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Frequent Misdiagnosis of Scabies as Eczema in China: A Descriptive Study of 23 Cases Int. J. Gen. Med. (IF 2.3) Pub Date : 2024-04-26 Xumei Wu, Feifei Yang, Ruina Zhang
Objective: To outline the clinical manifestations observed in patients with scabies misdiagnosed as generalized eczema, analyse the factors contributing to these misdiagnoses and explore potential reasons for the resurgence of scabies. Patients and Methods: A retrospective analysis was performed to investigate the patients with scabies misdiagnosed as generalized eczema. Results: We included 23 patients
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SEPT3 as a Potential Molecular Target of Triple-Negative Breast Cancer Int. J. Gen. Med. (IF 2.3) Pub Date : 2024-04-25 Li-Hua Yang, Guo-Zhou Wang, Chao Gao
Background: The survival rate for triple-negative breast cancer (TNBC) is very low due to its advanced metastatic and aggressive nature, and there is no specific target to improve the survival rate. The expression and clinical signature of neuronal-specific septin-3 (Septin3, SEPT3) in TNBC remain undetermined. Methods: SEPT3 differential expression in TNBC was detected with the use of bioinformatic
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Socio-Economic and Health Consequences of COVID-19 on Indian Migrants: A Landscape Analysis Int. J. Gen. Med. (IF 2.3) Pub Date : 2024-04-25 Poonam Trivedi, Sandul Yasobant, Deepak Saxena, Salla Atkins
Abstract: The COVID-19 pandemic has hugely affected the world and human lives, the economy, and lifestyles. The pandemic control measures, such as lockdowns, forced many people to migrate from their destination to their source in various states, leading to increased vulnerability of migrants. The present review aimed to explore the different health, economic, and social impacts on internal migrants
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Optimization of Multiplex-PCR Technique To Determine Azf Deletions in infertility Male Patients Int. J. Gen. Med. (IF 2.3) Pub Date : 2024-04-24 Tung Nguyen Thanh, Sang Trieu Tien, Phong Nguyen Van, Son Dang Thai, Thuc Luong Cong, Tuan Dinh Le, Son Tien Nguyen, Tuan Tran Van, Hoang Huy Duong, Tien Minh Bui, Kien Trung Nguyen
Background: To optimize the multiplex polymerase chain reaction (M-PCR) technique to diagnose microdeletions of azoospermia factors (AZF) on the Y chromosome and initially apply the technique to diagnose male patients with sperm density less than 5× 106 million sperm/mL was assigned to do a test to check for AZF microdeletions on the Y chromosome. Methods: Based on the positive control samples which
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Can We Predict the Grade of Clear Cell Renal Cell Carcinoma from Houns-Field Unit of Renal Lesion on Computerized Tomography Scan, a Retrospective Cross-Sectional Study Int. J. Gen. Med. (IF 2.3) Pub Date : 2024-04-23 Mohammad Al-Zubi, Khayry Al-Shami, Leen Sawalha, Heyam Mahmoud Alguzo, Saddam Al Demour, Asma’a Mohammad Al-Mnayyis, Rami Alazab, Samer Fathi Al-Rawashdah, Lana Talal Alzoubi, Sawsan Radi Al-khawaldeh
Introduction: Renal cell carcinoma (RCC) is a type of urological malignancy that affects approximately 2% of the global population. Imaging modalities, especially computed tomography (CT) scanning, play a critical role in diagnosing RCC. In this study, we investigated whether there is a relationship between tumour grade of clear cell RCC and HU values of renal lesions on CT scan performed before operation
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Clinical Value of the Diagonal Earlobe Crease in Patients with Chest Pain for Diagnosing Coronary Heart Disease Int. J. Gen. Med. (IF 2.3) Pub Date : 2024-04-23 Jie Gao, Jie Dou, Hui-Hui Yang, Ruo-Ling Guo, Chao Jiang, Gary Tse, Tong Liu, Jian-Wei Liu, Dong-Lei Luo
Purpose: To investigate the clinical application value of diagonal earlobe crease (DELC) in patients with chest pain for the diagnosis of coronary heart disease (CHD) and to construct a risk model by multivariate logistic regression. Patients and Methods: Our trial enrolled prospectively and consecutively 706 chest pain patients with suspected CHD between January 2021 to June 2023 from Chengde Central
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Modified Gwakjeongtang for Diarrhea-Predominant Irritable Bowel Syndrome: Study Protocol for a Randomized, Double-Blind, Placebo-Controlled, Pilot Clinical Trial Int. J. Gen. Med. (IF 2.3) Pub Date : 2024-04-22 Yujin Choi, Na-Yeon Ha, Ae-Ran Kim, Haein Jeong, Ojin Kwon, Ki-Sun Park, Jieun Kim, Jinsung Kim, Hyungjun Kim
Introduction: Irritable bowel syndrome (IBS) is a chronic condition characterized by recurrent abdominal pain associated with bowel movements. Modified Gwakjeongtang (MGT), an herbal prescription rooted in traditional East Asian medicine, consists of thirteen botanical drugs known for their potential to enhance intestinal barrier function, regulate gastrointestinal motility, and exhibit anti-inflammatory
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Association of Serum Uric Acid with Non-Valvular Atrial Fibrillation: A Retrospective Study in China Int. J. Gen. Med. (IF 2.3) Pub Date : 2024-04-22 Hua-Jing Yuan, Hua-Chen Jiao, Xiu-Juan Liu, Hao Hao, Yang Liu, Yi-Tao Xue, Yan Li
Purpose: The association between serum uric acid (SUA) and atrial fibrillation (AF) has been widely focused on and studied in recent years. However, the exact association between SUA and AF is unclear, and the effect of gender on the association between SUA levels and AF has been controversial. This study aimed to investigate the association between SUA levels and non-valvular AF (NVAF) and the potential
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The Therapeutic Effectiveness of Laparoscopic Sleeve Gastrectomy Among Individuals with Low BMI Obesity (30-35 Kg/m2) and the Relationship of BMI to Weight Loss Int. J. Gen. Med. (IF 2.3) Pub Date : 2024-04-23 Zilong Yue, Yan Jin, Hui Sha, Qin Wu, Lele Li, Yabin Xia, Kaifeng Hu
Purpose: Investigating the therapeutic efficacy of Laparoscopic Sleeve Gastrectomy (LSG) in low BMI (30– 35 kg/m2) patients with obesity, and exploring the correlation between patients’ preoperative BMI and postoperative weight loss. Methods: Comparing the weight loss, remission of comorbidities, occurrence of complications, and quality of life among the different BMI patients who underwent LSG. Analyzing
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Genetic Polymorphisms of Endothelial Nitric Oxide Synthase Associated with Hypertension and Blood Homocysteine Levels Int. J. Gen. Med. (IF 2.3) Pub Date : 2024-04-20 Charinya Chaichanabut, Piyamitr Sritara, Jintana Sirivarasai
Purpose: Endothelial dysfunction is a key mechanism in the development of hypertension and is closely linked to impairment of endothelial nitric oxide synthase (eNOS) and hyperhomocysteinemia. Genetic polymorphisms of eNOS (rs1799983 and rs2070744) are strongly associated with the risk of hypertension in individuals of Asian ethnicities. This study aimed to investigate the relationship between these
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Association Analysis Between Maternal Neutrophil Ratio and the Risk of Histological Chorioamnionitis in Pregnant Women with Premature Rupture of Membranes in Late Pregnancy Int. J. Gen. Med. (IF 2.3) Pub Date : 2024-04-20 Yan Lv, Zheren Huang, Yan Ma
Background: We aimed to investigate the association between maternal neutrophil ratio and histological chorioamnionitis (HCA) risk in pregnant women with premature rupture of membranes (PROM) in late pregnancy. Methods: A retrospective analysis was conducted on 95 cases of women with PROM in their late pregnancy between March 2018 and August 2021. These women were divided into two groups based on the
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Analysis of Factors Influencing Prognosis and Assessment of 60 Cases of Decompensated Cirrhotic Patients with Portal Hypertension Int. J. Gen. Med. (IF 2.3) Pub Date : 2024-04-18 Xue Fang Li, Shi Rong Liu, Jin Jin Li, Ning Liu, Hui Min Li, An Ning Ge, Liang Liang Wang, Xie Min Dong, Hui Wang, Ju Liu, Lin Zhang, Hao Dong Zhang, Wei Gou
Objective: To investigate the risk factors for the development of portal hypertension in patients with decompensated cirrhosis and analyze their prognosis. Methods: Patients with decompensated cirrhosis who were admitted to our hospital and Qu fu People’s Hospital from June 2022 to June 2023 were included in this study. Among them, there were 45 male and 15 female patients, with a median age of 56
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Progress in the Study of the Role and Mechanism of HTRA1 in Diseases Related to Vascular Abnormalities Int. J. Gen. Med. (IF 2.3) Pub Date : 2024-04-18 Shina Song, Xiaofeng Li, Xuting Xue, Wenping Dong, Changxin Li
Abstract: High temperature requirement A1 (HTRA1) is a member of the serine protease family, comprising four structural domains: IGFBP domain, Kazal domain, protease domain and PDZ domain. HTRA1 encodes a serine protease, a secreted protein that is widely expressed in the vasculature. HTRA1 regulates a wide range of physiological processes through its proteolytic activity, and is also involved in a
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The Prevalence of Hyperuricemia and the Association Between Hyperuricemia and Age in Patients with Psychiatric Disorders to a General Hospital: A Cross-Section Study Int. J. Gen. Med. (IF 2.3) Pub Date : 2024-04-17 Guodong Yang, Shuang Zhou, Yue Feng, Jiaran Lang, Yaxin Chen, Huipeng Ren
Purpose: In clinical work, it has been found that the prevalence of hyperuricemia (HUA) is significantly higher in younger patients with psychiatric disorders, but there are few studies in this area. The present study aims to evaluate the prevalence of HUA and the relationship between the HUA and age in hospitalized patients with psychiatric disorders in the real world, and to provide a theoretical
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BCL9 is a Risk Factor of Neck Lymph Nodes Metastasis and Correlated with Immune Cell Infiltration in Papillary Thyroid Carcinoma Int. J. Gen. Med. (IF 2.3) Pub Date : 2024-04-16 Rui Zhang, Zhengwei Gui, Jianguo Zhao, Lu Zhao
Purpose: B-cell lymphoma 9 (BCL9), a key transcription co-activator of the Wnt pathway, contributed to tumor progression and metastasis in various tumors, whereas, the role of BCL9 in papillary thyroid cancer (PTC) has not been investigated. Methods: We acquired PTC gene expression data from The Cancer Genome Atlas (TCGA) database. Fifty-nine PTC tissues were applied to validate the clinical significance
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Low Estradiol Level and Endometrial Thickness on the Day of Endometrial Transformation Influence Clinical Pregnancy After Intrauterine Insemination Int. J. Gen. Med. (IF 2.3) Pub Date : 2024-04-15 Qiaofei Tang, Honggan Yi, Siping Chen, Yantian Zheng, Yitao Wen, Man Yang
Background: The causes of pregnancy failure after intrauterine insemination (IUI) are controversial. The purpose of this study was to investigate the influencing factors on clinical pregnancy after IUI. Methods: This study retrospectively analyzed 1464 cycles of IUI performed at the Meizhou People’s Hospital between March 2014 and June 2023. The χ2 test and logistic regression analysis was applied
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Chemical and Microbiological Changes of Expired Platelet Concentrate Int. J. Gen. Med. (IF 2.3) Pub Date : 2024-04-10 Nora Y Hakami, Abdulrahman M Al-Ahdal, Afnan J Al-Sulami, Httan M Alabbadi, Mamdouh M Sindi, Kholoud A Gholam, Maiman M Bayuomi, Talal Qadah
Background: Platelets are a commonly used blood component to prevent or treat bleeding in patients with thrombocytopenia or platelet dysfunction. They are stored at room temperature (22– 24°C) for five days unless specific measures are taken to extend the shelf life to seven days or more. After five days, this study evaluated platelet units’ biochemical changes and bacterial growth. Study Design and
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Advances in the Study of Non-Coding RNA in the Signaling Pathway of Pulmonary Fibrosis Int. J. Gen. Med. (IF 2.3) Pub Date : 2024-04-10 Dengyun Pan, Xin Di, Bingdi Yan, Xiaomin Su
Abstract: Pulmonary fibrosis is a group of chronic, progressive, and irreversible interstitial lung diseases, which are common to most end-stage lung diseases and are one of the most difficult diseases of the respiratory system. In recent years, due to the frequent occurrence of air pollution and smog, the incidence of pulmonary fibrosis in China has increased year by year, the morbidity and mortality
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A Retrospective Study of Biological Risk Factors Associated with Primary Knee Osteoarthritis and the Development of a Nomogram Model Int. J. Gen. Med. (IF 2.3) Pub Date : 2024-04-09 Qingzhu Zhang, Yinhui Yao, Yufeng Chen, Dong Ren, Pengcheng Wang
Aim: A high percentage of the elderly suffer from knee osteoarthritis (KOA), which imposes a certain economic burden on them and on society as a whole. The purpose of this study is to examine the risk of KOA and to develop a KOA nomogram model that can timely intervene in this disease to decrease patient psychological burdens. Methods: Data was collected from patients with KOA and without KOA at our
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The Combination of circEPSTI1 and MIF Offers Diagnostic Value for Endometrial Cancer Int. J. Gen. Med. (IF 2.3) Pub Date : 2024-04-08 Zhili Cui, Liyuan Zhou, Xin An, Wenli Liu, Jingxia Li, Yueping Zhang, Wei Zhang
Background: Circular RNAs (circRNAs) exhibit unique patterns of expression and high levels of stability in patient plasma samples such that they represent ideal non-invasive biomarkers that can be leveraged to detect a wide array of diseases including endometrial cancer (EC). This study was designed to identify circRNAs with potential diagnostic utility in serum samples from EC patients while also
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Characteristics and Differences in Mpox Patients with and without HIV Infection: A Retrospective Cross-Sectional Study in Chengdu, China Int. J. Gen. Med. (IF 2.3) Pub Date : 2024-04-08 Bennan Zhao, Qingxiao Liu, Qing Du, Jun Kang, Rong Tang, Yalan Tu, Dafeng Liu
Purpose: To date, there are few reports about mpox case series in China, and scarce information is available about the in-vivo kinetics of T-cell responses in the early stage of mpox infection. This study aims to investigate the clinical difference among mpox patients with and without human immunodeficiency virus (HIV) infection. Patients and Methods: A total of 56 patients diagnosed with mpox by Chengdu
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Predictors and Clinical Significance of Myocardial Injury in Elderly Patients Under the COVID-19 Pandemic Int. J. Gen. Med. (IF 2.3) Pub Date : 2024-04-06 You Zhou, Jing Dong, Hao Lu
Background: The elderly patients are at increased high risk of myocardial injury and mortality after the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. This study aims to investigate the prevalence, predictors and prognostic implications of myocardial injury in the elderly patients with SARS-CoV-2 infection. Methods: Patients aged over 65 years were consecutively recruited
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Microbial Disruptions in Inflammatory Bowel Disease: A Comparative Analysis Int. J. Gen. Med. (IF 2.3) Pub Date : 2024-04-06 Jianxia Ma, Ke Wang, Jun Wang, Qinlian Zeng, Kangwei Liu, Songbai Zheng, Yuanwen Chen, Jianfeng Yao
Objective: The fecal microbiota was studied in patients with inflammatory bowel disease (IBD), and the characteristics of gut microbiota were compared among patients with different subtypes and stages of IBD, aiming to identify the gut microbiota associated with IBD. Methods: Fecal samples were collected from 41 IBD patients (18 patients with ulcerative colitis [UC] and 23 patients with Crohn’s disease
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The Use of Muscle Relaxants After Chemotherapy and Radiotherapy Int. J. Gen. Med. (IF 2.3) Pub Date : 2024-04-04 Paweł Radkowski, Michał Jacewicz, Iwona Podlińska, Maria Derkaczew
Introduction: Patients after chemotherapy and radiotherapy while being operated can suffer from different systemic problems, which may complicate the anesthetic management. Some interactions between muscle relaxants and chemotherapeutics can occur. Aim: This article aims to present the use of muscle relaxants in cancer patients who have undergone chemotherapy and radiotherapy. Material and Methods:
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Prevalence and Patterns of Congenital Heart Defects and Other Major Non-Syndromic Congenital Anomalies Among Down Syndrome Patients: A Retrospective Study Int. J. Gen. Med. (IF 2.3) Pub Date : 2024-04-04 Biniam Endale Geleta, Girma Seyoum
Background: Children with DS are at higher risk of developing congenital anomalies, particularly cardiac anomalies. Methods: Medical records of 502 DS patients were reviewed. The logistic regression analyses were performed to determine independent predictors. Results: Of the total 502 study subjects, 53.4% were males. Only 1.4% of the DS case diagnosis were confirmed by karyotyping. All cases were
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Formula Feeding Practice and Associated Factors Among Mothers Who Visited Health Facilities for Their Infants Aged Below 6 Months in Bahir Dar City, Northwest Ethiopia, 2020 [Letter] Int. J. Gen. Med. (IF 2.3) Pub Date : 2024-04-04 Vernando Yanry Lameky
Letter for the article Formula Feeding Practice and Associated Factors Among Mothers Who Visited Health Facilities for Their Infants Aged Below 6 Months in Bahir Dar City, Northwest Ethiopia, 2020
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Laying the Groundwork: A Pilot Study Exploring Improved Endometriosis Management Strategies in Primary Healthcare Int. J. Gen. Med. (IF 2.3) Pub Date : 2024-04-05 Maria Öberg Westin, Carl Wikberg, Cecilia Björkelund, Nashmil Ariai, Ann-Christine Lindahl, Dominique Hange
Objective: To evaluate if a brief educational intervention for primary health care staff regarding endometriosis gives sustainable knowledge of endometriosis symptoms and if a brief questionnaire for women seeking care for common symptoms is feasible in the Swedish primary care context. Design: Pilot study. Setting: 3 primary care centres (PCCs) in Sweden. Exploring knowledge among staff about endometriosis
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Correlation Between Maternal Anxiety During Mid-Pregnancy and Subsequent Infant Sleep Issues [Letter] Int. J. Gen. Med. (IF 2.3) Pub Date : 2024-04-04 Azniah Syam, Hasta Handayani Idrus, Imelda Iskandar
Letter for the article Correlation Between Maternal Anxiety During Mid-Pregnancy and Subsequent Infant Sleep Issues: A Cross-Sectional Study from 2015 to 2016
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Association Between Family History in Patients with Primary Gout and Left Ventricular Diastolic Function: A Cross-Sectional Study Int. J. Gen. Med. (IF 2.3) Pub Date : 2024-04-03 Wen Wen, Ping Lei, Wantai Dang, Liwen Ma, Jing Hu, Jian Liu
Objective: This study aimed to employ echocardiography for measuring the markers of left ventricular (LV) diastolic function to investigate the effects of family history of gout on the LV diastolic function in patients with primary gout. Methods: Two hundred and eighty-four patients with primary gout who visited the Department of Rheumatology and Immunology of the First Affiliated Hospital of Chengdu
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The Prevalence and Risk Factors of Trichosporonosis at King Abdulaziz University Hospital Int. J. Gen. Med. (IF 2.3) Pub Date : 2024-04-03 Ghassan J Alboloshi, Asif A Jiman-Fatani, Dalya Attallah, Jawahir A Mokhtar, Nabeela Abdullah Al-Abdullah, Khalil Alkuwaity, Reham Kaki, Mohammed W Al-Rabia, Abdelbagi Alfadil, Karem Ibrahem, Addisu D Teklemariam, Steve Harakeh
Background: Fungal infections, especially those caused have emerged as a significant medical concern over the past three decades, particularly among immunocompromised patients. However, recent studies have highlighted the increasing prevalence of fungal infections resembling yeast other than Candida, such as trichosporonosis, especially among immunosuppressed individuals worldwide. Trichosporon has
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Lack of Physician-Dentist Collaboration in Aspiration Pneumonia Prevention Int. J. Gen. Med. (IF 2.3) Pub Date : 2024-04-03 Taiju Miyagami, Satoshi Teranaka, Yuichiro Mine, Tomohiro Matsumoto, Yuki Yoshimatsu, Shinichi Matsumoto, Kohei Yamaguchi, Toru Morikawa
Abstract: This opinion paper addresses the challenges and future directions for preventing aspiration pneumonia in Japan’s rapidly aging population. It highlights the increasing proportion of elderly individuals and the associated rise in health issues like decreased swallowing function, a risk factor for aspiration pneumonia. The paper emphasizes the effectiveness of dentist-provided oral care in
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Awareness, Attitude, and Fertility Desire in Elective Oocyte Cryopreservation of Adults in Four Areas of China Int. J. Gen. Med. (IF 2.3) Pub Date : 2024-04-02 Yijing Xie, Chenge Liao, Xiaomei Zhai
Purpose: Controversy exists on whether or not elective oocyte cryopreservation (eOC) can be conducted in public hospitals in China. Policymakers should take into account the benefits and risks in the Chinese population. This study explored basic data concerning the awareness, attitudes of eOC, and fertility desire of eOC in China to offer evidence for policy making. Methods: A total of 442 people in
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HE4 Serum Levels are Associated with Poor Prognosis in Patients with Acute Heart Failure Combined with Chronic Kidney Disease Int. J. Gen. Med. (IF 2.3) Pub Date : 2024-04-02 Yi Tang, Zhengqi Hu, Zhibin Liu, Siling Peng, Tiancheng Liu, Yaoyuan Xiao, Jianqiang Peng, Hongwei Pan, Zhaofen Zheng, Jin He
Purpose: The levels of human epididymis protein 4 (HE4) is associated not only with the prognosis of patients with acute heart failure (AHF), but also with chronic kidney disease (CKD). Our study aims to understand the prediction value of HE4 on prognosis in patients with AHF combined with CKD. Patients and Methods: This study prospectively enrolled patients diagnosed with AHF combined with CKD at
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Diagnostic Value of Carotid Plaque Assessment with AIS Based on Quantitative Parameters of Dual-Layer Detector Spectral CT Int. J. Gen. Med. (IF 2.3) Pub Date : 2024-03-30 Xiaoying Meng, Fei Li, Wenpei Wu, Juncang Wu
Purpose: To investigate the quantitative assessment of carotid plaque by each parameter of dual-layer detector spectral CT and its diagnostic value in patients with acute cerebral infarction. Patients and Methods: Eighty-three patients with carotid atherosclerotic plaques who underwent spectral CT scanning were retrospectively included. Forty-two patients with acute ischaemic stroke (AIS) were included
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The Effects of Budesonide Inhalation Treatment on the Expression Levels of Serum IL-6, TGF-β1, and IgE and Pulmonary Function in Patients with Cough Variant Asthma and an Evaluation of Treatment Efficacy Int. J. Gen. Med. (IF 2.3) Pub Date : 2024-03-29 Yueying Niu, Mengqing Cao, Shumin Li, Juanfen Mo, Ziyi Zhu, Haiqin Wang
Objective: To retrospectively study the effects of budesonide inhalation combined with conventional symptomatic treatment on serum inflammatory factor expression levels and pulmonary function in patients with cough variant asthma (CVA) and to evaluate treatment efficacy. Methods: This retrospective cohort study included 200 patients diagnosed with CVA at the Second Hospital of Jiaxing between January
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The Potential of FOXP3 in Predicting Survival and Treatment Response in Breast Cancer Int. J. Gen. Med. (IF 2.3) Pub Date : 2024-03-28 Luyao Liu, Wang Xiao, Chaojie Zhang, Peizhi Fan, Jie Zeng, Jianing Yi
Background: Breast cancer (BC) continues to pose a substantial challenge to global health, necessitating an enhanced understanding of its fundamental mechanisms. Among its various pathological classifications, breast invasive carcinoma (BRCA) is the most prevalent. The role of the transcription factor forkhead box P3 (FOXP3), associated with regulatory T cells, in BRCA’s diagnosis and prognosis remains
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Correlations of Aflatoxin Exposure from Cooking Oil and Dietary Foods During Pregnancy with Birth Weight and Gestational Age at Birth in Guangxi, China Int. J. Gen. Med. (IF 2.3) Pub Date : 2024-03-27 Yanxu Zhong, Huan Lu, Xiaodan Lu, Zhini He, Yuyan Jiang, Jie Chen, Tippawan Liabsuetrakul
Background: Cooking oil and dietary foods are easily contaminated by aflatoxins (AFs) in Guangxi, China where low birth weight and preterm birth were prevalent. However, there are no data on AF exposure in pregnant women or their impact on newborn birth outcomes. This study aims to measure the levels and correlations of AFs in cooking oil, estimated dietary intake (EDI) of AFs in dietary foods, and
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Involvement of the ABCB1 C3435T Variant but Not the MTHFR C677T or MTHFR A1298C Variant in High-Dose Methotrexate-Induced Toxicity in Pediatric Acute Lymphoblastic Leukemia Patients in China Int. J. Gen. Med. (IF 2.3) Pub Date : 2024-03-27 Qie Guo, Jia-Lin Sun, Ran Li, Xiao Li
Purpose: It remains unclear whether the MTHFR C677T, MTHFR A1298C and ABCB1 C3435T genetic variants are associated with methotrexate (MTX) elimination delay and high-dose MTX (HD-MTX) toxicities in the treatment of pediatric acute lymphoblastic leukemia (ALL). The aim of our study was to analyze the potential predictive role of MTHFR C677T, MTHFR A1298C and ABCB1 C3435T in toxicities and the relationship
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The Association Between Epidermal Growth Factor rs3756261 A/G Gene Polymorphism and the Risk of Ankylosing Spondylitis in a Chinese Han Population Int. J. Gen. Med. (IF 2.3) Pub Date : 2024-03-27 Hui Zhang, Wei Jiang
Background: Epidermal growth factor (EGF) is a potent pro-angiogenic molecule promoting the angiogenic phenotype of ankylosing spondylitis (AS). Studies demonstrated that EGF rs3756261 polymorphism was associated with the risk of inflammatory diseases, but not including AS. Methods: To investigate the association between EGF rs3756261 polymorphism and the risk of AS, we genotyped the EGF rs3756261
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Prognostic Risk Models Using Epithelial Cells Identify β-Sitosterol as a Potential Therapeutic Target Against Esophageal Squamous Cell Carcinoma Int. J. Gen. Med. (IF 2.3) Pub Date : 2024-03-27 Zhenhu Zhang, Bin Shang, Xinyu Mao, Yamin Shi, Guodong Zhang, Dong Wang
Background: Esophageal squamous cell carcinoma (ESCC) is an aggressive and fatal malignancy that leads to epithelial cancer. The association between epithelial cell heterogeneity, prognosis, and immune response in this cancer remains uncertain. This study aimed to investigate epithelial cell heterogeneity in ESCC and develop a predictive risk model using the identified cell types. Methods: Single-cell
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Associations Between ABO Blood Groups and Diseases in the Digestive System and Vein Int. J. Gen. Med. (IF 2.3) Pub Date : 2024-03-27 Feiyu Jiang, Zhiwei Liu, Ying Zhang, Tiejun Song
Purpose: The ABO blood type system is crucial for human blood transfusions. However, the relationships between ABO blood groups and diseases in the digestive system and vein have not been elucidated. We investigated the relationships between ABO blood groups and diseases in the digestive system and vein in this study. Patients and Methods: A retrospective study on a Chinese population, including 1432
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Patients and Health Professionals’ Perceptions of Primary Health Care Services in Saudi Arabia: A Scoping Review Int. J. Gen. Med. (IF 2.3) Pub Date : 2024-03-26 Abeer Alharbi, Mohammed Aljuaid
Objective: This scoping review aims to identify and summarize existing evidence concerning the quality and capacity of PHC services in the Kingdom of Saudi Arabia (KSA) with a focus on the patients and healthcare professionals’ perceptions of PHC. Methods: This review followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The digital library, PubMed, and
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Gastrointestinal Bleeding in COVID-19 Infected Patients, and Management Outcomes Int. J. Gen. Med. (IF 2.3) Pub Date : 2024-03-27 Amnah Al Hanaei, Fatima AlKindi, Aysha Alkhemeiri, Satish Chandrasekhar Nair
Introduction: Gastrointestinal bleeding in COVID-19-infection poses unique challenges to patients owing to the high risk of concomitant respiratory failure. However, endoscopic care providers are prone to transmission. This study aimed to understand the risk and management outcomes of gastrointestinal bleeding in COVID-19-infected patients. Methods: Data were abstracted from electronic patient medical
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The Administration of Lemborexant at Admission is Not Associated with Inpatient Falls: A Multicenter Retrospective Observational Study Int. J. Gen. Med. (IF 2.3) Pub Date : 2024-03-25 Risa Hirata, Naoko E Katsuki, Hitomi Shimada, Eiji Nakatani, Kiyoshi Shikino, Chihiro Saito, Kaori Amari, Yoshimasa Oda, Midori Tokushima, Masaki Tago
Purpose: There has been no large-scale investigation into the association between the use of lemborexant, suvorexant, and ramelteon and falls in a large population. This study, serving as a pilot investigation, was aimed at examining the relationship between inpatient falls and various prescribed hypnotic medications at admission. Patients and Methods: This study was a sub-analysis of a multicenter
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Impact of Platelet Hyperreactivity and Diabetes Mellitus on Ischemic Stroke Recurrence: A Single-Center Cohort Clinical Study Int. J. Gen. Med. (IF 2.3) Pub Date : 2024-03-23 Yusheng Mao, Bangqiang Zhu, Huiqin Wen, Tao Zhong, Maohong Bian
Purpose: Ischemic stroke recurrence (ISR) is prevented by inhibiting platelet function. To investigate the impact of high on-treatment platelet reactivity (HTPR) assessed by thromboelastography (TEG) and its risk factors on ISR in individuals who have experienced acute ischemic stroke (AIS) receiving dual anti-platelet therapy (DAPT). Patients and Methods: At the end of follow-up, a total of 264 patients
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Predicting Endothelium-Dependent Diastolic Function (FMD) and Its Correlation with the Degree of Coronary Artery Disease (CAD) and Plaque Vulnerability for Cardiovascular Events Int. J. Gen. Med. (IF 2.3) Pub Date : 2024-03-22 Guangming Zhang, Jing Yang, Hanghang Xing, Hongning Yin, Guoqing Gu
Objective: This study aims to investigate the correlation between vascular endothelium-dependent diastolic function (FMD) and the degree of coronary artery disease (CAD), plaque vulnerability, and its predictive value for cardiovascular events. Methods: Initially, patients (n=100) who were admitted from January 2020 to January 2021 and intended to undergo percutaneous coronary intervention (PCI) were
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Health Hazard Among Shrimp Cultivators in India: A Quantitative Burden of Disease Study Int. J. Gen. Med. (IF 2.3) Pub Date : 2024-03-21 Chandan Kumar Swain, Himanshu Sekhar Rout, Mihajlo Jakovljevic
Background: The lack of focus on the health status of shrimp cultivators by previous studies while the production of shrimp has been rising over the years after the introduction of the blue revolution in India. The present study estimated the burden of diseases among shrimp cultivators in India. Methods: Primary data were collected by using simple random sampling. The sample size was 357. The classification
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Mapping the Spatial Evolution of Proximal Femur Osteoporosis: A Retrospective Cross-Sectional Study Based on CT Scans Int. J. Gen. Med. (IF 2.3) Pub Date : 2024-03-21 Robert B Bot, Razvan Chirla, Calin Tudor Hozan, Simona Cavalu
Purpose: The purpose of this study was to quantify the modifications occurring in osteoporosis at the level of the human proximal femur throughout the trabecular structure, along with the identification of certain anatomic regions preferentially affected by osteoporosis. Another goal was to map the evolution of the radiodensity of the trabecular bone as osteoporosis progresses to an advanced stage
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Clinical Presentation and 6-Month Outcomes of Patients with Peripartum Cardiomyopathy in Indonesia Int. J. Gen. Med. (IF 2.3) Pub Date : 2024-03-21 Hawani Sasmaya Prameswari, Triwedya Indra Dewi, Melawati Hasan, Erwan Martanto, Astri Astuti, Aninka Saboe, Charlotte Johanna Cool
Background: Due to the rarity of peripartum cardiomyopathy (PPCM) globally, baseline characteristic data for PPCM patients are still scarce. Therefore, this study aims to determine the baseline characteristics and 6-month outcomes of PPCM patients in Indonesia. Methods: From January 2014 to December 2021, all PPCM patients aged ≥ 18 years who were admitted to Dr. Hasan Sadikin General Hospital in Bandung
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Downregulation of INPP4B is Associated with Poor Prognosis in Epithelial Ovarian Carcinoma Int. J. Gen. Med. (IF 2.3) Pub Date : 2024-03-20 Liangliang Jiang, Jing Wang
Background: INPP4B is a tyrosine-specific phosphatase in the human body, which plays an important role in the developing process of carcinogenesis. However, The correlation between INPP4B and epithelial ovarian cancer is rarely explored. In this study, the expression of INPP4B in human epithelial ovarian carcinoma and normal ovaries was detected, to explore the correlation between INPP4B expression
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Awareness, Knowledge, Attitude, and Skills (AKAS) of Telemedicine and Its Use by Primary Healthcare Providers Int. J. Gen. Med. (IF 2.3) Pub Date : 2024-03-19 Najla A Barnawi, Hazza Al-Otaibi, Abdulaziz I Alkhudairy, Mohammed A Alajlan, Renad A Alajlan, Saeed M Alay, Saad Mohammed Alqahtani, Ibraheem A Bushnak, Mostafa A Abolfotouh
Background: This study aimed to determine the rate of telemedicine (TM) use and the levels of awareness, knowledge, attitude, and skills of TM among primary healthcare (PHC) providers. Methods: In a cross-sectional study, 104 PHC providers were subjected to a validated AKAS scale via Survey Monkey. The tool consists of 4 parameters that users can respond to using a 4-point Likert scale to assess their
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Recurrence Rate and Influencing Factors of Helicobacter Pylori Infection After Successful Eradication in Southern Coastal China Int. J. Gen. Med. (IF 2.3) Pub Date : 2024-03-19 Daya Zhang, Fen-jiao Mao, Shimei Huang, Chen Chen, Da Li, Fan Zeng, Feihu Bai
Purpose: Recurrence rate of Helicobacter pylori (H. pylori) infection after successful eradication have gained attention. This study was to assess the recurrence rate of H. pylori infection after successful eradication in the southern coastal provinces of China and to analyze its factors. Patients and Methods: 975 patients with upper gastrointestinal symptoms who were diagnosed with H. pylori infection
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Value of Absolute Eosinophil Count in Patients with Acute Coronary Syndrome Undergoing Percutaneous Coronary Intervention Int. J. Gen. Med. (IF 2.3) Pub Date : 2024-03-18 Yufei Wang, Xiaoteng Ma, Zhiqiang Yang, Qiuxuan Li, Yujie Zhou, Fei Gao, Zhijian Wang
Background and Aims: Elevated eosinophils typically indicate hypersensitive inflammation; however, their involvement in cardiovascular events remains incompletely understood. We investigated the association between the absolute eosinophil count (AEC) and major adverse cardiovascular and cerebrovascular events (MACCEs) in patients with acute coronary syndrome (ACS) undergoing percutaneous coronary intervention
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Biomarkers in the Severity of Necrotizing Enterocolitis in Preterm Infants: A Pilot Study Int. J. Gen. Med. (IF 2.3) Pub Date : 2024-03-15 Wei Meng, Qing Wang, Qingyu Xu, Hongli Gao, Yunjun Zhou, Wei Shao
Background: The occurrence of necrotizing enterocolitis (NEC) is a common and severe disease of the digestive system in neonates. This study aims to assess the value of the intestinal tissue oxygen saturation (rintSO2) combined with the levels of procalcitonin (PCT) and mean platelet volume (MPV) in predicting the severity of NEC in preterm infants. Methods: This experiment was a retrospective cohort
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Pulmonary Manifestations of Systemic Lupus Erythematosus Among Adults in Aseer Region, Saudi Arabia Int. J. Gen. Med. (IF 2.3) Pub Date : 2024-03-15 Nouf A Alhammadi, Hanan Saeed Alqahtani, Syed Esam Mahmood, Abdulrahman Arif Alshahrani, Abdullaziz Motlaq A Alahmari, Abdullah Rashid Safer Alshahrani, Abdullah Saeed A Badawi, Ali Mohammed Ali Alqahtani, Abdullah Thabet A Alsalem, Mohammed Saeed M Alsultan Alqahtani, Mohammed Ali Gazzan
Background: Nearly half of the Systemic lupus erythematosus (SLE) patients develop lung involvement. The study assessed the extent of pulmonary involvement among SLE patients and to identify the associated factors in the population. Methodology: This retrospective cohort study was conducted at Aseer Hospital and Khamis Myshat Hospital in the Southern region of Saudi Arabia. The study spanned from January
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Prognostic Value of CRP–Albumin–Lymphocyte (CALLY) Index in Patients Undergoing Surgery for Breast Cancer Int. J. Gen. Med. (IF 2.3) Pub Date : 2024-03-15 Jiaru Zhuang, Shan Wang, Yuan Wang, Yibo Wu, Renjing Hu
Purpose: According to the 2023 global cancer data, breast cancer is the most common malignant tumor among women in the world. Its occurrence and development is influenced by inflammation, nutrition, and immune status. Therefore, this study combines C-reactive protein (CRP), albumin, and lymphocyte, which can reflect the above states, to form the CRP-albumin-lymphocyte (CALLY) index, an indicator to
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Correlation of Peripheral Blood Inflammatory Indicators to Prognosis After Intravenous Thrombolysis in Acute Ischemic Stroke: A Retrospective Study Int. J. Gen. Med. (IF 2.3) Pub Date : 2024-03-15 Tianrui Zhang, Sha Fu, Xiaofeng Cao, Yangjingyi Xia, Manyan Hu, Qinghua Feng, Yujun Cong, Yuan Zhu, Xiaogang Tang, Minghua Wu
Purpose: According to many previous studies, neutrophil-to-lymphocyte ratio (NLR), lymphocyte-to-monocyte ratio (LMR) and hypersensitive C-reactive protein (CRP) are commonly used as important indicators to assess the prognosis of intravenous thrombolysis in AIS patients. Based on this, we used two novel biomarkers C-NLR (CRP/neutrophil-to-lymphocyte ratio) and C-LMR (CRP×lymphocyte-to-monocyte ratio)
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Research Status and Trends of Traditional Chinese Medicine Therapeutic Formulae for Coronary Heart Disease Scientometrics Research Int. J. Gen. Med. (IF 2.3) Pub Date : 2024-03-12 Mi Zhou, Jieyun Li, Xinang Xiao, Jiekee Lim, Zhikui Tian, Dongjun Wang, Naijin Zhang, Zhaoxia Xu
Aim of the Study: This study analyzes research on TCM formulae in CHD over the past 30 years, using VOSviewer and CiteSpace. It aims to highlight key trends and hotspots in the field. Materials and Methods: The core database of Web of Science was collected, and the search time range was from the establishment of the database to the present (August 2023) for the literature related to the study of TCM
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Impact of AI-Powered Solutions in Rehabilitation Process: Recent Improvements and Future Trends Int. J. Gen. Med. (IF 2.3) Pub Date : 2024-03-12 Umamah bint Khalid, Muddasar Naeem, Fabrizio Stasolla, Madiha Haider Syed, Musarat Abbas, Antonio Coronato
Abstract: Rehabilitation is an important and necessary part of local and global healthcare services along with treatment and palliative care, prevention of disease, and promotion of good health. The rehabilitation process helps older and young adults even children to become as independent as possible in activities of daily life and enables participation in useful living activities, recreation, work
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The Clinical Value of Systemic Immune Inflammation Index (SII) in Predicting the Severity of Hospitalized Children with Mycoplasma Pneumoniae Pneumonia: A Retrospective Study Int. J. Gen. Med. (IF 2.3) Pub Date : 2024-03-12 Shuye Wang, Yu Wan, Wenbo Zhang
Objective: The Systemic Immune Inflammation Index (SII), as a novel inflammation biomarker that comprehensively reflects the inflammatory and immune status of the body, has not been reported in studies on Mycoplasma pneumoniae pneumonia (MPP) in children. This study aims to investigate whether SII can serve as an effective indicator for evaluating the condition of MPP. Methods: This study recruited