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Altered functional connectivity strength of primary visual cortex in subjects with thyroid-associated ophthalmopathy. Neuroreport (IF 1.7) Pub Date : 2024-04-17 Chen-Xing Qi, Zhi Wen, Xin Huang
Our objective was to explore the disparities in the intrinsic functional connectivity (FC) patterns of primary visual cortex (V1) between patients with thyroid-associated ophthalmopathy (TAO) and healthy controls (HCs) utilizing resting-state functional MRI. Twenty-one patients with TAO (14 males and 7 females; mean age: 54.17 ± 4.83 years) and 21 well-matched HCs (14 males and 7 females; mean age:
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Egr1 promotes Nlrc4-dependent neuronal pyroptosis through phlda1 in an in-vitro model of intracerebral hemorrhage. Neuroreport (IF 1.7) Pub Date : 2024-04-17 Jian Wang, Diheng Gu, Ke Jin, Hualong Shen, Yaohua Qian
Intracerebral hemorrhage (ICH) is a fatal brain injury, but the current treatments for it are inadequate to reduce the severity of secondary brain injury. Our study aims to explore the molecular mechanism of Egr1 and Phlda1 in regulating hemin-induced neuronal pyroptosis, and hope to provide novel therapeutic targets for ICH treatment. Mouse hippocampal neuron cells treated with hemin were used to
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The impact of physical exercise on hippocampal atrophy in mild cognitive impairment and Alzheimer's disease: a meta-analysis. Neuroreport (IF 1.7) Pub Date : 2024-04-12 Gavin T Kress, Emily S Popa, David A Merrill, Jennifer E Bramen, Prabha Siddarth
Physical activity (PA) is a promising therapeutic for Alzheimer's disease (AD). Only a handful of meta-analyses have studied the impact of PA interventions on regional brain volumes, and none to date has solely included studies on effect of PA on regional brain volumes in individuals with cognitive impairment (CI). In this meta-analysis, we examined whether there is support for the hypothesis that
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The polysaccharides from Balanophora polyandra enhanced neuronal autophagy to ameliorate brain function decline in natural aging mice through the PI3K/AKT/mTOR signaling pathway. Neuroreport (IF 1.7) Pub Date : 2024-04-10 Wenyan Zhong, Jingjing Chen, Yumin He, Li Xiao, Chengfu Yuan
The decline of aging brain neurons is the main cause of various neurodegenerative disease. This study aimed to examine the impact of Balanophora polyandra polysaccharides (BPP) against aging related neuronal deterioration. C57BL/6 mice were fed with regular feed for 27 months to establish a natural aging mouse model. From 3 months of age, mice in the drug-treated group were respectively fed with feed
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ADAMTS13 deficiency exacerbates neuroinflammation by targeting matrix metalloproteinase-9 in ischemic brain injury. Neuroreport (IF 1.7) Pub Date : 2024-04-10 Hongxiang Jiang, Juntao Hu, Peidong He, Yu Wu, Fei Li, Qianxue Chen
Our design aimed to explore the potential involvement of matrix metalloproteinase-9 (MMP-9) in the inflammatory response associated with acute ischemic stroke (AIS). We also aimed to preliminarily examine the potential impact of a disintegrin-like and metalloprotease with thrombospondin type I repeats-13 (ADAMTS13) on MMP-9 in AIS. We conducted oxygen-glucose deprivation models of microglia cells and
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The association between glymphatic system dysfunction and alterations in cerebral function and structure in patients with white matter hyperintensities. Neuroreport (IF 1.7) Pub Date : 2024-04-10 Zhang Zhi, Xiao Liang, Muhua Huang, Lin Wu, Fuqing Zhou
The objective of this study is to explore the relationship between the glymphatic system and alterations in the structure and function of the brain in white matter hyperintensity (WMH) patients. MRI data were collected from 27 WMH patients and 23 healthy controls. We calculated the along perivascular space (ALPS) indices, the anterior corner distance of the lateral ventricle, and the width of the third
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Altered expression of transfer RNAs and their possible roles in brain white matter injury. Neuroreport (IF 1.7) Pub Date : 2024-04-08 Lingyi Huang, Ding Bai, Xiaojuan Su
Transfer RNAs (tRNAs) can regulate cell behavior and are associated with neurological disorders. Here, we aimed to investigate the expression levels of tRNAs in oligodendrocyte precursor cells (OPCs) and their possible roles in the regulation of brain white matter injury (WMI). Newborn Sprague-Dawley rats (postnatal day 5) were used to establish a model that mimicked neonatal brain WMI. RNA-array analysis
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Electroacupuncture reduces oxidative stress response and improves secondary injury of intracerebral hemorrhage in rats by activating the peroxisome proliferator-activated receptor-γ/nuclear factor erythroid2-related factor 2/γ-glutamylcysteine synthetase pathway. Neuroreport (IF 1.7) Pub Date : 2024-04-08 Weigang Luo, Wei Bu, Hequn Chen, Wanhu Liu, Xudong Lu, Guisong Zhang, Cuicui Liu, Xiaohui Li, Huiling Ren
Intracerebral hemorrhage (ICH) is a severe stroke subtype. Secondary injury is a key factor leading to neurological deficits after ICH. Electroacupuncture (EA) can improve the neurological function after ICH, however, its internal mechanism is still unclear. The aim of this study is to investigate whether EA could ameliorate secondary injury after ICH through antioxidative stress and its potential
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Differential changes in Wnt7 and Dkk1 levels in astrocytes exposed to glutamate or TNFα. Neuroreport (IF 1.7) Pub Date : 2024-04-08 Lizbeth García-Velázquez, Reem Alobayan, Denisse Morales-Moreno, Evangelina Ávila-Muñoz, Clorinda Arias
Wnt signaling plays an important role in adult brain function, and its dysregulation has been implicated in the loss of neuronal homeostasis. Despite the existence of many studies on the participation of the Wnt pathway in adult neurons, its regulation in astrocytes has been scarcely explored. Several reports point to the presence of Wnt ligands in astrocytes and their possible impact on neuronal plasticity
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Emodin relieves morphine-stimulated BV2 microglial activation and inflammation through the TLR4/NF-κB/NLRP3 pathway. Neuroreport (IF 1.7) Pub Date : 2024-04-08 Shimei Li, Songjiang Tang, Lina Dai, Zhonglu Jian, Xi Li
The objective of this study is to disclose the role of emodin, a natural anthraquinone derivative that has been proposed to suppress microglial activation and inflammation, in morphine tolerance. Here, cell counting kit-8 method assayed the viability of BV2 microglial cells treated by ascending concentrations of emodin. In emodin-pretreated BV2 microglial cells challenged with morphine with or without
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Dynamically changed HSP70 after reperfusion following cerebral infarction in human and rats: correlation with p38 MAPK. Neuroreport (IF 1.7) Pub Date : 2024-03-27 Zhilan Tu, Pengpeng Jin, Qinghua Wang, Yanlin Feng, Xinjuan Chu, Lin Fu, Shuangxing Hou, Weiwei Li
We aimed to clarify the correlation between dynamic change of blood HSP70 and the prognosis of thrombolysis in human and rats, so as to explain the neuroprotection and early warning role of HSP70 in cerebral ischemia-reperfusion. Forty-two patients with acute ischemic stroke were divided into two groups according to the time from onset to thrombolytic therapy: 0 h-3 h (27 patients) and 3-4.5 h group
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Electroacupuncture promotes macrophage/microglial M2 polarization and suppresses inflammatory pain through AMPK. Neuroreport (IF 1.7) Pub Date : 2024-03-20 Fu-Bei Nan, Yi-Xiao Gu, Jun-Lu Wang, Shuang-Dong Chen
Inflammatory pain, the most prevalent disease globally, remains challenging to manage. Electroacupuncture emerges as an effective therapy, yet its underlying mechanisms are not fully understood. This study investigates whether adenosine 5'-monophosphate (AMP)-activated protein kinase (AMPK)-regulated silent information regulator 1 (SIRT1) contributes to electroacupuncture's antinociceptive effects
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Annexin A1 conveys neuroprotective function via inhibiting oxidative stress in diffuse axonal injury of rats. Neuroreport (IF 1.7) Pub Date : 2024-03-15 Fengwei Zheng, Weixin Li, Shaobo Su, Qiaoyan Hui
Diffuse axonal injury (DAI) is a critical pathological facet of traumatic brain injury (TBI). Oxidative stress plays a significant role in the progress of DAI. Annexin A1 (AnxA1) has been demonstrated to benefit from recovery of neurofunctional outcomes after TBI. However, whether AnxA1 exhibits neuronal protective function by modulating oxidative stress in DAI remains unknown. Expression of AnxA1
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Nerolidol reduces depression-like behavior in mice and suppresses microglia activation by down-regulating DNA methyltransferase 1. Neuroreport (IF 1.7) Pub Date : 2024-03-15 Guangcai Zhang, Xiaohui Zhou, Qifan Feng, Weihua Ke, Jiahui Pan, Haiying Zhang, Yixian Luan, Beibei Lei
Modern medicine has unveiled that essential oil made from Aquilaria possesses sedative and hypnotic effects. Among the chemical components in Aquilaria, nerolidol, a natural sesquiterpene alcohol, has shown promising effects. This study aimed to unravel the potential of nerolidol in treating depression. Chronic unpredictable mild stress (CUMS) was utilized to induce depression-like behavior in mice
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Inhibition of SIRT1 in the nucleus accumbens attenuates heroin addiction-related behavior by decreasing D1 neuronal autophagy. Neuroreport (IF 1.7) Pub Date : 2024-03-15 Yanyan Huang, Meijun Liu, Zhiyao Zheng, Ruiping Lu, Chunlu Li, Min Su, Yixin Li, Baijuan Xia
This study aimed to investigate the effects of SIRT1 modulation on heroin addiction-like behavior and its possible biological mechanisms. Wild-type C57BL/6J and Sirt1loxp/loxpD1-Cre mice were used in this experiment, and Sirt1loxp/loxpD1-Cre(-) mice were used as a control for conditional knockout mice. Mice were divided into saline control and heroin-dependent groups. Behavioral methods were used to
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Protective effects of human urinary kallidinogenase against corticospinal tract damage in acute ischemic stroke patients. Neuroreport (IF 1.7) Pub Date : 2024-03-12 Peifang Li, Honglin Lu, Xiaoman Shi, Jiajia Yan, Lixia Zhou, Jipeng Yang, Binbin Wang, Yanying Zhao, Luji Liu, Yipu Zhu, Lei Xu, Xiaoli Yang, Xudong Su, Yi Yang, Tong Zhang, Li Guo, Xiaoyun Liu
This study aimed to assess the effects of human urinary kallidinogenase (HUK) on motor function outcome and corticospinal tract recovery in patients with acute ischemic stroke (AIS). This study was a randomized, controlled, single-blinded trial. Eighty AIS patients were split into two groups: the HUK and control groups. The HUK group was administered HUK and standard treatment, while the control group
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Corpus callosum and cerebellum participate in semantic dysfunction of Parkinson's disease: a diffusion tensor imaging-based cross-sectional study. Neuroreport (IF 1.7) Pub Date : 2024-03-11 Hang Liu, Yuke Zhong, Guohui Liu, Huahua Su, Zhihui Liu, Jiahao Wei, Lijuan Mo, Changhong Tan, Xi Liu, Lifen Chen
Language dysfunction is common in Parkinson's disease (PD) patients, among which, the decline of semantic fluency is usually observed. This study aims to explore the relationship between white matter (WM) alterations and semantic fluency changes in PD patients. 127 PD patients from the Parkinson's Progression Markers Initiative cohort who received diffusion tensor imaging scanning, clinical assessment
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CXCL13/CXCR5 promote chronic postsurgical pain and astrocyte activation in rats by targeting NLRP3. Neuroreport (IF 1.7) Pub Date : 2024-03-08 Hongda Yi, Bin Zhu, Caihong Zheng, Zhenyang Ying, Mei Cheng
Chronic postsurgical pain (CPSP) with high incidence negatively impacts the quality of life. X-C motif chemokine 13 (CXCL13) has been associated with postsurgery inflammation and exacerbates neuropathic pain in patients with CPSP. This study was aimed to illustrate the relationship between CXCL13 and nod-like receptor protein-3 (NLRP3), which is also involved in CPSP. A CPSP model was constructed by
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Effects of finger pinch motor imagery on short-latency afferent inhibition and corticospinal excitability. Neuroreport (IF 1.7) Pub Date : 2024-03-08 Kento Nakashoji, Atsushi Sasaki, Naotsugu Kaneko, Taishin Nomura, Matija Milosevic
Motor imagery is a cognitive process involving the simulation of motor actions without actual movements. Despite the reported positive effects of motor imagery training on motor function, the underlying neurophysiological mechanisms have yet to be fully elucidated. Therefore, the purpose of the present study was to investigate how sustained tonic finger-pinching motor imagery modulates sensorimotor
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Neuroprotective effect of green tea extract (-)-epigallocatechin-3-gallate in a preformed fibril-induced mouse model of Parkinson's disease. Neuroreport (IF 1.7) Pub Date : 2024-03-08 Jianing Shen, Junhua Xie, Liyuan Ye, Jian Mao, Shihao Sun, Weiwei Chen, Sijia Wei, Sisi Ruan, Linhai Wang, Hangcui Hu, Jingjing Wei, Yao Zheng, Zhouyan Xi, Ke Wang, Yan Xu
Parkinson's disease (PD) is the second most common neurodegenerative disease characterized by the progressive degeneration of dopaminergic neurons in the substantia nigra (SN). The main bioactive component of green tea polyphenols (-)-epigallocatechin-3-gallate (EGCG) exerts protective effects against diseases such as neurodegenerative diseases and cancer. Therefore, this study investigated the effect
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Role of LGL1 in cerebellar primordium of embryonic mice. Neuroreport (IF 1.7) Pub Date : 2024-03-04 Congzhe Hou, Aizhen Zhang, Yecheng Jin, Chao Ye, Runze Li, Zhenhua Liu, Jiangang Gao
Lethal giant larvae 1 (LGL1) is originally recognized as a tumor suppressor, implicated in maintaining cell polarity in Drosophila and mammalian cells. Cell polarity plays a crucial role in tumorigenesis. We previously established Pax2-LGL1-/- conditional knockout mice but did not focus on the tumorigenesis in cerebellar primordium. HE staining was used to detect the morphological structure of the
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Impaired autophagic flux in the human brain after traumatic brain injury. Neuroreport (IF 1.7) Pub Date : 2024-03-04 Jiadong Lang, Boyu Sun, Shiyao Feng, Guozhu Sun
Emerging evidence indicates that dysfunctional autophagic flux significantly contributes to the pathology of experimental traumatic brain injury (TBI). The current study aims to clarify its role post-TBI using brain tissues from TBI patients. Histological examinations, including hematoxylin and eosin, Nissl staining, and brain water content analysis, were employed to monitor brain damage progression
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Functional connectivity between the habenula and posterior default mode network contributes to the response of the duloxetine effect in major depressive disorder. Neuroreport (IF 1.7) Pub Date : 2024-03-04 Yanru Wu, Zhaosong Chu, Xianyu Chen, Yun Zhu, Xiufeng Xu, Zonglin Shen
This study aims to investigate the functional connectivity (FC) changes of the habenula (Hb) among patients with major depressive disorder (MDD) after 12 weeks of duloxetine treatment (MDD12). Patients who were diagnosed with MDD for the first time and were drug-naïve were recruited at baseline as cases. Healthy controls (HCs) matched for sex, age, and education level were also recruited at the same
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Frequency effects can modulate the neural correlates of prosodic processing in Mandarin. Neuroreport (IF 1.7) Pub Date : 2024-03-04 Zhongpei Zhang
In tonal languages, tone perception involves the processing of both acoustic and phonological information conveyed by tonal signals. In Mandarin, in addition to four canonical full tones, there exists a group of weak syllables known as neutral tones. This study aims to investigate the impact of lexical frequency effects and prosodic information associated with neutral tones on the auditory representation
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Progesterone induces neuroprotection associated with immune/inflammatory modulation in experimental traumatic brain injury. Neuroreport (IF 1.7) Pub Date : 2024-03-01 Ziwei Zhou, Yadan Li, Ruilong Peng, Mingming Shi, Weiwei Gao, Ping Lei, Jianning Zhang
An imbalance of immune/inflammatory reactions aggravates secondary brain injury after traumatic brain injury (TBI) and can deteriorate clinical prognosis. So far, not enough therapeutic avenues have been found to prevent such an imbalance in the clinical setting. Progesterone has been shown to regulate immune/inflammatory reactions in many diseases and conveys a potential protective role in TBI. This
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Application of sensory nerve quantitative tests to analyze the subtypes of motor disorders in Parkinson's disease. Neuroreport (IF 1.7) Pub Date : 2024-03-01 Hongxue Tian, Yongsheng Yuan, Kezhong Zhang
This study investigated the sensory nerve function in people with different subtypes of Parkinson's disease (PD), which included the tremor-dominant (TD) group (n = 30), postural instability and gait disorder (PIGD) group (n = 33), and healthy-controls (HC) group (n = 33). Sural nerve's current perception threshold (CPT) and pain tolerance threshold (PTT) in both feet were measured at different frequencies
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Beyond boundaries: investigating shared and divergent connectivity in the pre-/postcentral gyri and supplementary motor area. Neuroreport (IF 1.7) Pub Date : 2024-02-19 Adnan A S Alahmadi
This study aimed to comprehensively investigate the functional connectivity of key brain regions involved in motor and sensory functions, namely the precentral gyrus, postcentral gyrus and supplementary motor area (SMA). Using advanced MRI, the objective was to understand the neurophysiological integrative characterizations of these regions by examining their connectivity with eight distinct functional
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Gender differences in pedestrian hazard perception: evidence from an event-related potential study. Neuroreport (IF 1.7) Pub Date : 2024-02-19 Peng Zhu, Min Ma
Gender differences in pedestrian hazard perception were investigated using the event-related potential technique.
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Sophora flavescens alcohol extract ameliorates insomnia and promotes PI3K/AKT/BDNF signaling transduction in insomnia model rats. Neuroreport (IF 1.7) Pub Date : 2024-02-19 Yanyan Wu, Chenhang Yao, Lan Zhang, Guoqing Wu
Active ingredient of Sophora flavescens is reported to promote non-rapid eye movement (NREM) sleep. However, the role of Sophora flavescens alcohol extract in insomnia is elusive, which is addressed in this study, together with the exploration on its potential mechanism. An insomnia model of rats was established by para-chlorophenylalanine induction and further treated with SFAE or Zaoren Anshen capsule
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Adaptation-induced sharpening of orientation tuning curves in the mouse visual cortex. Neuroreport (IF 1.7) Pub Date : 2024-02-19 Afef Ouelhazi, Vishal Bharmauria, Stéphane Molotchnikoff
Orientation selectivity is an emergent property of visual neurons across species with columnar and noncolumnar organization of the visual cortex. The emergence of orientation selectivity is more established in columnar cortical areas than in noncolumnar ones. Thus, how does orientation selectivity emerge in noncolumnar cortical areas after an adaptation protocol? Adaptation refers to the constant presentation
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Neural correlates of processing active and passive sentences: proficiency-dependent event-related potential evidence in Chinese English foreign language learners. Neuroreport (IF 1.7) Pub Date : 2024-02-19 Tao Wang, Keyi Yin, Xing Wang, Man Wang
We explored whether and to what extent the neural mechanisms of second language sentence processing resemble those of native speakers by investigating the temporal dynamics of syntactic processing in terms of active or passive voice in reading English sentences by Chinese English Foreign Language (EFL) learners with high or low English proficiency. Participants were divided into two groups based on
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Analysis of the lncRNA-miRNA-mRNA network to explore the regulation mechanism in human traumatic brain injury. Neuroreport (IF 1.7) Pub Date : 2024-02-19 Xuefei Shao, Maosong Zhang, Jincheng Fang, Ruixiang Ge, Yue Su, Hongbing Liu, Daojin Zhang, Qifu Wang
Traumatic brain injury (TBI) refers to brain dysfunction with or without traumatic structural injury induced by an external force. Nevertheless, the molecular mechanism of TBI remains undefined. Differentially expressed (DE) lncRNAs, DEmRNAs and DEmiRNAs were selected between human TBI tissues and the adjacent histologically normal tissue by high-throughput sequencing. Gene ontology enrichment analysis
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Altered dynamic and static brain activity and functional connectivity in COVID-19 patients: a preliminary study. Neuroreport (IF 1.7) Pub Date : 2024-02-02 Mingxing Han, Chunni He, Tianping Li, Qinglong Li, Tongpeng Chu, Jun Li, Peiyuan Wang
This study aimed to investigate the effects of COVID-19 on brain functional activity through resting-state functional MRI (rs-fMRI). fMRI scans were conducted on a cohort of 42 confirmed COVID-19-positive patients and 46 healthy controls (HCs) to assess brain functional activity. A combination of dynamic and static amplitude of low-frequency fluctuations (dALFF/sALFF) and dynamic and static functional
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Sortilin inhibition in microglial cells cannot alleviate ischemia and hypoxia-induced neuronal injury in co-culture. Neuroreport (IF 1.7) Pub Date : 2024-02-02 Shuang Long, Zhao Liu, Yan Wang
Sortilin is a single-pass type I transmembrane protein which can bind to various cargo proteins, regulating their surface location, secretion, or degradation in lysosomes. In our previous study, we found that sortilin can regulate progranulin expression by transporting it to lysosomes and reduce neuronal cell injury in hypoxia-ischemia, but the expression and function of sortilin in microglial cells
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Auditory influence on stickiness perception: an fMRI study of multisensory integration. Neuroreport (IF 1.7) Pub Date : 2024-02-02 In-Seon Lee, Jae-Hwan Kang, Junsuk Kim
This study explored how the human brain perceives stickiness through tactile and auditory channels, especially when presented with congruent or incongruent intensity cues. In our behavioral and functional MRI (fMRI) experiments, we presented participants with adhesive tape stimuli at two different intensities. The congruent condition involved providing stickiness stimuli with matching intensity cues
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Electroacupuncture alleviates streptozotocin-induced diabetic neuropathic pain via suppressing phosphorylated CaMKIIα in rats. Neuroreport (IF 1.7) Pub Date : 2024-02-02 Siyi Li, Yinmu Zheng, Yurong Kang, Xiaofen He, Yu Zheng, Minjian Jiang, Xinnan Xu, Liqian Ma, Xiaoxiang Wang, Kunlong Zhang, Xiaomei Shao, Jianqiao Fang, Yongliang Jiang
Diabetic neuropathic pain (DNP) is a frequent complication of diabetes. Calcium/calmodulin-dependent protein kinase II α (CaMKIIα), a multi-functional serine/threonine kinase subunit, is mainly located in the surface layer of the spinal cord dorsal horn (SCDH) and the primary sensory neurons in dorsal root ganglion (DRG). Numerous studies have indicated electroacupuncture (EA) takes effect in various
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Effects of hazard type and confidence level on hazard perception in young male drivers: an ERP study. Neuroreport (IF 1.7) Pub Date : 2024-02-02 Long Sun, Wen-Jing Hu, Liang Cheng, Chang-Lu Zhang
Hazard perception refers to a driver's ability to identify potential hazards on the road. Although studies have shown that overconfidence affects drivers' ability to perceive hazards, the neural processing of hazard perception in overconfident drivers under different hazard types has rarely been investigated. A mixed experimental design of 2 (hazard type: hazards, no hazards) × 2 (driver group: overconfident
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Myelin basic proteins charge isomers interact differently with the peptidyl arginine deiminase-2. Neuroreport (IF 1.7) Pub Date : 2024-01-31 Nino Mamulashvili, Marika Chikviladze, Lali Shanshiashvili, David Mikeladze
The deamination of arginine and its conversion to citrulline is a modification observed in positively charged proteins such as histones or myelin basic protein (MBP). This reaction is catalyzed by peptidyl arginine deiminase (PAD), whose abnormal activation is associated with autoimmune diseases like rheumatoid arthritis and multiple sclerosis. However, the mechanisms that trigger PAD activation and
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GSK-3β inhibitor TWS119 promotes neuronal differentiation after hypoxic-ischemic brain damage in neonatal rats. Neuroreport (IF 1.7) Pub Date : 2024-01-31 Limin Gao, Shuqiang Gao, Hailei Shan, Yanqiu Wu, Qili Zhou
Brain injury in preterm infants is a major cause of disability and mortality in children. GSK-3β is a common pathogenic factor for cognitive dysfunction and involves in neuronal proliferation and differentiation. However, GSK-3β affected neuronal differentiation and its molecular pathogenesis after hypoxic-ischemic brain damage in neonatal rats remains unclear. This study investigated the effects of
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Imperatorin inhibits oxidative stress injury and neuroinflammation via the PI3K/AKT signaling pathway in the MPTP-induced Parkinson's disease mouse. Neuroreport (IF 1.7) Pub Date : 2024-01-31 Li Liu, Lei Jiang, Jinglan Zhang, Yan Ma, Min Wan, Xueqing Hu, Lian Yang
Parkinson's disease (PD) is a disorder of neurodegeneration. Imperatorin is an active natural furocoumarin characterized by antioxidant, anti-inflammatory, and potent vasodilatory properties. Therefore, we aimed to investigate the biological functions of imperatorin and its mechanisms against PD progression. C57BL/6 mice were intraperitoneally injected with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine
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Effects of motion type on motion-onset and steady-state visual evoked potentials: rotation vs. flicker. Neuroreport (IF 1.7) Pub Date : 2024-01-31 BingBing Yu, Li Sui
The underlying mechanisms of information processing for two basic motion types, rotation and flicker, are not fully understood. Rotational and flickering animations at four speeds - 7 frames per second (fps), 8 fps, 11 fps, and 12 fps, respectively - are presented as visual stimuli. The motion-onset visual evoked potentials (VEPs) and steady-state VEPs (SSVEP) elicited by these motion stimuli were
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Alpha-lipoic acid (ALA) ameliorates early brain injury after subarachnoid hemorrhage in Sprague-Dawley (SD) rats via inhibiting STING-NLRP3 inflammatory signaling. Neuroreport (IF 1.7) Pub Date : 2024-01-15 Chunnan Lin, Chunliu He, Liuqing Li, Yongqiang Liu, Liangang Tang, Zepeng Ni, Naichong Zhang, Tinghai Lai, Xiaohong Chen, Xiangyu Wang
Neuroinflammation is intimately associated with poor prognosis in patients with subarachnoid hemorrhage (SAH). Alpha-lipoic acid (ALA), a disulfide antioxidant, has been shown to be neuroprotective in an in vivo model of neurological injury; however, the role of ALA in SAH has never been evaluated. In this study, the Sprague-Dawley rats SAH model was induced by endovascular perforation method. ALA
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Histomorphological analysis of perfusion parameters and CNS lymphatic vessels in mice: an experimental method study. Neuroreport (IF 1.7) Pub Date : 2024-01-12 Xiao-Ge Liu, Qian Hua, Tian-Tian Peng, Ke-Xin Chang, Chen-Geng Deng, Jia-Ni Zhang, Xin-Yuan Yan, Chun-Xiang Wang, Ke Yan, Qing-Yuan Cai, Yan Tan
To investigate the distribution and characteristics of lymphatic vessels within the central nervous system, we focus on the meninges of the spinal cord and brain parenchyma in mice. Additionally, we aim to provide experimental methods for obtaining optimal imaging and clear structures of lymphatic vessels, while optimizing the perfusion parameters to improve histomorphological quality. Male C57BL/6J
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Hispolon inhibits neuronal ferroptosis by promoting the expression of Nrf-2. Neuroreport (IF 1.7) Pub Date : 2024-01-12 Xin Hong, Qian Deng, Chunming Zhao, Yanan Zhang, Gang Wu
Research has shown that neuronal ferroptosis is associated with various central nervous system diseases, including Parkinson's disease, acute brain injury, and spinal cord injury. Inhibiting neuronal ferroptosis can greatly alleviate the progression of these diseases. However, there is currently a lack of effective drugs to inhibit neuronal ferroptosis. In this study, we pretreated neuronal cells with
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Absence of eye position effects in the early auditory cortex of monkeys. Neuroreport (IF 1.7) Pub Date : 2024-01-09 Ying Huang, Michael Brosch
This study aims to investigate whether the position of the eyes affects the neuronal activity in auditory cortex in a condition in which not the active control of eye position but the execution of hand movements was required relative to stimuli. Two monkeys were trained to perform audio-visual tasks in which they had to use their hand to respond to both the visual and the auditory stimuli to earn a
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Altered functional connectivity between the default mode network in primary angle-closure glaucoma patients. Neuroreport (IF 1.7) Pub Date : 2024-01-09 Qiu-Yu Tang, Bing-Lin Huang, Xin Huang
Previous studies have recognized glaucoma as a neurodegenerative disease that causes extensive brain damage and is closely associated with cognitive function. In this study, we employed functional MRI to examine the intrinsic functional connectivity patterns of the default mode network (DMN) in patients diagnosed with primary angle-closure glaucoma (PACG), exploring its association with cognitive dysfunction
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Exercise alters molecular rhythms in the central nervous system that negatively correlate with depression-like behavior. Neuroreport (IF 1.7) Pub Date : 2024-01-05 Lei Yu, Haonan Xue, Zhongtang Li
Major depressive disorder (MDD) ranks among the top 10 leading causes of death. However, exercise is known to improve depressive symptoms but the mechanism responsible is still unknown. To date, numerous studies have shown that molecular rhythms and exercise are associated with MDD. Thus, we hypothesized that exercise could affect the expression of central nervous system clock genes to improve depressive
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Naringenin alleviates cognitive dysfunction in rats with cerebral ischemia/reperfusion injury through up-regulating hippocampal BDNF-TrkB signaling: involving suppression in neuroinflammation and oxidative stress. Neuroreport (IF 1.7) Pub Date : 2023-12-22 Xiao-Qin Zhu, Dong Gao
Cognitive dysfunction is one of the common complications of cerebral ischemia-reperfusion (CI/R) injury after ischemic stroke. Neuroinflammation and oxidative stress are the core pathological mechanism of CI/R injury. The activation of brain derived neurotrophic factor (BDNF)-tyrosine receptor kinase B (TrkB) signaling antagonize cognitive dysfunction in a series of neuropathy. Naringenin (NAR) improves
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20(S)-Ginsenoside Rh1 alleviates sevoflurane-induced ototoxicity by reducing oxidative stress levels. Neuroreport (IF 1.7) Pub Date : 2023-12-22 Jin Lin, Li Gang, Li Wen, He Ying Zi, Shen Xia
Sevoflurane is an inhalational anesthetic widely used in pediatric surgery. However, animal studies have shown that multiple sevoflurane exposures during the neonatal period led to ototoxicity. 20(S)-Ginsenoside Rh1, a ginsenoside extract, protects against cisplatin-induced ototoxicity by scavenging free radicals.
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The influence of emotional context on emotional word processing in discourse comprehension: evidence from event-related potential. Neuroreport (IF 1.7) Pub Date : 2023-12-22 Jingwen Li, Xue Sui, Yutong Li
This research utilized event-related potential (ERP) recording technology to examine the effect of emotional context on the processing of emotional information in sentences. Three types of emotion-consistent discourse materials (neutral-neutral, positive-positive and negative-negative) were constructed to specifically express neutral, positive and negative emotions, respectively. Each discourse comprised
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Contingency learning on the proportional congruency effect of the Stroop task is manifest in deviant processing. Neuroreport (IF 1.7) Pub Date : 2023-12-22 Kota Suzuki
The proportion congruency effect has been reported in interference tasks. The mostly congruent block is the frequent condition, and the mostly incongruent block is the rare condition for congruent stimuli, whereas the mostly congruent block is the rare condition, and the mostly incongruent block is the frequent condition for incongruent stimuli. This study examined the cognitive mechanism underlying
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Sevoflurane anesthesia reduces the expression of inflammatory response genes and β-site amyloid precursor protein-cleaving enzyme in hippocampi of diabetic mice. Neuroreport (IF 1.7) Pub Date : 2023-12-19 Yu Xiang Han, Rui Liang, Xian Ping Yi, Xue Xia Zhang, Shao Peng Zhou
Diabetes and inhaled anesthesia are associated with an increased likelihood of developing postoperative cognitive dysfunction in humans and animal models, but the mechanisms are unclear. This study aimed to investigate the effect and mechanism of sevoflurane anesthesia on cognitive function in diabetic (DM) mice. Spontaneously diabetic db/db and control db/m mice were subject to sevoflurane anesthesia
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Sestrin2 attenuates depressive-like behaviors and neuroinflammation in CUMS mice through inhibiting ferroptosis. Neuroreport (IF 1.7) Pub Date : 2023-12-14 Xinxin Ma, Jing Wang, Qiankun Quan, Huan Zhang, Yuan Tian, Lei Wang, Ling Liu
Sestrin2 (SESN2) is a stress-inducible protein and acts as a neuroprotective regulator. The present study aimed to explore the antidepressant activity of SESN2 and its relevant mechanism. Depression mouse model was established by chronic unpredictable mild stress (CUMS) for a successive 5 weeks. Behaviors tests were conducted to examine depressive-like behaviors including sugar preference test, tail
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Reduction of acute radiation-induced brain injury in rats by anlotinib. Neuroreport (IF 1.7) Pub Date : 2023-12-12 Yaozu Xiong, Xilei Zhou, Changhua Yu, Yusuo Tong
Radiation therapy in the treatment of brain tumors also leads to the occurrence of radiation brain injury (RBI). Anlotinib is a small-molecule inhibitor of multi-receptor tyrosine kinase with high selectivity for vascular endothelial growth factor receptor-2. In this study, we constructed a rat model of RBI and investigated the effect of anlotinib on RBI and its mechanism of action through drug intervention
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Precise sensorimotor control impacts reproductive fitness of C. elegans in 3D environments. Neuroreport (IF 1.7) Pub Date : 2023-12-12 Hee Kyung Lee, Tong Young Lee, Jin I Lee, Kyu-Sang Park, Kyoung-Hye Yoon
The ability of animals to sense and navigate towards relevant cues in complex and elaborate habitats is paramount for their survival and reproductive success. The nematode Caenorhabditis elegans uses a simple and elegant sensorimotor program to track odors in its environments. Whether this allows the worm to effectively navigate a complex environment and increase its evolutionary success has not been
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Activation of α2A and α2B -adrenergic receptors inhibits tactile stimulation-evoked parallel fiber-Purkinje cell synaptic transmission in mouse cerebellar cortex. Neuroreport (IF 1.7) Pub Date : 2023-12-12 Jun-Ya Wang, Yue Liu, De-Lai Qiu, Chun-Ping Chu
The mechanism by which α2-adrenergic receptors (ARs) modulate the cerebellar parallel fiber-Purkinje cell (PF-PC) synaptic transmission is unclear. We investigated this issue using electrophysiological and neuropharmacological methods. Six- to eight-week-old ICR mice were used in the study. Under in vivo conditions, PF-PC synaptic transmission was evoked by facial stimulation of ipsilateral whisker
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Intravenous administration of human chorionic membrane mesenchymal stem cells promotes functional recovery in a rat traumatic brain injury model. Neuroreport (IF 1.7) Pub Date : 2023-12-12 Honglong Zhou, Zhaohui Yi, Dongsheng Le, Guohua Mao, Hongri Zhang
Human chorionic membrane mesenchymal stem cells (hCM-MSCs) have increasingly emerged as an excellent source of transplanted cells for regenerative therapy as they can be isolated via a non-invasive and simple method with high proliferative capabilities. However, the roles and mechanisms of hCM-MSCs on traumatic brain injury (TBI) animal models have not been investigated yet. The aim of this study was
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The mechanism of inhibition control in mathematical reasoning: a functional near-infrared spectroscopy study. Neuroreport (IF 1.7) Pub Date : 2023-12-12 Donglin Liu, Samrah Jamshaid, Lijuan Wang
The ability to comprehend and engage in mathematical reasoning is a fundamental cognitive skill, central to problem-solving and critical thinking. However, the intricate cognitive processes underlying mathematical reasoning, particularly in relation to inhibitory control, have garnered increasing attention in recent research. While previous studies have explored this connection, there remains a need
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Acute and sub-acute metabolic change in different brain regions induced by moderate blunt traumatic brain injury. Neuroreport (IF 1.7) Pub Date : 2023-12-04 Megha Kumari, Yasha Hasija, Richa Trivedi
The objective of the study was to observe the effect of moderate closed-head injury on hippocampal, thalamic, and striatal tissue metabolism with time. Closed head injury is responsible for metabolic changes. These changes can be permanent or temporary, depending on the injury's impact. For the experiment, 20 rats were randomly divided into four groups, each containing five animals. Animals were subjected
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Employment of time-varying sensory evidence to test the mechanisms underlying flexible decision-making. Neuroreport (IF 1.7) Pub Date : 2023-12-04 Hironori Kumano, Takanori Uka
To make flexible decisions in dynamic environments, the brain must integrate behaviorally relevant information while simultaneously discarding irrelevant information. This study aimed to investigate the mechanisms responsible for discarding irrelevant information during context-dependent decision-making. We trained two macaque monkeys to switch between direction and depth discrimination tasks in successive