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Assessment of the measurement properties of the Peabody Developmental Motor Scales-2 by applying the COSMIN methodology Ital. J. Pediatr. (IF 3.6) Pub Date : 2024-04-24 Yuanye Zhu, Jiahui Hu, Weibing Ye, Mallikarjuna Korivi, Yongdong Qian
The Peabody Developmental Motor Scales-2 (PDMS-2) has been used to assess the gross and fine motor skills of children (0–6 years); however, the measurement properties of the PDMS-2 are inconclusive. Here, we aimed to systematically review the measurement properties of PDMS-2, and synthesize the quality of evidence using the Consensus-based Standards for the Selection of Health Measurements Instruments
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Pediatric torticollis: clinical report and predictors of urgency of 1409 cases Ital. J. Pediatr. (IF 3.6) Pub Date : 2024-04-24 Umberto Raucci, Marco Roversi, Alessandro Ferretti, Valerio Faccia, Giacomo Garone, Fabio Panetta, Carlo Mariani, Eloisa Rizzotto, Antonio Torelli, Giovanna Stefania Colafati, Angelo Gabriele Aulisa, Pasquale Parisi, Alberto Villani
To date, the etiology and risk factors of torticollis are still poorly defined in the pediatric literature. Especially in the Emergency Department (ED) scenario, it is critical to reliably distinguish benign and transient conditions from (potentially) life-threatening disorders. This study describes the clinical characteristics of a large sample of children with torticollis. The aim of our study was
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Comparison of different genetic testing modalities applied in paediatric patients with steroid-resistant nephrotic syndrome Ital. J. Pediatr. (IF 3.6) Pub Date : 2024-04-23 Xueting Cheng, Jiahuan Chen, Xueying Yang, Han Chan, Xia Yang, Jia Jiao, Anshuo Wang, Gaofu Zhang, Xuelan Chen, Xiaoqin Li, Mo Wang, Baohui Yang, Haiping Yang, Qiu Li
Steroid-resistant nephrotic syndrome (SRNS) are monogenic in some cases, however, there are still no clear guidelines on genetic testing in the clinical practice of SRNS in children. Three hundred thirty-two children were diagnosed with SRNS, and all children underwent genetic testing, including gene panels and/or whole-exome/genome sequencing (WES/WGS), during treatment. We analysed the relationship
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Changing clinical characteristics of pediatric inpatients with pneumonia during COVID-19 pandamic: a retrospective study Ital. J. Pediatr. (IF 3.6) Pub Date : 2024-04-23 Mengxue Chen, Yabing Zhou, Shengjie Jin, Shasha Bai, Xiaoyu Tang, Quanhua Liu, Liwei Wang, Ruoxu Ji, Haipei Liu, Wenwei Zhong, Yi Chen, Dingzhu Fang, Jianhua Zhang, Li Hua
The COVID-19 pandemic have impacts on the prevalence of other pathogens and people’s social lifestyle. This study aimed to compare the pathogen, allergen and micronutrient characteristics of pediatric inpatients with pneumonia prior to and during the COVID-19 pandemic in a large tertiary hospital in Shanghai, China. Patients with pneumonia admitted to the Department of Pediatric Pulmonology of Xinhua
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Growth impairment in children with atrophic autoimmune thyroiditis and pituitary hyperplasia Ital. J. Pediatr. (IF 3.6) Pub Date : 2024-04-23 Domenico Corica, Tiziana Abbate, Anna Malgorzata Kucharska, Malgorzata Wojcik, Francesco Vierucci, Mariella Valenzise, Alessandra Li Pomi, Giorgia Pepe, Gerdi Tuli, Beata Pyrzak, Tommaso Aversa, Malgorzata Wasniewska
Atrophic autoimmune thyroiditis (AAT) is a rare phenotype of autoimmune thyroiditis (AT) in pediatric age. AAT occurs without thyroid enlargement leading to a delay in its diagnosis. Growth impairment is infrequent in autoimmune thyroiditis, if timely diagnosed. Prolonged severe hypothyroidism is a rare cause of pituitary hyperplasia (PH) in childhood. Loss of thyroxine negative feedback causes a TRH-dependent
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Point-of-care ultrasound (POCUS) pediatric resident training course: a cross-sectional survey Ital. J. Pediatr. (IF 3.6) Pub Date : 2024-04-23 Manuela Lo Bianco, Santiago Presti, Maria Carla Finocchiaro, Gian Luca Trobia, Tiziana Virginia Sciacca, Maria Elena Cucuzza, Elia Caudullo, Giacomo Calcara, Martino Ruggieri, Vita Antonella Di Stefano
Point-of-care ultrasound (POCUS) is becoming increasingly crucial in the Pediatric Emergency Department for objective patient examination. However, despite its growing interest and wide-ranging applications, POCUS remains relatively unexplored in general pediatric training and education. Many physicians still find it challenging to comprehend and implement. A theoretical-practical POCUS course for
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Mutations in the NUP93, NUP107 and NUP160 genes cause steroid-resistant nephrotic syndrome in Chinese children Ital. J. Pediatr. (IF 3.6) Pub Date : 2024-04-22 Yanxinli Han, Hongyu Sha, Yuan Yang, Zhuowei Yu, Lanqi Zhou, Yi Wang, Fengjie Yang, Liru Qiu, Yu Zhang, Jianhua Zhou
The variants of nucleoporins are extremely rare in hereditary steroid-resistant nephrotic syndrome (SRNS). Most of the patients carrying such variants progress to end stage kidney disease (ESKD) in their childhood. More clinical and genetic data from these patients are needed to characterize their genotype–phenotype relationships and elucidate the role of nucleoporins in SRNS. Four patients of SRNS
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Two cases of diquat poisoning in adolescent children Ital. J. Pediatr. (IF 3.6) Pub Date : 2024-04-22 Mengtao Duan, Baowang Yang, Xiaohang Cheng, Fuhui Shen, Xia Lu, Fan Wang
Diquat (DQ) is among the most widely used herbicides, and its intake can cause severe systemic toxicity that manifests rapidly. The resultant symptoms can cause the dysfunction of a range of tissues and organs,. As there is no specific antidote for diquat poisoning and the efficacy of extant treatments is suboptimal, physicians must acquire a more comprehensive understanding of the most effective approaches
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Kidney and urogenital abnormalities in Down syndrome: a meta-analysis Ital. J. Pediatr. (IF 3.6) Pub Date : 2024-04-20 Caterina Maria Rossetti, Giacomo D. Simonetti, Mario G. Bianchetti, Sebastiano A. G. Lava, Giorgio Treglia, Carlo Agostoni, Gregorio P. Milani, J. Peter de Winter
Reviews on Down syndrome do not or only marginally address the issue of kidney and urogenital tract abnormalities, and lower urinary tract dysfunctions. Hence, we performed a meta-analysis of the literature. A literature search was undertaken in the Library of Medicine, Web of Science and Excerpta Medica. The search algorithm combined various keywords: (Down syndrome OR trisomy 21 OR mongolism) AND
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Severe cellulitis from methicillin-resistant Staphylococcus aureus (MRSA) in a couple of preterm twins: a case report Ital. J. Pediatr. (IF 3.6) Pub Date : 2024-04-19 Noemi Zampatti, Irene Bonato, Andrea Calandrino, Carolina Saffioti, Alessandro Parodi, Giorgia Brigati, Diego Minghetti, Luca Antonio Ramenghi
Preterms are at risk of systemic infections as the barrier function of their immature skin is insufficient. The long period of hospitalization and the huge number of invasive procedures represent a risk factor for complications. Among the nosocomial infections of the skin, methicillin-resistant Staphylococcus aureus (MRSA) is associated with significant morbidity and mortality. We report a clinical
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A simulation training of family management for parents of children with epilepsy: a randomized clinical trial Ital. J. Pediatr. (IF 3.6) Pub Date : 2024-04-19 Hua-yan Liu, Shan Zeng, Yue-wei Chen, Min Yi, Xiao-yan Tan, Jian-hui Xie, Xia Wu, Li-hui Zhu
Epilepsy is a chronic neurological disorder that is more likely to be diagnosed in children. The main treatment involves long-term use of anti-epileptic drugs and above all, home care is of great importance. As there has not been a widely accepted home care protocols, simulating a home care environment is necessary for caregivers to develop skills of proper home care. This study aims to evaluate the
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“Quality of Life in Epidermolysis Bullosa” and “Epidermolysis Bullosa Burden of Disease”: Italian translation, cultural adaptation, and pilot testing of two disease-specific questionnaires Ital. J. Pediatr. (IF 3.6) Pub Date : 2024-04-19 May El Hachem, Andrea Diociaiuti, Giovanna Zambruno, Tonia Samela, Francesca Ferretti, Claudia Carnevale, Renata Linertová, Christine Bodemer, Dédée F. Murrell, Damiano Abeni
Inherited epidermolysis bullosa (EB) is a clinically and genetically heterogeneous group of skin fragility disorders characterized by blister formation following minor trauma. Four major types are distinguished based on the level of cleavage within the skin. Most EB forms present severely disabling cutaneous and systemic signs and symptoms. Management relies on daily time-consuming and distressing
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Tri-ponderal mass index and left ventricular hypertrophy in a cohort of caucasian children and adolescents with obesity Ital. J. Pediatr. (IF 3.6) Pub Date : 2024-04-19 Sara Vizzuso, Alberico Del Torto, Giulia Fiore, Stefano Carugo, Gianvincenzo Zuccotti, Elvira Verduci
Pediatric obesity is a global emerging burden for society; among its health-related consequences there are hypertension (HTN) and left ventricular hypertrophy (LVH). Several anthropometric indices have been investigated for the early identification of cardiovascular risk in children. The aim of the present study was to assess whether tri-ponderal mass index (TMI) was associated with LVH in a cohort
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Clinical features of plastic bronchitis in children after congenital heart surgery Ital. J. Pediatr. (IF 3.6) Pub Date : 2024-04-19 Li-Min Zhu, Chun-Xiang Li, Xiao-Lei Gong, Zhuo-Ming Xu, Jin-Long Liu, Hai-Bo Zhang
Plastic bronchitis (PB) can occur in patients who have undergone congenital heart surgery (CHS). This study aimed to investigate the clinical features of PB in children after CHS. We conducted a retrospective cohort study using the electronic medical record system. The study population consisted of children diagnosed with PB after bronchoscopy in the cardiac intensive care unit after CHS from May 2016
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Adolescent gender dysphoria management: position paper from the Italian Academy of Pediatrics, the Italian Society of Pediatrics, the Italian Society for Pediatric Endocrinology and Diabetes, the Italian Society of Adolescent Medicine and the Italian Society of Child and Adolescent Neuropsychiatry Ital. J. Pediatr. (IF 3.6) Pub Date : 2024-04-18 Valeria Calcaterra, Gianluca Tornese, Gianvincenzo Zuccotti, Annamaria Staiano, Valentino Cherubini, Rossella Gaudino, Elisa Maria Fazzi, Egidio Barbi, Francesco Chiarelli, Giovanni Corsello, Susanna Maria Roberta Esposito, Pietro Ferrara, Lorenzo Iughetti, Nicola Laforgia, Mohamad Maghnie, Gianluigi Marseglia, Giorgio Perilongo, Massimo Pettoello-Mantovani, Martino Ruggieri, Giovanna Russo, Mariacarolina
In response to the imperative need for standardized support for adolescent Gender Dysphoria (GD), the Italian Academy of Pediatrics, in collaboration with the Italian Society of Pediatrics, the Italian Society for Pediatric Endocrinology and Diabetes, Italian Society of Adolescent Medicine and Italian Society of Child and Adolescent Neuropsychiatry is drafting a position paper. The purpose of this
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Prevalence of autoimmune thyroiditis among children with autoimmune hepatitis Ital. J. Pediatr. (IF 3.6) Pub Date : 2024-04-18 Engy Adel Mogahed, Hend M. Soliman, Dalia Saber Morgan, Hoda Mohammed Abd Elaal, Rasha Abd El Razek Mahmoud Khattab, Ragaey A. Eid, Mahmoud Hodeib
Autoimmune hepatitis (AIH) is an organ specific autoimmune disease, which can manifest at any age of life. there is a high prevalence of extrahepatic autoimmune diseases in patients with AIH. Autoimmune thyroid diseases (ATDs) are the most frequent extrahepatic autoimmune disorders among patients with AIH. Aim of work is to detect the frequency of ATDs among Egyptian children with AIH. This research
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Unusual cerebral intraventricular hemorrhage and cardiomyopathy related to congenital cytomegalovirus from non-primary maternal infection: a case report Ital. J. Pediatr. (IF 3.6) Pub Date : 2024-04-16 Victoria Malherbe, Stefanie Celen, Katherine Carkeek, Evelina Carapancea, Cinzia Auriti, Fiammetta Piersigilli
Congenital cytomegalovirus (cCMV) infection, resulting from non-primary maternal infection or reactivation during pregnancy, can cause serious fetal abnormalities, complications in the immediate neonatal period, and severe sequelae later in childhood. Maternal non-primary cytomegalovirus infection in pregnancy is transmitted to the fetus in 0.5-2% of cases (1). An African full term male newbornwas
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Acute compartment syndrome and fasciotomy after a viper bite in Italy: a case report Ital. J. Pediatr. (IF 3.6) Pub Date : 2024-04-16 Marco Sassoè-Pognetto, Riccardo Cavalcante, Matteo Paonessa
Bites caused by European vipers are rare medical emergencies but can occasionally cause life-threatening complications. Viper venom causes local symptoms, which can be accompanied by systemic manifestations in severe cases. The local effects of snakebites include edema and, more rarely, necrosis and compartment syndrome. The consequences of envenomation are often more pronounced in children due to
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The impact of indoor air pollution on children’s health and well-being: the experts’ consensus Ital. J. Pediatr. (IF 3.6) Pub Date : 2024-04-14 Elena Bozzola, Rino Agostiniani, Laura Pacifici Noja, Jibin Park, Paolo Lauriola, Tiziana Nicoletti, Domenica Taruscio, Giovanni Taruscio, Alberto Mantovani
Pollution of the indoor environment represents a concern for human health, mainly in case of prolonged exposure such as in the case of women, children, the elderly, and the chronically ill, who spend most of their time in closed environments. The aim of the study is to organize a group of experts in order to evaluate the evidence and discuss the main risk factors concerning indoor air and the impact
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Evaluation of apparently healthy Egyptian infants and toddlers on the bayley-III scales according to age and sex Ital. J. Pediatr. (IF 3.6) Pub Date : 2024-04-14 Zeinab M. Monir, Ebtissam M. Salah El-Din, Wafaa A. Kandeel, Sara F. Sallam, Eman Elsheikh, Mones M. Abushady, Fawzia Hasseb Allah, Sawsan Tawfik, Dina Abu Zeid
Child development is shaped throughout the first years of life through the interaction of genetics and the environment. Bayley-III is valuably used to determine early developmental delay (DD). The aim of this study was to detect the differences in performance of a sample of apparently healthy Egyptian infants and toddlers on the Bayley-III scales in relation to their age and gender. This was a cross-sectional
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Carnitine palmitoyltransferase II (CPT II) deficiency responsible for refractory cardiac arrhythmias, acute multiorgan failure and early fatal outcome Ital. J. Pediatr. (IF 3.6) Pub Date : 2024-04-14 Gregorio Serra, Vincenzo Antona, Vincenzo Insinga, Giusy Morgante, Alessia Vassallo, Simona La Placa, Ettore Piro, Sergio Salerno, Ingrid Anne Mandy Schierz, Eloisa Gitto, Mario Giuffrè, Giovanni Corsello
Carnitine palmitoyltransferase II (CPT II) deficiency is a rare inborn error of mitochondrial fatty acid metabolism with autosomal recessive pattern of inheritance. Its phenotype is highly variable (neonatal, infantile, and adult onset) on the base of mutations of the CPT II gene. In affected subjects, long-chain acylcarnitines cannot be subdivided into carnitine and acyl-CoA, leading to their toxic
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Clinical-functional correlation with brain volumetry in severe perinatal asphyxia: a case report Ital. J. Pediatr. (IF 3.6) Pub Date : 2024-04-09 Juan Pablo Velasquez-Minoli, Natalia Cardona-Ramirez, Hernan Felipe Garcia-Arias, Feliza Restrepo-Restrepo, Gloria Liliana Porras-Hurtado
Hypoxic-ischemic encephalopathy (HIE) appears in neurological conditions where some brain areas are likely to be injured, such as deep grey matter, basal ganglia area, and white matter subcortical periventricular áreas. Moreover, modeling these brain areas in a newborn is challenging due to significant variability in the intensities associated with HIE conditions. This paper aims to evaluate functional
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Epidemiology of respiratory syncytial virus in a large pediatric hospital in Central Italy and development of a forecasting model to predict the seasonal peak Ital. J. Pediatr. (IF 3.6) Pub Date : 2024-04-08 Renato Cutrera, Marta Luisa Ciofi degli Atti, Andrea Dotta, Carmen D’Amore, Lucilla Ravà, Carlo Federico Perno, Alberto Villani
Respiratory Syncytial Virus (RSV) is responsible for the majority of acute lower respiratory infections in infants and can affect also older age groups. Restrictions linked to the emergence of the SARS-CoV-2 pandemic and their subsequent lifting caused a change in the dynamics of RSV circulation. It is therefore fundamental to monitor RSV seasonal trends and to be able to predict its seasonal peak
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Association of congenital heart disease and neurodevelopmental disorders: an observational and Mendelian randomization study Ital. J. Pediatr. (IF 3.6) Pub Date : 2024-04-08 Zhi-yuan Liu, Qiong-qiong Wang, Xian-yong Pang, Xiao-bi Huang, Gui-ming Yang, Sheng Zhao
This study aims to thoroughly study the connection between congenital heart disease (CHD) and neurodevelopmental disorders (NDDs) through observational and Mendelian randomization (MR) designs. This observational study uses data from the National Survey of Children’s Health (2020–2021). Multivariable logistic regression and propensity score matching (PSM) were performed to analyze the association.
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Association study of FLT4 and HYDIN single nucleotide polymorphisms with atrial septal defect susceptibility in the Han Chinese population of Southwest China Ital. J. Pediatr. (IF 3.6) Pub Date : 2024-04-05 Ye Jin, Miao Zhao, Qiuzhe Guo, Wanyu Zhao, Min Lei, Yifei Zhang, Yunhan zhang, Yan Shen, Keqin Lin, Zhaoqing Yang, Jiayou Chu, Hao Sun, Zhiling Luo
Atrial septal defect (ASD) is a common form of congenital heart disease. Although several genes related to ASD have been found, the genetic factors of ASD remain unclear. This study aimed to evaluate the correlation between 10 candidate single nucleotide polymorphisms (SNPs) and sporadic atrial septal defects. Based on the results of 34 individual whole exome sequences, 10 candidate SNPs were selected
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The myofascial release as neuromotor support to improve the ineffective sucking ability in term infants: a preliminary study Ital. J. Pediatr. (IF 3.6) Pub Date : 2024-04-05 Andrea Arcusio, Maria Cristina Villa, Federica Felloni, Claudio Migliori
Breastfeeding plays a primary role in the events that characterize the development of the relationship between a mother and her newborn. However, this essential process sometimes does not fully cover the nutritional requirements of the newborn due to altered biomechanical sucking skills. In this context, adequate osteopathic treatment associated with neuromotor facilitation techniques could play a
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ESDM intervention in severe preschool autism: an Italian Case report, psychological and social medicine reflections Ital. J. Pediatr. (IF 3.6) Pub Date : 2024-04-04 Rosaria Ferrara, Felice Damato, Leonardo Iovino, Flavio Marti, Roberto Latina, Costanza Colombi, Pasquale Ricci
The goal of our contribution is to discuss a preschool intervention based on the Early Start Denver Model and the use of the main tools for the detection of adaptive behaviour in cases of autism: Vineland, ABAS. Case presentation: the work is the presentation of a clinical case that has benefited from an intervention with the Early Start Denver Model methodology for the benefit of a child with socio-cultural
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The ten “hard” questions in pediatric functional constipation Ital. J. Pediatr. (IF 3.6) Pub Date : 2024-04-08 Flora Fedele, Maria Teresa Fioretti, Elena Scarpato, Massimo Martinelli, Caterina Strisciuglio, Erasmo Miele
Functional constipation is a common problem in childhood and has a great impact on social, physical, and emotional functioning of affected children and their caregivers. No organic cause of the constipation can be found in approximately 95% of children, defining the “so-called” chronic functional constipation. Its prevalence has been reported to range from 0.7 to 29.6%, with a median of 12%. The diagnosis
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New and old criteria for diagnosing celiac disease: do they really differ? A retrospective observational study Ital. J. Pediatr. (IF 3.6) Pub Date : 2024-04-01 Salvatore Accomando, Ilenia Rita Piazza, Francesca Cacciatore, Veronica Notarbartolo, Giovanni Corsello, Mario Giuffrè
The aim of this study is to compare two groups of celiac patients: the first one, in which diagnosis was based on a “biopsy sparing” approach according to the 2012 ESPGHAN criteria, and the second one, based on the biopsy approach like the one of the 1991 Revised Criteria, in order to find relevant difference for sex, M/F ratio, age at diagnosis, clinical features at the onset, presence and prevalence
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Critical period of oxygen supplementation and invasive ventilation: implications for severe retinopathy of prematurity Ital. J. Pediatr. (IF 3.6) Pub Date : 2024-04-01 Ho Jung Choi, Baek Sup Shin, Seung Han Shin, Ee-Kyung Kim, Han-Suk Kim
Several studies have identified graded oxygen saturation targets to prevent retinopathy of prematurity (ROP), a serious complication in preterm infants. We aimed to analyze the critical period of oxygen supplementation and/or invasive ventilation associated with severe ROP. This retrospective case-control study included neonates with a gestational age (GA) < 29 weeks. Participants were divided into
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Clinical and economic burden of respiratory syncytial virus in children aged 0–5 years in Italy Ital. J. Pediatr. (IF 3.6) Pub Date : 2024-03-25 Melania Dovizio, Chiara Veronesi, Fausto Bartolini, Arturo Cavaliere, Stefano Grego, Romina Pagliaro, Cataldo Procacci, Loredana Ubertazzo, Lorenzo Bertizzolo, Barbara Muzii, Salvatore Parisi, Valentina Perrone, Eugenio Baraldi, Elena Bozzola, Fabio Mosca, Luca Degli Esposti
Respiratory syncytial virus (RSV) is among the leading causes of hospitalization due to lower respiratory tract infections (LRTIs) in children younger than 5 years worldwide and the second cause of infant death after malaria. RSV infection occurs in almost all the infants before the second year of life with variable clinical severity, often requiring medical assistance. This analysis investigated patients
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An epidemiological investigation of high-risk infants for Respiratory Syncytial Virus infections: a retrospective cohort study Ital. J. Pediatr. (IF 3.6) Pub Date : 2024-03-25 Michela Servadio, Marco Finocchietti, Chiara Vassallo, Riccardo Cipelli, Franca Heiman, Giulia Di Lucchio, Bianca Oresta, Antonio Addis, Valeria Belleudi
Respiratory Syncytial Virus (RSV) infections may lead to severe consequences in infants born preterm with breathing problems (such as bronchopulmonary dysplasia (BPD) and respiratory distress syndrome (RDS)) or congenital heart diseases (CHD). Since studies investigating the influence of different gestational age (WGA) and concomitant specific comorbidities on the burden of RSV infections are scarce
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The specialized pediatric palliative care service in Italy: how is it working? Results of the nationwide PalliPed study Ital. J. Pediatr. (IF 3.6) Pub Date : 2024-03-19 Franca Benini, Anna Mercante, Sara Di Nunzio, Simonetta Papa
Accurate estimation of the specialized pediatric palliative care (PPC) burden and the definition of the extent and quality of PPC service in Italy represent urgent needs to enable the proper allocation of PPC resources and the definition of prevention and educational plans. The PalliPed project aimed to provide the first comprehensive assessment of the characteristics of Italian patients requiring
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An association between heart rate variability and pediatric obstructive sleep apnea Ital. J. Pediatr. (IF 3.6) Pub Date : 2024-03-18 Nuntigar Sonsuwan, Krittika Houngsuwannakorn, Nipon Chattipakorn, Kittisak Sawanyawisuth
There are different findings on heart rate variability (HRV) and pediatric obstructive sleep apnea (pOSA) by an overnight HRV or a 1-hr HRV. However, there is limited data of HRV and pOSA diagnosis by using a 24-h HRV test. This study aimed to evaluate if HRV had potential for OSA diagnosis by using a 24-h HRV test. This was a prospective study included children age between 5 and 15 years old, presenting
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Factors associated with hospitalization in a pediatric population of rural Tanzania: findings from a retrospective cohort study Ital. J. Pediatr. (IF 3.6) Pub Date : 2024-03-18 Vincenzo Mancini, Martina Borellini, Paolo Belardi, Maria Carolina Colucci, Emanuel Yuda Kadinde, Christina Mwibuka, Donald Maziku, Pasquale Parisi, Anteo Di Napoli
Despite pediatric acute illnesses being leading causes of death and disability among children, acute and critical care services are not universally available in low-middle income countries, such as Tanzania, even if in this country significant progress has been made in child survival, over the last 20 years. In these countries, the hospital emergency departments may represent the only or the main point
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Plasma metabolomic profile in orthostatic intolerance children with high levels of plasma homocysteine Ital. J. Pediatr. (IF 3.6) Pub Date : 2024-03-14 Yaqi Li, Baoling Bai, Hui Wang, Haojie Wu, Yanjun Deng, Chen Shen, Qin Zhang, Lin Shi
Orthostatic intolerance, which includes vasovagal syncope and postural orthostatic tachycardia syndrome, is common in children and adolescents. Elevated plasma homocysteine levels might participate in the pathogenesis of orthostatic intolerance. This study was designed to analyze the plasma metabolomic profile in orthostatic intolerance children with high levels of plasma homocysteine. Plasma samples
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Italian guidelines for the management of irritable bowel syndrome in children and adolescents Ital. J. Pediatr. (IF 3.6) Pub Date : 2024-03-14 Giovanni Di Nardo, Giovanni Barbara, Osvaldo Borrelli, Cesare Cremon, Valentina Giorgio, Luigi Greco, Michele La Pietra, Giovanni Marasco, Licia Pensabene, Marisa Piccirillo, Claudio Romano, Silvia Salvatore, Michele Saviano, Vincenzo Stanghellini, Caterina Strisciuglio, Renato Tambucci, Rossella Turco, Letizia Zenzeri, Annamaria Staiano
The irritable bowel syndrome (IBS) is a functional gastrointestinal disorder (FGID), whose prevalence has widely increased in pediatric population during the past two decades. The exact pathophysiological mechanism underlying IBS is still uncertain, thus resulting in challenging diagnosis and management. Experts from 4 Italian Societies participated in a Delphi consensus, searching medical literature
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Etiological analysis of 167 cases of drug-resistant epilepsy in children Ital. J. Pediatr. (IF 3.6) Pub Date : 2024-03-13 Ran-Ran Zuo, Mei Jin, Su-Zhen Sun
To analyze the etiological distribution characteristics of drug-resistant epilepsy (DRE) in children, with the aim of providing valuable perspectives to enhance clinical practice. In this retrospective study, clinical data were collected on 167 children with DRE who were hospitalized between January 2020 and December 2022, including gender, age of onset, seizure types, video electroencephalogram(VEEG)
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The effect of parity on time to initiate complementary feeding among mother-infant pairs in Awi Zone, Northwest Ethiopia Ital. J. Pediatr. (IF 3.6) Pub Date : 2024-03-13 Tilahun Degu Tsega, Gashaw Melkie Bayeh, Kassaye Demeke Alemu, Abaynew Assemu Asrade, Abebaw Molla Kebede, Tamiru Alene, Zewdu Bishaw Aynalem, Bezawit Adane, Melaku Yalew, Molla Getie Mehari, Almaw Genet Yeshiwas, Tadesse Miretie Dessie, Eniyew Talie Fenta, Kefale Mitiku Haylu
Despite strategies and recommendations for complementary feeding initiation were applied globally, mothers initiated complementary feeding to the infants on time was low. Previous works of literatures were not identified the effect of parity on time to initiate complementary feeding. Particularly, evidences regarding to this in Ethiopia is scanty. Therefore, this study aimed to identify the effect
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Nursing management of patients dealing with spina bifida: from the prenatal diagnosis to adulthood / nursing intervention for the improvement of the impact of urinary and fecal incontinence on the quality of life of people dealing with spina bifida Ital. J. Pediatr. (IF 3.6) Pub Date : 2024-03-13 Fabiana Calabrese, Antonio Poziello, Gennaro Spiezia, Tiziana Rotunno, Ciro Chervino, Anna Maria Iannicelli
Urinary and fecal incontinence in people dealing with spina bifida, has inevitably an influence on the quality of life. In this analysis, the degree of education on how to manage incontinence and retention is studied, as well as the problems those might create and the consequential degree of autonomy and independence reached into the management of those. The main goal is to increase both nursing assistance
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Exercise-induced bronchoconstriction, allergy and sports in children Ital. J. Pediatr. (IF 3.6) Pub Date : 2024-03-13 Angela Klain, Mattia Giovannini, Luca Pecoraro, Simona Barni, Francesca Mori, Lucia Liotti, Carla Mastrorilli, Francesca Saretta, Riccardo Castagnoli, Stefania Arasi, Lucia Caminiti, Mariannita Gelsomino, Cristiana Indolfi, Michele Miraglia del Giudice, Elio Novembre
Exercise-induced bronchoconstriction (EIB) is characterized by the narrowing of airways during or after physical activity, leading to symptoms such as wheezing, coughing, and shortness of breath. Distinguishing between EIB and exercise-induced asthma (EIA) is essential, given their divergent therapeutic and prognostic considerations. EIB has been increasingly recognized as a significant concern in
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Critical illness-related corticosteroid insufficiency (CIRCI) in paediatric patients: a diagnostic and therapeutic challenge Ital. J. Pediatr. (IF 3.6) Pub Date : 2024-03-11 Letteria Anna Morabito, Domenico Corica, Giorgia Pepe, Alessandra Li Pomi, Tommaso Aversa, Malgorzata Gabriela Wasniewska
Critical illness-related corticosteroid insufficiency or CIRCI is characterized by acute and life-threatening disfunction of hypothalamic–pituitary–adrenal (HPA) axis observed among intensive care unit- staying patients. It is associated with increased circulating levels of biological markers of inflammation and coagulation, morbidity, length of ICU stay, and mortality. Several mechanisms are involved
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Respiratory syncytial virus-associated hospitalizations among children: an Italian retrospective observational study Ital. J. Pediatr. (IF 3.6) Pub Date : 2024-03-07 Francesca Fortunato, Angelo Campanozzi, Gianfranco Maffei, Fabio Arena, Valeria Delli Carri, Tiziana Rollo, Pier Luigi Lopalco, Domenico Martinelli
Respiratory syncytial virus (RSV), a single-stranded RNA virus, is a leading cause of hospitalization in infants, especially ≤ 2 months of life. In the light new immunization strategies adoption, we described epidemiological and clinical characteristics of RSV-associated hospitalizations in pediatric and neonatal intensive care units of the Policlinico Foggia Hospital, Apulia Region, Italy. Hospitalized
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Healthcare migration in Italian paediatric haematology-oncology centres belonging to AIEOP Ital. J. Pediatr. (IF 3.6) Pub Date : 2024-03-07 Roberto Rondelli, Tamara Belotti, Riccardo Masetti, Franco Locatelli, Maura Massimino, Alessandra Biffi, Carlo Dufour, Franca Fagioli, Giuseppe Menna, Andrea Biondi, Claudio Favre, Marco Zecca, Nicola Santoro, Giovanna Russo, Silverio Perrotta, Andrea Pession, Arcangelo Prete
In Italy, there is a network of centres headed by the Italian Association of Pediatric Hematology and Oncology (AIEOP) for the diagnosis and treatment of paediatric cancers on almost the entire national territory. Nevertheless, migration of patients in a hospital located in a region different from that of residence is a widespread habit, sometimes motivated by several reasons. The aim of this paper
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Distribution of blood lead and cadmium levels in healthy children aged 0 to 18 years and analysis of related influencing factors in Henan, China: data findings from 2017 to 2022 Ital. J. Pediatr. (IF 3.6) Pub Date : 2024-03-07 Hui Yan, Bo Zhai, Ruiling Feng, Penggao Wang, Fang Yang, Yang Zhou
There is still a lack of data on blood lead levels (BLLs) and blood lead levels (BLLs) in healthy children of all ages from 0 to 18 years in China. This study was performed to analyze the BLLs and BCLs in healthy children aged 0-18 years from 2017 to 2022 in urban and rural areas of Henan Province, Central China, as well as their relationships with socio-demographic variables and certain relevant exposure
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Pediatric asthma and altitude: a complex interplay between different environmental factors Ital. J. Pediatr. (IF 3.6) Pub Date : 2024-03-06 Laura Bisoffi, Giovanni Sassudelli, Fabio Agostinis, Annalisa Cogo, Renato Cutrera, Irene Dalpiaz, Maria Elisa Di Cicco, Battista Guidi, Stefania La Grutta, Andrea Miceli, Francesca Mori, Giorgio Piacentini, Diego Peroni, Deborah Snjiders, Mattia Giovannini, Ermanno Baldo
Asthma is one of the most common non-communicable diseases, and its prevalence and morbidity are influenced by a wide array of factors that are only partially understood. In addition to individual predisposition linked to genetic background and early life infections, environmental factors are crucial in determining the impact of asthma both on an individual patient and on a population level. Several
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Neonatal persistent pulmonary hypertension related to a novel TBX4 mutation: case report and review of the literature Ital. J. Pediatr. (IF 3.6) Pub Date : 2024-03-05 Chiara Maddaloni, Sara Ronci, Domenico Umberto De Rose, Iliana Bersani, Francesca Campi, Matteo Di Nardo, Francesca Stoppa, Rachele Adorisio, Antonio Amodeo, Alessandra Toscano, Maria Cristina Digilio, Antonio Novelli, Giovanni Chello, Annabella Braguglia, Andrea Dotta, Flaminia Calzolari
TBX4 gene, located on human chromosome 17q23.2, encodes for T-Box Transcription Factor 4, a transcription factor that belongs to the T-box gene family and it is involved in the regulation of some embryonic developmental processes, with a significant impact on respiratory and skeletal illnesses. Herein, we present the case of a female neonate with persistent pulmonary hypertension (PH) who underwent
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Fatal food anaphylaxis in adults and children Ital. J. Pediatr. (IF 3.6) Pub Date : 2024-03-05 Elio Novembre, Mariannita Gelsomino, Lucia Liotti, Simona Barni, Francesca Mori, Mattia Giovannini, Carla Mastrorilli, Luca Pecoraro, Francesca Saretta, Riccardo Castagnoli, Stefania Arasi, Lucia Caminiti, Angela Klain, Michele Miraglia del Giudice
Anaphylaxis is a life-threatening reaction characterized by the acute onset of symptoms involving different organ systems and requiring immediate medical intervention. The incidence of fatal food anaphylaxis is 0.03 to 0.3 million/people/year. Most fatal food-induced anaphylaxis occurs in the second and third decades of life. The identified risk factors include the delayed use of epinephrine, the presence
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Associations of maternal serum concentration of iron-related indicators with birth outcomes in Chinese: a pilot prospective cohort study Ital. J. Pediatr. (IF 3.6) Pub Date : 2024-03-05 Geng-dong Chen, Peng-sheng Li, Zi-xing Zhou, Hai-yan Wang, Xiao-yan Gou, Shao-xin Ye, Dong-xin Lin, Da-zhi Fan, Li-juan Wang, Zheng-ping Liu
Previous studies of maternal iron and birth outcomes have been limited to single indicators that do not reflect the comprehensive relationship with birth outcomes. We aimed to investigate the relationship between maternal iron metabolism and neonatal anthropometric indicators using comprehensive iron-related indicators. A total of 914 Chinese mother-child dyads were enrolled in this prospective study
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Efficacy of doxycycline therapy for macrolide-resistant Mycoplasma pneumoniae pneumonia in children at different periods Ital. J. Pediatr. (IF 3.6) Pub Date : 2024-03-05 Ying Chen, Yan Zhang, Qiong-Ni Tang, Hong-Bo Shi
The prevalence of macrolide-resistant Mycoplasma pneumoniae has increased considerably. Treatment in children has become challenging. This study aimed to evaluate the efficacy of doxycycline therapy for macrolide-resistant Mycoplasma pneumoniae pneumonia in children at different periods. We retrospectively analyzed the data of patients with macrolide-resistant Mycoplasma pneumoniae pneumonia hospitalized
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Efficacy of home phototherapy versus inpatient phototherapy for neonatal hyperbilirubinemia: a systematic review and meta-analysis Ital. J. Pediatr. (IF 3.6) Pub Date : 2024-03-04 Rui Li, Tingting Li, Xudong Yan, Jing Feng, Zhangbin Yu, Cheng Chen
Home phototherapy (HPT) remains a contentious alternative to inpatient phototherapy (IPT) for neonatal hyperbilirubinemia. To guide evidence-based clinical decision-making, we conducted a meta-analysis of randomized clinical trials (RCTs) and cohort studies and assessed the comparative risks and benefits of HPT and IPT. PubMed, Embase, Web of Science, Cochrane Library, Chinese National Knowledge Infrastructure
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Imported allergens in Italy: an emerging issue Ital. J. Pediatr. (IF 3.6) Pub Date : 2024-03-03 Luca Pecoraro, Mattia Giovannini, Francesca Mori, Simona Barni, Riccardo Castagnoli, Stefania Arasi, Carla Mastrorilli, Francesca Saretta, Lucia Liotti, Lucia Caminiti, Angela Klain, Mariannita Gelsomino, Michele Miraglia Del Giudice, Elio Novembre
Imported allergens are involved in many allergic reactions, with unexpected and unusual implications. They can be involved in developing asthma, allergic rhinoconjunctivitis, Hymenoptera venom allergies and food allergies. Imported allergens can be implied in respiratory allergies attributable to commercial practices and accidental diffusion through air currents that have introduced non-native species
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Knowledge, attitudes and behaviours of a sample of Italian paediatricians towards RSV and its preventive strategies: a cross-sectional study Ital. J. Pediatr. (IF 3.6) Pub Date : 2024-02-29 Giulia Congedo, Gaia Surya Lombardi, Doris Zjalic, Mattia Di Russo, Emanuele La Gatta, Luca Regazzi, Giuseppe Indolfi, Annamaria Staiano, Chiara Cadeddu
Respiratory Syncytial Virus (RSV) infection mainly affects newborns, infants and young children aged < 2 years. Since an RSV vaccine is in the European Medicines Agency’s waitlist validation, nowadays the prevention only includes passive immunization with monoclonal antibodies (mAb). In the present study we aimed at investigating Italian paediatricians’ knowledge, attitudes and behaviours towards RSV
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The long-term neurodevelopmental outcomes of toddlers with SARS-CoV-2 infection in the neonatal period: a prospective observational study Ital. J. Pediatr. (IF 3.6) Pub Date : 2024-02-27 Ezgi Yangin Ergon, Senem Alkan Ozdemir, Sinem Akbay Ak, Meltem Yenilmez, Buse Soysal, Oğuz Han Kalkanlı, Şebnem Çalkavur, Tülin Gokmen Yıldırım
The effect of Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) virus in the neonatal period on developing brain is still unknown. This study aims to investigate the long-term neurodevelopmental outcomes of newborns exposed to SARS-CoV-2 & Delta variant. At a tertiary referral center, a prospective observational cohort research was carried out. All babies who were equal to or more than 34
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Pediatric acute hospitalization for anorexia nervosa: an economic evaluation Ital. J. Pediatr. (IF 3.6) Pub Date : 2024-02-27 Maria Rosaria Marchili, Elena Bozzola, Stefano Guolo, Silvio Marchesani, Giulia Spina, Cristina Mascolo, Stefano Vicari, Isabella Tarissi De Jacobis, Massimiliano Raponi, Alberto Villani
Anorexia nervosa (AN) is a psychiatric disorders which may potentially led to a high risk of health medical complications, suicide and self-harming behaviour. Since Covid-19 pandemic onset in March 2020, evidence suggested an increase occurrence of AN. The main aim of the retrospective analysis is to define the cost of hospitalization in the acute phase (HAP) at IRCCS Bambino Gesù Children Hospital
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Use of Remdesivir in children with COVID-19: report of an Italian multicenter study Ital. J. Pediatr. (IF 3.6) Pub Date : 2024-02-27 Lorenza Romani, Marco Roversi, Stefania Bernardi, Elisabetta Venturini, Silvia Garazzino, Daniele Donà, Andrzej Krzysztofiak, Carlotta Montagnani, Elisa Funiciello, Francesca Ippolita Calò Carducci, Caterina Marabotto, Elio Castagnola, Filippo Salvini, Laura Lancella, Andrea Lo Vecchio, Luisa Galli, Guido Castelli Gattinara
COVID-19 is generally milder in children than in adults, however severe infection has been described in some patients. Few data are available on use of Remdesivir (RDV) in children, as most clinical trials focused on adult patients. We report a multicenter study conducted in 10 Italian Hospitals to investigate the safety of RDV in children affected by COVID-19. We collected the clinical data of children
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Prevalence of extended-spectrum beta-lactamase and molecular detection of blaTEM, blaSHV, and blaCTX-M genotypes among gram-negative Bacilli isolates from hospital acquired infections in pediatrics, one institutional study Ital. J. Pediatr. (IF 3.6) Pub Date : 2024-02-24 Ahmed Gomaa Ahmed Elsayed, Dina F. Badr, Nermene Youssef Abo El Kheir, Maysaa El Sayed Zaki, Abdelrahman Eid Mahmoud Mossad, Ehab Mohammed Fahmy Mahmoud
Gram-negative bacilli represents an important pathogen in hospital-acquired infections (HAIs) worldwide. The emergence of antibiotic resistance in these pathogens warrants attention for the proper management of infections. Extended-spectrum beta-lactamase (ESBL) resistance represents a major therapeutic problem in infections due to Gram-negative bacilli. The present study aimed to study the extended-spectrum
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Recurrent upper respiratory tract infections in early childhood: a newly defined clinical condition Ital. J. Pediatr. (IF 3.6) Pub Date : 2024-02-16 Antonio Corsello, Gregorio Paolo Milani, Marina Picca, Roberto Buzzetti, Romeo Carrozzo, Mirko Gambino, Giovanni Chiaffoni, Paola Marchisio, Chiara Mameli
Recurrent Upper Respiratory Tract Infections (R-URTIs) pose a significant challenge in pediatric healthcare, affecting both children and their families. This study aimed to investigate the prevalence, risk factors, and clinical implications of R-URTI in children aged 0–5 years. This observational study involved a sample of 483 children aged 0–5 years, focusing on establishing a practical and dynamic
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Record of strep throat infections in Italy: what is needed to know about penicillin allergy? The point of view from the Italian Society of Pediatric Allergy and Immunology (SIAIP) Ital. J. Pediatr. (IF 3.6) Pub Date : 2024-02-14 Maria De Filippo, Angela Klain, Ilaria Brambilla, Silvia Caimmi, Riccardo Castagnoli, Cristiana Indolfi, Giulio Dinardo, Amelia Licari, Alberto Martelli, Maria Angela Tosca, Martina Votto, Gian Luigi Marseglia, Michele Miraglia del Giudice
Notifications of invasive group A streptococcal (iGAS) infections have significantly increased in many European Countries compared to the previous season. In Italy, there has been an increase in streptococcal pharyngitis and scarlet fever cases since January 2023, which sparked concerns about a GAS epidemic in the pediatric population. This rise may be ascribed to the GAS infection season that began
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The mechanisms of milder clinical symptoms of COVID-19 in children compared to adults Ital. J. Pediatr. (IF 3.6) Pub Date : 2024-02-14 Caiyin Luo, Wanwen Chen, Junying Cai, Yuwen He
In stark contrast to adult patients, children who contract Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) typically manifest milder symptoms or remain asymptomatic. However, the precise underlying mechanisms of this pathogenesis remain elusive. In this review, we primarily retrospect the clinical characteristics of SARS-CoV-2 infection in children, and explore the factors that may contribute