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Machine Learning-based Development and Validation of a Cell Senescence Predictive and Prognostic Signature in Intrahepatic Cholangiocarcinoma J. Cancer (IF 3.9) Pub Date : 2024-3-25 Ruida Yang, Feidi Sun, Yu Shi, Huanhuan Wang, Yangwei Fan, Yinying Wu, Ruihan Fan, Shaobo Wu, Liankang Sun
Background: Previous studies have shown that cellular senescence is strongly associated with tumorigenesis and the tumor microenvironment. Accordingly, we developed a novel prognostic signature for intrahepatic cholangiocarcinoma (ICCA) based on senescence-associated long non-coding RNAs (SR-lncRNAs) and identified a lncRNA-miRNA-mRNA axis involving in ICCA./nMethods: Based on the 197 senescence-associated
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Inverse association between age and risk of lymph node metastasis in patients with early gastric cancer: a surveillance, epidemiology, and end results analysis J. Cancer (IF 3.9) Pub Date : 2024-3-25 Suya Pang, Weijun Wang, Jianning Zhou, Xin Jiang, Rong Lin
Background: Recent studies have shown that young patients with gastric cancer are at a more advanced stage and have poor survival, but the cause is still unclear. The prognosis of gastric cancer is closely related to LNM, but the relationship between age and LNM in early gastric cancer (EGC) is currently unclear. Therefore, we aimed to study the relationship between age and the risk of LNM in EGC./nMaterials
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Safety and Efficacy Analysis of Radical Surgery for 403 Patients with Colon Cancer over 80 Years Old J. Cancer (IF 3.9) Pub Date : 2024-3-25 Ruilong Niu, Mandula Bao, Yujuan Jiang, Jinjie Zhang, Xiaowei Qin, Kangkang Zhang, Jianjun Bi, Wei Xing, Wei Guo, Jianwei Liang
Aim: To investigate the safety and efficacy of radical surgery in colon cancer patients over 80 years old./nMethods: Data from colon cancer patients aged ≥80 years who underwent radical surgery at the Cancer Hospital of the Chinese Academy of Medical Sciences and affiliated Heji Hospital of Changzhi Medical College from January 2011 to December 2022 were retrospectively analysed. Data on clinical characteristics
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Comprehensive analysis of IGF2BP3 with expression features, prognosis, immune modulation and stemness in hepatocellular carcinoma and pan-cancer J. Cancer (IF 3.9) Pub Date : 2024-3-25 Sha Qin, Haoer Jin, Yan Li, Xue Chen, Jiang He, Juxiong Xiao, Yan Qin, Chuyi Liu, Yitao Mao, Luqing Zhao
Insulin like growth factor 2 mRNA binding protein 3 (IGF2BP3) is a critical m6A reader. It encodes proteins that contain several KH domains, which are important in RNA binding, RNA synthesis and metabolism. Lots of researches have studied the malignant potential of m6A readers in tumors. However, the biological functional analysis of IGF2BP3 in hepatocellular carcinoma (HCC) and pan-cancer is not comprehensive
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Construction and multicohort validation of a colon cancer prognostic risk score system based on big data of neutrophil-associated differentially expressed genes J. Cancer (IF 3.9) Pub Date : 2024-3-25 Yunxi Yang, Cheng Lu, Linbin Li, Chunfang Zheng, Yifan Wang, Jiahui Chen, Bingwei Sun
Objective: To investigate the role of neutrophils in colon cancer progression./nMethods: Genetic data from 1,273 patients with colon cancer were procured from public databases and categorized based on genes linked to neutrophils through an unsupervised clustering approach. Through univariate Cox regression analysis, differentially expressed genes (DEGs) influencing overall survival (OS) were identified
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Unraveling the role of the circadian clock genes in cervical squamous cell carcinoma and endocervical adenocarcinoma: A prognostic indicator for prognostic, immunotherapy response, and chemotherapy sensitivity J. Cancer (IF 3.9) Pub Date : 2024-3-19 Jiayu Xu, Xueyuan Huang, Siqi Gou, Huanyu Luo, Shicheng Zeng, Qinhong Zhang, Qibiao Wu, Hao Chi, Guanhu Yang
Background: Cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC) account for a significant proportion of gynecological malignancies and represent a major global health concern. Globally, CESC is ranked as the fourth most common cancer among women. Conventional treatment of this disease has a less favorable prognosis for most patients. However, the discovery of early molecular biomarkers
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Defining the biological functions and clinical significance of AKR1C3 in gastric carcinogenesis through multiomics functional analysis and immune infiltration analysis J. Cancer (IF 3.9) Pub Date : 2024-3-17 Yongfu Shao, Xuan Yu, Keshu Shan, Jianing Yan, Guoliang Ye
Background: Human aldo-keto reductase family 1 member C3 (AKR1C3) is an important molecule that participates in multiple physiological metabolic processes. However, its expression, biological functions and clinical significance in gastric carcinogenesis are unclear./nMethods: We collected data from several public data portals and clinical samples and systematically analyzed the clinical significance
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Copper-binding protein modelling by single-cell transcriptome and Bulk transcriptome to predict overall survival in lung adenocarcinoma patients J. Cancer (IF 3.9) Pub Date : 2024-3-17 Min Shengping, Wang Luyao, Xie Yiluo, Chen Huili, Wang Ruijie, Song Ge, Wang Xiaojing, Lian Chaoqun
Background: Copper and copper-binding proteins are key components of tumour progression as they play an important role in tumour invasion and migration, and abnormal accumulation of copper (Cu) may be intimately linked to with lung adenocarcinoma (LUAD)./nMethods: Data on lung adenocarcinoma were sourced from the Cancer Genome Atlas (TCGA) database and the National Centre for Biotechnology Information
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Identification of Molecular Subtype and Prognostic Signature for Prostate Adenocarcinoma based on Neutrophil Extracellular Traps J. Cancer (IF 3.9) Pub Date : 2024-3-17 Yanfen Zheng, Hui Sun, Shanshan Yang, Wei Liu, Guanmin Jiang
Background: Prostate adenocarcinoma (PRAD) is one of the most common cancers in male. Increasing evidences pointed out that Neutrophil Extracellular Traps (NETs) play an important role in tumor angiogenesis, tumor metastasis and drug resistance. However, limited systematic studies regarding the role of NETs in PRAD have been performed. Identification of biomarkers based on NETs might facilitate risk
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Discovery of a novel ROS-based signature for predicting prognosis and immunosuppressive tumor microenvironment in lung adenocarcinoma J. Cancer (IF 3.9) Pub Date : 2024-3-17 Yufeng Guo, Geyun Chang, Rui Wan, Xue Zhang, Zixiao Ma, Hua Bai, Jie Wang
The role of reactive oxygen species (ROS) is critical in the emergence and progression of lung adenocarcinoma (LUAD), affecting cell survival, proliferation, angiogenesis, and metastasis. Further investigations are needed to elucidate these effects' precise pathways and devise therapeutic approaches targeting ROS. Moreover, the expression pattern and clinical significance of the ROS-related genes in
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ASB6 as an Independent Prognostic Biomarker for Colorectal Cancer Progression Involves Lymphatic Invasion and Immune Infiltration J. Cancer (IF 3.9) Pub Date : 2024-3-17 Qingyong Hu, Yahui Chen, Qianru Zhou, Shanshan Deng, Bo Mu, Jiancai Tang
Background: ASB6, an E3 ubiquitin ligase, mediates the proteasomal degradation of its substrate proteins via the ubiquitin-proteasome pathway. ASB6 has been reported to play significant roles in several biological processes, including tumor stemness and endoplasmic reticulum stress. However, the underlying role and mechanism of ASB6 in colorectal cancer, particularly its association with immune infiltration
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Potential Role of MAP3K14 in Hepatocellular Carcinoma: A Study Based on Comprehensive Bioinformatical Analysis and Validation J. Cancer (IF 3.9) Pub Date : 2024-3-17 Ke Tang, Weiquan Lin, Dedong Wang, Xiangzhi Hu, Zhitao Chen, Jinbin Chen, Boheng Liang, Lin Zhang, Pengzhe Qin, Di Wu
According to reports, MAP3K14 is considered an oncogene and is aberrantly expressed in various types of tumor cells. Its abnormal expression is closely associated with the occurrence and progression of various cancers. MAP3K14 also plays a significant role in the development of non-alcoholic steatohepatitis (NASH)-related hepatocellular carcinoma and its connection to tumor stem cells. The prognostic
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MiR-383-5p inhibits the proliferation and migration of lung adenocarcinoma cells by targeting SHMT2 J. Cancer (IF 3.9) Pub Date : 2024-3-17 Xianxia Bi, Luwei Wang, Hua Li, Ying Ma, Ruoyu Guo, Jicheng Yue, Lijun Kong, Xiangqian Gong, Fei Jiao, Eugene Chinn, Jinxia Hu
Purpose: To explore the effects of miR-383-5p and serine hydroxymethyltransferase 2 (SHMT2) on the proliferation and migration of lung adenocarcinoma cells./nMethods: SHMT2 expression in lung adenocarcinoma and normal tissues was investigated using The Cancer Genome Atlas database. Immunohistochemical analysis was performed to confirm SHMT2 expression in lung adenocarcinoma and adjacent normal lung
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Glucose metabolism reprogramming in gynecologic malignant tumors J. Cancer (IF 3.9) Pub Date : 2024-3-17 Jianhong Ma, Zhiqiang Yao, Liangjian Ma, Qinyin Zhu, Jiajia Zhang, Ling Li, Chang Liu
The incidence and mortality of gynecological tumors are progressively increasing due to factors such as obesity, viral infection, unhealthy habits, as well as social and economic pressures. Consequently, it has emerged as a significant threat to women's health. Numerous studies have revealed the remarkable metabolic activity of tumor cells in glycolysis and its ability to influence malignant biological
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The Roles of CircRNAs in Mitochondria J. Cancer (IF 3.9) Pub Date : 2024-3-17 Donghong Liu, Xinyu Zhou, Yida He, Jun Zhao
Mitochondria participate in varieties of cellular events. It is widely accepted that human mitochondrial genome encodes 13 proteins, 2 rRNAs, and 22 tRNAs. Gene variation derived from human nuclear genome cannot completely explain mitochondrial diseases. The advent of high-throughput sequencing coupled with novel bioinformatic analyses decode the complexity of mitochondria-derived transcripts. Recently
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PD-1/PD-L1 Inhibitor - Related Adverse Events and Their Management in Breast Cancer J. Cancer (IF 3.9) Pub Date : 2024-3-17 Chuqi Lei, Xiangyi Kong, Yuan Li, Huaiyu Yang, Ke Zhang, Zhongzhao Wang, Hu Chang, Lixue Xuan
As the positive results of multiple clinical trials were released, the Programmed cell death 1 (PD-1) and Programmed cell death ligand 1 (PD-L1) inhibitors emerge as the focus of integrative breast cancer treatment. PD-1/PD-L1 inhibitors are often used as a sequential agent to be combined with other agents such as chemotherapeutic agents, targeted agents, and radiation therapy. As multiple therapies
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Nudifloside, a Secoiridoid Glucoside Derived from Callicarpa nudiflora, Inhibits Endothelial-to-Mesenchymal Transition and Angiogenesis in Endothelial Cells by Suppressing Ezrin Phosphorylation J. Cancer (IF 3.9) Pub Date : 2024-3-11 Dongliang Zhuo, Yinlong Mei, Chaozhan Lin, Aizhi Wu, Yuehua Luo, Hong Lu, Jianjiang Fu
Callicarpa nudiflora is a traditional folk medicine in China used for eliminating stasis to subdue swelling. Several compounds from Callicarpa nudiflora have been proved to show anti-inflammatory, haemostasis, hepatitis, and anti-proliferative effects. Tumor endothelial cells play crucial roles in tumor-induced angiogenesis. Recently, it was demonstrated that ECs may be the important source of cancer
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NEDD1 overexpression increases cell proliferation, tumor immune escape, and drug resistance in LUAD J. Cancer (IF 3.9) Pub Date : 2024-3-11 Ting Zhuo, Zuotao Wu, Sirong Chen, Chuyi Yang, Hongyu Huang, Jinyan Gan, Jueqi Lyu, Juan Xiao, Zihao Li, Shouming Qin, Yanbin Wu
Background: Neural Precursor Cell Expressed Developmentally Down-Regulated Protein 1 (NEDD1) serves as a crucial factor in promoting cellular mitosis by directly facilitating wheel assembly and daughter centriole biogenesis at the lateral site of parent centrioles, ultimately driving centrosome replication. The amplification of centrosomes and the abnormal expression of centrosome-associated proteins
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KYNU Expression Promotes Cisplatin Resistance in Esophageal Cancer J. Cancer (IF 3.9) Pub Date : 2024-3-11 Yu Lu, Xianyang Zhao, Mingliang Yuan, Ming Zhao, Kaisheng Liu, Miaomiao Zhang, Xiaoyan Qiu, Xuechun Yu, Xinliang Liu, Dongping Wei, Jun Xie, Zhongbin Cheng
Background: Chemotherapy resistance is a barrier to effective cancer prognoses. Cisplatin (CDDP) resistance is a major challenge for esophageal cancer (EC) therapy. A deeper understanding of the fundamental mechanisms of cisplatin resistance and improved targeting strategies are required in clinical settings. This study was performed to identify and characterize a marker of cisplatin resistance in
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Identification of PANoptosis-related predictors for prognosis and tumor microenvironment by multiomics analysis in glioma J. Cancer (IF 3.9) Pub Date : 2024-3-11 Fengzeng Sun, Miaomiao Liao, Zi Tao, Ruiqi Hu, Jun Qin, Weiwei Tao, Wentong Liu, Yiqi Wang, Guoliang Pi, Junrong Lei, Wendai Bao, Zhiqiang Dong
PANoptosis is a newly described inflammatory programmed cell death, that highlights coordination between pyroptosis, apoptosis and necroptosis. However, the functions of PANoptosis-related genes in glioma progression still remain to be explored. This study aims to identify PANoptosis-related predictors that may be utilized for prognosis prediction and development of new therapeutic targets. Firstly
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B7-H3 suppresses CD8+ T cell immunologic function through reprogramming glycolytic metabolism J. Cancer (IF 3.9) Pub Date : 2024-3-11 Yulu Wu, Wenzhe Han, Xiufa Tang, Jiyuan Liu, Zhiyong Guo, Zhangao Li, Chenchen Cai, Lin Que
Malignant neoplasms pose a formidable threat to human well-being. Prior studies have documented the extensive expression of B7 homolog 3 (B7-H3 or CD276) across various tumors, affecting glucose metabolism. Yet, the link between metabolic modulation and immune responses remains largely unexplored. Our study reveals a significant association between B7-H3 expression and advanced tumor stages, lymph
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circular RNA circ-231 promotes protein biogenesis of TPI1 and PRDX6 through mediating the interaction of eIF4A3 with STAU1 to facilitate unwinding of secondary structure in 5′ UTR, enhancing progression of human esophageal squamous cell carcinoma (ESCC) J. Cancer (IF 3.9) Pub Date : 2024-3-11 Guo-Wei Huang, Ti-Qun Yang, Qian-Qian Chen, Xing-Mu Liu, Ling-Hui Xie, Wei Huang, Xue-Ling Chen, Yi-Qun Geng, Jiang Gu
Background: The nuclear cap-binding complex (CBC)-dependent translation (CT) is an important initial translation pathway for 5′-cap-dependent translation in normal mammal cells. Eukaryotic translation initiation factor 4A-III (eIF4A3), as an RNA helicase, is recruited to CT complex and enhances CT efficiency through participating in unwinding of secondary structure in the 5′ UTR. However, the detailed
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PHGDH is Key to a Prognostic Multigene Signature and a Potential Therapeutic Target in Acute Myeloid Leukemia J. Cancer (IF 3.9) Pub Date : 2024-3-11 Jiagui Zhong, Kezhi Huang, Shaofan Xie, Ailian Tan, Jiaqin Peng, Danian Nie, Liping Ma, Yiqing Li
As a rate-limiting enzyme for the serine biosynthesis pathway (SSP) in the initial step, phosphoglycerate dehydrogenase (PHGDH) is overexpressed in many different tumors, and pharmacological or genetic inhibition of PHGDH promotes antitumor effects. In the present research, by analyzing several acute myeloid leukemia (AML) datasets in the Gene Expression Omnibus (GEO), we identified prognosis-related
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Ribosomal protein L22 like 1: a promising biomarker for lung adenocarcinoma J. Cancer (IF 3.9) Pub Date : 2024-3-11 Yahua Wu, Na Yao, Bin Du, Yingjiao Zhu, Xiaohui Ji, Chengliu Lv, Jinhuo Lai
No studies have reported the effect of ribosomal protein L22 like 1 (RPL22L1) in lung adenocarcinoma (LUAD). Therefore, we aimed to systematically investigate the role of RPL22L1 in LUAD. The expression of RPL22L1 was analyzed using TCGA, GEO, TIMER, UALCAN databases, and validated by immunohistochemistry (IHC). Gene methylation analysis was performed using the UALCAN, GSCA and MethSurv databases.
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USP15 promotes the progression of papillary thyroid cancer by regulating HMGB1 stability through its deubiquitination J. Cancer (IF 3.9) Pub Date : 2024-3-11 Si-si Wang, Dao-xiong Ye, Bo Wang, Meng-yao Li, Wen-xin Zhao
Purpose: Papillary thyroid cancer (PTC) stands as one of the most prevalent types of thyroid cancers, characterized by a propensity for in-situ recurrence and distant metastasis. The high mobility group protein (HMGB1), a conserved nuclear protein, plays a pivotal role in carcinogenesis by stimulating tumor cell growth and migration. Nevertheless, the underlying mechanism driving aberrant HMGB1 expression
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Prognostic significance of BRCA1 and BRCA2 methylation status in circulating cell-free DNA of Pancreatic Cancer patients J. Cancer (IF 3.9) Pub Date : 2024-3-11 Triantafyllia Koukaki, Ioanna Balgkouranidou, Eirini Biziota, Anastasios Karayiannakis, Helen Bolanaki, Evangelos Karamitrousis, Paul Zarogoulidis, Savas Deftereos, Charalampos Charalampidis, Aris Ioannidis, Dimitrios Matthaios, Kyriakos Amarantidis, Stylianos Kakolyris
Introduction: Pancreatic cancer is the most fatal cancer type in the world. Its high mortality is mostly correlated to the absence of symptoms and the difficulty in early diagnosis, which in the majority of the cases occurs when the disease has already spread metastasis. Nowadays, tests that could predict early diagnosis are not available yet and the number of prognostic tests is limited. Hence, there
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Prognostic and Immune Landscape Analysis of Ubiquitination-related Genes in Hepatocellular Carcinoma: Based on Bulk and Single-cell RNA Sequencing Data J. Cancer (IF 3.9) Pub Date : 2024-3-11 Zibo Yuan, Qingwei Zhu, Qingsong Wu, Zhe Zhang, Junwei Guo, Gongqiang Wu, Cuiping Zheng, Qiuran Xu, Dongsheng Huang, Di Cui
Background: Despite significant advances in tumor immunotherapy, hepatocellular carcinoma (HCC) remains a malignancy with a challenging prognosis. The increasing research emphasizes the crucial role of ubiquitination in tumor immunotherapy. However, the establishment of prognostic signatures based on ubiquitination-related genes (UbRGs) and their role in immunotherapy are still lacking in HCC./nMethods:
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ARID1B Deficiency Leads to Impaired DNA Damage Response and Activated cGAS-STING Pathway in Non-Small Cell Lung Cancer J. Cancer (IF 3.9) Pub Date : 2024-3-11 Guangsheng Zhu, Jinghao Liu, Yongwen Li, Hua Huang, Chen Chen, Di Wu, Peijun Cao, Lianchun Su, Yanan Wang, Hongbing Zhang, Hongyu Liu, Jun Chen
Purpose: Lung cancer is a major cause of morbidity and mortality globally, necessitating the identification of predictive markers for effective immunotherapy. Mutations in SWI/SNF chromatin remodeling complex genes were reported sensitized human tumors to immune checkpoint inhibitors (ICIs), but the underlying mechanisms are unclear. This study aims to investigate the association between SWI/SNF gene
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tsRNA: A Promising Biomarker in Breast Cancer J. Cancer (IF 3.9) Pub Date : 2024-3-11 Ting Huang, Yuexin Zhao, Guoqin Jiang, Zhixue Yang
tRNA-derived small RNAs (tsRNAs) are a novel class of non-coding small RNAs, generated from specific cleavage sites of tRNA or pre-tRNA. tsRNAs can directly participate in RNA silencing, transcription, translation, and other processes. Their dysregulation is closely related to the occurrence and development of various cancers. Breast cancer is one of the most common and fastest-growing malignant tumors
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Lasiokaurin Regulates PLK1 to Induce Breast Cancer Cell G2/M Phase Block and Apoptosis J. Cancer (IF 3.9) Pub Date : 2024-3-4 Zhengrui Liu, Jia Wang, Siman Xie, Benteng Zhang, Yan Yuan, Huaizi Fu, Hongyun Hao, Li Sun, Shengtao Yuan, Jian Ding, Hong Yu, Mei Yang
Aim of the study: To investigate the anti-tumor effects of Lasiokaurin on breast cancer and explore its underlying molecular mechanism./nMaterials and methods: In this study, MTT assay, plate colony formation assays, soft agar assay, and EdU assay were employed to evaluate the anti-proliferation effects of LAS. Apoptosis and cell cycle distribution were detected by flow cytometry. The molecular mechanism
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c-Rel is a Novel Oncogene in Lung Squamous Cell Carcinoma Regulating Cell Proliferation and Migration J. Cancer (IF 3.9) Pub Date : 2024-3-4 Renru Luo, Qiongyu Liu, Zheyu Hu, Wanqin Dai, Shuwei Huang, Jianjiang Xie, Shuquan Wei, Chuwen Lin
Lung squamous cell carcinoma (LUSC) accounts for approximately 25% to 30% of lung cancers, but largely no targeted therapy is available against it, calling for identification of new oncogenes in LUSC growth for new therapeutic targets. In this study, REL was identified through a screening for oncogenes that are highly amplified in human LUSC. Its expression was associated with poor prognosis in LUSC
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Unveiling the STAT3-ACC1 axis: a key driver of lipid metabolism and tumor progression in non-small cell lung cancer J. Cancer (IF 3.9) Pub Date : 2024-3-4 Hong Zhai, Tiansheng Zheng, Lihong Fan
Background and Objective: Lung cancer is a prevalent global malignancy, and investigating the metabolic reprogramming of tumor cells has significant therapeutic implications. This study aims to explore the molecular mechanism driving the progression of non-small cell lung cancer (NSCLC), with a specific emphasis on the STAT3-ACC1-FAS axis involved in fatty acid synthesis./nMethods: The levels of Signal
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Impact of LINC00312 gene polymorphism coupled with habitual risks on buccal mucosa cancer J. Cancer (IF 3.9) Pub Date : 2024-3-4 Hui-Ting Hsu, Yen-Ting Lu, Yi-Tzu Chen, Ming-Tai Hsing, Chun-Wen Su, Shih-Chi Su, Chiao-Wen Lin, Shun-Fa Yang
Oral squamous cell carcinoma (OSCC) is a prevalent and lethal malignancy with a diverse etiology. LINC00312 is a long intergenic non-coding RNA that functions as a signal hub to regulate the progression and treatment of head and neck cancer. The aim of this study was to evaluate the effect of LINC00312 single nucleotide polymorphisms (SNPs) on the development of oral cancer. Two LINC00312 SNPs, namely
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Evodiamine Inhibits Colorectal Cancer Growth via RTKs Mediated PI3K/AKT/p53 Signaling Pathway J. Cancer (IF 3.9) Pub Date : 2024-3-4 Qiao Zheng, Shengnan Jing, Lin Hu, Xiangrui Meng
Objective: To investigate the inhibitory effect of EVO on colorectal cancer (CRC) growth and further explore the potential mechanism involving the RTKs-mediated PI3K/AKT/p53 signaling pathway./nMethods: Firstly, the inhibitory effect of EVO on CRC cells was detected in vitro by cell viability assay and colony formation assay. The effects of EVO on spatial migration and invasion capacity of cells were
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CMTM6: A Critical Prognostic Indicator in Non-Small Cell Lung Cancer J. Cancer (IF 3.9) Pub Date : 2024-3-4 Fang Dai, Yu-lian Duan, Qiang Feng, Shu-Ling Song, Ju-Lun Yang, Tao Lv
While CKLF-like MARVEL transmembrane domain containing 6 (CMTM6)'s role in stabilizing PD-L1 and immune evasion within tumors is established, its expression in lung cancer tissue and adjacent macrophages remains uncertain. The study aimed to elucidate this ambiguity by investigating CMTM6's role in non-small cell lung cancer (NSCLC) prognosis. Employing immunohistochemical staining on 141 NSCLC and
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Erianin promotes apoptosis and inhibits Akt-mediated aerobic glycolysis of cancer cells J. Cancer (IF 3.9) Pub Date : 2024-3-4 Shuangze Han, Sijin Chen, Jidong Wang, Sheng Huang, Yeqing Xiao, Gaoyan Deng
Highly activated aerobic glycolysis provides the metabolic requirements for tumor cell growth and proliferation. Erianin, a natural product isolated from Dendrobium chrysotoxum Lindl, has been reported to exert antitumor activity in multiple cancers. However, whether Erianin exerts inhibitory effects on aerobic glycolysis and the inherent mechanism remain poorly defined in non-small cell lung cancer
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Systematic Analysis to Identify the MIR99AHG-has-miR-21-5p-EHD1 CeRNA Regulatory Network as Potential Biomarkers in Lung Cancer J. Cancer (IF 3.9) Pub Date : 2024-3-4 Mengju He, Hui Zhang, Yanfei Zhang, Yicen Ding, Fei Zhang, Yani Kang
Lung cancer (LC) remains an extremely lethal disease worldwide, and effective prognostic biomarkers are at top priority. With the rapid development of high-throughput sequencing and bioinformatic analysis methods, the quest to characterize cancer transcriptomes continues to move forward. However, the integrated systematic analysis of lncRNA-miRNA-mRNA regulatory network in LC is lacking. In this study
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Role of Epstein-Barr Virus in Breast Cancer: Correlation with Clinical Outcome and Survival Analysis J. Cancer (IF 3.9) Pub Date : 2024-3-4 Yi-Chiung Hsu, Ming-Han Tsai, Guani Wu, Chien-Liang Liu, Yuan-Ching Chang, Hung-Bun Lam, Pei- Yu Su, Chun-Fan Lung, Po-Sheng Yang
Background: Breast cancer is the most prevalent cancer among women worldwide. The potential involvement of Epstein-Barr virus (EBV) in breast cancer pathogenesis has been a subject of debate, but its correlation with clinical outcomes remains uncertain./nMethods: In this study, we collected 276 pathologically confirmed breast cancer tissue samples from the tissue bank of MacKay Memorial Hospital and
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Illuminating Shared Genetic Associations Between Oesophageal Carcinoma and Pulmonary Carcinoma Risk J. Cancer (IF 3.9) Pub Date : 2024-3-4 Dengfeng Zhang, Jing Li, Tianxing Lu, Fangchao Zhao, Pengfei Guo, Zhirong Li, Xiaoliang Duan, Yishuai Li, Shujun Li, Jianhang Li
Background: Lung cancer and oesophageal cancer are prevalent malignancies with rising incidence and mortality worldwide. While some environmental and behavioural risk factors for these cancers are established, the contribution of genetic factors to their pathogenesis remains incompletely defined. This study aimed to interrogate the intricate genetic relationship between lung cancer and oesophageal
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CFL1 is Implicated in Chronic Myeloid Leukemia Response during Imatinib Therapy J. Cancer (IF 3.9) Pub Date : 2024-3-4 Xiufeng Yin, Xia Li, Hao Jiang, Xiangjie Lin, Zhixin Ma, Xiaochang Chen, Qibei Teng, Jin Zhang, Jie Jin
Cofilin (CFL1) is one critical member of the actin deploy family (ADF). Overexpression of CFL1 is associated with aggressive features and poor prognosis in malignancies. We evaluated the expression of CFL1 in patients with chronic myeloid leukemia in the chronic phase (CML-CP), acute myelocytic leukemia (AML) and healthy controls. The role of CFL1 in imatinib therapy was also investigated using cell
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Uncovering Microbial Composition of the Tissue Microenvironment in Bladder Cancer using RNA Sequencing Data J. Cancer (IF 3.9) Pub Date : 2024-3-4 Ruiqian Yao, Bin Ai, Zeyi Wang, Bing Shen, Geng Xue, Dong Yu
Purpose: Bladder cancer (BC) is one of the top 10 common tumors in the world. It has been reported that microbiota can colonize tissues and play important roles in tumorigenesis and progression. However, the current understanding of microorganisms in the BC tissue microenvironment remains unclear./nMethods: In this study, we integrated the RNA-seq data of 479 BC tissue samples from seven datasets combined
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A Retrospective Analysis of Azvudine in Patients with COVID-19 and Pre-existing Cancer J. Cancer (IF 3.9) Pub Date : 2024-3-4 Fangyu Li, Keao Zheng, Xueyan Qi, Kaixia Cui, Jing Yang, Zhiying Hao
Objectives: Azvudine has been recommended as a potential treatment for the recently discovered Coronavirus disease (COVID-19) in 2019. However, the effectiveness of Azvudine in individuals who have both COVID-19 and pre-existing cancer remains uncertain. Consequently, we undertook a retrospective analysis to evaluate the clinical efficacy of Azvudine therapy in hospitalized patients with COVID-19 and
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Enhancement of Tumorigenicity, Spheroid Niche, and Drug Resistance of Pancreatic Cancer Cells in Three-Dimensional Culture System J. Cancer (IF 3.9) Pub Date : 2024-3-2 Hao-Chien Hung, Tsui-Lien Mao, Ming-Huei Fan, Guan-Zhi Huang, Ainani Priza Minhalina, Chi-Long Chen, Chao-Lien Liu
The three-dimensional (3D) cell culture technique has been applied comprehensively as a variable platform for medical research, biochemical signal pathway analysis, and evaluation of anti-tumor treatment response due to an excellent recapitulation of a tumor microenvironment (TME) in the in vitro cultured cancer cells. Pancreatic cancer (PaC) is one of the toughest malignancies with a complex TME and
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MiR-15b-3p weakens bicalutamide sensitivity in prostate cancer via targeting KLF2 to suppress ferroptosis J. Cancer (IF 3.9) Pub Date : 2024-3-2 Chunlin Zhang, Haitao Yu, Xuesong Bai, Xiang Zhou, Zhenwei Feng, Yang Li, Xiang Peng, Yuhua Mei, Li Li, Xin Gou, Yuanzhong Deng, Guo Chen
Bicalutamide (BIC) resistance impedes the treatment of prostate cancer (PCa) and seems to involve ferroptosis; however, the underlying mechanism remains unclear. Our study aimed to explore how miR-15b-3p modulates ferroptosis in response to BIC resistance and determine whether the miRNA is suitable for early screening of PCa. Here, we found that PCa tissues had significantly higher miR-15b-3p expression
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Identification of T-cell exhaustion-related genes and prediction of their immunotherapeutic role in lung adenocarcinoma J. Cancer (IF 3.9) Pub Date : 2024-2-25 Chaoqun Lian, Feifan Li, Yiluo Xie, Linxiang Zhang, Huili Chen, Ziqiang Wang, Xinyu Pan, Xiaojing Wang, Jing Zhang
Background: Lung adenocarcinoma ranks as the second most widespread form of cancer globally, accompanied by a significant mortality rate. Several studies have shown that T cell exhaustion is associated with immunotherapy of tumours. Consequently, it is essential to comprehend the possible impact of T cell exhaustion on the tumor microenvironment. The purpose of this research was to create a TEX-based
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Prognostic Significance of KIF-12 Functioning as a Tumour Suppressor in Papillary Thyroid Carcinoma J. Cancer (IF 3.9) Pub Date : 2024-2-25 Luying Gao, Ruifeng Liu, Yu Xia, Aonan Pan, Xinlong Shi, Liyuan Ma, Jiang Ji, Ya Hu, Xiaoyi Li, Yuang An, Nengwen Luo, Zhiyong Liang, Liangrui Zhou, Yuxin Jiang
Objective: To explore the potential value of a novel marker, KIF-12, in the progression and prognosis of papillary thyroid carcinoma (PTC) through integrative bioinformatics analysis, and clinical sample validation of the prognostic value of KIF-12./nMaterials and Methods: We extracted the clinicopathological data of 502 PTC patients from The Cancer Genome Atlas-Thyroid Cancer (TCGA-THCA) dataset to
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KRT80 Promotes Lung Adenocarcinoma Progression and Serves as a Substrate for VCP J. Cancer (IF 3.9) Pub Date : 2024-2-25 Shanhua Huang, Weilai Tong, Bowen Yang, Li Ma, Jiaming Zhang, Chunliang Wang, Linlin Xu, Jinhong Mei
Background: Keratin 80(KRT80) encodes a type II intermediate filament protein, known for maintaining cell integrity of cells and its involvement in the tumorigenesis and progression of various cancers. However, comprehensive research on its relevance to lung adenocarcinoma remains limited./nMethods: In this study, we utilized multiple databases to investigate the transcriptional expression of KRT80
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Carbon ion irradiation combined with PD-1 inhibitor trigger abscopal effect in Lewis lung cancer via a threshold dose J. Cancer (IF 3.9) Pub Date : 2024-2-25 Ruifeng Liu, Yichao Geng, Hongtao Luo, Qiuning Zhang, Zhen Yang, Shan Li, Shilong Sun, Zhiqiang Liu, Meng Dong, Tianqi Du, Tuanjie Che, Xiaohu Wang
Background and goal: Carbon ion beam is radio-biologically more efficient than photons and is beneficial for treating radio-resistant tumors. Several animal experiments with tumor-bearing suggest that carbon ion beam irradiation in combination with immunotherapy yields better results, especially in controlling distant metastases. This implies that carbon ion induces a different anti-tumor immune response
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Development and Validation of the novel Cuproptosis- and Immune-related Signature for Predicting Prognosis in Hepatocellular Carcinoma J. Cancer (IF 3.9) Pub Date : 2024-2-25 Yongping Zhang, Ping Sui, Cheng Zhong, Jiansheng Liu
Background: Hepatocellular carcinoma often results in late-stage diagnosis, leading to decreased treatment success. To improve prognosis, this study integrates cuproptosis with immune risk scoring models for HCC patients./nMethod: We identified differentially expressed genes connected to cuproptosis and immune responses using Pearson correlation. A risk signature was then constructed via LASSO regression
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DOT1L promotes expression of CD44 through the Wnt/β-catenin signaling pathway in early gastric carcinoma J. Cancer (IF 3.9) Pub Date : 2024-2-25 Ping Li, Zhou Zhang, Ping Sun
To assess telomere silencing 1-like (DOTIL) gene expression within gastric cancer (GC) tissues as well as its function of promoting cancer stem cell (CSC)-mediated epithelial-mesenchymal switching, tissue samples from 8 patients each in 3 stages (normal, low-grade intraepithelial neoplasia (LGIN), as well as early gastric carcinoma (EGC)) were collected for whole-exome sequencing, which revealed differentially
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LINC00839 in Human Disorders: Insights into its Regulatory Roles and Clinical Impact, with a Special Focus on Cancer J. Cancer (IF 3.9) Pub Date : 2024-2-25 Yingqiu Hu, Yushan Hu, Xuan Lu, Hongliang Luo, Ziwen Chen
LINC00839 has captured significant attention within a spectrum of human disorders, including acute lung injury, osteoarthritis, and childhood obesity. Notably, aberrant expression patterns of LINC00839 have been observed across diverse cancer tissues and cell lines. LINC00839 emerges as an oncogenic factor in tumorigenesis and exerts a positive influence on tumor-associated behaviors. Its therapeutic
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Threatment Strategies for Recurrent Hepatocellular Carcinoma Patients: Ablation and its Combination Patterns J. Cancer (IF 3.9) Pub Date : 2024-2-25 Ya'ning Zhao, Jun Bai, Xi Wang, Yaoren Zhang, Xiaohong Yan, Jun'an Qi, Xueyan Xia, Yuansong Feng, Baojun Duan
With the development of guidance technology and ablation equipment, ablative procedures have emerged as important loco-regional alternatives to surgical resection for recurrent hepatocellular carcinoma (rHCC) patients. Currently, ablation modalities used in clinical practice mainly include radiofrequency ablation (RFA), microwave ablation (MWA), laser ablation (LA), cryoablation (CRA), high-intensity
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Advances in Drug Therapy for Metastatic Pancreatic Ductal Adenocarcinoma J. Cancer (IF 3.9) Pub Date : 2024-2-25 Jianjun Gao, Jiangang Wang, Canghai Guan, Wujiang Shi, Qingfu Dong, Jialin Sheng, Xinlei Zou, Zhaoqiang Xu, Yifei Ge, Ziyue Huang, Jiehan Li, Haolin Bao, Yi Xu, Yunfu Cui, Xiaoxue Xu, Xiangyu Zhong
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive disease with a notably poor prognosis. A large number of patients with PDAC develop metastases before they are diagnosed with metastatic pancreatic cancer (mPDAC). For mPDAC, FOLFIRINOX or gemcitabine plus nab-paclitaxel are the current first-line treatments. It is important to note, however, that many patients will fail chemotherapy because
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CHRNA9 as a New Prognostic Marker and Potential Therapeutic Target in Glioma J. Cancer (IF 3.9) Pub Date : 2024-2-24 Xiaoshan Ma, Ren Geng, Yao Zhao, Wanzhen Xu, Yao Li, Yining Jiang, Yuanhao Liu, Liyan Zhao, Yunqian Li
Background: The nicotinic acetylcholine receptor (nAChR) subunit alpha-9 (CHRNA9) is a unique cholinergic receptor, which is involved in tumor proliferation, apoptosis, metastasis and chemotherapy resistance. However, the correlation between the expression level of CHRNA9 in glioma and the clinical features and prognosis of glioma patients has not been clarified. The aim of this study was to verify
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DHEA down-regulates mitochondrial dynamics and promotes apoptosis of lung adenocarcinoma cells through FASTKD2 J. Cancer (IF 3.9) Pub Date : 2024-2-24 Yan-Fei Zhang, Liu-Liu Yuan, Zong-Can Wang, Wen-Bin Zhuang, Wen-Jia Zhang, Hai-Tao Liu, Ming Li, Li-Hong Fan
Background: DHEA is a steroid hormone produced by the gonads, adrenal cortex, brain, and gastrointestinal tract. While the anti-obesity, anti-atherosclerosis, anti-cancer, and memory-enhancing effects of DHEA have been substantiated through cell experiments, animal studies, and human trials, the precise mechanisms underlying these effects remain unclear. Altered mitochondrial dynamics can lead to mitochondrial
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CBX2 Deletion Suppresses Growth and Metastasis of Colorectal Cancer by Mettl3-p38/ERK MAPK Signalling Pathway J. Cancer (IF 3.9) Pub Date : 2024-2-24 Rui Sun, Xucan Tu, Shixin Chan, Xu Wang, Yizhong Ji, Zhenglin Wang, Zhen Yu, Xiaomin Zuo, Qing Zhang, Jiajie Chen, Qijun Han, Ming Wang, Hu Zhao, Huabing Zhang, Wei Chen
Colorectal cancer (CRC) seriously endangers human health owing to its high morbidity and mortality. Previous studies have suggested that high expression of CBX2 may be associated with poor prognosis in CRC patients. However, its functional role in CRC remains to be elucidated. Herein, we found that CBX2 overexpression in colorectal cancer tissue compared with adjacent tissues. Additionally, forest
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Targeted regulation of miR-154-5p/Cullin2 pathway by hsa_circ_TRIM22 in promoting human papillomavirus 16 positive cervical cancer progression J. Cancer (IF 3.9) Pub Date : 2024-2-24 Weihong Zhao, Songquan Wen, Xiuting Wang, Jingfang Wang, Lili Zhang, Tong Wang
Background. Tripartite motif-containing 22 (TRIM22) is characterized by a canonical RING domain with ubiquitin E3 ligase activity and is closely associated with tumorigenesis. As a product of TRIM22 transcription, whether hsa_circ_TRIM22 has a function of regulating tumorigenesis is unclear. Thus, we aimed to explore the role and mechanism of hsa_circ_TRIM22 in human papillomavirus (HPV) 16 positive
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The Analysis of ceRNA Networks and Tumor Microenvironment in Endometrial Cancer J. Cancer (IF 3.9) Pub Date : 2024-2-24 Jian Huang, Xiaoyue Yang, Shen Xu, Ping Li
Background: Endometrial carcinoma is a life-threatening and aggressive tumor that affects women worldwide. ceRNAs and carcinoma-infiltrating immunocytes can be associated with tumor formation and progression. Therefore, investigating the unique mechanisms underlying endometrial carcinoma is crucial./nMethods: Prognostic nomograms were constructed based on the differentially expressed genes between
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Clinical and laboratory features of different types of cancer-associated thrombosis. J. Cancer (IF 3.9) Pub Date : 2023-10-30 Yanhong Liu,Rufei Ma,Yue Li,Lan Gao
Background: Patients with cancer showed a high incidence of venous thromboembolism (VTE) with a poor prognosis. The risk factors for VTE in different types of cancers may differ. Methods: The clinical features and laboratory test results of cancer patients with VTE in Henan Provincial People's Hospital from 2014 to 2020 were evaluated and compared. Results: Among the eligible patients, gastrointestinal
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PLEKHG2 Promotes NSCLC Cell Growth by Increasing Glycolysis via Activated PI3K/AKT Pathway. J. Cancer (IF 3.9) Pub Date : 2023-10-30 Yang Xia,Xinyu Feng,Yunye Ning,Wei Zhang,Zhenli Hu,Qianqian Chen,Jun Wang,Hao Qin,Yang Lu,Yuchao Dong
Purpose: PLEKHG2 is a member of the diffuse B-cell lymphoma family. The function of PLEKHG2 in NSCLC was still unclear. This study aimed to investigate the relationship between the upregulated expression of PLEKHG2 and the prognosis of NSCLC and to revealed its mechanisms. Materials and methods: The expression of PLEKHG2 in NSCLC patients and its relationship with prognosis were first determined by