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Pathogenic spectrum and risk factors of peritoneal dialysis-associated peritonitis: a single-center retrospective study BMC Infect. Dis. (IF 3.7) Pub Date : 2024-04-25 Linshuang You, Baoguo Zhang, Fan Zhang, Jianwen Wang
The present study aimed to explore the pathogenic spectrum and risk factors of peritoneal dialysis-associated peritonitis (Peritoneal dialysis associated peritonitis, PDAP) in Yongzhou, Hunan, China. The clinical and epidemiological data on regular peritoneal dialysis (Peritoneal dialysis, PD) between January 2016 and December 2020 in Yongzhou were collected for retrospective analysis. The related
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Application and evaluation of topical amphotericin B for the treatment of respiratory fungal infections BMC Infect. Dis. (IF 3.7) Pub Date : 2024-04-24 Ning Cui, Jingming Zhao
In recent years, the prevalence of respiratory fungal diseases has increased. Polyene antifungal drugs play a pivotal role in the treatment of these conditions, with amphotericin B (AmB) being the most representative drug. This study aimed to evaluate the efficacy and safety of topical administration of AmB in the treatment of respiratory fungal infections. We conducted a retrospective study on hospitalized
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Herpes zoster (HZ) vaccine coverage and confidence in Italy: a Nationwide cross-sectional study, the OBVIOUS project BMC Infect. Dis. (IF 3.7) Pub Date : 2024-04-24 Aurelia Salussolia, Angelo Capodici, Francesca Scognamiglio, Giusy La Fauci, Giorgia Soldà, Marco Montalti, Zeno Di Valerio, Maria Pia Fantini, Anna Odone, Claudio Costantino, Heidi J. Larson, Julie Leask, Jacopo Lenzi, Davide Gori
Herpes Zoster is an age dependent disease and as such it represents a problem in the Italian social context, where the demographic curve is characterized by an overrepresentation of the elderly population. Vaccines against Herpes Zoster are available, safe and effective, however coverage remains sub-optimal. This study was therefore conducted to examine the variations in Herpes Zoster vaccine uptake
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Disseminated mycobacterium genavense infection with central nervous system involvement in an HIV patient: a case report and literature review BMC Infect. Dis. (IF 3.7) Pub Date : 2024-04-24 Ali Hassanzadeh, Malihe Hasannezhad, Ladan Abbasian, Sara Ghaderkhani, Fereshteh Ameli, Mehdi Allahdadi
Immunodeficient patients, particularly HIV patients, are at risk of opportunistic infections. Nontuberculous mycobacteria can cause severe complications in immunodeficient patients. We describe a 57-year-old HIV patient, primarily presented with coughs and constitutional symptoms, with a unique Mycobacterium genavense abdominal, pulmonary, and central nervous system infection, accompanied by intracranial
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Follow-up SARS-CoV-2 serological study of a health care worker cohort following COVID-19 booster vaccination BMC Infect. Dis. (IF 3.7) Pub Date : 2024-04-24 Alexander Hönning, Sara Tomczyk, Julia Hermes, Marica Grossegesse, Natalie Hofmann, Janine Michel, Markus Neumann, Andreas Nitsche, Berthold Hoppe, Tim Eckmanns, Hajo Schmidt-Traub, Kristina Zappel
Studies have shown that Omicron breakthrough infections can occur at higher SARS-CoV-2 antibody levels compared to previous variants. Estimating the magnitude of immunological protection induced from COVID-19 vaccination and previous infection remains important due to varying local pandemic dynamics and types of vaccination programmes, particularly among at-risk populations such as health care workers
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Soil-transmitted helminths and associated factors among pregnant women in Doreni district, Oromia region, Ethiopia: a cross-sectional study BMC Infect. Dis. (IF 3.7) Pub Date : 2024-04-24 Adamu Tesfa Mekonen, Teshome Bekana Hirpha, Asrat Zewdie
Soil-transmitted helminthiasis (STH) refers to a set of parasitic illnesses caused by nematode worms and spread to people through faeces-contaminated soil. It is highly prevalent in low- and middle-income countries due to a lack of environmental sanitation and personal hygiene. Pregnant women are among the risk groups for infection by soil-transmitted helminths. Former studies of the disease burden
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Antimicrobial activity of cefepime-tazobactam combination against extended spectrum beta-lactamase and/or AmpC beta-lactamase- producing gram-negative bacilli BMC Infect. Dis. (IF 3.7) Pub Date : 2024-04-23 Basma Ahmed Elawady, Noha Refaat Mahmoud, Hala El-Sayed Badawi, Azza Essam Eldin Badr, Noha Mahmoud Gohar
The problem of resistance to beta-lactam antibiotics, which is caused by ESBL and AmpC β-lactamases, is getting worse globally. Infections caused by bacterial isolates harboring these enzymes are difficult to treat with carbapenems being the sole effective treatment option for such infections. The objective of this study was to determine the frequency of ESBLs and AmpC-producing Gram-negative bacilli
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A challenging case of carbapenem resistant Klebsiella pneumoniae-related pyogenic liver abscess with capsular polysaccharide hyperproduction: a case report BMC Infect. Dis. (IF 3.7) Pub Date : 2024-04-23 Maryam Sohrabi, Neda Pirbonyeh, Mahvash Alizade Naini, Alireza Rasekhi, Abbas Ayoub, Zahra Hashemizadeh, Fereshteh Shahcheraghi
Carbapenem-resistant Klebsiella pneumoniae (CRKP) infections are a major public health problem, necessitating the administration of polymyxin E (colistin) as a last-line antibiotic. Meanwhile, the mortality rate associated with colistin-resistant K. pneumoniae infections is seriously increasing. On the other hand, importance of administration of carbapenems in promoting colistin resistance in K. pneumoniae
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Seasonality of influenza-like illness and short-term forecasting model in Chongqing from 2010 to 2022 BMC Infect. Dis. (IF 3.7) Pub Date : 2024-04-23 Huayong Chen, Mimi Xiao
Influenza-like illness (ILI) imposes a significant burden on patients, employers and society. However, there is no analysis and prediction at the hospital level in Chongqing. We aimed to characterize the seasonality of ILI, examine age heterogeneity in visits, and predict ILI peaks and assess whether they affect hospital operations. The multiplicative decomposition model was employed to decompose the
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Gut microbial features may influence antiviral IgG levels after vaccination against viral respiratory infectious diseases: the evidence from two-sample bidirectional mendelian randomization BMC Infect. Dis. (IF 3.7) Pub Date : 2024-04-23 Junlan Tu, Yidi Wang, Xiangyu Ye, Yifan Wang, Yixin Zou, Linna Jia, Sheng Yang, Rongbin Yu, Wei Liu, Peng Huang
Vaccination is effective in preventing viral respiratory infectious diseases through protective antibodies and the gut microbiome has been proven to regulate human immunity. This study explores the causal correlations between gut microbial features and serum-specific antiviral immunoglobulin G (IgG) levels. We conduct a two-sample bidirectional Mendelian randomization (MR) analysis using genome-wide
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Liver injury and prolonged hospitalization as indicators of severity in patients with adenovirus infections BMC Infect. Dis. (IF 3.7) Pub Date : 2024-04-22 Shi Tang, Ru Qin, Dayong Zhang, Xiaoyan He, Chaowen Yu, Dapeng Chen, Xiaoqiang Li, Shan Liu
Adenovirus (ADV) is a prevalent infective virus in children, accounting for around 5–10% of all cases of acute respiratory illnesses and 4–15% of pneumonia cases in children younger than five years old. Without treatment, severe ADV pneumonia could result in fatality rates of over 50% in cases of emerging strains or disseminated disease. This study aims to uncover the relationship of clinical indicators
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Evaluation of angiotensin converting enzyme 2 (ACE2), angiotensin II (Ang II), miR-141-3p, and miR-421 levels in SARS-CoV-2 patients: a case-control study BMC Infect. Dis. (IF 3.7) Pub Date : 2024-04-22 Ehsan Kakavandi, Kaveh Sadeghi, Mohammad Shayestehpour, Hossein Mirhendi, Abbas Rahimi Foroushani, Talat Mokhtari-Azad, Nazanin Zahra Shafiei Jandaghi, Jila Yavarian
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a highly contagious virus that uses angiotensin converting enzyme 2 (ACE2), a pivotal member of the renin–angiotensin system (RAS), as its cell-entry receptor. Another member of the RAS, angiotensin II (Ang II), is the major biologically active component in this system. There is growing evidence suggesting that serum miRNAs could serve
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Characteristics and outcomes of COVID-19 patients presumed to be treated with sotrovimab in NHS hospitals in England BMC Infect. Dis. (IF 3.7) Pub Date : 2024-04-22 Vishal Patel, Bethany Levick, Stephen Boult, Daniel C. Gibbons, Myriam Drysdale, Emily J. Lloyd, Moushmi Singh, Helen J. Birch
The impact of the constantly evolving severe acute respiratory syndrome coronavirus 2 on the effectiveness of early coronavirus disease 2019 (COVID-19) treatments is unclear. Here, we report characteristics and acute clinical outcomes of patients with COVID-19 treated with a monoclonal antibody (mAb; presumed to be sotrovimab) across six distinct periods covering the emergence and predominance of Omicron
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COVID-19 increases extracorporeal coagulation during hemodialysis associated with upregulation of vWF/FBLN5 signaling in patients with severe/critical symptoms BMC Infect. Dis. (IF 3.7) Pub Date : 2024-04-22 Guang Yang, Hui Shan, Dibin Wu, Sanmu Li, Zhiwei Lai, Fengping Zheng, Zibo Xiong, Zuying Xiong, Yuhan Diao, Ying Shan, Yun Chen, Aihong Wang, Wei Liang, Yuxin Yin
COVID-19 has been shown to increase the risk of extracorporeal coagulation during hemodialysis in patients, but the underlying mechanism remains unclear. This study aimed to investigate the effect and mechanism of COVID-19 on the risk of extracorporeal coagulation in patients with chronic kidney disease undergoing hemodialysis. A retrospective analysis of the extracorporeal coagulation status of 339
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Epidemiological and etiological characteristics of 1266 patients with severe acute respiratory infection in central China, 2018–2020: a retrospective survey BMC Infect. Dis. (IF 3.7) Pub Date : 2024-04-22 Jin-Zhu Wang, Ding Yuan, Xiang-Hong Yang, Chang-Hua Sun, Lin-lin Hou, Yan Zhang, Hong-Xiang Xie, Yan-Xia Gao
Severe acute respiratory infection (SARI), a significant global health concern, imposes a substantial disease burden. In China, there is inadequate data concerning the monitoring of respiratory pathogens, particularly bacteria, among patients with SARI. Therefore, this study aims to delineate the demographic, epidemiological, and aetiological characteristics of hospitalised SARI patients in Central
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Necrotising fasciitis with extensive necrosis caused by Lactobacillus: a case report BMC Infect. Dis. (IF 3.7) Pub Date : 2024-04-22 Jun Nagayama, Takeo Sato, Ishida Takanori, Koga Kouji, Nakamura Mitsunobu
Necrotising fasciitis (NF) is a life-threatening soft-tissue infection that rapidly destroys the epidermis, subcutaneous tissue, and fascia. Despite their low virulence, Lactobacillus spp. can cause NF, and because of its rare incidence, there is limited information about its molecular and clinicopathological characteristics. We report a rare case of NF in a patient with type 2 diabetes mellitus diagnosed
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Outcomes in orthopedic device infections due to Streptococcus agalactiae: a retrospective cohort study BMC Infect. Dis. (IF 3.7) Pub Date : 2024-04-22 Ava Diarra, Benoit Gachet, Eric Beltrand, Julien Dartus, Caroline Loiez, Elise Fiaux, Pierre Patoz, Olivier Robineau, Eric Senneville
Group B streptococci (Streptococcus agalactiae) (GBS) is a rare cause of prosthetic joint infection (PJI) occurring in patients with comorbidities and seems to be associated with a poor outcome. Depiction of GBS PJI is scarce in the literature. A retrospective survey in 2 referral centers for bone joint infections was done Patients with a history of PJI associated with GBS between 2014 and 2019 were
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Stigma and mental health among people living with HIV across the COVID-19 pandemic: a cross-sectional study BMC Infect. Dis. (IF 3.7) Pub Date : 2024-04-22 Francesco Di Gennaro, Roberta Papagni, Francesco Vladimiro Segala, Carmen Pellegrino, Gianfranco Giorgio Panico, Luisa Frallonardo, Lucia Diella, Alessandra Belati, Carmen Rita Santoro, Gaetano Brindicci, Flavia Balena, Davide Fiore Bavaro, Domenico Montalbò, Giacomo Guido, Lina Calluso, Marilisa Di Tullio, Margherita Sgambati, Deborah Fiordelisi, Nicolò De Gennaro, Annalisa Saracino
Mental health (MH) is extremely relevant when referring to people living with a chronic disease, such as people living with HIV (PLWH). In fact – although life expectancy and quality have increased since the advent of antiretroviral therapy (ART) – PLWH carry a high incidence of mental disorders, and this burden has been exacerbated during the COVID-19 pandemic. In this scenario, UNAIDS has set new
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Post-COVID reactivation of latent Bartonella henselae infection: a case report and literature review BMC Infect. Dis. (IF 3.7) Pub Date : 2024-04-22 Yanzhao Dong, Ahmad Alhaskawi, Xiaodi Zou, Haiying Zhou, Sohaib Hasan Abdullah Ezzi, Vishnu Goutham Kota, Mohamed Hasan Abdulla Hasan Abdulla, Alenikova Olga, Sahar Ahmed Abdalbary, Hui Lu
Cat scratch disease (CSD) is caused by Bartonella henselae (B. henselae) and presents as lymphadenopathy following close contact with cats. However, in context of the global COVID-19 pandemic, clinical manifestations of CSD may vary, posing new challenges for healthcare professionals. Here we describe a case of a 54-year-old male with painful left upper arm mass, which gradually resolved until he was
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Predictors of mortality and poor outcome for patients with severe infectious encephalitis in the intensive care unit: a cross-sectional study BMC Infect. Dis. (IF 3.7) Pub Date : 2024-04-22 WenYan Zhao, YuLiang Zhou, YingYing Hu, WenJing Luo, Jing Wang, Hong Zhu, ZhiPeng Xu
There are few thorough studies assessing predictors of severe encephalitis, despite the poor prognosis and high mortality associated with severe encephalitis. The study aims to evaluate the clinical predictors of mortality and poor outcomes at hospital discharge in patients with severe infectious encephalitis in intensive care units. In two Chinese hospitals, a retrospective cohort study comprising
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Exploring variations in IPC competencies: a cross-sectional study among healthcare professionals in Northwest China BMC Infect. Dis. (IF 3.7) Pub Date : 2024-04-22 Qinglan Zhao, Xiaoqing Cui, Ting Liu, Hanxue Li, Miaoyue Shi, Li Wang
This cross-sectional study investigates infection prevention and control (IPC) competencies among healthcare professionals in northwest China, examining the influence of demographic factors, job titles, education, work experience, and hospital levels. Data from 874 respondents across 47 hospitals were collected through surveys assessing 16 major IPC domains. Statistical analyses, including Mann-Whitney
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Comparison of outcomes and characteristics of patients admitted to the ICU with COVID-19 and other community-acquired pneumonia based on propensity score matching BMC Infect. Dis. (IF 3.7) Pub Date : 2024-04-22 Hongli Zhao, Xiulin Yan, Ziru Guo, Kaiyu Li, Zhaopeng Wang, Jun Wang, Dong Lv, Jianling Zhu, Ye Chen
To compare the similarities and differences between patients with Coronavirus Disease 2019 (COVID-19) and those with other community-acquired pneumonia (CAP) admitted to the intensive care unit (ICU), utilizing propensity score matching (PSM), regarding hospitalization expenses, treatment options, and prognostic outcomes, aiming to inform the diagnosis and treatment of COVID-19. Patients admitted to
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Cost-utility analysis of palivizumab for preventing respiratory syncytial virus in preterm neonates and infants in Colombia BMC Infect. Dis. (IF 3.7) Pub Date : 2024-04-19 Jaime E. Ordóñez, Victor M. Huertas
Palivizumab has proven effective in reducing hospitalizations, preventing severe illness, improving health outcomes, and reducing healthcare costs for infants at risk of respiratory syncytial virus (RSV) infection. We aim to assess the value of palivizumab in preventing RSV infection in high-risk infants in Colombia, where RSV poses a significant threat, causing severe respiratory illness and hospitalizations
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Comparison of safety and effectiveness of antiretroviral therapy regimens among pregnant women living with HIV at preconception or during pregnancy: a systematic review and network meta-analysis of randomized trials BMC Infect. Dis. (IF 3.7) Pub Date : 2024-04-19 Fatemeh Mehrabi, Mohammad Karamouzian, Behnam Farhoudi, Shahryar Moradi Falah Langeroodi, Soheil Mehmandoost, Samaneh Abbaszadeh, Shahrzad Motaghi, Ali Mirzazadeh, Behnam Sadeghirad, Hamid Sharifi
Mother-to-child transmission is the primary cause of HIV cases among children. Antiretroviral therapy (ART) plays a critical role in preventing mother-to-child transmission and reducing HIV progression, morbidity, and mortality among mothers. However, after more than two decades of ART during pregnancy, the comparative effectiveness and safety of ART medications during pregnancy are unclear, and existing
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Prevalence and factors associated with HIV testing among young women in Ghana BMC Infect. Dis. (IF 3.7) Pub Date : 2024-04-19 Mainprice Akuoko Essuman, Hidaya Mohammed, Martha Suntah Kebir, Comfort Obiribea, Bright Opoku Ahinkorah
HIV/AIDS is a global health challenge and continues to threaten lives in sub-Saharan African countries such as Ghana. One of the important interventions for controlling its transmission is through testing and receiving medication. In this study, we present findings on the prevalence and factors associated with HIV testing among young women in Ghana. We used data from the 2014 Ghana Demographic and
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Key informant views on potential acceptability and feasibility of long-acting antiretroviral treatment for HIV in Kenya BMC Infect. Dis. (IF 3.7) Pub Date : 2024-04-19 Anne Kaggiah, Catherine N. Maina, John Kinuthia, Douglas Barthold, Brett Hauber, Jacinda Tran, Jane M. Simoni, Susan M. Graham
In 2020, 14% of diagnosed persons living with HIV (PLWH) in Kenya were not taking antiretroviral therapy (ART), and 19% of those on ART had unsuppressed viral loads. Long-acting antiretroviral therapy (LA-ART) may increase viral suppression by promoting ART uptake and adherence. We conducted key informant (KI) interviews with HIV experts in Kenya to identify product and delivery attributes related
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Early predictors of delayed radiographic resolution of lobar pneumonia caused by Mycoplasma pneumoniae in children: a retrospective study in China BMC Infect. Dis. (IF 3.7) Pub Date : 2024-04-19 Yu Zheng, Guoshun Mao, Hongchen Dai, Guitao Li, Liying Liu, Xiaying Chen, Ying Zhu
Lobar pneumonia caused by Mycoplasma pneumoniae is a relatively difficult-to-treat pneumonia in children. The time of radiographic resolution after treatment is variable, a long recovery time can result in several negative effects, and it has attracted our attention. Therefore, exploring factors associated with delayed radiographic resolution will help to identify these children at an early stage and
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Immunogenicity and safety of a recombinant COVID-19 vaccine (ZF2001) as heterologous booster after priming with inactivated vaccine in healthy children and adolescents aged 3-17 years: an open-labeled, single-arm clinical trial BMC Infect. Dis. (IF 3.7) Pub Date : 2024-04-19 Tao Huang, Qianqian Hu, Xiang Zhou, Huaiyu Yang, Wei Xia, Feng Cao, Minglu Deng, Xiaoxue Teng, Fan Ding, Zaixin Zhong, Lidong Gao, Jiufeng Sun, Lihui Gong
Considering that neutralizing antibody levels induced by two doses of the inactivated vaccine decreased over time and had fallen to low levels by 6 months, and homologous and heterologous booster immunization programs have been implemented in adults in China. The booster immunization of recombinant COVID-19 vaccine (ZF2001) after priming with inactivated vaccine in healthy children and adolescents
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Virulence, antibiotic resistance phenotypes and molecular characterisation of Vibrio furnissii isolates from patients with diarrhoea BMC Infect. Dis. (IF 3.7) Pub Date : 2024-04-19 Yanyan Zhou, Li Yu, Ming Liu, Weili Liang, Zhenpeng Li, Zheng Nan, Biao Kan
Vibrio furnissii is an emerging human pathogen closely related to V. fluvialis that causes acute gastroenteritis. V. furnissii infection has been reported to be rarer than V. fluvialis, but a multi-drug resistance plasmid has recently been discovered in V. furnissii. During daily monitoring at a general hospital in Beijing, China, seven V. furnissii strains were collected from patients aged over 14
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The predictive power of data: machine learning analysis for Covid-19 mortality based on personal, clinical, preclinical, and laboratory variables in a case–control study BMC Infect. Dis. (IF 3.7) Pub Date : 2024-04-18 Maryam Seyedtabib, Roya Najafi-Vosough, Naser Kamyari
The COVID-19 pandemic has presented unprecedented public health challenges worldwide. Understanding the factors contributing to COVID-19 mortality is critical for effective management and intervention strategies. This study aims to unlock the predictive power of data collected from personal, clinical, preclinical, and laboratory variables through machine learning (ML) analyses. A retrospective study
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Seromolecular study on the prevalence and risk factors of Toxoplasma gondii infection in pregnant women referred to a gynecology hospital in Urmia, northwest part of Iran in 2022 BMC Infect. Dis. (IF 3.7) Pub Date : 2024-04-17 Nasim Bashour, Arash Aminpour, Shabnam Vazifehkhah, Rasool Jafari
Toxoplasmosis is a frequent infection among the human population. The infection can cause devastating complications for the fetus during pregnancy. The present study aimed to determine the serological and molecular prevalence of the infection and molecular characterization of Toxoplasma gondii isolates among pregnant women referred to Kowsar Hospital, Urmia, Iran. In a cross-sectional study, 340 blood
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Utility of paired plasma and drainage fluid mNGS in diagnosing acute intra-abdominal infections with sepsis BMC Infect. Dis. (IF 3.7) Pub Date : 2024-04-17 Jia-yu Mao, Dong-kai Li, Dong Zhang, Qi-wen Yang, Yun Long, Na Cui
Metagenomic next-generation sequencing (mNGS) has been increasingly applied in sepsis. We aimed to evaluate the diagnostic and therapeutic utility of mNGS of paired plasma and peritoneal drainage (PD) fluid samples in comparison to culture-based microbiological tests (CMTs) among critically ill patients with suspected acute intra-abdominal infections (IAIs). We conducted a prospective study from October
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Effect of concurrent infection of Helicobacter pylori with Toxoplasma gondii infection on gastric pathology BMC Infect. Dis. (IF 3.7) Pub Date : 2024-04-16 Marwa A. Gouda, Sara A. Saied, Ahmed Edrees, Rasha Galal Mostafa, Ashraf Elfert, Aya Abdallah seleem, Asmaa Shams, Sameh Afify
Toxoplasma gondii (T. gondii) and Helicobacter pylori (H. pylori) are among the most prevalent foodborne parasitic and bacterial infections worldwide. However, the concurrent impact of coinfection on gastric pathology has yet to be studied in depth. The effect of coinfection generally either adds a synergetic or antagonistic impact; we aimed in the current work to assess the impact of T. gondii coinfection
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Modelling the impact of hybrid immunity on future COVID-19 epidemic waves BMC Infect. Dis. (IF 3.7) Pub Date : 2024-04-16 Thao P. Le, Isobel Abell, Eamon Conway, Patricia T. Campbell, Alexandra B. Hogan, Michael J. Lydeamore, Jodie McVernon, Ivo Mueller, Camelia R. Walker, Christopher M. Baker
Since the emergence of SARS-CoV-2 (COVID-19), there have been multiple waves of infection and multiple rounds of vaccination rollouts. Both prior infection and vaccination can prevent future infection and reduce severity of outcomes, combining to form hybrid immunity against COVID-19 at the individual and population level. Here, we explore how different combinations of hybrid immunity affect the size
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Implementation of a rapid diagnostic assay package for cryptococcosis, histoplasmosis and tuberculosis in people living with HIV in Paraguay BMC Infect. Dis. (IF 3.7) Pub Date : 2024-04-16 Gloria Aguilar, Gladys Lopez, Omar Sued, Narda Medina, Diego H. Caceres, Jose Pereira, Alexander Jordan, Virgilio Lezcano, Cristina Vicenti, Gustavo Benitez, Tania Samudio, Freddy Perez
Opportunistic infections (OIs) are common causes of mortality among people living with HIV (PLHIV). We determined prevalence and 30-day mortality due to histoplasmosis, cryptococcosis, and TB in PLHIV with advanced HIV disease (AHD). PLHIV 18 years and older, with a CD4 + T-cell count of less than 350 cells/mm3 newly diagnosed with HIV infection or re-engaged in care after being without ART for more
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Characterization of genital chlamydia trachomatis infection among women attending infertility and gynecology clinics in Hunan, China BMC Infect. Dis. (IF 3.7) Pub Date : 2024-04-15 Qianting Zhou, Jiayan Li, Lipei Luo, Shuling Min, Li Wang, Lixiu Peng, Yinglan Hou, Ping He, Song He, Shixing Tang, Hongliang Chen
Genital infection with Chlamydia trachomatis (C. trachomatis) is a major public health issue worldwide. It can lead to cervicitis, urethritis, and infertility. This study was conducted to determine the characteristics of genital C. trachomatis infection among women attending to the infertility and gynecology clinics. Endocervical swabs were collected from 8,221 women for C. trachomatis nucleotide screening
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Unexpected severe malaria in a postoperative patient, New York, USA BMC Infect. Dis. (IF 3.7) Pub Date : 2024-04-15 Alan Bulbin, Julia Shen, Carol Liotta-Bono, Tahir Ahmad
Severe malaria is not routinely considered when evaluating a febrile patient in the postoperative setting. Common bacterial infections, along with adverse drug reactions, are the usual differential concerns. We present a case of severe malaria emerging unexpectedly eight days after routine craniotomy.
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The global patent landscape of emerging infectious disease monkeypox BMC Infect. Dis. (IF 3.7) Pub Date : 2024-04-15 Yuanqi Cai, Xiaoming Zhang, Kuixing Zhang, Jingbo Liang, Pingping Wang, Jinyu Cong, Xin Xu, Mengyao li, Kunmeng Liu, Benzheng Wei
Monkeypox is an emerging infectious disease with confirmed cases and deaths in several parts of the world. In light of this crisis, this study aims to analyze the global knowledge pattern of monkeypox-related patents and explore current trends and future technical directions in the medical development of monkeypox to inform research and policy. A comprehensive study of 1,791 monkeypox-related patents
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A systematic review and meta-analysis of circulating serum and plasma microRNAs in TB diagnosis BMC Infect. Dis. (IF 3.7) Pub Date : 2024-04-15 Harinisri Gunasekaran, Pavithra Sampath, Kannan Thiruvengadam, Muniyandi Malaisamy, Rathinasabapati Ramasamy, Uma Devi Ranganathan, Ramalingam Bethunaickan
Tuberculosis (TB) ranks as the second leading cause of death globally among all infectious diseases. This problem is likely due to the lack of biomarkers to differentiate the heterogeneous spectrum of infection. Therefore, the first step in solving this problem is to identify biomarkers to distinguish the different disease states of an individual and treat them accordingly. Circulating microRNA (miRNA)
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Increased tuberculosis case detection in Tanzanian children and adults using African giant pouched rats BMC Infect. Dis. (IF 3.7) Pub Date : 2024-04-15 Tefera B. Agizew, Joseph Soka, Cynthia D. Fast, Stephen Mwimanzi, Gilbert Mwesiga, Nashon Edward, Marygiven Stephen, Reheme Kondo, Robert Burny, Christophe Cox, Negussie Beyene
African giant pouched rats, trained by Anti-Persoonsmijnen Ontmijnende Product Ontwikkeling (APOPO), have demonstrated their ability to detect tuberculosis (TB) from sputum. We assessed rat-based case detection and compared the mycobacterium bacillary load (MTB-load) in children versus adults. From January–December 2022, samples were collected prospectively from 69 Directly Observed Therapy (DOT) facilities’
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Correction to: Etiologies of fever of unknown origin in HIV/AIDS patients, Hanoi, Vietnam BMC Infect. Dis. (IF 3.7) Pub Date : 2024-04-15 Thu Kim Nguyen, Yen Hai Nguyen, Hao Thi Nguyen, Quang Minh Khong, Ngoc Kim Tran
Correction: BMC Infectious Diseases (2022)22:61 https://doi.org/10.1186/s12879-022-07049-3 After the publication of this article [1], it came to our attention that some of the data presented had been published previously [2]. In this study [2], HIV-infected patients having persistent fever diagnosed of at least one infectious etiology were selected to determine and describe several common opportunistic
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Monocytic myeloid-derived suppressor cells as an immune indicator of early diagnosis and prognosis in patients with sepsis BMC Infect. Dis. (IF 3.7) Pub Date : 2024-04-13 Juanjuan Cui, Wen Cai, Jing Lin, Li Zhang, Youhan Miao, Ying Xu, Weifeng Zhao
Immunosuppression is a leading cause of septic death. Therefore, it is necessary to search for biomarkers that can evaluate the immune status of patients with sepsis. We assessed the diagnostic and prognostic value of low-density neutrophils (LDNs) and myeloid-derived suppressor cells (MDSCs) subsets in the peripheral blood mononuclear cells (PBMCs) of patients with sepsis. LDNs and MDSC subsets were
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Beyond prediction: unveiling the prognostic power of μ-opioid and cannabinoid receptors, alongside immune mediators, in assessing the severity of SARS-CoV-2 infection BMC Infect. Dis. (IF 3.7) Pub Date : 2024-04-12 Masoumeh Tavakoli-Yaraki, Aida Abbasi, Fatemeh Nejat Pishkenari, Saeed Baranipour, Alireza Jahangirifard, Seyed Bashir Mirtajani, Zahra Noorani Mejareh, Mohammad Amin Vaezi, Jila Yavarian, Bahare Abdollahi, Talat Mokhtari-Azad, Vahid Salimi
This study aims to explore the potential of utilizing the expression levels of cannabinoid receptor 2 (CB2), μ-opioid receptor (MOR), MCP-1, IL-17, IFN-γ, and osteopontin as predictors for the severity of SARS-CoV-2 infection. The overarching goal is to delineate the pathogenic mechanisms associated with SARS-CoV-2. Using quantitative Real-time PCR, we analyzed the gene expression levels of CB2 and
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Disseminated Cryptococcus neoformans infection involving multiple bones and lung in an immunocompetent patient: a case report BMC Infect. Dis. (IF 3.7) Pub Date : 2024-04-12 Yang-Ming Lee, Yuag-Meng Liu, Tsung-Chia Chen
Cryptococcal osteomyelitis is a rare and potentially serious condition, typically encountered in individuals with compromised immune systems. This case underscores the unusual occurrence of disseminated Cryptococcosis in an immunocompetent person, involving multiple bones and lungs, with Cryptococcus neoformans identified as the causative agent. An Indonesian man, previously in good health, presented
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Predictors of quality of life of TB/HIV co-infected patients in the Northern region of Ghana BMC Infect. Dis. (IF 3.7) Pub Date : 2024-04-12 Jacob Nignan Nabei, Harriet Affran Bonful, Edwin Andrews Afari, Abdul Gafaru Mohammed, Adote Anum
Tuberculosis (TB) and human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS) co-morbidity continues to be a serious worldwide health issue, particularly in Sub-Saharan Africa. Studies on the quality of life (QOL) of TB/HIV co-infected patients guide stakeholders on the delivery of patient-centred healthcare. This study evaluated QOL of TB/HIV co-infected individuals and its contributing
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Significance of early diagnosis and surgical management in treating Mycobacterium immunogenum-related pyogenic extensor tenosynovitis: a case report BMC Infect. Dis. (IF 3.7) Pub Date : 2024-04-12 Tomohide Okinaka, Kenjiro Fujimura, Yuka Hamasaki, Yuichi Hasegawa, Takashi Matono
Non-tuberculous mycobacteria (NTM) are environmental organisms that are increasingly contributing to human infections. Mycobacterium immunogenum, a variant of NTM discovered in 2001, is a rapidly growing mycobacterium that exhibits multidrug resistance. Reports of infections caused by this organism, particularly tenosynovitis in the musculoskeletal system, are limited. A 71-year-old female with vesicular
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Correction: COVID-19 outbreaks surveillance through text mining applied to electronic health records BMC Infect. Dis. (IF 3.7) Pub Date : 2024-04-11 Hermano Alexandre Lima Rocha, Erik Zarko Macêdo Solha, Vasco Furtado, Francion Linhares Justino, Lucas Arêa Leão Barreto, Ronaldo Guedes da Silva, Ítalo Martins de Oliveira, David Westfall Bates, Luciano Pamplona de Góes Cavalcanti, Antônio Silva Lima Neto, Erneson Alves de Oliveira
Correction: BMC Infect Dis 24, 359 (2024) https://doi.org/10.1186/s12879-024-09250-y Following publication of the original article [1], we have been notified that the Results section of the Abstract was missing the mathematical symbols. Originally published Results: Corrected Results: The original article has been corrected. Rocha, et al. COVID-19 outbreaks surveillance through text mining applied
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Epidemiological investigation of dengue fever outbreak and its socioeconomic determinants in Banadir region, Somalia BMC Infect. Dis. (IF 3.7) Pub Date : 2024-04-11 Mohamed Abdelrahman Mohamed, Nuralein Yusuf Hassan, Marian Muse Osman, Saido Gedi, Bisma Abdullahi Ali Maalin, Kasim Mahdi Sultan, Bashiru Garba, Ali Abdirahman Osman, Abdinasir Yusuf Osman, Abdifatah Diriye Ahmed
Dengue has become an alarming global problem and is endemic in many countries, particularly in tropical and subtropical countries. The aim of this study was to investigate dengue fever outbreak in Banadir Region, Somalia, to understand the risk factors (time, place, personal characteristics). A descriptive cross-sectional study was undertaken to determine the levels of circulating anti-dengue virus
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Risk factors for COVID-19 associated pulmonary aspergillosis and outcomes in patients with acute respiratory failure in a respiratory sub-intensive care unit BMC Infect. Dis. (IF 3.7) Pub Date : 2024-04-11 Alessandra Iacovelli, Alessandra Oliva, Flavio Marco Mirabelli, Silvia Giannone, Marianna Laguardia, Matteo Morviducci, Maria Luisa Nicolardi, Emma Repaci, Maria Teresa Sanzari, Cristiana Leanza, Giammarco Raponi, Claudio Mastroianni, Paolo Palange
COVID-19-associated pulmonary aspergillosis (CAPA) is burdened by high mortality. Data are lacking about non-ICU patients. Aims of this study were to: (i) assess the incidence and prevalence of CAPA in a respiratory sub-intensive care unit, (ii) evaluate its risk factors and (iii) impact on in-hospital mortality. Secondary aims were to: (i) assess factors associated to mortality, and (ii) evaluate
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Willingness to receive COVID-19 vaccines, associated factors and reasons for not taking a vaccine: a cross sectional study among persons aged 13–80 years in Wakiso, Central Uganda BMC Infect. Dis. (IF 3.7) Pub Date : 2024-04-11 Alex Daama, Naziru Rashid, Kasango Asani, Grace Kigozi Nalwoga, Fred Nalugoda, Robert Bulamba, Emmanuel Kyasanku, Gertrude Nakigozi, Godfrey Kigozi, Joseph Kagaayi, Stephen Mugamba
Vaccination has been recommended as one of the approaches for the control of COVID-19 pandemic. However, adequate vaccine coverage is critical to the effectiveness of the vaccine at population level. Data on acceptability of the vaccine in Ugandan urban areas are limited. This study examined the prevalence, factors associated with willingness to accept COVID-19 vaccine including reasons for not taking
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HIV viral suppression and risk of viral rebound in patients on antiretroviral therapy: a two- year retrospective cohort study in Northern Tanzania BMC Infect. Dis. (IF 3.7) Pub Date : 2024-04-11 Monica S Kahabuka, Yimtubezinash Woldeamanuel, Peter M. Mbelele, Emmanuel A. Mpolya, Stellah G. Mpagama, Jonas P. Kessy, Tsegahun Manyazewal
The world is moving towards the third target of the Joint United Nations Programme on HIV/AIDS to ensure most people receiving antiretroviral therapy (ART) are virologically suppressed. Little is known about viral suppression at an undetectable level and the risk of viral rebound phenomenon in sub-Saharan Africa which covers 67% of the global HIV burden.This study aimed to investigate the proportion
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Influence of initial misdiagnosis on mortality in patients with bacteraemia: propensity score matching and propensity score weighting analyses BMC Infect. Dis. (IF 3.7) Pub Date : 2024-04-11 Anna M. Eikenboom, Merel M. C. Lambregts, Mark G. J. de Boer, Saskia le Cessie
The diagnostic process is a key element of medicine but it is complex and prone to errors. Infectious diseases are one of the three categories of diseases in which diagnostic errors can be most harmful to patients. In this study we aimed to estimate the effect of initial misdiagnosis of the source of infection in patients with bacteraemia on 14 day mortality using propensity score methods to adjust
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Pre-COVID-19-pandemic RSV epidemiology and clinical burden in pediatric primary care in Italy: a comparative analysis across two regions for the 2019/2020 season BMC Infect. Dis. (IF 3.7) Pub Date : 2024-04-11 Elisabetta Pandolfi, Daniela Loconsole, Maria Chironna, Jojanneke van Summeren, John Paget, Massimiliano Raponi, Luisa Russo, Ilaria Campagna, Ileana Croci, Carlo Concato, Carlo Federico Perno, Alberto Eugenio Tozzi, Giulia Linardos, Veronica Bartolucci, Sara Ciampini, Andrea Onetti Muda, Luigi De Angelis, Marta Luisa Ciofi Degli Atti, Caterina Rizzo
Respiratory syncytial virus (RSV) infection in children under 5 years have a significant clinical burden, also in primary care settings. This study investigates the epidemiology and burden of RSV in Italian children during the 2019/20 pre-pandemic winter season. A prospective cohort study was conducted in two Italian regions. Children with Acute Respiratory Infection (ARI) visiting pediatricians were
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Correction: Nontuberculous mycobacteria testing and culture positivity in the United States BMC Infect. Dis. (IF 3.7) Pub Date : 2024-04-10 Julia E. Marshall, Rachel A. Mercaldo, Ettie M. Lipner, D. Rebecca Prevots
Correction: BMC Infect Dis 24, 288 (2024) https://doi.org/10.1186/s12879-024-09059-9 Following publication of the original article [1], we have been notified that Figure 3 was incorrect. Originally published Figure 3: Correct Figure 3: The original article has been corrected. Marshall, et al. Nontuberculous mycobacteria testing and culture positivity in the United States. BMC Infect Dis. 2024;24:288
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Impact of the COVID-19 outbreak and interventions on hand, foot and mouth disease in Zhengzhou, China, 2014–2022: a retrospective study BMC Infect. Dis. (IF 3.7) Pub Date : 2024-04-09 Wanyu Jia, Xue Zhang, Ruiyang Sun, Peng Li, Chunlan Song
Since December 2019, COVID-19 has spread rapidly around the world, and studies have shown that measures to prevent COVID-19 can largely reduce the spread of other infectious diseases. This study explored the impact of the COVID-19 outbreak and interventions on the incidence of HFMD. We gathered data on the prevalence of HFMD from the Children’s Hospital Affiliated to Zhengzhou University. An autoregressive
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Factors affecting hand hygiene practice during the COVID-19 pandemic in the Zimbabwean population: a qualitative study BMC Infect. Dis. (IF 3.7) Pub Date : 2024-04-09 Nicholas Midzi, Masceline Jenipher Mutsaka-Makuvaza, Lincoln Sunganai Charimari, Priscilla Mangwiro, Tonderai Manengureni, Gladys Mugadza
Practicing hand hygiene is recommended as one of the key preventive measures for reducing the transmission of COVID-19 and other infectious agents. However, it is often not practiced frequently enough or correctly by the public. We aimed to identify barriers to and facilitators of hand hygiene in the Zimbabwean population during the COVID-19 pandemic. A qualitative study was conducted with a purposive
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Association of haemato-biochemical indices and blood composite ratios with microfilaridermia in Onchocerciasis patients BMC Infect. Dis. (IF 3.7) Pub Date : 2024-04-08 Linda Batsa Debrah, Charles Gyasi, Monica Ahiadorme, Abu Abudu Rahamani, Vera Serwaa Opoku, Prince Obeng, Jubin Osei-Mensah, Michael Agyemang Obeng, Derrick Adu Mensah, Alexander Yaw Debrah
Onchocerciasis causes chronic systemic inflammation. Several studies have used markers such as haemato-biochemical indices to predict the occurrence of systemic inflammation. This study assessed the variability and predictability of haemato-biochemical indices and blood composite ratios (BCRs) in microfilariae positive (MF+) and microfilariae negative (MF-) subgroups of onchocercomata participants
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Clinical outcomes of liver transplantation in human immunodeficiency virus/hepatitis B virus coinfected patients in China BMC Infect. Dis. (IF 3.7) Pub Date : 2024-04-08 Jianxin Tang, Ruihui Weng, Taishi Fang, Kangjun Zhang, Xu Yan, Xin Jin, Linjie Xie, Dong Zhao
Highly active antiretroviral therapy (HAART) has been able to improve the immune system function and survival of human immunodeficiency virus (HIV) patients. However, Patients coinfected with HIV and hepatitis B virus (HBV) are more likely to develop end-stage liver disease (ESLD) than those infected with HBV alone. Consequently, liver transplantation is often required for these patients. This study
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Hemophagocytic lymphohistiocytosis and myopericarditis induced by campylobacter: a case report BMC Infect. Dis. (IF 3.7) Pub Date : 2024-04-08 Chia Hua Chang, Chih-Chuan Kao
Hemophagocytic lymphohistiocytosis (HLH) is a severe disorder characterized by excessive activation of the immune system, leading to hypercytokinemia and damage to multiple organs. We report a rare case of HLH with myopericarditis caused by Campylobacter infection. A 28-year-old male patient with a history of hypertension without medicine control presented at the hospital after a four-day fever, decreasing
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Bacteremia caused by Nocardia farcinica: a case report and literature review BMC Infect. Dis. (IF 3.7) Pub Date : 2024-04-08 Di Wang, Meng-Ting Hu, Wen-Jing Liu, Ying Zhao, Ying-Chun Xu
Nocardia farcinica is one of the most common Nocardia species causing human infections. It is an opportunistic pathogen that often infects people with compromised immune systems. It could invade human body through respiratory tract or skin wounds, cause local infection, and affect other organs via hematogenous dissemination. However, N. farcinica-caused bacteremia is uncommon. In this study, we report