang, Tao Chen, Rui Chen, Zhongrui Bi, Junchao Peng, Qi Shao, Jiwei Li
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Endoscopic submucosal dissection for early esophageal squamous cell carcinoma after ligation and sclerotherapy of esophageal and gastric varices Clin. Res. Hepatol. Gastroenterolog. (IF 2.7) Pub Date : 2024-04-06 Sio-Hou Wong, Hoi-Ioi Ng, Yong Liu, Hon-Ho Yu, Gui-Qi Wang
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Automated detection of small bowel lesions based on capsule endoscopy using deep learning algorithm Clin. Res. Hepatol. Gastroenterolog. (IF 2.7) Pub Date : 2024-04-04 Lan Li, Liping Yang, Bingling Zhang, Guofei Yan, Yaqing Bao, Renke Zhu, Shengjie Li, Huogen Wang, Ming Chen, Chaohui Jin, Yishu Chen, Chaohui Yu
In order to overcome the challenges of lesion detection in capsule endoscopy (CE), we improved the YOLOv5-based deep learning algorithm and established the CE-YOLOv5 algorithm to identify small bowel lesions captured by CE. A total of 124,678 typical abnormal images from 1,452 patients were enrolled to train the CE-YOLOv5 model. Then 298 patients with suspected small bowel lesions detected by CE were
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Sarcopenia does not affect liver regeneration and postoperative course after a major hepatectomy. A prospective study on 125 patients using CT volumetry and HIDA scintigraphy Clin. Res. Hepatol. Gastroenterolog. (IF 2.7) Pub Date : 2024-04-02 Maxence Fulbert, Mehdi El Amrani, Clio Baillet, Katia Lecolle, Olivier Ernst, Alexandre Louvet, François-René Pruvot, Damien Huglo, Stéphanie Truant
Sarcopenia is a morbi-mortality risk factor in digestive surgery, though its impact after major hepatectomy (MH) remains unknown. This prospective pilot study investigated whether volume and function of a regenerating liver is influenced by body composition. From 2011 to 2016, 125 consecutive patients had computed tomography and 99mTc-labelled-mebrofenin SPECT-scintigraphy before and after MH at day
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Massive lymphatic embolism in gallbladder signet ring cell carcinoma: An autopsy finding. Clin. Res. Hepatol. Gastroenterolog. (IF 2.7) Pub Date : 2024-03-27 Giulia Martinelli, Stefano Stanca, Francesca Bosco, Leonardo Zini, Francesco De Masi, Greta Alì
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The smoker's paradox in transjugular intrahepatic portosystemic shunt procedure: A national inpatient sample analysis from 2015 to 2020 Clin. Res. Hepatol. Gastroenterolog. (IF 2.7) Pub Date : 2024-03-26 Renxi Li, Shawn Sarin
Transjugular intrahepatic portosystemic shunt (TIPS) is a procedure used to alleviate patients with chronic liver cirrhosis and portal hypertension. Smoking can adversely impact liver function and has been shown to influence liver-related outcomes. This study aimed to examine the impact of smoking on the immediate outcomes of TIPS procedure. The study compared smokers and non-smokers who underwent
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Endoscopic features of low-phospholipid-associated cholelithiasis syndrome: A retrospective cohort study Clin. Res. Hepatol. Gastroenterolog. (IF 2.7) Pub Date : 2024-03-23 G. Salin, C. Corpechot, S. Ouazana, C. Dong, A. Becq, S. Lemoinne, K. Ben Belkacem, R. Leenhardt, U. Chaput, O. Chazouillères, J. Kirchgesner, M. Camus
LPAC (low phospholipid-associated cholelithiasis) syndrome is a rare genetic form of cholelithiasis. ERCP (endoscopic retrograde cholangiopancreatography) is often used to remove gallstones in the bile duct. No published data is available on the role of ERCP in LPAC syndrome. In this retrospective cohort study, we included patients diagnosed with LPAC syndrome in a single tertiary referral center between
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Extrahepatic conditions of primary biliary cholangitis: A systematic review and meta-analysis of prevalence and risk Clin. Res. Hepatol. Gastroenterolog. (IF 2.7) Pub Date : 2024-03-20 Yan Liang, Jie Li, Zhiyu Zhang, Tingwang Jiang, Zaixing Yang
Many studies reported the prevalence of extrahepatic conditions (EHC) of primary biliary cholangitis (PBC), but the great heterogeneity existed across different studies. Therefore, we conducted the systematic review and meta-analyses to determine EHC prevalence and association with PBC. We searched PUBMED and included observational, cross-sectional and case-controlled studies. A random or fixed effects
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Pathophysiology and management of enteric hyperoxaluria Clin. Res. Hepatol. Gastroenterolog. (IF 2.7) Pub Date : 2024-03-19 Jordan Desenclos, Valentine Forté, Cécile Clément, Michel Daudon, Emmanuel Letavernier
Enteric hyperoxaluria is a metabolic disorder resulting from conditions associated with fatty acid malabsorption and characterized by an increased urinary output of oxalate. Oxalate is excessively absorbed in the gut and then excreted in urine where it forms calcium oxalate crystals, inducing kidney stones formation and crystalline nephropathies. Enteric hyperoxaluria is probably underdiagnosed and
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The diagnostic performance of serum αvβ6 autoantibodies for ulcerative colitis: A systematic review and meta-analysis Clin. Res. Hepatol. Gastroenterolog. (IF 2.7) Pub Date : 2024-03-16 Jiao Yang, M.M. Cai Huang, M.M. Jing-Wen Liang, M.M. Yan-Chang Lei
Currently, there is no single golden standard for diagnosing ulcerative colitis (UC). Now serum αvβ6 autoantibodies have shown promise as a diagnostic tool for UC. Here the aim was to determine the diagnostic performance of serum αvβ6 autoantibodies for UC. PubMed, the Cochrane Library, the Embase, and the Web of Science were searched comprehensively. STATA software was utilized to analyze the relevant
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Independent and joint association of physical activity and adequate weekday sleep duration with metabolic dysfunction-associated steatotic liver disease Clin. Res. Hepatol. Gastroenterolog. (IF 2.7) Pub Date : 2024-03-12 Yaxin Li, Yitian Guo, Shiyun Tan
The independent and joint association of physical activity (PA) and weekday sleep duration with metabolic dysfunction-associated steatotic liver disease (MASLD) remain unclear. Aims: We intended to explore this association in the United States. This cross-sectional study recruited 4974 individuals from the National Health and Nutrition Examination Survey between 2017 and 2018. Information regarding
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A novel homozygous mutation, c.662_672del, in DGUOK gene causing mitochondrial DNA depletion syndrome of type hepatocerebral – A case report Clin. Res. Hepatol. Gastroenterolog. (IF 2.7) Pub Date : 2024-03-11 Kandula Radhakrishna, Batchu Rajsekhar, K. V. Raja Ramesh, Neelima Chitturi, Sandhya Kiran Pemmasani, Anuradha Acharya
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Construction and validation of classification models for predicting the response to concurrent chemo-radiotherapy of patients with esophageal squamous cell carcinoma based on multi-omics data Clin. Res. Hepatol. Gastroenterolog. (IF 2.7) Pub Date : 2024-03-11 Zhi-Mao Li, Wei Liu, Xu-Li Chen, Wen-Zhi Wu, Xiu-E. Xu, Man-Yu Chu, Shuai-Xia Yu, En-Min Li, He-Cheng Huang, Li-Yan Xu
Concurrent chemo-radiotherapy (CCRT) is the preferred non-surgical treatment for patients with locally advanced esophageal squamous cell carcinoma (ESCC). Unfortunately, some patients respond poorly, which leads to inappropriate or excessive treatment and affects patient survival. To accurately predict the response of ESCC patients to CCRT, we developed classification models based on the clinical,
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Safety and efficacy of dexmedetomidine vs. midazolam in complex gastrointestinal endoscopy: A systematic review and meta-analysis Clin. Res. Hepatol. Gastroenterolog. (IF 2.7) Pub Date : 2024-03-10 Wei Liu, Xiaoyan Ge, Fang Gao, Qingfang Kan, Shaohua Wang, Yikai Wang, Chuan He
This study aims to perform a meta-analysis to evaluate the safety and efficacy of dexmedetomidine versus midazolam for complex digestive endoscopy procedures, with the goal of offering comprehensive clinical evidence. Following predefined inclusion criteria, five databases were systematically searched, with a focus on identifying randomized controlled trials (RCTs) that compared the administration
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Effectiveness of metformin for the reversal of cold-ischemia-induced damage in hepatosteatosis Clin. Res. Hepatol. Gastroenterolog. (IF 2.7) Pub Date : 2024-03-10 Mustafa Oruc, Mustafa Emre Gedik, Meral Uner, Elif Ulug, Reyhan Nergiz Unal, Gurcan Gunaydin, Ahmet Bulent Dogrul
Primary dysfunction and rejection are more common in donor liver tissues with steatosis. AMP-activated protein kinase (AMPK) assumes organ-protective functions during ischemia. Metformin was used for the activation of AMPK in hepatocytes. The aim of this study is to investigate the effectiveness of metformin administration for the reversal of cold-ischemia-induced damage in hepatosteatosis. Seven-week-old
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Acantholytic squamous cell carcinoma of the gallbladder: Report of a rare case with diagnostic challenges Clin. Res. Hepatol. Gastroenterolog. (IF 2.7) Pub Date : 2024-03-07 Xiaolei Yue, Shi Cao, Yonglin Chen
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Efficacy and safety of drug-eluting bead transarterial chemoembolization (DEB-TACE) combined with tyrosine kinase inhibitors (TKIs) in patients with unresectable hepatocellular carcinoma (uHCC): A systematic review and meta-analysis Clin. Res. Hepatol. Gastroenterolog. (IF 2.7) Pub Date : 2024-03-05 Jun Ji, Zhihong Zhang, Ziqi Hou, Guoteng Qiu, Shizheng Mi, Zhaoxing Jin, Jiwei Huang
The optimal management of unresectable hepatocellular carcinoma (uHCC) remains an unresolved challenge. There is ongoing debate regarding the efficacy and safety of drug-eluting bead TACE (DEB-TACE) with tyrosine kinase inhibitors (TKIs). We searched PubMed, Embase, Web of Science and the Cochrane Library for eligible studies. The main endpoints under investigation were survival outcomes, including
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The impact of secondhand smoke on failure of Helicobacter pylori therapy is not inferior to that of smoking Clin. Res. Hepatol. Gastroenterolog. (IF 2.7) Pub Date : 2024-02-29 Jiajia Wu, Zheng Qian, Dingfu Zhong, Min Lin
Previous studies have shown the associations between smoking and failure to eradicate Helicobacter pylori (H. pylori), but less is known about the impact of secondhand tobacco smoke (SHS) on H. pylori eradication. Between July 2022 to July 2023, 646 patients who received proton pump inhibitor (PPIs) as first-line H. pylori eradication therapy were recruited for the study. Information was obtained via
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Chronic gastrointestinal immune-related adverse events in patients exposed to immune checkpoint inhibitors Clin. Res. Hepatol. Gastroenterolog. (IF 2.7) Pub Date : 2024-02-29 Marine Jeay, Franck Carbonnel, Caroline Robert, Charlotte Mussini, Christophe Bellanger, Antoine Meyer
Immune checkpoint inhibitors (ICI) cause acute gastrointestinal (GI) immune-related adverse events (IrAEs). We aimed to report and describe chronic GI IrAEs. We included consecutive patients addressed to a single center between October 2010 and March 2022 for endoscopic and/or histological GI inflammation persisting at least six months after the last dose of ICI. Among a total of 178 patients addressed
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Gastric adenocarcinoma of fundic gland (chief cell predominant) type Clin. Res. Hepatol. Gastroenterolog. (IF 2.7) Pub Date : 2024-02-22 Dong-Ge Han, Ke Wang, Wei Liu
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Neuroendocrine tumor of the major duodenal papilla Clin. Res. Hepatol. Gastroenterolog. (IF 2.7) Pub Date : 2024-02-18 Wei Liu, Dong-Ge Han, Lin Cheng
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Sodium taurocholate cotransporter polypeptide deficiency from two pairs of twins with homozygous and heterozygous of p.Ser267Phe variant, respectively: Case report Clin. Res. Hepatol. Gastroenterolog. (IF 2.7) Pub Date : 2024-02-16 Meifen Wang, Tao Chen, Meirui Li, Rui Chen, Junchao Peng, Jiwei Li
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Efficacy and safety of precutting endoscopic mucosal resection versus endoscopic submucosal dissection for non-ampullary superficial duodenal lesions Clin. Res. Hepatol. Gastroenterolog. (IF 2.7) Pub Date : 2024-02-16 Dawei Chen, Sunya Fu, Jianwei Shen
Endoscopic treatments for non-ampullary superficial duodenal lesions (NASDLs) are yet to be standardized. Endoscopic submucosal dissection (ESD) for NASDLs demands advanced techniques and a long procedure time to prevent perforation and bleeding. Precutting endoscopic mucosal resection (EMR) is a technical modification of ESD that overcomes the limitations of ESD. This study aimed to compare the efficacy
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Bilateral optic atrophy in Wilson disease: A case report and literature review Clin. Res. Hepatol. Gastroenterolog. (IF 2.7) Pub Date : 2024-02-15 Fei Chen, Chunli Chen, Yang Zhang, Libin Jiang, Zhiqin Huang, Fred K Chen
Wilson disease (WD) is an autosomal recessive disorder of copper metabolism. The clinical manifestations of WD are complex and variable, with Kayser–Fleischer ring (K-F ring) and the sunflower cataract being the most common ocular findings. Visual impairment is rare in patients with WD. We report the case of a 17-year-old female with bilateral optic atrophy associated with WD and summarize the clinical
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Thermal ablation for hepatic tumors in high-risk locations Clin. Res. Hepatol. Gastroenterolog. (IF 2.7) Pub Date : 2024-02-15 Elijah Ndhlovu, Bi-Xiang Zhang, Xiao-Ping Chen, Peng Zhu
Thermal ablative techniques such as radiofrequency and microwave ablation are minimally invasive and cost-effective approaches that are currently being adopted as alternatives to surgical resection for primary and metastatic liver malignancies. However, they are considered to be relatively contraindicated for tumors in high-risk locations due to technical difficulties and a perceived increased risk
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Increased risk of colorectal adenomas with metabolic-associated fatty liver disease components Clin. Res. Hepatol. Gastroenterolog. (IF 2.7) Pub Date : 2024-02-15 Dongsheng Ran, ChunLing Xin, Yingcai Ma, Yanyan Lu
Metabolic (dysfunction)-associated fatty liver disease is the most common liver disease related to various metabolic disorders. Colorectal adenomas are related to metabolic dysregulation. Despite the proposed association between non-alcoholic fatty liver disease and colorectal adenomas, the influence of metabolic-associated fatty liver disease on colorectal adenomas has yet to be investigated. Our
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Computed tomography-guided percutaneous cryoablation and microwave ablation in the treatment of perivascular hepatocellular carcinoma: A comparative study with propensity score matching Clin. Res. Hepatol. Gastroenterolog. (IF 2.7) Pub Date : 2024-02-15 Bing Li, Zi Wang Ren, Chuan Zhang, Xiao Xuan Yu, Xiao Xue Xu, Yong Du, Han Feng Yang
To evaluate the safety and efficacy of cryoablation (CYA) and microwave ablation (MWA) in the treatment of patients with perivascular hepatocellular carcinoma (HCC). Patients with perivascular HCC who underwent computed tomography (CT)-guided percutaneous CYA or MVA treatment in our hospital from August 2009 to March 2019 were included. Propensity score matching (PSM) was performed to adjust for potential
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Social determinants of health influencing the adherence to post-endoscopic mucosal resection surveillance Clin. Res. Hepatol. Gastroenterolog. (IF 2.7) Pub Date : 2024-02-13 Bijal Vashi, Dalton A. Norwood, Rebecca Sullivan, Yassmin Hegazy, Sergio A. Sánchez-Luna, Patricia Ajayi-Fox, Ali M. Ahmed, Kondal R. Kyanam Kabir Baig, Shajan Peter, Ramzi Mulki
: Colorectal cancer (CRC) is a global health challenge, particularly in Alabama, where the incidence rates exceed national averages. This study investigated the factors influencing adherence to post-endoscopic mucosal resection (EMR) colonoscopies, focusing on travel distance and socioeconomic status. This study aimed to provide evidence-based insights to improve patient care in CRC management. This
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Progress in the treatment and prevention of esophageal stenosis after endoscopic submucosal dissection Clin. Res. Hepatol. Gastroenterolog. (IF 2.7) Pub Date : 2024-02-03 Yangyang Duan, Wenxiu Jia, Ying Liang, Xiuning Zhang, Zhufeng Yang, Qian Yang
The primary treatment for early esophageal cancer and precancerous lesions is endoscopic submucosal dissection (ESD). However, this approach leads to a high incidence of postoperative esophageal stenosis, which can significantly impact a patient's quality of life. While various methods are available to prevent post-ESD esophageal stenosis, their effectiveness varies. Therefore, this study aims to provide
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Clinical significance of ribosome production factor 2 homolog in hepatocellular carcinoma Clin. Res. Hepatol. Gastroenterolog. (IF 2.7) Pub Date : 2024-02-01 Yan An, Yechen Xia, Zhengyang Wang, Guang-Zhi Jin, Mingyi Shang
Hepatocellular carcinoma (HCC) is the third leading cause of cancer deaths worldwide. Dysregulation of ribosome biogenesis increases the risk of cancer. RPF2 (ribosome production factor 2 homolog), a member of the BRIX family, is involved in ribosome biogenesis. However, the biological functions of RPF2 in HCC remain unclear. This study aims to evaluate the function of RPF2 and its clinical significance
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Exploring the combined effects of MTTP gene polymorphisms in chronic hepatitis C patients with hepatic steatosis Clin. Res. Hepatol. Gastroenterolog. (IF 2.7) Pub Date : 2024-01-28 Thamiris Vaz Gago Prata, Victória Gonçalves de Paula, Lhays Ozório Passos, Vitória Luiza Batalhoti Brogiato, Gustavo Manoel Ferreira, Caroline Manchiero, Bianca Peixoto Dantas, Débora Bignotto Rosane Battaglia, Gerusa Maria Figueiredo, Fátima Mitiko Tengan, Mariana Cavalheiro Magri
Abstract not available
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Aspirin for non alcoholic fatty liver disease: Promising but inconclusive–A letter to the editor Clin. Res. Hepatol. Gastroenterolog. (IF 2.7) Pub Date : 2024-01-23 Hafiz Muhammad Sohaib Hayat, Hamza Naeem
Abstract not available
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A comparison analysis of the somatic mutations in early-onset gastric cancer and traditional gastric cancer Clin. Res. Hepatol. Gastroenterolog. (IF 2.7) Pub Date : 2024-01-20 Xiaoxuan Han, Xiaoxiao Jia, Chong sheng, Mengyuan Li, Jinxi Han, Kaijuan Wang
Background Early onset gastric cancer (EOGC) has been on the rise in recent years and differs slightly in pathology from traditional gastric cancer (TGC). Somatic mutations have an essential role in the development of gastric cancer. We aimed to investigate these two types of gastric cancers at the level of somatic mutations and to further understanding of gastric cancer development. Methods Somatic
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Post-colonoscopy colorectal cancer: A population-based cohort study of fecal occult blood test-positive colonoscopies Clin. Res. Hepatol. Gastroenterolog. (IF 2.7) Pub Date : 2024-01-20 Bernard Denis, Alice Bertolaso, Isabelle Gendre, Philippe Perrin, Karima Hammas
Background Data on post-colonoscopy colorectal cancers (PCCRCs) after fecal occult blood test (FOBT)-positive colonoscopies is scarce (guaiac-based (gFOBT) or fecal immunochemical test (FIT)). Aims Evaluate the prevalence and characteristics of PCCRCs in the French gFOBT CRC screening program. Methods Retrospective population-based cohort study of all gFOBT-positive colonoscopies performed among individuals
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Association of composite dietary antioxidant index and muscle mass in individuals with metabolic associated fatty liver disease Clin. Res. Hepatol. Gastroenterolog. (IF 2.7) Pub Date : 2024-01-15 Jing Guo, Lin Shi, Yan Sun
Background There is mounting evidence indicating the association between oxidative stress and the detrimental effect it poses on muscle mass. However, the crucial interplay between the Composite Dietary Antioxidant Index (CDAI), a key metric of antioxidant-rich diets, and the occurrence of muscle loss has remained largely unexplored. Hence, in this study, we aim to investigate the potential relationship
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Predicting cancer-specific mortality in T1/2 hepatocellular carcinoma after radiofrequency ablation by competing risk nomogram: A population-based analysis Clin. Res. Hepatol. Gastroenterolog. (IF 2.7) Pub Date : 2024-01-12 Qifan He, Yue Xiong, Pengcheng Xia, Xiaoyu Yang, Yihui Yu, Zhonghua Chen
Background Radiofrequency ablation (RFA) is one of the primary treatment methods for T1/2 hepatocellular carcinoma (HCC), but the risk factors after RFA remain controversial. This study aims to identify the key factors associated with cancer-specific mortality (CSM) in patients with T1/2 HCC after RFA using competing risk analysis and to establish a prognostic nomogram for improved clinical management
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A simple cap-assistant method to removal fishbone embedded in the cervical esophageal wall Clin. Res. Hepatol. Gastroenterolog. (IF 2.7) Pub Date : 2024-01-11 Si-Di Wang, Ting-Ting Cao, Zhu Wang
Abstract not available
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Enhanced therapeutic outcomes with atezolizumab-bevacizumab and SIRT combination compared to SIRT alone in unresectable HCC: A promising approach for improved survival Clin. Res. Hepatol. Gastroenterolog. (IF 2.7) Pub Date : 2024-01-06 Amel Mejait, Charles Roux, Marine Soret, Edouard Larrey, Mathilde Wagner, Jean Charles Bijot, Charlotte Lussey-Lepoutre, Dominique Thabut, Claire Goumard, Philippe Maksud, Manon Allaire
Background Integrating immunotherapy with locoregional therapies marks a significant milestone in the realm of hepatocellular carcinoma (HCC) treatment . This study aimed to assess the impact of addition of Atezolizumab-Bevacizumab (AtezoBev) on the outcome patients treated with SIRT. Methods We conducted a study that included all Child-Pugh A HCC treated with SIRT since 2017. We examined the effects
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Geriatric factors associated with overall survival in older patients with metastatic colorectal cancer Clin. Res. Hepatol. Gastroenterolog. (IF 2.7) Pub Date : 2024-01-03 Véronique Dardaine, Mathilde Cancel, Kaggwa Inyambo, Julie Biogeau, Carine Sauger, Thierry Lecomte, Etienne Dorval
Advanced age in patients with colorectal cancer is a factor of poor prognosis, but little is known about geriatric factors associated with survival and chemotherapy prescription in frail elderly patients. Our research sought to investigate these factors in older patients with metastatic colorectal cancer (mCRC). Patients and methods patients aged ≥75 years, who were treated for mCRC and have had a
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Comparison between the effect of Empagliflozin and Pioglitazone added to metformin in patients with type 2 diabetes and nonalcoholic fatty liver disease Clin. Res. Hepatol. Gastroenterolog. (IF 2.7) Pub Date : 2023-12-29 Laya Hooshmand Gharabagh, Ali Shargh, Mohammad Reza Mohammad Hosseini Azar, Ayda Esmaeili
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Bacteroides thetaiotaomicron and its inactivated bacteria ameliorate colitis by inhibiting macrophage activation Clin. Res. Hepatol. Gastroenterolog. (IF 2.7) Pub Date : 2023-12-28 Sikong Yinhe, Li Lixiang, Li Yan, Gu Xiang, Li Yanqing, Zuo Xiuli
Background Studies have demonstrated that Bacteroides thetaiotaomicron (BT) has protective effect against colon inflammation in murine models. Macrophages play an important role in gut immunity. However, the specific mechanisms of BT on macrophage are still unelucidated. Thus, our study investigates the anti-inflammatory effect of BT and its heat-treated inactivated bacteria on experimental colitis
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Fecal Incontinence Subtype Assessment (FI-SA): Validation of a new tool to distinguish among subtypes of fecal incontinence Clin. Res. Hepatol. Gastroenterolog. (IF 2.7) Pub Date : 2023-12-28 Audrey Julienne, Guillaume Gourcerol, Gérard Amarenco, Nicolas Turmel, Anne-Marie Leroi, Charlotte Desprez
Purpose Three subtypes of fecal incontinence (FI) are described in the literature: urge, mixed and passive FI, but the relevance of this classification remains unknown. To our knowledge, no questionnaire has been validated in a general population of patients with FI to classify patients between the different subtypes of FI. The aim of the present study was to validate the Fecal Incontinence Subtype
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Development and validation of a novel nomogram model to assess the risk of gastric contents in outpatients undergoing elective sedative gastrointestinal endoscopy procedures Clin. Res. Hepatol. Gastroenterolog. (IF 2.7) Pub Date : 2023-12-28 Yuqing Yan, Yuzhan Jin, Yuanyuan Cao, Chen Chen, Xiuxiu Zhao, Huaming Xia, Libo Yan, Yanna Si, Jianjun Zou
Background Gastric contents may contribute to patients' aspiration during anesthesia. Ultrasound can accurately assess the risk of gastric contents in patients undergoing sedative gastrointestinal endoscopy (GIE) procedures, but its efficiency is limited. Therefore, developing an accurate and efficient model to predict gastric contents in outpatients undergoing elective sedative GIE procedures is greatly
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Population characteristics, healthcare pathways and outcomes of patients with cirrhosis hospitalized with overt hepatic encephalopathy in France: A study of the French Hospital‐Discharge Database Clin. Res. Hepatol. Gastroenterolog. (IF 2.7) Pub Date : 2023-12-27 Dominique Thabut, Julia Roux, Philippe Sultanik, Cheikh Tamberou, Pierre-Louis Prost, Hervé Hagège
Hepatic encephalopathy (HE) is a severe complication of cirrhosis, independently associated with a poor survival. The objectives of this study were to describe the prevalence of overt hepatic encephalopathy (OHE) requiring hospitalization, and the healthcare pathways and outcomes of patients hospitalized for OHE in France. Data from the French Hospital‐Discharge Database (Programme de Medicalisation
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Metabolism-related signalling pathways involved in the pathogenesis and development of metabolic dysfunction-associated steatotic liver disease Clin. Res. Hepatol. Gastroenterolog. (IF 2.7) Pub Date : 2023-12-23 Cheng Xie, Kaiyu Liu, Yixin Xie, Shun Liu, Bai Ji
Metabolic dysfunction-associated steatotic liver disease (MASLD) which formerly known as non-alcoholic fatty liver disease (NAFLD) is one of the causes of liver cirrhosis. Currently, a growing number of liver cirrhosis cases develop on the basis of MASLD, and the pathogenesis of MASLD remains unclear. This paper reviews the research progress on the involvement of different metabolism-related signalling
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Gut dysbiosis in Crohn's disease: Never so close to solving the chicken-and-egg enigma: Commentary to “Gut microbiome composition is associated with future onset of Crohn's disease in healthy first-degree relatives, by Raygoza Garay JA et al., Gastroenterology 2023” Clin. Res. Hepatol. Gastroenterolog. (IF 2.7) Pub Date : 2023-12-23 Nathan Grellier, Harry Sokol, Philippe Seksik
Crohn's disease (CD) is a chronic disease of the digestive tract whose pathogenesis remains not fully understood. Several studies have implicated the gut microbiota as a key player in the onset of gut inflammation. However, most of the data is based on case-control studies comparing patients with established disease with controls, usually healthy individuals. The study by Raygoza Garay and colleagues
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The regulatory effect of lncRNA LINC00943 on the progression of hepatocellular carcinoma and its relationship with clinicopathological features Clin. Res. Hepatol. Gastroenterolog. (IF 2.7) Pub Date : 2023-12-23 Xiaoan Qi, Liang Liu
Background The risk factors for the pathogenesis of HCC are highly variable, and the prognosis of patients is very unsatisfactory. In this study, we investigated the regulatory effect of LINC00943 on HCC progression and its relationship with clinicopathological features. Methods LINC00943 level in HCC tissues and cell specimens was verified by RT-qPCR. The pathologic significance of LINC00943 in the
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Reply to “Epidemiology, treatment and burden of Wilson disease in France: A 10-year analysis of the National health insurance database” Clin. Res. Hepatol. Gastroenterolog. (IF 2.7) Pub Date : 2023-12-14 Mickael Alexandre Obadia, France Woimant, Philippe Tuppin, Dominique Debray, Aurelia Poujois
Abstract not available
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Good outcome of liver transplantation in patients with pre-existing renal cell carcinoma Clin. Res. Hepatol. Gastroenterolog. (IF 2.7) Pub Date : 2023-12-13 G. Lassailly, M. Ningarhari, J. Dumortier, C. Lafforgue, S. Bouye, M.El Amrani, G. Lebuffe, A. Villers, S Truant, P. Mathurin, A. Louvet, O Boillot, E Boleslawski, S. Dharancy
The presence of a pre-existing or recent extra-hepatic solid tumor was considered for a long time as an absolute contraindication to liver transplantation, by fear of futility with an unacceptable increase in non-liver-related mortality. However, cancer-related mortality in solid malignancies is heterogeneous, and experts suggest that case-by-case multidisciplinary decisions should be made. Here, we