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Analysis of differential metabolites in serum metabolomics of patients with aortic dissection BMC Cardiovasc. Disord. (IF 2.1) Pub Date : 2024-04-25 Yun Gong, Tangzhiming Li, Qiyun Liu, Xiaoyu Wang, Zixian Deng, Lixin Cheng, Biao Yu, Huadong Liu
Pathogenesis and diagnostic biomarkers of aortic dissection (AD) can be categorized through the analysis of differential metabolites in serum. Analysis of differential metabolites in serum provides new methods for exploring the early diagnosis and treatment of aortic dissection. This study examined affected metabolic pathways to assess the diagnostic value of metabolomics biomarkers in clients with
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Effects on physical activity, physical fitness and well-being in a 36-months randomized controlled study, comparing a multimodal hospital-based intervention programme for primary cardiovascular prevention with usual care BMC Cardiovasc. Disord. (IF 2.1) Pub Date : 2024-04-25 Hilde Bergum, Jostein Grimsmo, Sigmund Alfred Anderssen, Tor Ole Klemsdal
Cardiovascular disease is a major cause of mortality and morbidity worldwide, and primary prevention efforts are poorly developed in people at high cardiovascular risk. On this background, we performed the Hjerteløftet Study and demonstrated that participation over 36 months in a multimodal primary prevention programme, significantly reduced validated cardiovascular risk scores. In the current substudy
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Association of uncertain significance genetic variants with myocardial mechanics and morphometrics in patients with nonischemic dilated cardiomyopathy BMC Cardiovasc. Disord. (IF 2.1) Pub Date : 2024-04-25 Karolina Mėlinytė-Ankudavičė, Marius Šukys, Gabrielė Kasputytė, Ričardas Krikštolaitis, Eglė Ereminienė, Grytė Galnaitienė, Vaida Mizarienė, Gintarė Šakalytė, Tomas Krilavičius, Renaldas Jurkevičius
Careful interpretation of the relation between phenotype changes of the heart and gene variants detected in dilated cardiomyopathy (DCM) is important for patient care and monitoring. We sought to assess the association between cardiac-related genes and whole-heart myocardial mechanics or morphometrics in nonischemic dilated cardiomyopathy (NIDCM). It was a prospective study consisting of patients with
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Left ventricular strain changes at high altitude in rats: a cardiac magnetic resonance tissue tracking imaging study BMC Cardiovasc. Disord. (IF 2.1) Pub Date : 2024-04-24 Yanqiu Sun, Chenhong Zhang, Bo He, Lei Wang, Dengfeng Tian, Zhiqiang Kang, Lixin Chen, Ruiwen Li, Jialiang Ren, Yong Guo, Yonghai Zhang, Dingda Duojie, Qiang Zhang, Fabao Gao
Long-term exposure to a high altitude environment with low pressure and low oxygen could cause abnormalities in the structure and function of the heart. Myocardial strain is a sensitive indicator for assessing myocardial dysfunction, monitoring myocardial strain is of great significance for the early diagnosis and treatment of high altitude heart-related diseases. This study applies cardiac magnetic
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Ventricular apical wall rupture and ventricular aneurysm formation concurrent with ventricular septal dissection and rupture due to ST-segment elevation myocardial infarction: a case report BMC Cardiovasc. Disord. (IF 2.1) Pub Date : 2024-04-23 Qianqian Wang, Jingwei Zhou
The most common mechanical complications of acute myocardial infarction include free-wall rupture, ventricular septal rupture (VSR), papillary muscle rupture and pseudoaneurysm. It is rare for a patient to experience more than one mechanical complication simultaneously. Here, we present a case of ST-segment elevation myocardial infarction (STEMI) complicated with three mechanical complications, including
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Mir-195-5p targets Smad7 regulation of the Wnt/β-catenin pathway to promote osteogenic differentiation of vascular smooth muscle cells BMC Cardiovasc. Disord. (IF 2.1) Pub Date : 2024-04-23 Wei Lin, Lianglei Hou, Jialyu Tang, Anwu Huang, Zhuyin Jia
In this study, we sought to investigate the mechanisms of action of miR-195-5p in the osteogenic differentiation of vascular smooth muscle cells (VSMCs), and thereby provide novel insights and a reference for the targeted therapy of arterial media calcification. VSMC differentiation was induced using sodium β-glycerophosphate, and we investigated the effects of transfecting cells with miR-195-5p mimics
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Whole-exome sequencing revealed a likely pathogenic variant in NF1 causing neurofibromatosis type I and Arrhythmogenic Cardiomyopathy BMC Cardiovasc. Disord. (IF 2.1) Pub Date : 2024-04-23 Maryam Pourirahim, Golnaz Houshmand, Leyla Abdolkarimi, Majid Maleki, Samira Kalayinia
Neurofibromatosis type I (NF1) is a genetic disorder characterized by the tumor’s development in nerve tissue. Complications of NF1 can include pigmented lesions, skin neurofibromas, and heart problems such as cardiomyopathy. In this study, we performed whole-exome sequencing (WES) on an Iranian patient with NF1 to identify the genetic cause of the disease. Following clinical assessment, WES was used
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A case report of ventricular fibrillation following Shockwave intravascular lithotripsy during percutaneous coronary intervention BMC Cardiovasc. Disord. (IF 2.1) Pub Date : 2024-04-23 Lars Jakobsen, Evald Høj Christiansen, Troels Thim
Shockwave intravascular lithotripsy (S-IVL) is widely used during percutaneous coronary intervention (PCI) of calcified coronary arteries. Ventricular capture beats during S-IVL are common but arrhythmias are rare. A 75-year-old woman was scheduled for PCI to a short, heavily calcified chronic total occlusion of the right coronary artery. After wiring of the occlusion, S-IVL was used to predilated
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Burden of cardiac arrhythmias in patients with acute myocardial infarction and their impact on hospitalization outcomes: insights from China acute myocardial infarction (CAMI) registry BMC Cardiovasc. Disord. (IF 2.1) Pub Date : 2024-04-23 Xu Xu, Zhao Wang, Jingang Yang, Xiaohan Fan, Yuejin Yang
The coexistence of cardiac arrhythmias in patients with acute myocardial infarction (AMI) usually exhibits poor prognosis. However, there are few contemporary data available on the burden of cardiac arrhythmias in AMI patients and their impact on in-hospital outcomes. The present study analyzed data from the China Acute Myocardial Infarction (CAMI) registry involving 23,825 consecutive AMI patients
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An interesting electrocardiogram caused by lead reversal BMC Cardiovasc. Disord. (IF 2.1) Pub Date : 2024-04-20 Changjun Li, Nan Wang, Qinghua Chang, Dianzhu Pan
During normal sinus rhythm, atrial depolarization is conducted from right atrium to left atrium through Bachmann’s bundle, and a normal P wave axis which is measured on the frontal plane is between 0º and + 75º. The change of P wave polarity is helpful for the analysis of origin point. We report a patient with negative P wave in lead I. The characteristics of QRS complex in leads V1 to V6 are helpful
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Association between triglyceride glucose and acute kidney injury in patients with acute myocardial infarction: a propensity score‑matched analysis BMC Cardiovasc. Disord. (IF 2.1) Pub Date : 2024-04-20 Dabei Cai, Tingting Xiao, Qianwen Chen, Qingqing Gu, Yu Wang, Yuan Ji, Ling Sun, Jun Wei, Qingjie Wang
Acute kidney injury (AKI) in patients with acute myocardial infarction (AMI) often indicates a poor prognosis. This study aimed to investigate the association between the TyG index and the risk of AKI in patients with AMI. Data were taken from the Medical Information Mart for Intensive Care (MIMIC) database. A 1:3 propensity score (PS) was set to match patients in the AKI and non-AKI groups. Multivariate
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Days alive and out of hospital for adult female and male cardiac surgery patients: a population-based cohort study BMC Cardiovasc. Disord. (IF 2.1) Pub Date : 2024-04-20 Angela Jerath, Christopher J. D. Wallis, Stephen Fremes, Vivek Rao, Terrence M. Yau, Kiyan Heybati, Douglas S. Lee, Harindra C. Wijeysundera, Jason Sutherland, Peter C. Austin, Duminda N. Wijeysundera, Dennis T. Ko
Research shows women experience higher mortality than men after cardiac surgery but information on sex-differences during postoperative recovery is limited. Days alive and out of hospital (DAH) combines death, readmission and length of stay, and may better quantify sex-differences during recovery. This main objective is to evaluate (i) how DAH at 30-days varies between sex and surgical procedure, (ii)
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Machine learning approach for predicting cardiovascular disease in Bangladesh: evidence from a cross-sectional study in 2023 BMC Cardiovasc. Disord. (IF 2.1) Pub Date : 2024-04-18 Sorif Hossain, Mohammad Kamrul Hasan, Mohammad Omar Faruk, Nelufa Aktar, Riyadh Hossain, Kabir Hossain
Cardiovascular disorders (CVDs) are the leading cause of death worldwide. Lower- and middle-income countries (LMICs), such as Bangladesh, are also affected by several types of CVDs, such as heart failure and stroke. The leading cause of death in Bangladesh has recently switched from severe infections and parasitic illnesses to CVDs. The study dataset comprised a random sample of 391 CVD patients' medical
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Atrial fibrillation: real-life experience of a rhythm control with electrical cardioversion in a community hospital BMC Cardiovasc. Disord. (IF 2.1) Pub Date : 2024-04-17 Artemiy Okhotin, Maxim Osipov, Vasilij Osipov, Anton Barchuk
Atrial fibrillation is the most prevalent sustained cardiac arrhythmia. Electrical cardioversion, a well-established part of the rhythm control strategy, is probably underused in community settings. Here, we describe its use, safety, and effectiveness in a cohort of patients with atrial fibrillation treated in rural settings. It is a retrospective cohort study. Data on all procedures from January 1
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The causal relationship between thoracic aortic aneurysm and immune cells: a mendelian randomization study BMC Cardiovasc. Disord. (IF 2.1) Pub Date : 2024-04-16 Guoli Liu, Sha Pan, Hongli Xia, Mincai Li, Ansen Wu
One of the pathogenic causes of thoracic aortic aneurysm (TAA), a dangerous vascular condition that can cause aortic rupture, is autoimmune disorders. Currently, immune cell clustering is becoming more and more refined, and the specific immune cell phenotypes involved are yet unknown. Here, we want to clarify the causal link between TAA risk and 731 immune cell traits. There was a Mendelian randomization
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Transgenic human C-reactive protein affects oxidative stress but not inflammation biomarkers in the aorta of spontaneously hypertensive rats BMC Cardiovasc. Disord. (IF 2.1) Pub Date : 2024-04-16 Ivana Nemeckova, Samira Eissazadeh, Jana Urbankova Rathouska, Jan Silhavy, Hana Malinska, Michal Pravenec, Petr Nachtigal
C-reactive protein (CRP) is an acute inflammatory protein detected in obese patients with metabolic syndrome. Moreover, increased CRP levels have been linked with atherosclerotic disease, congestive heart failure, and ischemic heart disease, suggesting that it is not only a biomarker but also plays an active role in the pathophysiology of cardiovascular diseases. Since endothelial dysfunction plays
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Beneficial effects of time-restricted fasting on cardiovascular disease risk factors: a meta-analysis BMC Cardiovasc. Disord. (IF 2.1) Pub Date : 2024-04-16 Zhengqi Qiu, Emma Yun Zhi Huang, Yufei Li, Ying Xiao, Yancheng Fu, Jun Du, Juntao Kan
Cardiovascular disease continues to be a leading cause of mortality worldwide, highlighting the need to explore innovative approaches to improve cardiovascular health outcomes. Time-restricted fasting (TRF) is a dietary intervention that involves limiting the time window for food consumption. It has gained attention for its potential benefits on metabolic health and weight management. This study aims
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Regular transient limb ischemia improves endothelial function and inhibits endothelial cell apoptosis to prevent atherosclerosis in rabbit BMC Cardiovasc. Disord. (IF 2.1) Pub Date : 2024-04-16 Nan-rong Zhang, Yi Wen, Jing Li, Wan-jun Zheng, San-qing Jin
Regular transient limb ischemia (RTLI) can prevent atherosclerosis (AS) progression in hypercholesterolemic rabbits. This study aimed to investigate the minimum effective intensity and possible mechanisms of RTLI for preventing atherosclerosis. Eighty rabbits were divided into eight groups: normal (N), high cholesterol (H), three RTLI [three RTLI cycles every other day (R3qod), three RTLI cycles daily
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Reevaluating Adiponectin’s impact on obesity hypertension: a Chinese case-control study BMC Cardiovasc. Disord. (IF 2.1) Pub Date : 2024-04-13 Ou Wu, Xi Lu, Jianhang Leng, Xingyu Zhang, Wei Liu, Fenfang Yang, Hu Zhang, Jiajia Li, Saber Khederzadeh, Xiaodong Liu, Chengda Yuan
Obesity and hypertension are major risk factors for cardiovascular diseases that affect millions of people worldwide. Both conditions are associated with chronic low-grade inflammation, which is mediated by adipokines such as adiponectin. Adiponectin is the most abundant adipokine that has a beneficial impact on metabolic and vascular biology, while high serum concentrations are associated with some
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Serum PM20D1 levels in patients with idiopathic pulmonary arterial hypertension and its clinical significance BMC Cardiovasc. Disord. (IF 2.1) Pub Date : 2024-04-13 Lin Wang, Jiaxiang Liu, Liufang Zhou, Qingmei Fu
This study aimed to investigate the serum levels of Peptidase M20 domain containing 1 (PM20D1) in idiopathic pulmonary arterial hypertension (IPAH) patients and examine its association with lipid metabolism, echocardiography, and hemodynamic parameters. This prospective observational research enrolled 103 IPAH patients from January 2018 to January 2022. Enzyme-linked immunosorbent assay (ELISA) was
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Trajectory of cardiac troponin T following moderate-to-severe COVID-19 and the association with cardiac abnormalities BMC Cardiovasc. Disord. (IF 2.1) Pub Date : 2024-04-13 Tarjei Øvrebotten, Albulena Mecinaj, Knut Stavem, Waleed Ghanima, Eivind Brønstad, Michael T Durheim, Tøri V. Lerum, Tony Josefsen, Jostein Grimsmo, Siri L. Heck, Torbjørn Omland, Charlotte B. Ingul, Gunnar Einvik, Peder L. Myhre
COVID-19 has been associated with cardiac troponin T (cTnT) elevations and changes in cardiac structure and function, but the link between cardiac dysfunction and high-sensitive cardiac troponin T (hs-cTnT) in the acute and convalescent phase is unclear. To assess whether hs-cTnT concentrations are associated with cardiac dysfunction and structural abnormalities after hospitalization for COVID-19,
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The burden and natural history of cardiac pathology at TB diagnosis in a high-HIV prevalence district in Zambia: protocol for the TB-Heart study BMC Cardiovasc. Disord. (IF 2.1) Pub Date : 2024-04-10 Marcello S. Scopazzini, Pamela Chansa, Edith D. Majonga, Nina Bual, Albertus Schaap, Kondwelani J. Mateyo, Remmy Musukuma, Veronica Mweemba, Maina Cheeba, Chipili C. Mwila, Lucheka Sigande, Isabel Banda, Joseph Ngulube, Kwame Shanaube, Dominik Zenner, Helen Ayles, Anoop S. V. Shah
Tuberculosis (TB) continues to be a major cause of death across sub-Saharan Africa (SSA). In parallel, non-communicable disease and especially cardiovascular disease (CVD) burden has increased substantially in the region. Cardiac manifestations of TB are well-recognised but the extent to which they co-exist with pulmonary TB (PTB) has not been systematically evaluated. The aim of this study is to improve
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The association between C-reactive protein and coronary artery calcification: a systematic review and meta-analysis BMC Cardiovasc. Disord. (IF 2.1) Pub Date : 2024-04-10 Amirhossein Tajani, Masoumeh Sadeghi, Navid Omidkhoda, Amir Hooshang Mohammadpour, Sara Samadi, Vahid Jomehzadeh
While coronary artery calcification (CAC) is recognized as a reliable marker for coronary atherosclerosis, the relationship between the concentration of C-reactive protein (CRP) and the incidence and progression of CAC remains controversial. PubMed, Embase, Web of Science, and Scopus were systematically searched to identify relevant observational studies until October 2023. The methodological quality
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Focal ischemic myocardial fibrosis assessed by late gadolinium enhancement cardiovascular magnetic resonance in patients with hypertrophic cardiomyopathy BMC Cardiovasc. Disord. (IF 2.1) Pub Date : 2024-04-09 Yang Zhi, Fu-dan Gui, Meng Xue, Yi-tian Long, Wen Miao, You Yi, Liang-chao Gao, Fu Bing, Shu-yue Pan
In patients with hypertrophic cardiomyopathy (HCM), ischemic myocardial fibrosis assessed by late gadolinium enhancement (I-LGE) using cardiovascular magnetic resonance (CMR) have been reported. However, the clinical significance of I-LGE has not been completely understood. We aim to evaluate the I-LGE differ phenotypically from HCM without LGE or nonischemic myocardial fibrosis assessed by late gadolinium
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Impacts of ABCG2 loss of function variant (p. Gln141Lys, c.421 C > A, rs2231142) on lipid levels and statin efficiency: a systematic review and meta-analysis BMC Cardiovasc. Disord. (IF 2.1) Pub Date : 2024-04-08 Yang Liu, Yuan Chen, Baozhu Wei, Hang Li, Yuanyuan Peng, Zhi Luo
The latest evidence indicates that ATP-binding cassette superfamily G member 2 (ABCG2) is critical in regulating lipid metabolism and mediating statin or cholesterol efflux. This study investigates whether the function variant loss within ABCG2 (rs2231142) impacts lipid levels and statin efficiency. PubMed, Cochrane Library, Central, CINAHL, and ClinicalTrials.gov were searched until November 18, 2023
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Assessment of subclinical left ventricular systolic and diastolic dysfunction in patients with type 2 diabetes mellitus under follow-up at Tikur Anbessa specialized hospital, Ethiopia: a case-control study BMC Cardiovasc. Disord. (IF 2.1) Pub Date : 2024-04-06 Tigist Seleshi, Theodros Alemneh, Dufera Mekonnen, Demu Tesfaye, Sura Markos, Yitagesu Getachew, Konno Taddese, Senbeta Guteta
Individuals with diabetes mellitus are at increased risk of cardiovascular diseases, which in turn are the most common cause of morbidity and mortality in the diabetic population. A peculiar feature of cardiovascular diseases in this population is that they can have significant cardiac disease while remaining asymptomatic. There is a paucity of data regarding subclinical cardiac imaging features among
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IgG4-Related disease with diffuse myopericardial involvement- value of CMR: a case report and literature review of cardiac involvement BMC Cardiovasc. Disord. (IF 2.1) Pub Date : 2024-04-06 Golnaz Houshmand, Najme-Sadat Moosavi, Amirhossein Shahbazkhani, Hamidreza Pouraliakbar
IgG4-related disease is a fibro-inflammatory disorder with an unknown etiology, which can affect multiple organ systems, including the cardiovascular system. While most reported cases of cardiovascular involvement are primarily associated with the aorta, there have been sporadic reports of isolated cardiac involvement. This paper presents a documented case of IgG4-related systemic disease with symptoms
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A new nomogram to predict in-hospital mortality in patients with acute decompensated chronic heart failure and diabetes after 48 Hours of Intensive Care Unit BMC Cardiovasc. Disord. (IF 2.1) Pub Date : 2024-04-06 Linlin Liu, Lei Feng, Cheng Lu, Jiehan Zhang, Ya Zhao, Lin Che
The study set out to develop an accurate and clinically valuable prognostic nomogram to assess the risk of in-hospital death in patients with acute decompensated chronic heart failure (ADCHF) and diabetes. We extracted clinical data of patients diagnosed with ADCHF and diabetes from the Medical Information Mart for Intensive Care III database. Risk variables were selected utilizing least absolute shrinkage
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Rationale and design of the SPRING trail: effectivity and safety of Pfo closuRe vs medIcine in alleviatiNg migraine, a multicenter, randomized and open-label trail BMC Cardiovasc. Disord. (IF 2.1) Pub Date : 2024-04-05 Yang Zi-yang, Li Hezhi, Luo Dongling, Wang Ximeng, Zhang Caojin
Migraine is a leading cause of disability worldwide. Several retrospective studies have suggested that the closure of the Patent Foramen Ovale (PFO) may provide relief from migraines. However, three randomized controlled trials did not meet their primary endpoints regarding migraine cessation, reduction in monthly migraine days, and responder rates. The SPRING study is a multicenter, prospective, randomized
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HAPLN1 knockdown inhibits heart failure development via activating the PKA signaling pathway BMC Cardiovasc. Disord. (IF 2.1) Pub Date : 2024-04-05 Tao Yan, Shushuai Song, Wendong Sun, Yiping Ge
Heart failure (HF) is a heterogeneous syndrome that affects millions worldwide, resulting in substantial health and economic burdens. However, the molecular mechanism of HF pathogenesis remains unclear. HF-related key genes were screened by a bioinformatics approach.The impacts of HAPLN1 knockdown on Angiotensin II (Ang II)-induced AC16 cells were assessed through a series of cell function experiments
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Serum albumin and cardiovascular disease: a Mendelian randomization study BMC Cardiovasc. Disord. (IF 2.1) Pub Date : 2024-04-05 Taoke Huang, Zhifeng An, Ziru Huang, Weiyang Gao, Benchuan Hao, Juan Xu
An increasing body of evidence suggests that serum albumin levels play a role in cardiovascular diseases. However, the specific causal relationship between serum albumin levels and cardiovascular disease remains partially unknown. Mendelian randomization (MR) was employed in this study to examine potential causal relationships between instrumental variables and cardiovascular diseases. Specifically
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Heart surgery over two decades: what we have learned about results and changing risks BMC Cardiovasc. Disord. (IF 2.1) Pub Date : 2024-04-05 Masih Tajdini, Amir Hossein Behnoush, Mina Pashang, Mana Jameie, Amirmohammad Khalaji, Saeed Sadeghian, Ali Vasheghani-Farahani, Hamidreza Poorhosseini, Farzad Masoudkabir, Kaveh Hosseini, Saeed Davoodi, Mohammad Sahebjam, Khosro Barkhordari, Haleh Ashraf, Akbar Shafiei, Abbasali Karimi
Using the cardiac surgery database is of high importance in referral centers and can lead to a better quality of care for patients. Tehran Heart Center (THC) is a cardiovascular referral center that was inaugurated in 2001. In this report, we aimed to present the third report of trends in patients' cardiovascular risk factors and surgical procedures from 2002 to 2021 that have been gathered for all
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Sex-based association between high-density lipoprotein cholesterol and adverse outcomes after coronary artery bypass grafting BMC Cardiovasc. Disord. (IF 2.1) Pub Date : 2024-04-05 Sara Montazeri Namin, Ali Moradi, Hamed Tavolinejad, Ali Vasheghani-Farahani, Arash Jalali, Mina Pashang, Saeed Sadeghian, Jamshid Bagheri, Soheil Mansourian, Mehdi Mehrani, Kaveh Hosseini, Sina Rashedi, Masih Tajdini
High-density lipoprotein cholesterol (HDL-C) is shown to be an independent protective factor against coronary artery diseases (CAD). Yet there are limited studies focusing on the association between HDL-C and coronary artery bypass graft (CABG) surgery outcomes. Low levels of HDL-C are associated with higher incidence of adverse outcomes in patients undergoing CABG. This registry-based study included
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Investigating the interplay of smoking, cardiovascular risk factors, and overall cardiovascular disease risk: NHANES analysis 2011–2018 BMC Cardiovasc. Disord. (IF 2.1) Pub Date : 2024-04-04 Athumani Mambo, Yulu Yang, Emmerenceana Mahulu, Zhou Zihua
This study explores the intricate relationship between smoking, cardiovascular disease (CVD) risk factors and their combined impact on overall CVD risk, utilizing data from NHANES 2011–2018. Participants were categorized based on the presence of CVD, and we compared their demographic, social, and clinical characteristics. We utilized logistic regression models, receiver operating characteristics (ROC)
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Acute coronary syndrome patterns in the Young: risk factor profile and in-hospital outcomes in a tertiary referral hospital in Kenya BMC Cardiovasc. Disord. (IF 2.1) Pub Date : 2024-04-03 Nadeem Kassam, Mzee Ngunga, Mohamed Varwani, Miriam Msunza, Mohamed Jeilan
Acute coronary syndrome (ACS) accounts for coronary artery disease (CAD) –related morbidity and mortality. There has been growing concern about the rising incidence of ACS among young individuals globally both in developed and developing countries, including Sub-Saharan Africa. This group’s phenotypic characteristics; risk factors and clinical outcomes are not well described. contextual and regional
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Superoxide dismutases: marker in predicting reduced left ventricular ejection fraction in patients with type 2 diabetes and acute coronary syndrome BMC Cardiovasc. Disord. (IF 2.1) Pub Date : 2024-04-03 Xiu-Yun Jiang, Qing Chen, Xiao-Yu Chen, Qiu-Ying Sun, Fei Jing, Hai-Qing Zhang, Jin Xu, Xiao-Hong Li, Qing-Bo Guan
To examine the prognostic value of superoxide dismutase (SOD) activity for monitoring reduced left ventricular ejection fraction(LVEF)in the patients with type 2 diabetes and acute coronary syndrome (ACS). The population of this cross-sectional study included 2377 inpatients with type 2 diabetes who had an ACS admitted to the Shandong Provincial Hospital Affiliated to Shandong First Medical University
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Shifting perspectives in coronary involvement of polyarteritis nodosa: case of 3-vessel occlusion treated with 4-vessel CABG and review of literature BMC Cardiovasc. Disord. (IF 2.1) Pub Date : 2024-04-02 Dylan J. Walter, Grace E. Bigham, Steven Lahti, Syed W. Haider
Polyarteritis Nodosa (PAN) is a systemic vasculitis (SV) historically thought to spare the coronary arteries. Coronary angiography and contemporary imaging reveal coronary stenosis and dilation, which are associated with significant morbidity and mortality. Coronary arteries in PAN are burdened with accelerated atherosclerosis from generalized inflammation adding to an inherent arteritic process. Traditional
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Systemic immune-inflammation index as a novel predictor of major adverse cardiovascular events in patients undergoing percutaneous coronary intervention: a meta-analysis of cohort studies BMC Cardiovasc. Disord. (IF 2.1) Pub Date : 2024-04-01 Chunyu Zhang, Minghao Li, Lin Liu, Li Deng, Xie Yulei, Yi Zhong, Bin Liao, Lu Yu, Jian Feng
The Systemic Immune-Inflammation Index (SII), a novel marker of inflammation based on neutrophil, platelet, and lymphocyte counts, has demonstrated potential prognostic value in patients undergoing percutaneous coronary intervention (PCI). Our aim was to assess the correlation between the SII and major adverse cardiovascular events following percutaneous coronary intervention. We searched PubMed, Web
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Double trouble - dual outflow tract obstruction in congenital heart disease: a case report BMC Cardiovasc. Disord. (IF 2.1) Pub Date : 2024-04-01 Kanchan Maggo, Aanchal Bhayana, Pranav Gupta, Vidushi Gupta, Animesh Verma, Amita Malik
Double chambered right ventricle is a rare congenital heart disease that is characterised by the presence of an anomalous muscle bundle that divides the right ventricle into a low pressure superior (distal) chamber and a high pressure inferior (proximal) chamber. It is found in association with a ventricular septal defect in 90% cases with other associations being tetralogy of Fallot, transposition
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Acute myocardial infarction due to giant coronary artery aneurysm and arteriovenous fistula: a challenging case report and review of the literature BMC Cardiovasc. Disord. (IF 2.1) Pub Date : 2024-04-01 A. Vassilikou, MP Xenitopoulou, K. Ziampa, AP Evangeliou, S. Mitsiadis, A. Syrnioti, G. Petrakis, P. Tossios, V. Vassilikos, S. Tzikas
A coronary artery aneurysm (CAA) is an abnormal dilation of a coronary artery segment often accompanied by coronary artery fistula (CAF), leading to communication between a coronary artery and a cardiac chamber or a part of the coronary venous system. Both CAAs and CAFs can present with symptoms and signs of myocardial ischemia and infarction. We describe the case of a 46-year-old woman with non-ST-elevation
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Correlation between the cardiometabolic index and arteriosclerosis in patients with type 2 diabetes mellitus BMC Cardiovasc. Disord. (IF 2.1) Pub Date : 2024-03-27 Chaoyan Tang, Tianjiao Pang, Chaozhi Dang, Hui Liang, Junfeng Wu, Xiaofang Shen, Lielin Wang, Ruiqiong Luo, Haiyun Lan, Ping Zhang
The cardiometabolic index (CMI) is a new metric derived from the triglyceride-glucose index and body mass index and is considered a potential marker for cardiovascular risk assessment. This study aimed to examine the correlation between the CMI and the presence and severity of arteriosclerosis in patients with type 2 diabetes mellitus (T2DM). This study involved 2243 patients with T2DM. The CMI was
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Upregulation of CIRP by its agonist prevents the development of heart failure in myocardial infarction rats BMC Cardiovasc. Disord. (IF 2.1) Pub Date : 2024-03-27 Jingjing Zhang, Tao Liu, Yanzhao Wei, Jianye Peng, Gaofeng Zeng, Peng Zhong
Downregulated expression of cold-inducible RNA binding protein (CIRP), a stress-response protein, has been demonstrated in the hearts of patients with heart failure (HF). However, whether CIRP plays a critical role in the pathogenesis of HF remains unknown. Zr17-2 is a recently identified CIRP agonist, which can enhance the expression of CIRP in hearts. Herein, we evaluated the effects of zr17-2 on
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A national perspective on cardiovascular diseases in Saudi Arabia BMC Cardiovasc. Disord. (IF 2.1) Pub Date : 2024-03-27 Bader A. Alqahtani, Aqeel M. Alenazi
Cardiovascular diseases (CVDs) are common chronic conditions that lead to morbidity and mortality worldwide. However, there are no recent national or regional reports about CVDs in Saudi Arabia. Therefore, this study aimed to estimate the national and regional prevalence rates of CVDs among the Saudi population. This study used data from an ongoing household health survey conducted by the General Authority
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Bioinformatics integration reveals key genes associated with mitophagy in myocardial ischemia-reperfusion injury BMC Cardiovasc. Disord. (IF 2.1) Pub Date : 2024-03-27 Zhian Chen, Tianying Liu, Hao Yuan, Han Sun, Sitong Liu, Shuai Zhang, Li Liu, Shuang Jiang, Yong Tang, Zhi Liu
Myocardial ischemia is a prevalent cardiovascular disorder associated with significant morbidity and mortality. While prompt restoration of blood flow is essential for improving patient outcomes, the subsequent reperfusion process can result in myocardial ischemia–reperfusion injury (MIRI). Mitophagy, a specialized autophagic mechanism, has consistently been implicated in various cardiovascular disorders
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Early and mid-term outcomes of open thoracoabdominal aortic aneurysm repair after thoracic endovascular aortic repair BMC Cardiovasc. Disord. (IF 2.1) Pub Date : 2024-03-26 Ji Lin, Wei Liu, Cheng-Wei Yang, Kaitao Jian, Yu Xia, Hao Peng, Bin You, Li-Zhong Sun
To evaluate the early and mid-term outcomes of open repair in patients with thoracoabdominal aortic aneurysm (TAAA) after thoracic endovascular aortic repair (TEVAR). This was a retrospective single center study. Data were retrospectively collected and analyzed for consecutive patients undergoing open TAAA repair (TAAAR) after TEVAR from November 2016 to June 2021. Indications for TAAAR included aneurysm
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PATHFINDER-CHD: prospective registry on adults with congenital heart disease, abnormal ventricular function, and/or heart failure as a foundation for establishing rehabilitative, prehabilitative, preventive, and health-promoting measures: rationale, aims, design and methods BMC Cardiovasc. Disord. (IF 2.1) Pub Date : 2024-03-26 Sebastian Freilinger, Harald Kaemmerer, Robert D. Pittrow, Stefan Achenbach, Stefan Baldus, Oliver Dewald, Peter Ewert, Annika Freiberger, Matthias Gorenflo, Frank Harig, Christopher Hohmann, Stefan Holdenrieder, Jürgen Hörer, Michael Huntgeburth, Michael Hübler, Niko Kohls, Frank Klawonn, Rainer Kozlik-Feldmann, Renate Kaulitz, Dirk Loßnitzer, Friedrich Mellert, Nicole Nagdyman, Johannes Nordmeyer
Adults with congenital heart defects (ACHD) globally constitute a notably medically underserved patient population. Despite therapeutic advancements, these individuals often confront substantial physical and psychosocial residua or sequelae, requiring specialized, integrative cardiological care throughout their lifespan. Heart failure (HF) is a critical challenge in this population, markedly impacting
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A decrease in integrin α5β1/FAK is associated with increased apoptosis of aortic smooth muscle cells in acute type a aortic dissection BMC Cardiovasc. Disord. (IF 2.1) Pub Date : 2024-03-26 Mingming Xue, Lingyu Xing, Yilin Yang, Mian Shao, Fengqing Liao, Feixiang Xu, Yumei Chen, Sheng Wang, Bin Chen, Chenling Yao, Guorong Gu, Chaoyang Tong
Acute type A aortic dissection (AAAD) is a devastating disease. Human aortic smooth muscle cells (HASMCs) exhibit decreased proliferation and increased apoptosis, and integrin α5β1 and FAK are important proangiogenic factors involved in regulating angiogenesis. The aim of this study was to investigate the role of integrin α5β1 and FAK in patients with AAAD and the potential underlying mechanisms. Aortic
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A nomogram model for predicting intramyocardial hemorrhage post-PCI based on SYNTAX score and clinical features BMC Cardiovasc. Disord. (IF 2.1) Pub Date : 2024-03-25 Yin-shuang Yang, De-yang Xi, Yang Duan, Miao Yu, Kai Liu, Yan-kai Meng, Chun-feng Hu, Shu-guang Han, Kai Xu
The aim of this study is to develop a nomogram model for predicting the occurrence of intramyocardial hemorrhage (IMH) in patients with Acute Myocardial Infarction (AMI) following Percutaneous Coronary Intervention (PCI). The model is constructed utilizing clinical data and the SYNTAX Score (SS), and its predictive value is thoroughly evaluated. A retrospective study was conducted, including 216 patients
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Predictors of improvement in left ventricular systolic function after catheter ablation in patients with persistent atrial fibrillation complicated with heart failure BMC Cardiovasc. Disord. (IF 2.1) Pub Date : 2024-03-23 Xinliang Zhao, Xiaoqin Hu, Wei Bao, Shuo Huang, Fei Li, Chen Liu, Liqi Ge, Quan Zhang, Chaoqun Zhang, Chengzong Li
The current management of patients with atrial fibrillation (AF) and concomitant heart failure (HF) remains a significant challenge. Catheter ablation (CA) has been shown to improve left ventricular ejection fraction (LVEF) in these patients, but which patients can benefit from CA is still poorly understood. The aim of our study was to determine the predictors of improved ejection fraction in patients
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Predictive value of estimated plasma volume for postoperative hypotension in percutaneous intramyocardial septal radiofrequency ablation treating for hypertrophic obstructive cardiomyopathy BMC Cardiovasc. Disord. (IF 2.1) Pub Date : 2024-03-22 Bo Shan, Jing Li, Zhangwei Shi, Chao Han, Juan Zhang, Jia Zhao, Rui Hu, Liwen Liu, Shengjun Ta
Estimated plasma volume status (ePVS) estimated by the Duarte formula is associated with clinical outcomes in patients with heart failure. It remains unclear the predictive value of the ePVS to the postoperative hypotension (POH) in percutaneous intramyocardial septal radiofrequency ablation (PIMSRA) treating hypertrophic obstructive cardiomyopathy (HOCM). Data of HOCM patients who underwent PIMSRA
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Low HDL cholesterol and the eNOS Glu298Asp polymorphism are associated with inducible myocardial ischemia in patients with suspected stable coronary artery disease BMC Cardiovasc. Disord. (IF 2.1) Pub Date : 2024-03-22 Cecilia Vecoli, Chiara Caselli, Martina Modena, Giancarlo Todiere, Rosa Poddighe, Serafina Valente, Fabrizio Bandini, Andrea Natali, Lorenzo Ghiadoni, Aldo Clerico, Concetta Prontera, Simona Vittorini, Nicoletta Botto, Michele Emdin, Danilo Neglia
The endothelial nitric oxide synthase (eNOS) gene deficiency is known to cause impaired coronary vasodilating capability in animal models. In the general clinical population, the eNOS gene polymorphisms, able to affect eNOS activity, were associated with cardiometabolic risk features and prevalence of coronary artery disease (CAD). To investigate the association of eNOS Glu298Asp gene polymorphism
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Overcoming barriers for left atrial appendage thrombus: a systematic review of left atrial appendage closure BMC Cardiovasc. Disord. (IF 2.1) Pub Date : 2024-03-21 Zixi Zhang, Jiabao Zhou, Qiuzhen Lin, Cancan Wang, Yunying Huang, Yongguo Dai, Wanyun Zuo, Na Liu, Yichao Xiao, Qiming Liu
Approximately 90% of intracardial thrombi originate from the left atrial appendage in non-valvular atrial fibrillation patients. Even with anticoagulant therapy, left atrial appendage thrombus (LAAT) still occurs in 8% of patients. While left atrial appendage closure (LAAC) could be a promising alternative, the current consensus considers LAAT a contraindication to LAAC. However, the feasibility and
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Association of red cell distribution width/albumin ratio and in hospital mortality in patients with atrial fibrillation base on medical information mart for intensive care IV database BMC Cardiovasc. Disord. (IF 2.1) Pub Date : 2024-03-21 Li-ya Pan, Jing Song
Atrial fibrillation (AF) is a common cardiac arrhythmia. The ratio of red cell distribution width (RDW) to albumin has been recognized as a reliable prognostic marker for poor outcomes in a variety of diseases. However, the evidence regarding the association between RDW to albumin ratio (RAR) and in hospital mortality in patients with AF admitted to the Intensive Care Unit (ICU) currently was unclear
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The association between long-term exposure to ambient PM2.5 and high-density lipoprotein cholesterol level among chinese middle-aged and older adults BMC Cardiovasc. Disord. (IF 2.1) Pub Date : 2024-03-21 Chaolin Liu, Yong Qiao
Recently, the impact of PM2.5 on human health has been intensively studied, especially the respiratory system. High-density lipoprotein plays a crucial role in removing excess cholesterol from cells and transporting it to the liver for excretion. However, the effects of ambient PM2.5 on high-density lipoprotein (HDL) level have not been further studied. Our research aims to investigate the potential
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APOE ε4 carriage associates with improved myocardial performance from adolescence to older age BMC Cardiovasc. Disord. (IF 2.1) Pub Date : 2024-03-21 Constantin-Cristian Topriceanu, Mit Shah, Matthew Webber, Fiona Chan, Hunain Shiwani, Marcus Richards, Jonathan Schott, Nishi Chaturvedi, James C. Moon, Alun D. Hughes, Aroon D. Hingorani, Declan P. O’Regan, Gabriella Captur
Although APOE ε4 allele carriage confers a risk for coronary artery disease, its persistence in humans might be explained by certain survival advantages (antagonistic pleiotropy). Combining data from ~ 37,000 persons from three older age British cohorts (1946 National Survey of Health and Development [NSHD], Southall and Brent Revised [SABRE], and UK Biobank) and one younger age cohort (Avon Longitudinal
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Levels of adherence to treatment, illness perception and acceptance of illness in patients with coronary artery disease - descriptive and correlational study BMC Cardiovasc. Disord. (IF 2.1) Pub Date : 2024-03-20 Farzad Dugunchi, Shiv Kumar Mudgal, Zohreh Hosseini Marznaki, Hoda Shirafkan, Saeed Abrotan, Fateme Jafarian, Roghayeh Pourkia
Understanding the disease and its acceptance significantly influence adherence to prescribed medications, a critical aspect in managing coronary artery disease (CAD). This study is designed to explore the multifaceted factors influencing medication adherence specifically in CAD patients. Of particular interest is investigating the interconnectedness between medication adherence, the perception of illness
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Association of greenspaces exposure with cardiometabolic risk factors: a systematic review and meta-analysis BMC Cardiovasc. Disord. (IF 2.1) Pub Date : 2024-03-20 Yasaman Sharifi, Sahar Sobhani, Nahid Ramezanghorbani, Moloud Payab, Behnaz Ghoreshi, Shirin Djalalinia, Zahra Nouri Ghonbalani, Mahbube Ebrahimpur, Maysa Eslami, Mostafa Qorbani
Cardiometabolic conditions are major contributors to the global burden of disease. An emerging body of evidence has associated access to and surrounding public open spaces (POS) and greenspace with cardiometabolic risk factors, including obesity, body mass index (BMI), hypertension (HTN), blood glucose (BG), and lipid profiles. This systematic review aimed to synthesize this evidence. This systematic
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Targeting myeloperoxidase to stabilize unruptured aneurysm: an imaging-guided approach BMC Cardiovasc. Disord. (IF 2.1) Pub Date : 2024-03-20 Xingchi Shi, Yuan Xue, Huiyu Wu, Chengyi Shen, Lei Zhong, Jun Lei, Zhiyang Xia, Ying Yang, Jiang Zhu
Inflammation plays a key role in pathogenesis and rupture of aneurysms. Non-invasively and dynamically monitoring aneurysm inflammation is critical. This study evaluated myeloperoxidase (MPO) as an imaging biomarker and therapeutic target for aneurysm inflammation using an elastase-induced rabbit model treated with or without 4-aminobenzoic acid hydrazide (ABAH), an irreversible inhibitor of MPO.
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Association between triglyceride-glucose index and hypertension: a cohort study based on the China Health and Nutrition Survey (2009–2015) BMC Cardiovasc. Disord. (IF 2.1) Pub Date : 2024-03-19 Su Wang, Qian Wang, Xianliang Yan
Insulin resistance (IR) may participate in the pathogenesis of hypertension by mediating low-grade systemic inflammation. The triglycerides-glucose (TyG) index has recently been suggested as a reliable alternative biochemical marker of IR compared with traditional methods. Herein, we speculated TyG index may also be associated with hypertension. Data of adults were extracted from the China Health and
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Paclitaxel-induced acute myocardial infarction: a case report and literature review BMC Cardiovasc. Disord. (IF 2.1) Pub Date : 2024-03-19 Gi Eun Kim, Ayman R. Ibrahim, Duha Shalatouni, Nadin H. Abouzeid, Fahmi Othman
Paclitaxel is a chemotherapeutic agent commonly used for ovarian, lung, breast carcinoma, and Kaposi’s sarcoma. Its common side effects include hypersensitivity reaction, bone marrow suppression, and peripheral neuropathy. However, a rare and life-threatening side effect is paclitaxel-induced myocardial infarction. A 71-year-old man with type 2 diabetes mellitus, hypertension, heavy smoking history