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Characterisation of the octogenarians presenting to the diagnostic heart failure clinic: SHEAF registry Open Heart Pub Date : 2024-04-01 Luke Thompson, Fiona Carr, Dominic Rogers, Nigel Lewis, Athanasios Charalampopoulos, Graham Fent, Pankaj Garg, Andrew J Swift, Abdallah Al-Mohammad
Introduction Heart failure (HF) incidence is increasing in older adults with high hospitalisation and mortality rates. Treatment is complicated by side effects and comorbidities. We investigated the clinical characteristics of octogenarians presenting to the HF clinic. Methods Data were collected on octogenarians (80–89 years) referred to the HF clinic in two periods. The data included demographics
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Aetiology and predictors of major bleeding events in patients with heart failure with reduced ejection fraction undergoing percutaneous coronary intervention Open Heart Pub Date : 2024-04-01 Meghana Iyer, Rohan Shah, Weili Zheng, Khaled M Ziada, Umesh Khot, Amar Krishnaswamy, Samir R Kapadia, Grant W Reed
Objectives We sought to determine the relationship between the degree of left ventricular ejection fraction (LVEF) impairment and the frequency and type of bleeding events after percutaneous coronary intervention (PCI). Design This was an observational retrospective cohort analysis. Patients who underwent PCI from 2009 to 2017 were identified from our institutional National Cardiovascular Disease Registry
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Review of codelists used to define hypertension in electronic health records and development of a codelist for research Open Heart Pub Date : 2024-04-01 Georgie May Massen, Philip W Stone, Harley H Y Kwok, Gisli Jenkins, Richard J Allen, Louise V Wain, Iain Stewart, Jennifer Kathleen Quint
Background and aims Hypertension is a leading risk factor for cardiovascular disease. Electronic health records (EHRs) are routinely collected throughout a person’s care, recording all aspects of health status, including current and past conditions, prescriptions and test results. EHRs can be used for epidemiological research. However, there are nuances in the way conditions are recorded using clinical
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New era in heart failure management: implementing cutting-edge therapies effectively Open Heart Pub Date : 2024-04-01 Anastasia Shchendrygina, Clara Saldarriaga
Pharmacological therapy for heart failure (HF) has evolved significantly in recent years. Conventional disease-modifying medical therapy HF with reduced ejection fraction (HFrEF), beta-blockers (BB), angiotensin-converting enzyme inhibitors (ACEIs) or angiotensin receptor blockers (ARBs), and mineralocorticoid receptor antagonists (MRAs), was complemented by two novel drug classes including angiotensin
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Outcomes of subsequent pregnancy in women with peripartum cardiomyopathy: a systematic review and meta-analysis Open Heart Pub Date : 2024-04-01 Matthew Aldo Wijayanto, Risalina Myrtha, Graciella Angelica Lukas, Annisa Aghnia Rahma, Shafira Nur Hanifa, Hadiqa Almas Zahira, Muhana Fawwazy Ilyas
Introduction The primary concern for women who have experienced peripartum cardiomyopathy (PPCM) is the safety of a subsequent pregnancy (SSP). To maximie decision-making, facilitate effective patient counselling, and ultimately improve maternal and fetal outcomes as a whole, it is critical to comprehend the outcomes of SSP in women who have previously experienced PPCM. This study aimed to evaluate
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Arrhythmias and cardiac MRI associations in patients with established cardiac dystrophinopathy Open Heart Pub Date : 2024-04-01 John Bourke, Margaret Tynan, Hannah Stevenson, Leslie Bremner, Oscar Gonzalez-Fernandez, Adam K McDiarmid
Aims Some patients with cardiac dystrophinopathy die suddenly. Whether such deaths are preventable by specific antiarrhythmic management or simply indicate heart failure overwhelming medical therapies is uncertain. The aim of this prospective, cohort study was to describe the occurrence and nature of cardiac arrhythmias recorded during prolonged continuous ECG rhythm surveillance in patients with established
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Virtual reality to reduce periprocedural anxiety during invasive coronary angiography: rationale and design of the VR InCard trial Open Heart Pub Date : 2024-04-01 Esther Helena Wouda Breunissen, Tjitske Diederike Groenveld, Linda Garms, Judith L Bonnes, Harry van Goor, Peter Damman
Introduction Patients undergoing invasive coronary angiography (ICA) experience anxiety due to various reasons. Procedural anxiety can lead to physiological and psychological complications, compromising patient comfort and overall procedural outcomes. Benzodiazepines are commonly used to reduce periprocedural anxiety, although the effect is modest. Virtual reality (VR) is a promising non-pharmacological
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Correction: Changes in heart failure management and long-term mortality over 10 years: observational study Open Heart Pub Date : 2024-03-01 British Cardiovascular Society
Bottle A, Newson R, Faitna P, et al . Changes in heart failure management and long-term mortality over 10 years: observational study. Open Heart 2022;9:e001888. doi: 10.1136/openhrt-2021-001888 This …
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Major bleeding in patients with atrial fibrillation treated with apixaban versus warfarin in combination with amiodarone: nationwide cohort study Open Heart Pub Date : 2024-03-01 Astrid Fritz Hansson, Angelo Modica, Henrik Renlund, Christina Christersson, Claes Held, Gorav Batra
Background Amiodarone is an established treatment for atrial fibrillation (AF) but might interfere with the metabolism of apixaban or warfarin. Therefore, the aim was to investigate the occurrence of major bleeding among patients with AF treated with amiodarone in combination with apixaban or warfarin. Methods Retrospective observational study using Swedish health registers. All patients with AF in
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OPTIMA-BP: empOwering PaTients in MAnaging Blood Pressure – protocol for a randomised parallel group study comparing use of Kvatchii web-based patient education portal as an addition to home blood pressure monitoring Open Heart Pub Date : 2024-03-01 Linsay McCallum, Stefanie Lip, Maggie Rostron, Rebecca Hanna, Nukman Bin Pg Md Salimin, Sarah Nichol, Sandosh Padmanabhan
Introduction Hypertension is the leading modifiable risk factor for cardiovascular disease and is implicated in half of all strokes and myocardial infarctions. One-third of the adults in Scotland have hypertension yet only a quarter of them have their blood pressure (BP) controlled to target (<140/90 mm Hg). Empowering patients to have a better understanding of their condition and becoming actively
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Oral anticoagulation therapy initiation in patients with atrial fibrillation in relation to world region of origin: a register-based nationwide study Open Heart Pub Date : 2024-03-01 Juliane Frydenlund, Jan Brink Valentin, Marie Norredam, Lars Frost, Sam Riahi, Kristian Hay Kragholm, Henrik Bøggild, Gregory Y H Lip, Søren Paaske Johnsen
Background Atrial fibrillation (AF) is the most common sustained arrhythmia and results in a high risk of stroke. The number of immigrants is increasing globally, but little is known about potential differences in AF care across migrant populations. Aim To investigate if initiation of oral anticoagulation therapy (OAC) differs for patients with incident AF in relation to country of origin. Methods
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Coronary artery disease and outcomes following transcatheter aortic valve implantation Open Heart Pub Date : 2024-03-01 Sameer Kurmani, Bhavik Modi, Aditya Mukherjee, David Adlam, Amerjeet Banning, Andrew Ladwiniec, Raj Rajendra, Julia Baron, Elved Roberts, Andre Ng, Iain Squire, Gerald McCann, Nilesh J Samani, Jan Kovac
Background Aortic stenosis is a life-limiting condition for which transcatheter aortic valve implantation (TAVI) is an established therapy. Coronary artery disease (CAD) is frequently found in this patient group and optimal management in these patients remains uncertain. Objectives We sought to examine the association of coexistent CAD on mortality and hospital readmission in patients undergoing TAVI
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Prevalence of transthyretin cardiac amyloidosis in patients with high-degree AV block Open Heart Pub Date : 2024-03-01 Douglas Cannie, Kush Patel, Alexandros Protonotarios, Imogen Heenan, Athanasios Bakalakos, Petros Syrris, Leon Menezes, Perry M Elliott
Objective Transthyretin amyloid cardiomyopathy (ATTR-CM) is an infiltrative cardiac disorder caused by deposition of wild type or mutated transthyretin. As ATTR-CM is associated with conduction disease, we sought to determine its prevalence in patients with idiopathic high-degree atrioventricular (AV) block requiring permanent pacemaker (PPM) implantation. Methods Consecutive patients aged 70–85 years
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Trends in transcatheter aortic valve implantation practice and clinical outcomes at an Irish tertiary referral centre Open Heart Pub Date : 2024-03-01 Richard Tanner, Daniele Giacoppo, Hassan Saber, David Barton, Declan Sugrue, Andrew Roy, Gavin Blake, Mark S Spence, Ronan Margey, Ivan P Casserly
Objective A paucity of data exists on how transcatheter aortic valve implantation (TAVI) practice has evolved in Ireland. This study sought to analyse temporal trends in patient demographics, procedural characteristics, and clinical outcomes at an Irish tertiary referral centre. Methods The prospective Mater TAVI database was divided into time tertiles based on when TAVI was performed: Group A, November
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Multimorbidity in patients with atrial fibrillation Open Heart Pub Date : 2024-03-01 Michelle Lobeek, Melissa E Middeldorp, Isabelle C Van Gelder, Michiel Rienstra
There is an escalating trend in both the incidence and prevalence of atrial fibrillation (AF). AF is linked to numerous other comorbidities, contributing to the emergence of multimorbidity. The sustained rise in multimorbidity and AF prevalences exerts a significant strain on healthcare systems globally. The understanding of the relation between multimorbidity and AF is essential to determine effective
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Comparison of troponin and natriuretic peptides in Takotsubo syndrome and acute coronary syndrome: a meta-analysis Open Heart Pub Date : 2024-03-01 Liam Steven Couch, James W Garrard, John A Henry, Rafail A Kotronias, Bashir Alaour, Giovanni Luigi De Maria, Keith M Channon, Adrian P Banning, Alexander Richard Lyon, Michael Marber, Thomas Edward Kaier
Objective Takotsubo syndrome (TTS) is an acute heart failure syndrome which resembles acute coronary syndrome (ACS) at presentation. Differentiation requires coronary angiography, but where this does not occur immediately, cardiac biomarkers may provide additional utility. We performed a meta-analysis to compare troponin and natriuretic peptides (NPs) in TTS and ACS to determine if differences in biomarker
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Diagnostic accuracy of baseline troponin and troponin change for the diagnosis of myocardial infarction complicated with heart failure Open Heart Pub Date : 2024-03-01 Matteo Serenelli, Beatrice Dal Passo, Simone Biscaglia, Paolo Tolomeo, Luca Di Ienno, Anna Cantone, Federico Sanguettoli, Roberta Campana, Federico Marchini, Matteo Arzenton, Daniele Maio, Valentino Santori, Gianluca Campo
Background The diagnosis of myocardial infarction (MI) in the presence of heart failure (HF) presents a clinical problem. While diagnostic algorithms using high-sensitivity cardiac troponin have been established for suspected MI, their accuracy in patients with HF remains uncertain. This study aims to assess the diagnostic accuracy of high-sensitivity troponin I (TnI) levels in identifying acute MI
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Efficacy of colchicine in addition to anakinra in patients with recurrent pericarditis Open Heart Pub Date : 2024-03-01 Valentino Collini, Alessandro Andreis, Marzia De Biasio, Maria De Martino, Miriam Isola, Nicole Croatto, Veronica Lepre, Luca Cantarini, Marco Merlo, Gianfranco Sinagra, Antonio Abbate, George Lazaros, Antonio Brucato, Allan L Klein, Massimo Imazio
Aim Anakinra, an anti IL-1 agent targeting IL-1 alfa and beta, is available for the treatment of recurrent pericarditis in cases with corticosteroid dependence and colchicine resistance after failure of conventional therapies. However, it is unclear if the combination with colchicine, a non-specific inhibitor of the inflammasome targeting the same inflammatory pathway of IL-1, could provide additional
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Incidence, presentation and outcome of acute aortic dissection: results from a population-based study Open Heart Pub Date : 2024-03-01 Christian Smedberg, Rebecka Hultgren, Christian Olsson, Johnny Steuer
Objectives To describe the incidence of acute aortic dissection in a clearly defined population, to assess onset symptoms and admission biochemical marker levels and to analyse variables potentially associated to mortality. Methods Medical records and CT angiograms of all patients hospitalised for acute aortic dissection in the Stockholm County during the 5-year period 2012–2016 were reviewed. The
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Time to childbirth and assisted reproductive treatment in women with congenital heart disease Open Heart Pub Date : 2024-03-01 Sara Jonsson, Inger Sundström-Poromaa, Bengt Johansson, Jenny Alenius Dahlqvist, Christina Christersson, Mikael Dellborg, Alexandra Trzebiatowska-Krzynska, Peder Sörensson, Ulf Thilén, Anna-Karin Wikström, Annika Bay
Objective To investigate the time to first childbirth and to compare the prevalence of assisted reproductive treatment (ART) in women with congenital heart disease (CHD) compared with women without CHD. Methods All women in the national register for CHD who had a registered first childbirth in the Swedish Pregnancy Register between 2014 and 2019 were identified. These individuals (cases) were matched
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Prevalence of abnormal left ventricular global longitudinal strain by speckle tracking echocardiography and its prognostic value in patients with COVID-19 Open Heart Pub Date : 2024-03-01 Shruti Hegde, Mina Shnoda, Yasser Alkhadra, Adhiraj Bhattacharya, Maria Nikolaeva, Michael Maysky
Importance Although cardiac injury is a known complication of COVID-19 infection, there is no established tool to predict cardiac involvement and in-hospital mortality in this patient population. Objective To assess if left ventricular global longitudinal strain (LV-GLS) can detect cardiac involvement and be used as a risk-stratifying parameter for hospitalised patients with COVID-19. Main outcomes
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Validation of 2D flow MRI for helical and vortical flows Open Heart Pub Date : 2024-03-01 Zia Mehmood, Hosamadin Assadi, Ciaran Grafton-Clarke, Rui Li, Gareth Matthews, Samer Alabed, Rebekah Girling, Victoria Underwood, Bahman Kasmai, Xiaodan Zhao, Fabrizio Ricci, Liang Zhong, Nay Aung, Steffen Erhard Petersen, Andrew J Swift, Vassilios S Vassiliou, João Cavalcante, Rob J van der Geest, Pankaj Garg
Purpose The main objective of this study was to develop two-dimensional (2D) phase contrast (PC) methods to quantify the helicity and vorticity of blood flow in the aortic root. Methods This proof-of-concept study used four-dimensional (4D) flow cardiovascular MR (4D flow CMR) data of five healthy controls, five patients with heart failure with preserved ejection fraction and five patients with aortic
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Mixed plaque on coronary CT angiography predicts atherosclerotic events in asymptomatic intermediate-risk individuals Open Heart Pub Date : 2024-03-01 Josephine Warren, Andris Ellims, Jason Bloom, Nigel Sutherland, Philip Lew, Helen Kavnoudias, Sarang Paleri, Dion Stub, Andrew Taylor
Objective Coronary CT angiography (CCTA) permits both qualitative and quantitative analysis of atherosclerotic plaque and may be a suitable risk modifier in assessing patients at intermediate risk of atherosclerotic cardiovascular disease. We sought to determine the association of plaque components with long-term major adverse cardiovascular events (MACEs) in asymptomatic intermediate-risk patients
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Expanded application of wearable cardioverter defibrillators beyond current guidelines: proposal for a European register explained through single clinical scenarios Open Heart Pub Date : 2024-03-01 Veronica Buia, Francesco Ciotola, Dirk Bastian, Dorina Stangl, Janusch Walascheck, Harald Rittger, Laura Vitali-Serdoz
The wearable cardioverter defibrillator (WCD) is becoming a more and more widely used instrument for the prevention of sudden cardiac death of patients either with a secondary prevention implantable cardioverter defibrillator indication or with a transient high risk of sudden cardiac death. Although clinical practice has demonstrated a benefit of protecting patients for a period as long as 3–6 months
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Efficacy and safety of novel left ventricular pacing leads: 1-year analysis of the NAVIGATOR trial Open Heart Pub Date : 2024-02-01 Juan Gabriel Martinez, Joao De Sousa, Antoine Dompnier, Mario Martins -Oliveira, Carsten W Israel, Elvis Teijeira, José Manuel Rubin, Frederic Sebag, Maria Martino, Yann Michel, Pedro Marques
Objectives Assess safety and performance of novel quadripolar preshaped left ventricular (LV) leads: NAVIGO 4LV 2D (‘S shaped’) and NAVIGO 4LV ARC (‘U shaped’). Methods Patients indicated for cardiac resynchronisation therapy were enrolled in a multicentre, prospective, controlled study (NAVIGATOR, [NCT03279484][1]). Patients were implanted with either a NAVIGO 4LV 2D or ARC lead, and assessed at 10
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Midterm outcomes of transcatheter aortic valve replacement in patients with active cancer Open Heart Pub Date : 2024-02-01 Masahiko Noguchi, Minoru Tabata, Joji Ito, Nahoko Kato, Kotaro Obunai, Hiroyuki Watanabe, Fumiaki Yashima, Yusuke Watanabe, Toru Naganuma, Masahiro Yamawaki, Futoshi Yamanaka, Shinichi Shirai, Hiroshi Ueno, Norio Tada, Masanori Yamamoto, Kentaro Hayashida
Objectives The clinical outcomes of transcatheter aortic valve replacement (TAVR) in patients with aortic stenosis (AS) and concomitant active cancer remain insufficiently explored. This study aimed to assess the midterm outcomes of TAVR in patients diagnosed with AS and active cancer. Methods Data from the OCEAN-TAVI, a prospective Japanese registry of TAVR procedures, was analysed to compare prognoses
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Skeletal muscle mitochondrial capacity in patients with statin-associated muscle symptoms (SAMS) Open Heart Pub Date : 2024-02-01 Laura A. Mangone, Beth A. Taylor, Robert Schmelzer, Sung Gi Noh, Michael C White, Oh Sung Kwon, Paul D Thompson
Objective The objective of this article is to evaluate near-infrared spectroscopy (NIRS), a non-invasive technique to assess tissue oxygenation and mitochondrial function, as a diagnostic tool for statin-associated muscle symptoms (SAMS). Methods We verified SAMS in 39 statin-treated patients (23 women) using a double-blind, placebo-controlled, cross-over protocol. Subjects with suspected SAMS were
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Blood pressure status, trajectories and cardiovascular disease: the CoLaus|PsyCoLaus prospective study Open Heart Pub Date : 2024-02-01 Yaniv Chocron, Markos Rousakis, Peter Vollenweider, Julien Vaucher, Pedro-Manuel Marques-Vidal
Background High blood pressure (BP) is a major risk factor for cardiovascular disease (CVD). Adequate treatment of high BP should reduce the risk of CVD, but this association has seldom been assessed in a general population setting. Methods Population-based prospective study conducted in Lausanne, Switzerland, with a follow-up between 2003 and 2021. Participants were categorised as normal BP, untreated
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Personalised preinterventional risk stratification of mortality, length of stay and hospitalisation costs in transcatheter aortic valve implantation using a machine learning algorithm: a pilot trial Open Heart Pub Date : 2024-02-01 Maria Zisiopoulou, Alexander Berkowitsch, Leonard Redlich, Thomas Walther, Stephan Fichtlscherer, David M Leistner
Introduction Risk stratification based on Euroscore II (ESII) is used in some centres to assist decisions to perform transcatheter aortic valve implant (TAVI) procedures. ESII is a generic, non-TAVI-specific metric, and its performance fades for mortality at follow-up longer than 30 days. We investigated if a TAVI-specific predictive model could achieve improved predictive preinterventional accuracy
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Effect of psychosocial aspects on medication adherence in patients with heart failure amid socioeconomic challenges Open Heart Pub Date : 2024-02-01 Hiba Deek, Angela Massouh
Objective To evaluate stress, depression and quality of life among community-dwelling patients with heart failure (HF) and evaluate their effect on perceived medication adherence in a socioeconomically challenged setting. Design A cross-sectional design with self-administered questionnaire with data collected between October 2021 and September 2022. Methods Patients with confirmed diagnosis of HF were
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Prognostic value of right ventricular free-wall longitudinal strain in patients with pulmonary hypertension: systematic review and meta-analyses Open Heart Pub Date : 2024-02-01 Yosuke Nabeshima, Tetsuji Kitano, Koichi Node, Masaaki Takeuchi
Background Right ventricular (RV) dysfunction is associated with adverse outcomes in patients with pulmonary hypertension (PH). This systematic review and meta-analysis evaluated the prognostic value of RV free-wall longitudinal strain (RVfwLS), compared with other RV parameters in PH. Methods We searched for articles presenting the HR of two-dimensional RVfwLS in PH. HRs were standardised using the
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Living with myocardial ischaemia and no obstructive coronary arteries: a qualitative study Open Heart Pub Date : 2024-02-01 Helen Humphreys, Danielle Paddock, Sarah Brown, Colin Berry, Aynsley Cowie, Susan Dawkes, Simon Nichols
Objective To explore the lived experience of people with myocardial ischaemia with no obstructive arteries. Design Qualitative study using semistructured interviews. Setting Telephone interviews with 17 participants living in the UK. Participants 17 people (2 males, 15 females; aged 31–69 years) with a presumed or confirmed diagnosis of myocardial ischaemia with no obstructive arteries, recruited via
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Correction: Contemporary use and outcome of Cabrol shunt in type A aortic dissection surgery: insight from China 5A study Open Heart Pub Date : 2024-02-01 British Cardiovascular Society
Liu H, Sun B, Qian S, et al . Contemporary use and …
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Comparative evaluation of microprobe versus conventional transoesophageal echocardiography for PFO closure guidance Open Heart Pub Date : 2024-01-01 Jemina Lanki, Suvi Tuohinen, Piia Simonen, Mikko Jalanko, Juha Sinisalo
Background Patent foramen ovale (PFO) closure is traditionally guided by transoesophageal echocardiography (TEE) under general anaesthesia, which prolongs procedure duration and increases costs and risks. A transnasal echocardiography with a microTEE-probe (microTNE) is tolerated under conscious sedation and offers an effective alternative to TEE. The aim of this study was to compare the feasibility
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Patients on vitamin K treatment: is switching to direct-acting oral anticoagulation cost-effective? A target trial on a prospective cohort Open Heart Pub Date : 2024-01-01 Helena Aebersold, Fabienne Foster-Witassek, Stefanie Aeschbacher, Juerg H Beer, Eva Blozik, Manuel Blum, Leo Bonati, Giulio Conte, Michael Coslovsky, Maria Luisa De Perna, Marcello Di Valentino, Stefan Felder, Carola A Huber, Giorgio Moschovitis, Andreas Mueller, Rebecca E Paladini, Tobias Reichlin, Nicolas Rodondi, Annina Stauber, Christian Sticherling, Thomas D Szucs, David Conen, Michael Kuhne,
Aims Direct-acting oral anticoagulants (DOACs) have, to a substantial degree, replaced vitamin K antagonists (VKA) as treatments for stroke prevention in atrial fibrillation (AF) patients. However, evidence on the real-world causal effects of switching patients from VKA to DOAC is lacking. We aimed to assess the empirical incremental cost-effectiveness of switching patients to DOAC compared with maintaining
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Initiation patterns of anticoagulants for atrial fibrillation among older UK adults with and without chronic kidney disease, 2010–2020 Open Heart Pub Date : 2024-01-01 Julia Liaw, Deborah Liaw, Chintan Dave
Background There is a paucity of data on the initiation patterns of anticoagulants among older atrial fibrillation patients with and without chronic kidney disease (CKD). Setting and methods We used the UK Clinical Practice Research Datalink (2010–2020) to conduct a retrospective cohort study to evaluate anticoagulant initiation patterns for older adults (≥65 years) with CKD (N=18 421) and without
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Effect of ischaemic postconditioning on markers of myocardial injury in ST-elevation myocardial infarction: a meta-analysis Open Heart Pub Date : 2024-01-01 Idan Bergman, Shaul Gelikas, Yehuda Wexler, Omri Braver, Dennis Boyle, Udi Nussinovitch
Objectives This study aimed to perform a meta-analysis of the short-term impact of ischaemic postconditioning (IPoC) on myocardial injury in ST elevation myocardial infarction (STEMI) using surrogate cardiac biomarkers. Methods Eligible studies were identified using several article databases. Randomised controlled trials published between 1 January 2000 and 1 December 2021 comparing IPoC to standard
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Outpatient care of adults with congenital heart disease in the UK: a qualitative appraisal of the clinician perspective Open Heart Pub Date : 2024-01-01 Isobel Chaudhry, Anisa Ghassani, Jo Wray, Bill Chaudhry, Louise Coats
Objective This study aimed to explore clinicians’ perspectives of ambulatory care in adult congenital heart disease (ACHD). Methods Semistructured interviews were carried out remotely (Zoom) with a range of physicians providing ambulatory care to patients with ACHD across the UK. The chronic care model, thrive and candidacy frameworks were used to design prompt guides and subsequently develop themes
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Implementing a comprehensive STEMI protocol to improve care metrics and outcomes in patients with in-hospital STEMI: an observational cohort study Open Heart Pub Date : 2024-01-01 Christopher N Kanaan, Nicholas Kassis, Raunak M Nair, Anirudh Kumar, Chetan P Huded, Kathleen Kravitz, Grant W Reed, Amar Krishnaswamy, A Michael Lincoff, Jaikirshan Khatri, Rishi Puri, Khaled Ziada, Ravi Nair, Samir Kapadia, Umesh Khot
Background Patients who experience in-hospital ST-segment elevation myocardial infarction (iSTEMI) represent a uniquely high-risk cohort owing to delays in diagnosis, prolonged time to reperfusion and increased mortality. Quality initiatives aimed at improving the care of this vulnerable, yet understudied population are needed. Methods This study included consecutive patients with iSTEMI treated with
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Thromboembolic and bleeding events after valvular intervention in patients with atrial fibrillation Open Heart Pub Date : 2024-01-01 Ebba-Louise Skogseid, Gorav Batra, Johan Westerbergh, Claes Held, Christina Christersson
Aim To assess outcomes after cardiac surgery with biological valve replacement, valve repair or transcatheter aortic valve implantation (TAVI) in patients with atrial fibrillation (AF) in accordance with oral anticoagulant (OAC) treatment. Methods All patients in Sweden undergoing valvular intervention with AF were included. Associations between OAC exposure and cardiovascular (CV) events (composite
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Cost-effectiveness of stepwise provisional versus systematic dual stenting strategies in patients with distal bifurcation left main stem lesions: economic analysis of the EBC MAIN trial Open Heart Pub Date : 2024-01-01 Alicia Le Bras, David Hildick-Smith, Arnaud Nze Ossima, Olivier Supplisson, Mohaned Egred, Philippe Brunel, Adrian P Banning, Marie-Claude Morice, Isabelle Durand-Zaleski
Background In patients with distal bifurcation left main stem lesions requiring intervention, the European Bifurcation Club Left Main Coronary Stent Study trial found a non-significant difference in major adverse cardiac events (MACEs, composite of all-cause death, non-fatal myocardial infarction and target lesion revascularisation) favouring the stepwise provisional strategy, compared with the systematic
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Multiprofessional heart failure self-development framework Open Heart Pub Date : 2024-01-01 Paul Forsyth, Susan Young, Kirsty Hughes, Ruby James, Cheryl Oxley, Ruth Kelly, Rebecca Jones, Sarah Briggs, Lynn Mackay-Thomas, Yvonne Millerick, Maggie Simpson, Clare J Taylor, Simon Beggs, Susan Piper, Simon Duckett
Objective Heart failure remains a key public health priority across the globe. The median age of people with heart failure admitted to hospital in the UK is 81 years old. Many such patients transcend the standard interventions that are well characterised and evidenced in guidelines, into holistic aspects surrounding frailty, rehabilitation and social care. Previous published competency frameworks in
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Reflections on my journey as editor-in-chief of Open Heart Open Heart Pub Date : 2024-01-01 Pascal Meier
As I approach the end of my tenure as founding editor-in-chief of Open Heart , I am filled with a sense reflection on this very exciting journey. When we launched Open Heart in January 2014, our mission was to advance scientific publishing in cardiovascular sciences by embracing open science, making research results available to everyone. This was a response to the limitations of traditional publishing
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Association of HFA-PEFF score with clinical outcomes after catheter ablation for atrial fibrillation Open Heart Pub Date : 2024-01-01 Taiji Okada, Takeshi Kitai, Atsushi Kobori, Madoka Sano, Ryosuke Murai, Toshiaki Toyota, Yasuhiro Sasaki, Tomohiko Taniguchi, Kitae Kim, Natsuhiko Ehara, Makoto Kinoshita, Yutaka Furukawa
Background The Heart Failure Association Pretest assessment, echocardiography and natriuretic peptide, functional testing and final aetiology (HFA-PEFF) score has been developed for diagnosing heart failure with preserved ejection fraction (HFpEF), which is frequently associated with atrial fibrillation (AF). We aimed to investigate whether preprocedural HFA-PEFF score could be used to predict clinical
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Prognostic value of right ventricular dyssynchrony in adults with repaired tetralogy of Fallot Open Heart Pub Date : 2024-01-01 Andrea Papa, Clement Nussbaumer, Eleni Goulouti, Fabienne Schwitz, Kerstin Wustmann, Daniel Tobler, Matthias Greutmann, Markus Schwerzmann
Objective Residual sequelae after surgical repair of tetralogy of Fallot (rTOF) affect clinical outcome. We investigated the prognostic impact of right ventricular (RV) dyssynchrony in adults with rTOF years after the surgical repair. Methods Patients from the Swiss Adult Congenital HEart disease Registry were included. NT-proBNP levels, echocardiography, exercise testing and MRI data were collected
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Use of sacubitril/valsartan early after CABG Open Heart Pub Date : 2024-01-01 Madina Nurzhanova, Aisulu Musagaliyeva, Raushan Zhakypova, Daniya Senkibayeva, Amina Rakisheva
Background Heart failure (HF) remains a major public health problem with a high mortality and morbidity worldwide. Currently, there is no optimal revascularisation strategy for patients with ischaemic cardiomyopathy despite suggestions that coronary artery bypass graft (CABG) may be superior to medical therapy in improving survival. However, CABG may be associated with substantial risk in HF subjects
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Economic evaluation of first-line cryoballoon ablation versus antiarrhythmic drug therapy for the treatment of paroxysmal atrial fibrillation from an English National Health Service perspective Open Heart Pub Date : 2024-01-01 John Paisey, Joe Moss, Jason Andrade, Malte Kuniss, Oussama Wazni, Gian Battista Chierchia, Stuart Mealing, Eleni Ismyrloglou, Alicia Sale, Maxim Souter, Rachelle Kaplon, Tom Bromilow, Emily Lane, Damian Lewis, Derick Todd
Introduction Three recent randomised controlled trials have demonstrated that pulmonary vein isolation as an initial rhythm control strategy with cryoablation reduces atrial arrhythmia recurrence in patients with symptomatic paroxysmal atrial fibrillation (PAF) compared with antiarrhythmic drug (AAD) therapy. The aim of this study was to evaluate the cost-effectiveness of first-line cryoablation compared
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Accelerating progress in cardiology: embracing open science Open Heart Pub Date : 2024-01-01 Pascal Meier
Open science is not only compelling but also essential for the advancement of cardiology. Open science encompasses open-access publishing, data sharing and open source. It embodies a set of practices aiming for greater transparency and collaboration in research (figure 1). It is pivotal for driving innovation, ensuring research integrity and democratising access to scientific knowledge. The societal
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Colchicine in acute myocardial infarction: cardiovascular events at 1-year follow up Open Heart Pub Date : 2024-01-01 Claire Bouleti, Simon Viscogliosi, Didier Bresson, Simon Leboube, Thomas Bochaton, Naoual El-Jonhy, Camille AMAZ, Fabrice Prunier, Gabriel Bidaux, Francois Roubille, Denis Angoulvant, Nathan Mewton
Objective In the COVERT-MI randomised placebo-controlled trial, oral administration of high-dose colchicine at the time of reperfusion and for 5 days in acute ST-elevated myocardial infarction did not reduce infarct size but was associated with a significant increase in left ventricular thrombus (LVT) in comparison to placebo. We aimed to assess the 1-year clinical outcomes of the study population
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Cardiology researchers’ practices and perceived barriers to open science: an international survey Open Heart Pub Date : 2024-01-01 Kelly D Cobey, Mohsen Alayche, Sara Saba, Nana Yaa Barnes, Sanam Ebrahimzadeh, Emilio Alarcón, Benjamin Hibbert, David Moher
Objective Open science is a movement and set of practices to conduct research more transparently. Implementing open science will significantly improve public access and supports equity. It also has the potential to foster innovation and reduce duplication through data and materials sharing. Here, we survey an international group of researchers publishing in cardiovascular journals regarding their perceptions
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Correction: Multimorbidity of cardiovascular disease subtypes in a prospective cohort of 1.2 million UK women Open Heart Pub Date : 2024-01-01 British Cardiovascular Society
Suh JW, Floud S, Reeves GK, et al . Multimorbidity of cardiovascular disease subtypes in a prospective cohort of 1.2 million …
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Fluoroquinolones do not provide added risk of out-of-hospital cardiac arrest: a nationwide study Open Heart Pub Date : 2024-01-01 Viktoría Ellenardóttir, Ruben Coronel, Fredrik Folke, Andrim Halili, Anojhaan Arulmurugananthavadivel, Saaima Parveen, Mikkel Porsborg Andersen, Morten Schou, Christian Torp-Pedersen, Gunnar Gislason, Talip E Eroglu
Aim Conflicting results have been reported regarding the association between fluoroquinolones (FQs) and the risk of out-of-hospital cardiac arrest (OHCA). In particular, it has not become clear whether OHCA in FQ users is related to the inherent comorbidities or whether there is a direct pro-arrhythmic effect of FQs. Therefore, we studied the relation between FQs and OHCA in the general population
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Nitroglycerin use and adverse clinical outcomes in elderly patients with acute coronary syndrome Open Heart Pub Date : 2024-01-01 Soichi Komaki, Yunosuke Matsuura, Hiroki Tanaka, Kohei Moribayashi, Yoshimasa Yamamura, Kazumasa Kurogi, Takeshi Ideguchi, Nobuyasu Yamamoto, Michikazu Nakai, Toshihiro Tsuruda, Koichi Kaikita
Objective The primary care for acute coronary syndrome (ACS) includes the administration of nitroglycerin (GTN). This study aimed to investigate the association between the use of GTN before percutaneous coronary intervention (PCI) for ACS and clinical outcomes. Methods Nine-hundred and forty-seven patients who underwent PCI for ACS were examined and classified into two groups: those who were treated
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Systematic review and meta-analysis of early aortic valve replacement versus conservative therapy in patients with asymptomatic aortic valve stenosis with preserved left ventricle systolic function Open Heart Pub Date : 2024-01-01 Nagendra Boopathy Senguttuvan, Nishok Victory Srinivasan, Manokar Panchanatham, Rizwan Suliankatchi Abdulkader, Asuwin Anandaram, Dinesh Reddy Polareddy, Sankaran Ramesh, Harsimran Singh, Hanumath Yallanki, Dhamodaran Kaliyamoorthi, Sundar Chidambaram, Vadivelu Ramalingam, Ravindran Rajendran, Thoddi Ramamurthy Muralidharan, Ravindar Rao, Ashok Seth, Bimmer Claessen, Parasuram Krishnamoorthy
Background A quarter of patients with severe aortic stenosis (AS) were asymptomatic, and only a third of them survived at the end of 4 years. Only a select subset of these patients was recommended for aortic valve replacement (AVR) by the current American College of Cardiology/American Heart Association guidelines. We intended to study the effect of early AVR (eAVR) in this subset of asymptomatic patients
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Impact of serum haemoglobin-to-creatinine ratio after transcatheter aortic valve implantation Open Heart Pub Date : 2023-12-01 Akihiro Ikuta, Satoki Oka, Shunsuke Matsushita, Shingo Hirao, Kazushige Kadota, Tatsuhiko Komiya, Yasushi Fuku
Objective The association between a combined anaemia and renal failure index and 1-year prognosis of patients undergoing transcatheter aortic valve implantation (TAVI) is unexplored. We aimed to investigate a simple risk score in patients undergoing TAVI. Methods A total of 469 consecutive patients undergoing TAVI between 2015 and 2021 were enrolled. After excluding patients undergoing dialysis, the
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Differences in treatment and clinical outcomes in patients aged ≥75 years compared with those aged ≤74 years following acute coronary syndromes: a prospective multicentre study Open Heart Pub Date : 2023-12-01 Michael Lawless, Abdulla Damluji, Valerie Josephine Dirjayanto, Gregory Mills, Graziella Pompei, Francesca Rubino, Vijay Kunadian
Objective This study describes the differences in treatment and clinical outcomes in patients aged ≥75 years compared with those aged ≤74 years presenting with acute coronary syndrome (ACS) and undergoing invasive management. Methods A large-scale cohort study of patients with ST-elevation/non-ST-elevation myocardial infarction (MI)/unstable angina underwent coronary angiography (January 2015–December
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Implementation of the European Society of Cardiology 0/3-hour accelerated diagnostic protocol, using high sensitive troponin T: a clinical practice evaluation of safety and effectiveness involving 3003 patients with suspected acute coronary syndrome Open Heart Pub Date : 2023-12-01 James Daniel Hatherley, Thomas Salmon, Paul O Collinson, Aleem Khand
Background There have been relatively few studies detailing the real-world effectiveness and safety of accelerated diagnostic protocols (ADP), using high sensitivity cardiac troponin (hs-cTn). Objective To analyse the safety and effectiveness of early emergency department (ED) discharge following implementation of the European Society of Cardiology (ESC) 0/3-hour ADP for suspected acute coronary syndromes
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Women have less progression of paroxysmal atrial fibrillation: data from the RACE V study Open Heart Pub Date : 2023-12-01 Bart A Mulder, Neda Khalilian Ekrami, Martijn E Van De Lande, Bao-Oanh Nguyen, Vanessa Weberndorfer, Harry J Crijns, Bastiaan Geelhoed, Yuri Blaauw, Martin EW Hemels, Robert G Tieleman, Coert OS Scheerder, Mirko De Melis, Ulrich Schotten, Dominik Linz, Isabelle C Van Gelder, Michiel Rienstra
Background Sex differences in atrial fibrillation (AF) are observed in terms of comorbidities, symptoms, therapies received, AF progression and cardiovascular complications. Methods We assessed the differences in prevalence and the determinants of AF progression, as well as the clinical characteristics and quality of life (QoL), between women and men with paroxysmal AF included in the RACE V (Reappraisal
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Cardiac MR modelling of systolic and diastolic blood pressure Open Heart Pub Date : 2023-12-01 Hosamadin Assadi, Gareth Matthews, Xiaodan Zhao, Rui Li, Samer Alabed, Ciaran Grafton-Clarke, Zia Mehmood, Bahman Kasmai, Vaishali Limbachia, Rebecca Gosling, Gurung-Koney Yashoda, Ian Halliday, Peter Swoboda, David Paul Ripley, Liang Zhong, Vassilios S Vassiliou, Andrew J Swift, Rob J van der Geest, Pankaj Garg
Aims Blood pressure (BP) is a crucial factor in cardiovascular health and can affect cardiac imaging assessments. However, standard outpatient cardiovascular MR (CMR) imaging procedures do not typically include BP measurements prior to image acquisition. This study proposes that brachial systolic BP (SBP) and diastolic BP (DBP) can be modelled using patient characteristics and CMR data. Methods In
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Heart failure: it’s time to finally change the F-word Open Heart Pub Date : 2023-12-01 Carolyn Thomas
One of the organisers of an upcoming medical conference on heart failure told me that the theme of this meeting ‘was intended to provide hope’. Noble intention, indeed. Yet that’s the problem with the name heart ‘failure’. By definition, it s tough to ‘provide hope’ while continuing to tell freshly diagnosed heart patients that their hearts are ‘failing’. I often hear from my readers who have sat through